@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0147: (2017-12-16 )
MKIKKWLGLAALATVAGLALAACGNSEKKADNATTIKIATVNRSGSEEKRWDKIQELVKKDGITLEFTEFTDYSQPNKATADGEVDLNAFQHYNFLNNWNKENGKDLVAIGDTYISPIRLYSGLNGSANKYTKVEDIPANGEIAVPNDATNESRALYLLQSAGLIKLDVSGTALATVANIKENPKNLKITELDASQTARSLSSVDAAVVNNTFVTEAKLDYKKALFKEQADENSKQWYNIIVAKKDWETSPKADAIKKVIAAYHTDDVKKVIEESSDGLDQPVW
Atome Classification :
(20 SA)
.........10........20........30........40........50......-.-.-60........70........80........90........100-...-....110.......120.......130.....-..-140.......150.......160.....-..---170--..-......180.......190.......200-........210.......-220-.-.-......230........240.....-.-.250.......260.......270.......-280..--------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
I
K
K
W
L
G
L
A
A
L
A
T
V
A
G
L
A
L
AACGNSEKKADN
A
T
T
I
K
I
A
T
VNRSGS
E
E
K
R
W
D
K
I
Q
E
L
-
V
-
K
-KDG
I
T
L
E
F
TEFTDYSQPNKATADGEV
D
L
N
A
F
Q
H
Y
N
F
L
NNWNKE-NG
K
-
D
L
V
A
IGDTY
I
S
P
I
R
L
YSGLNGSANKYTKVEDI-PA-NG
E
I
AVPNDATNE
S
R
A
L
Y
L
L
QSA
G
L
I
K
L
-DV---SG---
T
A
-
L
A
T
V
A
NIKENPKN
L
K
I
T
EL
D
A
S
Q
T
A
R
S
L
--
S
S
V
D
A
A
VVNN
T
F
VTEAK
L
-
D
-
Y
-
K
-
K
-
A
L
F
K
E
QAD-ENS
K
Q
W
Y
N
I
I
V
A
KKDW-E-TSP
K
A
D
A
I
K
K
V
I
A
A
Y
H
T
D
D
V
K
K
V
I
E
ESSDGL-DQPVW--------------
28
HHSearch
99.86
61%
0
- C- -
-
4Q5T
-
?
A:
[4--1]
------------------------------
N
D
K
N
T
L
T
V
G
V
M
T
M
T
D
S
D
K
E
R
W
D
K
I
E
E
L
-
L
-
K
-
K
E
N
I
K
L
K
F
K
E
F
T
D
Y
S
Q
P
N
K
A
L
K
N
G
E
I
D
I
N
S
F
Q
H
Y
N
F
L
N
N
W
N
K
E
-
N
K
G
-
D
L
V
T
V
A
E
T
Y
I
S
P
I
N
L
F
S
G
T
E
N
G
K
A
K
Y
S
S
A
K
E
I
--
P
N
G
G
Q
I
A
I
P
N
D
A
T
N
E
S
R
A
L
Y
V
L
Q
D
A
G
L
I
K
L
-
N
V
---
S
G
---
D
E
-
L
A
T
V
K
N
I
K
S
N
P
K
N
L
D
I
K
E
V
D
A
S
Q
T
A
R
N
L
--
A
S
V
D
A
A
V
V
N
N
S
Y
A
V
P
A
K
I
-
D
-
F
-
K
-
T
-
S
L
Y
K
E
K
V
N
-
E
G
S
K
Q
W
I
N
I
I
A
A
Q
K
N
W
K
K
S
K
K
A
--
A
A
I
K
K
L
I
K
A
Y
H
T
D
A
V
K
K
V
I
K
K
T
A
K
G
V
-
D
E
P
V
W
--------------
1
PsiBlast_PDB
98.45
65%
0
- C- -
-
4Q5T
-
?
