@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_15_0180: (2018-03-08 )
MADSSKVTLSRASPERLVHHHRVRCAALEGETHAPYEVEAEPTQVDSSHRHYLHYGNAAHIGVHWHSSDAVHGGYSEPSAAGELTAESRETGAVNAAPAPTTSSSTSSPTSASTAARTRLSLSHLSPRTAGEGQPASLTHNPPAVHADPAARPAAPMASTGANGCGHPAVSASAEGRLNHVHATGEAGAPSSASSHSTGLPAPTAAPPKDASTTTAAKNHPLASATTHARTGFSNGRLPSHPEPAASTAAGTTRPPSHPQLPLSHPTTSSAAAAAAATFSSGAVAKEGGTNGAGASTSDGADPYARPAIALSVHLLDLYKMVNARYCAQRRLESPGPKYNSGYDDKDGHYLFLPGEVIFQRYIAQEVLGKGSFGTVIRGFDQKRSEAVAMKITRRGSSFRSQAKLELDILLRLNENPALNHLVVRLLKVFEWQGHLVLVFELLSFNLYQLIKCTRFNGVSLDLVRKFAYQLTHTLLQLELQKPHPIIHCDLKPENILLRNQNRSGIRLIDFGSACYTAKRFHRYIQSRFYRSPEVILFLDYGTPIDRWSLACVLVEMHTGVPLFDGRTEAAQLAKIEATLGPIPAGMVAGSPKANRFYYGNATSGFQLKEPIPERRTLESVIGVTTGGPRGRRLNTPGHDEKAYREFHDFISRFLRYQPEERMSCRDALQHPFLRPLYTSDLQQQKDREVAQPISAPQPPQKQQHTQCSQNSKPQPQSPKNINATTTKMLTSTERSRASALPPAE
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410...-..-.-.-420-.......430.......440.......450.......460.......470.....-.---.480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600......---------.--------610---------..--------.......620--.......630.......640....------------...650.......660.......670.......680.......690.......700.......710.......720.......730.......740...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MADS
S
K
V
T
LSRA
S
P
E
R
L
V
H
H
H
R
V
R
C
A
ALEGETHA
P
Y
E
VEAEPTQVDSSH
R
H
Y
L
HYG
N
A
A
H
I
G
V
H
WHSSDAVHGGYSEPSAAGELTAESRETGAVNAAPAPTTSSSTSSPTSASTA
A
R
T
R
L
S
LSHLSPRTAGEGQPASLTHNPPAVHADPAARPAAPMASTGANGCGHPAVSASAEGR
L
N
H
V
H
ATGEAGAPSSASSHSTGLPAPTAAPPKDASTTTAAKNHPLASATTHARTGFSNGRLPSHPEPAASTAAGTTRPPSHPQLPLSHPTTS
S
A
A
A
A
A
A
ATFSSG
A
V
AKEGGTNGAGASTSDGADPYAR
P
A
I
A
L
S
V
H
L
L
D
L
Y
K
M
V
N
A
R
Y
C
A
Q
R
RLESPGPKYNSGYDDKDG
H
Y
L
F
L
P
G
E
V
I
F
Q
R
Y
I
A
Q
E
V
LGKGS
F
G
T
V
I
RGF
D
Q
K
RSE
A
V
A
M
K
I
TRRGSSFRSQ
A
K
L
E
L
D
I
L
L
R
LNE-NP-
A
-
L
-
N
H
L
-
V
V
R
L
L
K
V
FEWQG
H
L
V
L
V
F
E
L
L
S
F
N
L
Y
Q
L
I
K
CTRFNGV
S
L
D
L
V
R
K
F
A
Y
Q
L
T
H
T
L
L
Q
-
L
---ELQKPH
P
I
I
H
C
DLKPE
N
I
L
L
RNQNRSG
I
R
L
I
DFG
S
A
C
Y
T
A
K
R
F
H
R
Y
I
Q
S
R
FYRSP
E
V
I
L
F
L
DYGTPI
D
R
W
S
L
A
C
V
L
V
EMHTGVPLFDGR
T
E
A
A
Q
L
A
K
I
E
A
TLGPIP
A
G
MVAGSPKAN
R
F
Y
YGNATSGFQL---------K--------E-----------PI--------P
E
R
R
T
L
E
S
V
I--GVTTGGPRGRRLNTPGH
D
E
K
A
Y
R
E
------------
F
H
D
F
I
S
R
F
L
RYQ
P
E
E
R
M
S
C
R
D
A
L
QHPFLR
P
L
Y
T
S
D
L
Q
Q
Q
K
D
R
E
V
AQPISAPQPPQ
K
Q
Q
H
TQCSQNSKPQPQSPKNINA
T
T
T
K
M
LTSTERSRASALPPAE
24
HHSearch
91.55
46%
-58
- C1 -
-
4YU2
2
DYR1A_HUMAN
A:
[10-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
-
H
D
-
T
-
E
M
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
---
A
T
-
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
KTKDGKRE
Y
-----------
K
P
--------
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
T
--------------------------------------------------------------------
23
HHSearch
89.13
46%
-51
- C1 -
-
4YLL
10
DYR1A_HUMAN
A:
[11-357]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
-
H
D
-
T
E--
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
---
A
T
-
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
KE------
Y
-----------
K
P
--------
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
---------------------------------------------------------------------
15
PsiBlast_PDB
85.55
45%
-48
- C1 -
-
4YLJ
3
DYR1A_HUMAN
A:
[28-356]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
-
E
-
M
-
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
A
TP
E
L
----
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
--------
K
-----------
T
K
DGKREYKP
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------
10
PsiBlast_PDB
85.47
45%
-47
- C1 -
-
2VX3
4
DYR1A_HUMAN
A:
[49-377]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
-
E
-
M
-
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
A
TP
E
L
----
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
--------
K
-----------
T
K
DGKREYKP
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------
14
PsiBlast_PDB
85.04
45%
-42
- C1 -
-
4MQ2
3
DYR1A_HUMAN
A:
[28-356]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
-
E
-
M
-
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
A
TP
E
L
----
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
--------
K
-----------
T
K
KREYKP--
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------
13
PsiBlast_PDB
84.81
45%
-48
- C1 -
-
4MQ1
3
DYR1A_HUMAN
A:
[28-356]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
-
E
-
M
-
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
A
TP
E
L
----
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
--------
K
-----------
T
K
DGKREYKP
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------
2
PsiBlast_PDB
84.47
45%
-43
- C1 -
-
3ANR
1
DYR1A_HUMAN
A:
[30-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
-
E
-
M
-
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
A
TP
E
L
----
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
--------
K
-----------
T
-EYKP----
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------
7
PsiBlast_PDB
84.38
45%
-44
- C1 -
-
5A4Q
1
DYR1A_HUMAN
A:
[30-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
-
E
-
M
-
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
A
TP
E
L
----
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
--------
K
-----------
T
-EYKP----
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------
18
PsiBlast_PDB
84.19
45%
-49
- C1 -
-
4YU2
2
DYR1A_HUMAN
A:
[28-356]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
-
E
-
M
-
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
A
TP
E
L
----
