@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_09_0450: (2018-03-08 )
MDSSSAAADAGGAAARSGLHVYSSAQANAAGSGTAALPNKALDHMKHMSRSKSDARRSGSKRTFDEATATDNVQLRRHDGTAVPNTAPNQVVEVVAPPPKKKKVTYALPHQNMEEGHFYVVLGEDIDVSTQRFKILSLLGEGTFGKVVESWDRKRKEYCAVKIVRNVPKYTRDAKIEIQFMEKVRQADPADRFPLMKIQRYFQNDSGHMCIVMPKYGPCLLDWIMKHGPFNHRHLAQIVFQTGVALDYFHSELHLMHTDLKPENILMETSDTTVDPATNRHLPPDPCRVRICDLGGCCDERHSRTAIVSTRHYRSPEVILGLGWMYSTDMWSMGCIIYELYTGKLLYDTHDNLEHLHLMEKTLGRLPSEWAARCGTEEARLLYNSAGQLRPCTDPKHLARIARARTVRDVIRDDLLCDLIYGLLHYDRQKRLNARQMTTHPYVLKYYPEARQAPSYPDNRAMLRPPPIM
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150-...-.-...160.......---170.......180......--.190.......-----200.-----.---.....210.......220....--.--.--.230...-----...---.240.......250.......260.....-----..270--------------..--.------------.-----------...-----.----280---...------..--------..---.290.......300.-------......310.......320........330.......340.......350-----.------..------.....360.......370.......----380..---.....--390.-------------------.....---.400.---.--....------.410...---------....420.......430.......440.......450.......460.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDSSSAAADAG
G
A
A
A
RS
G
L
H
V
Y
SSAQANAAGSGTAAL
P
N
K
A
L
D
H
M
K
H
M
S
RSK
S
D
A
RRSGSKRTFDEATATD
N
V
Q
L
RRHDGTAVPNTAPN
Q
V
V
E
V
VAPPPKK
K
K
V
T
Y
ALPHQNMEEG
H
F
Y
V
V
LGEDIDV
S
T
Q
R
F
K
I
L
S
L
LGEG
T
F
G
K
V
V
E
S
W
D
-
R
K
R
-
K
-
E
Y
C
A
V
K
I
V
RNVPK---YTRD
A
K
I
E
I
Q
F
M
E
K
V
RQAD--PADRF
P
L
M
K
I
Q
-----
R
Y
F
Q-----N---DSG
H
M
C
I
VMPKY
G
P
C
L
L
D
W
I
M
K--H--G--PF
N
H
R
H
L
-----
A
Q
I
---
V
F
Q
TG
V
A
L
D
Y
F
H
S
E
L
H
L
M
HTDLKPE
N
I
L
M
-----ETSD---------------TT--V------------D-----------PAT-----N----RH----LPP------DP--------
C
R
---
V
R
I
CDLGGCCDERHS-------
R
T
A
I
V
STRHYRSP
E
V
I
L
G
-
L
G
W
M
YSTDMWSM
G
C
I
I
Y
ELYT
G
K
L
L
YDTHD------
N
------
L
E
------
H
L
H
L
M
E
K
T
L
G
RL
P
S
E
W
A
A
RCG
T
E
E
A
----
R
L
L
YN---SAGQL--RPCT-------------------
D
P
K
H
L
---
A
R
I
A
R
---
A
--
R
T
V
R
------
D
V
I
R
D
D
L
---------
L
C
D
L
I
Y
G
L
L
H
Y
D
R
Q
KRL
N
A
R
QMTTH
P
Y
V
L
K
YYPEARQAPSYPDNRAMLRPPPIM
1
PsiBlast_PDB
85.03
34%
-39
- C1 -
-
2WU6
7
CLK3_HUMAN
A:
[37-377]
-----------------------------------------------------------------------------------------------------------------
K
E
G
H
L
V
C
R
I
G
---
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
Q
V
A
L
K
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
--
K
E
N
K
F
L
C
V
L
M
S
-----
D
W
F
------
N
---
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
--
N
--
N
FQ
P
Y
P
L
P
H
V
-----
R
H
M
---
A
Y
Q
L
C
H
A
L
R
F
L
H
-
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
-----
V
N
S
E
-------------------
F
------------
E
-----------
T
L
Y
-----
N
----
E
H
----
K
S
C
------
E
E
K
S
V
KN---
T
S
---
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
-------
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
------
N
------
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
--
T
R
K
Q
----
K
Y
F
Y
K
---
G
G
L
V
W
D
-
E
N
S
S
-------------------
D
G
R
Y
V
K
E
N
C
K
P
L
K
---
S
--
Y
M
L
Q
------
D
S
L
E
H
V
Q
---------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
------------------
2
PsiBlast_PDB
84.48
34%
-41
- C1 -
-
2WU7
1
CLK3_HUMAN
A:
[37-377]
-----------------------------------------------------------------------------------------------------------------
K
E
G
H
L
V
C
R
I
G
---
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
Q
V
A
L
K
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
--
K
E
N
K
F
L
C
V
L
M
S
-----
D
W
F
------
N
---
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
--
N
--
N
FQ
P
Y
P
L
P
H
V
-----
R
H
M
---
A
Y
Q
L
C
H
A
L
R
F
L
H
-
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
-----
V
N
S
E
-------------------
F
------------
E
-----------
T
L
Y
-----
N
----
E
H
----
K
S
C
------
E
E
K
S
V
KN---
T
S
---
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
