@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1440: (2018-01-12 )
MKFNELNLSADLLAEIEKAGFVEASPIQEQTIPLALEGKDVIGQAQTGTGKTAAFGLPTLEKIRTEEATIQALVIAPTRELAVQSQEELFRFGRSKGVKVRSVYGGSSIEKQIKALKSGAHIVVGTPGRLLDLIKRKALKLQDIETLILDEADEMLNMGFLEDIEAIISRVPENRQTLLFSATMPDAIKRIGVQFMKAPEHVKIAAKELTTELVDQYYIRVKEQEKFDTMTRLMDVAQPELAIVFGRTKRRVDELTRGLKIRGFRAEGIHGDLDQNKRLRVLRDFKNGNLDVLVATDVAARGLDISGVTHVYNYDIPQDPESYVHRIGRTGRAGKSGQSITFVAPNEMGYLQIIENLTKKRMKGLKPASVEESFQSKKQVALKKIERDFADETIRANFEKFGKDARKLAAEFTPEELAMYILSLTVQDPDSLPEVEIAREKPLPFKPSGNGFGGKAKGGRGGRRGDDRRERDRRGNGRRDEFKKGSRGNDRFDKEKRYRKDNKKPRNTLSEKQTGFVIRNKGDK
Atome Classification :
(62 SA)
.........10........20........30..--...--.--.--.40........50........60..-------------------.-.----..------------------.---.----70-------.........80........-----90...------.-.----...100.....-..110....-...120-........130..-..--.-..140........150....---.-..160......-------.170.----.----.-------.--.-....180.......190.......200.....----.----.--210--.........220.-.-.-.-..-.----.----230...-.-...240-------........250.......260--.---.....----..270.......280.......290.......300.......310.....------.------.320.......330.......340.-....-..350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKFNELNL
S
A
D
L
L
A
E
I
E
KAGFVEASPIQEQT
I
P
--
L
A
L--E--G--KDVIGQAQTGTGKTAAFGL
P
T
L
E
K
I
-------------------R-T----EE------------------
A
---
T
----
I
--------
Q
A
L
V
IAP
T
R
E
L
A
VQ
S
Q
E
E
L
-----
F
R
FGR------S-K----G
V
K
V
R
S
VYGG
S
-
S
I
E
K
Q
I
K
A
L
-KSG
A
-
H
-
I
V
VGT
P
G
R
L
L
D
L
I
-
K
R
--
K
-
A
L
K
L
-
Q
D
I
E
T
L
I
LD
E
A
D
E
M
L
---
N
-
M
G
F
L
E
D
I
E
A
I
I
-------
S
R--V----P----E-------N--R-
Q
T
L
L
F
SAT
M
P
D
A
I
K
R
I
G
V
Q
F
MKAP
E
H
V
K
I
A
A
K
----
E
----
L
--
T
----
T
E
L
V
D
Q
Y
Y
I
R
V-K-
E
-
Q
-
E
-
K
F
-
D
----
T
----
M
T
R
L
M
D
-V-AQP
E
L
--------
A
I
V
FGR
T
K
R
R
V
D
E
L
TRG
L
K
I
---
R
---
G
F
R
AE----GIHGDLDQ
N
K
R
L
R
V
L
R
D
FKNG
N
L
D
V
L
V
ATDVAARGLDISG
V
T
H
V
Y
NYDIP------Q------D
P
E
S
Y
V
H
R
IGRTGRAGKSG
Q
S
I
T
F
V-APNE-M
G
Y
L
Q
I
I
E
N
L
T
K
K
R
M
KGLKP
A
S
V
E
E
S
F
Q
S
K
K
Q
V
A
L
K
K
I
E
R
D
FA
D
E
T
I
R
A
N
F
E
K
F
G
K
D
A
R
K
L
A
A
EF
T
P
E
E
L
A
M
Y
I
L
S
L
T
VQDPDSLPEVEIAREKPLPFKPSGNGFGGKAKGGRGGRRGD
D
R
R
E
R
DRRGNGR
R
D
E
FKKGSRGNDR
F
D
K
E
K
R
Y
RKDNKKPRNTLSEKQT
G
F
V
IRNKGDK
137
HHSearch
86.81
58%
-95
- C1 -
-
5IVL
-
?
B:
[4-423]
--
F
Q
E
L
G
L
S
Q
E
V
M
K
A
I
E
R
M
G
F
E
E
T
T
P
I
Q
A
K
T
I
P
--
L
S
L
--
Q
--
N
--
K
D
V
I
G
Q
A
Q
T
G
T
G
K
T
A
A
F
G
I
P
I
V
E
K
V
-------------------
D
-
V
----
K
N
------------------
G
---
A
----
I
--------
Q
A
L
V
V
A
P
T
R
E
L
A
I
Q
V
S
E
E
L
-----
Y
K
I
G
A
------
V
-
K
----
R
V
R
V
L
P
I
Y
G
G
Q
-
D
I
E
R
Q
I
R
A
L
-
K
K
H
P
-
H
-
V
I
V
G
T
P
G
R
I
I
D
H
I
-
N
R
--
G
-
T
L
R
L
-
E
H
V
H
T
V
V
L
D
E
A
D
E
M
L
------
G
F
I
E
D
I
E
A
I
L
-------
S
H
--
V
----
P
----
A
-------
E
--
R
-
Q
T
L
L
F
S
A
T
M
P
D
P
I
R
R
I
A
E
R
F
M
N
E
P
E
L
V
K
V
K
A
------------------
V
P
N
I
Q
Q
Y
Y
L
E
V
-
H
-
E
-
K
-
K
-
K
F
-
D
----
I
----
L
T
R
L
L
D
-
I
-
Q
A
P
E
L
--------
A
I
V
F
G
R
T
K
R
R
V
D
E
L
A
E
A
L
N
L
---
R
---
G
Y
A
A
E
----
G
I
H
G
D
L
S
Q
A
K
R
L
S
V
L
R
K
F
K
E
G
A
I
E
I
L
V
A
T
D
V
A
A
R
G
L
D
I
S
G
V
T
H
V
Y
N
F
D
I
P
------
Q
------
D
P
E
S
Y
V
H
R
I
G
R
T
G
R
A
G
K
T
G
V
A
M
T
F
V
-
T
P
R
E
-
I
G
Q
L
H
H
I
E
R
T
T
K
R
K
M
E
R
M
K
P
P
T
L
D
E
A
L
E
G
Q
Q
R
I
A
I
E
K
L
L
N
V
V
E
T
----
E
---
F
Y
K
R
A
A
E
E
L
L
E
E
H
D
S
V
T
I
V
A
A
C
L
K
M
L
E
--------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.71
62%
-93
- C1 -
-
5IVL
-
?
