@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_02_0260: (2018-03-07 )
MEERFDWMTFGDDVSGAQAGSAAPPSTGADEDVPIFLREDVGMVRAGASHATAASESTGVDSENGAPAFLAVCPGADVAPRLSGGWSSEGSPVWDGSLRQQQKPSSTAALGHPGGAGDVQAAPSAALYADQPSAAVLHFTGDSGRSWGALHRVRILGKGSYGCATLYSMKDAASGGVEPTHAVVVKDINMQTMLNPAEEVLAVQNELKVLRTVLGHPNLVQYVDALFDTRPPTYPMSFIMMEYCAGGDLAAVMDGRRSDSATTNGAPSSPPSIPLAITTASTAAGPDILTEPCVASLFIQVAVALQSLHTEYGILHRDVKPHNIFLLEDGITVRLGDFGISTQLDRVGDTAKEACGSPYYMAPELFEERAYGAAADVWSLGVVFYQLIARQLPFTAASAAELRSLVCRGRCTPLHDLQNEAASRYSRQFKELVSSLLTVDAAARPTLRRVLRHKYVRESLKYVPASVLTAKKPLPPARVPSAGAMPSSSLQRFSADGLYAGLFGSDVVEQAVSQAVHAGVYPIVSRVHSA
Atome Classification :
(24 SA)
-------.........10........20........30........40........50........60........70........80........90........100......-------.110.......120.......130.......140...--....150.-......160-.......170.......180.......190...----....200.......210.......220.......230.......240.......250.......260.......270.......280.......290.-----......300.......310---........320.....-.-.330........340.......-350.......360.....------..370--.........380.......390..----.....400...-....410.......420.......430.......440.--.-----.-----...-.450.......460.......470.......480....-...490.......500.......510......-.520.......530
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------MEERF
D
W
M
TFGDDVSGAQAGSAAPPSTGADEDV
P
I
F
L
REDV
G
M
VRAGASHATAASESTGVDSENG
A
P
A
F
L
A
VCPGADVAPRLSGGWSSEGSPVWDGSLRQQQKPSSTA-------ALGHPGGAGDVQAAPSA
A
L
YADQP
S
A
A
V
L
H
F
TGDSGR--SWG
A
L
H
R
V
-
R
I
L
GKGSYG-
C
A
T
L
Y
SMKDAASGGVEP
T
H
A
V
V
V
K
DI
N
M
Q
TML
N
----
P
A
E
E
V
L
A
V
Q
N
E
L
K
V
L
R
T
VLGHP
N
L
V
Q
Y
V
D
A
L
FDTRPPTY
P
M
S
F
I
M
M
E
YCAGG
D
L
A
A
V
MDGRRSDSATTNGAPSSPPS
I
P
L
A
I
T
TASTAAGPDI
L
T
E
P
C
-----
V
A
S
L
F
I
Q
V
A
V
A
L
Q
S
L
H
T
E
----
Y
G
I
L
HRDVKP
H
N
I
F
L
L-E-D
G
I
-
T
V
R
L
GDFGIS
T
Q
L
D
RVG
D
-
T
A
K
E
ACGSPYYM
A
P
E
L
F
E
------
E
RA----YGA
A
A
D
V
W
S
L
G
V
V
F
Y
Q
L
I
A
R
QLPF----TAA
S
A
A
E
L
R
S
L
-
V
CRGRCT
P
L
H
D
L
Q
N
E
A
A
S
R
Y
S
R
Q
F
K
E
L
V
S
S
L
L
TVDAAA--
R
-----
P
-----
T
L
R
-
R
V
L
R
H
K
Y
V
R
E
S
L
K
YV
P
A
S
V
LTAKKPLPPARVPSAGAM
P
-
S
S
S
L
Q
R
FSADGL
Y
A
G
L
F
G
S
D
V
V
E
Q
A
V
S
Q
A
V
H
A
-
G
V
Y
P
I
V
S
R
VHSA
51
Fugue
73.18
19%
8
- C1 -
-
3C4Z
1
RK_BOVIN
A:
[31-533]
-----RD
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
-------
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
PM
G
E
D
W
F
L
D
F
-
R
V
L
G
R
G
G
F
G
---
E
V
F
A
C
Q
M
K
A
T
G
-----
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
----
R
-
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
--
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
----
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
--------------------------
N
V
D
E
D
N
P
G
F
Q
E
P
R
-----
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-----
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
-
D
-
D
G
--
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
-
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
------
G
E
E
----
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
RARG
E
K
V
E
N
K
E
L
K
Q
R
-
V
L
E
Q
A
V
--------
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
--
R
-----
L
GFRDG
S
C
D
-
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
G
A
-
F
S
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-
26
HHSearch
61.24
28%
-22
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[92-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
Q
K
Y
D
P
K
-
D
V
I
G
R
G
V
S
S
-
V
V
--
R
R
C
V
H
R
A
-----
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
L
SPEQ
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
-----
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
------------------------------
A
L
S
E
K
E
-----
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
-----
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
-
D
-
N
M
--
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
-
E
-
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
----
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
----
W
H
R
R
Q
I
L
M
L
R
M
-
I
M
E
G
Q
Y
Q
F
S
----
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
--
R
-----
L
-----
T
A
E
-
Q
A
L
Q
H
P
F
F
E
---------------------------------------------------------------------------
28
HHSearch
59.93
28%
-22
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[92-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
Q
K
Y
D
P
K
-
D
V
I
G
R
G
V
S
S
-
V
--
V
R
R
C
V
H
R
A
-----
T
G
H
E
F
A
V
K
I
M
E
V
---
R
L
SPEQ
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
-----
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
------------------------------
A
L
S
E
K
E
-----
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
-----
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
-
D
-
N
M
--
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
-
E
-
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
----
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
----
W
H
R
R
Q
I
L
M
L
R
M
-
I
M
E
G
Q
Y
Q
F
S
----
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
--
R
-----
L
-----
T
A
E
-
Q
A
L
Q
H
P
F
F
E
