@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0318: (2017-12-19 )
MKIAVAGTGYVGLSIAVLLSQQHQVMAVDIIPEKVELINQRKSPIQDDYIEKYLAKKDLNLVATLDAKEAYQDADFVVIAAPTNYDPKKNFFDTSAVESVIETALKYNPDAIMVIKSTVPVGYTESARKKFQTENILFSPEFLRESKALYDNLYPSRIILGTDKNNERLVSAAETFARLLQEGALKENIDTLYMGFTEAEAVKLFANTYLALRVSYFNELDTYSEMKGLDTQAIIDGVGLDPRIGSHYNNPSFGYGGYCLPKDTKQLLANYEDIPEELIGAIVRSNSTRKDFIADQVLKMVDYYDYSAHNIFDERVEKDIIIGIYRLTMKSNSDNFRQSSIQGIMKRIKAKGVRVVIYEPTLESGSTFFGSSVINDLEEFKRLSNAIVANRYDNSLEDVKEKVYTRDIFERD
Atome Classification :
(20 SA)
-------.........10........20---.--.---......30.----.......40....--....50.....--...60........70....--....80......----.----.90-........100.....----.---.110.......120.......130---------.---------..----------.....140.......150.......160...-...-.170.-.......180.......190.......200.......210.......220.......230.......240--....--...250.......260.......270-.------.--..---....280.......290.......300.......310.......320.......330.......340.......350.......360---------........---.----------------370.......380....---...390..----.....400-----------.---------.-------.......410------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------
M
K
I
A
V
AGTGY
V
G
L
S
I
A
V
L
LSQ---Q--
H
---
Q
V
M
A
V
DII
P
----
E
K
V
E
L
I
N
QRKSPI--
Q
D
D
Y
I
E
K
Y
L
A
K--KDL
N
L
V
A
T
L
D
A
K
E
AYQDA
D
--
F
V
V
I
AAPTNYDP----K----KNF-F
D
T
S
A
V
E
S
V
I
E
T
A
LKY----N---P
D
A
I
M
V
I
KSTVPVGY
T
E
S
A
R
K
KF----------Q---------TE----------NILF
S
P
E
F
L
R
E
S
K
A
L
Y
DNLYP
S
R
I
I
L
GTDKN-
N
E
R
-
L
V
-
S
A
-
A
E
T
F
A
R
L
L
Q
EGALKEN
I
D
T
L
Y
MGFT
E
A
E
A
V
K
L
F
A
N
T
Y
L
A
L
R
V
S
Y
F
NEL
D
T
Y
S
E
MKGL
D
T
Q
A
IIDGVGLDP--RIGS--HYNNPSFGYGGYCL
P
K
D
T
K
Q
L
L
A
N
Y
--
E
------
D
--
I
P
---
E
E
L
I
G
A
I
V
RSNST
R
K
D
F
I
A
D
Q
V
L
K
M
V
D
YYDY
S
A
H
N
I
F
D
E
R
VEK
D
I
I
I
G
I
Y
R
L
T
MKSNSDN
F
R
Q
S
S
I
Q
G
I
M
K
R
I
K
AKG
V
R
V
V
I
YEP-----------TLESGSTF---
F
----------------
G
S
S
V
I
N
D
L
E
E
F
K
R
L
S
N
A
---
I
V
ANRYDN----
S
L
E
D
V
K
-------------
E
---------
K
-------
V
Y
T
R
D
I
FERD------------------
22
HHSearch
95.15
61%
-101
- C1 -
-
3PJG
3
?
A:
[37-424]
-------
M
K
I
T
I
S
G
T
G
Y
V
G
L
S
N
G
V
L
I
A
Q
---
N
--
H
---
E
V
V
A
L
D
I
V
Q
----
A
K
V
D
M
L
N
Q
K
I
S
P
I
--
V
D
K
E
I
Q
E
Y
L
A
E
--
K
P
L
N
F
R
A
T
T
D
K
H
D
A
Y
R
N
A
D
--
Y
V
I
I
A
T
P
T
D
Y
D
P
----
K
----
T
N
Y
-
F
N
T
S
T
V
E
A
V
I
R
D
V
T
E
I
----
N
---
P
N
A
V
M
I
I
K
S
T
I
P
V
G
F
T
R
D
I
K
E
R
L
----------
G
---------
I
D
----------
N
V
I
F
S
P
E
F
L
R
E
G
R
A
L
Y
D
N
L
H
P
S
R
I
V
I
G
E
R
S
A
---------
R
-
A
E
R
F
A
D
L
L
K
E
G
A
I
K
Q
D
I
P
T
L
F
T
D
S
T
E
A
E
A
I
K
L
F
A
N
T
Y
L
A
L
R
V
A
Y
F
N
E
L
D
S
Y
A
E
S
Q
G
L
N
S
K
Q
I
I
E
G
V
C
L
D
P
--
R
I
G
N
--
H
Y
N
N
P
S
F
G
Y
G
G
Y
C
L
P
K
D
T
K
Q
L
L
A
N
Y
--
E
------
S
--
V
P
---
N
N
I
I
A
A
I
V
D
A
N
R
T
R
K
D
F
I
A
D
S
I
L
A
-----------------
R
K
P
K
V
V
G
V
Y
R
L
I
M
K
S
G
S
D
N
F
R
A
S
S
I
Q
G
I
M
K
R
I
K
A
K
G
I
P
V
I
I
Y
E
P
-----------
V
M
Q
E
D
-
E
F
---
F
----------------
N
S
R
V
V
R
D
L
N
A
F
K
Q
E
A
D
V
---
I
I
S
N
R
M
A
E
----
E
L
A
D
V
A
-------------
D
---------
K
-------
V
Y
T
R
D
L
F
G
N
D
------------------
1
PsiBlast_PDB
93.50
57%
-101
- C1 -
-
3PJG
3
?