-------
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
------
N
------
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
--
T
R
K
Q
----
K
Y
F
Y
K
---
G
G
L
V
W
D
-
E
N
S
S
-------------------
D
G
R
Y
V
K
E
N
C
K
P
L
K
---
S
--
Y
M
L
Q
------
D
S
L
E
H
V
Q
---------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
------------------
3
PsiBlast_PDB
84.08
34%
-35
- C1 -
-
3RAW
1
CLK3_HUMAN
A:
[37-377]
-----------------------------------------------------------------------------------------------------------------
K
E
G
H
L
V
C
R
I
G
---
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
Q
V
A
L
K
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
--
K
E
N
K
F
L
C
V
L
M
S
-----
D
W
F
------
N
---
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
--
N
--
N
FQ
P
Y
P
L
P
H
V
-----
R
H
M
---
A
Y
Q
L
C
H
A
L
R
F
L
H
-
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
-----
V
N
S
E
-------------------
F
------------
E
-----------
T
L
Y
-----
N
----
E
H
----
K
S
C
------
E
E
K
S
V
KN---
T
S
---
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
-------
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
------
N
------
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
--
T
R
K
Q
----
K
Y
F
Y
K
---
G
G
L
V
W
D
-
E
N
S
S
-------------------
D
G
R
Y
V
K
E
N
C
K
P
L
K
---
S
--
Y
M
L
Q
------
D
S
L
E
H
V
Q
---------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
------------------
4
PsiBlast_PDB
83.82
37%
-34
- C1 -
-
1Z57
1
CLK1_HUMAN
A:
[10-331]
------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
K
A
-
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
F
R
C
V
Q
M
L
-----
E
W
F
E
-----
H
----
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
--
N
--
G
FL
P
F
R
L
D
H
I
-----
R
K
M
---
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
-----
V
Q
S
D
---------------
Y
T
E
A
Y
------------
N
------------------------
R
D
E
R
T
L
I
N
P
------
D
--------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
------
S
------
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
FHHD
R
L
D
W
D
EHS
S
A
G
R
Y
V
S
R
A
C
K
-------------------
P
L
K
E
F
---------------
M
L
S
------
Q
D
V
E
H
E
R
---------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
---------------------------
8
PsiBlast_PDB
83.60
34%
-32
- C1 -
-
2EU9
1
CLK3_HUMAN
A:
[5-345]
-----------------------------------------------------------------------------------------------------------------
K
E
G
H
L
V
C
R
I
G
---
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
Q
V
A
L
K
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
--
K
E
N
K
F
L
C
V
L
M
S
-----
D
W
F
------
N
---
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
--
N
--
N
FQ
P
Y
P
L
P
H
V
-----
R
H
M
---
A
Y
Q
L
C
H
A
L
R
F
L
H
-
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
-----
V
N
S
E
-------------------
F
------------
E
-----------
T
L
Y
-----
N
----
E
H
-----
S
C
------
E
E
K
S
V
KN---
T
S
---
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
-------
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
------
N
------
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
--
T
R
K
Q
----
K
Y
F
Y
K
---
G
G
L
V
W
D-
E
N
S
S
-------------------
D
G
R
Y
V
K
E
N
C
K
P
L
K
---
S
--
Y
M
L
Q
------
D
S
L
E
H
V
Q
---------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
------------------
6
PsiBlast_PDB
83.18
37%
-29
- C1 -
-
5J1W
6
CLK1_HUMAN
A:
[10-331]
------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
K
A
-
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
F
R
C
V
Q
M
L
-----
E
W
F
E
-----
H
----
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
--
N
--
G
FL
P
F
R
L
D
H
I
-----
R
K
M
---
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
-----
V
Q
S
D
---------------
Y
T
E
A
Y
------------
N
-----------
P
K
I
-----
K
----
R
D
E
R
T
L
I
N
P
------
D
--------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