A:
[19--1]
---------------------------------------------
S
D
K
E
R
W
D
K
I
E
E
L
-
L
-
K
-
K
E
N
I
K
L
K
F
K
E
F
T
D
Y
S
Q
P
N
K
A
L
K
N
G
E
I
D
I
N
S
F
Q
H
Y
N
F
L
N
N
W
N
K
E
-
N
K
G
-
D
L
V
T
V
A
E
T
Y
I
S
P
I
N
L
F
S
G
T
E
N
G
K
A
K
Y
S
S
A
K
E
I
-
P
N
-
G
G
Q
I
A
I
P
N
D
A
T
N
E
S
R
A
L
Y
V
L
Q
D
A
G
L
I
K
L
-
N
V
---
S
G
---
D
E
-
L
A
T
V
K
N
I
K
S
N
P
K
N
L
D
I
K
E
V
D
A
S
Q
T
A
R
N
L
--
A
S
V
D
A
A
V
V
N
N
S
Y
A
V
P
A
K
I
-
D
-
F
-
K
-
T
-
S
L
Y
K
E
K
V
N
-
E
G
S
K
Q
W
I
N
I
I
A
A
Q
K
N
W
-
K
-
K
S
K
K
A
A
A
I
K
K
L
I
K
A
Y
H
T
D
A
V
K
K
V
I
K
K
T
A
K
G
V
-
D
E
P
V
W
--------------
7
PsiBlast_PDB
74.74
32%
-89
- C5 -
-
1XS5
-
TPN32_TREPA
A:
[22-221]
------------------------------------------------------
K
E
E
-
V
-
K
-
K
Q
H
I
E
L
R
I
V
E
F
T
N
Y
V
A
L
N
E
A
V
M
R
G
D
I
L
M
N
F
F
Q
H
V
P
H
M
Q
Q
F
N
Q
E
-
H
N
G
-
D
L
V
S
V
G
N
V
H
V
E
P
L
A
L
Y
S
------
R
T
Y
R
H
V
S
D
F
-
P
A
-
G
A
V
I
A
I
P
N
D
S
S
N
E
A
R
A
L
R
L
L
E
A
A
G
F
I
R
M
-
R
A
---
G
S
---
G
L
-
F
A
T
V
E
D
V
Q
Q
N
V
R
N
V
V
L
Q
E
V
E
S
A
L
L
P
R
V
F
--
D
Q
V
D
G
A
V
I
N
G
N
Y
A
I
M
A
G
L
-
S
-
A
-
R
-
R
-
D
G
L
A
V
E
P
D
-
A
S
A
--
Y
A
N
V
L
V
V
K
R
G
N
-
E
-
A
D
A
R
V
Q
A
V
L
R
A
L
C
G
-------------------------------------
18
PsiBlast_CBE
74.31
37%
-22
- C5 -
-
4IB2
2
?
B:
[10-250]
--------------------------------
A
K
T
I
K
V
A
A
S
A
T
P
H
A
E
--
I
L
E
Q
A
K
S
I
-
L
-
K
-
K
E
G
Y
Q
L
E
V
T
V
F
D
D
Y
V
Q
P
N
E
V
V
E
S
G
E
F
D
A
N
Y
F
Q
H
V
P
Y
L
E
S
F
N
E
E
-
K
G
T
-
H
L
V
D
A
G
D
I
H
Y
E
P
F
G
I
Y
P
G
T
K
K
S
------
L
D
E
I
-
S
E
-
G
D
K
I
A
V
P
N
D
T
T
N
E
A
R
A
L
L
L
L
Q
D
N
G
I
I
T
L
-
K
D
---
G
A
---
G
L
-
N
A
T
V
N
D
I
E
E
N
P
Y
N
V
E
I
V
E
L
E
A
A
Q
V
A
R
V
T
--
G
E
T
A
Y
V
V
L
N
G
N
Y
A
L
E
A
G
Y
-
S
-
V
A
K
-
D
-
A
L
A
Y
E
K
S
D
S
E
A
A
K
T
Y
V
N
I
I
A
V
K
----
E
-
G
N
E
K
E
E
K
I
Q
A
L
V
K
A
L
K
S
D
E
I
K
E
Y
I
E
K
T
Y
D
G
A
-
V
I
P
----------------
6
PsiBlast_PDB
73.40
37%
-17
- C5 -
-
4IB2
2
?
