@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_03_0200: (2018-03-07 )
MQESNTLIFDVPDAFQVESIIGQGAYGAVCKAVFCDDQIAVKKIPHYSRSEDTARRVLREIEILQNLQFCEQVVGCRLFFRPKSEEKDVYVAMDYIPADLSSVIKNGAITLDESVVRYITCQLLLALRALHRCKVLHRDVSTRNILIHYNSQVFLCDFGLSRFFDPDEQLSFGVVTQWYRAPEIILDAAYSYASDVWSVGVILGELLLRRHLFPGKSNDSANQLQLIFHLVGTPSKDVFDADRSFGRASQNAKNYALAYIERRPCPSTLVNLLSTAPVLHHSAIAAVPPQAVQLAEQLLQFDPAKRPSADEALRHPWFDPCRAFIDEVVQHQDEEEIPVFTQTQNMNVEELVKRIEEVVPVFSEDLLVEDDGGGAAGSA
Atome Classification :
(20 SA)
.........10........20........30..--.--...--..40........50........60........70........80..---.--...--..90........100.....-..110.......120.......130.......140.......150.......160..--.-....-----170.---..----....180.....-.-.-190.......200.......210.......220.......230.......240.......250.......260.......270.......280..-.....290.......300.......310.......320.......330.......340.......350.......360.......370.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQES
N
T
L
I
F
DVP
D
A
F
Q
V
E
S
I
IGQGA
Y
G
A
V
C
K
A
V--F--CDD--
Q
I
A
V
K
KIPHYSR
S
E
D
T
A
R
R
V
L
R
E
I
E
I
L
Q
N
L
Q
F
C
E
Q
V
VG
C
R
L
F
FRPK---S--EEK--
D
V
Y
V
A
M
DYIP
A
D
L
S
S
V
I
KNG-
A
I
T
L
D
E
S
V
V
R
Y
I
T
C
Q
L
L
L
A
L
R
A
L
H
R
C
K
V
L
H
RDVST
R
N
I
L
I
H
YN
S
Q
V
F
L
C
DF
G
L
S
RFF--D-P
D
E
Q
-----
L
S
F
G
---
V
V
----
T
Q
W
YRA
P
E
I
I
L
D
-
A
-
A
-
Y
S
Y
A
S
D
V
W
S
V
G
V
I
L
G
E
L
L
L
R
R
HLFPGKSNDSA
N
Q
L
Q
L
I
F
H
LVGTPS
K
D
V
F
D
A
D
R
SFGRASQNAKN
Y
A
L
A
Y
IERRP
C
P
S
T
L
V
N
L
L
STAPVLHHSAI-AAVP
P
Q
A
V
Q
L
A
E
Q
L
L
QFDPAKRPS
A
D
E
A
LRHP
W
F
D
P
C
R
A
F
I
D
E
V
V
Q
HQDEEEI
P
V
F
T
QTQNM
N
V
E
E
L
V
K
R
I
E
E
V
V
P
VFSE
D
L
L
V
EDDGGGAAGSA
11
PsiBlast_PDB
89.91
36%
-53
- C1 -
-
2B9H
1
FUS3_YEAST
A:
[5-309]
------
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
--
H
KP
T
G
E
--
I
V
A
I
K
K
I
E
P
F
D
K
P
L
-
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
-
E
N
I
I
T
I
F
N
I
Q
R
P
D
---
S
--
F
E
N
FN
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
Q
-
M
L
S
D
D
H
--
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
--
D
------------------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
-
S
-
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
--
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
------
N
D
L
R
C
I
E
S
P
R
--
A
R
E
Y
I
K
S
L
P
-------
M
Y
P
A
A
P
L
--
E
K
M
F
-
P
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
-------------------------------------------------------------
13
PsiBlast_PDB
88.76
36%
-50
- C1 -
-
2B9J
1
FUS3_YEAST
A:
[5-309]
------
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
--
H
KP
T
G
E
--
I
V
A
I
K
K
I
E
P
F
D
K
P
L
-
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
-
E
N
I
I
T
I
F
N
I
Q
R
P
D
---
S
--
F
E
N
FN
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
Q
-
M
L
S
D
D
H
--
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
--
D
------------------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
-
S
-
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
--
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
------
N
D
L
R
C
I
E
S
P
R
--
A
R
E
Y
I
K
S
L
P
-------
M
Y
P
A
A
P
L
--
E
K
M
F
-
P
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
-------------------------------------------------------------
3
PsiBlast_PDB
88.50
36%
-42
- C1 -
-
4ZSG
6
MK07_HUMAN
A:
[1-301]
------
V
T
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
RR
L
--
T
G
Q
--
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
-
D
N
I
I
A
I
K
D
I
L
R
P
T
VPY
G
--
E
F
K
--
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
--
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
CT
S
-
P
A
E
H
-----
Q
Y
F
M
TEY
V
A
----
T
R
W
Y
R
A
P
E
L
M
L
S
-
L
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
--
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
-----
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
W
E
T
V
-------------
Y
-
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
-------------------------------------------------------------
14
PsiBlast_PDB
87.61
36%
-47
- C1 -
-
2F49
-
FUS3_YEAST
A:
[5-309]
------
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
--
H
KP
T
G
E
--
I
V
A
I
K
K
I
E
P
F
D
K
P
L
-