------
S
------
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
FHHD
R
L
D
W
D
EHS
S
A
G
R
Y
V
S
R
A
C
K
-------------------
P
L
K
E
F
---------------
M
L
S
------
Q
D
V
E
H
E
R
---------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
---------------------------
5
PsiBlast_PDB
82.75
37%
-29
- C1 -
-
5J1V
2
CLK1_HUMAN
A:
[10-331]
------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
K
A
-
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
F
R
C
V
Q
M
L
-----
E
W
F
E
-----
H
----
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
--
N
--
G
FL
P
F
R
L
D
H
I
-----
R
K
M
---
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
-----
V
Q
S
D
---------------
Y
T
E
A
Y
------------
N
-----------
P
K
I
-----
K
----
R
D
E
R
T
L
I
N
P
------
D
--------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
------
S
------
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
FHHD
R
L
D
W
D
EHS
S
A
G
R
Y
V
S
R
A
C
K
-------------------
P
L
K
E
F
---------------
M
L
S
------
Q
D
V
E
H
E
R
---------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
---------------------------
9
PsiBlast_PDB
82.30
36%
-28
- C1 -
-
2VAG
1
CLK1_HUMAN
A:
[10-331]
------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
K
A
-
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
F
R
C
V
Q
M
L
-----
E
W
F
E
-----
H
----
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
--
N
--
G
FL
P
F
R
L
D
H
I
-----
R
K
M
---
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
-----
V
Q
S
D
---------------
Y
T
E
A
Y
------------
N
-------------------
K
----
R
D
E
R
T
L
I
N
P
------
D
--------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
------
S
------
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
FHHD
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
-------------------
P
L
K
E
F
---------------
M
L
S
------
Q
D
V
E
H
E
R
---------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
---------------------------
10
PsiBlast_PDB
78.88
34%
-25
- C1 -
-
3NR9
1
CLK2_HUMAN
A:
[20-356]
------------------------------------------------------------------------------------------------------------------
E
G
H
L
I
Y
H
V
G
---
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
R
R
-
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
---
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
--
P
D
N
K
N
L
C
V
Q
M
F
-----
D
W
F
------
D
---
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
--
N
--
N
YL
P
Y
P
I
H
Q
V
-----
R
H
M
---
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
-----
V
N
S
D
---------------
Y
E
--
L
------------
T
-------------------------------
D
E
------
R
S
--------
V
K
ST
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
-------
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
------
N
------
R
E
------
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
--
T
R
K
Q
----
K
Y
F
Y
R
---
G
R
L
D
W
--
D
E
N
T
-------------------
S
A
G
R
Y
---
V
R
-
E
N
---
C
--
K
P
L
R
------
R
Y
L
T
S
E
A
E
E
H
H
Q
----
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
---------------------
43
HHSearch
76.30
35%
-27
- C1 -
-
1Z57
1
CLK1_HUMAN
A:
[13-335]
---------------------------------------------------------------------------------------------------------------------------------
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
-
G
-
R
H
V
A
V
K
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
F
R
C
V
Q
M
L
-----
E
W
F
E
-----
H
----
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
--
N
--
G
FL
P
F
R
L
D
H
I
-----
R
K
M
---
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
-----
V
Q
S
D
---------------
Y
T
--
E
------------
A
Y
N------------------R---
D
E
----
R
T
L
------
I
N
--------
P
D
---
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
------
S
------
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
----
F
H
H
D
R
---
L
D
W
D
E
--
H
S
S
A
-------------------