A:
[6-250]
----------------------------
S
S
E
D
A
K
T
I
K
V
A
A
S
A
T
P
H
A
E
--
I
L
E
Q
A
K
S
I
-
L
-
K
-
K
E
G
Y
Q
L
E
V
T
V
F
D
D
Y
V
Q
P
N
E
V
V
E
S
G
E
F
D
A
N
Y
F
Q
H
V
P
Y
L
E
S
F
N
E
E
-
K
G
T
-
H
L
V
D
A
G
D
I
H
Y
E
P
F
G
I
Y
P
G
T
K
K
S
------
L
D
E
I
-
S
E
-
G
D
K
I
A
V
P
N
D
T
T
N
E
A
R
A
L
L
L
L
Q
D
N
G
I
I
T
L
-
K
D
---
G
A
---
G
L
-
N
A
T
V
N
D
I
E
E
N
P
Y
N
V
E
I
V
E
L
E
A
A
Q
V
A
R
V
T
--
G
E
T
A
Y
V
V
L
N
G
N
Y
A
L
E
A
G
Y
-
S
-
V
A
K
-
D
-
A
L
A
Y
E
K
S
D
S
E
A
A
K
T
Y
V
N
I
I
A
V
K
----
E
-
G
N
E
K
E
E
K
I
Q
A
L
V
K
A
L
K
S
D
E
I
K
E
Y
I
E
K
T
Y
D
G
A
-
V
I
P
----------------
40
HHSearch
72.43
30%
0
- C5 -
-
1XS5
-
TPN32_TREPA
A:
[2-240]
--------------------------------
D
E
T
V
G
V
G
V
L
S
--
E
P
H
A
R
L
L
E
I
A
K
E
E
-
V
-
K
-
K
Q
H
I
E
L
R
I
V
E
F
T
N
Y
V
A
L
N
E
A
V
M
R
G
D
I
L
M
N
F
F
Q
H
V
P
H
M
Q
Q
F
N
Q
E
-
H
N
G
-
D
L
V
S
V
G
N
V
H
V
E
P
L
A
L
Y
S
R
------
T
Y
R
H
V
S
D
F
--
P
A
G
A
V
I
A
I
P
N
D
S
S
N
E
A
R
A
L
R
L
L
E
A
A
G
F
I
R
M
-
R
A
---
G
S
---
G
L
-
F
A
T
V
E
D
V
Q
Q
N
V
R
N
V
V
L
Q
E
V
E
S
A
L
L
P
R
V
F
--
D
Q
V
D
G
A
V
I
N
G
N
Y
A
I
M
A
G
L
-
S
-
A
R
R
-
D
-
G
L
A
V
E
P
D
----
A
S
A
Y
A
N
V
L
V
V
K
R
G
N
---
E
A
D
--
A
R
V
Q
A
V
L
R
A
L
C
G
G
R
V
R
T
Y
L
K
E
R
Y
K
G
G
E
V
A
P
A
---------------
19
Fugue
72.02
38%
45
- C5 -
-
1P99
1
?
