@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_01_0770: (2018-03-07 )
MSLPSMSLHWSEGDNGGGSLGGSRRSFSKGSIYRHHFLSLDHSSARDVAVGLSRDVTNDRRATGTSAGFEWLQPWRTPQDCREGGVALLYSMQEVLENVRRARKTSLSELYAARGAGSPAASTTSLCHPQHLCPPRAATSGSSDDAEGRCGSVGEKSSCSAAGSRTSSVDRRRQRDRGERNVSVGKGVRSASDDSVQGIELATEVGRVAFSPPLQTATAAAASVPPIVPVIPRFSEVKTEQELIHQRQQQQPQPHPRSEAAKRRRCALANSGDDDDDAARSPHHPDASCPSGGCDQTARPGDSRHRPGMSVEWSGSDSNGDEPEALAQRRHASGVSADDDDVDTSNVHHGKDEERDEEEDRLSETDFGEGGHLACVPGDTLHQRYTLLKALGVGRSSRVWLAVDLEQCSLARCQLIRELGEREVRRLFRTLERPMFVAIKVFRCDPAYADCATYELKLSALIHENVMRRRQQQQQQQQRWPPARASHSASLPSSPIAVPAACDDPGGDLQESSDGGENSTSRPCDEAAVRTRADPTSSTPRSGRISNSGSVSAEVASPASTSATAFSGRLTTVRDAFAVEGAFGTHQCLVMDVLGAGVDRAINEAHLNGFPSAVARSIMQSSLQGLVLLAACHLVHTDIKPENLFFTDLEDDVAEEMLTFQSAQLHASQRQTLCSSFAHRSTAASVMMEREEVAAHEQQQQQHHGDGGTAEHTGVGQRSPFSDPSLPDYTHVDEAAADLHTVHAANAADAGASGDRVASSVTTLSAVAGGHDTLHSSQDSIAQVSRRPNFARTPTRRRSAYDVRLSGLGLSLVVPPCLRLGVRVLANYAADGGGMTADELVRQDPLEQLHWLCAQQQARLLRLPGDDDDDGLGSVAEPWREERWRLAGACAPAESPPPPTLDIGMSEDFIDEAELRALGLQELPKSDADGGRCAAGMAPDEYEEADVTDFVGVPAVDKPAAHHRTTVTTADVGVVGGTLPPATWRTASAATRAGGGRRTPLAAAKRRLFAQCFHEGLATPRDPATVLTRCEGVAAASPTDSSSNSSSGAAPPAGAAAAAAAAATVLRRLECEIVRHQNYRRGAVLQSREYRAPEVLLGDFVLPACDIWSMGCIAYELVSGRFLIDCIVDRERFATALSWQQQQRHGRKGCRAPDDDGGGAHDAKDHSRDDDEDTQQRLNKWDGRPVYLEDTEQDLDVFHLKAIMRLLGPPPVSFLRQQPIGLFIDDFFDEHGNFRFWERGEAQEAGMRLADPYRQLELTHWAAASRVSGASVAVGSGADRQQSPPLPESVSGVAASLDTDPPGAPSAASVGQHVASAQARRDPQDTMNYPIRTPAWQDVQAILREKLGSAEEAADFEVFLRRCLQWDPARRATAAELLADKWLVKYSGVVADASESDVVAEKEGGGDSDGEERRL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.-.-......390.......400...-....410.....-------..420.......430.........440.....------.-------.450.......460..--.....470.......480.......490.......500.......510.......520......----.530.......-540-.........550.......560.......570......-------------.580-.--......590..-...-..600.-....--..610.......620....-...630-.......640.....------..650.......660.......670.......680.......690.-......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810..--.....820..-----.....830.......840.......850.......860.......870.....--..880.....--..890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000.....------.1010------.......1020......1030-----.......1040......1050......1060------......1070..-----....1080..--------------------....1090......1100......1110......1120------.........1130....--------..1140......1150--.....---...1160....--..1170----........1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSLP
