@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LINJ_36_0970: (2018-07-13 )
MPSSSSVTQPEPEATQGIELPACARKPRDPDFEAPASLHAQSKESNPLVLAPPPCPIICPEHERKMRRTSKSCIVPPPRQRQFMGDVVGLKVPDLVTGWKLPRKSSAHRCFLAAGGDVTVEPQPSSLAGANTKCPVRVPACAGSPTCGPRGENGVLIVSQDDRPAGLVNSRRRYSKESKPAVNGEDGVLLSEYEEDSADAAVRQTVARVRSKNCVLLIVLLVIIIVLAVAGGVGVGFVNKHYTTLTHRMYLESGERIVLNSSVMLLKNYHETLRADARHLLSFVRSSMIGRKPESIAVVQSTLYLPFFEAWSTWLFSSNVPSTHSIYVSMCGEPLANTVDCPFMALTIVCMPNVLQAACFYMHSDEVDRSRMIVNRIEVNESGIPRIGAFYKYVPLKVNYAHYQTNNDYGYFLDQDCAASLDGKVHTTLTIRRQIVVGDLVIICDASGFFERWFQRFEKGLQKKKDSHSVLFVNDGTVLAYDCGAPPRHRHVVSPCSMRLVPHKMGDCMAGKADMIDRIVDTFTVAMQRNKLMKRGGLSKDHVALTERVGDYIVVYQDFLSFRVGDGEPKTVFIAAYAVPLDTSLGRDGFVQISICVVIIIICMFLLGGVAMVAVNQMMRVVEVISQLSTHAATYDTKRMRSVLDRQKPGMLARVITSADIINCEFQHILTNLNAYRPFLPQSLLTKSSYSFSDEPLEPPSLWRSDVALGGSAADDVVVDEDGVPAKPLPRFHLKNTLEGSVSNPVENWRLLQRGFHRTKSTILVVSLSNVALDAGESVDAVNLFVQTVLNHAAIANGVVEVIEFQKIVVSFNSHFPVPRHQEKACLCALAIREEFRDRGCSISIGIASGYNYVGTTGTEQQKARVIMGESVVVAQSLTSLKNYLGCSILATDQVVFEALVTAVAVDVVQLYYEHNHQWVQYGVSEIIGNRYAVLSPDMQLVKSVFKLVRYRQAEEALEAVRRYVDAAAERRETPSWPVRRIHALVERQQLLIRSGYRRQRLQWQALEGDEIIMKHLSEENQSYNSKRQPRLMATVSTATVDSLATLSTHAKAAPCEFGFVSGDVLNAGSEAELARALVGEQSKLSMTRRQLAPIPSSCFSEDALFPVFTVKSSDGDEEERSPGSSRLSSQHNRVTDGNAEASGADSEEMRPVLLVEPQTLRSEERHDVRIGALLPPFTVTTSSPFLPAHDMEYPCTTAGISSMLSNSRRHSALDRQRHIAPTPLHDGTCHASTYATSGALGGVSGGKSSIGASLATTSAGNLGRTADSALKQSSENVAGLAKMHCSYKLPQRIVSVNGQVFHRTSQLVGRGSFGEVYVAISETGSLGAMKVFPLNDNNAPQLIREVETLSQMRHENIVGYDCCAVQDNFFFIICEYLAAGTLGSLIQKLGVIPERAARKYACDMLFGLGYLHQHSWLHCDIKPENILVTSDGTCKLADFGAASLGRSLTDAVSVRGTPRFSAPEAILGTWNQQADIYSFGITVAQMVTGVHPWHKYTEPDHLFVAHYAGEIRHSLQTGMPCAMQPDLPTNLQDKELESAIHRCCEFDPARRPTAEELVTLLS
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240..-....1250......1260......1270......1280......1290......1300......1310.....-.1320-.-......1330..-...---------.1340---...--.....1350-......1360....------..1370......1380..-....1390---.......1400-......1410.-..--...1420......1430.---.----.-.....1440......-.1450---......----...1460....-.-------.-1470.......1480......-1490......1500......1510......1520.....-.1530......1540......1550......1560..-----------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPSSSSVTQPEPEATQGIELPACARKPRDPDFEAP
A
S
LHAQSKESN
P
L
V
LAPPPC
P
I
IC
P
E
H
E
R
K
M
R
RTSKSCIVPP
P
R
Q
R
Q
F
M
G
D
VVGLKVP
D
L
VTGWKLPRKSSA
H
R
C
F
L
AAG
G
D
V
T
VEPQPSSLAGANTKC
P
V
RVPACAGSPTCGPRGEN
G
V
L
I
V
SQDDRP
A
G
L
V
N
S
R
R
RYSKESKPAVNGED
G
V
L
L
S
E
YEEDS
A
D
A
A
V
R
Q
T
V
A
R
V
RSKNC
V
L
L
I
V
L
L
V
I
I
I
V
L
A
VAGGV
G
V
G
F
V
N
K
H
Y
T
T
L
T
H
R
M
Y
LESG
E
R
I
V
LNS
S
V
M
L
L
K
N
Y
H
E
T
L
R
A
D
A
R
H
L
L
S
F
V
R
S
S
MIGRKP
E
