@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1736: (2018-01-18 )
MILLAILFTCFSVYLELEVPTYISKITDLLGSQGTNLDELWQPASMMMGMPFLAFLSVVAVGFFASRVAASYTSRLRSDIFNRVLDYSQTEIKKFSIPSLLMRTTNDITQVQMLITMDLQVVTCGPIMAIWAIGKILGHSEYWLWAVLVAVIVNVLMTTVLMTLAFPKQSLIQGLTDKLNSITRESLTGIRVVRAYNAEDYQNEKFAAVNDELTR
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30.....------.-..40..---......50--........60......--------..70-...---.....80....--....90.....----...100.......110.......120.......130.......140.....-.--.--150.......---160.....---------.--.170---.........180---....---.....190.......200.......210...--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
L
L
A
I
L
F
T
C
F
S
V
Y
L
ELEV
P
T
Y
I
S
K
I
T
D
L
LGSQGT
N
------
L
-
D
E
L
W
Q
P
---
A
S
M
MMG
M
P
--
F
L
A
F
L
S
V
V
A
V
G
F
F
A
S
R
--------
V
A
A
S
-
Y
T
S
---
R
L
R
S
D
I
F
N
R
V
L--DY
S
Q
T
E
I
K
KFS----I
P
S
L
L
M
R
TTN
D
I
T
Q
V
Q
M
L
I
T
M
D
L
Q
V
V
TCG
P
I
M
A
I
W
A
I
G
K
I
LGHS
E
Y
W
L
W
A
V
-
L
--
V
--
A
V
I
V
N
V
L
M
T
T
---
V
L
M
T
LAF
P
---------
K
--
Q
S
-----
L
I
Q
G
L
T
D
K
L
N
-----
S
I
T
R
---
E
SLT
G
I
R
V
V
R
A
YNAEDYQNEKFAAVNDELTR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
88.57
29%
-175
- C6 -
-
3QF4
1
?
A:
[26-237]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
-
D
------
F
-
S
L
V
L
K
T
---
G
I
L
M
L
I
V
A
--
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
Y
--------
A
S
Q
N
-
F
G
A
---
D
L
R
R
D
L
F
R
K
V
L
--
S
F
S
I
S
N
V
N
R
F
H
----
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
--------------
F
V
G
G
I
-
V
--
M
--
A
V
S
I
N
V
K
L
S
S
---
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
--
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
-----
R
V
V
R
---
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
87.11
29%
-171
- C6 -
-
4Q4A
1
?
A:
[26-237]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
-
D
------
F
-
S
L
V
L
K
T
---
G
I
L
M
L
I
V
A
--
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
Y
--------
A
S
Q
N
-
F
G
A
---
D
L
R
R
D
L
F
R
K
V
L
--
S
F
S
I
S
N
V
N
R
F
H
----
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
--------------
F
V
G
G
I
-
V
--
M
--
A
V
S
I
N
V
K
L
S
S
---
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
--
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
-----
R
V
V
R
---
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
85.43
30%
-
- C6 -
-
4Q4H
-
?
A:
[18-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
-
D
------
F
-
S
L
V
L
K
T
---
G
I
L
M
L
I
V
A
--
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
Y
--------
A
S
Q
N
-
F
G
A
---
D
L
R
R
D
L
F
R
K
V
L
--
S
F
S
I
S
N
V
N
R
F
H
----
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
--
V
K
L
S
S
-
V
L
I
F
--
L
I
P
P
I
V
L
L
F
V
---
W
L
T
K
K
G
N
P
---------
L
--
F
R
-----
K
I
Q
E
S
T
D
E
V
N
-----
R
V
V
R
---
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.00
29%
-
- C6 -
-
4Q4H
-
?
