@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_05_0130: (2018-03-07 )
MTSLPFPLIEDIGELYMLDDIYDFLGEGTFASVFKAVSTTNRDVVQENQTVALKMIAKRNLSSDKLVRDVINEVHVLRQTAHPNCVRFIECVQTPVYVVIVTEYIEGVELFQALKDQKFTEAMVLNVMRQLLSALAYLHNTLHIVHRDVKPENVIISTHEAPFRVVLVDFGLARSCERKRPRISRELATHFQRQRPIPVRNMSVESLDCDSPMLATPCGTLKYAAPETVQSITQSAQLSTTKNLLSRLDVYAAGIIMYVMLSGALPFKNFANKASLVMEMRNSLSFEGPRWAGISAEAIDLNKALLNFDAVSRPHAAEALQYPWFKIYGSALRPLSTEEAQSTPGIPLDSSICERGAMTHAFEAMRATEAALYYNEEETASTSAPVTSHSGLRTPNSRCVSVPFGTNTSAFSNSSSTTTAAQTAQSGYFDFA
Atome Classification :
(20 SA)
------------.........10........20........30........40........50........60..---......70........80........90........100.......110...--.-.-.-----..120.......130.......140.......150.......160........170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280..-.-.-....290.......300.......310--.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------MTSLP
F
P
L
I
E
D
I
G
E
L
Y
M
L
D
D
I
Y
D
F
LGE
G
T
F
A
S
V
F
K
A
V
STTN
R
D
V
VQENQ
T
V
A
L
K
M
I
A
KRNL
S
S
---
D
K
L
V
R
D
V
I
N
E
V
H
V
L
R
QTAH
P
N
C
V
R
F
I
E
C
VQT
P
V
Y
V
V
I
V
T
E
Y
I
E
G
V
E
L
F
-
Q
A
L
--
K
-D-Q-----K
F
T
E
A
M
V
L
N
V
M
R
Q
L
L
S
A
L
A
Y
L
H
N
T
L
H
I
V
HRDVKPE
N
V
I
I
STHE-A
P
F
R
V
V
L
V
DFGL
A
R
S
C
E
RKRP
R
I
S
R
E
L
A
T
H
F
Q
RQRPIPVRNMSVESLDCDSPMLATPCGTLKYAA
P
E
T
V
Q
S
I
T
Q
SAQ
L
S
T
T
K
N
L
L
S
R
L
D
V
Y
A
A
G
I
I
M
Y
V
M
LSGAL
P
F
K
N
F
A
N
K
A
S
L
V
M
E
M
-
R
N
S-L-S-FEGPRWAG
I
S
A
E
A
I
D
L
N
K
A
L
L
N
F
D
AVS--RPH
A
A
E
A
LQ
Y
P
W
F
K
I
Y
G
S
ALRPLS
T
E
EAQSTPGIPL
D
S
S
I
C
ERG
A
M
T
H
A
F
E
A
M
R
A
T
E
A
A
L
Y
YNEEETASTSAPVTSHSGLRTPNS
R
C
V
S
VPFGTNTSAFSNSSST
T
T
A
A
QTAQSGYFDFA
27
HHSearch
74.53
27%
-65
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[5-275]
--------------------
S
T
K
F
S
D
N
Y
D
V
K
---
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
------
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
S
A
----
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
-
E
D
I
--
V
A
R
-
E
-----
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
-
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
A
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
N
D
S
--------------------------------
E
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
----------
D
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
-
R
L
Y
A
Q
I
-
K
A
G
-
A
Y
D
-
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
--
R
I
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
E
-------------------------------------------------------------------------------------------------------
35
HHSearch
74.17
30%
-72
- C1 -
-
5IG1
-
?
