@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_11_0250: (2018-03-08 )
MSTSEAEGSISGSGTLRGRACASGGAGKFDKAMKMYQKSMAIRRRLKSMASSTTRSLGDRDDDGFGGGALNEESAAAQTSLSPLRGPMLRSSTQITRVAPASSIASLASPQHSRVLPEMAFGVATASERTAMASQPAIALDAGSSVETRSSMAALMLYSHVPLPALNSFKRLSDPPDVERETAPSSSSPFSLAIPSRGRTKGGSGNRHKKVDASGGENDAVWRKRSPTCSAHLDFPYRFSAERQRTASRHNSGGTSEGFGVGIHKYAGQPSTSTVDSPLLSPMPSFHQMMGRSYDVPALNAIFRGFSNGVDRWQQDSRLLRSPPSPTHATMPAAPPTSVPSVSTSLQLSSSLVSKMSVPPPAAAVTRQIPTVSVSSSAETTAAADVHAMPAGNDAFSYLGPRLSAQAPSRKDRSNSYPADKARPEASGRSTVEGRDGVHASGSLPLVKTMASAPNLKPNEASVLPLGPPPLDESSAATTTTAQFYSTALLAKTFDGAQYLNDYILLNEIGSGSTGRVVLAFSTSMNKSVAIKIILKPKEKYRLQHRVSASPSTSVLGQHSSGGTFSGGRAATALATTTPEAMQNFKSSSSSARRRSKHRQTPSTPFTTAADKTRNLQREVEVMKDLNHPNIVRLYEVINDPKANSLFLVLQYVDNGAVAQLDSTGHIRAPLHPWTVLPIAAQISDGLVYLHEQHIVHRDIKPENILVNRDGHAFLADFGVAELMSAKAGQPTAATLTYQGTPLFMAPEIYAGVDDEDRDEDAEQAPGRCTRRRSSNDADESSNMTASPLCEERRDSRVIDPFALDVWALGVTFYTLLIGHVPFTSMLQISQTVEKGVNIPASLPEQWRTVLRRMMEPRQELRISSAELCHMLHAMLAEQEAAEVRAGGRSRKASLSTRSRSATLGNPRKASHQCCAEGRMARSASLAADAEEESMNLGSSSSSDESGTSGYSKGILGLSITSVGLNILRPTRIRKKQELSCRES
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.----......530.......540.......550.......560.......570.......-----580.......590.......600.......610.......620....-...630.......640---........650.......660.....-.--..670.......680.......690.......700.....--..--710-.-........720.......730........740.......750.......760.......770.......780.......790.......800.......810......-.820.--.------.---...---.---830-..-.-..-----------------------------.----.----.----.840.........850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSTSEAEGSISGSG
T
L
RGRACASGGAG
K
F
D
K
A
M
K
M
Y
Q
K
S
M
A
I
R
R
R
L
K
S
M
A
S
S
T
T
RSLGDRDDDGFGGGALNEESAAAQTSLSPLRGPMLRSST
Q
I
T
R
VA
P
A
S
S
I
A
S
LASP
Q
H
SRV
L
P
E
M
A
F
GVATASERTAMASQ
P
A
I
A
LDAGSSV
E
T
R
S
S
M
A
A
L
M
L
YSHVP
L
P
A
L
N
S
F
K
RLSDPPDVERETAPSSSS
P
F
S
L
AIPSRGRTKGGSGNRH
K
K
VDASGGENDAVWRKRSPTCSAHLDFPYRF
S
A
E
R
Q
R
T
ASRHNSGGTSEG
F
G
V
G
I
H
KYAGQPSTSTVDSPLLSP
M
P
S
F
H
Q
M
MGRSYD
V
P
A
L
N
A
I
F
R
G
F
SN
G
V
D
R
W
Q
Q
D
S
R
L
LRSPPSPTHATMPAAPPTSVPSV
S
T
S
L
Q
L
S
S
S
L
V
S
KMSVPP
P
A
A
A
V
TRQIP
T
V
SVSSSAETTAAA
D
V
H
AMPAGN
D
A
F
S
Y
LGPRLSAQAPSRKDRSNSYPADKARPEASGRSTVEGRDGVHASGSL
P
L
V
K
T
M
ASAPNLKPNEA
S
V
LPLGPPPLDESSAA
T
T
T
T
A
Q
F
Y
S
T
A
L
L
A
K
TFD
G
A
Q
Y
L
N
D
Y
I
L
L
NEIGSGST
G
R
V
V
L
A
F
ST----SMN
K
S
V
A
I
K
I
I
LKP
K
E
K
Y
R
L
Q
HRVSASPST
S
V
L
GQHSSGGTFSGG
R
A
A
T
A
L
ATT
T
P
-----
E
A
M
Q
N
F
KSSS
S
S
A
R
R
R
S
KHRQTPSTPFTTA
A
D
K
T
R
N
L
Q
R
E
V
E
V
M
K
DL-NH
P
N
I
V
R
L
Y
E
V
INDP----KA
N
S
L
F
L
V
L
Q
YVDNG
A
V
A
Q-LDSTGH-I--RAPLHPW
T
V
L
P
I
A
A
QISD
G
L
V
Y
L
HE
Q
H
I
V
HRDIKPE
N
I
L
V--NR--D---G-H
A
F
L
A
D
F
G
V
A
E
L
M
S
AKAGQP-
T
A
A
T
L
T
YQGTP
L
F
MA
P
E
IYAGVDDEDRD
E
D
A
EQAPGRCTRRRSSNDADESSNMTASP
L
C
E
E
RRDSRVI
D
P
F
A
L
D
V
W
A
L
G
V
T
F
Y
T
L
L
I-GHV
P
F
--
T
------
S
---
M
L
Q
---
I
---
S
---
Q
T
-
V
-
E
K-----------------------------G----V----N----IP--ASL
P
E
Q
W
R
T
V
L
R
R
M
ME
P
R
Q
E
LRI
S
S
A
E
L
C
H
M
L
H
A
M
L
A
E
Q
E
A
A
E
V
RAGGRSRKASLSTRSRSATLGNPR
K
A
S
H
Q
C
C
AEGRMARSASLAADA
E
E
E
SMNLGSSSSSDESGTSGYSKG
I
L
G
L
S
I
T
S
V
G
L
N
ILR
P
T
RIR
K
K
Q
ELSCRES
34
HHSearch
83.88
28%
0
- C- -
-
2WTK
1
STK11_HUMAN
F:
[3-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
K
Y
L
M
G
D
L
L
G
E
G
S
Y
G
K
V
K
E
V
L
D
S
----
E
T
L
C
R
R
A
V
K
I
L
K
K
K
K
L
R
R
------------------------------------------------------------------------
I
P
N
G
E
A
N
V
K
K
E
I
Q
L
L
R
R
L
-
R
H
K
N
V
I
Q
L
V
D
V
L
Y
N
---------
M
Y
M
V
M
E
Y
C
V
C
G
M
Q
E
M
-
L
D
S
V
P
-----
E
K
R
F
P
V
C
Q
A
H
G
Y
F
C
Q
L
I
D
G
L
E
Y
L
H
S
Q
G
I
V
H
K
D
I
K
P
G
N
L
L
L
--
T
T
--
G
---
G
-
T
L
K
I
S
A
L
G
V
A
E
A
L
H
P
F
A
A
---
D
D
T
C
R
T
S
Q
G
S
P
A
F
Q
P
P
E
I
A
N
G
L
D
T
-------------------------------------------
F
S
G
F
K
V
D
I
W
S
A
G
V
T
L
Y
N
I
T
T
-
G
L
Y
P
F
--
E
------
G
----------K
L
-
F
---
E
N
I
G
-
K
G
---------------------------------------
A
----
I
P
--
G
-----
L
S
D
L
L
K
G
M
L
E
Y
E
P
A
K
R
F
S
I
R
Q
I
R
Q
--
H
S
W
F
R
K
K
H
P
-------------------------------------------------------------------------------------------------------
37
HHSearch
78.88
24%
-82
- C1 -
-
3CBL
3
A:
[113-374]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
----
A
D
N
T
L
V
A
V
K
S
C
R
E
T
L
P
