@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1247: (2018-01-08 )
MSVREKMLEILEGIDIRFKEPLHSYSYTKVGGEADYLVFPRNRFELARVVKFANQENIPWMVLGNASNIIVRDGGIRGFVILCDKLNNVSVDGYTIEAEAGANLIETTRIALRHSLTGFEFACGIPGSVGGAVFMNAGAYGGEIAHILQSCKVLTKDGEIETLSAKDLAFGYRHSAIQESGAVVLSVKFALAPGTHQVIKQEMDRLTHLRELKQPLEYPSCGSVFKRPVGHFAGQLISEAGLKGYRIGGVEVSEKHAGFMINVADGTAKDYEDLIQSVIEKVKEHSGITLEREVRILGESLSVAKMYAGGFTPCKR
Atome Classification :
(20 SA)
-.........10........20........30........40........50...----.....60........70........80-.......-.90----.---.-......100.......110.......120.......130.......140.....---..150....-...160.......170......---.--180-.-----........190.--------------------.--------.-----.-------------..------.---------------200...-....210...----..--....--220.....------------------..-----------------230----------------------------..----------------.......240-.......---250-.........260.......270.......280.......290.......300.......310....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-M
S
V
R
E
K
M
L
E
I
L
EGID
I
R
FKEPLHSYSYTKVGGEA
D
Y
L
V
FPR
N
R
F
E
L
A
R
V
V
K
F
AN----QENI
P
W
M
V
LGNA
S
N
I
I
V
RDGG
I
R
G
F
V
I
-
L
C
DKLNN-VSV----D---
G
-
Y
T
I
EAEAGA
N
L
I
E
T
T
R
I
A
L
RHSLTG
F
E
F
ACGIPGSVG
G
A
V
F
M
NAGAYG
G
E
I
A
H
I
---
L
Q
S
C
K
VLTK-DG
E
I
E
T
LSA
K
D
L
A
F
G
Y
R
H
S
A
I
Q---E--S---
G
-----
A
V
V
L
S
V
K
F
A
LAP--------------------G--------
T
-----
H
-------------
Q
V
------
I
---------------
K
Q
E
M
D
R
-
L
T
H
L
R
--
E
L
K
----QP--LEYP--S
C
G
S
V
F
K
R
------------------
P
V
-----------------
G
------------------------------
H
F
----------------
A
G
Q
L
I
S
E
AGL-
K
G
Y
R
IG
G
---
V
---
E
VSEKHA
G
F
M
I
N
VADGT
A
K
D
Y
E
D
L
I
Q
S
V
I
E
K
V
K
E
HSG
I
T
L
E
R
E
V
R
I
LGES
L
S
V
A
K
M
YAGGFTPCKR
23
HHSearch
99.39
52%
-135
- C2 -
-
1HSK
1
MURB_STAAU
A:
[18-317]
---
I
Y
Q
A
L
Q
Q
L
I
P
N
E
K
I
K
V
D
E
P
L
K
R
Y
T
Y
T
K
T
G
G
N
A
D
F
Y
I
T
P
T
K
N
E
E
V
Q
A
V
V
K
Y
A
Y
----
Q
N
E
I
P
V
T
Y
L
G
N
G
S
N
I
I
I
R
E
G
G
I
R
G
I
V
I
-
S
L
L
S
L
D
H
-
I
E
V
----
S
---
D
-
D
A
I
I
A
G
S
G
A
A
I
I
D
V
S
R
V
A
R
D
Y
A
L
T
G
L
E
F
A
C
G
I
P
G
S
I
G
G
A
V
Y
M
N
A
G
A
Y
G
G
E
V
K
D
C
---
I
D
Y
A
L
C
V
N
E
-
Q
G
S
L
I
K
L
T
T
K
E
L
E
L
D
Y
R
N
S
I
I
Q
---
K
--
E
---
H
-----
L
V
V
L
E
A
A
F
T
L
A
P
--------------------
G
--------
K
-----
M
-------------
T
E
------
I
---------------
Q
A
K
M
D
D
-
L
T
E
R
R
--
E
S
K
----
Q
P
--
L
E
Y
P
--
S
C
G
S
V
F
Q
R
------------------
P
P
-----------------
G
------------------------------
H
F