S
M
S
L
H
WSEGDNGGGSLGGSRRSFSKGS
I
Y
R
H
H
F
L
SLDHSSAR
D
V
A
VGLSRDVTNDRRATGTSA
G
F
E
W
L
QPWR
T
P
Q
D
C
R
EG
G
V
A
L
L
Y
S
M
Q
E
V
L
E
N
V
R
R
A
R
K
T
S
L
S
E
L
Y
A
ARGAGSPAASTTSLCHPQHLCPPRAATSGSSDDAEGRCGSVGEKSSCSAAGSRT
S
S
V
D
R
R
R
Q
RDRGERNVSVGKGVRSASDDSVQ
G
I
E
L
A
T
EVG
R
V
AFSPPLQTATAAAASVPPIVPVIP
R
F
S
EVK
T
E
Q
E
L
I
H
Q
R
Q
QQQPQPH
P
R
S
E
A
A
K
R
R
R
CALANSGDDDDDAARSPHHPDASCPSGGCDQTARPGDSRHRPG
M
S
V
E
WSGSDSNGD
E
P
E
A
L
A
Q
R
RHASGVSADDDDVDTSNVHHGKDEER
D
E
E
E
DRLSETDFGEGG
H
L
A
CVPG
D
T
L
-
H
-
Q
-
R
Y
T
L
L
K
A
LGVGRS
S
R
V
W
L
A
V
D
L
-
E
Q
C
S
L
A
R
C
Q
L
I
R
-------
E
L
G
E
R
E
V
R
R
L
F
R
T
--LER
P
M
F
V
A
I
K
V
F
RCDPA------Y-------AD
C
A
T
Y
E
L
K
L
S
A
L
I
H
E
--
N
V
M
R
R
R
Q
Q
Q
Q
Q
Q
Q
QRWPPARASHSASLPSSPIAVPAACDDPGGDLQESSDGGENSTSRP
C
D
E
A
A
----VRTRADPTSST-P---RSGRISNSGS
V
S
A
E
VASPASTSATAFSGRL
T
T
V
R
D
A
F
A
-------------VEGA-F--GT
H
Q
C
L
V
M
D
V
L
-
G
A
G
-
V
D
R
A
I
N
-
E
A
HL--NG
F
P
S
A
V
A
R
S
I
M
Q
S
S
L
Q
G
L
-
V
L
L
A
A
C
-
H
L
V
HTDIKPEN
L
F
F
T------DL
E
D
D
V
A
E
E
M
L
T
F
Q
S
A
Q
L
H
A
S
Q
R
Q
T
L
C
S
S
F
AH
R
S
T
A
A
S
V
M
M
E
R
E
E
V
-
A
A
H
E
Q
Q
Q
Q
Q
HHGDGGTAEHTGVGQRSPFSDPSLPD
Y
T
H
V
D
E
A
A
A
D
L
H
T
V
HAANAADAGASG
D
R
V
A
S
S
V
T
T
L
S
A
VAGGHDTLHSS
Q
D
S
I
A
Q
V
SRRPNFARTPTRRR
S
A
Y
D
V
R
LSGL
G
L
S
LV
V
--
P
P
C
L
R
L
G
V
R
V
-----
L
A
N
YAADGGGM
T
A
D
E
L
V
R
Q
D
P
L
E
Q
L
H
W
L
C
A
Q
Q
Q
A
R
LLRLPGDDDDDG
L
G
S
V
A
E
--
P
W
R
E
E
R
W
RLA--GACAPAESPPPP
T
L
DIGMSEDFI
D
E
A
E
L
R
A
L
G
L
Q
ELPKSDADGGRCAAGMAPDEYEEADVTDFVGVPAVDKPAAHH
R
T
T
V
T
T
A
D
V
GVVGGTLPPATWRTASAATRAGGGRRT
P
L
A
A
A
K
R
R
L
------
F
A
Q
C
-------
F
H
EGLATPR
D
P
A
T
V
L
T
RCEG------VAAASPTDSSSNSSSGAAPPA
G
A
A
A
A
A
A
A
A
A
------
T
V
L
R
R
L
E
C
E
I
V
R-----HQNYRRGAVL--------------------QSREYRAP
E
V
L
LGDFVLP
A
C
D
I
W
S
M
G
C
I
A
Y
E
LVSG---------
R
F
L
I
D
CIV
D
R
E
R
F
A
T
A
L
--------
S
W
Q
Q
Q
Q
R
HGRKGCR----APDDD---GGGAHDAKDHS--RDD
D
------
E
D
T
Q
Q
R
L
N
KWDG
R
P
V
Y
LEDTEQ
D
L
D
V
F
H
L
K
A
I
M
R
LLGPP
P
V
S
F
L
RQQP
I
G
L
F
I
D
D
F
F
DEHG
N
F
R
F
W
ERG
E
A
Q
EAGMRLA
D
P
Y
R
Q
L
E
L
T
H
W
AAASRVSG
A
S
V
AVGSGADRQQSPPL
P
E
S
V
S
G
V
A
ASLDTDPPGAP
S
A
A
S
V
G
Q
H
V
A
S
A
Q
ARRDP
Q
D
TMNYPIRTP
A
W
Q
D
V
Q
A
I
L
R
E
KLGS
A
E
EA
A
D
F
E
V
F
L
R
R
C
LQWDPAR
R
A
T
A
A
E
L
L
A
D
K
W
L
V
K
YS
G
V
VADASES
D
V
V
A
EKEGGGDSDGEERRL
21
HHSearch
65.14
33%
0
- C- -
-
5MY8
11
?