---------------------------------------------------------------------------
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
------
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
-
F
L
R
T
E
-----
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
--
T
E
--
K
---
N
-
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
--
Y
-
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
---------------------------------------------
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
--
P
------
N
---
L
S
N
Q
Q
-
T
---
R
---
E
F
-
V
-
E
K
-----------------------------
G
G
R
--
L
----
P
----
C
P
--
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
-----------------------------------------------------------------------------------------------------------
43
HHSearch
78.72
29%
-113
- C1 -
-
5K00
1
MELK_HUMAN
A:
[5-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
----
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
---------------------------------------------------------------------------
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
------
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
------
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
--
D
E
--
Y
---
H
-
K
L
K
L
I
D
F
G
L
C
A
K
P
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
--------------------------------------------
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
--
D
------
D
---
D
N
V
M
A
L
Y
---
K
---
K
I
-
M
-
R
G
-----------------------------
K
----
Y
----
D
----
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
--
H
P
W
I
M
-----------------------------------------------------------------------------------------------------------
36
HHSearch
76.89
24%
-81
- C1 -
-
3BKB
7
A:
[113-374]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
----
A
D
N
T
L
V
A
V
K
S
C
R
E
T
L
P
---------------------------------------------------------------------------
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
------
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
-
F
L
R
T
E
-----
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
--
T
E
--
K
---
N
-
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
--
Y
-
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
---------------------------------------------
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
--
P
------
N
---
L
S
N
Q
Q
-
T
---
R
---
E
F
-
V
-
E
K
-----------------------------
G
G
R
--
L
----
P
----
C
P
--
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
-----------------------------------------------------------------------------------------------------------
32
HHSearch
76.38
27%
-98
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
----
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
----------------------------------------------------------------------------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
-------
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
--
T
H
--
D
---
G
-
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
-----
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
P
---------------------------------------------
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
-
G
E
P
P
Y
--
F
------
N
---
E
P
P
---
L
K
A
-
M
---
K
M
-
I
-
R
D
-----------------------------
N
LPPR
L
----
K
----
N
L
--
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
--
H
P
F
L
A
K
----------------------------------------------------------------------------------------------------------
24
HHSearch
75.19
29%
-42
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[54-343]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
----
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
--------------------------------------------------------------------------------
R
F
K
N
R
E
L
Q
I
M
R
K
L
-
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
GEKK
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
-
A
R
H
Y
S
R
-
A
--
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
--
D
P
--
D
T--
A
-
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
------
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
--------------------------------------------
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-
G
Q
P
I
F
--
P
------
G
---
D
S
G
---
V
D
Q
L
V
---
E
I
-
I
-
K
V
LGTPT
R
E
Q
I
R
E
