@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0515: (2017-12-23 )
MSRQTPSLSFEVFPPTPAVGNDNIISALQDMQELAPHFISVTASNNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATDLIELIKERAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDIAGVHLYTMNNADTAKYIHQATHALFNHQSLG
Atome Classification :
(22 SA)
.........10........20........30.......--.40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSRQTPS
L
S
F
E
VFPPTPAVGN
D
N
I
I
S
A
L
Q
D
M
Q
E
L
A
P
H
F
--
I
S
V
TASN
N
K
F
N
I
K
E
T
T
V
R
L
A
D
F
I
QNDLAI
P
T
I
AHL
P
A
I
Y
L
T
K
D
K
V
A
E
T
I
A
D
L
D
K
V
G
V
Q
K
I
L
A
LRGDIIPDVEP
Q
K
D
F
R
Y
A
T
D
L
I
E
L
I
K
ERAPHF
D
I
I
G
A
CYPEGHPDSP
N
Q
I
S
D
I
Q
N
L
K
K
K
V
D
A
G
C
S
S
L
V
T
Q
L
FFDNE
R
F
YDFQD
K
C
I
L
AGIDVPIHAG
I
M
P
IL
N
R
N
Q
A
L
R
L
L
K
T
C
E
NIHL
P
R
K
F
K
A
I
L
D
K
YEH
D
P
E
S
L
R
A
A
G
L
A
Y
A
V
D
Q
I
V
D
L
V
T
QDIA
G
V
H
L
Y
TMNN
A
D
T
A
K
Y
I
H
Q
A
T
H
A
L
FNHQSLG
39
PsiBlast_CBE
92.71
34%
-141
- C7 -
-
2FMO
2
METF_ECOLI
C:
[24-286]
------
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
-
E
-
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
---------
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
V
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
44
PsiBlast_CBE
92.64
34%
-134
- C7 -
-
1B5T
1
METF_ECOLI
B:
[4-266]
------
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
-
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
G
--
S
G
K
P
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
34
PsiBlast_CBE
92.42
34%
-141
- C7 -
-
1ZPT
2
METF_ECOLI
B:
[24-286]
------
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
-
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
---------
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
40
PsiBlast_CBE
92.34
34%
-137
- C7 -
-
2FMO
2
METF_ECOLI
B:
[24-286]
------
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
-
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
-------
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
V
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
32
PsiBlast_CBE
92.20
34%
-137
- C7 -
-
1ZRQ
2
METF_ECOLI
B:
[24-286]
------
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
-
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
-------
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
36
PsiBlast_CBE
92.19
34%
-137
- C7 -
-
1ZP3
2
METF_ECOLI
B:
[24-286]
------
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
-
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
----
G
K
P
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
11
PsiBlast_PDB
91.72
34%
-134
- C7 -
-
1B5T
1
METF_ECOLI
A:
[4-266]
------
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
-
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
G
--
S
G
K
P
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
52
Fugue
91.32
32%
-133
- C7 -
-
1B5T
1
METF_ECOLI
A:
[1-275]
---
G
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
-
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
--
L
P
P
G
S
G
K
P
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
-
A
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
A
-----
46
PsiBlast_CBE
91.32
33%
-142
- C7 -
-
1ZP4
2
METF_ECOLI
B:
[24-286]
------
N
V
S
F
Q
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
-
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
---------
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
12
PsiBlast_PDB
91.24
33%
-146
- C7 -
-
1ZP4
2
METF_ECOLI
A:
[24-286]
------
N
V
S
F
Q
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
--------
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
G
-----
P
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
4
PsiBlast_PDB
91.18
34%
-136
- C7 -
-
3FST
1
METF_ECOLI
A:
[24-286]
------
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
-
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
--------
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
10
PsiBlast_PDB
91.14
34%
-143
- C7 -
-
2FMO
2
METF_ECOLI
A:
[24-286]
------
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
------
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
---------
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
V
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
43
PsiBlast_CBE
90.92
34%
-140
- C7 -
-
1B5T
1
METF_ECOLI
C:
[4-266]
------
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
-
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
---------
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
5
PsiBlast_PDB
90.74
34%
-138
- C7 -
-
1ZP3
2
METF_ECOLI
A:
[24-286]
------
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
-
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
---------
M
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
9
PsiBlast_PDB
90.32
34%
-138
- C7 -
-
2FMN
2
METF_ECOLI
A:
[24-286]
------
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
-
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
-------
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
V
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
38
PsiBlast_CBE
90.24
34%
-138
- C7 -
-
3FSU
2
METF_ECOLI
C:
[24-286]
------
N
V
S
F
Q
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
-
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
---------
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
42
PsiBlast_CBE
90.14
34%
-144
- C7 -
-
2FMN
2
METF_ECOLI
B:
[24-286]
------
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
-
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
-------
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
V
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
33
PsiBlast_CBE
90.14
34%
-140
- C7 -
-
1ZPT
2
METF_ECOLI
C:
[24-286]
------
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
-
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
----------
M
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
35
PsiBlast_CBE
90.00
34%
-137
- C7 -
-
1ZP3
2
METF_ECOLI
C:
[24-286]
------
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
-
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
---------
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
29
PsiBlast_CBE
89.91
34%
-153
- C7 -
-
3FST
1
METF_ECOLI
E:
[24-286]
------
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
----------
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
----------
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
30
PsiBlast_CBE
89.45
34%
-135
- C7 -
-
3FST
2
METF_ECOLI
C:
[24-286]
------
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
-
R
D
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
----------
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
--------------
65
HHSearch
77.54
32%
-13
* C7 *
-
3FST
2
METF_ECOLI
C:
[22-294]
----
Q
I
N
V
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
---
R
T
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
----------
E
M
Y
A
S
D
L
V
T
L
L
K
E
V
-
A
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
D
M
T
-
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
------