S
I
A
V
V
Q
S
T
L
Y
L
P
F
F
E
A
W
S
T
W
L
FSSNVPST
H
S
I
Y
V
S
MCGEPLANTVD
C
P
F
M
A
L
T
I
V
C
M
P
N
V
L
Q
A
A
C
F
Y
MHSDEV
D
R
S
R
M
I
V
N
R
I
EVNESGIPRIG
A
F
Y
K
Y
V
P
L
K
V
N
Y
A
H
Y
QTNNDY
G
Y
F
LDQ
D
C
A
A
SLDG
K
V
H
T
T
L
T
I
R
R
Q
I
V
VG
D
L
V
I
I
CDA
S
G
F
F
E
R
W
F
Q
R
F
E
K
G
L
Q
KKKDSH
S
V
L
F
VND
G
T
V
L
A
Y
DCGAPPRH
R
H
VVSPCSMRLVPHKMGDCMAG
K
A
D
M
I
D
R
I
V
D
T
F
T
V
A
M
Q
R
N
K
L
M
K
RGGLS
K
D
H
V
A
L
T
E
RVG
D
Y
I
V
V
Y
Q
D
F
L
S
FRVGDGEP
K
T
V
F
I
A
A
Y
A
VPLDTSLGRD
G
F
V
Q
I
S
I
C
V
V
I
I
I
I
C
M
F
L
L
G
G
V
A
M
V
A
V
N
Q
M
M
R
V
V
E
V
I
S
Q
L
S
T
H
AAT
Y
D
T
K
R
M
R
S
V
L
DRQKP
G
M
L
A
R
V
ITSA
D
I
I
N
C
E
F
Q
H
I
L
T
NLNAYRPFL
P
Q
S
L
L
TKSSYSFSDEPLEP
P
S
L
W
R
S
D
VALGGSAAD
D
V
V
VDEDGVPAKPL
P
R
F
H
L
K
N
TLEGSVSN
P
V
E
N
W
R
L
L
Q
R
G
FHRTK
S
T
I
L
V
V
S
LS
N
V
ALDAGES
V
D
A
V
N
L
F
V
Q
T
V
L
N
H
A
A
I
A
N
G
V
V
E
V
I
E
F
Q
K
I
V
V
SFNSHFPVPRH
Q
E
K
A
C
L
C
A
L
A
I
R
E
E
F
R
DRGC
S
I
S
I
G
IASGYNYVGTTGT
E
Q
Q
K
A
R
V
I
MGE
S
V
V
V
A
Q
S
L
T
S
L
K
N
Y
LG
C
S
I
LA
T
D
Q
V
V
F
E
A
L
V
T
A
V
A
V
D
V
V
Q
L
Y
Y
EHN
H
Q
W
V
Q
Y
G
V
S
E
I
IGN
R
Y
A
VLSP
D
M
Q
L
V
K
S
V
F
K
L
V
R
Y
R
Q
A
E
E
A
L
E
A
V
R
R
Y
V
D
A
A
A
ERRETPSW
P
V
R
R
I
H
A
L
V
E
R
Q
Q
L
L
I
RSGYRRQ
R
L
Q
W
QALE
G
D
E
I
I
M
K
H
L
S
E
ENQSYNSKRQ
P
R
L
M
A
T
V
STA
T
V
D
S
L
A
T
LSTHAKAAPCEFGFVSGDVLNAG
S
E
A
E
L
A
R
A
L
VG
E
Q
S
K
L
S
M
T
R
R
QLAPI
P
S
S
CFSEDA
L
F
P
V
F
T
V
KSSDG
D
E
E
ERSPGSS
R
L
S
S
QHNRVTDGNAEASGA
D
S
E
EMR
P
V
L
L
VEPQTLRSEERH
D
V
R
I
G
A
LLPP
F
T
VTTSSPFLPAHDMEYPC
T
T
A
G
I
S
S
M
L
SNS
R
R
H
S
A
L
D
R
QRHIAPTPLHDGTCHASTYATSGALGGVS-GGKSSIG
A
S
L
ATTSAGNLG
R
T
A
D
S
A
L
K
QS
S
E
N
V
A
G
L
A
K
M
HCSYKL
P
Q
R
I
V
SVN
G
Q
V
F
H
R
T
S
Q
L
VGRGSF
G
E
V
Y
-
V
A
I
-S-E-TGSL
G
A
M
K
V
F
PL-NDN---------
N
A
--
P
---
Q
L
I
--
R
E
V
E
T
L
S
Q
M
-RHENIVG
Y
D
C
C
A
VQ------D
N
F
F
F
I
I
C
E
Y
L
AAG
T
L
G
S
-
L
I
Q
K
L-GV---I
P
E
R
A
A
R
K
Y
A
C
-
D
M
L
F
G
L
G
Y
L
HQ-H
S
--
W
L
H
C
DIKPE
N
I
L
V
TS--D---G----
T
-
C
K
L
A
DF
G
-
A
A
S
L
G
R
S
-
L
T
------
D
A
V
SVR----GTPRFSA
P
E
A
I
-
L
-------G-T-WNQQAD
I
Y
S
F
G
I
T
V
A
Q
M
V
T-GVHPWHKYTEPD
H
L
F
V
A
H
Y
A
G
E
I
R
H
S
L
QTGMPCAMQPDL-PTNL
Q
D
K
E
L
E
S
A
I
H
R
C
CEFDPARRP
T
A
E
E
L
V
T
--LLS-----------------------------------------------------------------
7
PsiBlast_PDB
67.34
29%
-35
- C1 -
-
5AX9
1
TNIK_HUMAN
A:
[23-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
G
N
G
T
Y
G
Q
V
Y
-
K
G
R
-
H
V
K
-
T
G
Q
L
A
A
I
K
V
M
D
V
-
T
G
D
---------
E
E
--
E
---
E
I
K
--
Q
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KNPPG
M
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
V
T
D
-
L
I
K
N
T
K
G
N
---
T
L
K
E
E