G
R
-
Y
V
---
S
R
A
C
K
PLK
E
--
F
M
L
S
------
Q
D
V
E
H
E
R
---------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------------
20
PsiBlast_PDB
75.81
26%
0
- C- -
-
3BEG
-
A:
[12--3]
----------------------------------------------------------------------------------------------------------------------
L
V
K
I
G
---
D
L
F
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
-
I
Q
G
-
K
-
K
F
V
A
M
K
V
V
K
S
A
E
H
---
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
N
S
D
--
P
N
D
P
N
R
E
M
V
V
Q
L
L
D
D
F
K
I
S
G
-----
V
---
N
G
T
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
--
S
-------
N
Y
Q
G
L
P
L
P
C
V
K
K
I
---
I
Q
Q
V
L
Q
G
L
D
Y
L
H
T
K
C
R
I
I
H
T
D
I
K
P
E
N
I
L
L
-----
S
V
N
E
Q
Y
I
R
R
L
A
A
EA------------------------------------------
A
----
G
N
----
F
L
V
------
N
P
LEPKNAEK
L
K
---
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
-------
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
-
S
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
------
G
------
E
E
YT
R
D
E
D
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
--
L
I
V
A
G
K
Y
S
----
K
E
F
F
T
---
K
K
G
D
L
--
K
H
I
T
K
L
-----------------
K
P
W
G
L
---
F
E
V
L
V
---
E
--
K
Y
E
W
------
S
Q
E
E
A
A
G
---------
F
T
D
F
L
L
P
M
L
E
L
I
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
--------------------------
13
PsiBlast_PDB
73.00
28%
-42
- C1 -
-
5MYV
2
SRPK2_HUMAN
A:
[27-387]
------------------------------------------------------------------------------------------------------------------------------
D
L
F
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
C
W
D
-
M
Q
G
-
K
-
R
F
V
A
M
K
V
V
K
S
A
Q
H
---
Y
T
E
T
A
L
D
E
I
K
L
L
K
C
V
R
E
S
D
--
P
S
D
P
N
K
D
M
V
V
Q
LI
D
D
F
K
I
S
G
-----
M
---
N
G
I
H
V
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
SN
Y
--
Q
--
G
L
P
V
R
C
V
-----
K
S
I
---
I
R
Q
V
L
Q
G
L
D
Y
L
H
S
K
C
K
I
I
H
T
D
I
K
P
E
N
I
L
M
-----
C
V
D
D
---------------
A
Y
--
V
R
R
M
A
A
E
A
T
E
W
QK-------------------------
L
L
----
V
N
P
LDPRNA
D
K
--------
I
R
---
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
-------
F
T
E
D
I
Q
T
R
Q
Y
R
S
I
E
V
L
I
G
-
A
G
Y
S
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
GEDYS
R
D
------
E
D
------
H
I
A
H
I
I
E
L
L
G
S
I
P
R
H
F
A
--
L
S
G
K
Y
S
----
R
E
F
F
N
---
R
R
G
E
L
--
R
-------------------------
H
I
---
T
K
L
-
K
---
P
--
W
S
L
F
------
D
V
L
V
E
K
Y
GWP
H
E
D
A
A
Q
F
T
D
F
L
I
P
M
L
E
M
V
P
E
K
R
A
S
A
G
E
C
L
R
H
P
W
L
--------------------------
12
PsiBlast_PDB
72.13
28%
-43
- C1 -
-
2X7G
7
SRPK2_HUMAN
A:
[27-387]
------------------------------------------------------------------------------------------------------------------------------
D
L
F
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
C
W
D
-
M
Q
G
-
K
-
R
F
V
A
M
K
V
V
K
S
A
Q
H
---
Y
T
E
T
A
L
D
E
I
K
L
L
K
C
V
R
E
S
D
--
P
S
D
P
N
K
D
M
V
V
Q
LI
D
D
F
K
I
S
G
-----
M
---
N
G
I
H
V
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
S
N
Y
--
Q
--
G
L
P
V
R
C
V
-----
K
S
I
---
I
R
Q
V
L
Q
G
L
D
Y
L
H
S
K
C
K
I
I
H
T
D
I
K
P
E
N
I
L
M
-----
C
V
D
D
---------------
A
Y
--
V
R
R
M
A
A
E-------------------------------
L
L
----
V
N
P
LDPRNA
D
K
--------
I
R
---
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
-------
F
T
E
D
I
Q
T
R
Q
Y
R
S
I
E
V
L
I
G
-
A
G
Y
S
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
G
EDYS
R
D
------
E
D
------
H
I
A
H
I
I
E
L
L
G
S
I
P
R
H
F
A
--
L
S
G
K
Y
S
----
R
E
F
F
N
---
R
R
G
E
L
--
R
-------------------------
H
I
---
T
K
L
-
K
---
P
--
W
S
L
F
------
D
V
L
V
E
K
Y
GWP
H
E
D
A
A
Q
F
T
D
F
L
I
P
M
L
E
M
V
P
E
K
R
A
S
A
G
E
C
L
R
H
P
W
L
--------------------------
21
HHSearch
71.86
29%
-39
* C1 *
-
4AZF
2
DYRK2_HUMAN
A:
[96-413]
---------------------------------------------------------------------------------------------------------------------------------
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
-