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
-
E
N
I
I
T
I
F
N
I
Q
R
P
D
---
S
--
F
E
N
FN
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
Q
-
M
L
S
D
D
H
--
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
--
D
------------------
V
EFVA
T
R
W
Y
R
A
P
E
V
M
L
T
-
S
-
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
--
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
------
N
D
L
R
C
I
E
S
P
R
--
A
R
E
Y
I
K
S
L
P
-------
M
Y
P
A
A
P
L
--
E
K
M
F
-
P
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
-------------------------------------------------------------
20
PsiBlast_PDB
87.25
33%
-46
- C1 -
-
3HV3
3
MK14_HUMAN
A:
[11-319]
-
Q
E
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
--
D
--
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
-
E
N
V
I
G
L
L
D
V
F
T
P
A
RSL
E
--
E
F
N
--
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
S
Q
-
K
L
T
D
D
H
--
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
-------------------------
V
A
----
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
--
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-----
I
S
S
E
S
A
R
N
Y
--------------
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
----------
A
Q
Y
H
D
P
D
D
E
P
V
----------------------------------------
19
PsiBlast_PDB
87.19
33%
-50
- C1 -
-
3GCV
3
MK14_HUMAN
A:
[11-319]
-
Q
E
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
--
D
--
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
-
E
N
V
I
G
L
L
D
V
F
T
P
A
RSL
E
--
E
F
N
--
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
S
Q
-
K
L
T
D
D
H
--
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
L
C
-----------------------
V
A
----
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
--
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-----
I
S
S
E
S
A
R
N
Y
--------------
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
----------
A
Q
Y
H
D
P
D
D
E
P
V
----------------------------------------
15
PsiBlast_PDB
86.71
36%
-49
- C1 -
-
2FA2
-
FUS3_YEAST
A:
[5-309]
------
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
--
H
KP
T
G
E
--
I
V
A
I
K
K
I
E
P
F
D
K
P
L
-
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
-
E
N
I
I
T
I
F
N
I
Q
R
P
D
---
S
--
F
E
N
FN
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
Q
-
M
L
S
D
D
H
--
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
--
D
------------------
V
EFVA
T
R
W
Y
R
A
P
E
V
M
L
T
-
S
-
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
--
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
------
N
D
L
R
C
I
E
S
P
R
--
A
R
E
Y
I
K
S
L
P
-------
M
Y
P
A
A
P
L
--
E
K
M
F
-
P
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
-------------------------------------------------------------
5
PsiBlast_PDB
86.60
36%
-38
- C1 -
-
4IC7
1
MK07_HUMAN
A:
[49-349]
------
V
T
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
RR
L
--
T
G
Q
--
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
-
D
N
I
I
A
I
K
D
I
L
R
P
T
VPY
G
--
E
F
K
--
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
--
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
CT
S
-
P
A
E
H
-----
Q
Y
F
M
TE
Y
V
A
----
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
-
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
--
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
-----
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
W
E
T
V
-------------
Y
-
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
-------------------------------------------------------------
17
PsiBlast_PDB
86.08
33%
-45
- C1 -
-
3GCQ
2
MK14_HUMAN
A:
[11-319]
-
Q
E
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
--
D
--
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
-
E
N
V
I
G
L
L
D
V
F
T
P
A
RSL
E
--
E
F
N
--
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
S
Q
-
K
L
T
D
D
H
--
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
-------------------------
V
A
----
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
--
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-----
I
S
S
E
S
A
R
N
Y
--------------
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
----------
A
Q
Y
H
D
P
D
D
E
P
V