W
I
A
Y
I
C
R
E
I
L
R
G
L
S
H
L
H
Q
-
H
K
--
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
--
N
---
A
----
E
-
V
K
L
V
D
F
G
V
S
-------------------------
G
T
P
Y
W
M
A
P
E
V
I
-
A
CDENPD-
A
-
T
-
Y
D
F
K
S
D
L
W
S
L
G
I
T
A
I
E
M
A
E
-
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
--------------
I
P
R
N
P
A
P
R
L
-
K
S
K
K
W
S
K
K
F
Q
S
F
I
E
S
C
L
V
K
N
H
S
Q
R
P
A
T
E
Q
L
M
-----------------------------------------------------------------------
45
Fugue
66.24
27%
-23
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
-----
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
-
R
M
E
D
K
-
Q
-
T
G
F
Q
C
A
V
K
K
V
R
L
-
E
V
F
---------
R
A
-----------
E
E
L
M
A
C
A
G
L
-
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
------
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
-
L
V
K
E
Q
-
G
C
---
L
P
E
D
R
A
L
Y
Y
L
G
-
Q
A
L
E
G
L
E
Y
L
H
S
-
R
R
--
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
--
D
---
G
----
S
H
A
A
L
C
D
F
G
-
H
A
V
C
--------------
L
Q
I
P
----
G
T
E
T
H
M
A
P
E
V
V
-
L
-------
G
-
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
T
Q
F
F
R
G
P
L
C
L
K
I
A
S
E
P
P
------------
P
V
R
E
I
-
P
P
S
C
A
-
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
--
K
V
N
R
A
L
Q
Q
V
GGLKSPWR
G
E
Y
K
E
P
RHP------------------------------------------
12
PsiBlast_PDB
66.05
30%
-8
- C1 -
-
3P86
1
CTR1_ARATH
A:
[45-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
S
F
G
T
V
H
-
R
A
--
E
-
W
-
H
G
S
D
V
A
V
K
I
L
M
E
-
Q
D
F
---------
H
A
--
E
R
V
N
E
F
L
--
R
E
V
A
I
M
K
R
L
-
R
H
P
N
I
V
L
F
M
G
A
V
T
Q
------
P
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
-
L
L
H
K
S
-
G
A
R
E
Q
L
D
E
R
R
R
L
S
M
A
Y
-
D
V
A
K
G
M
N
Y
L
H
N
-
R
N
P
P
I
V
H
R
N
L
K
S
P
N
L
L
V
D
K
--
K
---
Y
----
T
-
V
K
V
C
D
F
----------------------------
G
T
P
E
W
M
A
P
E
V
L
-
R
-------
D
-
E
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
-
P
A
Q
V
V
A
A
-----------
V
G
F
K
C
K
-
R
L
E
I
-
P
R
N
L
-
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
--
L
L
------------------------------------------------------------------
29
HHSearch
65.59
22%
-93
- C1 -
-
5T18
1
A:
[9-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
-
Y
G
K
-
W
-
R
-
G
Q
Y
D
V
A
I
K
M
I
K
E
-
G
S
M
---------
S
E
--
D
---
E
F
I
--
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
------
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
-
Y
L
R
E
-------
F
Q
T
Q
Q
L
L
E
M
C
K
-
D
V
C
E
A
M
E
Y
L
E
S
-
K
Q
--
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
--
Q
---
G
----
V
-
V
K
V
S
D
F
G
-
L
S
R
Y
V
L
D
-
D
E
YT----
S
S
V
G
S