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
M
N
V
I
H
M
L
-----
E
N
F
T
-----
F
---
R
-
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
--
N
--
K
FQ
G
F
S
L
P
L
V
-----
R
K
F
---
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
-
R
I
I
H
C
D
L
K
P
E
N
I
L
L
-----
K
Q
Q
G
---------------
R
------------------------------------------------------------------
S
G
---
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
-------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
------
E
------
G
D
------
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
--
A
----
K
N
F
V
S
---
S
K
G
Y
P
--
R
Y
C
T
V
T
TLS
D
V
V
L
N
G
G
RSR
R
G
--
K
L
R
G
P
---
P
E
S
R
E
---
W
--
G
N
A
L
------
K
G
C
D
D
P
L
---------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-------------------------
19
PsiBlast_PDB
71.25
26%
-37
- C1 -
-
5MY8
24
?
A:
[9-381]
-----------------------------------------------------------------------------------------------------------------
K
G
G
Y
H
L
V
K
I
G
---
D
L
F
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
-
I
Q
G
-
K
-
K
F
V
A
M
K
V
V
K
S
A
E
H
---
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
N
S
D
--
P
N
D
P
N
R
E
M
V
V
Q
LL
D
D
F
K
I
S
G
-----
V
---
N
G
T
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
--
S
-------
N
Y
Q
G
L
P
L
P
C
V
K
K
I
---
I
Q
Q
V
L
Q
G
L
D
Y
L
H
T
K
C
R
I
I
H
T
D
I
K
P
E
N
I
L
L
-----
S
V
N
E
Q
Y
I
R
R
L
A
A
E
A
T
E
W
Q
R------------------------------------------------
F
L
V
------
N
P
LEPKNAEK
L
K
---
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
-------
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
-
S
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
------
G
------
E
E
YT
R
D
E
D
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
--
L
I
V
A
G
K
Y
S
----
K
E
F
F
T
---
K
K
G
D
L
--
K
H
I
T
K
L
-----------------
K
P
W
G
L
---
F
E
V
L
V
---
E
--
K
Y
E
W
------
S
Q
E
E
A
A
G
---------
F
T
D
F
L
L
P
M
L
E
L
I
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
--------------------------
27
HHSearch
70.86
29%
-29
- C1 -
-
5MY8
24
?
A:
[22-382]
---------------------------------------------------------------------------------------------------------------------------------
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
-
I
Q
G
-
K
-
K
F
V
A
M
K
V
V
K
S
A
E
H
---
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
N
S
D
PN
D
P
N
R
E
M
V
V
Q
L
L
-----
D
D
F
K
-----
I
S
G
V
N
G
T
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
--
S
NY
Q
--
G
L
P
L
P
C
V
-----
K
K
I
---
I
Q
Q
V
L
Q
G
L
D
Y
L
H
T
K
C
R
I
I
H
T
D
I
K
P
E
N
I
L
L
-----
S
V
N
E
---------------
Q
Y
--
I
------------
R
R
L
A
A
E
A
T
E
W
Q
R---FLVNP
L
----
E
P
----
K
N
A
------
E
K
--------
L
K
---
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
-------
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
-
S
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
------
G
EEYT
R
D
E
D
------
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
L
I
V
A
G
K
--
Y
S
----
K
E
F
F
T
---
K
K
G
D
L
--
K
H
I
T
-------------------
K
L
K
P
W
---
G
L
F
E
V
---
L
V
E
K
Y
E
W
------
S
Q
E
E
A
A
G
---------
F
T
D
F
L
L
P
M
L
E
L
I
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
N
-------------------------
22
HHSearch
70.33
28%
-37
- C1 -
-
5LXC
9
DYRK2_HUMAN
A:
[75-392]
---------------------------------------------------------------------------------------------------------------------------------
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
-
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
M
N
V
I
H
M
L
-----
E
N
F
T
-----
F
---
R
-
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
--
N
--
K
FQ
G
F
S
L
P
L
V
-----
R
K
F
---
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
-
R
I
I
H
C
D
L
K
P
E
N
I
L
L
-----
K
Q
Q
G
---------------
R
------------------------------------------------------------------
S
G
---