A:
[16-227]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
-
D
------
F
-
S
L
V
L
K
T
---
G
I
L
M
L
I
V
A
--
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
Y
--------
A
S
Q
N
-
F
G
A
---
D
L
R
R
D
L
F
R
K
V
L
--
S
F
S
I
S
N
V
N
R
F
H
----
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
--------------
F
V
G
G
I
-
V
--
M
--
A
V
S
I
N
V
K
L
S
S
---
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
--
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
-----
R
V
V
R
---
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.83
29%
-156
- C6 -
-
4Q4J
-
?
A:
[16-227]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
P
L
F
M
V
V
E
V
I
S
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
-
D
------
F
-
S
L
V
L
K
T
---
G
I
L
M
L
I
V
A
--
L
I
G
A
V
G
G
I
G
S
T
V
F
A
S
Y
--------
A
S
Q
N
-
F
G
A
---
D
L
R
R
D
L
F
R
K
V
L
--
S
F
S
I
S
N
V
N
R
F
H
----
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
--------------
F
V
G
G
I
-
V
--
M
--
A
V
S
I
N
V
K
L
S
S
---
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
--
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
-----
R
V
V
R
---
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
71.83
19%
-
- C6 -
-
4Q4H
-
Y288_THEMA
B:
[42-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
-
R
------
F
-
D
L
L
P
R
Y
---
M
L
I
L
G
T
I
Y
--
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
--------
L
S
Q
D
-
V
V
F
---
R
L
R
K
E
L
F
E
K
L
Q
--
R
V
P
V
G
F
F
D
R
T
P
----
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
--
V
I
L
S
L
-
V
T
L
S
--
I
V
P
L
T
V
L
I
T
Q
---
I
V
S
S
Q
T
R
K
---------
Y
--
F
Y
-----
E
N
Q
R
V
L
G
Q
L
N
-----
G
I
I
E
---
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
70.24
19%
-158
- C6 -
-
3QF4
-
Y288_THEMA
B:
[42-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
-
R
------
F
-
D
L
L
P
R
Y
---
M
L
I
L
G
T
I
Y
--
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
--------
L
S
Q
D
-
V
V
F
---
R
L
R
K
E
L
F
E
K
L
Q
--
R
V
P
V
G
F
F
D
R
T
P
----
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
--
V
I
L
S
L
-
V
T
L
S
--
I
V
P
L
T
V
L
I
T
Q
---
I
V
S
S
Q
T
R
K
---------
Y
--
F
Y
-----
E
N
Q
R
V
L
G
Q
L
N
-----
G
I
I
E
---
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
69.72
19%
-125
- C6 -
-
5MKK
-
?
A:
[30-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
L
F
L
L
V
V
T
L
A
A
A
A
T
P
L
F
F
K
W
A
I
D
L
A
L
V
P
T
E
P
R
P
L
A
E
R
F
-
H
L
L
L
W
I
---
S
L
G
F
L
A
V
R
--
A
V
H
F
A
A
T
Y
G
E
T
Y
L
I
Q
W
--------
V
G
Q
R
-
V
L
F
---
D
L
R
S
D
L
F
A
K
L
M
--
R
L
H
P
G
F
Y
D
R
N
P
----
V
G
R
L
M
T
R
V
T
S
D
V
D
A
I
N
Q
F
I
T
G
G
L
V
G
V
I
A
D
L
F
T
L
V
G
L
L
G
F
M
L
F
L
S
--
P
K
L
T
L
-
V
V
L
L
--
V
A
P
V
L
L
A
V
T
T
---
W
V
R
L
G
M
R
S
---------
A
--
Y
R
-----
E
M
R
L
R
L
A
R
V
N
-----
A
A
L
Q
---
E
N
L
S
G
V
E
T
I
Q
L
F
V
K
E
R
E
R
E
E
K
F
D
R
L
N
R
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
67.92
18%
-157
* C6 *
-
5MKK
-
?