----------------
A
G
K
L
I
Q
D
S
N
L
-
Q
G
H
R
I
G
G
---
V
---
E
V
S
T
K
H
A
G
F
M
V
N
V
D
N
G
T
A
T
D
Y
E
N
L
I
H
Y
V
Q
K
T
V
K
E
K
F
G
I
E
L
N
R
E
V
R
I
I
G
E
H
P
K
--------------
1
PsiBlast_PDB
98.96
52%
-138
- C2 -
-
1HSK
1
MURB_STAAU
A:
[17-314]
--
D
I
Y
Q
A
L
Q
Q
L
I
P
N
E
K
I
K
V
D
E
P
L
K
R
Y
T
Y
T
K
T
G
G
N
A
D
F
Y
I
T
P
T
K
N
E
E
V
Q
A
V
V
K
Y
A
Y
----
Q
N
E
I
P
V
T
Y
L
G
N
G
S
N
I
I
I
R
E
G
G
I
R
G
I
V
I
-
S
L
L
S
L
D
H
-
I
E
V
----
S
---
D
-
D
A
I
I
A
G
S
G
A
A
I
I
D
V
S
R
V
A
R
D
Y
A
L
T
G
L
E
F
A
C
G
I
P
G
S
I
G
G
A
V
Y
M
N
A
G
A
Y
G
G
E
V
K
D
C
---
I
D
Y
A
L
C
V
N
E
-
Q
G
S
L
I
K
L
T
T
K
E
L
E
L
D
Y
R
N
S
I
I
Q
---
K
--
E
---
H
-----
L
V
V
L
E
A
A
F
T
L
A
P
--------------------
G
--------
K
-----
M
-------------
T
E
------
I
---------------
Q
A
K
M
D
D
-
L
T
E
R
R
--
E
S
K
----
Q
P
--
L
E
Y
P
--
S
C
G
S
V
F
Q
R
------------------
P
P
-----------------
G
------------------------------
H
F
----------------
A
G
K
L
I
Q
D
S
N
L
-
Q
G
H
R
I
G
G
---
V
---
E
V
S
T
K
H
A
G
F
M
V
N
V
D
N
G
T
A
T
D
Y
E
N
L
I
H
Y
V
Q
K
T
V
K
E
K
F
G
I
E
L
N
R
E
V
R
I
I
G
E
-----------------
2
PsiBlast_PDB
91.47
51%
-123
- C2 -
-
3TX1
3
MURB_LISMO
A:
[35-320]
--------------
I
A
I
K
L
N
E
P
L
S
K
Y
T
Y
T
K
T
G
G
A
A
D
V
F
V
M
P
K
T
I
E
E
A
Q
E
V
V
A
Y
C
H
----
Q
N
K
I
P
L
T
I
L
G
N
G
S
N
L
I
I
K
D
G
G
I
R
G
V
I
L
-
H
L
D
L
L
Q
T
-
I
E
R
----
N
---
N
-
T
Q
I
V
A
M
S
G
A
K
L
I
D
T
A
K
F
A
L
N
E
S
L
S
G
L
E
F
A
C
G
I
P
G
S
I
G
G
A
L
H
M
N
A
G
A
Y
G
G
E
I
S
D
V
---
L
E
A
A
T
V
L
T
Q
-
T
G
E
L
K
K
L
K
R
S
E
L
K
--
Y
R
-
S
T
I
A
---
E
--
K
---
N
-----
Y
I
V
L
D
A
T
F
S
L
A
L
--------------------
E
--------
E
-----
K
-------------
N
L
------
I
---------------
Q
A
K
M
D
E
-
L
T
A
A
R
--
E
A
K
----
Q
P
--
L
E
Y
P
--
S
C
G
S
V
F
K
R
------------------
P
P
-----------------
G
------------------------------
H
F
----------------
A
G
K
L
I
Q
D
S
G
L
-
Q
G
H
I
I
G
G
---
A
---
Q
V
S
L
K
H
A
G
F
I
V
N
I
G
G
A
T
A
T
D
Y
M
N
L
I
A
Y
V
Q
Q
T
V
R
E
K
F
D
V
E
L
E
T
E
V
K
I
I
G
E
-----------------
30
HHSearch
88.70
49%
-67
- C2 -
-
3TX1
3
MURB_LISMO
A:
[25-321]
----
M
N
N
L
Q
T
K
F
P
H
I
A
I
K
L
N
E
P
L
S
K
Y
T
Y
T
K
T
G
G
A
A
D
V
F
V
M
P
K
T
I
E
E
A
Q
E
V
V
A
Y
C
H
----
Q
N
K
I
P
L
T
I
L
G
N
G
S
N
L
I
I
K
D
G
G
I
R
G
V
I
L
-
H
L
D
L
L
Q
T
-
I
E
R
----
N
---
N
-
T
Q
I
V
A
M
S
G
A
K
L
I
D
T
A
K
F
A
L
N
E
S
L
S
G
L
E
F
A
C
G
I
P
G
S
I
G
G
A
L
H
M
N
A
G
A
Y
G
G
E
I
S
D
V
---
L
E
A
A
T
V
L
T
Q
-
T
G
E
L
K
K
L
K
R
S
E
L
K
--
Y
R
-
S
T
I
A
E--
K
------
N
-----
Y