M
NPNYTEFKFPQIKAHP
W
T
----
K
----
V
----
F
R
--
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
--
H
S
F
F
D
E
L
---------------------------------------------------------------------------------------------------------
23
HHSearch
73.45
24%
-101
- C1 -
-
4G3F
1
A:
[56-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
H
W
M
T
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
----
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
---------------------------------------------------------------------------------
F
R
V
E
E
L
V
A
C
A
G
L
-
S
S
P
R
I
V
P
L
Y
G
A
V
R
E
------
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
-
L
I
K
Q
M
------
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
--
S
S
--
D
---
G
S
R
A
A
L
C
D
F
G
H
A
L
C
L
------------
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
M
G
K
P
---------------------------------------------
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
--
T
------
Q
---
Y
F
R
---
G
PL-
C
L
--
K
I
-
A
-
S
E
PPP--------------------------
I
----
R
----
E
----
I
P
--
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
V
G
K
A
L
Q
E
V
---------------------------------------------------------------------------------------------------------
38
HHSearch
72.38
25%
-62
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[92-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
----
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
L
S
------------------------------------
P
-----
E
---------------------------
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
------
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
K
------
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
D
--
N
---
M
-
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
------
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
---------------------------------------
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
--
W
------
H
---
R
R
Q
---
I
LM-
L
---
R
M
-
I
M
E
G
-----------------------------
Q
----
Y
----
Q
FSSP
E
W
--
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
--
H
P
F
F
------------------------------------------------------------------------------------------------------------
25
HHSearch
71.24
25%
-82
- C1 -
-
4IDV
1
M3K14_HUMAN
A:
[73-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
----
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
---------------------------------------------------------------------------------
F
R
A
E
E
L
M
A
C
A
G
L
-
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
------
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
-
L
V
K
E
Q
------
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
--
S
S
--
D
---
G
S
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
P
D
G
L
G
K
S
L
L
T
G
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
L
G
R
S
---------------------------------------------
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
--
T
------
Q
---
F
F
R
---
G
---
P
L
C
L
K
I
-
A
-
S
E
PPP--------------------------
V
----
R
----
E
----
I
P
--
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
---------------------------------------------------------------------------------------------------------
39
HHSearch
70.76
26%
-84
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[23-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
----
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
-----------------------------------------------------------------------
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
------
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
-
E
I
V
K
R
A
D
A
--
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
S
--
K
ENS
A
-
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
-----
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
P
---------------------------------------------
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
C
L
P
F
--
Y
------
G
---
T
K
E
R
L
-
F
---
E
---
G
I
-
I
-
K
G
-----------------------------
K
----
Y
KMNP
R
----
Q
W
--
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
--
H
P
W
L
K
-----------------------------------------------------------------------------------------------------------
35
HHSearch
69.47
26%
-80
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[23-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