---------------------------------------------------------------------------
48
Fugue
59.57
20%
-10
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
KARKGKS
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
GPCKDLF
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
PV
T
K
N
T
F
R
Q
Y
-
R
V
L
G
K
G
G
F
G
-
E
V
C
A
C
Q
V
R
A
-------
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
----
R
-
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
-
N
S
R
F
V
V
S
L
A
Y
A
Y
E
-----
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
----------------------------
G
Q
A
G
F
P
E
A
R
-----
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
-----
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
-
H
G
--
H
I
R
I
S
D
L
G
L
A
V
H
V
P
E
-
G
Q
-
T
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
------
N
E
R
----
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
QQR
K
K
K
I
K
R
E
E
V
E
R
L
-
V
K
E
V
--------
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
--
R
LGCRG
G
-----
S
A
R
-
E
V
K
E
H
P
L
F
K
K
----
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
-
P
D
P
Q
A
I
Y
-
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
-
E
L
N
V
F
G
L
D
G
S
--
33
HHSearch
58.57
28%
-121
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[8-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
F
E
Y
L
-
K
L
L
G
K
G
T
F
G
-
K
V
--
I
L
V
K
E
K
A
-----
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-----
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
-
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
-----
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
------------------------------
V
F
S
E
D
R
-----
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
----
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
-
D
G
--
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
-
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
------
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
----
Y
N
Q
D
H
E
K
L
F
E
L
-
I
L
M
E
E
I
R
--------
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
-----
L
GGGS
E
D
A
K
-
E
I
M
Q
H
R
F
F
A
G
--------------------------------------------------------------------------
40
HHSearch
58.22
26%
-79
- C1 -
-
4WOT
1
ROCK2_HUMAN
B:
[69-338]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
D
V
V
-
K
V
I
G
R
G
A
F
G
-
E
--
V
Q
L
V
R
H
K
A
-----
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
-----
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
-----
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
-------------------------------
V
P
E
K
W
-----
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
-----
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
-
H
G
--
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
------
S
Q
G
GDGF
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
----
Y
A
D
S
L
V
G
T
Y
S
K
-
I
M
D
H
K
N
S
L
----
C
F
P
E
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
-----
N
-----
G
V
E
-
E
I
R
Q
H
P
F
F
K
N
D
-------------------------------------------------------------------------
24
HHSearch
58.05
27%
-126
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[92-349]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
S
Y
L
D
N
F
-
I
K
I
G
E
G
S
T
G
-
I
V
C
--
I
A
T
V
R
S
-----
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
--------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
-
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
-----
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-------------------------------
R
M
N
E
E
Q
-----
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-----
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
-
H
-
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
-
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
------
R
L
P
----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
E
P
P
L
K
A
M
K
M
-
I
R
D
N
L
P
P
R
L
-----
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
-----
A
-----
T
A
A
-
E
L
L
K
H
P
F
L
A
K
--------------------------------------------------------------------------
1
PsiBlast_PDB
57.49
31%
-53
- C1 -
-
2W5A
5
NEK2_HUMAN
A:
[14-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
--------
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
----
A
E
K
Q
M
L
V
--
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
---
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
---------
T
K
G
T
K
E
R
-----------------
Q
Y
L
D
E
E
F
-----
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S------
L
H
R
D
L
K
P
A
N
V
F
L
----
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
-
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
-----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
-
I
R
E
G
K
F
R
R
I
-------
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
-----
P
-----
S
V
E
-
E
I
L
E
N
P
L
I
L
E
--------------------------------------------------------------------------
43
Fugue
57.08
22%
-66
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
--
L
Y
E
K
Y
M
I
A
-
E
D
L
G
R
G
E
F
---
G
I
V
H
R
C
V
E
T
S
S
K
-----
K
T
Y
M
A
K
F
V
K
V
K
---------
G
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
-
A
