@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_11_0560: (2018-03-08 )
MSIAFVGVSAVPPLERQKQRLANMDPSVYAVFEECRYKSLLAICHLARIIDAAMRGLDESTQVPASQPCEDTSHHDCALRSAANADREEPVGRPIADPTISRGSNEDLPLFIPLMDDNSDVSFCSMLHVEAESSSNASGLGYLSENAAKERSKQSTDMKATSHAALGNRERDVALFPHLNGHWECGIFGGKRVYIDTGGLYLGRGATALVYEGWMVVTDAMDGSEVCLAKVPVAIKEVTYNAKDRRLHDLYELAVNLRLNMVHPGIVHSYYAGTYMPRLAGFRSAEKAMVYAHLVLARSVTGSVADVLKRSGPFPESEIKRCMTEILSALQCVHEDHNCVHNDVKPHNILIFDDSSAYYAEFKYQIIDLTDIAPATPIEDVLRDLAAERKQQQNIFSERGTVMYMSPESCLGLGTLTSNDVWSLGITAFHMATGTLPWRPLERQYPSMILNGYRRKFTLRSLVDMHVNDAFGASGSCYPTGTDNPLHADSDGKPRARFHASSAPGSRATGGASCTSQVFCDQYKGFGPILDMLDEVSVSSEFRSFLEQCLTENPVKRPTCRQLRSHPFVKDVTVASQH
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240..------.----....250.......260........270.......280.......290.......300.......310----.......320.......330......--.340.......350.......360.......370.......380....-----------.--------..390.......400.......410-----........420.......430.......440.-...-.-..450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550....---...560.......570......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
I
A
F
V
GVSAVP
P
L
E
R
Q
K
Q
R
LANMD
P
S
V
Y
A
V
F
E
E
C
R
Y
K
S
L
L
A
I
C
H
L
A
R
I
I
D
A
A
M
RGLDESTQVPASQPCEDTSH
H
D
C
A
L
R
SAANADREEPVGRPIADPTISRGSNEDL
P
L
F
I
P
LMDDNSDV
S
F
C
S
M
L
H
V
EAESSSNASGLGY
L
S
E
N
A
A
K
E
RSKQSTDMKATSHAALGNRER
D
V
A
L
FPHLNG
H
W
E
C
G
IFGG
K
R
V
Y
I
DTG
G
L
Y
LGRG
A
T
A
L
V
YE
G
W
M
V
V
T
DAMDGS
E
V
C
L
A
KVP
V
A
I
K
E
VTYNAKD------
R
----
R
L
H
D
L
Y
E
L
A
V
N
L
R
L
NM-VHP
G
I
V
H
S
YYAGTY
M
P
R
L
AGF
R
S
A
E
K
A
M
V
Y
A
H
L
V
L
A
R
SV
T
G
S
V
A
D
V
L
K
RSG----PF
P
E
S
E
I
K
R
C
M
T
E
I
L
S
A
L
Q
C
V
H
EDHN--CVHNDVKP
H
N
I
L
I
FDDSS
A
Y
Y
A
E
F
K
Y
Q
I
I
D
LTDIAPAT
P
I
E
D
V
L
R
D
L
A
-----------
A
--------
E
R
K
Q
Q
Q
N
I
F
SERG
T
V
M
Y
M
S
P
E
S
C
L
------
G
L
GTLTSNDV
W
S
L
G
I
T
A
F
HMATGTLPWR
P
L
E
R
-
Q
Y
P
-
S
-
M
I
L
N
G
Y
R
R
K
F
T
L
R
S
L
V
D
M
HVNDAFGASGSCYPTGTDNPLHADSDGKP
R
A
R
F
HASSAPGSRATGGA
S
C
T
S
Q
V
F
C
D
Q
YKG
F
G
P
I
L
D
M
L
D
EV
S
V
S
S
E
F
R
S
F
L
E
Q
C
L
TENPVK---R
P
T
C
R
Q
L
RSHPFV
K
D
V
TVASQH
33
HHSearch
84.61
24%
-135
- C1 -
-
5IG1
-
?