B:
[26-230]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
A
G
L
V
S
I
F
F
F
V
L
T
P
Y
F
L
R
L
A
V
D
A
V
Q
A
G
R
-----------
G
F
G
V
Y
---
A
L
A
I
V
A
S
A
--
A
L
S
G
L
L
S
Y
A
M
R
R
L
A
V
V
--------
A
S
R
Q
-
V
E
Y
---
D
L
R
R
D
L
L
H
H
L
L
--
T
L
D
R
D
F
Y
H
K
H
R
----
V
G
D
L
M
N
R
L
N
T
D
L
S
A
V
R
E
M
V
G
P
G
I
L
M
G
S
R
L
S
F
L
V
L
L
A
F
L
S
M
Y
A
V
N
--
A
R
L
A
F
-
Y
L
T
L
--
I
L
P
G
I
F
L
A
M
R
---
F
L
L
R
L
I
D
R
---------
R
--
Y
R
-----
E
A
Q
E
V
F
D
R
I
S
-----
T
L
A
Q
---
E
A
F
S
G
I
R
V
V
K
G
Y
A
L
E
R
R
M
V
A
W
F
Q
D
L
N
R
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
66.51
19%
-132
- C6 -
-
5U1D
-
TAP2_HUMAN
B:
[155-361]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
F
F
L
V
L
A
V
L
G
E
T
L
I
P
H
Y
S
G
R
V
I
D
I
L
G
G
D
F
-
D
------
P
-
H
A
F
A
S
A
---
I
F
F
M
C
L
F
S
--
F
G
S
S
L
S
A
G
C
R
G
G
C
F
T
Y
--------
T
M
S
R
-
I
N
L
---
R
I
R
E
Q
L
F
S
S
L
L
--
R
Q
D
L
G
F
F
Q
E
T
K
----
T
G
E
L
N
S
R
L
S
S
D
T
T
L
M
S
N
W
L
P
L
N
A
N
V
L
L
R
S
L
V
K
V
V
G
L
Y
G
F
M
L
S
I
S
--
P
R
L
T
L
-
L
--
S
L
L
H
M
P
F
T
I
A
A
E
K
---
V
Y
N
T
R
H
Q
E
---------
V
--
L
R
-----
E
I
Q
D
A
V
A
R
A
G
-----
Q
V
V
R
---
E
A
V
G
G
L
Q
T
V
R
S
F
G
A
E
E
H
E
V
C
R
Y
K
E
A
L
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
60.28
19%
-125
- C6 -
-
4AYW
2
ABCBA_HUMAN
A:
[55-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
-------
V
-
D
Y
S
D
N
L
---
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
--------
T
S
G
Q
R
I
V
N
---
R
L
R
T
S
L
F
S
S
I
L
--
R
Q
E
V
A
F
F
D
K
T
R
----
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
-----
F
F
V
S
P
N
-
L
--
A
--
T
F
V
L
S
V
V
P
P
V
---
S
I
I
A
V
I
Y
G
---------
R
Y
L
R
K
-----
L
T
K
V
T
Q
D
S
L
A
-----
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
59.70
19%
-110
- C6 -
-
5U1D
-
TAP2_HUMAN
B:
[151-351]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
V
A
A
F
F
F
L
V
L
A
V
L
G
E
T
L
I
P
H
Y
S
G
R
V
I
D
I
L
G
G
D
--------------
F
D
P
H
A
F
A
S
A
I
F
F
M
C
--
L
F
S
F
G
S
S
L
S
A
G
C
R
G
G
C
--------
F
T
Y
T
-
M
S
R
I
N
L
R
I
R
E
Q
L
F
S
S
L
L
--
R
Q
D
L
G
F
F
Q
E
T
K
----
T
G
E
L
N
S
R
L
S
S
D
T
T
L
M
S
N
W
L
P
L
N
A
N
V
L
L
R
S
L
V
K
V
V
G
L
Y
G
F
M
L
S
I
S
P
R
L
T
L
L
S
-
L
--
L
--
H
M
P
F
T
I
A
A
E
K
---
V
Y
N
T
R
H
Q
E
---------
V
--
L
R
-----
E
I
Q
D
A
V
A
R
A
G
-----
Q
V
V
R
---
E
A
V
G
G
L
Q
T
V
R
S
F
G
A
E
E
H
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
57.49
25%
-111
- C6 -
-
5MKK
-
?
