@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_08_1250: (2018-03-08 )
MRDAAATERERLPTPADGDVDSLYEDGTEAETAKQRSTVSTTTLFLALPWLGCTLFLVAVLLYVNVHTFSIWSRLVSMPGGVVADVSVQHRDMARYTVLFVSLALLAVHLAISFCLFRRAYHVLWDVQMSLVELSFMVDVIRTHQHSTFFFVDCVERAQRVRESMRYWVKEFSGFKEICAAEMAVNQVTLRLMTRPRESAQRLESPGDTQLPCTGSGTSSPVQLARGGRLPPDTTAAAFRLPQDAAWSPHVQSVRTDSAHADPGPGRQLAGHHSGSRRSLSFTTEIGIAQVPFEVTLKRRHVALLLLSFLTYRELVRAEAEEARQISRDFIAAVNMCAQRYKGCIVELYSDRAILSWNAFFESAGNYAQTCAQCGECFHDRFVRRFSPESGAYFSTAGYTGHIVCGTTTEKSLLLHGQHVSMLRGLPTLLEMRYCAYVWLGTPPPACTSSPLSWTRIGAVQAGADFSVDLHAMRRTSAEPLPAAMVWHMPQWTTFGDERAVRAEVLTNDGAARLQQDGDTAPVTPASTAASAAATGVATAFPSSPFLSSPLCLRGVGTPYETFYDRSHNRYQLSNTVLGESKSCVVRLAISETGNFVAVKEIKIERGDVKPIRRRRYQRENRIIVTRGEKPQWMNEVEIMERHRHTCIVAYISFVEAEDKLRIVMEYVGGGNLLKFASSSRGAEGEGPPMAVLLRNVVEGLKFLHQKGIVHGDIKPQNVLVPDSGPCKIADFGISRRATTAVTSAIEGTPFYMSPEATRGEVTAACDIWSFGIMMAQVLTGRLPYDASVRDYYLVSQFMCNKDVKRELHTPLKKPALDVFLACTEYDPGKRKTAKDLLKMPYFTAHAASSTEDA
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580-........590.-.......600.......610.......620.......630.......640.-......650.......660.......670.......680.--......690.......700.......710.......720..----.----....730.......740-------.--..--......750....-...-------760.........770.......780...--....790-.--.....-.800......--..810.....--..820.......830.......840.......850..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRDAAATERERLPTPADG
D
V
D
S
L
YEDGTE
A
E
T
A
KQRSTV
S
T
T
T
L
F
L
A
L
P
W
L
G
C
T
L
F
L
V
A
V
L
L
Y
V
NV
H
T
F
S
I
W
S
R
L
V
SMPG
G
V
V
A
D
V
S
V
Q
H
R
D
M
A
R
Y
T
V
L
F
V
S
L
A
L
L
A
V
H
L
A
I
S
F
C
L
F
R
R
A
Y
H
V
L
W
D
V
Q
M
S
L
V
E
L
S
F
M
V
D
V
I
R
THQHS
T
F
F
F
V
D
C
V
E
R
A
Q
R
V
R
E
S
M
R
Y
W
V
K
E
FS
G
F
K
E
I
C
A
A
E
M
A
V
N
Q
V
T
L
R
L
MTR
P
R
E
S
A
Q
RLESPGDTQLPCTGSGTSS
P
V
Q
LARGGRLPPDTT
A
A
A
F
RLPQDAAWSP
H
V
Q
SVRTDSAHADPGPGRQLAGHHSGSR
R
S
L
S
F
TTEIGIAQV
P
F
E
V
T
L
K
R
R
H
V
A
L
L
L
L
S
F
L
T
Y
R
E
L
V
R
A
E
A
E
E
A
R
Q
I
S
R
D
F
I
A
A
V
N
M
C
A
Q
R
Y
K
G
C
I
V
E
LYSD
R
A
I
L
S
W
N
A
F
F
ESAG
N
Y
A
Q
T
C
A
Q
C
G
E
C
F
H
D
R
F
V
R
RFSPESG
A
Y
F
STAGY
T
G
H
I
V
CGTTTE
K
S
L
L
LHG
Q
H
V
S
M
L
RG
L
P
T
L
L
E
M
R
Y
C
A
Y
V
W
LGTPPPACTSSPL
S
W
T
R
I
G
A
V
QAGA
D
F
S
V
D
L
H
A
M
RRTSAEPL
P
A
A
M
V
WHMPQWTTFGDER
A
V
R
A
E
V
LTNDG
A
A
R
L
QQDGDTAPVTPASTA
A
S
A
AATGVATAFPSSPFLSSP
L
C
LRGVGT
P
Y
E
T
F
Y
DRSH
N
R
Y
Q
LSNTVLGES--K
S
C
V
V
R
L
A
IS-E-TG
N
F
V
A
V
K
E
I
K
IERGD
V
K
P
I
R
R
R
R
YQREN
R
I
I
V
TRGEKP
Q
W
M
N
E
V
E
I
M
E
R
H-R
H
T
C
I
V
A
Y
I
S
F
VEA
E
D
K
L
R
I
V
M
E
YVGGG
N
L
L
K
FASSSRGA--EGEGP
P
M
A
V
L
L
R
N
V
V
E
G
L
K
F
L
H
QKGIVHGDIKPQ
N
V
LVPDS----G----P
C
K
I
A
DFGISR
R
A
T
T
---------
A
--
V
T
--
S
AIEGT
P
F
YMSPE-ATR-------G--
E
V
T
A
A
C
D
I
W
S
F
G
I
M
M
A
Q
V
L
TGRLPY--DAS
V
R
D
Y
-
Y
--
L
V
S
Q
F
-
M
C-
N
K
D
V
K
R
E
--
L
HTPLKKPA
L
--
D
V
F
L
A
CTEYDPGK
R
K
T
A
K
D
L
L
KMP
Y
F
TAHAASSTEDA
40
HHSearch
72.32
26%
-43
- C1 -
-
5K00
1
MELK_HUMAN
A:
[5-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
-
I
G
T
G
----
A
K
V
K
L
A
C
H
I
L
-
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
-------------------
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
-
R
--
L
S
-
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
----
H
----
K
L
K
L
I
D
F
G
L
C
A
K
P
-----------------------
S
L
A
Y
A
A
P
E
-
L
I
Q
-------
G
KS
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
D
N
V
M
A
-
L
---
Y
K
K
I
-
M
----
R
G
K
Y
D
--
V
P
K
W
L
S
P
S
S
I
--
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
------
13
PsiBlast_PDB
70.66
29%
-55
- C1 -
-
5IME
1
PAK1_HUMAN
A:
[28-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
-----
Q
E
V
A
I
K
Q
M
N
L
----------------
K
E
L
I
I
---------
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
--
E
G
Q
---
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
----
G
----
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
---------
E
--
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-------
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
LN
E
N
P
L
R
A
L
-
Y
--
L
I
A
-------
T
N
G
T
P
E
--
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-----------