B:
[4-389]
--
F
Q
E
L
G
L
S
Q
E
V
M
K
A
I
E
R
M
G
F
E
E
T
T
P
I
Q
A
K
T
I
P
--
L
S
L
--
Q
--
N
--
K
D
V
I
G
Q
A
Q
T
G
T
G
K
T
A
A
F
G
I
P
I
V
E
K
V
-------------------
D
-
V
----
K
N
------------------
G
---
A
----
I
--------
Q
A
L
V
V
A
P
T
R
E
L
A
I
Q
V
S
E
E
L
-----
Y
K
I
G
A
------
V
-
K
----
R
V
R
V
L
P
I
Y
G
G
Q
-
D
I
E
R
Q
I
R
A
L
-
K
K
H
P
-
H
-
V
I
V
G
T
P
G
R
I
I
D
H
I
-
N
R
--
G
-
T
L
R
L
-
E
H
V
H
T
V
V
L
D
E
A
D
E
M
L
------
G
F
I
E
D
I
E
A
I
L
-------
S
H
--
V
----
P
----
A
-------
E
--
R
-
Q
T
L
L
F
S
A
T
M
P
D
P
I
R
R
I
A
E
R
F
M
N
E
P
E
L
V
K
V
K
A
------------------
V
P
N
I
Q
Q
Y
Y
L
E
V
-
H
-
E
-
K
-
K
-
K
F
-
D
----
I
----
L
T
R
L
L
D
-
I
-
Q
A
P
E
L
--------
A
I
V
F
G
R
T
K
R
R
V
D
E
L
A
E
A
L
N
L
---
R
---
G
Y
A
A
E
----
G
I
H
G
D
L
S
Q
A
K
R
L
S
V
L
R
K
F
K
E
G
A
I
E
I
L
V
A
T
D
V
A
A
R
G
L
D
I
S
G
V
T
H
V
Y
N
F
D
I
P
------
Q
------
D
P
E
S
Y
V
H
R
I
G
R
T
G
R
A
G
K
T
G
V
A
M
T
F
V
-
T
P
R
E
-
I
G
Q
L
H
H
I
E
R
T
T
K
R
K
M
E
R
M
K
P
P
T
L
D
E
A
L
E
G
Q
Q
R
I
A
I
E
K
L
-------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
75.63
38%
-127
- C1 -
-
1S2M
-
DHH1_YEAST
A:
[48-417]
--
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
--
V
A
I
--
T
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
-------------------
K
-
P
----
K
L
------------------
N
---
K
----
I
--------
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
-----
R
T
L
G
K
------
H
-
C
----
G
I
S
C
M
V
T
T
G
G
T
-
N
L
R
D
D
I
L
R
L
-
N
E
T
V
-
H
-
I
L
V
G
T
P
G
R
V
L
D
L
A
-
S
R
--
K
-
V
A
D
L
-
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
---
S
-
R
D
F
K
T
I
I
E
Q
I
L
-------
S
F
--
L
----
P
----
P
-------
T
--
H
-
Q
S
L
L
F
S
A
T
F
P
L
T
V
K
E
F
M
V
K
H
L
H
K
P
Y
E
I
N
L
-
M
E
----
E
----
L
--
T
----
L
K
G
I
T
Q
Y
Y
A
F
V
-
E
-
E
-
R
-
Q
-
K
L
-
H
----
C
----
L
N
T
L
F
S
-
K
-
L
Q
I
N
Q
--------
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
---
L
---
G
Y
S
C
Y
----
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
------
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
-
N
W
N
D
-
R
F
N
L
Y
K
I
E
Q
E
L
G
T
E
I
A
A
I
-
P
A
T
I
D
K
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.06
41%
-77
- C1 -
-
2J0Q
2
IF4A3_HUMAN
A:
[39-392]
--
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
--
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
-------------------
D
-
I
----
Q
V
------------------
R
---
E
----
T
--------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
-----
L
A
L
G
D
------
Y
-
M
----
N
V
Q
C
H
A
C
I
G
G
T
-
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
-
H
-
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
R
--
R
-
S
L
R
T
-
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
-------
R
Y
--
L
----
P
----
P
-------
A
--
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
----
E
----
L
--
T
----
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
F
-
D
----
T
----
L
C
D
L
Y
D
-
T
-
L
T
I
T
Q
--------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
---
A
---
N
F
T
V
S
----
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
-
I
R
I
L
R
D
I
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
73.93
41%
-77
- C1 -
-
2XB2
1
IF4A3_HUMAN
X:
[40-393]
--
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
--
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
-------------------
D
-
I
----
Q
V
------------------
R
---
E
----
T
--------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
-----
L
A
L
G
D
------
Y
-
M
----
N
V
Q
C
H
A
C
I
G
G
T
-
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
-
H
-
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
R
--
R
-
S
L
R
T
-
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
-------
R
Y
--
L
----
P
----
P
-------
A
--
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
----
E
----
L
--
T
----
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
F
-
D
----
T
----
L
C
D
L
Y
D
-
T
-
L
T
I
T
Q
--------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
---
A
---
N
F
T
V
S
----
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
-
I
R
I
L
R
D
I
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.90
37%
-127
- C1 -
-
4BRW
2
DHH1_YEAST
A:
[3-372]
--
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
--
V
A
I
--
T
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
-------------------
K
-
P
----
K
L
------------------
N
---
K
----
I
--------
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
-----
R
T
L
G
K
------
H
-
C
----
G
I
S
C
M
V
T
T
G
G
T
-
N
L
R
D
D
I
L
R
L
-
N
E
T
V
-
H
-
I
L
V
G
T
P
G
R
V
L
D
L
A
-
S
R
--
K
-
V
A
D
L
-
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
---
S
-
R
D
F
K
T
I
I
E
Q
I
L
-------
S
F
--
L
----
P
----
P
-------
T
--
H
-
Q
S
L
L
F
S
A
T
F
P
L
T
V
D
E
F
M
D
K
H
L
H
K
P
Y
E
I
N
L
-
M
E
----
E
----
L
--
T
----
L
K
G
I
T
Q
Y
Y
A
F
V
-
E
-
E
-
R
-
Q
-
K
L
-
H
----
C
----
L
N
T
L
F
S
-
K
-
L
Q
I
N
Q
--------
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
---
L
---
G
Y
S
C
Y
----
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
------
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
-
N
W
N
D
-
R
F
N
L
Y
K
I
E
Q
E
L
G
T
E
I
A
A
I
-
P
A
T
I
D
K
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.81
41%
-78
- C1 -
-
2HYI
2
IF4A3_HUMAN
C:
[40-393]
--
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
--
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
-------------------
D
-
I
----
Q
V
------------------
R
---
E
----
T
--------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
-----
L
A
L
G
D
------
Y
-
M
----
N
V
Q
C
H
A
C
I
G
G
T
-
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
-
H
-
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
R
--
R
-
S
L
R
T
-
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
-------
R
Y
--
L
----
P
----
P
-------
A
--
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
----
E
----
L
--
T
----
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
F
-
D
----
T
----
L
C
D
L
Y
D
-
T
-
L
T
I
T
Q
--------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
---
A
---
N
F
T
V
S
----
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
-
I
R
I
L
R
D
I
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.61
41%
-81
- C1 -
-
3EX7
3
IF4A3_HUMAN
C:
[40-393]
--
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
--
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
-------------------
D
-
I
----
Q
V
------------------
R
---
E
----
T
--------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
-----
L
A
L
G
D
------
Y
-
M
----
N
V
Q
C
H
A
C
I
G
G
T
-
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
-
H
-
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
R
--
R
-
S
L
R
T
-
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
-------
R
Y
--
L
----
P
----
P
-------
A
--
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
----
E
----
L
--
T
----
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
F
-
D
----
T
----
L
C
D
L
Y
D
-
T
-
L
T
I
T
Q
--------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
---
A
---
N
F
T
V
S
----
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
-
I
R
I
L
R
D
I
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
73.36
41%
-75
- C1 -
-
3EX7
3
IF4A3_HUMAN
H:
[40-393]
--
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
--
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
-------------------
D
-
I
----
Q
V
------------------
R
---
E
----
T
--------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
-----
L
A
L
G
D
------
Y
-
M
----
N
V
Q
C
H
A
C
I
G
G
T
-
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
-
H
-
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
R
--
R
-
S
L
R
T
-
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
-------
R
Y
--
L
----
P
----
P
-------
A
--
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
----
E
----
L
--
T
----
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
F
-
D
----
T
----
L
C
D
L
Y
D
-
T
-
L
T
I
T
Q
--------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
---
A
---
N
F
T
V
S
----
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
-
I
R
I
L
R
D
I
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
73.30
37%
-124
- C1 -
-
4BRU
-
DHH1_YEAST
A:
[48-417]
--
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
--
V
A
I
--
T
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
-------------------
K
-
P
----
K
L
------------------
N
---
K
----
I
--------
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
-----
R
T
L
G
K
------
H
-
C
----
G
I
S
C
M
V
T
T
G
G
T
-
N
L
R
D
D
I
L
R
L
-
N
E
T
V
-
H
-
I
L
V
G
T
P
G
R
V
L
D
L
A
-
S
R
--
K
-
V
A
D
L
-
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
---
S
-
R
D
F
K
T
I
I
E
Q
I
L
-------
S
F
--
L
----
P
----
P
-------
T
--
H
-
Q
S
L
L
F
S
A
T
F
P
L
T
V
D
E
F
M
D
K
H
L
H
K
P
Y
E
I
N
L
-
M
E
----
E
----
L
--
T
----
L
K
G
I
T
Q
Y
Y
A
F
V
-
E
-
E
-
R
-
Q
-
K
L
-
H
----
C
----
L
N
T
L
F
S
-
K
-
L
Q
I
N
Q
--------
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
---
L
---
G
Y
S
C
Y
----
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
------
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
-
N
W
N
D
-
R
F
N
L
Y
K
I
E
Q
E
L
G
T
E
I
A
A
I
-
P
A
T
I
D
K
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
73.22
41%
-75
- C1 -
-
2HYI
2
IF4A3_HUMAN
I:
[40-393]
--
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
--
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
-------------------
D
-
I
----
Q
V
------------------
R
---
E
----
T
--------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
-----
L
A
L
G
D
------
Y
-
M
----
N
V
Q
C
H
A
C
I
G
G
T