A:
[40-294]
----------------------------------
K
V
T
I
G
V
---
A
S
N
D
T
K
A
W
E
K
V
K
E
L
-
A
-
K
-
K
D
D
I
D
V
E
I
K
H
F
S
D
Y
N
L
P
N
K
A
L
N
D
G
D
I
D
M
N
A
F
Q
H
F
A
F
L
D
Q
Y
K
K
A
-
H
K
G
T
K
I
S
A
L
S
T
T
V
L
A
P
L
G
I
Y
S
------
D
K
I
K
D
V
K
K
V
-
K
D
-
G
A
K
V
V
I
P
N
D
V
S
N
Q
A
R
A
L
K
L
L
E
A
A
G
L
I
K
L
-
K
K
---
D
F
---
G
L
-
A
G
T
V
K
D
I
T
S
N
P
K
H
L
K
I
T
A
V
D
A
Q
Q
T
A
R
A
L
--
S
D
V
D
I
A
V
I
N
N
G
V
A
T
K
A
G
K
-
D
-
P
-
K
-
N
D
P
I
F
L
E
K
S
N
S
D
A
V
K
P
Y
I
N
I
V
A
V
N
D
K
D
-
L
-
D
N
---
K
T
Y
A
K
I
V
E
L
Y
H
S
K
E
A
Q
K
A
L
Q
E
D
V
K
D
G
-
E
K
P
V
N
L
S
K
D
E
I
K
A
I
E
T
S
L
A
39
HHSearch
70.11
38%
18
- C5 -
-
4IB2
2
?
A:
[7-251]
-----------------------------
S
E
D
A
K
T
I
K
V
A
A
S
A
--
T
P
H
A
E
I
L
E
Q
A
K
S
I
-
L
-
K
-
K
E
G
Y
Q
L
E
V
T
V
F
D
D
Y
V
Q
P
N
E
V
V
E
S
G
E
F
D
A
N
Y
F
Q
H
V
P
Y
L
E
S
F
N
E
E
-
K
G
T
-
H
L
V
D
A
G
D
I
H
Y
E
P
F
G
I
Y
P
G
------
T
K
K
S
L
D
E
I
--
S
E
G
D
K
I
A
V
P
N
D
T
T
N
E
A
R
A
L
L
L
L
Q
D
N
G
I
I
T
L
-
K
D
---
G
A
---
G
L
-
N
A
T
V
N
D
I
E
E
N
P
Y
N
V
E
I
V
E
L
E
A
A
Q
V
A
R
V
T
--
G
E
T
A
Y
V
V
L
N
G
N
Y
A
L
E
A
G
Y
-
S
-
V
A
K
-
D
-
A
L
A
Y
E
K
S
D
S
E
A
A
K
T
Y
V
N
I
I
A
V
K
E
G
N
---
E
K
E
--
E
K
I
Q
A
L
V
K
A
L
K
S
D
E
I
K
E
Y
I
E
K
T
Y
D
G
A
-
V
I
P
F
---------------
32
HHSearch
70.10
29%
13
- C5 -
-
4NTL
3
?
A:
[6-247]
--------------------------------
D
K
E
I
T
V
A
V
Q
L
--
E
S
S
K
D
I
L
E
I
A
K
K
E
-
A
-
E
-
K
K
G
Y
K
I
N
I
M
E
V
S
D
N
V
A
Y
N
D
A
V
Q
H
D
E
A
D
A
N
F
A
Q
H
Q
P
F
M
E
M
F
N
K
E
-
K
K
A
-
D
L
V
A
V
Q
P
I
Y
Y
F
A
G
G
F
Y
S
K
------
E
Y
Q
D
A
K
D
L
--
P
E
N
A
K
V
G
I
P
S
D
P
T
N
E
G
R
A
L
A
I
L
N
A
N
G
V
I
K
L
-
K
E
---
G
V
---
G
F
-
N
G
T
V
A
D
V
V
E
N
P
K
N
I
T
F
E
S
I
D
L
L
N
L
A
K
A
Y
D
E
K
D
I
A
M
V
F
C
Y
P
A
Y
L
E
P
A
G
L
-
T
-
T
-
K
-
D
-
A
I
L
L
E
D
K
E
--
A
S
K
H
Y
A
L
Q
V
V
T
R
K
G
E
---
K
D
S
--
E
K
I
K
V
L
K
E
A
M
T
T
K
E
V
A
E
Y
I
K
K
N
S
K
G
A
-
N
I
P
A
F
--------------
46
HHSearch
69.70
38%
28
* C5 *
-
1P99
1
?