A:
[23-280]
----------------------------------
S
V
I
G
K
G
A
F
S
T
V
H
R
C
V
N
K
------
R
T
G
E
V
C
A
V
K
V
I
A
L
K
S
L
R
S
----
S
E
I
N
K
I
K
R
E
I
G
I
C
S
S
L
Q
H
E
H
I
V
S
M
R
R
A
F
R
D
E
S
H
F
Y
L
V
F
E
Y
V
S
G
G
E
L
F
-
D
E
I
--
V
T
R
-
K
-----
F
Y
N
E
K
D
A
S
A
C
M
H
Q
I
L
S
A
L
Q
H
C
H
S
-
K
N
I
I
H
R
D
L
K
P
E
N
L
L
L
A
S
K
D
-
P
N
A
P
V
K
I
T
D
F
G
L
A
V
I
M
E
Q
G
P
--------------------------------
T
Y
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
I
R
R
----------
V
P
Y
D
T
A
V
D
V
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
E
E
D
H
Q
-
K
L
Y
A
Q
I
-
K
N
C
-
Q
Y
D
-
F
P
S
P
E
W
D
S
V
T
T
A
A
K
E
L
I
K
A
M
L
E
P
N
P
K
R
--
R
P
T
V
Q
E
L
L
Q
H
P
W
I
A
R
R
D
-------------------------------------------------------------------------------------------------------
22
HHSearch
74.17
29%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[2-272]
-----------------------
M
T
D
E
Y
Q
L
F
---
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
------
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
----
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
-
E
D
I
--
V
A
R
-
E
-----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
-------------------------------
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
----------
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
-
R
L
Y
Q
Q
I
-
K
A
G
-
A
Y
D
-
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
--
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
-------------------------------------------------------------------------------------------------------
41
HHSearch
74.05
30%
-68
- C1 -
-
5IG1
-
?
B:
[23-280]
----------------------------------
S
V
I
G
K
G
A
F
S
T
V
H
R
C
V
N
K
------
R
T
G
E
V
C
A
V
K
V
I
A
L
K
S
L
R
S
----
S
E
I
N
K
I
K
R
E
I
G
I
C
S
S
L
Q
H
E
H
I
V
S
M
R
R
A
F
R
D
E
S
H
F
Y
L
V
F
E
Y
V
S
G
G
E
L
F
-
D
E
I
--
V
T
R
-
K
-----
F
Y
N
E
K
D
A
S
A
C
M
H
Q
I
L
S
A
L
Q
H
C
H
S
-
K
N
I
I
H
R
D
L
K
P
E
N
L
L
L
A
S
K
D
-
P
N
A
P
V
K
I
T
D
F
G
L
A
V
I
M
E
Q
G
--------------------------------
P
T
Y
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
I
R
R
----------
V
P
Y
D
T
A
V
D
V
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
E
E
D
H
Q
-
K
L
Y
A
Q
I
-
K
N
C
-
Q
Y
D
-
F
P
S
P
E
W
D
S
V
T
T
A
A
K
E
L
I
K
A
M
L
E
P
N
P
K
R
--
R
P
T
V
Q
E
L
L
Q
H
P
W
I
A
R
R
D
-------------------------------------------------------------------------------------------------------
26
HHSearch
73.86
25%
-117
- C1 -
-
4WOT
1
ROCK2_HUMAN
B:
[69-340]
-------------------------
E
D
Y
D
V
V
---
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
------
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
---
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
--
S
-
N
-
Y
-----
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
----
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
------------------------------
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
------
D
G
F
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
-
G
T
Y
S
K
I
-
M
D
H
-
K
N
S
-
L
C
F
P
E
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
G
V
E
E
I
R
Q
H
P
F
F
K
N
D
Q
W
------------------------------------------------------------------------------------------------------
40
HHSearch
72.87
24%
-114
- C1 -
-
3V8S
1
ROCK1_HUMAN
D:
[68-338]
------------------------
A
E
D
Y
E
V
V
---
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
------
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
---
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
--
S
-
N
-
Y
-----
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
----
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
------------------------------
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
------
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
-
G
T
Y
S
K
I
-
M
N
H
K
N
-
S
-
L
T
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
------------------------------------------------------------------------------------------------------
37
HHSearch
72.06
25%
-135
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[100-350]
----------------------------------
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
------
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
-
D
I
V
--
T
-
H
-
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
----
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
-------------------------------
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
----------
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
-
K
A
M
K
M
I
-
R
D
N
-
L
-
P
-
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
--------------------------------------------------------------------------------------------------------
23
HHSearch
71.52
28%
-47
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[20-294]
---------------------
V
L
F
E
D
V
Y
E
L
C
---
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
------
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP-
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
-
F
E
I
--
V
-
K
-
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
-------------------------------
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
----------
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
--
R
L
F
E
G
I
-
I
K
G
-
K
-
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
-------------------------------------------------------------------------------------------------------
24
HHSearch
70.03
28%
-45
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[20-294]
---------------------
V
L
F
E
D
V
Y
E
L
C
---
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
------
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP-
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
-
F
E
I
--
V
-
K
-
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
-------------------------------
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
----------
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
--
R
L
F
E
G
I
-
I
K
G
-
K
-
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
-------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
69.62
28%
-54
- C1 -
-
3UPX
1
?