I
V
L
D
A
T
F
S
L
A
L
--------------------
E
--------
E
-----
K
-------------
N
L
------
I
---------------
Q
A
K
M
D
E
-
L
T
A
A
R
--
E
A
K
----
Q
P
--
L
E
Y
P
--
S
C
G
S
V
F
K
R
------------------
P
P
-----------------
G
------------------------------
H
F
----------------
A
G
K
L
I
Q
D
S
G
L
-
Q
G
H
I
I
G
G
---
A
---
Q
V
S
L
K
H
A
G
F
I
V
N
I
G
G
A
T
A
T
D
Y
M
N
L
I
A
Y
V
Q
Q
T
V
R
E
K
F
D
V
E
L
E
T
E
V
K
I
I
G
E
D
----------------
43
Fugue
83.92
51%
14
- C2 -
-
1HSK
1
MURB_STAAU
A:
[15-317]
N
K
D
I
Y
Q
A
L
Q
Q
L
I
P
N
E
K
I
K
V
D
E
P
L
K
R
Y
T
Y
T
K
T
G
G
N
A
D
F
Y
I
T
P
T
K
N
E
E
V
Q
A
V
V
K
Y
A
Y
----
Q
N
E
I
P
V
T
Y
L
G
N
G
S
N
I
I
I
R
E
G
G
I
R
G
I
V
I
-
S
L
L
S
L
D
H
-
I
E
V
----
S
---
D
-
D
A
I
I
A
G
S
G
A
A
I
I
D
V
S
R
V
A
R
D
Y
A
L
T
G
L
E
F
A
C
G
I
P
G
S
I
G
G
A
V
Y
M
N
A
G
A
Y
G
G
E
V
K
D
C
---
I
D
Y
A
L
C
V
N
E
-
Q
G
S
L
I
K
L
T
T
K
E
L
E
L
D
Y
R
N
S
I
I
Q
---
K
--
E
---
H
-----
L
V
V
L
E
A
A
F
T
L
A
P
--------------------
G
--------
K
-----
M
-------------
T
E
------
I
---------------
Q
A
K
M
D
D
-
L
T
E
R
R
--
E
S
K
----
Q
P
--
L
E
Y
P
--
S
C
G
S
V
F
Q
R
------------------
P
P
-----------------
G
------------------------------
H
F
----------------
A
G
K
L
I
Q
D
S
N
L
-
Q
G
H
R
I
G
G
---
V
---
E
V
S
T
K
H
A
G
F
M
V
N
V
D
N
G
T
A
T
D
Y
E
N
L
I
H
Y
V
Q
K
T
V
K
E
K
F
G
I
E
L
N
R
E
V
R
I
I
G
E
H
P
K
--------------
32
HHSearch
75.46
36%
-24
* C2 *
-
4PYT
1
MURB_BACLD
A:
[7-302]
------
E
L
K
D
L
Q
-
V
G
K
V
L
E
N
E
P
L
A
N
H
T
T
I
K
I
G
G
P
A
D
C
L
V
I
P
K
D
I
Q
A
V
R
D
T
M
E
V
V
K
----
N
H
G
V
Q
W
R
A
I
G
R
G
S
N
L
L
V
L
D
E
G
I
R
G
V
V
I
-
K
L
G
A
G
L
D
H
M
E
I
----
D
---
G
-
E
Q
V
T
V
G
G
G
Y
S
V
V
R
L
S
T
G
I
S
K
K
G
L
S
G
L
E
F
A
S
G
I
P
G
S
V
G
G
A
V
Y
M
N
A
G
A
H
G
S
D
I
S
R
I
---
L
V
K
A
L
I
L
F
E
-
D
G
T
M
E
W
L
T
N
E
E
M
E
F
S
Y
R
T
S
I
L
Q
---
N
--
K
R
--
P
-----
G
I
C
L
E
A
V
L
Q
L
E
Q
--------------------
K
--------
E
-----
R
-------------
D
A
------
I
---------------
V
A
Q
M
Q
K
-
N
K
D
Y
R
--
K
E
T
----
Q
P
--
V
S
N
P
--
C
A
G
S
I
F
R
N
------------------
P
L
-----------------
P
------------------------------
D
H
----------------
A
G
R
L
V
E
Q
A
G
L
-
K
G
H
R
I
G
G
---
A
---
K
V
S
E
M
H
G
N
F
I
V
N
A
G
G
A
T
A
K
D
V
L
D
L
I
A
F
I
Q
K
T
I
K
E
K
Y
D
I
D
M
H
T
E
V
E
I
V
G
E
K
----------------
3
PsiBlast_PDB
72.81
37%
-21
- C2 -
-
4PYT
1
MURB_BACLD
A:
[20-301]
--------------------
E
P
L
A
N
H
T
T
I
K
I
G
G
P
A
D
C
L
V
I
P
K
D
I
Q
A
V
R
D
T
M
E
V
V
K
----
N
H
G
V
Q
W
R
A
I
G
R
G
S
N
L
L
V
L
D
E
G
I