K
----
F
P
V
R
W
S
P
P
E
V
L
-
M
Y------
S
-
K
-
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
----------
I
A
Q
G
L
R
----
L
-
Y
-
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
--
N
I
------------------------------------------------------------------
11
PsiBlast_PDB
64.98
29%
-30
- C1 -
-
3SLS
2
MP2K1_HUMAN
A:
[17-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
-
G
A
G
N
G
G
V
V
F
K
V
S
H
-
K
-
P
-
S
G
L
V
M
A
R
K
L
I
H
L
-
E
I
K
---------
P
A
I
R
N
---
Q
I
I
--
R
E
L
Q
V
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
-
V
L
K
K
A
-
G
R
---
I
P
E
Q
I
L
G
K
V
S
I
-
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
--
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
--
R
---
G
----
E
-
I
K
L
C
D
F
G
-
V
S
G
---
Q
-
L
I
----------
F
V
----
G
T
R
S
Y
M
S
P
E
R
L
-
Q
-------
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
-
G
R
Y
P
I
G
------
A
I
F
------
E
L
L
D
Y
I
V
N
E
P
P
----
P
K
L
-
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
----------------------------------------------------------------------
8
PsiBlast_PDB
63.99
29%
-36
- C1 -
-
5CWZ
-
TNIK_HUMAN
A:
[23-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
G
N
G
--
G
Q
V
Y
-
K
G
R
-
H
V
K
-
T
G
Q
L
A
A
I
K
V
M
D
V
-
T
G
D
---------
E
E
--
E
---
E
I
K
--
Q
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KNPPG
M
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
V
T
D
-
L
I
K
N
T
K
G
N
---
T
L
K
E
E
W
I
A
Y
I
C
R
E
I
L
R
G
L
S
H
L
H
Q
-
H
K
--
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
--
N
---
A
----
E
-
V
K
L
V
D
F
G
V------------------
N
T
F
I
----
G
T
P
Y
W
M
A
P
E
V
I
-
A
CDENPD-
A
-
T
-
Y
D
F
K
S
D
L
W
S
L
G
I
T
A
I
E
M
A
E
-
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
--------------
I
P
R
N
P
A
P
R
L
-
K
S
K
K
W
S
K
K
F
Q
S
F
I
E
S
C
L
V
K
N
H
S
Q
R
P
A
T
E
Q
L
M
-----------------------------------------------------------------------
9
PsiBlast_PDB
63.15
29%
-36
- C1 -
-
5D7A
1
TNIK_HUMAN
A:
[23-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
G
N
G
T
Y
G
Q
V
Y
-
K
G
R
-
H
V
K
-
T
G
Q
L
A
A
I
K
V
M
D
V
-
T
G
D
---------
E
E
--
E
---
E
I
K
--
Q
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KNPPG
M
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
V
T
D
-
L
I
K
N
T
K
G
N
---
T
L
K
E
E
W
I
A
Y
I
C
R
E
I
L
R
G
L
S
H
L
H
Q
-
H
K
--
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
--
N
---
A
----
E
-
V
K
L
V
D
F
G
V------------------
N
T
F
I
----
G
T
P
Y
W
M
A
P
E
V
I
-
A
CDENPD-
A
-
T
-
Y
D
F
K
S
D
L
W
S
L
G
I
T
A
I
E
M
A
E
-
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
--------------
I
P