A:
[40-275]
----------------------------------
K
V
T
I
G
V
A
S
--
N
-
D
T
K
A
W
E
K
V
K
E
L
-
A
-
K
-
K
D
D
I
D
V
E
I
K
H
F
S
D
Y
N
L
P
N
K
A
L
N
D
G
D
I
D
M
N
A
F
Q
H
F
A
F
L
D
Q
Y
K
K
A
H
K
G
T
-
K
I
S
A
L
S
T
T
V
L
A
P
L
G
I
Y
S
D
------
K
I
K
D
V
K
K
V
--
K
D
G
A
K
V
V
I
P
N
D
V
S
N
Q
A
R
A
L
K
L
L
E
A
A
G
L
I
K
L
-
K
K
---
D
F
---
G
L
-
A
G
T
V
K
D
I
T
S
N
P
K
H
L
K
I
T
A
V
D
A
Q
Q
T
A
R
A
L
--
S
D
V
D
I
A
V
I
N
N
G
V
A
T
K
A
G
K
-
D
-
P
K
N
-
D
-
P
I
F
L
E
K
S
N
S
D
A
V
K
P
Y
I
N
I
V
A
V
N
D
K
D
---
L
D
N
--
K
T
Y
A
K
I
V
E
L
Y
H
S
K
E
A
Q
K
A
L
Q
E
D
V
K
D
G
--------------------
11
PsiBlast_PDB
68.98
34%
-10
- C5 -
-
3GXA
-
?
A:
[40-258]
---------------------------------------------------
E
Q
I
Q
P
E
-
L
-
E
-
K
K
G
Y
T
V
K
L
V
E
F
T
D
Y
V
R
P
N
L
A
L
A
E
G
E
L
D
I
N
V
F
Q
H
K
P
Y
L
D
D
F
K
K
E
-
H
N
L
-
D
I
T
E
V
F
Q
V
P
T
A
P
L
G
L
Y
P
G
------
K
L
K
S
L
E
E
V
-
K
D
-
G
S
T
V
S
A
P
N
D
P
S
N
F
A
R
V
L
V
M
L
D
E
L
G
W
I
K
L
K
D
G
---
I
N
---
P
L
-
T
A
S
K
A
D
I
A
E
N
L
K
N
I
K
I
V
E
L
E
A
A
Q
L
P
R
S
R
--
A
D
V
D
F
A
V
V
N
G
N
Y
A
I
S
S
G
M
-
K
-
L
-
T
-
E
-
A
L
F
Q
E
P
S
F
-
A
Y
V
-
N
W
S
A
V
K
T
A
D
K
D
--------
S
Q
W
L
K
D
V
T
E
A
Y
N
S
D
A
F
K
A
Y
A
H
K
R
F
E
G
Y
-
K
S
P
----------------
4
PsiBlast_PDB
68.96
39%
59
- C5 -
-
4QHQ
1
?
A:
[1-235]
----------------------------------
V
I
K
V
G
T
V
--
A
G
P
D
S
E
V
W
Q
V
V
Q
K
V
-
A
-
K
E
K
E
G
L
N
V
K
V
I
E
F
N
D
Y
V
Q
P
N
A
A
L
D
S
G
D
L
D
A
N
S
F
Q
H
Q
P
Y
L
D
S
Q
V
K
Q
-
R
G
Y
-
K
I
V
S
A
G
L
T
Y
I
S
P
I
G
V
Y
S
------
K
K
F
K
S
L
K
D
L
-
P
Q
-
G
A
K
L
A
V
P
N
D
P
S
N
E
N
R
A
L
L
L
L
Q
T
Q
G
V
I
K
L
-
K
A
GAG
T
G
---
G
N
-
N
A
T
V
L
D
I
A
E
N
P
K
K
L
K
I
S
E
L
D
A
A
Q
L
P
R
V
L
--
S
D
V
D
A
A
V
I
N
T
N
Y
A
L
A
A
N
L
-
Q
P
T
-
K
-
D
-
A
I
A
L
E
S
L
----
T
S
P
Y
A
N
L
I
A
V
R
A
K
D
-
K
-
D
Q
P
---
W
V
K
K
L
V
K
A
Y
Q
S
P
E
V
K
E
F
I
K
K
Q
F
K
G
---------------------
10
PsiBlast_PDB
67.87
34%
-9
- C5 -
-
3IR1
-
?