R
G
V
V
I
K
L
G
A
G
L
D
H
-
M
E
I
----
D
---
G
-
E
Q
V
T
V
G
G
G
Y
S
V
V
R
L
S
T
G
I
S
K
K
G
L
S
G
L
E
F
A
S
G
I
P
G
S
V
G
G
A
V
Y
M
N
A
G
A
H
G
S
D
I
S
R
I
---
L
V
K
A
L
I
L
F
E
-
D
G
T
M
E
W
L
T
N
E
E
M
E
F
S
Y
R
T
S
I
L
Q
N--
K
--
R
---
P
-----
G
I
C
L
E
A
V
L
Q
L
E
Q
--------------------
K
--------
E
-----
R
-------------
D
A
------
I
---------------
V
A
Q
M
Q
K
-
N
K
D
Y
R
--
K
E
T
----
Q
P
--
V
S
N
P
--
C
A
G
S
I
F
R
N
------------------
P
L
-----------------
P
------------------------------
D
H
----------------
A
G
R
L
V
E
Q
A
G
L
-
K
G
H
R
I
G
G
---
A
---
K
V
S
E
M
H
G
N
F
I
V
N
A
G
G
A
T
A
K
D
V
L
D
L
I
A
F
I
Q
K
T
I
K
E
K
Y
D
I
D
M
H
T
E
V
E
I
V
G
E
-----------------
10
PsiBlast_PDB
72.64
25%
-44
- C2 -
-
1UXY
2
MURB_ECOLI
A:
[3-336]
----------------------
L
K
P
W
N
T
F
G
I
D
H
N
A
Q
H
I
V
C
A
E
D
E
Q
Q
L
L
N
A
W
Q
Y
A
T
----
A
E
G
Q
P
V
L
I
L
G
E
G
S
N
V
L
F
L
E
D
-
Y
R
G
T
V
I
-
I
-
N
R
I
K
G
-
I
E
I
H
D
E
P
D
---
A
-
W
Y
L
H
V
G
A
G
E
N
W
H
R
L
V
K
Y
T
L
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
CA
Y
V
D
S
V
E
L
A
T
---
G
K
Q
V
R
L
T
A
K
E
C
R
F
G
Y
R
D
S
I
F
K
HEY
Q
--
D
---
R
-----
F
A
I
V
A
V
G
L
R
L
P
K
--------------------
E
--------
W
-----
Q
-------------
P
V
------
L
TYGDLTRLDPTTVT
P
Q
Q
V
F
N
A
-
V
C
H
M
R
T
T
K
L
P
----
D
P
--
K
V
N
G
--
N
A
G
A
F
F
K
N
------------------
P
V
V
S
A
E
T
A
K
A
L
L
-------
S
------------------------------
Q
F
PTA
P
N
Y
P
Q
ADG
S
V
K
L
A
A
G
W
L
I
D
Q
C
Q
L
-
K
G
M
Q
I
G
G
---
A
---
A
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
V
R
F
I
G
A
S
G
E
V
S
A
V
----------
26
HHSearch
72.51
29%
-43
- C2 -
-
2MBR
2
MURB_ECOLI
A:
[2-334]
---------------------
S
L
K
P
W
N
T
F
G
I
D
H
N
A
Q
H
I
V
C
A
E
D
E
Q
Q
L
L
N
A
W
Q
Y
A
T
----
A
E
G
Q
P
V
L
I
L
G
E
G
S
N
V
L
F
L
E
D
-
Y
R
G
T
V
I
-
I
N
R
I
-
K
G
-
I
E
I
----
H
D
E
P
D
A
W
Y
L
H
V
G
A
G
E
N
W
H
R
L
V
K
Y
T
L
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
---
C
A
Y
V
D
S
V
E
L
A
T
G
K
Q
V
R
L
T
A
K
E
C
R
F
G
Y
R
D
S
I
F
K
---
H
EY
Q
D--
R
-----
F
A
I
V
A
V
G
L
R
L
P
K
--------------------
E
WQPVLTYG
D
LTRLD
P
-------------
T
T
------
V
T
P
-------------
Q
Q
V
F
N
A
-
V
C
H
M
R
--
T
T
K
----
L
P
DP
K
V
N
G
--
N
A
G
S
F
F
K
N
------------------
P
V
V
S
A
E
T
A
K
A
L
L
S
Q
F
PTA
P
N
Y
P
Q
ADG
S
V
K
---------------------
L
A
----------------
A
G
W
L
I
D
Q
C
Q
L
-
K
G
M
Q
I
G
G
---
A
---
A
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
V
R
F
I
G
A
S
G
E
V
S
------------
29
HHSearch
71.68
31%