A:
[37-424]
-------
M
K
I
T
I
S
G
T
G
Y
V
G
L
S
N
G
V
L
I
A
Q
---
N
--
H
---
E
V
V
A
L
D
I
V
Q
----
A
K
V
D
M
L
N
Q
K
I
S
P
I
--
V
D
K
E
I
Q
E
Y
L
A
E
--
K
P
L
N
F
R
A
T
T
D
K
H
D
A
Y
R
N
A
D
--
Y
V
I
I
A
T
P
T
D
Y
D
P
----
K
----
T
N
Y
-
F
N
T
S
T
V
E
A
V
I
R
D
V
T
E
I
----
N
---
P
N
A
V
M
I
I
K
S
T
I
P
V
G
F
T
R
D
I
K
E
R
L
----------
G
---------
I
D
----------
N
V
I
F
S
P
E
F
L
R
E
G
R
A
L
Y
D
N
L
H
P
S
R
I
V
I
G
------
E
R
--
S
-
A
R
-
A
E
R
F
A
D
L
L
K
E
G
A
I
K
Q
D
I
P
T
L
F
T
D
S
T
E
A
E
A
I
K
L
F
A
N
T
Y
L
A
L
R
V
A
Y
F
N
E
L
D
S
Y
A
E
S
Q
G
L
N
S
K
Q
I
I
E
G
V
C
L
D
P
--
R
I
G
N
--
H
Y
N
N
P
S
F
G
Y
G
G
Y
C
L
P
K
D
T
K
Q
L
L
A
N
Y
--
E
------
S
--
V
P
---
N
N
I
I
A
A
I
V
D
A
N
R
T
R
K
D
F
I
A
D
S
I
L
-----------------
A
R
K
P
K
V
V
G
V
Y
R
L
I
M
K
S
G
S
D
N
F
R
A
S
S
I
Q
G
I
M
K
R
I
K
A
K
G
I
P
V
I
I
Y
E
P
-----------
V
M
Q
E
-
D
E
F
---
F
----------------
N
S
R
V
V
R
D
L
N
A
F
K
Q
E
A
D
V
---
I
I
S
N
R
M
A
E
----
E
L
A
D
V
A
-------------
D
---------
K
-------
V
Y
T
R
D
L
F
G
N
D
------------------
23
HHSearch
90.60
59%
-47
- C1 -
-
1DLJ
5
UDG_STRPY
A:
[1-402]
-------
M
K
I
A
V
A
G
S
G
Y
V
G
L
S
L
G
V
L
L
S
L
---
Q
--
N
---
E
V
T
I
V
D
I
L
P
----
S
K
V
D
K
I
N
N
G
L
S
P
I
--
Q
D
E
Y
I
E
Y
Y
L
K
S
--
K
Q
L
S
I
K
A
T
L
D
S
K
A
A
Y
K
E
A
E
--
L
V
I
I
A
T
P
T
N
Y
N
S
----
R
----
I
N
Y
-
F
D
T
Q
H
V
E
T
V
I
K
E
V
L
S
V
----
N
---
S
H
A
T
L
I
I
K
S
T
I
P
I
G
F
I
T
E
M
R
Q
K
F
----------
Q
---------
T
D
----------
R
I
I
F
S
P
E
F
L
R
E
S
K
A
L
Y
D
N
L
Y
P
S
R
I
I
V
S
C
E
E
N
-
D
S
P
-
K
V
K
A
D
-
A
E
K
F
A
L
L
L
K
S
A
A
K
K
N
N
V
P
V
L
I
M
G
A
S
E
A
E
A
V
K
L
F
A
N
T
Y
L
A
L
R
V
A
Y
F
N
E
L
D
T
Y
A
E
S
R
K
L
N
S
H
M
I
I
Q
G
I
S
Y
D
D
--
R
I
G
M
--
H
Y
N
N
P
S
F
G
Y
G
G
Y
S
L
P
K
D
T
K
Q
L
L
A
N
Y
--
N
------
N
--
I
P
---
Q
T
L
I
E
A
I
V
S
S
N
N
V
R
K
S
Y
I
A
K
Q
I
I
N
V
L
K
E
Q
-----------
E
S
P
V
K
V
V
G
V
Y
R
L
I
M
K
S
N
S
D
N
F
R
E
S
A
I
K
D
V
I
D
I
L
K
S
K
D
I
K
I
I
I
Y
E
P
-----------
M
L
N
K
L
-
E
S
E--
D
----------------
Q
S
V
L
V
N
D
L
E
N
F
K
K
Q
A
N
I
---
I
V
T
N
R
Y
D
N
----
E
L
Q
D
V
K
-------------
N
---------
K
-------
V
Y
S
R
D
I
F
G
R
D
------------------
43
Fugue
89.68
58%
-46
- C1 -
-
1DLJ
5
UDG_STRPY
A:
[1-402]
-------
M
K
I
A
V
A
G
S
G
Y
V
G
L
S
L
G
V
L
L
S
L
---
Q
--
N
---
E
V
T
I
V
D
I
L
P
----
S
K
V
D
K
I
N
N
G
L
S
P
I
--
Q
D
E
Y
I
E
Y
Y
L
K
S
--
K
Q
L
S
I
K
A
T
L
D
S
K
A
A
Y
K
E
A
E
--
L
V
I
I
A
T
P
T
N
Y
N
S
----
R
----
I
N
Y
-
F
D
T
Q
H
V
E
T
V
I
K
E
V
L
S
V
----
N
---
S
H
A
T
L
I
I
K
S
T
I
P
I
G
F
I
T
E
M
R
Q
K
F
----------
Q
---------
T
D
----------
R
I
I
F
S
P
E
F
L
R
E
S
K
A
L
Y
D
N
L
Y
P
S
R
I
I
V
S
C
E
E
N
D
S
P
K
-
V
K
-
A
D
-
A
E
K
F
A
L
L
L
K
S
A
A
K
K
N
N
V
P
V
L
I
M
G
A
S
E
A
E
A
V
K
L
F
A
N
T
Y
L
A
L
R
V
A
Y
F
N
E
L
D
T
Y
A
E
S
R
K
L
N
S
H
M
I
I
Q
G
I
S
Y
D
D
--
R
I
G
M
--
H
Y
N
N
P
S
F
G
Y
G
G
Y
S
L
P
K
D
T
K
Q
L
L
A
N
Y
--
N
------
N
--
I
P
---
Q
T
L
I
E
A
I
V
S
S
N
N
V
R
K
S
Y
I
A
K
Q
I
I
N
V
L
K
-----------
E
Q
E
S
P
V
K
V
V
G
V
Y
R
L
I
M
K
S
N
S
D
N
F
R
E
S
A
I
K
D
V
I
D