2
PsiBlast_PDB
68.57
30%
-43
- C1 -
-
4ZJJ
1
PAK1_HUMAN
A:
[30-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
---------------
K
E
L
I
I
---------
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
--
E
G
Q
---
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
----
G
----
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
------------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-------
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
LN
E
N
P
L
R
A
L
-
Y
--
L
I
A
-------
T
N
G
T
P
E
--
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-----------
18
PsiBlast_PDB
68.28
29%
-21
- C1 -
-
5DEY
1
PAK1_HUMAN
A:
[28-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-----------
Q
P
K
K
E
L
I
I
---------
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
--
E
G
Q
---
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
----
G
----
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
---------
E
--
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-------
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
LN
E
N
P
L
R
A
L
-
Y
--
L
I
A
-------
T
N
G
T
P
E
--
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-----------
36
HHSearch
68.02
30%
-33
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[3-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
D
F
E
L
I
Q
R
-
I
G
S
G
--
T
Y
G
D
V
Y
K
A
R
N
V
N
-
T
G
E
L
A
A
I
K
V
I
K
L
E
P
G
--------------------
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
G
-
P
--
L
S
-
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
N
----
G
----
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
---------
T
IA-----
A
F
I
G
T
P
Y
W
M
A
P
E
-
V
A
A
V
ERK---
G
--
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
--
F
D
L
H
P
M
R
-
A
--
L
F
L
M
T
-
K
--
S
N
F
Q
P
P
K
LK
D
K
M
K
W
S
N
S
F
H
--
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
V
T
Q
H
L
-------
19
PsiBlast_PDB
67.59
29%
-19
- C1 -
-
5DEW
1
PAK1_HUMAN
A:
[28-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-----------
Q
P
K
K
E
L
I
I
---------
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
--
E
G
Q
---
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
----
G
----
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
---------
E
--
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-------
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
LN
E
N
P
L
R
A
L
-
Y
--
L
I
A
-------
T
N
G
T
P
E
--
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-----------
46
HHSearch
67.49
26%
-38
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-351]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
Y
L
D
N
F
I
K
-
I
G
E
G
--
S
T
G
I
V
C
I
A
T
V
-
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
--------------------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
--
R
--
M
N
-
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
----
G
----
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
---------
E
VP
R
R
--
K
S
L
V
G
T
P
Y
W
M
A
P
E
-
L
I
S
R------
L
--
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
--
F
N
E
P
P
L
K
-
A
M
K
M
I
R
D
N
-
L
----
P
P
R
L
K
--
N
L
H
K
V
S
P
S
L
K
--
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
-------
12
PsiBlast_PDB
66.55
29%
-24
- C1 -
-
4O0T
1
PAK1_HUMAN
A:
[28-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-----------
Q
P
K
K
E
L
I
I
---------
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
--
E
G
Q
---
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
----
G
----
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
---------
E
--
Q
S
KR
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-------
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
LN
E
N
P
L
R
A
L
-
Y
--
L
I
A
-------
T
N
G
T
P
E
--
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-----------
32
HHSearch
66.20
24%
-17
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[10-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
-
L
G
S
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
--------------
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-