-36
- C2 -
-
5JZX
1
MURB_MYCTU
C:
[46-404]
-----------
F
A
G
A
H
I
A
E
A
V
P
L
A
P
L
T
T
L
R
V
G
P
I
A
R
R
V
I
T
C
T
S
A
E
Q
V
V
A
A
L
R
H
L
D
S
A
AK
T
G
A
D
R
P
L
V
F
A
G
G
S
N
L
V
I
A
E
N
L
T
D
L
T
V
V
-
R
L
A
-
N
S
G
-
I
T
I
----
D
---
G
-
N
L
V
R
A
E
A
G
A
V
F
D
D
V
V
V
R
A
I
E
Q
G
L
G
G
L
E
C
L
S
G
I
P
G
S
A
G
A
T
P
V
Q
N
V
G
A
Y
G
A
E
V
S
D
T
---
I
T
R
V
R
L
L
D
R
C
T
G
E
V
R
W
V
S
A
R
D
L
R
F
G
Y
R
T
S
V
L
K
-------A
V
-
P
-----
T
V
V
L
E
V
E
F
A
L
D
P
--------------------
S
G-------
R
SA---
P
LRY----------
G
E
L
-----
I
A
A
L
NATSGERAD---
P
Q
A
V
R
E
A
V
L
A
L
R
--
A
R
K
GMVL
D
P
TD
H
D
T
W
--
S
V
G
S
F
F
T
N
------------------
P
V
-----------------
V
T
Q
D
V
Y
E
R
L
A
G
D
A
A
T
R
KDGPV
P
H
Y
P
A
PDGVK
L
A
----------------
A
G
W
L
V
E
R
A
G
F
G
K
G
Y
P
D
A
G
AAP
C
---
R
L
S
T
K
H
A
L
A
L
T
N
R
G
G
A
T
A
E
D
V
V
T
L
A
R
A
V
R
D
G
V
H
D
V
F
G
I
T
L
K
P
E
P
V
L
I
G
C
M
----------------
25
HHSearch
70.94
27%
-39
- C2 -
-
4JAY
3
MURB_PSEAE
C:
[4-340]
--------------
L
E
L
Q
E
H
C
S
L
K
P
Y
N
T
F
G
I
D
V
R
A
R
L
L
A
H
A
R
D
E
A
D
V
R
E
A
L
A
L
A
R
----
E
R
G
L
P
L
L
V
I
G
G
G
S
N
L
L
L
T
R
-
D
V
E
A
L
V
L
-
R
M
A
S
Q
G
R
R
I
V
S
----
D
AAD
S
-
V
L
V
E
A
E
A
G
E
A
W
D
P
F
V
Q
W
S
L
E
R
G
L
A
G
L
E
N
L
S
L
I
P
G
T
V
G
A
A
P
M
Q
N
I
G
A
Y
G
V
E
L
K
D
V
---
F
D
S
L
T
A
L
D
R
Q
D
G
T
L
R
E
F
D
R
Q
A
C
R
F
G
Y
R
D
S
L
F
K
---
Q
E-
P
D--
R
-----
W
L
I
L
R
V
R
L
R
L
T
R
--------------------
R
--------
E
-----
R
LHLDYGPVRQRLE
E
E
G-----
I
ASPTA----------
R
D
V
S
R
V
-
I
C
A
I
R
--
R
E
K
----
L
P
DP
A
V
L
G
--
N
A
G
S
F
F
K
N
------------------
P
L
-----------------
V
DATQAERLRQAFPDLVGYPQADGRLK----
L
A
----------------
A
G
W
L
I
D
K
G
G
W
-
K
G
F
R
D
G
P
---
V
---
G
V
H
A
Q
Q
A
L
V
L
V
N
H
G
G
A
T
G
A
Q
V
R
A
L
A
E
R
I
Q
E
D
V
R
R
R
F
G
V
E
L
E
P
E
P
N
L
Y
-------------------
24
HHSearch
70.68
27%
-39
- C2 -
-
4JB1
8
MURB_PSEAE
A:
[4-340]
--------------
L
E
L
Q
E
H
C
S
L
K
P
Y
N
T
F
G
I
D
V
R
A
R
L
L
A
H
A
R
D
E
A
D
V
R
E
A
L
A
L
A
R
----
E
R
G
L
P
L
L
V
I
G
G
G
S
N
L
L
L
T
R
-
D
V
E
A
L
V
L
-
R
M
A
S
Q
G
R
R
I
V
S
----
D
AAD
S
-
V
L
V
E
A
E
A
G
E
A
W
D
P
F
V
Q
W
S
L
E
R
G
L
A
G
L
E
N
L
S
L
I
P
G
T
V
G
A
A
P
M
Q
N
I
G
A
Y
G
V
E
L
K
D
V
---
F
D
S
L
T
A
L
D
R
Q
D
G
T
L
R
E
F
D
R
Q
A
C
R
F
G
Y
R
D
S
L
F
K
---
Q
E
-
P
D--
R
-----
W
L
I
L
R
V
R
L
R
L
T
R
--------------------
R
--------
E
-----
R
L
H
LDY
G
P
V
R
Q
R
L
E
E
E
G-----
I
ASPT
A
----------
R
D
V
S
R
V
-
I
C
A
I
R
--
R
E
K
----
L
P
DP
A
V
L
G
--
N
A
G
S
F
F
K
N
------------------