-
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
-
H
-
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
R
--
R
-
S
L
R
T
-
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
-------
R
Y
--
L
----
P
----
P
-------
A
--
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
----
E
----
L
--
T
----
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
F
-
D
----
T
----
L
C
D
L
Y
D
-
T
-
L
T
I
T
Q
--------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
---
A
---
N
F
T
V
S
----
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
-
I
R
I
L
R
D
I
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.14
41%
-78
- C1 -
-
2J0S
2
IF4A3_HUMAN
A:
[39-392]
--
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
--
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
-------------------
D
-
I
----
Q
V
------------------
R
---
E
----
T
--------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
-----
L
A
L
G
D
------
Y
-
M
----
N
V
Q
C
H
A
C
I
G
G
T
-
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
-
H
-
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
R
--
R
-
S
L
R
T
-
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
-------
R
Y
--
L
----
P
----
P
-------
A
--
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
----
E
----
L
--
T
----
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
F
-
D
----
T
----
L
C
D
L
Y
D
-
T
-
L
T
I
T
Q
--------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
---
A
---
N
F
T
V
S
----
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
-
I
R
I
L
R
D
I
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.09
41%
-76
- C1 -
-
2XB2
1
IF4A3_HUMAN
A:
[40-393]
--
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
--
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
-------------------
D
-
I
----
Q
V
------------------
R
---
E
----
T
--------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
-----
L
A
L
G
D
------
Y
-
M
----
N
V
Q
C
H
A
C
I
G
G
T
-
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
-
H
-
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
R
--
R
-
S
L
R
T
-
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
-------
R
Y
--
L
----
P
----
P
-------
A
--
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
----
E
----
L
--
T
----
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
F
-
D
----
T
----
L
C
D
L
Y
D
-
T
-
L
T
I
T
Q
--------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
---
A
---
N
F
T
V
S
----
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
-
I
R
I
L
R
D
I
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
72.97
41%
-77
- C1 -
-
2J0Q
2
IF4A3_HUMAN
B:
[39-392]
--
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
--
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
-------------------
D
-
I
----
Q
V
------------------
R
---
E
----
T
--------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
-----
L
A
L
G
D
------
Y
-
M
----
N
V
Q
C
H
A
C
I
G
G
T
-
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
-
H
-
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
R
--
R
-
S
L
R
T
-
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
-------
R
Y
--
L
----
P
----
P
-------
A
--
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
----
E
----
L
--
T
----
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
-
E
-
W
-
K
F
-
D
----
T
----
L
C
D
L
Y
D
-
T
-
L
T
I
T
Q
--------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
---
A
---
N
F
T
V
S
----
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
-
I
R
I
L
R
D
I
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
HHSearch
72.71
39%
-123
- C1 -
-
1S2M
-
DHH1_YEAST
A:
[46-407]
N
T
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
--
V
A
I
--
T
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
-------------------
K
-
P
----
K
L
------------------
N
---
K
----
I
--------
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
-----
R
T
L
G
K
------
H
-
C
----
G
I
S
C
M
V
T
T
G
G
T
-
N
L
R
D
D
I
L
R
L
-
N
E
T
V
-
H
-
I
L
V
G
T
P
G
R
V
L
D
L
A
-
S
R
--
K
-
V
A
D
L
-
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
---
S
-
R
D
F
K
T
I
I
E
Q
I
L
-------
S
F
--
L
----
P
----
P
-------
T
--
H
-
Q
S
L
L
F
S
A
T
F
P
L
T
V
K
E
F
M
V
K
H
L
H
K
P
Y
E
I
N
L
M
E
-----
E
----
L
--
T
----
L
K
G
I
T
Q
Y
Y
A
F
V
-
E
-
E
-
R
-
Q
-
K
L
-
H
----
C
----
L
N
T
L
F
S
-
K
-
L
Q
I
N
Q
--------
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
---
L
---
G
Y
S
C
Y
----
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
------
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
-
N
W
N
D
-
R
F
N
L
Y
K
I
E
Q
E
L
G
T
E
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
70.03
39%
-83
- C1 -
-
2VSX
1
IF4A_YEAST
B:
[23-386]
-
K
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
--
P
I
I
--
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
-------------------
D
-
T
----
S
V
------------------
K
---
A
----
P
--------
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
-----
M
A
L
A
F
------
H
-
M
----
D
I
K
V
H
A
C
I
G
-----------
L
-
R
D
-
A
-
Q
-
I
V
V
G
T
P
G
R
V
F
D
N
I
-
Q
R
--
R
-
R
F
R
T
-
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
---
S
-
S
G
F
K
E
Q
I
Y
Q
I
F
-------
T
L
--
L
----
P
----
P
-------
T
--
T
-
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
----
E
----
L
--
T
----
L
E
G
I
K
Q
F
Y
V
N
V
-
E
-
E
-
E
-
E
Y
K
Y
-
E
----
C
----
L
T
D
L
Y
D
-
S
-
I
S
V
T
Q
--------
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
---
D
---
K
F
T
V
S
----
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
-
T
N
E
D
-
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
70.00
39%
-83
- C1 -
-
2VSX
1
IF4A_YEAST
A:
[23-386]
-
K
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
--
P
I
I
--
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
-------------------
D
-
T
----
S
V
------------------
K
---
A
----
P
--------
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
-----
M
A
L
A
F
------
H
-
M
----
D
I
K
V
H
A
C
I
G
-----------
L
-
R
D
-
A
-
Q
-
I
V
V
G
T
P
G
R
V
F
D
N
I
-
Q
R
--
R
-
R
F
R
T
-
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
---
S
-
S
G
F
K
E
Q
I
Y
Q
I
F
-------
T
L
--
L
----
P
----
P
-------
T
--
T
-
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
----
E
----
L
--
T
----
L
E
G
I
K
Q
F
Y
V
N
V
-
E
-
E
-
E
-
E
Y
K
Y
-
E
----
C
----
L
T
D
L
Y
D
-
S
-
I
S
V
T
Q
--------
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
---
D
---
K
F
T
V
S
----
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
-
T
N
E
D
-
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
69.98
39%
-85
- C1 -
-
2VSO
1
IF4A_YEAST
A:
[23-386]
-
K
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
--
P
I
I
--
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
-------------------
D
-
T
----
S
V
------------------
K
---
A
----
P
--------
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
-----
M
A
L
A
F
------
H
-
M
----
D
I
K
V
H
A
C
I
G
-----------
L
-
R
D
-
A
-
Q
-
I
V
V
G
T
P
G
R
V
F
D
N
I
-
Q
R
--
R
-
R
F
R
T
-
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
---
S
-
S
G
F
K
E
Q
I
Y
Q
I
F
-------
T
L
--
L
----
P
----
P
-------
T
--
T
-
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
----
E
----
L
--
T
----
L
E
G
I
K
Q
F
Y
V
N
V
-
E
-
E
-
E
-
E
Y
K
Y
-
E
----
C
----
L
T
D
L
Y
D
-
S
-
I
S
V
T
Q
--------
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
---
D
---
K
F
T
V
S
----
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
-
T
N
E
D
-
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
150
HHSearch
69.76
40%
-75
- C1 -
-
2J0U
-
IF4A3_HUMAN
A:
[2-362]
-
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
--
Q
I
I
--
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
V
S
V
L
Q
C
L
-------------------
D
-
I
----
Q
V
------------------
R
---
E
----
T
--------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
V
Q
K
G
L
-----
L
A
L
G
D
------
Y
-
M
----
N
V
Q
C
H
A
C
I
G
G
T
-
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
-
H
-
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
R
--
R
-
S
L
R
T
-
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
-------
R
Y
--
L
----
P
----
P
-------
A
--
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
----
E
----
L
--
T
----
L
E
G
I
K
Q
F
F
V
A
V
-
E
R
E
-
E
-
W
-
K
F
-
D
----
T
----
L
C
D
L
Y
D
-----
I
T
Q
--------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
---
A
---
N
F
T
V
S
----
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
--
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
V
N
F
V
-
K
N
D
D
-
I
R
V
L
R
D
I
E
Q
Y
Y
S
T
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
69.73
39%
-85
- C1 -
-
2VSO
1
IF4A_YEAST
B:
[23-386]
-
K
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
--
P
I
I
--
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
-------------------
D
-
T
----
S
V
------------------
K
---
A
----
P
--------
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
-----
M
A
L
A
F
------
H
-
M
----
D
I
K
V
H
A
C
I
G
-----------
L
-
R
D
-
A
-
Q
-
I
V
V
G
T
P
G
R
V
F
D
N
I
-
Q
R
--
R
-
R
F
R
T
-
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
---
S
-
S
G
F
K
E
Q
I
Y
Q
I
F
-------
T
L
--
L
----
P
----
P
-------
T
--
T
-
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
----
E
----
L
--
T
----
L
E
G
I
K
Q
F
Y
V
N
V
-
E
-
E
-
E
-
E
Y
K
Y
-
E
----
C
----
L
T
D
L
Y
D
-
S
-
I
S
V
T
Q
--------
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
---
D
---
K
F
T
V
S
----
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
-
T
N
E
D
-
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
68.84
43%
-11
- C1 -
-
4KBF
1
?