A:
[77-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
F
L
A
V
R
A
V
H
F
A
A
T
Y
G
E
T
Y
L
I
Q
W
V
G
Q
R
-
V
L
F
---
D
L
R
S
D
L
F
A
K
L
M
--
R
L
H
P
G
F
Y
D
R
N
P
----
V
G
R
L
M
T
R
V
T
S
D
V
D
A
I
N
Q
F
I
T
G
G
L
V
G
V
I
A
D
L
F
T
L
V
G
L
L
G
F
M
L
F
L
S
P
K
L
T
L
V
V
-
L
--
L
--
V
A
P
V
L
L
A
V
T
T
W
V
R
L
G
M
R
S
A
Y
R
---------
E
--
M
R
-----
L
---
R
L
A
R
V
N
-----
A
A
L
Q
---
E
N
L
S
G
V
E
T
I
Q
L
F
V
K
E
R
E
R
E
E
K
F
D
R
L
N
R
D
L
F
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
57.01
19%
-117
- C6 -
-
4AYX
6
ABCBA_HUMAN
A:
[24-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
-------
V
-
D
Y
S
D
N
L
---
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
--------
T
S
G
Q
R
I
V
N
---
R
L
R
T
S
L
F
S
S
I
L
--
R
Q
E
V
A
F
F
D
K
T
R
----
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
-----
F
F
V
S
P
N
-
L
--
A
--
T
F
V
L
S
V
V
P
P
V
---
S
I
I
A
V
I
Y
G
---------
R
Y
L
R
K
-----
L
T
K
V
T
Q
D
S
L
A
-----
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
56.92
19%
-120
- C6 -
-
3ZDQ
6
ABCBA_HUMAN
A:
[24-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
-------
V
-
D
Y
S
D
N
L
---
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
--------
T
S
G
Q
R
I
V
N
---
R
L
R
T
S
L
F
S
S
I
L
--
R
Q
E
V
A
F
F
D
K
T
R
----
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
-----
F
F
V
S
P
N
-
L
--
A
--
T
F
V
L
S
V
V
P
P
V
---
S
I
I
A
V
I
Y
G
---------
R
Y
L
R
K
-----
L
T
K
V
T
Q
D
S
L
A
-----
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
56.71
19%
-120
- C6 -
-
4AYT
6
ABCBA_HUMAN
A:
[24-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
-------
V
-
D
Y
S
D
N
L
---
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
--------
T
S
G
Q
R
I
V
N
---
R
L
R
T
S
L
F
S
S
I
L
--
R
Q
E
V
A
F
F
D
K
T
R
----
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
-----
F
F
V
S
P
N
-
L
--
A
--
T
F
V
L
S
V
V
P
P
V
---
S
I
I
A
V
I
Y
G
---------
R
Y
L
R
K
-----
L
T
K
V
T
Q
D
S
L
A
-----