P
L
-----------------
V
D
A
T
Q
A
E
R
L
R
Q
A
F
PD
L
V
G
Y
P
Q
ADGRLK----
L
A
----------------
A
G
W
L
I
D
K
G
G
W
-
K
G
F
R
D
G
P
---
V
---
G
V
H
A
Q
Q
A
L
V
L
V
N
H
G
G
A
T
G
A
Q
V
R
A
L
A
E
R
I
Q
E
D
V
R
R
R
F
G
V
E
L
E
P
E
P
N
L
Y
-------------------
9
PsiBlast_PDB
70.33
25%
-43
- C2 -
-
2MBR
2
MURB_ECOLI
A:
[3-336]
----------------------
L
K
P
W
N
T
F
G
I
D
H
N
A
Q
H
I
V
C
A
E
D
E
Q
Q
L
L
N
A
W
Q
Y
A
T
----
A
E
G
Q
P
V
L
I
L
G
E
G
S
N
V
L
F
L
E
D
-
Y
R
G
T
V
I
-
I
-
N
R
I
K
G
-
I
E
I
H
D
E
P
D
---
A
-
W
Y
L
H
V
G
A
G
E
N
W
H
R
L
V
K
Y
T
L
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
CA
Y
V
D
S
V
E
L
A
T
---
G
K
Q
V
R
L
T
A
K
E
C
R
F
G
Y
R
D
S
I
F
K
HEY
Q
--
D
---
R
-----
F
A
I
V
A
V
G
L
R
L
P
K
--------------------
E
--------
W
-----
Q
-------------
P
V
------
L
TYGDLTRLDPTTVT
P
Q
Q
V
F
N
A
-
V
C
H
M
R
T
T
K
L
P
----
D
P
--
K
V
N
G
--
N
A
G
S
F
F
K
N
------------------
P
V
V
S
A
E
T
A
K
A
L
L
-------
S
------------------------------
Q
F
PTA
P
N
Y
P
Q
ADG
S
V
K
L
A
A
G
W
L
I
D
Q
C
Q
L
-
K
G
M
Q
I
G
G
---
A
---
A
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
V
R
F
I
G
A
S
G
E
V
S
A
V
----------
27
HHSearch
70.28
29%
-48
- C2 -
-
3I99
1
MURB_VIBCH
A:
[10-346]
-------------
T
M
Q
I
Q
L
G
A
N
L
K
P
Y
H
T
F
G
I
E
Q
L
A
A
Q
L
V
V
A
E
S
I
D
D
L
K
A
L
Y
C
S
A
E
----
W
A
S
L
P
K
L
I
I
G
K
G
S
N
M
L
F
T
C
-
H
Y
T
G
M
I
V
-
V
N
R
-
L
N
G
-
I
E
H
----
Q
Q
D
D
D
Y
H
R
L
H
V
A
G
G
E
D
W
P
S
L
V
S
W
C
V
E
Q
G
I
G
G
L
E
N
L
A
L
I
P
G
C
A
G
S
A
P
I
Q
N
I
G
A
Y
G
V
E
F
K
D
V
---
C
D
Y
V
E
Y
L
C
L
E
T
G
T
V
K
R
L
T
M
E
E
C
Q
F
G
Y
R
D
S
I
F
K
---
H
QL
Y
Q--
K
-----
A
V
V
T
A
V
G
L
K
F
A
K
--------------------
A
WQPIIQYG
P
-----
L
-------------
K
D
LSSDCA
I
---------------
H
D
V
Y
Q
R
-
V
C
A
T
R
--
M
E
K
----
L
P
DP
A
V
M
G
--
N
A
G
S
F
F
K
N
------------------
P
V
-----------------
I
S
Q
Q
A
F
A
R
L
Q
I
E
H
PD
V
V
A
Y
P
A
EQ
G
V
K
-----
V
A
----------------
A
G
W
L
I
D
Q
A
G
L
-
K
G
H
Q
I
G
G
---
A
---
K
V
H
P
K
Q
A
L
V
I
V
N
T
G
D
A
S
A
Q
D
V
L
M
L
A
A
D
I
Q
Q
R
V
F
N
C
Y
G
I
E
L
E
H
E
V
R
F
I
G
E
S
E
E
--------------
6
PsiBlast_PDB
70.15
25%
-37
- C2 -
-
2Q85
2
MURB_ECOLI
A:
[5-338]
----------------------
L
K
P
W
N
T
F
G
I
D
H
N
A
Q
H
I
V
C
A
E
D
E
Q
Q
L
L
N
A
W
Q
Y
A
T
----
A
E
G
Q
P
V
L
I
L
G
E
G
S
N
V
L
F
L
E
D
-
Y
R
G
T
V
I
-
I
-
N
R
I
K
G
-
I
E
I
H
D
E
P
D
---
A
-
W
Y
L
H
V
G
A
G
E
N
W
H
R
L
V
K
Y
T
L
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
CA
Y
V
D
S
V
E
L
A
T
---
G
K
Q
V
R
L
T
A
K
E