A:
[1-362]
M
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
--
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
-------------------
A
-
P
----
S
Q
------------------
E
RGR
K
----
P
--------
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
-----
T
A
V
--------
A
-
P
----
H
L
K
V
V
A
V
Y
G
G
T
-
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
-
D
-
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
Q
--
G
-
V
L
D
L
-
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
-
M
G
F
E
E
E
V
E
A
L
L
-------
S
A
--
T
----
P
----
P
-------
S
--
R
-
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
D
----
E
----
P
--
V
----
T
--
Y
E
E
E
A
V
P
A
-
P
-
V
-
R
-
G
-
R
L
-
E
----
V
----
L
S
D
L
L
Y
-
V
-
A
S
P
D
R
--------
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
---
L
---
G
H
P
A
Q
----
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
------
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
-
G
P
R
E
-
R
R
D
V
E
A
L
E
R
A
V
G
R
R
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
67.15
39%
-11
- C1 -
-
4PXA
1
DDX3X_HUMAN
A:
[67-429]
--
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
--
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
DGPG
E
A
L
R
A
M
K
E
NGRYG
R
-
R
----
K
Q
------------------
Y
---
P
----
I
---------
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
-----
R
K
F
S
Y
------
R
-
S
----
R
V
R
P
C
V
V
Y
G
G
A
-
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
-
H
-
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
R
--
G
-
K
I
G
L
-
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
V
-
M
G
F
E
P
Q
I
R
R
I
V
-------
E
Q
DT
M
----
P
----
P
-------
K
GV
R
-
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
--
E
Y
I
F
L
A
V
G
----
R
----
V
GS
T
----
S
E
N
I
T
Q
K
V
V
W
V
-
E
-
E
-
S
-
D
-
K
R
-
S
----
F
----
L
L
D
L
L
N
A
T
-
G
K
D
S
L
--------
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
---
E
---
G
Y
A
C
T
----
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
66.98
36%
-5
- C1 -
-
4D26
2
?
A:
[51-419]
-
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
--
I
I
M
--
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
-------------------
L
-
Q
----
D
P
K
D
L
I
S
E
NG
C
---------
A
---
Q
----
P
--------
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
-----
R
K
F
S
Y
------
G
-
S
----
V
L
K
V
A
V
A
Y
G
G
T
-
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
-
H
-
I
L
V
A
T
P
G
R
L
H
D
F
V
-
E
R
--
N
-
R
V
S
F
-
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
---
D
-
M
G
F
M
P
S
I
E
K
M
M
-------
L
H
--
P
----
T
MVET
T
-------
K
--
R
-
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
----
G
----
G
--
A
----
S
T
D
V
E
Q
I
F
I
E
V
-
T
-
K
-
Y
-
E
-
K
R
-
N
----
S
----
L
K
Q
L
I
E
-
E
-
N
D
G
K
R
--------
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
---
Q
---
Q
L
L
T
S
----
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
------
K
------
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
-
D
S
D
Q
---
D
L
A
L
V
A
D
L
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
66.68
36%
1
- C1 -
-
4D25
3
?
A:
[51-419]
-
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
--
I
I
M
--
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
-------------------
L
-
Q
----
D
P
KD
L
I
S
E
NG
C
---------
A
---
Q
----
P
--------
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
-----
R
K
F
S
Y
------
G
-
S
----
V
L
K
V
A
V
A
Y
G
G
T
-
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
-
H
-
I
L
V
A
T
P
G
R
L
H
D
F
V
-
E
R
--
N
-
R
V
S
F
-
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
---
D
-
M
G
F
M
P
S
I
E
K
M
M
-------
L
H
--
P
----
T
MVET
T
-------
K
--
R
-
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
----
G
----
G
--
A
----
S
T
D
V
E
Q
I
F
I
E
V
-
T
-
K
-
Y
-
E
-
K
R
-
N
----
S
----
L
K
Q
L
I
E
-
E
-
N
D
G
K
R
--------
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
---
Q
---
Q
L
L
T
S
----
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
------
K
------
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
-
D
S
D
Q
---
D
L
A
L
V
A
D
L
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
HHSearch
66.12
38%
-4
- C1 -
-
4D26
2
?
A:
[51-409]
-
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
--
I
I
M
--
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
-------------------
L
-
Q
----
D
P
K
D
L
I
S
E
NG
C
---------
A
---
Q
----
P
--------
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
-----
R
K
F
S
Y
------
G
-
S
----
V
L
K
V
A
V
A
Y
G
G
T
-
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
-
H
-
I
L
V
A
T
P
G
R
L
H
D
F
V
-
E
R
--
N
-
R
V
S
F
-
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
---
D
-
M
G
F
M
P
S
I
E
K
M
M
-------
L
H
--
P
TMVE
T
----
T
-------
K
--
R
-
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
----
G
----
G
--
A
----
S
T
D
V
E
Q
I
F
I
E
V
-
T
-
K
-
Y
-
E
-
K
R
-
N
----
S
----
L
K
Q
L
I
E
-
E
-
N
D
G
K
R
--------
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
---
Q
---
Q
L
L
T
S
----
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
------
K
------
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
-
D
S
D
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
HHSearch
65.59
38%
2
- C1 -
-
4D25
3
?