A:
[18-236]
---------------------------------------------------
E
Q
I
Q
P
E
-
L
-
E
-
K
K
G
Y
T
V
K
L
V
E
F
T
D
Y
V
R
P
N
L
A
L
A
E
G
E
L
D
I
N
V
F
Q
H
K
P
Y
L
D
D
F
K
K
E
-
H
N
L
-
D
I
T
E
V
F
Q
V
P
T
A
P
L
G
L
Y
P
G
------
K
L
K
S
L
E
E
V
-
K
D
-
G
S
T
V
S
A
P
N
D
P
S
N
F
A
R
V
L
V
M
L
D
E
L
G
W
I
K
L
K
D
G
---
I
N
---
P
L
-
T
A
S
K
A
D
I
A
E
N
L
K
N
I
K
I
V
E
L
E
A
A
Q
L
P
R
S
R
--
A
D
V
D
F
A
V
V
N
G
N
Y
A
I
S
S
G
M
-
K
-
L
-
T
-
E
-
A
L
F
Q
E
P
S
F
-
A
Y
V
-
N
W
S
A
V
K
T
A
D
K
D
--------
S
Q
W
L
K
D
V
T
E
A
Y
N
S
D
A
F
K
A
Y
A
H
K
R
F
E
G
Y
-
K
S
P
----------------
5
PsiBlast_PDB
66.49
36%
65
- C5 -
-
4YAH
-
METQ_ECOLI
X:
[29-255]
----------------------------
D
P
N
H
---
I
K
V
G
V
I
--
V
G
A
E
Q
Q
V
A
E
V
A
Q
K
V
-
A
-
K
D
K
Y
G
L
D
V
E
L
V
T
F
N
D
Y
V
L
P
N
E
A
L
S
K
G
D
I
D
A
N
A
F
Q
H
K
P
Y
L
D
Q
Q
L
K
D
-
R
G
Y
-
K
L
V
A
V
G
N
T
F
V
Y
P
I
A
G
Y
S
------
K
K
I
K
S
L
D
E
L
-
Q
D
-
G
S
Q
V
A
V
P
N
D
P
T
N
L
G
R
S
L
L
L
L
Q
K
V
G
L
I
K
L
-
K
D
---
G
V
---
G
L
-
L
P
T
V
L
D
V
V
E
N
P
K
N
L
K
I
V
E
L
E
A
P
Q
L
P
R
S
L
DD
A
Q
I
A
L
A
V
I
N
T
T
Y
A
S
Q
I
G
L
T
P
-
A
-
K
-
D
-
G
I
F
V
E
----
D
K
E
S
P
Y
V
N
L
I
V
T
R
E
D
-----
N
K
D
A
E
N
V
K
K
F
V
Q
A
Y
Q
S
D
E
V
-------------------------------
8
PsiBlast_PDB
65.58
34%
42
- C5 -
-
3TQW
-
?
A:
[5-225]
-----------------------------------
V
R
V
G
T
I
--
A
G
P
E
T
Q
L
M
E
V
A
K
Q
V
A
L
-
N
-
R
Y
G
L
H
V
N
I
I
T
F
S
D
Y
N
T
P
N
E
A
L
A
D
G
S
V
D
A
N
M
F
Q
H
L
P
Y
L
K
A
Q
I
E
M
-
R
G
Y
-
K
I
V
S
I
G
K
T
F
V
Y
P
M
G
L
Y
S
------
K
K
I
T
A
L
T
Q
L
-
K
T
-
G
A
K
I
A
V
P
S
D
P
S
N
E
A
R
A
L
L
L
L
E
K
A
Q
L
I
Q
L
-
K
T
---
H
-----
I
-
N
A
T
P
M
D
I
A
S
N
P
K
K
L
K
I
V
E
L
D
A
A
Q
L
S
R
S
L
--
G
D
V
D
L
A
A
I
N
T
N
Y
A
I
P
A
G
L
-
S
-
P
-
S
-
R
D
A
L
L
T
E
G
P
N
-
S
---
P
Y
A
N
V
V
A
V
R
E
D
D
-
K
-
N
D
P
R
---
L
K
Q
L
V
S
A
L
H
S
P
A
V
-------------------------------
33
HHSearch
64.90
38%
0
- C- -
-
4K3F
-
?