C
R
F
G
Y
R
D
S
I
F
K
HEY
Q
--
D
---
R
-----
F
A
I
V
A
V
G
L
R
L
P
K
--------------------
E
--------
W
-----
Q
-------------
P
V
------
L
TYGDLTRLDPTTVT
P
Q
Q
V
F
N
A
-
V
C
H
M
R
T
T
K
L
P
----
D
P
--
K
V
N
G
--
N
A
G
S
F
F
K
N
------------------
P
V
V
S
A
E
T
A
K
A
L
L
-------
S
------------------------------
Q
F
PTA
P
N
Y
P
Q
ADG
S
V
K
L
A
A
G
W
L
I
D
Q
C
Q
L
-
K
G
M
Q
I
G
G
---
A
---
A
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
V
R
F
I
G
A
S
G
E
V
S
A
V
----------
31
HHSearch
70.01
36%
-106
- C2 -
-
2GQT
1
MURB_THET8
A:
[5-266]
----------------
R
V
E
R
V
L
L
K
D
Y
T
T
L
G
V
G
G
P
A
E
L
W
-
T
V
E
T
R
E
E
L
K
R
A
T
----------
E
A
P
Y
R
V
L
G
N
G
S
N
L
L
V
L
D
E
G
V
P
E
R
V
I
-
R
L
A
G
-
E
F
-
Q
T
Y
--------
D
-
L
K
G
W
V
G
A
G
T
L
L
P
L
L
V
Q
E
A
A
R
A
G
L
S
G
L
E
G
L
L
G
I
P
A
Q
V
G
G
A
V
K
M
N
A
G
T
R
F
G
E
M
A
D
A
---
L
E
A
V
E
V
F
H
--
D
G
A
F
H
V
Y
C
P
E
E
L
G
F
G
Y
R
K
S
H
L
P
---
P
------
G
-----
G
I
V
T
R
V
R
L
K
L
K
E
--------------------
R
--------
P
-----
K
-------------
E
E
------
I
---------------
L
R
R
M
A
E
-
V
D
R
A
R
---
K
G
----
Q
P
---
K
R
K
--
S
A
G
C
A
F
K
N
------------------
P
P
-----------------
G
------------------------------
Q
S
----------------
A
G
R
L
I
D
E
R
G
L
-
K
G
L
R
V
G
D
---
A
---
M
I
S
L
E
H
G
N
F
I
V
N
L
G
Q
A
R
A
K
D
V
L
E
L
V
R
R
V
Q
E
E
----
L
P
L
E
L
E
W
E
V
----------------------
12
PsiBlast_PDB
69.75
27%
-46
- C2 -
-
5JZX
1
MURB_MYCTU
A:
[100-402]
-----------------------------------------------------------------
L
V
F
A
G
G
S
N
L
V
I
A
E
N
-
L
T
D
L
T
V
-
V
R
L
A
N
S
G
-
I
T
I
----
D
---
G
-
N
L
V
R
A
E
A
G
A
V
F
D
D
V
V
V
R
A
I
E
Q
G
L
G
G
L
E
C
L
S
G
I
P
G
S
A
G
A
T
P
V
Q
N
V
G
A
Y
G
A
E
V
S
D
T
---
I
T
R
V
R
L
L
D
R
C
T
G
E
V
R
W
V
S
A
R
D
L
R
F
G
Y
R
T
S
V
L
K
---
H
--
A
---
D
GLAVP
T
V
V
L
E
V
E
F
A
L
D
P
SGRSAPLRY
G
E
L
I
A
A
L
NATS
G
--------
E
-----
R
-------------
A
D
------
P
---------------
Q
A
V
R
E
A
-
V
L
A
L
R
--
A
R
K
GMVL
D
P
--
T
D
H
D
TW
S
V
G
S
F
F
T
N
P
V
V
T
Q
D
V
Y
E
R
L
A
G
D
A
ATR
P
V
-----------------
P
------------------------------
H
Y
P
A
PDGVKLA-------
A
G
W
L
V
E
R
A
G
F
G
K
G
Y
P
D
A
G
---
A
APC
R
L
S
T
K
H
A
L
A
L
T
N
R
G
G
A
T
A
E
D
V
V
T
L
A
R
A
V
R
D
G
V
H
D
V
F
G
I
T
L
K
P
E
P
V
L
I
G
------------------
28
HHSearch
69.73
31%
-19
- C2 -
-
5JZX
1
MURB_MYCTU
A:
[39-404]
----
R
S
G
V
G
S
L
F
A
G
A
H
I
A
E
A
V
P
L
A
P
L
T
T
L
R
V
G
P
I
A
R
R
V
I
T
C
T
S
A
E
Q
V
V
A
A
L
R
H
L
D
S
A
AK
T
G
A
D
R
P
L
V
F
A
G
G
S
N
L
V
I
A
E
N
L
T
D