A:
[22-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
I
G
K
G
A
F
S
T
V
H
R
C
V
N
K
R
T
----
G
-------
E
V
C
A
V
K
V
I
A
L
K
S
L
R
------
S
----
S
E
I
N
K
I
K
R
E
I
G
I
C
S
S
L
-
Q
H
E
H
I
V
S
M
R
R
A
F
R
-----------
D
E
S
H
F
Y
L
V
F
E
Y
V
S
--
G
G
E
L
F
D
E
I
V
T
R
K
----
F
Y
N
E
K
D
A
S
A
C
M
H
Q
I
L
S
A
L
Q
H
C
H
S
K
-
N
--
I
I
H
R
D
L
K
P
E
N
L
L
L
A
S
K
D
P
----
N
A
P
V
K
I
T
D
F
G
L
A
V
I
M
E
Q
G
---------------------------------
P
T
Y
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
I
R
------
R
V
P
Y
D
T
A
V
D
V
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
E
E
D
H
-
Q
K
L
-
Y
-
A
Q
I
K
------------
N
---------------------------
C
-----------------------------
Q
Y
--
D
F
P
S
---
P
E
W
D
S
V
T
T
A
A
K
E
L
I
K
A
M
L
E
P
N
P
K
R
---
R
P
T
V
Q
E
L
L
Q
H
P
W
I
A
R
R
D
-----
34
HHSearch
82.43
24%
-127
- C1 -
-
5IG1
-
?
B:
[22-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
I
G
K
G
A
F
S
T
V
H
R
C
V
N
K
R
T
----
G
-------
E
V
C
A
V
K
V
I
A
L
K
S
L
R
------
S
----
S
E
I
N
K
I
K
R
E
I
G
I
C
S
S
L
-
Q
H
E
H
I
V
S
M
R
R
A
F
R
-----------
D
E
S
H
F
Y
L
V
F
E
Y
V
S
--
G
G
E
L
F
D
E
I
V
T
R
K
----
F
Y
N
E
K
D
A
S
A
C
M
H
Q
I
L
S
A
L
Q
H
C
H
S
K
-
N
--
I
I
H
R
D
L
K
P
E
N
L
L
L
A
S
K
D
P
----
N
A
P
V
K
I
T
D
F
G
L
A
V
I
M
E
Q
G
---------------------------------
P
T
Y
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
I
R
------
R
V
P
Y
D
T
A
V
D
V
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
E
E
D
H
-
Q
K
L
-
Y
-
A
Q
I
K
------------
N
---------------------------
C
-----------------------------
Q
Y
--
D
F
P
S
---
P
E
W
D
S
V
T
T
A
A
K
E
L
I
K
A
M
L
E
P
N
P
K
R
---
R
P
T
V
Q
E
L
L
Q
H
P
W
I
A
R
R
D
-----
43
HHSearch
76.39
22%
-99
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[16-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
----
G
-------
L
E
F
A
A
K
I
I
N
T
K
K
L
S
------
A
----
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
Q
H
P
N
I
V
R
L
H
D
S
I
Q
-----------
E
E
S
F
H
Y
L
V
F
D
L
V
T
--
G
G
E
L
F
E
D
I
V
A
R
E
----
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
-
G
--
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
A
K
----
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
N
D
S
---------------------------------
E
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
------
K
D
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
-
H
R
L
-
Y
A
Q
I
K
A
G
---------------------------------------------------------------------
A
Y
--
D
Y
P
S
---
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
---
R
I
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
E
-----
21
HHSearch
76.33
23%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[9-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
-----------
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
------
A
----
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
-----------
E
E
G
F
H
Y
L
V
F
D
L
V
T
--
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
-
G
--
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
----
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
--------------------------------
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
-
H
R
L
-
Y
----
Q
---------
Q
I
K
A
---------------------------
G
-----------------------------
A
Y
--
D
F
P
S
---
P
E
W
D
T
V
T
P
E
A
K
D
L
I
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M
L
T
I
N
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A
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---
R
I
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A
S
E
A
L
K
H
P
W
I
C
Q
R
S
-----
42
HHSearch
75.74
27%
-74
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[9-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
----
G
-------
E
L
A
A
I
K
V
I
K
L
E
P
G
E
------------
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
H
P
N
I
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A
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F
G
S
Y
L
-----------
R
R
D
K
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W
I
C
M
E
F
C
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--
G
G
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D
I
Y
H
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G
----
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
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H
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-
G
--
K
M
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I
K
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A
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I
L
L
T
D
N
G
H
-------
V
K
L
A
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F
G
V
S
A
Q
I
T
A
T
I
--------------------------------
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
ER---
K
G
G
Y
N
Q
L
C
D
L
W
A
V
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I
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A
I
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A
E
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P
M
F
D
L
H
P
-
M
R
A
-
L
-
F
L
------------
M
T
K
----------------------------------------------------
S
N
F
------
Q
P
P
K
L
--
K
D
K
M
K
W
S
N
S
F
H
H
F
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M
A
L
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K
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P
K
K
---
R
P
T
A
E
K
L
L
Q
H
P
F
V
T
Q
H
------
29
HHSearch
75.61
29%
-89
- C1 -
-
5IU2
1
M3K8_HUMAN
B:
[78-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
F
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G
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M
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-
R
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A
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----
P
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Y
L