A:
[9-190]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
G
Y
H
L
V
K
I
G
D
L
F
-
N
-
G
-
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
I
-
Q
G
K
-----------------------------------
K
F
V
A
M
K
V
V
K
S
A
E
H
------
Y
-------
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
N
--
S
D
P
-------------------------------------------------------------------------------------------------------
N
D
P
N
R
E
M
V
V
Q
L
L
D
D
F
K
-------------
I
S
G
V
-
N
--
G
T
H
I
C
M
V
F
E
V
L
-
G
H
H
L
L
K
W
I
I
K
-
S
-
N
Y
--
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
-
D
Y
L
H
T
K
C
R
I
I
H
T
D
I
K
P
E
N
I
L
L
S
------
V
N
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
63.99
24%
-130
- C2 -
-
4AZF
1
DYRK2_HUMAN
A:
[91-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
H
D
H
V
-
A
-
Y
-
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
-----------------------------------
Q
H
V
A
L
K
M
V
R
N
E
K
R
------
F
-------
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
--
Q
---------------------------------------------------------------------------------------------------------
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
-------------
F
R
-------
N
H
I
C
M
T
F
E
L
L
-
S
M
N
-
L
Y
E
L
I
K
-
K
N
K
F
--
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
-
D
A
L
H
K
N
-
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
------
Q
Q
G
R
-
S
G
I
K
V
I
D
F
G
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
63.39
25%
-136
- C2 -
-
5LXC
6
DYRK2_HUMAN
A:
[67-216]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
V
P
H
D
H
V
-
A
-
Y
-
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
-----------------------------------
Q
H
V
A
L
K
M
V
R
N
E
K
R
------
F
-------
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
--
Q
---------------------------------------------------------------------------------------------------------
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
-------------
F
R
-------
N
H
I
C
M
T
F
E
L
L
-
S
M
N
-
L
Y
E
L
I
K
-
K
N
K
F
--
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
-
D
A
L
H
K
N
-
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
------
Q
Q
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
61.59
30%
-60
- C2 -
-
1Q8Y
1
?
B:
[9-168]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
F
K
G
E
P
Y
-
K
D
A
-
R
Y
I
L
V
R
K
L
G
---
F
S
T
V
W
L
A
K
D
M
-
V
N
N
-----------------------------------
T
H
V
A
M
K
I
V
R
G
D
K
V
------
Y
-------
T
E
A
A
E
D
E
I
K
L
L
Q
R
V
N
D
--
A
D
N
----------------------------------------------------------------------------------------------------
T
K
E
D
S
M
G
A
N
H
I
L
K
L
L
D
H
F
N
-------------
H
K
G
P
-
N
--
G
V
H
V
V
M
V
F
E
V
L
-
G
E
N
-
L
L
A
L
I
K
-
K
Y
E
H
--
R
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
-
D
Y
M
H
R
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
M
E
------
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
61.37
30%
-62
- C2 -
-
1Q99
2
SKY1_YEAST
B:
[5-168]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
Y
H
P
A
F
K
G
E
P
Y
-
K
D
A
-
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
M
-
V
N
N
-----------------------------------
T
H
V
A
M
K
I
V
R
G
D
K
V
------
Y
-------
T
E
A
A
E
D
E
I
K
L
L
Q
R
V
N
D
--
A
D
N
----------------------------------------------------------------------------------------------------
T
K
E
D
S
M
G
A
N
H
I
L
K
L
L
D
H
F
N
-------------
H
K
G
P
-
N
--
G
V
H
V
V
M
V
F
E
V
L
-
G
E
N
-
L
L
A
L
I
K
-
K
Y
E
H
--
R
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
-
D
Y
M
H
R
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
M
E
------
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
55.21
13%
18
- C2 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
----
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
---
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
R
A
E
E
L
M
A
CAGLTSPR
I
V
P
L
Y
G
A
-
V
R
E
G
P
W
V
N
I
F
M
E
L
L
-
E
G
G
-
S
L
G
Q
L
V
-
K
E
Q
---
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
-
E
Y
L
H
S
R
-
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
SDGS
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
I
P
G
T
E
T
H
M
A
P
E
V
V
L
G
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
-
L
N
G
C
H
P
W
T
Q
F
F
R
G
P
L
C
L
K
I
A
S
----
E
P
P
P
V
R
E
I
P
P
--
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
53.84