I
L
K
S
K
D
I
K
I
I
I
Y
E
P
-----------
M
L
N
K
L
E
S
E
---
D
----------------
Q
S
V
L
V
N
D
L
E
N
F
K
K
Q
A
N
I
---
I
V
T
N
R
Y
D
N
----
E
L
Q
D
V
K
-------------
N
---------
K
-------
V
Y
S
R
D
I
F
G
R
D
------------------
3
PsiBlast_PDB
89.21
57%
-47
- C1 -
-
1DLJ
5
UDG_STRPY
A:
[1-402]
-------
M
K
I
A
V
A
G
S
G
Y
V
G
L
S
L
G
V
L
L
S
L
---
Q
--
N
---
E
V
T
I
V
D
I
L
P
----
S
K
V
D
K
I
N
N
G
L
S
P
I
--
Q
D
E
Y
I
E
Y
Y
L
K
S
--
K
Q
L
S
I
K
A
T
L
D
S
K
A
A
Y
K
E
A
E
--
L
V
I
I
A
T
P
T
N
Y
N
S
----
R
----
I
N
Y
-
F
D
T
Q
H
V
E
T
V
I
K
E
V
L
S
V
----
N
---
S
H
A
T
L
I
I
K
S
T
I
P
I
G
F
I
T
E
M
R
Q
K
F
----------
Q
---------
T
D
----------
R
I
I
F
S
P
E
F
L
R
E
S
K
A
L
Y
D
N
L
Y
P
S
R
I
I
V
S
C
E
E
N
-
D
S
P
-
K
V
-
K
A
D
A
E
K
F
A
L
L
L
K
S
A
A
K
K
N
N
V
P
V
L
I
M
G
A
S
E
A
E
A
V
K
L
F
A
N
T
Y
L
A
L
R
V
A
Y
F
N
E
L
D
T
Y
A
E
S
R
K
L
N
S
H
M
I
I
Q
G
I
S
Y
D
D
--
R
I
G
M
--
H
Y
N
N
P
S
F
G
Y
G
G
Y
S
L
P
K
D
T
K
Q
L
L
A
N
Y
--
N
------
N
--
I
P
---
Q
T
L
I
E
A
I
V
S
S
N
N
V
R
K
S
Y
I
A
K
Q
I
I
-----------
N
V
L
K
E
Q
E
S
P
V
K
V
V
G
V
Y
R
L
I
M
K
S
N
S
D
N
F
R
E
S
A
I
K
D
V
I
D
I
L
K
S
K
D
I
K
I
I
I
Y
E
P
-----------
M
L
N
K
L
E
S
E
---
D
----------------
Q
S
V
L
V
N
D
L
E
N
F
K
K
Q
A
N
I
---
I
V
T
N
R
Y
D
N
----
E
L
Q
D
V
K
-------------
N
---------
K
-------
V
Y
S
R
D
I
F
G
R
D
------------------
2
PsiBlast_PDB
89.01
57%
-49
- C1 -
-
1DLI
5
UDG_STRPY
A:
[1-402]
-------
M
K
I
A
V
A
G
S
G
Y
V
G
L
S
L
G
V
L
L
S
L
---
Q
--
N
---
E
V
T
I
V
D
I
L
P
----
S
K
V
D
K
I
N
N
G
L
S
P
I
--
Q
D
E
Y
I
E
Y
Y
L
K
S
--
K
Q
L
S
I
K
A
T
L
D
S
K
A
A
Y
K
E
A
E
--
L
V
I
I
A
T
P
T
N
Y
N
S
----
R
----
I
N
Y
-
F
D
T
Q
H
V
E
T
V
I
K
E
V
L
S
V
----
N
---
S
H
A
T
L
I
I
K
S
T
I
P
I
G
F
I
T
E
M
R
Q
K
F
----------
Q
---------
T
D
----------
R
I
I
F
S
P
E
F
L
R
E
S
K
A
L
Y
D
N
L
Y
P
S
R
I
I
V
S
C
E
E
N
-
D
S
P
-
K
V
-
K
A
D
A
E
K
F
A
L
L
L
K
S
A
A
K
K
N
N
V
P
V
L
I
M
G
A
S
E
A
E
A
V
K
L
F
A
N
T
Y
L
A
L
R
V
A
Y
F
N
E
L
D
T
Y
A
E
S
R
K
L
N
S
H
M
I
I
Q
G
I
S
Y
D
D
--
R
I
G
M
--
H
Y
N
N
P
S
F
G
Y
G
G
Y
C
L
P
K
D
T
K
Q
L
L
A
N
Y
--
N
------
N
--
I
P
---
Q
T
L
I
E
A
I
V
S
S
N
N
V
R
K
S
Y
I
A
K
Q
I
I
-----------
N
V
L
K
E
Q
E
S
P
V
K
V
V
G
V
Y
R
L
I
M
K
S
N
S
D
N
F
R
E
S
A
I
K
D
V
I
D
I
L
K
S
K
D
I
K
I
I
I
Y
E
P
-----------
M
L
N
K
L
E
S
E
---
D
----------------
Q
S
V
L
V
N
D
L
E
N
F
K
K
Q
A
N
I
---
I
V
T
N
R
Y
D
N
----
E
L
Q
D
V
K
-------------
N
---------
K
-------
V
Y
S
R
D
I
F
G
R
D
------------------
28
HHSearch
59.07
26%
-1
- C1 -
-
2O3J
3
UGDH_CAEEL
C:
[10-452]
-------
S
K
V
V
C
V
G
A
G
Y
V
G
G
P
T
C
A
M
I
A
H
KCP
H
--
I
---
T
V
T
V
V
D
M
N
T
----
A
K
I
A
E
W
N
S
D
K
L
P
I
--
Y
E
P
G
L
D
E
I
V
F
A
A-
R
G
R
N
L
F
F
S
S
D
I
P
K
A
I
A
E
A
D
--
L
I
F
I
S
V
N
T
P
T
K
M
----
Y
GRGK
G
M
A
-
P
D
L
K
Y
V
E
S
V
S
R
T
I
A
Q
Y
A---
G
---
G
P
K
I
V
V
E
K
S
T
V
P
V
-
A
A
E
S
I
G
C
I
L
REAQK-----
L
---------
K
F
----------
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
M
K
D
L
A
N
P
D
R
V
L
I
G
G
E
S
S
--
P
E
-
G
L
-
Q
A
-
V
A
E
L
V
R
I
Y
E
N
W
V
-
P
-
R
N
R
I