A:
[51-409]
-
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
--
I
I
M
--
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
-------------------
L
-
Q
----
D
P
KD
L
I
S
E
NG
C
---------
A
---
Q
----
P
--------
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
-----
R
K
F
S
Y
------
G
-
S
----
V
L
K
V
A
V
A
Y
G
G
T
-
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
-
H
-
I
L
V
A
T
P
G
R
L
H
D
F
V
-
E
R
--
N
-
R
V
S
F
-
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
---
D
-
M
G
F
M
P
S
I
E
K
M
M
-------
L
H
--
P
TMVE
T
----
T
-------
K
--
R
-
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
----
G
----
G
--
A
----
S
T
D
V
E
Q
I
F
I
E
V
-
T
-
K
-
Y
-
E
-
K
R
-
N
----
S
----
L
K
Q
L
I
E
-
E
-
N
D
G
K
R
--------
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
---
Q
---
Q
L
L
T
S
----
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
------
K
------
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
-
D
S
D
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
64.14
37%
-33
- C1 -
-
1XTI
4
DX39B_HUMAN
A:
[10-355]
--
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
--
Q
A
I
--
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
L
-------------------
E
-
P
----
V
T
------------------
G
---
Q
----
V
--------
S
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
-----
E
R
F
S
K
------
Y
-
M
P---
N
V
K
V
A
V
F
F
G
G
L
-
S
I
K
K
D
E
E
V
L
-
K
K
N
C
P
H
-
I
V
V
G
T
P
G
R
I
L
A
L
A
-
R
N
--
K
-
S
L
N
L
-
K
H
I
K
H
F
I
L
D
E
C
D
K
M
L
E--
Q
-
L
D
M
R
R
D
V
Q
E
I
F
-------
R
M
--
T
----
P
----
H
-------
E
--
K
-
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
F
V
D
D
E
T---
K
----
L
--
T
----
L
H
G
L
Q
Q
Y
Y
V
K
L
-
K
-
D
-
N
-
E
-
K
N
-
R
----
K
----
L
F
D
L
L
D
-
V
-
L
E
F
N
Q
--------
V
V
I
F
V
K
S
V
Q
R
C
I
A
L
A
Q
L
L
V
E
---
Q
---
N
F
P
A
I
----
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
------
E
------
D
S
D
T
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
F
V
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
63.56
39%
5
- C1 -
-
2I4I
1
DDX3X_HUMAN
A:
[17-379]
--
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
--
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
DGPG
E
A
L
R
A
M
K
E
NGRYG
R
-
R
----
K
Q
------------------
Y
---
P
----
I
---------
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
-----
R
K
F
S
Y
------
R
-
S
----
R
V
R
P
C
V
V
Y
G
G
A
-
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
-
H
-
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
R
--
G
-
K
I
G
L
-
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
-
M
G
F
E
P
Q
I
R
R
I
V
-------
E
Q
DT
M
----
P
----
P
-------
K
GV
R
-
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
--
E
Y
I
F
L
A
V
G
------------
T
----
S
E
N
I
T
Q
K
V
V
W
V
-
E
-
E
-
S
-
D
-
K
R
-
S
----
F
----
L
L
D
L
L
N
A
T
-
G
K
D
S
L
--------
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
---
E
---
G
Y
A
C
T
----
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
HHSearch
63.16
39%
14
- C1 -
-
2I4I
1
DDX3X_HUMAN
A:
[16-395]
-
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
--
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
-------------------
Y
-
S
----
D
G
PG
E
A
L
R
A
M
K
E
NGRYGRR
K
Q
---
Y
----
P
--------
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
-----
R
K
F
S
Y
------
R
-
S
----
R
V
R
P
C
V
V
Y
G
G
A
-
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
-
H
-
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
R
--
G
-
K
I
G
L
-
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
-
M
G
F
E
P
Q
I
R
R
I
V
-------
E
Q
--
D
----
T
MPPK
G
-------
V
--
R
-
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
--------------
T
----
S
E
N
I
T
Q
K
V
V
W
V
-
E
-
E
-
S
-
D
-
K
R
-
S
----
F
----
L
L
D
L
L
N
-
A
T
G
K
D
S
L
--------
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
---
E
---
G
Y
A
C
T
----
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
-
N
E
R
N
-
I
N
I
T
K
D
L
L
D
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
62.85
39%
17
- C1 -
-
5E7J
1
DDX3X_HUMAN
A:
[50-412]
--
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
--
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
GPG
E
A
L
R
A
M
K-------------
K
Q
------------------
Y
---
P
----
I
---------
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
-----
R
K
F
S
Y
------
R
-
S
----
R
V
R
P
C
V
V
Y
G
G
A
-
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
-
H
-
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
R
--
G
-
K
I
G
L
-
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
-
M
G
F
E
P
Q
I
R
R
I
V
-------
E
Q
DT
M
----
P
----
P
-------
K
GV
R
-
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
--
E
Y
I
F
L
A
V
G
----
R
----
V
GS
T
----
S
E
N
I
T
Q
K
V
V
W
V
-
E
-
E
-
S
-
D
-
K
R
-
S
----
F
----
L
L
D
L
L
N
A
T
-
G
K
D
S
L
--------
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
---
E
---
G
Y
A
C
T
----
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
62.57
39%
22
- C1 -
-
5E7M
1
DDX3X_HUMAN
A:
[50-412]
--
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
--
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
GPG
E
A
L
R
A
M
K------
R
-
R
----
K
Q
------------------
Y
---
P
----
I
---------
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
-----
R
K
F
S
Y
------
R
-
S
----
R
V
R
P
C
V
V
Y
G
G
A
-
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
-
H
-
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
R
--
G
-
K
I
G
L
-
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
-
M
G
F
E
P
Q
I
R
R
I
V
-------
E
Q
DT
M
----
P
----
P
-------
K
GV
R
-
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
--
E
Y
I
F
L
A
V
G
----
R
----
V
GS
T
----
S
E
N
I
T
Q
K
V
V
W
V
-
E
-
E
-
S
-
D
-
K
R
-
S
----
F
----
L
L
D
L
L
N
A
T
-
G
K
D
S
L
--------
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
---
E
---
G
Y
A
C
T
----
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
61.24
38%
25
- C1 -
-
3PEY
3
DBP5_YEAST
A:
[7-353]
--
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
--
L
L
L
--
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
-------------------
N
-
P
----
E
D
------------------
A
---
S
----
P
--------
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
-----
Q
E
M
G
K
------
F
-
T
----
K
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
------
N
A
-
Q
-
V
I
V
G
T
P
G
T
V
L
D
L
M
-
R
R
--
K
-
L
M
Q
L
-
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
---
D
-
Q
Q
G
L
G
D
Q
C
I
R
V
-------
K
R
F
-
L
----
P
----
K
-------
D
--
T
-
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
----
E
----
V
--
N
----
V
D
A
I
K
Q
L
Y
M
D
C
-
K
N
E
-
A
-
D
-
K
F
-
D
----
V
----
L
T
E
L
Y
G
-
L
-
M
T
I
G
S
--------
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
---
E
---
G
H
E
V
S
----
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
------
T
LANGQA
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
61.20
38%
27
- C1 -
-
3PEW
2
DBP5_YEAST
A:
[7-353]
--
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
--
L
L
L
--
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
-------------------
N
-
P
----
E
D
------------------
A
---
S
----
P
--------
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
-----
Q
E
M
G
K
------
F
-
T
----
K
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
------
N
A
-
Q
-
V
I
V
G
T
P
G
T
V
L
D
L
M
-
R
R
--
K
-
L
M
Q
L
-
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
---
D
-
Q
Q
G
L
G
D
Q
C
I
R
V
-------
K
R
F
-
L
----
P
----
K
-------
D
--
T
-
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
----
E
----
V
--
N
----
V
D
A
I
K
Q
L
Y
M
D
C
-
K
N
E
-
A
-
D
-
K
F
-
D
----
V
----
L
T
E
L
Y
G
-
V
-
M
T
I
G
S
--------
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
---
E
---
G
H
E
V
S
----
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
------
T
LANGQA
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
HHSearch
58.59
35%
35
- C1 -
-
3G0H
3
DD19B_HUMAN
A:
[42-413]
-
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
--
L
M
L
--
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
-------------------
E
-
P
----
A
N
------------------
K
---
Y
----
P
--------
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
-----
E
Q
M
G
K
------
F
-
Y
P---
E
L
K
L
A
Y
A
V
R
G
N
-
K
L
E
---
R
G
Q
-
K
I
S
E
-
Q
-
I
V
I
G
T
P
G
T
V
L
D
W
C
-
S
K
L-
K
-
F
I
D
P
-
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
---
A
T
Q
G
H
Q
D
Q
S
I
R
I
Q
-------
R
M
--
L
----
P
----
R
-------
N
--
C
-
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
----
E
----
E
--
T
----
L
D
T
I
K
Q
Y
Y
V
L
C
-
S
S
R
-
D
-
E
-
K
F
-
Q
----
A
----
L
C
N
L
Y
G
-
A
-
I
T
I
A
Q
--------
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
---
E
---
G
H
Q
V
A
----