A:
[2--1]
--------------------------------
A
E
S
L
T
V
A
A
T
P
--
V
P
H
A
E
I
L
N
V
V
K
P
L
-
L
-
A
-
K
E
G
V
D
L
K
I
K
E
F
T
D
Y
V
Q
P
N
V
Q
V
S
E
K
R
L
D
A
N
F
F
Q
H
Q
P
Y
L
D
E
F
N
K
A
-
K
G
T
-
D
L
V
A
V
T
G
V
H
I
E
P
L
G
A
Y
S
S
------
K
Y
K
K
L
D
E
L
--
P
S
G
A
T
V
V
I
P
N
D
A
T
N
G
G
R
A
L
L
L
L
D
K
A
G
V
I
K
L
-
K
D
---
N
K
---
S
I
-
T
A
T
P
K
D
I
V
D
N
P
K
N
I
K
I
R
E
L
E
A
A
T
L
P
R
V
L
--
T
Q
V
D
M
A
L
I
N
T
N
Y
A
L
E
A
K
L
-
N
-
P
T
K
-
D
-
A
L
A
I
E
G
S
---
D
-
S
P
Y
V
N
I
L
V
A
R
P
D
N
---
K
D
S
--
D
A
M
Q
K
L
A
K
A
L
H
S
A
E
I
K
Q
F
I
Q
E
K
Y
K
G
A
-
V
V
P
A
F
--------------
43
HHSearch
64.64
34%
28
- C5 -
-
3IR1
-
?
F:
[2-236]
----------------------------------
E
I
V
F
G
T
T
V
G
-
D
F
G
D
M
V
K
E
Q
I
Q
P
E
-
L
-
E
-
K
K
G
Y
T
V
K
L
V
E
F
T
D
Y
V
R
P
N
L
A
L
A
E
G
E
L
D
I
N
V
F
Q
H
K
P
Y
L
D
D
F
K
K
E
-
H
N
L
-
D
I
T
E
V
F
Q
V
P
T
A
P
L
G
L
Y
P
G
------
K
L
K
S
L
E
E
V
--
K
D
G
S
T
V
S
A
P
N
D
P
S
N
F
A
R
V
L
V
M
L
D
E
L
G
W
I
K
L
-
K
D
---
G
I
---
N
P
L
T
A
S
K
A
D
I
A
E
N
L
K
N
I
K
I
V
E
L
E
A
A
Q
L
P
R
S
R
--
A
D
V
D
F
A
V
V
N
G
N
Y
A
I
S
S
G
M
-
K
-
L
-
T
-
E
-
A
L
F
Q
E
P
S
----
F
-
A
Y
V
N
W
S
A
V
K
T
A
D
---
K
D
S
--
Q
W
L
K
D
V
T
E
A
Y
N
S
D
A
F
K
A
Y
A
H
K
R
F
E
G
Y
-
K
S
P
----------------
47
HHSearch
64.42
40%
62
- C5 -
-
4QHQ
1
?
