@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr2036: (2018-01-25 )
MKSFLKTYRTYFISLIIPVVIMSGVYLSQGIYWNSDNSPLLGDGFHQYVIFDVALRNILHGNSSLFYTFTSGLGLNFYALSSYYLGSFLAPLVYFFDLTNMPDAVYLTTLLKFGLIGLSTFFSLNKLFQSIPQTLKLALSTSYALMSFTVSQLEIKTWLDVFILIPLIITGLHLLITEKKLLLYFTSLSILFIQNYYFGYMTVLFLIFWYLCQISWDFKTRKSSVLDFIVISFLAGMASLIMTLPTLFDLQTHGEKLTEVTKFQTESSWYLDLFAKQFIGSFDTTKYGAIPMIFVGLFPFILTILFFTLKSIKFHVKLIYVIFFAFLIASFYIEALDLFWQGMHTPNMFLHRYAWIFSTLLIYTAAEVLKRLKELKVWNFLVSLFLVVAGFLATIYLKSHYSFLTDLNILLTLEFLVVYSLLLLAVIKKFISVNLFAILISLFILVEMSLNASSQMDGIAKEWGFASRSAYSRDILAMESFSTYIGNQFTRTEKLQTQTGNDSMKFNYNGISQFSSVRNRSSSSTLDKLGFKSSGTNLNLRYANNSILADSLFGIQYNISDSPIDKYGFKDIYQKDNLTLYENQYSLPIAVASQSVYNDVKFNEHTLDNQASFLNQLANVNFDYFSPIPYEKTEKIENTNDLISVTSSSNEDAAIQYQIEVPENSQVYLSFINLHFSNDKQKKVDILVNGEKKTFTTDNVFSFFNLGYTKEKKTFNINVSFPGNSQVSFESPTFYRLDTKTFTEAIQKIKEQPVTVSTSKNKVFATYDVQQDTSIFFTIPYDKGWSAYQDGKKIEIKQAQTGFMKVDIPKGKGTITLSFIPNGFITGAICSFTSLLLFGIYNHRRKSSKA
Atome Classification :
(20 SA)
.........10........20...--.....30........40........50....-------....60........70........80........90........100......-.110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210....----...220.......230.......240.......250.......260........270.......280.......290......----.300.......310.......320.......330.......340.......350...----....360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720........730.......740.......750......--.760.......770.......780.......790.......800.......810.......820.......830.......840.......850
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
S
F
L
K
T
Y
R
T
Y
F
I
S
L
I
I
P
V
V
I
MSG--
V
Y
LSQ
G
I
Y
WNSDNSPLLGDGF
H
Q
Y
V
I
F
D
V
A
L
-------
R
N
ILHGNS
S
L
F
Y
T
FTSGL
G
L
N
F
Y
A
L
S
S
Y
Y
L
G
S
F
L
A
P
L
V
Y
F
F
DLTNMP
D
A
V
Y
L
T
-
T
L
L
K
F
G
L
I
G
L
S
T
F
F
S
L
N
K
L
F
Q
S
I
P
Q
T
L
K
L
A
L
STS
Y
A
L
M
S
F
T
V
S
Q
L
E
I
K
T
W
L
D
V
F
I
L
I
P
L
I
I
T
G
L
H
L
L
I
TE
K
K
L
L
L
Y
F
TS
L
S
I
L
F
I
Q
N
Y
Y
F
G
Y
M
T
V
L
F
L
I
F
W
Y
L
C
Q
I
S
W
----DFKTR
K
S
S
V
L
D
F
I
V
I
S
F
L
A
G
M
A
S
L
I
M
T
L
P
T
L
FD
L
Q
TH
G
E
K
L
T
E
V
T-KFQTES
S
W
Y
L
D
L
F
A
K
Q
F
IGSFDTTKYGA
I
P
M
I
F
V
G
L
F
----
P
F
I
L
T
I
L
F
F
T
L
K
S
I
K
F
H
V
K
L
I
Y
V
I
F
F
A
F
L
I
A
S
F
Y
I
E
A
L
D
L
F
W
QGMHT
P
N
M
F
L
H
R
Y
A
W
----
I
F
S
T
L
L
I
Y
T
A
A
E
V
L
K
R
L
K
E
L
K
V
W
N
F
L
V
S
L
F
L
V
V
A
G
F
L
A
T
I
Y
L
K
S
H
Y
S
F
L
T
D
L
N
I
L
L
T
L
E
F
L
V
V
Y
S
L
L
L
L
A
V
I
K
K
F
I
S
V
N
L
F
A
I
L
I
S
L
F
I
L
V
EMSLNASS
Q
M
D
G
I
A
K
E
WGFASRSAYS
R
D
I
L
A
M
E
S
F
S
T
Y
IGNQFTR
T
E
K
L
QTQTGND
S
M
K
F
N
YN
G
I
S
Q
F
S
S
V
RNRSSSS
T
L
D
KLGFKSSG
T
N
L
N
L
R
YANNSI
L
A
D
S
L
F
G
I
Q
Y
NISDSP
I
D
KYG
F
K
D
I
YQKDN
L
T
L
Y
ENQYS
L
P
I
A
VASQSVYNDVKFNEHTL
D
N
Q
A
S
F
L
N
Q
L
ANVNFDYFSPIPY
E
K
T
EKIENTN
D
L
I
S
V
TSSSNE
D
A
A
I
Q
Y
Q
I
EVPEN
S
Q
V
Y
L
S
F
I
N
L
HFSNDK
Q
K
K
V
D
I
L
VNGEKKTFT
T
D
N
V
F
S
F
F
NLGY
T
K
E
K
K
T
F
N
I
N
V
SF-PGNSQVSFESP
T
F
Y
R
L
D
T
K
T
F
T
E
A
I
Q
K
I
KEQP
V
T
V
ST--SK
N
K
V