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
VDKDGN
P
------
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
-
D
S
K
H
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
57.26
33%
35
- C1 -
-
3FHT
5
DD19B_HUMAN
B:
[27-400]
--
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
--
L
M
L
--
A
EP
P
--
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
-------------------
E
-
P
----
A
N
------------------
K
---
Y
----
P
--------
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
-----
E
Q
M
G
K
F-----
Y
-
P
----
E
L
K
L
A
Y
A
V
R
G
N
-----------
K
I
S
E
-
Q
-
I
V
I
G
T
P
G
T
V
L
D
W
C
S
K
L
--
K
-
F
I
D
P
-
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
---
A
-
T
Q
G
H
Q
D
Q
S
I
R
I
-------
Q
R
M
-
L
----
P
----
R
-------
N
--
C
-
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
----
E
----
E
--
T
----
L
D
T
I
K
Q
Y
Y
V
L
C
-
S
-
S
-
R
D
E
-
K
F
-
Q
----
A
----
L
C
N
L
Y
G
-
A
-
I
T
I
A
Q
--------
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
---
E
---
G
H
Q
V
A
----
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
VDKDGN
P
------
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
S
-
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
57.18
33%
33
* C1 *
-
3FHT
3
DD19B_HUMAN
A:
[27-399]
--
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
--
L
M
L
--
A
EP
P
--
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
-------------------
E
-
P
----
A
N
------------------
K
---
Y
----
P
--------
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
-----
E
Q
M
G
K
F-----
Y
-
P
----
E
L
K
L
A
Y
A
V
R
G
N
-
K
L
E
R
---
G
Q
-
K
I
S
E
-
Q
-
I
V
I
G
T
P
G
T
V
L
D
W
C
S
K
L
--
K
-
F
I
D
P
-
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
---
A
-
T
Q
G
H
Q
D
Q
S
I
R
I
-------
Q
R
M
-
L
----
P
----
R
-------
N
--
C
-
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
----
E
----
E
--
T
----
L
D
T
I
K
Q
Y
Y
V
L
C
-
S
-
S
-
R
D
E
-
K
F
-
Q
----
A
----
L
C
N
L
Y
G
-
A
-
I
T
I
A
Q
--------
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
---
E
---
G
H
Q
V
A
----
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
VDKDGN
P
------
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
S
-
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
56.35
33%
34
- C1 -
-
3G0H
3
DD19B_HUMAN
A:
[43-416]
--
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
--
L
M
L
--
A
EP
P
--
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
-------------------
E
-
P
----
A
N
------------------
K
---
Y
----
P
--------
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
-----
E
Q
M
G
K
F-----
Y
-
P
----
E
L
K
L
A
Y
A
V
R
G
N
-
K
L
E
R
---
G
Q
-
K
I
S
E
-
Q
-
I
V
I
G
T
P
G
T
V
L
D
W
C
S
K
L
--
K
-
F
I
D
P
-
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
---
A
-
T
Q
G
H
Q
D
Q
S
I
R
I
-------
Q
R
M
-
L
----
P
----
R
-------
N
--
C
-
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
----
E
----
E
--
T
----
L
D
T
I
K
Q
Y
Y
V
L
C
-
S
-
S
-
R
D
E
-
K
F
-
Q
----
A
----
L
C
N
L
Y
G
-
A
-
I
T
I
A
Q
--------
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
---
E
---
G
H
Q
V
A
----
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
VDKDGN
P
------
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
S
-
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
55.76
33%
41
- C1 -
-
3EWS
1
DD19B_HUMAN
A:
[64-442]
--
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
--
L
M
L
--
A
EP
P
--
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
-------------------
E
-
P
----
A
N
------------------
K
---
Y
----
P
--------
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
-----
E
Q
M
G
K
F-----
Y
-
P
----
E
L
K
L
A
Y
A
V
R
G
N
-
K
L
E
R
---
G
Q
-
K
I
S
E
-
Q
-
I
V
I
G
T
P
G
T
V
L
D
W
C
S
K
L
--
K
-
F
I
D
P
-
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
---
A
-
T
Q
G
H
Q
D
Q
S
I
R
I
-------
Q
R
M
-
L
----
P
----
R
-------
N
--
C
-
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
----
E
----
E
--
T
----
L
D
T
I
K
Q
Y
Y
V
L
C
-
S
-
S
-
R
D
E
-
K
F
-
Q
----
A
----
L
C
N
L
Y
G
-
A
-
I
T
I
A
Q
--------
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
---
E
---
G
H
Q
V
A
----
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
D
KDGN
P
------
D
N
E
T
Y
L
H
R
I
G
R
----
G
K
R
G
L
A
V
N
M
V
D
S
K
H
S
-
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
D
T
D
D
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
140
HHSearch
52.74
31%
24
- C1 -
-
3I5X
2
MS116_YEAST
A:
[75-459]
---
E
E
G
V
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
--
P
I
L
--
S
SE
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
-------------------
I
-
N
----
T
K
FDSQ--------------
Y
---
M
----
V
--------
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
-----
K
K
I
H
D
------
M
-
N
YGLK
K
Y
A
C
V
S
L
V
G
G
T
-
D
F
R
A
A
M
N
K
M
N
K
L
R
P
-
N
-
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
K
--
Y
S
N
K
F
F
-
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
-
I
G
F
R
D
D
L
E
T
I
S
-------
G
I
--
L
----
N
----
E
K
NSKSAD
N
--
I
-
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
DKNE
P
----
E
--
A
----
H
E
R
I
D
Q
S
V
V
I
S
-
E
-
K
F
A
-
N
-
S
I
-
F
A
A
V
E
H
----
I
K
K
Q
I
K
E
R
-
D
S
N
Y
K
--------
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
FK
K
---
D
L
P
I
L
----
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
K
D
E
-
L
P
F
V
R
E
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
HHSearch
52.72
31%
25
- C1 -
-
3SQW
2
MS116_YEAST
A:
[27-408]
------
V
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
--
P
I
L
--
S
SE
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
-------------------
I
-
N
----
T
K
FDSQ--------------
Y
---
M
----
V
--------
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
-----
K
K
I
H
D
------
M
-
N
YGLK
K
Y
A
C
V
S
L
V
G
G
T
-
D
F
R
A
A
M
N
K
M
N
K
L
R
P
-
N
-
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
K
--
Y
S
N
K
F
F
-
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
-
I
G
F
R
D
D
L
E
T
I
S
-------
G
I
--
L
----
N
----
E
K
NSKSAD
N
--
I
-
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
----
D
KNEP
E
--
A
----
H
E
R
I
D
Q
S
V
V
I
S
-
E
-
K
F
A
-
N
-
S
I
-
F
----
A
A
V
E
H
I
K
K
Q
I
K
E
R
-
D
S
N
Y
K
--------
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
---
E
FKK
D
L
P
I
L
----
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
K
D
E
-
L
P
F
V
R
E
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
HHSearch
52.21
31%
24
- C1 -
-
4TYN
2
MS116_YEAST
A:
[25-406]
------
V
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
--
P
I
L
--
S
SE
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
-------------------
I
-
N
----
T
K
FDSQ--------------
Y
---
M
----
V
--------
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
-----
K
K
I
H
D
------
M
-
N
YGLK
K
Y
A
C
V
S
L
V
G
G
T
-
D
F
R
A
A
M
N
K
M
N
K
L
R
P
-
N
-
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
K
--
Y
S
N
K
F
F
-
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
-
I
G
F
R
D
D
L
E
T
I
S
-------
G
I
--
L
----
N
----
E
K
NSKSAD
N
--
I
-
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
DKNE
P
----
E
--
A
----
H
E
R
I
D
Q
S
V
V
I
S
-
E
-
K
F
A
-
N
-
S
I
-
F
----
A
A
V
E
H
I
K
K
Q
I
K
E
R
-
D
S
N
Y
K
--------
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
FK
K
---
D
L
P
I
L
----
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
K
D
E
-
L
P
F
V
R
E
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
51.56
46%
-40
- C1 -
-
2GXQ
2
?
A:
[1-205]
M
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
--
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
-------------------
A
-
P
----
S
Q
------------------
E
RGR
K
----
P
--------
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
-----
T
A
V
--------
A
-
P
----
H
L
K
V
V
A
V
Y
G
G
T
-
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
-
D
-
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
Q
--
G
-
V
L
D
L
-
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
-
M
G
F
E
E
E
V
E
A
L
L
-------
S
A
--
T
----
P
----
P
-------
S
--
R
-
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
51.07
46%
-34
- C1 -
-
2GXS
1
?
A:
[1-205]
M
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
--
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
-------------------
A
-
P
----
S
Q
------------------
E
RGR
K
----
P
--------
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
-----
T
A
V
--------
A
-
P
----
H
L
K
V
V
A
V
Y
G
G
T
-
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
-
D
-
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
Q
--
G
-
V
L
D
L
-
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
-
M
G
F
E
E
E
V
E
A
L
L
-------
S
A
--
T
----
P
----
P
-------
S
--
R
-
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
49.71
52%
-50
- C1 -
-
5GJU
1
?