I
T
T
N
T
W
S
S
E
L
S
K
L
V
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
V
C
E
A
T
G
A
E
I
S
E
V
A
H
A
V
G
Y
D
T
--
R
I
G
S
--
K
F
L
Q
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
S
L
V
Y
L
C
--
E
SL----
N
--
L
P
QV-
A
D
Y
W
Q
G
V
I
N
I
N
N
W
Q
R
R
R
F
A
D
K
I
I
A
E
L
F
N
------------
T
V
T
D
K
K
I
A
I
F
G
F
A
F
K
K
N
T
G
D
T
R
E
S
S
A
I
H
V
I
K
H
L
M
E
E
H
A
K
L
S
V
Y
D
P
-----------
K
V
Q
K
S
Q
M
L
---
N
DLASVTSAQDVER---
L
I
T
V
E
S
D
P
Y
A
A
A
R
G
A
H
A
---
I
V
V
L
T
E
W
D
----
E
F
V
E
L
N
YSQIHNDMQ----
H
PAA------
I
-------
F
D
G
R
L
I
L
D
Q
-------------------
29
HHSearch
57.02
24%
5
- C1 -
-
3KHU
8
UGDH_HUMAN
B:
[6-448]
-------
K
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
MCP
E
--
I
---
R
V
T
V
V
D
V
N
E
----
S
R
I
N
A
W
N
S
P
T
L
P
I
--
Y
E
P
G
L
K
E
V
V
E
S
C-
R
G
K
N
L
F
F
S
T
N
I
D
D
A
I
K
E
A
D
--
L
V
F
I
S
V
N
T
P
T
K
T
----
Y
GMGK
G
R
A
-
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
N
S---
N
---
G
Y
K
I
V
T
E
K
S
T
V
P
V
R
A
A
E
S
I
R
R
I
F
DANTKPN---
L
---------
N
L
----------
Q
V
L
S
N
P
Q
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
L
I
G
G
D
E
T
--
P
E
-
G
Q
-
R
A
-
V
Q
A
L
C
A
V
Y
E
H
W
V
P
R
--
E
K
I
L
T
T
N
T
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
A
T
A
I
G
M
D
Q
--
R
I
G
N
--
K
F
L
K
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
N
L
V
Y
L
C
EA
L
------
N
--
L
P
EV-
A
R
Y
W
Q
Q
V
I
D
M
N
D
Y
Q
R
R
R
F
A
S
R
I
I
D
S
L
F
N
------------
T
V
T
D
K
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
I
S
K
Y
L
M
D
E
G
A
H
L
H
I
Y
D
P
-----------
K
V
P
R
E
-
Q
I
---
V
VDLSHPGVSEDDQVSR
L
V
T
I
S
K
D
P
Y
E
A
C
D
G
A
H
A
---
V
V
I
C
T
E
W
D
----
M
F
K
E
L
D
YERIHKKMLKPA-
F
---------
I
-------
F
D
G
R
R
V
L
D
G
-------------------
27
HHSearch
56.77
26%
2
- C1 -
-
2O3J
4
UGDH_CAEEL
A:
[10-452]
-------
S
K
V
V
C
V
G
A
G
Y
V
G
G
P
T
C
A
M
I
A
H
K
C
P
H
--
I
---
T
V
T
V
V
D
M
N
T
----
A
K
I
A
E
W
N
S
D
K
L
P
I
--
Y
E
P
G
L
D
E
I
V
F
A
A
-
R
G
R
N
L
F
F
S
S
D
I
P
K
A
I
A
E
A
D
--
L
I
F
I
S
V
N
T
P
T
K
M
----
Y
GRGK
G
M
A
-
P
D
L
K
Y
V
E
S
V
S
R
T
I
A
Q
Y
A---
G
---
G
P
K
I
V
V
E
K
S
T
V
P
V
K
A
A
E
S
I
G
C
I
L
R
E
A
QK-----
L
---------
K
F
----------
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
M
K
D
L
A
N
P
D
R
V
L
I
G
G
E
S
S
--
P
E
-
G
L
-
Q
A
-
V
A
E
L
V
R
I
Y
E
N
W
V
-
P
-
R
N
R
I
I
T
T
N
T
W
S
S
E
L
S
K
L
V
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
V
C
E
A
T
G
A
E
I
S
E
V
A
H
A
V
G
Y
D
T
--
R
I
G
S
--
K
F
L
Q
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
S
L
V
Y
L
C
--
E
S
L
----
N
--
L
P
Q
V
-
A
D
Y
W
Q
G
V
I
N
I
N
N
W
Q
R
R
R
F
A
D
K
I
I
A
E
L
F
N
------------
T
V
T
D
K
K
I
A
I
F
G
F
A
F
K
K
N
T
G
D
T
R
E
S
S
A
I
H
V
I
K
H
L
M
E
E
H
A
K
L
S
V
Y
D
P
-----------
K
V
Q
K
S
Q
M
L
---
N
D
L
A
S
V
TS
A
Q
D
V
E
R
---
L
I
T
V
E
S
D
P
Y
A
A
A
R
G
A
H
A
---
I
V
V
L
T
E
W
D
----
E
F
V
E
L
N
Y
S
Q
I
H
N
D
MQ----
H
P
A
A
------
I
-------
F
D
G
R
L
I
L
D
Q
-------------------
30
HHSearch
56.65
24%
-1
- C1 -
-
5VR8
3
?