L
T
V
V
-
R
L
A
-
N
S
G
-
I
T
I
----
D
---
G
-
N
L
V
R
A
E
A
G
A
V
F
D
D
V
V
V
R
A
I
E
Q
G
L
G
G
L
E
C
L
S
G
I
P
G
S
A
G
A
T
P
V
Q
N
V
G
A
Y
G
A
E
V
S
D
T
---
I
T
R
V
R
L
L
D
R
C
T
G
E
V
R
W
V
S
A
R
D
L
R
F
G
Y
R
T
S
V
L
K
---
H
AD
G
LAV
P
-----
T
V
V
L
E
V
E
F
A
L
D
P
--------------------
S
G-------
R
SA---
P
LRY----------
G
E
L
-----
I
A
A
L
NATSGERAD---
P
Q
A
V
R
E
A
V
L
A
L
R
--
A
R
K
GMVL
D
P
TD
H
D
T
W
--
S
V
G
S
F
F
T
N
------------------
P
V
-----------------
V
T
Q
D
V
Y
E
R
L
A
G
D
A
ATRP
V
P
H
Y
P
A
PDGVK---
L
A
----------------
A
G
W
L
V
E
R
A
G
F
G
K
G
Y
P
D
A
G
AAP
C
---
R
L
S
T
K
H
A
L
A
L
T
N
R
G
G
A
T
A
E
D
V
V
T
L
A
R
A
V
R
D
G
V
H
D
V
F
G
I
T
L
K
P
E
P
V
L
I
G
C
M
----------------
7
PsiBlast_PDB
68.31
25%
-39
- C2 -
-
1MBB
2
MURB_ECOLI
A:
[5-338]
----------------------
L
K
P
W
N
T
F
G
I
D
H
N
A
Q
H
I
V
C
A
E
D
E
Q
Q
L
L
N
A
W
Q
Y
A
T
----
A
E
G
Q
P
V
L
I
L
G
E
G
S
N
V
L
F
L
E
D
-
Y
R
G
T
V
I
-
I
-
N
R
I
K
G
-
I
E
I
H
D
E
P
D
---
A
-
W
Y
L
H
V
G
A
G
E
N
W
H
R
L
V
K
Y
T
L
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
CA
Y
V
D
S
V
E
L
A
T
---
G
K
Q
V
R
L
T
A
K
E
C
R
F
G
Y
R
D
S
I
F
K
HEY
Q
--
D
---
R
-----
F
A
I
V
A
V
G
L
R
L
P
K
--------------------
E
--------
W
-----
Q
-------------
P
V
------
L
TYGDLTRLDPTTVT
P
Q
Q
V
F
N
A
-
V
C
H
M
R
T
T
K
L
P
----
D
P
--
K
V
N
G
--
N
A
G
S
F
F
K
N
------------------
P
V
V
S
A
E
T
A
K
A
L
L
-------
S
------------------------------
Q
F
PT
A
P
N
Y
P
Q
ADG
S
V
K
L
A
A
G
W
L
I
D
Q
C
Q
L
-
K
G
M
Q
I
G
G
---
A
---
A
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
V
R
F
I
G
A
S
G
E
V
S
A
V
----------
8
PsiBlast_PDB
68.02
25%
-35
- C2 -
-
1MBT
1
MURB_ECOLI
A:
[5-338]
----------------------
L
K
P
W
N
T
F
G
I
D
H
N
A
Q
H
I
V
C
A
E
D
E
Q
Q
L
L
N
A
W
Q
Y
A
T
----
A
E
G
Q
P
V
L
I
L
G
E
G
S
N
V
L
F
L
E
D
-
Y
R
G
T
V
I
-
I
-
N
R
I
K
G
-
I
E
I
H
D
E
P
D
---
A
-
W
Y
L
H
V
G
A
G
E
N
W
H
R
L
V
K
Y
T
L
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
CA
Y
V
D
S
V
E
L
A
T
---
G
K
Q
V
R
L
T
A
K
E
C
R
F
G
Y
R
D
S
I
F
K
HEY
Q
--
D
---
R
-----
F
A
I
V
A
V
G
L
R
L
P
K
--------------------
E
--------
W
-----
Q
-------------
P
V
------
L
TYGDLTRLDPTTVT
P
Q
Q
V
F
N
A
-
V
C
H
M
R
T
T
K
L
P
----
D
P
--
K
V
N
G
--
N
A
G
S
F
F
K
N
------------------
P
V
V
S
A
E
T
A
K
A
L
L
-------
S
------------------------------
Q
F
PTAP
N
Y
P
Q
ADG
S
V
K
L
A
A
G
W
L
I
D
Q
C
Q
L
-
K
G
M
Q
I
G
G
---
A
---
A
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
V
R
F
I
G
A
S
G
E
V
S
A
V
----------