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
55.54
16%
-114
- C6 -
-
5UAR
-
CFTR_DANRE
A:
[84-545]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
G
F
L
L
Y
I
G
E
A
T
K
T
V
Q
P
Q
L
L
G
R
I
I
A
S
F
D
P
A
H
E
P
------
E
R
A
N
G
Y
F
L
---
A
F
G
L
G
L
L
F
--
T
A
R
F
L
L
L
Q
P
A
M
F
G
L
H
H
--------
L
G
M
Q
-
I
R
I
---
A
L
F
S
I
I
Y
K
K
T
L
--
K
L
S
S
R
V
L
D
K
I
S
----
T
G
Q
L
V
S
L
M
S
A
N
L
G
K
F
D
Q
S
L
G
M
A
H
F
I
W
I
-
S
P
L
Q
C
I
L
C
T
G
L
I
W
E
L
I
-
D
V
N
S
F
C
A
L
--
A
--
A
I
S
L
L
G
V
L
Q
A
---
F
L
S
H
K
M
G
P
---------
Y
--
K
A
-----
Q
K
V
L
L
T
N
K
R
L
-----
A
L
T
S
---
E
I
M
E
N
L
H
S
V
K
A
Y
G
W
E
E
I
M
E
T
L
I
K
N
I
R
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
55.16
17%
-
- C6 -
-
3B5X
-
MSBA_VIBCH
A:
[29-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
T
I
A
L
V
I
N
A
A
A
D
T
Y
M
I
S
L
L
K
P
L
L
D
E
G
F
G
N
A
-
E
------
S
-
N
F
L
R
I
L
---
P
F
M
I
L
G
L
M
--
F
V
R
G
L
S
G
F
A
S
S
Y
C
L
S
W
--------
V
S
G
N
-
V
V
M
---
Q
M
R
R
R
L
F
N
H
F
M
--
H
M
P
V
R
F
F
D
Q
E
S
----
T
G
G
L
L
S
R
I
T
Y
D
S
E
Q
V
A
G
A
T
S
R
A
L
V
S
I
V
R
E
G
A
S
I
I
G
L
L
T
L
M
F
W
N
S
--
W
Q
L
S
L
-
V
--
L
IV
V
A
P
V
V
A
F
A
I
S
---
F
V
S
K
R
F
R
K
---------
I
--
S
R
-----
N
M
Q
T
A
M
G
H
V
T
-----
S
S
A
E
---
Q
M
L
K
G
H
K
V
V
L
S
Y
G
G
Q
E
V
E
R
K
R
F
D
K
V
S
N
S
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
55.14
15%
-113
- C5 -
-
3W3W
-
IMB3_YEAST
A:
[3-1077]
ALP
E
E
V
N
R
T
L
L
Q
I
V
Q
A
FASD
N
Q
I
R
S
V
A
E
K
A
L
S
EEWITENN
I
E
Y
L
L
T
F
L
A
E
Q
A
A
FSQD
T
T
V
A
A
L
S
A
V
L
F
R
K
L
A
L
K
A
PITHIR
K
E
V
L
A
Q
I
R
S
S
L
L
K
G
F
L
SERA
D
S
I
R
H
K
L
S
D
A
I
A
E
C
VQDDLPAW
P
E
L
L
Q
A
L
I
E
S
L
K
SGN
P
N
F
R
E
S
S
F
R
I
L
T
T
V
P
Y
L
I
T
A
VD
I
N
S
I
L
P
I
F
Q
S
G
F
T
DAS
D
N
V
K
I
A
A
V
T
A
F
V
G
Y
F
K
Q
LPKSEWSKLGIL
L
P
S
L
L
N
S
L
P
R
F
L
D
D
GK
D
D
A
L
A
S
V
F
E
S
L
I
E
L
V
E
L
APKLFKDM
F
D
Q
I
I
Q
F
T
D
M
V
I
K
NKDLEP
P
A
R
T
T
A
L
E
L
L
T
V
F
S
E
N
A
P
Q
M
C
K
S
N
Q
N
Y
G
Q
T
L
V
M
V
T
L
I
M
M
T
EVSIDDDDA
A
E
W