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Y
I
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-----------------------
H
-
K
---------------------------------
Q
A
P
P
L
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I
A
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P
N
H
---
R
P
R
A
A
D
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L
K
H
E
A
L
N
--------
38
HHSearch
75.37
24%
-110
- C1 -
-
4NIF
-
KS6A1_HUMAN
A:
[13-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
T
I
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G
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S
E
C
K
R
C
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T
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A
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D
K
S
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D
------
P
---------
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-
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D
-----------
D
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--
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---
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--------------------------------
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L
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---
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S
L
G
I
L
L
Y
T
M
L
A
G
Y
T
P
F
A
N
G
P
S
-
D
T
P
-
E
-
E
I
L
T
R
---------
I
G
---------------------------
S
G
----------------------------------
K
F
T
L
S
G
G
N
W
N
T
V
S
E
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
---
R
L
T
A
K
Q
V
L
Q
H
P
W
V
T
Q
K
------
26
HHSearch
71.09
23%
-7
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[99-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
----
G
-------
H
E
F
A
V
K
I
M
E
V
T
A
E
R
LSPEQL
E
----
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
-----------
S
S
S
F
M
F
L
V
F
D
L
M
R
--
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
-
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
M
Q
-------
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
---------------------------------
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
-
I
L
M
-
L
-
R
------------
M
I
M
E
---------------------------
G
-----------------------------
Q
---
Y
Q
F
S
--
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
---
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
--------
31
HHSearch
69.02
24%
-21
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[99-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
----
G
-------
H
E
F
A
V
K
I
M
E
V
---
R
LSPEQL
E
----
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
-----------
S
S
S
F
M
F
L
V
F
D
L
M
R
--
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
-
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
M
Q
-------
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
---------------------------------
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
-
I
L
M
-
L
R
M
I
M
E
G
Q
------------------------------------------------------------------------
Y
Q
F
S
S
--
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
---
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
--------
23
HHSearch
66.19
25%
-24
- C1 -
-
5O2C
4
WNK3_HUMAN
A:
[30-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
E
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
----
W
-------
V
E
V
A
W
C
E
L
Q
D
R
K
L
T
------
K
----
A
E
Q
Q
R
F
K
E
E
A
E
M
L
K
G
L
-
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
-------
L
K
G
K
K
C
I
V
L
V
T
E
L
M
T
--
S
G
T
L
K
T
Y
L
K
R
F
K
----
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
-
T
PP
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
T
------
G
S
V
K
I
G
D
L
G
L
A
T
L
M
R
T
----------------------------------
S
F
A
K
S
V
I
G
T
P
E
F
M
A
P
E
M
Y
E
-------
E
H
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
Y
S
E
C
Q
N
-
A
A
Q
----
I
Y
R
K
V
------------------------------------
T
S
G
---------------------------------
I
K
P
A
--
S
-
F
N
K
V
T
D
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
---
R
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
------
40
HHSearch
64.95
22%
6
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[18-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-----------
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
------
S
SRRG
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
-----------
N
K
T
D
V
I
L
I
L
E
L
V
A
--
G
G
E
L
F
D
F
L
A
E
K
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
---
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---------------------------------
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
-
L
----
A
N
V
S
---------
A
---------------------------
V
-----------------------------
N
Y
E
F
E
D
E
-----
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
---
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
-----
24
HHSearch
63.82
20%
-23
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[29-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
-----------
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP---
G
----
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
-----------
S
D
G
M
L
Y
M
V
F
E
F
M
D
--
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
--
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
----
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
--------------------------------
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
-
R
L
F
-
E
-
G
I
I
K
G
K
------------------------------------------------------------------------
Y
K
M
N
P
--
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
---
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
-----
28
HHSearch
62.54
22%
1
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[16-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
----
G
-------