R
N
P
A
P
R
L
-
K
S
K
K
W
S
K
K
F
Q
S
F
I
E
S
C
L
V
K
N
H
S
Q
R
P
A
T
E
Q
L
M
-----------------------------------------------------------------------
21
HHSearch
63.04
30%
-41
- C1 -
-
4G3F
1
A:
[59-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
M
T
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
-
R
M
K
-
D
-
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
-
E
V
------------------
F
R
V
--
E
E
L
V
A
C
A
G
L
-
S
S
P
R
I
V
P
L
Y
G
A
V
R
E
------
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
-
L
I
K
Q
M
-
G
C
---
L
P
E
D
R
A
L
Y
Y
L
G
-
Q
A
L
E
G
L
E
Y
L
H
T
-
R
R
--
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
--
D
---
G
S---
R
-
A
A
L
C
D
F
G
-
H
A
L
C
L
-------------
D
Y
I
P
----
G
T
E
T
H
M
A
P
E
V
V
-
M
-------
G
K
P
-
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
T
Q
Y
F
R
G
P
L
C
L
K
I
---------
A
S
E
P
P
P
---
I
R
E
I
-
P
-
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
--
K
V
------------------------------------------------------------------
37
HHSearch
62.89
29%
-24
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[5-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
-
K
A
R
-
N
-
V
N
T
G
E
L
A
A
I
K
V
I
K
L
-
E
P
G
E--------
D
F
--
A
---
V
V
Q
--
Q
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
------
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
-
I
Y
H
V
T
-
G
P
---
L
S
E
L
Q
I
A
Y
V
S
R
-
E
T
L
Q
G
L
Y
Y
L
H
S
-
K
G
--
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
--
N
---
G
----
H
-
V
K
L
A
D
F
G
-
V
S
A
Q
I
T
A
-
T
I
A--------
A
F
I
----
G
T
P
Y
W
M
A
P
E
V
A
-
A
V
ERK---
G
-
G
-
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
-
L
Q
P
P
M
F
D
L
H
P
M
R
A
L
F
L
M
T
---------
K
S
N
F
Q
---
P
P
K
L
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
--
H
P
F
-----------------------------------------------------------------
6
PsiBlast_PDB
62.87
29%
-27
- C1 -
-
2X7F
-
TNIK_HUMAN
A:
[30-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
G
N
G
T
Y
G
Q
V
Y
-
K
G
R
-
H
V
K
-
T
G
Q
L
A
A
I
K
V
M
D
V
-
T
G
D
---------
E
E
--
E
---
E
I
K
--
Q
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
NG
M
--
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
V
T
D
-
L
I
K
N
T
K
G
N
---
T
L
K
E
E
W
I
A
Y
I
C
R
E
I
L
R
G
L
S
H
L
H
Q
-
H
K
--
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
--
N
---
A
----
E
-
V
K
L
V
D
F
G
V
S
A
------------------------
G
T
P
Y
W
M
A
P
E
V
I
-
A
-----------
Y
D
F
K
S
D
L
W
S
L
G
I
T
A
I
E
M
A
E
-
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
--------------
I
P
R
N
P
A
P
R
L
-
K
S
K
K
W
S
K
K
F
Q
S
F
I
E
S
C
L
V
K
N
H
S