A:
[34-307]
------------------------------------
L
G
K
G
S
F
G
E
V
I
L
C
-----
K
D
K
I
T
-
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
---
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
-
R
-
K
-----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
---------------
T
H
F
E
A
-----------------
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
-----------
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
-
Y
-
T
-
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
69.59
28%
-57
- C1 -
-
3KU2
1
?
A:
[57-318]
------------------------------------
L
G
K
G
S
F
G
E
V
I
L
C
-----
K
D
K
I
T
-
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
---
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
-
R
-
K
-----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
---------------
T
H
F
E
A
-----------------
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
-----------
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
-
Y
-
T
-
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------------------------------------------------------------------------------------------------
29
HHSearch
69.55
31%
-18
* C1 *
-
2X0G
-
DAPK1_HUMAN
A:
[6-278]
--------------------
Q
E
N
V
D
D
Y
Y
D
T
G
---
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
------
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
SRR
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
-
D
F
L
--
A
-
E
K
E
-----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
--------------------------------
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
----------
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
-
A
N
V
-
S
A
V
-
N
Y
E
-
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
--
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
--------------------------------------------------------------------------------------------------------
43
Fugue
69.45
27%
15
- C1 -
-
1KOB
1
?
A:
[23-374]
INDYDKFYEDIW
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
------
G
R
V
F
V
A
K
F
I
N
T
P
---
Y
---
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
-
D
R
I
A
A
E
-
D
-
Y
-----
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
-
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
K
-
A
S
-
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
I
--------------------------------
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
R
----------
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
D
D
L
E
T
L
Q
N
V
K
-
R
C
D
-
W
-
E
-
F
D
E
D
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
--
R
L
T
V
H
D
A
L
E
H
P
W
---------------------
L
K
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
----
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
----------------
15
PsiBlast_PDB
69.03
28%
-51
- C1 -
-
3N51
3
?
A:
[34-303]
------------------------------------
L
G
K
G
S
F
G
E
V
I
L
C
-----
K
D
K
I
T
-
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
---
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
-
R
-
K
-----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
---------------
T
H
F
E
A
-----------------
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
-----------
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
-
Y
-
T
-
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
68.94
28%
-58
- C1 -
-
5T6K
1
?
A:
[75-360]
------------------------------------
L
G
K
G
S
F
G
E
V
I
L
C
-----
K
D
K
I
T
-
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
---
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
-
R
-
K
-----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
---------------
T
H
F
E
A
------------------
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
-----------
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
-
Y
-
T
-
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
68.90
28%
-55
- C1 -
-
4IHP
1
?
A:
[57-321]
------------------------------------
L
G
K
G
S
F
G
E
V
I
L
C
-----
K
D
K
I
T
-
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
---
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
-
R
-
K
-----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
---------------
T
H
F
E
A
-----------------
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
-----------
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
-
Y
-
T
-
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
68.50
28%
-54
- C1 -
-
5JMS
2
?
A:
[75-346]
------------------------------------
L
G
K
G
S
F
G
E
V
I
L
C
-----
K
D
K
I
T
-
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
---
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
-
R
-
K
-----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
---------------
T
H
F
E
A
-----------------
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
-----------
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
-
Y
-
T
-
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
68.19
28%
-52
- C1 -
-
5JN2
1
?
A:
[75-344]
------------------------------------
L
G
K
G
S
F
G
E
V
I
L
C
-----
K
D
K
I
T
-
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
---
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
-
R
-
K
-----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
---------------
T
H
F
E
A
-----------------
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
-----------
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
-
Y
-
T
-
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------------------------------------------------------------------------------------------------
39
HHSearch
67.92
31%
-17
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[7-281]
-------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
---
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
------
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
SRR
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
-
D
F
L
--
A
-
E
K
E
-----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
--------------------------------
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
----------
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
-
L
A
N
V
-
S
A
V
-
N
Y
E
-
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
--
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
-------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
67.41
28%
-51
- C1 -
-
4IFG
1
?
A:
[57-323]
------------------------------------
L
G
K
G
S
F
G
E
V
I
L
C
-----
K
D
K
I
T
-
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
---
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
-
R
-
K
-----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
---------------
T
H
F
E
A
-----------------
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
-----------
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
-
Y
-
T
-
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------------------------------------------------------------------------------------------------