S
--
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
----
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G--------
N
--
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
-
I
V
N
Y------
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
G
D
T
K
Q
E
-
T
--
L
A
N
V
S
-
A
V
-
N
Y
E
F
E
D
E
--
Y
F
S
N
T
S
A
L
A
K
--
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
-----
11
PsiBlast_PDB
66.08
29%
-23
- C1 -
-
4O0R
1
PAK1_HUMAN
A:
[28-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-----------
Q
P
K
K
E
L
I
I
---------
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
--
E
G
Q
---
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
----
G
----
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
---------
E
--
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-------
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
LN
E
N
P
L
R
A
L
-
Y
--
L
I
A
-------
T
N
G
T
P
E
--
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-----------
1
PsiBlast_PDB
65.26
30%
-38
- C1 -
-
4ZJI
1
PAK1_HUMAN
A:
[30-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
Q
M
N
L
----------------
K
E
L
I
I
---------
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
--
E
G
Q
---
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
----
G
----
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
-----------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-------
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
LN
E
N
P
L
R
A
L
-
Y
--
L
I
A
-------
T
N
G
T
P
E
--
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-----------
35
HHSearch
63.93
23%
-26
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[21-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
E
D
V
Y
E
L
C
E
V
-
I
G
K
G
--
P
F
S
V
V
R
R
C
I
N
R
E
-
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
---------------
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
ENS-
A
----
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
---------
S
G
L
V
A
--
G
G
R
V
G
T
P
H
F
M
A
P
E
-
V
V
K
R------
E
--
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
--
Y
G
T
K
E
R
L
F
E
--
G
I
I
K
G
-
K
---
Y
K
M
N
P
R
--
Q
W
S
H
I
S
E
S
A
K
--
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
-------
8
PsiBlast_PDB
63.76
29%
-22
- C1 -
-
4ZY4
1
PAK1_HUMAN
A:
[29-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
-----
Q
-----------
Q
P
K
K
E
L
I
I
---------
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
--
E
G
Q
---
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
----
G
----
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
---------
E
--
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-------
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
LN
E
N
P
L
R
A
L
-
Y
--
L
I
A
-------
T
N
G
T
P
E
--
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-----------
10
PsiBlast_PDB
63.75
29%
-24
- C1 -
-
4ZY6
1
PAK1_HUMAN
A:
[29-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
-----------------
Q
P
K
K
E
L
I
I
---------
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
--
E
G
Q
---
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
----
G
----
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
---------
E
--
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-------
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
LN
E
N
P
L
R
A
L
-
Y
--
L
I
A
-------
T
N
G
T
P
E
--
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-----------
9
PsiBlast_PDB
63.52
29%
-24
- C1 -
-
4ZY5
1
PAK1_HUMAN
A:
[29-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
-----
Q
-----------
Q
P
K
K
E
L
I
I
---------
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
---
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
--
E
G
Q
---
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
----
G
----
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
---------
E
--
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-------
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
LN
E
N
P
L
R
A
L
-
Y
--
L
I
A
-------
T
N
G
T
P
E