23%
-45
- C2 -
-
4IJP
1
B:
[13-186]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
-
D
-
K
-
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
N
A
R
A
N
-----------------------------------
Q
E
V
A
V
K
I
I
R
N
N
E
L
------
M
-------
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
--
A
D
---------------------------------------------------------------------------------------------------------
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
-------------
H
K
-------
Q
H
L
C
L
V
F
E
P
L
-
S
M
N
-
L
R
E
V
L
K
-
K
Y
G
K
D-
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
-
K
L
L
K
R
C
-
N
I
L
H
A
D
I
K
P
D
N
I
L
V
N
------
E
S
K
T
--
I
L
K
L
C
D
F
G
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
53.68
23%
-47
- C2 -
-
4IIR
1
PRP4B_HUMAN
A:
[13-192]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
-
D
-
K
-
R
Y
N
V
Y
G
Y
T
G
Q
G
--
S
N
V
V
R
A
R
D
N
A
R
A
N
-----------------------------------
Q
E
V
A
V
K
I
I
R
N
N
E
L
------
M
-------
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
--
A
D
---------------------------------------------------------------------------------------------------------
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
-------------
H
K
-------
Q
H
L
C
L
V
F
E
P
L
-
S
M
N
-
L
R
E
V
L
K
-
K
Y
G
K
D-
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
-
K
L
L
K
R
C
-
N
I
L
H
A
D
I
K
P
D
N
I
L
V
N
------
E
S
K
T
--
I
L
K
L
C
D
F
G
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
50.72
20%
30
- C2 -
-
5KCV
1
AKT1_HUMAN
A:
[20-452]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
E
G
W
L
H
K
R
G
E
YI
T
W
R
P
R
Y
F
L
L
K
ND
G
T
F
I
G
Y
K
E
R
P
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
--------
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
-----
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
R
V
T
M
N
E
F
E
Y
L
K
-
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
V
L
Q
N
S
RHP
F
L
T
A
-------
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
------
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
SEKN
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
KDG
H
I
K
I
T
D
F
G
L
C
--------------------
P
--
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
---------
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
MEEIRFPR
T
L
G
P
E
A
K
S
L
L
S
G
L
L
----
K
K
D
P
K
QRL
G
G
G
S
E
D
A
K
E
I
M
--
Q
H
R
F
FAGIV
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
48.46
18%
-41
- C2 -
-
4B4L
3
DAPK1_HUMAN
A:
[7-152]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
E
N
V
-
D
-
D
-
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
-
S
T
G
-----------------------------------
L
Q
Y
A
A
K
F
I
K
K
R
R
T
------
K
SSRRGVS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-----------------------------------------------------------------------------------------------------------------
Q
H
P
N
V
I
T
L
H
E
V
Y
E
-------------
N
K
-------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
-
L
F
D
F
L
A
-
E
K
----
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
-
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
------
D
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
48.28
20%
-65
- C2 -
-
3C0I
1
CSKP_HUMAN
A:
[20-179]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
F
E
-
D
-
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
-
E
T
G
-----------------------------------
Q
Q
F
A
V
K
I
V
D
V
A
K
F
------
T
S
SPGLS-
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-----------------------------------------------------------------------------------------------------------------
K
H
P
H
I
V
E
L
L
E
T
Y
S
-------------
S
D
-------
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
-
L
C
F
E
I
V
-
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
-
R
Y
C
H
D
N
-
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
------
S
K
E
N
S
A
P
V
K
L
G
G
F
G
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
47.05
16%
-115
* C2 *
-
1TKI
-
TITIN_HUMAN
A:
[19-168]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
-
Y
-
E
-
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
-
S
S
K
-----------------------------------
K
T
Y
M
A
K
F
V
K
V
K
G
T
------
D
-------
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-----------------------------------------------------------------------------------------------------------------