----
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
-----------------------------------------------------------------------
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
------
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
-
E
I
V
K
R
A
D
A
--
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
S
--
K
ENS
A
-
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
-----
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
P
---------------------------------------------
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
C
L
P
F
--
Y
------
G
---
T
K
E
R
L
-
F
---
E
---
G
I
-
I
-
K
G
-----------------------------
K
----
Y
K
M
N
P
R
----
Q
W
--
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
--
H
P
W
L
K
-----------------------------------------------------------------------------------------------------------
26
HHSearch
68.45
27%
-98
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-348]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
----
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
----------------------------------------------------------------------------
K
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
------
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
-
R
I
I
D
E
-----
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
VN
R
D
--
A
---
K
-
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
------
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
F
---------------------------------------------
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
-
G
L
S
P
F
--
L
------
G
---
D
N
D
---
A
E
T
L
N
---
N
I
-
L
-
A
C
-----------------------------
R
WDLE
D
----
E
----
E
F
--
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
--
H
P
W
L
S
D
----------------------------------------------------------------------------------------------------------
42
HHSearch
67.78
25%
-65
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[92-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
----
A
T
G
H
E
F
A
V
K
I
M
E
V
---
R
L
S
------------------------------------
P
--------------------------------
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
------
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
K
------
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
D
--
N
---
M
-
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
------
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
---------------------------------------
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
--
W
------
H
---
R
R
Q
---
I
LM-
L
---
R
M
-
I
M
E
G
-----------------------------
Q
----
Y
QF--
S
SP--
E
W
--
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
--
H
P
F
F
------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
65.44
30%
-95
- C1 -
-
5UY6
1
KKCC2_HUMAN
A:
[77-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
I
A
I
L
K
K
L
-
D
H
P
N
V
V
K
L
V
E
V
L
D
D
P
----
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
M
E
-
V
P
T
L
-------
K
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
--
G
E
--
D
---
G
-
H
I
K
I
A
D
F
G
V
S
N
E
F
K
G
S
-----
D
A
L
L
S
N
T
V
G
T
P
A
F
M
A
P
E
---------------------------------------
S
L
S
E
T
R
---
K
I
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
-
G
Q
C
P
F
--
M
------
D
ER
I
M
C
L
---
H
---
S
---
K
I
-
K
-
S
Q
-----------------------------
A
----
L
----
E
----
F
P
DQ
P
D
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
V
V
P
E
I
--------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
65.44
30%
-86
- C1 -
-
2ZV2
1
KKCC2_HUMAN
A:
[85-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
I
A
I
L
K
K
L
-
D
H
P
N
V
V
K
L
V
E
V
L
D
D
P
----
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
M
E
-
V
P
T
L
-------
K
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
--
G
E
--
D
---
G
-
H
I
K
I
A
D
F
G
V
S
N
E
F
K
G
S
-----
D
A
L
L
S
N
T
V
G
T
P
A
F
M
A
P
E
---------------------------------------
S
L
S
E
T
R
---
K
I
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
-
G
Q
C
P
F
--
M
------
D
ER
I
M
C
L
---
H
---
S
---
K
I
-
K
-
S
Q
-----------------------------
A
----
L
----
E
----
F
P
DQ
P
D
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
V
V
P
E
I
--------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