----------------------------------------
16
PsiBlast_PDB
85.21
33%
-39
- C1 -
-
3GCP
3
MK14_HUMAN
A:
[11-319]
-
Q
E
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
--
D
--
T
K
T
GL
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
-
E
N
V
I
G
L
L
D
V
F
T
P
A
RSL
E
--
E
F
N
--
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
S
Q
-
K
L
T
D
D
H
--
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
L
C
-----------------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
--
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-----
I
S
S
E
S
A
R
N
Y
--------------
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
----------
A
Q
Y
H
D
P
D
D
E
P
V
----------------------------------------
4
PsiBlast_PDB
84.90
36%
-40
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[2-300]
--------
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
RR
L
--
T
G
Q
--
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
-
D
N
I
I
A
I
K
D
I
L
R
P
T
VPY
G
--
E
F
K
--
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
--
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
CT
S
-
P
A
E
H
-----
Q
Y
F
M
TEY
V
A
----
T
R
W
Y
R
A
P
E
L
M
L
S
-
L
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
--
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
-----
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
W
E
T
V
-------------
Y
-
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
-------------------------------------------------------------
10
PsiBlast_PDB
83.16
36%
-39
- C1 -
-
4ZSJ
5
MK07_HUMAN
A:
[1-298]
---------
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
RR
L
--
T
G
Q
--
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
-
D
N
I
I
A
I
K
D
I
L
R
P
T
VPY
G
--
E
F
K
--
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
--
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
CT
S
-
P
A
E
H
-----
Q
Y
F
M
TEY
V
A
----
T
R
W
Y
R
A
P
E
L
M
L
S
-
L
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
--
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
-----
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
W
E
T
V
-------------
Y
-
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
-------------------------------------------------------------
12
PsiBlast_PDB
83.12
36%
-34
- C1 -
-
2B9I
1
FUS3_YEAST
A:
[5-309]
------
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
--
H
KP
T
G
E
--
I
V
A
I
K
K
I
E
P
F
D
K
P
L
-
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
-
E
N
I
I
T
I
F
N
I
Q
R
P
D
---
S
--
F
E
N
FN
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
Q
-
M
L
S
D
D
H
--
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
--
D
E-----------------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
-
S
-
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
--
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
------
N
D
L
R
C
I
E
S
P
R
--
A
R
E
Y
I
K
S
L
P
-------
M
Y
P
A
A
P
L
--
E
K
M
F
-
P
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
-------------------------------------------------------------
1
PsiBlast_PDB
83.07
36%
-41
- C1 -
-
4B99
1
MK07_HUMAN
A:
[48-348]
------
V
T
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
--
T
G
Q
--
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
-
D
N
I
I
A
I
K
D
I
L
R
P
T
VPY
G
--
E
F
K
--
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
--
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
-------------
Q
Y
F
M
TEY
V
A
----
T
R
W
Y
R
A
P
E
L
M
L
S
-
L
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
--
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
----------
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
W
E
T
V
-------------
Y
-
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
-------------------------------------------------------------
43
HHSearch
82.98
35%
-32
* C1 *
-
4ZZN
1
MK01_HUMAN
A:
[8-316]
-------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
--
D
NL
N
K
V
--
R
V
A
I
K
K
I
S
P
F
E
H
-
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
-
E
N
I
I
G
I
N
D
I
I
R
A
P
---
T
IE
Q
M
K
--
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
Q
---
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
--
D
-
P
D
H
D
H
T
G
F-
L
T
E