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
------
S
SRRG
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
-----------
N
K
T
D
V
I
L
I
L
E
L
V
A
--
G
G
E
L
F
D
F
L
A
E
K
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
---
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---------------------------------
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
-
L
-
A
--
N
-
V
S
---------
A
---------------------------
V
---------------------------------
N
Y
E
F
-
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
---
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
-----
37
HHSearch
62.03
22%
-37
- C1 -
-
4LQS
1
CBK1_YEAST
A:
[107-453]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
K
D
T
----
G
-------
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
K-----
K
-------------------
S
-
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
-----------
D
A
Q
Y
L
Y
L
I
M
E
F
L
P
--
G
G
D
L
M
T
M
L
I
R
W
Q
----
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
-
G
--
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
G
H
-------
I
K
L
S
D
F
G
L
S
T
G
F
H
K
T
H
D
S
N
Y
---------------NRQQ
I
Q
T
W
R
K
S
R
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
------
Y
Q
G
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
E
T
P
-
Q
E
T
-
Y
-------------
R
K
I
M
N
F
E
------------------------------------------------------
Q
----
T
L
Q
F
P
---
D
D
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
Q
R
LGR
H
G
G
A
D
E
I
K
S
H
P
F
F
R
G
V
D
-----
45
Fugue
61.80
18%
-59
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
-------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
-----------
Q
C
A
V
K
K
V
R
-----------------
L
E
V
F
R
A
E
E
L
M
A
C
A
G
L
-
T
S
P
R
I
V
P
--
L
Y
G
A
V
R
E
G
-----------
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
G
----
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
-
R
R
--
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
H
---------
A
A
L
C
D
F
G
H
A
V
C
L
-------------------------------------
Q
I
P
G
T
E
T
H
M
A
P
E
V
V
L
------
G
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
F
F
R
G
P
L
C
-
L
-
K
I
A
S
E
P
P
P
V
R
E
I
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
-----------------------------------------------------------------
44
HHSearch
61.31
22%
-35
- C1 -
-
4LQQ
1
CBK1_YEAST
A:
[107-453]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
K
D
T
----
G
-------
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
K-----
K
-------------------
S
-
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
-----------
D
A
Q
Y
L
Y
L
I
M
E
F
L
P
--
G
G
D
L
M
T
M
L
I
R
W
Q
----
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
-
G
--
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
G
H
-------
I
K
L
S
D
F
G
L
S
T
G
F
H
K
T
H
D
S
N
Y
---L
T
M
S
N
RQQ
I
Q
T
W
--------
R
K
S
R
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
------
Y
Q
G
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
E
T
P
-
Q
E
T
-
Y
-------
R
------
K
I
M
N
---------------------------
F
-------------------------------
E
Q
T
L
Q
F
P
---
D
D
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
Q
R
LGR
H
G
G
A
D
E
I
K
S
H
P
F
F
R
G
V
D
-----
25
HHSearch
61.14
20%
-24
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[29-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
-----------
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP---
G
----
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
-----------
S
D
G
M
L
Y
M
V
F
E
F
M
D
--
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
--
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
----
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
--------------------------------
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
-
R
L
F
-
E
-
G
I
I
K
G
K
------------------------------------------------------------------------
Y
K
M
N
P
--
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
---
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
-----
10
PsiBlast_PDB
59.60
26%
-85
- C1 -
-
4NUS
1
KS6A3_HUMAN
A:
[38-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
K
V
F
-----
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
------
R
-----
V
R
T
K
M
E
R
D
I
L
V
E
V
N
---
H
P
F
I
V
K
L
H
Y
A
---------
F
Q
T
E
G
K
L
----
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
----------
I
K
L
T
D
F
G
L
S
K
E
S
I
D
-----------------------------
H
E
K
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
------
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
-
K
E
T
M
T
-
M
I
L
K
----------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
58.14
26%
-100
- C1 -
-
5D9L
1
KS6A3_HUMAN
A:
[38-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
K
V
F
-----
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
------
R
-----
V
R
T
K
M
E
R
D
I
L
V
E
V
N
---
H
P
F
I
V
K
L
H
Y
A
---------
F
Q
T
E
G
K
L
----
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
----------
I
K
L
T
D
F
G
L
S
K
E
-----------------------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
------
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
-
K
E
T
M
T
-
M
I
L
K
----------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
57.42
26%
-108
- C1 -
-
5D9K
1
KS6A3_HUMAN
A:
[38-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
K
V
F
-----
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
------
R
-----
V
R
T
K
M
E
R
D
I
L
V
E
V
N
---
H
P
F
I
V
K
L
H
Y
A
---------
F
Q
T
E
G
K
L
----
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
----------
I
K
L
T
D
F
G
L
S
K
-----------------------------------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
------
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
-
K
E
T
M
T
-
M
I
L
K
A
---------------------------------------------------------------------------------------------------------------------------------