--
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-----------
34
HHSearch
63.42
23%
-27
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[21-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
E
D
V
Y
E
L
C
E
V
-
I
G
K
G
--
P
F
S
V
V
R
R
C
I
N
R
E
-
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
---------------
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
ENS-
A
----
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
---------
S
GL
V
A
--
G
G
R
V
G
T
P
H
F
M
A
P
E
-
V
V
K
R------
E
--
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
--
Y
G
T
K
E
R
L
F
E
--
G
I
I
K
G
-
K
---
Y
K
M
N
P
R
--
Q
W
S
H
I
S
E
S
A
K
--
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
-------
31
HHSearch
62.82
24%
-6
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[92-364]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
Q
K
Y
D
P
K
D
V
-
I
G
R
G
--
V
S
S
V
V
R
R
C
V
H
-
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---
R
L
S
P
--------
E
----
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
-
A
--
L
S
-
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
----
M
----
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
---------
G
E-
K
L
--
R
E
L
C
G
T
P
G
Y
L
A
P
E
-
I
L
K
CSMDETH
P
--
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
--
W
H
R
R
Q
I
L
-
M
LR
M
I
M
E
G
-
Q
---
Y
Q
F
S
S
P
--
E
W
D
D
R
S
S
T
V
K
--
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
----------
30
HHSearch
62.51
24%
-15
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[8-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
-
L
G
S
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
--------------
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-
S
--
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
NVP
K
P
----
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G--------
N
--
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
-
I
V
N
Y------
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
G
D
T
K
Q
E
-
T
--
L
A
N
V
S
-
A
V
-
N
Y
E
F
E
D
E
--
Y
F
S
N
T
S
A
L
A
K
--
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
------
38
HHSearch
62.38
23%
-18
- C1 -
-
1KOB
1
?
A:
[49-312]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
D
Y
Y
D
I
L
E
E
-
L
G
S
G
--
A
F
G
V
V
H
R
C
V
E
K
A
-
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
P
L
--------------------
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
Y
K
--
M
S
-
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
KA--
S
----
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
---------
D
E
-
I
V
--
K
V
T
T
A
T
A
E
F
A
A
P
E
-
I
V
D
R------
E
--
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
--
A
G
E
D
D
L
E
-
T
--
L
Q
N
V
K
-
R
C
-
D
W
E
F
D
E
D
--
A
F
S
S
V
S
P
E
A
K
--
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
-------
25
HHSearch
61.54
20%
-30
- C1 -
-
2WTK
1
STRAA_HUMAN
B:
[8-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
C
Y
E
L
L
T
V
-
I
G
K
G
FE
D
L
M
T
V
N
L
A
R
Y
K
P
-
T
G
E
Y
V
T
V
R
R
I
N
L
E
A
C
S
------------------
N
E
M
V
T
F
L
Q
G
E
L
H
V
S
K
L
F
-
N
H
P
N
I
V
P
Y
R
A
T
F
I
A
D
N
E
L
W
V
V
T
S
F
M
A
Y
G
S
A
K
D
L
I
C
T
H
F
M
D
--
G
M
N
E
L
A
I
A
Y
I
L
Q
G
V
L
K
A
L
D
Y
I
H
H
M
G
Y
V
H
R
S
V
K
A
S
H
I
L
I
S
V
D
----
G
----
K
V
Y
L
S
G
L
R
S
N
L
S
M
I
S
HGQRQR
V
V
H
D
--
F
P
--
K
Y
S
V
K
V
L
P
W
L
S
P
E
-
V
L
Q
QNL----
Q
--
G
Y
D
A
K
S
D
I
Y
S
V
G
I
T
A
C
E
L
A
N
G
H
V
P
F
---
D
M
P
A
T
Q
-
M
--
L
L
E
K
L
V
P
C
L-------------
F
S
P
H
F
H
--
H
F
V
E
Q
C
L
Q
R
N
P
D
A
R
P
S
A
S
T
L
L
N
H
S
F
F
K
Q
I
K
R
R
-----
6
PsiBlast_PDB
58.68
33%
-41
- C1 -
-
5DFP
2
PAK1_HUMAN
A:
[65-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
--
E
G
Q
---
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
----
G
----
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
---------
E
--
Q
S
KR
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-------
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
LN
E
N
P
L
R
A
L
-
Y
--
L
I
A
-------
T
N
G
T
P
E
--
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-----------