Q
R
P
A
T
E
Q
L
M
-----------------------------------------------------------------------
13
PsiBlast_PDB
61.80
30%
4
- C1 -
-
3PPZ
1
CTR1_ARATH
A:
[45-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
S
F
G
T
V
H
-
R
A
--
E
-
W
-
H
G
S
D
V
A
V
K
I
L
M
E
--------------
A
--
E
R
V
N
E
F
L
--
R
E
V
A
I
M
K
R
L
-
R
H
P
N
I
V
L
F
M
G
A
V
T
Q
------
P
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
-
L
L
H
K
S
-
G
A
REQ
L
D
E
R
R
R
L
S
M
A
Y
-
D
V
A
K
G
M
N
Y
L
H
N
-
R
N
PP
I
V
H
R
D
L
K
S
P
N
L
L
V
D
K
--
K
---
Y
----
T
-
V
K
V
C
D
F
G
-
L
S
R
L
K
A
S
T
F
L
------
S
S
K
S
A
A
----
G
T
P
E
W
M
A
P
E
V
L
-
R
-------
D
-
E
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
-
P
A
Q
V
V
A
A
-----------
V
G
F
K
C
K
-
R
L
E
I
-
P
R
N
L
-
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
--
L
L
------------------------------------------------------------------
25
HHSearch
61.67
29%
-54
- C1 -
-
4IDV
1
M3K14_HUMAN
A:
[76-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
-
R
M
E
-
D
-
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
-
E
V
------------------
F
R
A
--
E
E
L
M
A
C
A
G
L
-
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
------
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
-
L
V
K
E
Q
-
G
C
---
L
P
E
D
R
A
L
Y
Y
L
G
-
Q
A
L
E
G
L
E
Y
L
H
S
-
R
R
--
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
--
D
---
G
S---
H
-
A
A
L
C
D
F
G
-
H
A
V
C
L
Q
P
-
D
G
LGKSLL
T
G
D
Y
I
P
----
G
T
E
T
H
M
A
P
E
V
V
-
L
-------
G
R
S
-
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
T
Q
F
F
R
G
P
L
C
L
K
I
---------
A
S
E
P
P
P
---
V
R
E
I
--
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
--
K
V
------------------------------------------------------------------
39
HHSearch
61.04
24%
-3
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[14-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
-
E
-
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-
R
R
T
KSSRRGV--
S
R
--
E
---
D
I
E
--
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
------
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
-
E
S
---
L
T
E
E
E
A
T
E
F
L
K
-
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
--
R
---
N
VP
K
P
R
-
I
K
I
I
D
F
G
-
L
A
H
K
I
D
F
-
G
N
------
E
F
K
N
I
F
----
G
T
P
E
F
V
A
P
E
I
V
-
N
Y------
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
-
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
-------
A
V
N
Y
E
----
F
E
D
E
Y
-
F
-
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
--
H
P
W
-----------------------------------------------------------------
32
HHSearch
59.09
21%
-64
- C1 -
-
4Y95
4
?