Y
---
V
A
----
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
-
G
-
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
--
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
D
L
N
C
I
I
N
L
-----
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
-
V
P
W
------------
N
R
L
F
-
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
------------------------------------------------------
21
HHSearch
82.86
38%
-28
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[2-309]
--------
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
--
R
RL
T
G
Q
--
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
-
D
N
I
I
A
I
K
D
I
L
R
P
T
VPY
G
--
E
F
K
--
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
--
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
--
C
-
T
S
P
A
EHQYF
M
T
E
Y
---
V
A
----
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
-
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
--
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
-----
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
-------------
P
V
P
W
E
T
V
Y
-
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
----------------------------------------------------
9
PsiBlast_PDB
82.46
36%
-39
- C1 -
-
2B9F
1
FUS3_YEAST
A:
[5-309]
------
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
--
H
KP
T
G
E
--
I
V
A
I
K
K
I
E
P
F
D
K
P
L
-
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
-
E
N
I
I
T
I
F
N
I
Q
R
P
D
---
S
--
F
E
N
FN
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
Q
-
M
L
S
D
D
H
--
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
--
D
-----------
T
E
Y
---
V
A
----
T
R
W
Y
R
A
P
E
V
M
L
T
-
S
-
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
--
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
------
N
D
L
R
C
I
E
S
P
R
--
A
R
E
Y
I
K
S
L
P
-------
M
Y
P
A
A
P
L
--
E
K
M
F
-
P
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
-------------------------------------------------------------
8
PsiBlast_PDB
82.38
36%
-37
- C1 -
-
2F9G
1
FUS3_YEAST
A:
[5-309]
------
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
--
H
KP
T
G
E
--
I
V
A
I
K
K
I
E
P
F
D
K
P
L
-
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
-
E
N
I
I
T
I
F
N
I
Q
R
P
D
---
S
--
F
E
N
FN
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
Q
-
M
L
S
D
D
H
--
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
--
D
-----------------------
T
R
W
Y
R
A
P
E
V
M
L
T
-
S
-
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
--
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
------
N
D
L
R
C
I
E
S
P
R
--
A
R
E
Y
I
K
S
L
P
-------
M
Y
P
A
A
P
L
--
E
K
M
F
-
P
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
-------------------------------------------------------------
18
PsiBlast_PDB
81.21
33%
-39
- C1 -
-
3GCS
2
MK14_HUMAN
A:
[11-319]
-
Q
E
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
---
Y
G
S
V
C
A
A
F
--
D
--
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
-
E
N
V
I
G
L
L
D
V
F
T
P
A
RSL
E
--
E
F
N
--
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
S
Q
-
K
L
T
D
D
H
--
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
-------------------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
--
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-----
I
S
S
E
S
A
R
N
Y
--------------
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
----------
A
Q
Y
H
D
P
D
D
E
P
V
----------------------------------------
2
PsiBlast_PDB
81.13
36%
-34
- C1 -
-
5BYY
1
MK07_HUMAN
A:
[1-299]
--------
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
--
T
G
Q
--
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
-
D
N
I
I
A
I
K
D
I
L
R
P
T
VPY
G
--
E
F
K
--
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
--
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
--------------
Y
F
M
TEY
V
A
----
T
R
W
Y
R
A
P
E
L
M
L
S
-
L
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
--
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
-----
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
W
E
T
V
-------------
Y
-
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
-------------------------------------------------------------