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
--------
K
-----------
T
K
DGKREYKP
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------
4
PsiBlast_PDB
84.14
45%
-42
- C1 -
-
5A3X
1
DYR1A_HUMAN
A:
[30-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
-
E
-
M
-
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
A
TP
E
L
----
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
--------
K
-----------
T
-EYKP----
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------
1
PsiBlast_PDB
84.06
45%
-42
- C1 -
-
3ANQ
1
DYR1A_HUMAN
A:
[30-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
-
E
-
M
-
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
A
TP
E
L
----
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
--------
K
-------------REYKP---
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------
19
PsiBlast_PDB
83.97
44%
-47
- C1 -
-
4AZE
1
DYR1A_HUMAN
A:
[49-377]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
-
E
-
M
-
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
A
TP
E
L
----
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
--------
K
-----------
T
K
DGKREYKP
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------
12
PsiBlast_PDB
83.74
45%
-40
- C1 -
-
5AIK
1
DYR1A_HUMAN
A:
[49-377]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
-
E
-
M
-
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
A
TP
E
L
----
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
--------
K
-----------
T
-KREYKP--
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------
6
PsiBlast_PDB
83.63
45%
-44
- C1 -
-
5A4L
1
DYR1A_HUMAN
A:
[30-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
-
E
-
M
-
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
A
TP
E
L
----
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
--------
K
-----------
T
-EYKP----
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------
3
PsiBlast_PDB
83.42
45%
-40
- C1 -
-
4NCT
1
DYR1A_HUMAN
A:
[30-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
-
E
-
M
-
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
A
TP
E
L
----
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
--------
K
-----------
T
-EYKP----
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------
16
PsiBlast_PDB
83.12
45%
-44
- C1 -
-
4YLK
13
DYR1A_HUMAN
A:
[28-356]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
-
E
-
M
-
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
A
TP
E
L
----
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
--------
K
-------------EYKP----
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------
17
PsiBlast_PDB
83.10
45%
-44
- C1 -
-
4YLL
10
DYR1A_HUMAN
A:
[28-356]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
-
E
---
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
A
TP
E
L
----
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
--------
K
-------------EYKP----
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------
11
PsiBlast_PDB
82.86
45%
-41
- C1 -
-
2WO6
1
DYR1A_HUMAN
A:
[49-377]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
-
E
-
M
-
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
A
TP
E
L
----
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
--------
K
-----------
T
-REYKP---
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------
5
PsiBlast_PDB
82.37
45%
-41
- C1 -
-
5A4E
1
DYR1A_HUMAN
A:
[30-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
-
E
-
M
-
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
A
TP
E
L
----
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
--------
K
-----------
T
-EYKP----
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------
8
PsiBlast_PDB
82.26
45%
-43
- C1 -
-
5A4T
1
DYR1A_HUMAN
A:
[30-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
-
E
-
M
-
K
Y
Y
-
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
-
L
A
TP
E
L
----
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
---------
K
--------
K
-----------
T
-EYKP----
P
G
T
R
K
L
H
N
I
L
--
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------
22
HHSearch
75.22
42%
-47
- C1 -
-
5LXC
9
DYRK2_HUMAN
A:
[60-392]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
-
Q
D
K
D
-
N
-
T
M
N
-
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
-
L
------
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
S
S
K
G
Y
P
R
Y
C
T
---------
V
--------
T
T
LSD
G
S
V
V
L
N
G
G
R
--------
S
R
R
G
K
L
R
G
P
P
---------
E
-
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
----------------------------------------------------------------------
21
HHSearch
71.71
42%
-42
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[85-413]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
-
Q
D
-
K
D
N
-
T
M
N
-
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
-
L
------
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
TLS
D
V
V
L
N
--------
G
-----------
G
R
--------
S
R
R
G
K
L
R
G
P
P
----------
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
----------------------------------------------------------------------
20
PsiBlast_PDB
70.53
41%
-21
- C1 -
-
5LXC
9
DYRK2_HUMAN
A:
[44-392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
-
Q
D
-
K
-
D
-
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
----
H
S
I
L
Q
C
L
---
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
---
S
S
K
G
Y
------------------------------------------
P
R
Y
C
T
V
T
T
L
S
D
G
S
V
V
L
N
G
G
R
S
R
R
G
K
L
R
G
P
P
E
S
--
R
E
W
G
N
A
LKGCD
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
----------------------------------------------------------------------