A:
[8-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
-
Y
G
K
-
W
-
R
-
G
Q
Y
D
V
A
I
K
M
I
K
E
-
G
S
M
---------
S
E
--
D
---
E
F
I
--
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
------
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
-
Y
L
R
E
M
R
H
R
---
F
Q
T
Q
Q
L
L
E
M
C
K
-
D
V
C
E
A
M
E
Y
L
E
S
-
K
Q
--
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
--
Q
---
G
----
V
-
V
K
V
S
D
F
G
-
M
T
R
F
V
L
D
-
D
E
YT----
S
S
T
G
T
K
----
F
P
V
K
W
A
S
P
E
V
L
-
M
Y------
S
-
K
-
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
----------
A
Q
G
L
R
----
L
P
R
-
P
-
H
L
A
S
E
R
V
Y
A
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
--
N
I
------------------------------------------------------------------
40
HHSearch
58.81
22%
-64
- C1 -
-
5U9D
6
A:
[13-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
-
Y
G
K
-
W
-
R
-
G
Q
Y
D
V
A
I
K
M
I
K
E
-
G
S
M
---------
S
E
--
D
---
E
F
I
--
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
------
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
-
Y
L
R
E
M
R
H
R
---
F
Q
T
Q
Q
L
L
E
M
C
K
-
D
V
C
E
A
M
E
Y
L
E
S
-
K
Q
--
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
--
Q
---
G
----
V
-
V
K
V
S
D
F
G
-
L
S
R
Y
V
L
D
-
D
E
YT----
S
S
V
G
S
K
----
F
P
V
R
W
S
P
P
E
V
L
-
M
Y------
S
-
K
-
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
----------
A
Q
G
L
R
----
L
Y
--
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
--
N
I
------------------------------------------------------------------
38
HHSearch
58.79
24%
1
* C1 *
-
4PF4
6
DAPK1_HUMAN
A:
[13-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
-
E
-
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-
R
R
T
KSSRRGV--
S
R
--
E
---
D
I
E
--
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
------
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
-
E
S
---
L
T
E
E
E
A
T
E
F
L
K
-
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
--
R
---
N
VP
K
P
R
-
I
K
I
I
D
F
G
-
L
A
H
K
I
D
F
-
G
N
------
E
F
K
N
I
F
----
G
T
P
E
F
V
A
P
E
I
V
-
N
Y------
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
-
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
---------
A
V
N
-
Y
-
E
F
E
D
E
Y
--
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
--
H
P
W
-----------------------------------------------------------------
31
HHSearch
58.66
24%
-6
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[12-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
-
E
-
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-
R
R
T
KSSRRGV--
S
R
--
E
---
D
I
E
--
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
------
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
-
E
S
---
L
T
E
E
E
A
T
E
F
L
K
-
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
--
R
---
N
VP
K
P
R
-
I
K
I
I
D
F
G
-
L
A
H
K
I
D
F
-
G
N
------
E
F
K
N
I
F
----
G
T
P
E
F
V
A
P
E
I
V
-
N
Y------
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
-
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
---------
S
A
V
N
-
Y
-
E
F
E
D
E
Y
--
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
--
H
P
W
-----------------------------------------------------------------
26
HHSearch
58.37
22%
-32
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[95-362]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
-
R
C
V
-
H
-
R
A
T
G
H
E
F
A
V
K
I
M
E
V
-
T
A
E
RLSPEQLEE
V
R
--
E
---
A
T
R
--
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
------
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
K
-
V
A
---
L
S
E
K
E
T
R
S
I
M
R
-
S
L
L
E
A
V
S
F
L
H
A
-
N
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
--
N
---
M
----
Q
-
I
R
L
S
D
F
G
-
F
S
C
H
L
E
P
-
G
E
------
K
L
R
E
L
C
----
G
T
P
G
Y
L
A
P
E
I
L
-
K
CSMDETH
P
-
G
-
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
---------
M
E
G
Q
Y
Q
---
F
S
S
P
-
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
--
H
P
F
-----------------------------------------------------------------
42
Fugue
57.36
19%
-27
- C1 -
-
1KOB
1
?