E:
[6-448]
-------
K
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
MCP
E
--
I
---
R
V
T
V
V
D
V
N
E
----
S
R
I
N
A
W
N
S
P
T
L
P
I
--
Y
E
P
G
L
K
E
V
V
E
S
C-
R
G
K
N
L
F
F
S
T
N
I
D
D
A
I
K
E
A
D
--
L
V
F
I
S
V
N
T
P
T
K
T
----
Y
GMGK
G
R
A
-
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
N
S---
N
---
G
Y
K
I
V
T
E
K
S
T
V
P
V
R
A
A
E
S
I
R
R
I
F
DANTKPN---
L
---------
N
L
----------
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
L
I
G
G
D
E
T
--
P
E
-
G
Q
-
R
A
-
V
Q
A
L
C
A
V
Y
E
H
W
V
P
R
--
E
K
I
L
T
T
N
T
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
A
T
A
I
G
M
D
Q
--
R
I
G
N
--
K
F
L
K
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
N
L
V
Y
L
C
EA
L
------
N
--
L
P
EV-
A
R
Y
W
Q
Q
V
I
D
M
N
D
Y
Q
R
R
R
F
A
S
R
I
I
D
S
L
F
N
------------
T
V
T
D
K
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
I
S
K
Y
L
M
D
E
G
A
H
L
H
I
Y
D
P
-----------
K
V
P
R
E
-
Q
I
---
V
VDLSDQVSR-------
L
V
T
I
S
K
D
P
Y
E
A
C
D
G
A
H
A
---
V
V
I
C
T
E
W
D
----
M
F
K
E
L
D
YERIHKKMLKPA-
F
---------
I
-------
F
D
G
R
R
V
L
D
G
-------------------
24
HHSearch
56.40
28%
18
* C1 *
-
2Y0C
5
?
A:
[9-444]
-------
M
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
--
G
--
H
---
D
V
F
C
L
D
V
D
Q
----
A
K
I
D
I
L
N
N
G
G
V
P
I
--
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
--
V
Q
F
I
A
V
G
T
P
P
D
E
----
D
-----
G
S
-
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M---
T
---
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
GGD
Q
---------
M
F
----------
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
--
V
P
-
G
E
-
R
A
-
R
E
L
M
K
K
L
Y
A
P
F
N
R
N
-
H
E
R
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
--
R
I
G
Y
--
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
------
G
--
Q
S
---
L
Q
I
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
A
R
F
G
E
------------
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
-----------
V
A
Q
E
E
-
A
R
---
R
V
I
A
L
D
L
A
DH
P
S
W
L
E
--
R
L
S
F
V
D
D
E
A
Q
A
A
R
D
A
D
A
---
L
V
I
V
T
E
W
K
----
I
F
K
S
P
D
F
V
-----------
A
L
G
R
L
WKTP
V
I
-------
F
D
G
R
N
L
Y
E
P
-------------------
33
HHSearch
56.31
29%
17
- C1 -
-
4A7P
1
?
A:
[9-426]
-------
V
R
I
A
M
I
G
T
G
Y
V
G
L
V
S
G
A
C
F
S
D
F
--
G
--
H
---
E
V
V
C
V
D
K
D
A
----
R
K
I
E
L
L
H
Q
N
V
M
P
I
--
Y
E
P
G
L
D
A
L
V
A
S
N
V
K
A
G
R
L
S
F
T
T
D
L
A
E
G
V
K
D
A
D
--
A
V
F
I
A
V
G
T
P
S
R
R
----
G
----
D
G
H
-
A
D
L
S
Y
V
F
A
A
A
R
E
I
A
E
N
L---
T
---
K
P
S
V
I
V
T
K
S
T
V
P
V
G
T
G
D
E
V
E
R
I
I
A
E
VAPN----
S
---------
G
A
----------
K
V
V
S
N
P
E
F
L
R
E
G
A
A
I
E
D
F
K
R
P
D
R
V
V
V
G
T
E
D
E
--------
F
A
-
R
Q
V
M
R
E
I
Y
R
P
L
S
-----
P
V
L
F
T
G
R
R
T
S
E
L
I
K
Y
A
A
N
A
F
L
A
V
K
I
T
F
I
N
E
I
A
D
L
C
E
Q
V
G
A
D
V
Q
E
V
S
R
G
I
G
M
D
N
--
R
I
-----
F
L
H
A
G
P
G
Y
G
G
S
C
F
P
K
D
T
L
A
L
M
K
T
A
A
D
N
------
E
--
T
P
---
L
R
I
V
E
A
T
V
Q
V
N
D
A
R
K
R
A
M
G
R
K
V
I
K
A
M
G
G
------------
D
V
R
G
K
T
V
G
I
L
G
L
T
F
K
P
N
T
D
D
M
R
D
A
P
S
L
S
I
I
A
A
L
Q
D
A
G
A
T
V
K
A
Y
D
P
-----------
E
G
V
E
Q
A
S
K
M
L-
T
----------------
D
V
E
F
V
E
N
P
Y
A
A
A
D
G
A
D
A
---
L
V
I
V
T
E
W
D
----
A
F
R
A
L
D
L
T
R
I
K
--------
N
S
LKSP
V
---
L
-------
V
D
L
R
N
I
Y
P
--------------------
31
HHSearch
55.06
29%
0
- C- -
-
3GG2
4
?