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
-------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
------
E
------
G
D
------
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
------
N
F
V
S
---
S
K
G
Y
P
--
R
Y
C
T
V
T
T
LSD
G
S
V
V
L
N
G
G
R
SRR
G
K
L
R
G
P
---
P
E
S
R
E
---
W
--
G
N
A
L
------
K
G
C
D
D
P
L
---------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-------------------------
18
PsiBlast_PDB
69.69
26%
-45
- C1 -
-
1WAK
5
SRPK1_HUMAN
A:
[22-395]
----------------------------------------------------------------------------------------------------------------
C
K
--
Y
H
L
V
K
I
G
---
D
L
F
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
-
I
Q
G
-
K
-
K
F
V
A
M
K
V
V
K
S
A
E
H
---
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
N
S
D
--
P
N
D
P
N
R
E
M
V
V
Q
LL
D
D
F
K
I
S
G
-----
V
---
N
G
T
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
--
S
-------
N
Y
Q
G
L
P
L
P
C
V
K
K
I
---
I
Q
Q
V
L
Q
G
L
D
Y
L
H
T
K
C
R
I
I
H
T
D
I
K
P
E
N
I
L
L
-----
S
V
N
E
Q
Y
I
R
R
L
A
A
E
A
------------------------------------
T
-----
A
----
G
N
----
F
L
V
------
N
P
LEPKNAEK
L
K
---
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
-------
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
-
S
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
------
G
------
E
E
YT
R
D
E
D
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
--
L
I
V
A
G
K
Y
S
----
K
E
F
F
T
---
K
K
G
D
L
--
K
H
I
T
K
L
-----------------
K
P
W
G
L
---
F
E
V
L
V
---
E
--
K
Y
E
W
------
S
Q
E
E
A
A
G
---------
F
T
D
F
L
L
P
M
L
E
L
I
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
--------------------------
11
PsiBlast_PDB
65.45
32%
-29
- C1 -
-
3LLT
1
?
A:
[37-359]
------------------------------------------------------------------------------------------------------------------------------------
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
Q
H
-
I
D
N
-
K
-
K
Y
Y
A
V
K
V
V
R
N
I
K
K
---
Y
T
R
S
A
K
I
E
A
D
I
L
K
K
I
Q
N
D
D
--
I
N
N
N
N
I
V
K
Y
H
G
-----
K
F
M
Y
-----
Y
---
D
--
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
--
N
--
N
---
Y
N
G
F
H
I
-----
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
R
-
K
M
S
L
T
H
T
D
L
K
P
E
N
I
L
L
DDPYF
E
K
S
L
---------------
I
T
--
V
------------
R
-----------
R
V
T
-----
D
G
K
K
I
Q
I
----
Y
R
T
------
K
S
--------
T
G
---
I
K
L
I
D
F
G
C
A
T
F
K
S
D
Y
-------
H
G
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
-
L
G
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
S
L
L
F
R
T
H
E
------
H
------
M
E
------
H
L
A
M
M
E
S
I
I
Q
P
I
P
K
N
M
L
Y
E
-
A
T
K
T
N
----
G
S
K
Y
V
---
N
K
D
E
L
--
K
L
A
W
--------------------
P
E
N
A
---
S
S
I
N
S
---
I
--
K
H
V
K
K
CLP
L
Y
K
I
I
K
H
E
L
---------
F
C
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
K
F
L
--------------------------
23
HHSearch
60.63
24%
-31
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[5-306]
---------------------------------------------------------------------------------------------------------------------------------
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
-
R
L
T
-
G
-
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
--------
I
I
A
I
K
-----
D
I
L
R
P
TVPY
G
---
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
--
S
--
Q
--
P
L
T
L
E
H
V
-----
R
Y
F
---
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
-
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
-----
N
E
N
C
-----------------------------------------------------------------------------------
E
---
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
PAEHQYF
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
------
Y
------
V
H
------
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
----
R
A
Y
I
Q
---
S
---
L
--
P
P
R
--------------------
Q
P
V
P
W
---
E
------------
T
V
------
Y
P
G
A
D
R
Q
---------
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
--------------------