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
-----
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
F
E
-----------------------------
L
N
E
R
E
-----
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
-----
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
-
R
S
S
-
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
-
G
D
-
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
V
----
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
----
L
A
E
T
N
Q
Q
I
I
E
N
-
I
M
N
A
E
----
Y
T
F
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
--
R
-----
M
-----
T
A
S
-
E
A
L
Q
H
P
W
L
K
Q
K
I
E
R
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
----------------
7
PsiBlast_PDB
56.11
31%
-45
- C1 -
-
2W5B
1
NEK2_HUMAN
A:
[14-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
--------
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
----
A
E
K
Q
M
L
V
--
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
---
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
---------
T
K
G
T
K
E
R
-----------------
Q
Y
L
D
E
E
F
-----
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S------
L
H
R
D
L
K
P
A
N
V
F
L
----
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
N
H
D
T
S
-
F
A
K
A
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
S
----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
-
I
R
E
G
K
F
R
R
I
-------
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
-----
P
-----
S
V
E
-
E
I
L
E
N
P
L
I
L
E
--------------------------------------------------------------------------
15
PsiBlast_PDB
55.75
27%
-49
- C1 -
-
5KBQ
1
PAK1_HUMAN
A:
[10-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
D
P
K
K
--
K
Y
T
R
F
E
K
I
----
G
Q
G
A
S
G
---
T
V
Y
T
A
M
D
V
A
T
G
-----
Q
E
V
A
I
K
Q
M
N
L
Q
Q
--
Q
----
P
K
K
E
L
I
I
--
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
-----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
------------------------------------
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-----
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
-
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
-
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
------
R
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
E
N
P
--
L
R
A
L
Y
L
I
A
T
N
G
T
P
--
E
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
--
R
-----
G
-----
S
A
K
-
E
L
L
Q
H
Q
F
L
K
---------------------------------------------------------------------------
27
HHSearch
55.47
26%
-125
- C1 -
-
4RA5
3
KPCT_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
E
L
H
-
K
M
L
G
K
G
S
F
G
-
K
--
V
F
L
A
E
F
K
K
-----
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-----
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
-----
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
------------------------------
K
F
D
L
S
R
-----
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
-----
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
-
D
G
--
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
-
K
T
N
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
------
G
Q
K
----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
----
H
G
Q
D
E
E
E
L
F
H
S
-
I
R
M
D
N
P
--------
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
-----
L
-----
G
V
R
G
D
I
R
Q
H
P
L
F
R
E
--------------------------------------------------------------------------
5
PsiBlast_PDB
55.36
31%
-51
- C1 -
-
5M51
1
NEK2_HUMAN
A:
[14-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
--------
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
----
A
E
K
Q
M
L
V
--
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
---
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
---------
T
K
G
T
K
E
R
-----------------
Q
Y
L
D
E
E
F
-----
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
SDG
G
H
T
V
L
H
R
D
L
K
P
A
N
V
F
L
----
D
G
K
Q
N
V
K
L
G
D
F
-----------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
S
----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
-
I
R
E
G
K
F
R
R
I
-------
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
-----
P
-----
S
V
E
-
E
I
L
E
N
P
L
I
L
E
--------------------------------------------------------------------------
13
PsiBlast_PDB
55.17
27%
-46
- C1 -
-
5DEY
1
PAK1_HUMAN
A:
[15-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
D
P
K
K
--
K
Y
T
R
F
E
K
I
----
G
Q
G
A
S
G
---
T
V
Y
T
A
M
D
V
A
T
G
-----
Q
E
V
A
I
K
Q
M
N
L
Q
Q
--
Q
----
P
K
K
E
L
I
I
--
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
-----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
------------------------------------
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-----
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
-
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
-
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
------
R
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
E
N
P
--
L
R
A
L
Y
L
I
A
T
N
G
T
P
--
E
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
--
R
-----
G
-----
S
A
K
-
E
L
L
Q
H
Q
F
L
K
---------------------------------------------------------------------------
44
Fugue
54.59
21%
-6
- C1 -
-
1KOB
1
?