A:
[3-428]
-------
L
D
I
A
V
V
G
I
G
Y
V
G
L
V
S
A
T
C
F
A
E
L
--
G
--
A
---
N
V
R
C
I
D
T
D
R
----
N
K
I
E
Q
L
N
S
G
T
I
P
I
--
Y
E
P
G
L
E
K
M
I
A
R
N
V
K
A
G
R
L
R
F
G
T
E
I
E
Q
A
V
P
E
A
D
--
I
I
F
I
A
V
G
T
P
A
G
E
----
D
-----
G
S
-
A
D
M
S
Y
V
L
D
A
A
R
S
I
G
R
A
M---
S
---
R
Y
I
L
I
V
T
K
S
T
V
P
V
G
S
Y
R
L
I
R
K
A
I
Q
E
E
L
D
K
R
E
V
L
I
---------
D
F
----------
D
I
A
S
N
P
E
F
L
K
E
G
N
A
I
D
D
F
M
K
P
D
R
V
V
V
G
V
D
S
D
---
R
-----
A
-
R
E
L
I
T
S
L
Y
K
P
M
L
-
L
N
N
F
R
V
L
F
M
D
I
A
S
A
E
M
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
D
V
A
N
L
C
E
R
V
G
A
D
V
S
M
V
R
L
G
I
G
S
D
S
--
R
I
G
S
--
K
F
L
Y
P
G
C
G
Y
G
G
S
C
F
P
K
D
V
K
A
L
I
R
T
A
E
D
N
------
G
--
Y
R
---
M
E
V
L
E
A
V
E
R
V
N
E
K
Q
K
S
I
L
F
D
K
F
S
T
Y
Y
K
G
------------
N
V
Q
G
R
C
V
A
I
W
G
L
S
F
K
P
G
T
D
D
M
R
E
A
P
S
L
V
L
I
E
K
L
L
E
V
G
C
R
V
R
V
Y
D
P
-----------
V
A
M
K
E
A
Q
K
R
--
L
GD--------------
K
V
E
Y
T
T
D
M
Y
D
A
V
R
G
A
E
A
---
L
F
H
V
T
E
W
K
----
E
F
R
M
P
D
W
S
A
L
S
Q
A
MAAS--
L
---------
V
-------
I
D
G
R
N
V
Y
E
L
-------------------
37
HHSearch
54.58
27%
1
- C1 -
-
1MUU
4
ALGD_PSEAE
A:
[1-425]
-------
M
R
I
S
I
F
G
L
G
Y
V
G
A
V
C
A
G
C
L
S
A
R
--
G
--
H
---
E
V
I
G
V
D
V
S
S
----
T
K
I
D
L
I
N
Q
G
K
S
P
I
--
V
E
P
G
L
E
A
L
L
Q
Q
G
R
Q
T
G
R
L
S
G
T
T
D
F
K
K
A
V
L
D
S
D
--
V
S
F
I
C
V
G
T
P
S
K
K
----
N
-----
G
D
-
L
D
L
G
Y
I
E
T
V
C
R
E
I
G
F
A
I
R
EK
S
---
E
R
H
T
V
V
V
R
S
T
V
L
P
G
T
V
N
N
V
V
I
P
L
I
E
D
C
S
GKKAG
V
---------
D
F
----------
G
V
G
T
N
P
E
F
L
R
E
S
T
A
I
K
D
Y
D
F
P
P
M
T
V
I
G
E
L
D
K
--------
Q
T
-
G
D
L
L
E
E
I
Y
R
E
L
D
-
A
---
P
I
I
R
K
T
V
E
V
A
E
M
I
K
Y
T
C
N
V
W
H
A
A
K
V
T
F
A
N
E
I
G
N
I
A
K
A
V
G
V
D
G
R
E
V
M
D
V
I
C
Q
D
H
--
K
L
N
L
SR
Y
Y
M
R
P
G
F
A
F
G
G
S
C
L
P
K
D
V
R
A
L
T
Y
R
A
S
Q
L
------
D
--
V
E
---
H
P
M
L
G
S
L
M
R
S
N
S
N
Q
V
Q
K
A
F
D
L
I
T
S
-----------------
H
D
T
R
K
V
G
L
L
G
L
S
F
K
A
G
T
D
D
L
R
E
S
P
L
V
E
L
A
E
M
L
I
G
K
G
Y
E
L
R
I
F
D
R
-----------
N
V
E
Y
A
-
R
V
---
H
GAN
K
E
Y
I
E
SKI
P
H
V
--
S
S
L
L
V
S
D
L
D
E
V
V
A
S
S
D
V
---
L
V
L
G
N
G
D
E
----
L
F
V
D
L
V
-------------
N
K
TPSG
K
K
--
L
-------
V
D
L
V
G
F
M
P
H
-------------------
36
HHSearch
53.46
27%
1
- C1 -
-
1MV8
7
ALGD_PSEAE
C:
[1-425]
-------
M
R
I
S
I
F
G
L
G
Y
V
G
A
V
C
A
G
C
L
S
A
R--
G
--
H
---
E
V
I
G
V
D
V
S
S
----
T
K
I
D
L
I
N
Q
G
K
S
P
I
--
V
E
P
G
L
E
A
L
L
Q
Q
GR
Q
T
G
R
L
S
G
T
T
D
F
K
K
A
V
L
D
S
D
--
V
S
F
I
C
V
G
T
P
S
K
K
----
N
-----
G
D
-
L
D
L
G
Y
I
E
T
V
C
R
E
I
G
F
A
IREK
S
---
E
R
H
T
V
V
V
R
S
T
V
L
P
G
T
V
N
N
V
V
I
P
L
IEDCSGKKAG
V
---------
D
F
----------
G
V
G
T
N
P
E
F
L
R
E
S
T
A
I
K
D
Y
D
F
P
P
M
T
V
I
G
E
L
D
K
--------
Q
T
-
G
D
L
L
E
E
I
Y
R
E
L
D
-
A
---
P
I
I
R
K
T
V
E
V
A
E
M
I
K
Y
T
C
N
V
W
H
A
A
K
V
T
F
A
N
E
I
G
N
I
A
K
A
V
G
V
D
G
R
E
V
M
D
V
I
C
Q
D
H
--
K
L
N
L
SR
Y
Y
M
R
P
G
F
A
F
G
G
S
C
L
P
K
D
V
R
A
L
T
Y
R
A
SQ
L
------
D
--
V
E
---
H
P
M
L
G
S
L
M
R
S
N
S
N
Q
V
Q
K
A
F
D
L
I
T
S
-----------------
H
D
T
R
K
V
G
L
L
G
L
S
F
K
A
G
T
D
D
L
R
E
S
P
L
V
E
L
A
E
M
L
I
G
K
G
Y
E
L
R
I
F
D
R
-----------
N
V
E
Y
A
-
R
V
---
H
GANKEYIESKIPHV--
S
S
L
L
V
S
D
L
D
E
V
V
A
S
S
D
V
---
L
V
L
G
N
G
D
E
----
L
F
V
D
L
V
-------------
N
KTPSGKK--
L
-------
V
D
L
V
G
F
M
P
H
-------------------
34
HHSearch
53.18
27%
5
- C1 -
-
3VTF
2
?