A:
[1-241]
----------------------------------
V
I
K
V
G
T
V
A
G
-
P
D
S
E
V
W
Q
V
V
-
Q
K
V
-
A
K
E
-
K
E
G
L
N
V
K
V
I
E
F
N
D
Y
V
Q
P
N
A
A
L
D
S
G
D
L
D
A
N
S
F
Q
H
Q
P
Y
L
D
S
Q
V
K
Q
-
R
G
Y
-
K
I
V
S
A
G
L
T
Y
I
S
P
I
G
V
Y
S
------
K
K
F
K
S
L
K
D
L
P
Q
--
G
A
K
L
A
V
P
N
D
P
S
N
E
N
R
A
L
L
L
L
Q
T
Q
G
V
I
K
L
-
K
A
---
G
A
GTG
G
N
-
N
A
T
V
L
D
I
A
E
N
P
K
K
L
K
I
S
E
L
D
A
A
Q
L
P
R
V
L
--
S
D
V
D
A
A
V
I
N
T
N
Y
A
L
A
A
N
L
-
Q
-
P
-
T
K
D
-
A
I
A
L
E
S
L
----
T
S
P
Y
A
N
L
I
A
V
R
A
K
D
-
K
-
D
Q
P
---
W
V
K
K
L
V
K
A
Y
Q
S
P
E
V
K
E
F
I
K
K
Q
F
K
G
S
-
M
V
A
S
F
--------------
3
PsiBlast_PDB
63.43
39%
0
- C- -
-
4K3F
-
?
A:
[21--1]
-----------------------------------------------------
V
K
P
L
-
L
-
A
-
K
E
G
V
D
L
K
I
K
E
F
T
D
Y
V
Q
P
N
V
Q
V
S
E
K
R
L
D
A
N
F
F
Q
H
Q
P
Y
L
D
E
F
N
K
A
-
K
G
T
-
D
L
V
A
V
T
G
V
H
I
E
P
L
G
A
Y
S
------
S
K
Y
K
K
L
D
E
L
-
P
S
-
G
A
T
V
V
I
P
N
D
A
T
N
G
G
R
A
L
L
L
L
D
K
A
G
V
I
K
L
-
K
D
---
N
K
---
S
I
-
T
A
T
P
K
D
I
V
D
N
P
K
N
I
K
I
R
E
L
E
A
A
T
L
P
R
V
L
--
T
Q
V
D
M
A
L
I
N
T
N
Y
A
L
E
A
K
L
-
N
P
T
-
K
-
D
-
A
L
A
I
E
G
S
D
-
S
---
P
Y
V
N
I
L
V
A
R
P
D
N
-
K
-
D
S
---
D
A
M
Q
K
L
A
K
A
L
H
S
A
E
I
K
Q
F
I
Q
E
K
Y
K
G
A
-
V
V
P
A
F
--------------
44
HHSearch
63.29
34%
28
- C5 -
-
3IR1
-
?
D:
[2-236]
----------------------------------
E
I
V
F
G
T
T
V
G
-
D
F
G
D
M
V
K
E
Q
I
Q
P
E
-
L
-
E
-
K
K
G
Y
T
V
K
L
V
E
F
T
D
Y
V
R
P
N
L
A
L
A
E
G
E
L
D
I
N
V
F
Q
H
K
P
Y
L
D
D
F
K
K
E
-
H
N
L
-
D
I
T
E
V
F
Q
V
P
T
A
P
L
G
L
Y
P
G
------
K
L
K
S
L
E
E
V
--
K
D
G
S
T
V
S
A
P
N
D
P
S
N
F
A
R
V
L
V
M
L
D
E
L
G
W
I
K
L
-
K
D
---
G
I
---
N
P
L
T
A
S
K
A
D
I
A
E
N
L
K
N
I
K
I
V
E
L
E
A
A
Q
L
P
R
S
R
--
A
D
V
D
F
A
V
V
N
G
N
Y
A
I
S
S
G
M
-
K
-
L
-
T
-
E
-
A
L
F
Q
E
P
S
----
F
-
A
Y
V
N
W
S
A
V
K
T
A
D
---
K
D
S
--
Q
W
L
K
D
V
T
E
A
Y
N
S
D
A
F
K
A
Y
A
H
K
R
F
E
G
Y
-
K
S
P
----------------