A:
[23-374]
--------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
--
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
---
V
V
H
R
C
V
E
K
A
T
G
-----
R
V
F
V
A
K
F
I
N
T
P
--------
Y
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
-
L
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
-----
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
Y
K
-----------------------------
M
S
E
A
E
-----
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
-----
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
-
T
K
K
A
S
-
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
-
D
E
-
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
------
R
E
P
----
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
----
A
G
E
D
D
L
E
T
L
Q
N
-
V
K
R
C
D
----
W
E
F
D
E
D
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
--
R
-----
L
-----
T
V
H
-
D
A
L
E
H
P
W
L
K
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
-
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
-
R
K
E
A
--------
9
PsiBlast_PDB
54.50
31%
-50
- C1 -
-
5M57
1
NEK2_HUMAN
A:
[14-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
--------
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
----
A
E
K
Q
M
L
V
--
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
---
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
---------
T
K
G
T
K
E
R
-----------------
Q
Y
L
D
E
E
F
-----
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
SDGG
H
T
V
L
H
R
D
L
K
P
A
N
V
F
L
----
D
G
K
Q
N
V
K
L
G
D
F
-----------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
S
----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
-
I
R
E
G
K
F
R
R
I
-------
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
-----
P
-----
S
V
E
-
E
I
L
E
N
P
L
I
L
E
--------------------------------------------------------------------------
10
PsiBlast_PDB
54.11
27%
-49
- C1 -
-
4O0R
1
PAK1_HUMAN
A:
[16-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
P
K
K
--
K
Y
T
R
F
E
K
I
----
G
Q
G
A
S
G
---
T
V
Y
T
A
M
D
V
A
T
G
-----
Q
E
V
A
I
K
Q
M
N
L
Q
Q
--
Q
----
P
K
K
E
L
I
I
--
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
-----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
------------------------------------
D
V
V
T
E
T
C
MD
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
----
Q
-
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
-
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
-
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
------
R
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
E
N
P
--
L
R
A
L
Y
L
I
A
T
N
G
T
P
--
E
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
--
R
-----
G
-----
S
A
K
-
E
L
L
Q
H
Q
F
L
K
---------------------------------------------------------------------------
14
PsiBlast_PDB
54.01
27%
-43
- C1 -
-
5DEW
1
PAK1_HUMAN
A:
[15-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
D
P
K
K
--
K
Y
T
R
F
E
K
I
----
G
Q
G
A
S
G
---
T
V
Y
T
A
M
D
V
A
T
G
-----
Q
E
V
A
I
K
Q
M
N
L
Q
Q
--
Q
----
P
K
K
E
L
I
I
--
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
-----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
------------------------------------
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-----
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
-
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
-
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
------
R
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
E
N
P
--
L
R
A
L
Y
L
I
A
T
N
G
T
P
--
E
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
--
R
-----
G
-----
S
A
K
-
E
L
L
Q
H
Q
F
L
K
---------------------------------------------------------------------------
20
PsiBlast_PDB
53.31
26%
-135
- C1 -
-
4I6H
1
PLK2_HUMAN
A:
[32-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
-
K
T
L
G
K
G
--
G
-
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
-----
Y
A
A
K
I
I
P
H
S
R
V
S
K
----
P
H
Q
R
E
-
K
I
D
K
E
I
E
L
H
R
-
I
L
H
H
K
H
V
V
Q
F
Y
H
-
Y
F
E
D
K
E
N
I
Y
----
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
R
K
------------------------------
V
L
T
E
P
E
-----
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
-
E
----
Q
E
I
L
H
R
D
L
K
L
G
N
-
F
F
I
-
N
-
E
S
M
-
E
L
K
V
G
D
F
G
L
A
A
R
L
E
P
L
E
H
-
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
N
------
K
Q
G
----
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
----
E
T
T
N
L
K
E
T
Y
R
S
-
I
R
E
A
R
Y
T
M
P
S
S
L
L
A
P
A
--------
K
H
L
I
A
S
M
L
S
K
N
P
E
D
--
R
-----
P
-----
S
L
D
-
D
I
I
R
H
D
F
-----------------------------------------------------------------------------
12
PsiBlast_PDB
52.99
27%
-44
- C1 -
-
1YHV
-
?