I
E
SDDTDDEEE
V
T
Y
D
H
A
R
Q
A
L
D
R
V
A
L
K
LGGEYL
A
A
P
L
F
Q
Y
L
Q
Q
M
I
T
STE
W
R
E
R
F
A
A
M
M
A
L
S
S
A
A
E
G
C
A
D
V
L
I
G
E
I
P
K
I
L
D
M
V
I
P
L
I
N
D
P
H
-----------
P
R
V
Q
Y
---
G
C
C
N
V
L
G
Q
--
I
S
T
D
F
S
P
F
I
Q
R
T
A
H
D
R
--------
I
L
P
A
-
L
I
S
---
K
L
T
S
E
C
T
S
R
V
Q
--
T
H
A
A
A
A
L
V
N
F
S
E
FAS
K
D
I
L
E
P
Y
L
D
S
L
L
T
N
L
L
V
L
L
Q
S
N
K
L
Y
V
Q
E
Q
A
L
T
T
I
A
F
I
A
E
A
A
K
N
K
F
I
K
Y
Y
D
T
-
L
--
M
--
P
L
L
L
N
V
L
K
V
N
---
S
V
L
K
G
K
C
M
---------
E
--
C
A
-----
T
L
I
G
F
A
V
G
K
E
-----
K
F
H
E
---
H
S
Q
E
L
I
S
I
L
V
A
L
Q
N
S
D
A
L
R
S
Y
L
E
Q
S
W
S
R
I
C
R
I
L
GDDFVPLLPIVI
P
P
L
L
I
T
A
K
ATQDVGLIEEEEAANFQQYPD
W
D
V
V
Q
V
QG
K
H
I
A
I
H
T
S
V
L
D
D
K
V
S
A
M
E
L
L
Q
S
Y
A
T
L
L
RGQFAVY
V
K
E
V
M
E
EI
A
L
P
S
L
D
FYLH
D
G
V
R
A
A
G
A
T
L
I
P
I
L
L
S
C
L
L
A
AE
E
L
V
L
L
W
H
K
A
S
S
K
L
I
G
G
L
M
S
EPM
P
E
I
T
Q
V
Y
H
N
S
L
V
N
G
I
K
V
M
GDNCLS
E
D
Q
L
A
A
F
T
K
G
V
S
A
N
L
T
D
T
Y
E
R
M
Q
DRDEYNED
F
T
D
E
D
L
L
D
E
I
N
K
S
I
A
A
V
L
K
T
T
N
GHY
L
K
N
L
E
N
I
W
P
M
I
N
T
F
L
LE
P
I
L
V
I
F
A
L
V
V
I
G
D
L
I
Q
YEQTASMKNAF
I
P
K
V
T
E
C
L
ISPD
A
R
I
R
Q
A
A
S
Y
I
I
G
V
C
A
Q
YAPSTYADVCIPT
L
D
T
L
V
Q
I
V
DGSKLEEN
R
S
S
T
E
N
A
S
A
A
I
A
K
I
L
Y
A
Y
NSNIPD
T
Y
T
A
N
W
F
K
T
LPTITD
K
E
A
A
S
F
N
Y
Q
F
L
S
QVCAQSN
I
S
A
V
V
D
S
V
I
Q
A
L
N
E
RSLT
V
I
S
S
V
K
K
L
L
G
F
L
P
S
S
D
A
M
A
I
F
N
RYP
A
D
I
M
E
K
V
H
K
W
F
20
PsiBlast_PDB
53.77
23%
-108
- C6 -
-
4M1M
-
MDR1A_MOUSE
A:
[746-909]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
S
N
------
L
-
F
S
L
--------
L
F
L
I
L
G
--
I
I
S
F
I
T
F
F
L
Q
G
F
T
F
G
K
--------
A
G
E
I
-
L
T
K
---
R
L
R
Y
M
V
F
K
S
M
L
R
Q
D
V
S
W
F
D
D
P
K
N
T
----
T
G
A
L
T
T
R
L
A
N
D
A
A
Q
V
K
G
A
T
G
S
R
L
A
V
I
F
Q
N
--
I
A
N
L
G
T
G
I
I
I
S
L
I
Y
G
W
Q
L
T
L
-
L
--
L
--
L
A
I
V
P
I
I
A
I
A
---
G
V
V
E
M
------------
K
--
M
L
-----
S
G
Q
A
L
K
D
K
K
E
L
E
G
S
G
K
I
A
T
---
E
A
I
E
N
F
R
T
V
V
S
L
T
R
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------