A:
[22-432]
-------
A
S
L
S
V
L
G
L
G
Y
V
G
V
V
H
A
V
G
F
A
L
L
--
G
--
H
---
R
V
V
G
Y
D
V
N
P
----
S
I
V
E
R
L
R
A
G
R
P
H
I
--
Y
E
P
G
L
E
E
A
L
G
R
A
L
S
S
G
R
L
S
F
A
E
S
A
E
E
A
V
A
A
T
D
--
A
T
F
I
A
V
G
T
P
P
A
P
----
D
-----
G
S
-
A
D
L
R
Y
V
E
A
A
A
R
A
V
G
R
G
I
---
R
A
K
G
R
W
H
L
V
V
V
K
S
T
V
P
P
G
T
T
E
G
L
V
A
R
A
V
A
E
E
AGG---
V
---------
K
F
----------
S
V
A
S
N
P
E
F
L
R
E
G
S
A
L
E
D
F
F
K
P
D
R
I
V
I
G
A
G
D
E
--------
R
A
-
A
S
F
L
L
D
V
Y
K
A
V
D
-
A
---
P
K
L
V
M
K
P
R
E
A
E
L
V
K
Y
A
S
N
V
F
L
A
L
K
I
S
F
A
N
E
V
G
L
L
A
K
R
L
G
V
D
T
Y
R
V
F
E
A
V
G
L
D
K
--
R
I
G
R
--
H
Y
F
G
A
G
L
G
F
G
G
S
C
F
P
K
D
T
L
A
F
I
R
F
G
E
S
L
------
G
--
L
E
---
M
A
I
S
K
A
V
L
R
V
N
E
Y
M
P
R
Y
A
V
Q
L
L
E
E
R
L
G
G
-------------
L
R
G
R
H
V
G
V
L
G
L
A
F
K
P
N
T
D
D
V
R
E
S
R
G
V
E
V
A
R
L
L
L
E
R
G
A
R
V
Y
V
H
D
P
-----------
M
A
M
E
K
A
R
A
V
--
L
GD--------------
S
V
T
Y
V
E
D
P
Q
A
L
L
D
Q
V
E
G
---
V
I
I
A
T
A
W
P
----
Q
Y
E
G
L
D
YRGK---------
V
---------
V
-------
V
D
G
R
Y
V
K
K
A
-------------------
45
Fugue
52.41
25%
14
- C1 -
-
2O3J
4
UGDH_CAEEL
A:
[3-471]
DQVFGKV
S
K
V
V
C
V
G
A
G
Y
V
G
G
P
T
C
A
M
I
A
H
---
K
--
C
PH
I
T
V
T
V
V
D
M
N
T
----
A
K
I
A
E
W
N
S
D
K
L
P
I
--
Y
E
P
G
L
D
E
I
V
F
A
A
-
R
G
R
N
L
F
F
S
S
D
I
P
K
A
I
A
E
A
D
--
L
I
F
I
S
V
N
T
P
T
K
M
YGRG
K
----
G
M
A
-
P
D
L
K
Y
V
E
S
V
S
R
T
I
A
Q
Y
A---
G
---
G
P
K
I
V
V
E
K
S
T
V
P
V
K
A
A
E
S
I
G
C
I
L
----------
R
---------
E
A
QKL
K
F
-----
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
M
K
D
L
A
N
P
D
R
V
L
I
G
G
E
-
S
-
S
P
E
-
G
L
-
Q
A
-
V
A
E
L
V
R
I
Y
E
N
W
V
P
R
N
R
I
--
I
T
T
N
T
W
S
S
E
L
S
K
L
V
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
V
C
E
A
T
G
A
E
I
S
E
V
A
H
A
V
G
Y
D
T
--
R
I
G
S
--
K
F
L
Q
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
S
L
V
Y
L
C
--
E
S
L
NL--
P
--
Q
V
---
A
D
Y
W
Q
G
V
I
N
I
N
N
W
Q
R
R
R
F
A
D
K
I
I
A
E
L
F
------------
N
T
V
T
D
K
K
I
A
I
F
G
F
A
F
K
K
N
T
G
D
T
R
E
S
S
A
I
H
V
I
K
H
L
M
E
E
H
A
K
L
S
V
Y
D
P
KVQ
K
S
Q
M
L
N
D
L
A
S
V
T
S
A
Q
D
---
V
----------------
E
R
L
I
T
V
E
S
D
P
Y
A
A
A
R
G
A
H
A
I
V
V
L
T
E
W
D
E
FVEL
N
Y
S
Q
I
H
-------------
N
---------
D
MQHP
A
A
I
F
D
G
R
L
I
L
D
Q
K
A
L
R
E
I
GFR
T
F
A
I
GTSPDQ
8
PsiBlast_PDB
52.10
29%
9
- C1 -
-
3GG2
4
?