64.68
30%
-90
- C1 -
-
5UYJ
1
KKCC2_HUMAN
A:
[77-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
I
A
I
L
K
K
L
-
D
H
P
N
V
V
K
L
V
E
V
L
D
D
P
----
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
M
E
-
V
P
T
L
-------
K
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
--
G
E
--
D
---
G
-
H
I
K
I
A
D
F
G
V
S
N
E
F
K
G
S
-----
D
A
L
L
S
N
T
V
G
T
P
A
F
M
A
P
E
---------------------------------------
S
L
S
E
T
R
---
K
I
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
-
G
Q
C
P
F
--
M
------
D
ER
I
M
C
L
---
H
---
S
---
K
I
-
K
-
S
Q
-----------------------------
A
----
L
----
E
----
F
P
DQ
P
D
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
V
V
P
E
I
--------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
64.62
28%
-82
- C- -
-
3FE3
-
MARK3_HUMAN
A:
[98-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
L
F
R
E
V
R
I
M
K
I
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
----
K
--
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
-
M
--
K
E
K
----
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
--
D
---
M
-
N
I
K
I
A
D
F
G
F
S
N
E
F
T
V
-
G
G
K
L
-
D
A
----
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
---------------------
K
K
Y
D
G
P
E
-----------------------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
DG
Q
------
N
---
L
K
E
---
L
---
R
---
E
R
-
V
-
L
R
-----------------------------
G
K
---
Y
----
R
----
I
P
--
F
Y
M
S
T
D
C
E
N
L
L
K
R
F
L
---------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
63.69
21%
-94
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[20-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
----
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
T
-----------------------------------------------------------------------------
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
------
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
-
R
I
N
T
S
A
-----
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
--
Q
T
RR
S
---
S
-
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
------
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
D
V
---------------------------------------------
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
I
N
P
F
--
L
------
A
---
E
T
N
---
Q
Q
I
I
E
---
N
I
-
M
-
N
A
-----------------------------
E
YTFD
E
----
E
----
A
F
--
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
--
H
P
W
L
K
Q
----------------------------------------------------------------------------------------------------------
49
Fugue
62.49
21%
-2
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
----
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
Y
R
E
EVH
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
R
A
E
E
L
M
A
C
A
G
L
-
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
------
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
-
L
V
K
E
Q
G
------
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
--
S
S
--
D
---
G
S
H
A
A
L
C
D
F
G
H
A
-------------
V
C
L
Q
I
P
G
T
E
T
H
M
A
P
E
V
V
L
G
R
S
C
---------------------------------------------
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
--
T
QFFRGP
L
---
C
L
K
---
I
---
A
---
S
E
-
P
-
P
P
-----------------------------
V
----
R
----
E
----
I
P
--
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
----------------------------------------------------------------------------------------
21
HHSearch
61.03
22%
-21
* C1 *
-
2PSQ
-
B:
[80-366]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
GIDP
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
---------------------------------------------------------------------------
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
------
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
-
Y
L
R
A
R
R
-
P
PG
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
--
T
E
--
N
---
N
-
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
---
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
---------------------------------------------
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
--
P
------
G
---
I
P
V
EE-
L
---
F
---
K
L
-
L
-
K
E
-----------------------------
G
H
R
--
M
----
D
----
K
P
--
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------------------------------------------------------------