A:
[23-374]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
--
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
-
R
C
V
E
K
-
A
-
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
P
L
---------
D
K
--
Y
---
T
V
K
--
N
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
H
D
A
F
E
D
------
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
-
Y
K
---
M
S
E
A
E
V
I
N
Y
M
R
-
Q
A
C
E
G
L
K
H
M
H
E
-
H
S
--
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
KK
A
---
S
----
S
-
V
K
I
I
D
F
G
-
L
A
T
K
L
N
P
-
D
E
------
I
V
K
V
T
T
----
A
T
A
E
F
A
A
P
E
I
V
-
D
-------
R
-
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
-
G
L
S
P
F
A
G
E
D
----------
D
L
E
T
L
Q
N
V
K
R
C
D
W
E
F
D
E
D
A
F
-
S
S
V
--
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
HP
W
L
K
GDHSNLTSRIPSSRY
N
K
I
R
Q
K
I
K
E
K
Y
ADWPAPQPAIGRIANFSSLRKHRPQEYQ
I
Y
D
S
Y
F
DRKEA
33
HHSearch
56.67
23%
-27
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[5-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
-
R
C
M
-
K
-
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-
K
K
L
S
A
R
------
D
H
--
Q
---
K
L
E
--
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
------
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
-
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
--
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
--
K
SKG
A
----
A
-
V
K
L
A
D
F
G
-
L
A
I
E
V
Q
G
-
D
Q
Q-----
A
W
F
G
F
A
----
G
T
P
G
Y
L
S
P
E
V
L
-
R
K------
D
-
P
-
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
----------
K
A
G
A
Y
D
--
F
P
S
P
-
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
--
H
P
W
-----------------------------------------------------------------
19
PsiBlast_PDB
53.64
32%
2
- C1 -
-
4O27
1
STK24_HUMAN
B:
[14-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
-
K
G
I
D
N
-
R
-
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
---------
E
D
--
E
---
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
E
P
--
G
P
---
L
D
E
T
Q
I
A
T
I
L
R
-
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
--
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
--
H
---
G
----
E
-
V
K
L
A
D
F
G
-
V
A
G
---
Q
-
L
T
------
D
T
Q
I
K
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
-------
S
-
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
-
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
--------------
I
P
K
N
N
P
P
T
L
-
E
G
N
Y
S
-
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
-----------------------------------------------------------------------
18
PsiBlast_PDB
53.36
32%
3
- C1 -
-
3CKX
1
STK24_HUMAN
A:
[15-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
-
K
G
I
D
N
-
R
-
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
-----------
D
--
E
---
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
E
P
--
G
P
---
L
D
E
T
Q
I
A
T
I
L
R
-
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
--
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
--
H
---
G
----
E
-
V
K
L
A
D
F
G
-
V
A
G
---
Q
-
L
T
------
D
T
Q
I
K
R
NTFV
G
T
P
F
W
M
A
P
E
V
I
K
Q
-------
S
-
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
-
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
--------------
I
P
K
N
N
P
P
T
L
-
E
G
N
Y
S
-
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
-----------------------------------------------------------------------
17
PsiBlast_PDB
52.85
32%
6
- C1 -
-
4W8D
1
STK24_HUMAN
A:
[22-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
-
K
G
I
D
N
-
R
-
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
---------
E
D
--
E
---
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
E
P
--
G
P
---
L
D
E
T
Q
I
A
T
I
L
R
-
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
--
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
--
H
---
G
----
E
-
V
K
L
A
D
F
G
-
V
A
G
---
Q
-
L
T
------
D
T
Q
I
K
R
NTFV
G
T
P
F
W
M
A
P
E
V
I
K
Q
-------
S
-
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
-
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
--------------
I
P
K
N
N
P
P
T
L
-
E
G
N
Y
S
-
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
-----------------------------------------------------------------------
15
PsiBlast_PDB
50.67
32%
8
- C1 -
-
4W8E
1
STK24_HUMAN
A:
[22-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
-
K
G
I
D
N
-
R
-
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
---------
E
D
--
E
---
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
E
P
--
G
P
---
L
D
E
T
Q
I
A
T
I
L
R
-
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
--
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
--
H
---
G
----
E
-
V
K
L
A
D
F
G
-
V
A
G
---
Q
-
L
T
------
D
T
Q
I
K
R
NTFV
G
T
P
F
W
M
A
P
E
V
I
K
Q
-------
S
-
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
-
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
--------------
I
P
K
N
N
P
P
T
L
-
E
G
N
Y
S
-
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
-----------------------------------------------------------------------
16
PsiBlast_PDB
50.48
32%
4
- C1 -
-
4U8Z
1
STK24_HUMAN
A:
[22-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
-
K
G
I
D
N
-
R
-
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
---------
E
D
--
E
---
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
E
P
--
G
P
---
L
D
E
T
Q
I
A
T
I
L
R
-
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
--
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
--
H
---
G
----
E
-
V
K
L
A
D
F
G
-
V
A
G
---
Q
-
L
T
------
D
T
Q
I
K
R
NTFV
G
T
P
F
W
M
A
P
E
V
I
K
Q
-------
S
-
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
-
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
--------------
I
P
K
N
N
P
P
T
L
-
E
G
N
Y
S
-
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
-----------------------------------------------------------------------