R
H
R
N
I
L
H
L
H
E
S
F
E
-------------
S
M
-------
E
E
L
V
M
I
F
E
F
I
S
G
L
D
-
I
F
E
R
I
N
-
T
S
-
A
--
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
-
Q
F
L
H
S
H
-
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
------
T
R
R
-
S
S
T
I
K
I
I
E
F
G
Q
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
46.67
20%
-57
- C2 -
-
3C0G
1
CSKP_HUMAN
B:
[19-179]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
-
D
-
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
-
E
T
G
-----------------------------------
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SPGL
S
-------
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-----------------------------------------------------------------------------------------------------------------
K
H
P
H
I
V
E
L
L
E
T
Y
S
-------------
S
D
-------
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
-
L
C
F
E
I
V
-
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
-
R
Y
C
H
D
N
-
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
------
S
K
E
N
S
A
P
V
K
L
G
G
F
G
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
43.63
12%
35
- C2 -
-
4EUT
1
TBK1_HUMAN
A:
[2-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
-
F
---
A
I
K
V
F
N
N
I
S
F
L
R
P
V
D
V
Q
M
R
E
F
E
V
L
K
K
L
N
H
K
N
I
V
K
L
F
A
I
-------------
E
E
E
T
-
T
--
T
R
H
K
V
L
I
M
E
F
C
-
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
--
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
-
N
H
L
R
E
N
-
G
I
V
H
R
N
I
K
P
G
N
I
M
R
V
------
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
E
Q
F
V
S
L
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
D
H
Q
K
K
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
SYNT
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
--
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
42.95
14%
15
- C2 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
T
D
Q
V
L
V
K
K
E
I
S
I
------
L
N
I
A
RHRNILH
L
H
E
S
F
E
S
M
E
E
L
V
M
I
F
E
F
I
S
G
LD
I
F
E
R
I
N
T
S
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
------
I
G
H
F
D
I
R
P
E
N
I
I
-----
Y
Q
T
R
R
S
S
T
I
K
IIEFGQARQLKPG
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
INPFLAET
N
Q
Q
I
I
E
N
I
M
N
A
E
Y
T
F
D
E
E
--------
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
LV
K
E
R
K
S
---
R
M
T
A
S
E
A
L
Q
H
P
WL
K
Q
K
I
------
E
R
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
-
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
38.96
40%
-133
- C2 -
-
5MYV
2
SRPK2_HUMAN
A:
[102-191]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
F
K
-------------
I
S
G
M
-
N
--
G
I
H
V
C
M
V
F
E
V
L
-
G
H
H
-
L
L
K
W
I
I
-
K
S
N
Y
--
Q
G
L
P
V
R
C
V
K
S
I
I
R
Q
V
L
Q
G
L
D
Y
L
H
S
K
C
-
K
I
I
H
T
D
I
K
P
E
N
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
37.25
12%
8
- C2 -
-
3UQC
-
MVINL_MYCTU
A:
[20-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
V
P
G
A
R
I
-
A
-
N
G
R
Y
R
L
L
I
F
H
G
G
V
P
P
L
Q
F
W
Q
A
L
D
T
-
A
L
D
R
Q
V
A
L
T
F
V
D
PQGVLP
D
D
V
L
Q
E
T
L
S
R
T
L
R
L
S
R
I
D
K
P
G
V
A
R
V
L
D
V
V
H
T
R
A
------
G
-------
G
L
V
V
A
E
W
I
R
G
G
S
L
Q
E
V
A
D
T
S
P
S
P
V
G
A
I
R
A
M
Q
S
L
A
A
A
A
D
A
A
H
R
A
G
V
A
L
S
I
D
H
P
S
R
V
R
V
S
I
D
G
D
V
V
L
A
Y
P
A
T
M
P
D
A
N
P
Q
D
D
I
R
G
----
I
G
A
S
L
Y
A
L
L
V
N
-
R
WPL
P
E
A
G
V
R
S
G
L
A
P
A
E
R
D
T
A
G
Q
P
I
E
P
A
D
I
D
R
D
I
P
F
Q
I
S
A
V
A
-------------
A
R
S
V
-
Q
--
G
D
G
G
I
R
S
A
S
T
L
-
L
N
L
-
M
Q
Q
A
T
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
36.14
13%
-58
- C2 -
-
3RP9
-
?
A:
[111-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
H
V
V
K
V
L
D
I
V
I
-------------
P
K
D
V
E
K
--
F
D
E
L
Y
V
V
L
E
I
A
-
D
S
D
-
F
K
K
L
F
R
-
T
P
----
V
Y
L
T
E
L
H
I
K
T
L
L
Y
N
L
L
V
G
V
-
K
Y
V
H
S
A
-
G
I
L
H
R
D
L
K
P
A
N
C
L
V
N
------
Q
D
C
---
S
V
K
V
C
D
F
G
L
A
R
T
V
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
35.04
48%
-146
* C3 *
-
4IJP
-
PRP4B_HUMAN
A:
[195-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------------------
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
---------
K
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
34.92
48%
-154
- C3 -
-
4IIR
-
PRP4B_HUMAN
A:
[195-243]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------------------
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
---------
K
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------