A:
[263-522]
---------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
D
P
K
K
--
K
Y
T
R
F
E
K
I
----
G
Q
G
A
S
G
---
T
V
Y
T
A
M
D
V
A
T
G
-----
Q
E
V
A
I
R
Q
M
N
L
Q
Q
--
Q
----
P
K
K
E
L
I
I
--
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
-----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
------------------------------------
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
----
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
-
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
-
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
------
R
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
E
N
P
--
L
R
A
L
Y
L
I
A
T
N
G
T
P
--
E
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
--
R
-----
G
-----
S
A
K
-
E
L
L
Q
H
Q
F
L
K
---------------------------------------------------------------------------
2
PsiBlast_PDB
49.39
31%
-32
- C1 -
-
2XNM
10
NEK2_HUMAN
A:
[14-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
--------
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
----
A
E
K
Q
M
L
V
--
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
---
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
---------
T
K
G
T
K
E
R
-----------------
Q
Y
L
D
E
E
F
-----
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
---------
R
D
L
K
P
A
N
V
F
L
----
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
----------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
-
S
----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
-
I
R
E
G
K
F
R
R
I
-------
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
-----
P
-----
S
V
E
-
E
I
L
E
N
P
L
I
L
E
--------------------------------------------------------------------------
3
PsiBlast_PDB
47.63
31%
-57
- C1 -
-
2XNO
13
NEK2_HUMAN
A:
[14-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
--------
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
----
A
E
K
Q
M
L
V
--
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
---
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
---------
T
K
G
T
K
E
R
-----------------
Q
Y
L
D
E
E
F
-----
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S--------
R
D
L
K
P
A
N
V
F
L
----
D
G
K
Q
N
V
K
L
G
D
F
----------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
-
I
R
E
G
K
F
R
R
I
-------
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
-----
P
-----
S
V
E
-
E
I
L
E
N
P
L
I
L
E
--------------------------------------------------------------------------
6
PsiBlast_PDB
47.26
31%
-50
- C1 -
-
2JAV
1
NEK2_HUMAN
A:
[14-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
--------
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
----
A
E
K
Q
M
L
V
--
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
----
T
L
---
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
---------
T
K
G
T
K
E
R
-----------------
Q
Y
L
D
E
E
F
-----
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
SD---------
L
K
P
A
N
V
F
L
----
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
S
----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
-
I
R
E
G
K
F
R
R
I
-------
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
-----
P
-----
S
V
E
-
E
I
L
E
N
P
L
I
L
E
--------------------------------------------------------------------------
4
PsiBlast_PDB
44.99
31%
-53
- C1 -
-
2XNP
6
NEK2_HUMAN
A:
[14-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
T
G
-
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
--------
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
----
A
E
K
Q
M
L
V
--
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
---
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
---------
T
K
G
T
K
E
R
-----------------
Q
Y
L
D
E
E
F
-----
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S-------
H
R
D
L
K
P
A
N
V
F
L
----
D
G
K
Q
N
V
K
L
G
D
F
G
L
--------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
-
I
R
E
G
K
F
R
R
I
-------
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
-----
P
-----
S
V
E
-
E
I
L
E
N
P
L
I
L
E
--------------------------------------------------------------------------