A:
[3-205]
--
F
A
D
L
G
L
K
A
P
I
L
E
A
L
N
D
L
G
Y
E
K
P
S
P
I
Q
A
E
C
I
P
--
H
L
L
--
N
--
G
--
R
D
V
L
G
M
A
Q
T
G
S
G
K
T
A
A
F
S
L
P
L
L
Q
N
L
-------------------
D
-
P
----
E
L
------------------
K
---
A
----
P
--------
Q
I
L
V
L
A
P
T
R
E
L
A
V
Q
V
A
E
A
M
-----
T
D
F
S
K
------
H
M
R
----
G
V
N
V
V
A
L
Y
-------
V
Q
L
R
A
L
-
R
Q
G
P
-
Q
-
I
V
V
G
T
P
G
R
L
L
D
H
L
-
K
R
--
G
-
T
L
D
L
-
S
K
L
S
G
L
V
L
D
E
A
D
E
M
L
---
R
-
M
G
F
I
E
D
V
E
T
I
M
-------
A
Q
--
I
----
P
----
E
-------
G
--
H
-
Q
T
A
L
F
S
A
T
M
P
E
A
I
R
R
I
T
R
R
F
M
K
E
P
Q
E
V
R
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
49.45
31%
53
- C1 -
-
3SQX
2
MS116_YEAST
A:
[28-408]
-------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
S
--
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
-------------------
I
-
N
T
KFD
S
Q
------------------
Y
---
M
----
V
--------
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
G
L
------
K
-
K
----
Y
A
C
V
-
S
L
V
G
G
T
-
D
F
R
A
A
M
N
K
M
N
K
L
R
P
-
N
-
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
K
--
Y
-
S
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
-
I
G
F
R
D
D
L
E
T
I
S
G
I
L
N
E
K
N
S
K
--
S
----
A
----
D
-------
N
--
I
-
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
----
D
----
K
--
N
EPEA
H
E
R
I
D
Q
---
S
V
-
V
-
I
-
S
-
E
-
K
F
A
N
----
S
----
I
F
A
A
V
E
-
H
-
I
K
K
Q
I
K
E
R
D
SN
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
----
N
---
E
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
K
D
E
-
L
P
F
V
R
E
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
49.44
31%
52
- C1 -
-
3I61
2
MS116_YEAST
A:
[79-459]
-------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
S
--
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
-------------------
I
-
N
T
KFD
S
Q
------------------
Y
---
M
----
V
--------
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
G
L
------
K
-
K
----
Y
A
C
V
-
S
L
V
G
G
T
-
D
F
R
A
A
M
N
K
M
N
K
L
R
P
-
N
-
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
K
--
Y
-
S
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
-
I
G
F
R
D
D
L
E
T
I
S
G
I
L
N
E
K
N
S
K
--
S
----
A
----
D
-------
N
--
I
-
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
----
D
----
K
--
N
EPEA
H
E
R
I
D
Q
---
S
V
-
V
-
I
-
S
-
E
-
K
F
A
N
----
S
----
I
F
A
A
V
E
-
H
-
I
K
K
Q
I
K
E
R
D
SN
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
----
N
---
E
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
K
D
E
-
L
P
F
V
R
E
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
49.34
31%
52
- C1 -
-
3I62
2
MS116_YEAST
A:
[79-459]
-------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
S
--
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
-------------------
I
-
N
T
KFD
S
Q
------------------
Y
---
M
----
V
--------
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
G
L
------
K
-
K
----
Y
A
C
V
-
S
L
V
G
G
T
-
D
F
R
A
A
M
N
K
M
N
K
L
R
P
-
N
-
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
K
--
Y
-
S
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
-
I
G
F
R
D
D
L
E
T
I
S
G
I
L
N
E
K
N
S
K
--
S
----
A
----
D
-------
N
--
I
-
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
----
D
----
K
--
N
EPEA
H
E
R
I
D
Q
---
S
V
-
V
-
I
-
S
-
E
-
K
F
A
N
----
S
----
I
F
A
A
V
E
-
H
-
I
K
K
Q
I
K
E
R
D
SN
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
----
N
---
E
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
K
D
E
-
L
P
F
V
R
E
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
49.32
31%
52
- C1 -
-
3SQW
2
MS116_YEAST
A:
[28-408]
-------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
S
--
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
-------------------
I
-
N
T
KFD
S
Q
------------------
Y
---
M
----
V
--------
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
G
L
------
K
-
K
----
Y
A
C
V
-
S
L
V
G
G
T
-
D
F
R
A
A
M
N
K
M
N
K
L
R
P
-
N
-
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
K
--
Y
-
S
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
-
I
G
F
R
D
D
L
E
T
I
S
G
I
L
N
E
K
N
S
K
--
S
----
A
----
D
-------
N
--
I
-
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
----
D
----
K
--
N
EPEA
H
E
R
I
D
Q
---
S
V
-
V
-
I
-
S
-
E
-
K
F
A
N
----
S
----
I
F
A
A
V
E
-
H
-
I
K
K
Q
I
K
E
R
D
SN
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
----
N
---
E
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
K
D
E
-
L
P
F
V
R
E
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
49.14
31%
52
- C1 -
-
4TYN
2
MS116_YEAST
A:
[26-406]
-------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
PI
L
S
S
--
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
-------------------
I
-
N
T
K
FD
S
Q
------------------
Y
---
M
----
V
--------
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
G
L
------
K
-
K
----
Y
A
C
V
-
S
L
V
G
G
T
-
D
F
R
A
A
M
N
K
M
N
K
L
R
P
-
N
-
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
K
--
Y
-
S
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
-
I
G
F
R
D
D
L
E
T
I
S
G
I
L
N
E
K
N
S
K
--
S
----
A
----
D
-------
N
--
I
-
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
----
D
----
K
--
N
EPEA
H
E
R
I
D
Q
---
S
V
-
V
-
I
-
S
-
E
-
K
F
A
N
----
S
----
I
F
A
A
V
E
-
H
-
I
K
K
Q
I
K
E
R
D
SN
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
----
N
---
E
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
K
D
E
-
L
P
F
V
R
E
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
48.46
31%
51
- C1 -
-
3I5X
2
MS116_YEAST
A:
[79-459]
-------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
S
--
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
-------------------
I
-
N
T
KFD
S
Q
------------------
Y
---
M
----
V
--------
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
G
L
------
K
-
K
----
Y
A
C
V
-
S
L
V
G
G
T
-
D
F
R
A
A
M
N
K
M
N
K
L
R
P
-
N
-
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
K
--
Y
-
S
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
-
I
G
F
R
D
D
L
E
T
I
S
G
I
L
N
E
K
N
S
K
--
S
----
A
----
D
-------
N
--
I
-
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
----
D
----
K
--
N
EPEA
H
E
R
I
D
Q
---
S
V
-
V
-
I
-
S
-
E
-
K
F
A
N
----
S
----
I
F
A
A
V
E
-
H
-
I
K
K
Q
I
K
E
R
D
SN
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
----
N
---
E
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
K
D
E
-
L
P
F
V
R
E
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
48.41
31%
50
- C1 -
-
4TZ6
2
MS116_YEAST
A:
[26-406]
-------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
PI
L
S
S
--
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
-------------------
I
-
N
T
KFD
S
Q
------------------
Y
---
M
----
V
--------
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
G
L
------
K
-
K
----
Y
A
C
V
-
S
L
V
G
G
T
-
D
F
R
A
A
M
N
K
M
N
K
L
R
P
-
N
-
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
K
--
Y
-
S
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
-
I
G
F
R
D
D
L
E
T
I
S
G
I
L
N
E
K
N
S
K
--
S
----
A
----
D
-------
N
--
I
-
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
----
D
----
K
--
N
EPEA
H
E
R
I
D
Q
---
S
V
-
V
-
I
-
S
-
E
-
K
F
A
N
----
S
----
I
F
A
A
V
E
-
H
-
I
K
K
Q
I
K
E
R
D
SN
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
----
N
---
E
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
K
D
E
-
L
P
F
V
R
E
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
48.13
31%
52
- C1 -
-
4TYW
2
MS116_YEAST
A:
[27-407]
-------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
PI
L
S
S
--
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
-------------------
I
-
N
T
KFD
S
Q
------------------
Y
---
M
----
V
--------
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
G
L
------
K
-
K
----
Y
A
C
V
-
S
L
V
G
G
T
-
D
F
R
A
A
M
N
K
M
N
K
L
R
P
-
N
-
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
K
--
Y
-
S
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
-
I
G
F
R
D
D
L
E
T
I
S
G
I
L
N
E
K
N
S
K
--
S
----
A
----
D
-------
N
--
I
-
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
----
D
----
K
--
N
EPEA
H
E
R
I
D
Q
---
S
V
-
V
-
I
-
S
-
E
-
K
F
A
N
----
S
----
I
F
A
A
V
E
-
H
-
I
K
K
Q
I
K
E
R
D
SN
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
----
N
---
E
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
K
D
E
-
L
P
F
V
R
E
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
47.98
46%
-30
- C1 -
-
2GXS
2
?