A:
[3-364]
-------
L
D
I
A
V
V
G
I
G
Y
V
G
L
V
S
A
T
C
F
A
E
L
--
G
--
A
---
N
V
R
C
I
D
T
D
R
----
N
K
I
E
Q
L
N
S
G
T
I
P
I
--
Y
E
P
G
L
E
K
M
I
A
R
N
V
K
A
G
R
L
R
F
G
T
E
I
E
Q
A
V
P
E
A
D
II
F
I
A
V
G
T
P
A
G
E
D
G
----
S
----
A
D
M
S
Y
V
L
D
A
A
R
S
I
G
R
A
M
S
R
Y
----------
I
L
I
V
T
K
S
T
V
P
V
G
S
Y
R
L
I
R
K
A
I
----------
Q
---------
E
E
L
D
K
R
E
V
L
I
D
F
D
I
A
S
N
P
E
F
L
K
E
G
N
A
I
D
D
F
M
K
P
D
R
V
V
V
G
V
D
S
D
-
R
A
R
E
L
I
-
T
S
--------
L
Y
K
P
M
L
L
N
N
F
R
V
L
F
M
D
I
A
S
A
E
M
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
D
V
A
N
L
C
E
R
V
G
A
D
V
S
M
V
R
L
G
I
G
S
D
S
--
R
I
G
S
--
K
F
L
Y
P
G
C
G
Y
G
G
S
C
F
P
K
D
V
K
A
L
I
R
T
A
--
E
------
D
N
G
Y
R
---
M
E
V
L
E
A
V
E
R
V
N
E
K
Q
K
S
I
L
F
D
K
------
F
S
T
Y
Y
K
G
N
V
------
Q
G
R
C
V
A
I
W
G
L
S
F
K
P
G
T
D
D
M
R
E
A
P
S
L
V
L
I
E
K
L
L
E
V
G
C
R
V
R
V
Y
D
P
-----------
V
----------------------------------------------------------------------------------------------------------------------------
39
HHSearch
52.09
21%
-8
- C1 -
-
4XR9
2
?
A:
[16-438]
-------
L
K
V
V
I
A
G
A
G
Y
V
G
T
C
L
A
V
T
L
A
G
R
--
G
--
A
---
E
V
V
A
V
D
S
D
P
----
G
T
V
A
D
L
R
A
G
R
C
R
L
--
P
E
P
G
L
A
G
A
V
R
D
L
A
A
T
G
R
L
T
A
S
T
S
-
Y
D
P
V
G
A
A
D
--
V
V
I
V
T
V
G
T
P
T
D
A
----
G
-----
H
E
-
M
V
T
D
Q
L
V
A
A
C
E
Q
I
A
P
R
L---
R
---
A
G
Q
L
V
I
L
K
S
T
V
S
P
G
T
T
R
T
L
V
A
P
L
----------
L
E
SGGLVHER
D
F
----------
G
L
A
F
C
P
E
R
L
A
E
G
V
A
L
A
Q
V
R
T
L
P
V
-
V
V
G
G
C
G
P
--------
R
S
-
A
A
A
A
E
R
F
W
R
S
A
L
G
V
--
D
V
R
Q
V
P
S
A
E
S
A
E
V
V
K
L
A
T
N
W
W
I
D
A
N
V
A
I
A
N
E
L
A
R
Y
C
A
V
L
G
V
D
V
L
D
V
I
G
A
A
N
T
L
P
--
K
G
S
S
MV
N
L
L
L
P
G
V
G
V
G
G
S
C
L
T
K
D
P
W
M
A
W
R
D
G
R
D
R
------
G
--
V
S
---
L
R
T
V
E
T
A
R
A
V
N
D
D
M
P
R
H
T
A
A
V
I
A
D
E
L
V
K
L
---------
G
R
D
R
N
D
T
T
I
A
V
L
G
A
A
F
K
N
D
T
G
D
V
R
N
T
P
V
R
G
V
V
A
A
L
R
D
S
G
F
R
V
R
I
F
D
P
-----------
L
A
D
P
A
-
E
I
V
A
R
F
----------------
G
T
A
P
A
A
S
L
D
E
A
V
S
G
A
G
C
---
L
A
F
L
A
G
H
R
----
Q
F
H
E
L
D
F
G
A
L
A
E
R
VDEP
C
-
L
---------
V
-------
F
D
G
R
M
H
L
P
P
-------------------
35
HHSearch
52.05
24%
17
- C1 -
-
3G79
-
?
B:
[19-455]
-------
K
K
I
G
V
L
G
M
G
Y
V
G
I
P
A
A
V
L
F
A
D
A--
P
CF
E
---
K
V
L
G
F
Q
R
N
S
KSSG
Y
K
I
E
M
L
N
R
G
E
S
P
L
KG
E
E
P
G
L
E
E
L
I
G
K
VV
K
A
G
K
F
E
C
T
P
D
F
-
S
R
I
S
E
L
D
--
A
V
T
L
A
I
Q
T
P
F
A
N
P---
K
----
D
L
E
-
P
D
F
S
A
L
I
D
G
I
R
N
V
G
K
Y
L---
K
---
P
G
M
L
V
V
L
E
S
T
I
T
P
G
T
T
E
G
M
A
K
Q
I
LEEESGLKAG
E
---------
D
F
----------
A
L
A
H
A
P
E
R
V
M
V
G
R
L
L
K
N
I
R
E
H
D
R
I
V
G
G
I
D
E
A
---------
S
-
T
K
R
A
V
E
L
Y
S
P
V
L
T
V
--
G
Q
V
I
P
M
S
A
T
A
A
E
V
T
K
T
A
E
N
T
F
R
D
L
Q
I
A
A
I
N
Q
L
A
L
Y
C
E
A
M
G
I
N
V
Y
D
V
R
T
G
V
D
S
L
K
GE
G
I
T
R
--
A
V
L
W
P
G
A
G
V
G
G
H
C
L
T
K
D
T
Y
H
L
E
R
G
V
--
K
IGRGEL
D
--
Y
P
EGA
D
S
I
Y
V
L
A
R
K
V
N
D
F
M
P
A
H
M
Y
N
L
T
V
A
A
L
E
R
L
---------
G
K
K
M
D
G
S
K
V
A
M
L
G
W
A
F
I
K
D
S
D
D
A
R
N
T
P
S
E
P
Y
R
D
L
C
L
K
A
G
A
S
V
M
V
H
D
P
-----------
Y
V
V
N
Y
-
P
---------------------
G
V
E
I
S
D
N
L
E
E
V
V
R
N
A
D
A
---
I
V
V
L
A
G
H
S
----
A
Y
S
S
L
K
ADWAKKVSAKANP
V
---------
I
-------
I
D
G
R
N
V
I
E
P
-------------------