B:
[1-205]
M
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
--
L
A
L
--
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
-------------------
A
-
P
----
S
Q
------------------
E
RGR
K
----
P
--------
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
-----
T
A
V
--------
A
-
P
----
H
L
K
V
V
A
V
Y
G
G
T
-
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
-
D
-
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
Q
--
G
-
V
L
D
L
-
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
-
M
G
F
E
E
E
V
E
A
L
L
-------
S
A
--
T
----
P
----
P
-------
S
--
R
-
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
47.74
31%
55
- C1 -
-
3I5Y
2
MS116_YEAST
A:
[79-459]
-------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
S
--
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
-------------------
I
-
N
T
KFD
S
Q
------------------
Y
---
M
----
V
--------
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
G
L
------
K
-
K
----
Y
A
C
V
-
S
L
V
G
G
T
-
D
F
R
A
A
M
N
K
M
N
K
L
R
P
-
N
-
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
K
--
Y
-
S
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
-
I
G
F
R
D
D
L
E
T
I
S
G
I
L
N
E
K
N
S
K
--
S
----
A
----
D
-------
N
--
I
-
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
----
D
----
K
--
N
EPEA
H
E
R
I
D
Q
---
S
V
-
V
-
I
-
S
-
E
-
K
F
A
N
----
S
----
I
F
A
A
V
E
-
H
-
I
K
K
Q
I
K
E
R
D
SN
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
----
N
---
E
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
K
D
E
-
L
P
F
V
R
E
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
47.36
37%
-20
- C1 -
-
4PX9
1
DDX3X_HUMAN
C:
[67-290]
--
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
--
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
YSDGPGEALRAMKENGRYG
R
-
R
----
K
Q
------------------
Y
---
P
----
I
---------
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
-----
R
K
F
S
Y
------
R
-
S
----
R
V
R
P
C
V
V
Y
G
G
A
-
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
-
H
-
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
R
--
G
-
K
I
G
L
-
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
-
M
G
F
E
P
Q
I
R
R
I
V
-------
E
Q
DT
M
----
P
----
P
-------
K
GV
R
-
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
--
E
Y
I
F
L
A
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
47.24
31%
52
- C1 -
-
4TYY
2
MS116_YEAST
A:
[26-406]
-------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
PI
L
S
S
--
E
--
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
-------------------
I
-
N
T
KFD
S
Q
------------------
Y
---
M
----
V
--------
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
G
L
------
K
-
K
----
Y
A
C
V
-
S
L
V
G
G
T
-
D
F
R
A
A
M
N
K
M
N
K
L
R
P
-
N
-
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
K
--
Y
-
S
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
-
I
G
F
R
D
D
L
E
T
I
S
G
I
L
N
E
K
N
S
K
--
S
----
A
----
D
-------
N
--
I
-
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
----
D
----
K
--
N
EPEA
H
E
R
I
D
Q
---
S
V
-
V
-
I
-
S
-
E
-
K
F
A
N
----
S
----
I
F
A
A
V
E
-
H
-
I
K
K
Q
I
K
E
R
DSN
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
----
N
---
E
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
K
D
E
-
L
P
F
V
R
E
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
46.88
37%
-20
- C1 -
-
4PX9
1
DDX3X_HUMAN
A:
[67-290]
--
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
--
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
GPGEALRAMKENGRYG
R
-
R
----
K
Q
------------------
Y
---
P
----
I
---------
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
-----
R
K
F
S
Y
------
R
-
S
----
R
V
R
P
C
V
V
Y
G
G
A
-
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
-
H
-
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
R
--
G
-
K
I
G
L
-
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
-
M
G
F
E
P
Q
I
R
R
I
V
-------
E
Q
DT
M
----
P
----
P
-------
K
GV
R
-
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
--
E
Y
I
F
L
A
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
46.76
37%
-19
- C1 -
-
4PX9
1
DDX3X_HUMAN
B:
[67-290]
--
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
--
I
I
K
--
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
GPGEALRAMKENGRYG
R
-
R
----
K
Q
------------------
Y
---
P
----
I
---------
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
-----
R
K
F
S
Y
------
R
-
S
----
R
V
R
P
C
V
V
Y
G
G
A
-
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
-
H
-
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
R
--
G
-
K
I
G
L
-
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
-
M
G
F
E
P
Q
I
R
R
I
V
-------
E
Q
DT
M
----
P
----
P
-------
K
GV
R
-
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
--
E
Y
I
F
L
A
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
45.21
37%
-36
- C1 -
-
5GVR
1
DDX41_HUMAN
A:
[15-231]
--
F
K
E
M
K
F
P
A
A
I
L
R
G
L
K
K
K
G
I
H
H
P
T
P
I
Q
I
Q
G
I
P
--
T
I
L
--
S
--
G
--
R
D
M
I
G
I
A
F
T
G
S
G
K
T
L
V
F
T
L
P
V
I
M
F
C
-------------------
L
-
E
----
Q
E
------------------
K
---
R
----
L
PFSKREGP
Y
G
L
I
I
C
P
S
R
E
L
A
R
Q
T
H
G
I
L
-----
E
Y
Y
C
R
L
L
Q
E
D
S
S
-
P
----
L
L
R
C
A
L
C
I
G
G
M
-
S
V
K
E
Q
M
E
T
I
-
R
H
G
V
-
H
-
M
M
V
A
T
P
G
R
L
M
D
L
L
-
Q
K
--
K
-
M
V
S
L
-
D
I
C
R
Y
L
A
L
D
E
A
D
R
M
I
---
D
-
M
G
F
E
G
D
I
R
T
I
F
-------
S
Y
--
F
----
K
----
G
-------
Q
--
R
-
Q
T
L
L
F
S
A
T
M
P
K
K
I
Q
N
F
A
K
S
A
L
V
K
P
V
T
I
N
V
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
41.87
38%
-6
- C1 -
-
2PL3
5
DDX10_HUMAN
A:
[26-234]
-
R
F
S
D
F
P
L
S
K
K
T
L
K
G
L
Q
E
A
Q
Y
R
L
V
T
E
I
Q
K
Q
T
I
G
--
L
A
L
--
Q
--
G
--
K
D
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
V
L
E
A
L
-------------------
Y
-
R
----
L
Q
------------------
W
---
T
STDG
L
--------
G
V
L
I
I
S
P
T
R
E
L
A
Y
Q
T
F
E
V
L
-----
R
K
V
G
K
------
N
-
H
----
D
F
S
A
G
L
I
I
G
G
---
L
K
H
E
A
E
R
I
--
N
N
I
-
N
-
I
L
V
C
T
P
G
R
L
L
Q
H
M
-
D
E
--
T
V
S
F
H
A
-
T
D
L
Q
M
L
V
L
D
E
A
D
R
I
L
---
D
-
M
G
F
A
D
T
M
N
A
V
I
-------
E
N
--
L
----
P
----
K
-------
K
--
R
-
Q
T
L
L
F
S
A
T
Q
T
K
S
V
K
D
L
A
R
L
S
L
K
N
P
E
Y
V
W
V
H
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
PsiBlast_CBE
36.08
35%
9
- C1 -
-
3FMO
1
DD19B_HUMAN
B:
[94-297]
--
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
--
L
M
L
AE
P
--
P
--
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
-------------------
E
-
P
----
A
N
------------------
K
---
Y
----
P
--------
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
-----
E
Q
M
G
K
F-----
Y
-
P
----
E
L
K
L
A
Y
A
V
R
G
N
-
K
L
E
---
R
G
Q
-
K
I
S
E
-
Q
-
I
V
I
G
T
P
G
T
V
L
D
W
C
S
K
L
--
K
-
F
I
D
P
-
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
---
A
-
T
Q
G
H
Q
D
Q
S
I
R
I
-------
Q
R
M
-
L
----
P
----
R
-------
N
--
C
-
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
PsiBlast_CBE
34.54
32%
-20
- C1 -
-
3DKP
3
DDX52_HUMAN
A:
[33-220]
----
E
Y
K
I
N
S
R
L
L
Q
N
I
L
D
A
G
F
Q
M
P
T
P
I
Q
M
Q
A
I
P
--
V
M
L
--
H
--
G
--
R
E
L
L
A
S
A
P
T
G
S
G
K
T
L
A
F
S
I
P
I
L
M
Q
L
-------------------
K
Q
P
----
A
N
------------------
K
---
G
----
F
--------
R
A
L
I
I
S
P
T
R
E
L
A
S
Q
I
H
R
E
L
-----
I
K
I
S
E
------
G
-
T
----
G
F
R
I
H
M
I
H
K
A
A
-
V
A
A
K
K
F
G
P
K
-
S
S
K
K
-
F
D
I
L
V
T
T
P
N
R
L
I
Y
L
L
-
K
Q
DP
P
-
G
I
D
L
-
A
S
V
E
W
L
V
V
D
E
S
D
K
L
F
E
D
G---
G
F
R
D
Q
L
A
S
I
F
-------
L
A
--
C
----
T
----
S
-------
H
--
K
V
R
R
A
M
F
S
A
T
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------