F
A
T
Y
DVQQD
T
S
I
F
F
T
I
PYDKGWSAYQDG
K
K
I
E
I
K
QAQTG
F
M
K
V
DIPKGK
G
T
I
T
L
S
FIPNGFI
T
G
A
I
C
S
F
T
S
L
L
L
F
G
I
Y
NHRRKSSKA
31
Fugue
69.55
17%
-109
- C3 -
-
5LNK
-
NU5M_SHEEP
L:
[1-599]
M
N
L
F
S
S
L
T
L
V
T
L
I
L
L
T
M
P
I
A
A
I
N
-------------
F
N
T
H
K
F
T
N
Y
P
L
Y
V
K
T
T
I
S
C
A
F
-------
I
T
S
M
I
P
T
M
M
F
I
H
T
G
Q
E
M
I
I
S
N
W
H
W
L
T
I
Q
T
L
K
L
S
L
S
F
K
M
D
F
F
S
M
M
F
V
P
V
A
L
F
V
T
W
S
I
M
E
F
S
M
W
Y
M
H
S
D
----------------------------------
P
N
I
N
Q
F
F
K
Y
L
L
L
F
L
I
T
M
L
I
L
V
T
-------
A
N
N
L
F
Q
L
F
I
G
W
E
G
V
G
I
M
S
F
L
L
I
G
W
W
Y
----------
G
R
T
D
A
N
T
A
A
L
Q
A
I
L
Y
N
R
I
G
D
I
G
F
I
L
A
M
A
W
F
L
I
N
L
N
T
W
D
--
L
Q
Q
I
F
-
M
L
N
P
N
D
S
----------------------------
N
L
----
P
L
M
G
L
I
L
A
A
T
G
K
S
A
Q
F
G
L
H
----------------
P
W
L
P
S
A
M
E
G
P
T
P
V
S
A
L
L
H
----------
S
S
T
M
V
V
A
G
I
F
L
L
I
R
F
Y
P
L
T
E
N
N
K
F
G
Q
S
I
M
L
C
L
G
A
M
T
T
L
F
T
A
M
C
A
L
T
Q
N
D
I
K
K
I
I
A
F
S
T
S
S
Q
L
G
L
M
M
V
T
I
G
I
N
Q
P
H
L
A
F
L
H
I
C
T
H
A
F
F
K
A
M
L
F
M
C
S
G
S
I
I
H
S
L
N
D
E
----------
Q
D
I
R
K
M
G
G
L
--
F
K
A
M
P
F
T
T
T
A
L
I
I
G
S
L
A
L
T
G
M
P
F
L
T
G
-------------------------------
F
Y
S
K
D
L
I
I
E
S
A
N
T
S
------------------
Y
T
N
A
W
A
L
L
M
T
L
V
A
T
S
F
T
A
I
Y
S
T
R
I
I
F
F
A
------
L
L
G
Q
P
R
F
P
T
---
L
I
N
I
N
E
N
N
P
F
L
I
N
S
I
K
R
L
L
I
G
S
L
F
A
G
F
I
I
S
N
N
I
P
P
M
T
I
P
Q
M
T
M
P
H
Y
L
--------------
K
M
T
A
L
T
V
T
I
L
G
F
I
L
A
L
E
I
S
N
T
T
H
Y
L
K
F
N
Y
P
S
N
T
F
K
F
S
N
L
L
G
Y
-
Y
P
T
I
M
H
R
L
T
P
Y
M
N
L
T
M
S
Q
K
S
A
S
S
L
L
D
L
I
W
L
E
T
I
L
P
K
T
-------------------------------------
I
S
L
A
Q
M
K
---
M
S
T
T
I
T
S
Q
K
G
L
I
K
L
Y
F
L
S
F
-
L
I
T
I
L
I
S
T
-------------------
16
PsiBlast_PDB
55.16
26%
-
- C4 -
-
4Q9K
-
MDR1A_MOUSE
A:
[381-556]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
K
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
------------------------------------------------------------------------------
15
PsiBlast_PDB
55.15
26%
-
- C4 -
-
4Q9J
-
MDR1A_MOUSE
A:
[381-556]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
K
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
------------------------------------------------------------------------------
30
Fugue
55.12
13%
-100
* C3 *
-
3RKO
4
?
B:
[1-612]
M
N
M
L
A
L
T
I
I
L
P
L
I
G
F
V
L
-
L
A
F
S
R
G
--
R
W
S
E
N
V
S
A
I
V
G
V
G
S
V
G
L
A
A
L
V
T
A
F
I
G
V
D
F
F
A
N
GE
Q
T
Y
S
Q
P
L
W
T
W
M
S
V
G
D
F
N
I
G
F
N
L
V
L
D
G
L
S
L
T
M
L
S
V
V
T
G
V
G
F
L
I
H
M
Y
A
S
W
Y
M
R
------------
G
E
E
G
Y
S
R
F
F
A
Y
T
N
L
F
--
I
A
S
M
V
V
L
V
L
A
D
N
---------------------------------------------
L
L
L
M
Y
L
G
W
E
G
V
G
L
C
S
Y
L
L
I
G
F
Y
Y
T
D
P
K
N
G
----
A
A
A
M
K
A
F
V
V
T
R
V
G
D
V
F
L
A
F
A
L
F
I
L
Y
N
E
L
G
T
L
----
N
F
R
E
M
V
E
L
A
P
-
A
H
F
A
D
G
N
N
M
L
M
W
A
T
L
M
L
L
G
G
A
-
V
G
K
S
A
Q
L
P
L
Q
----------------------------------------
T
W
L
A
D
A
M
A
----
G
P
T
P
V
S
A
L
I
H
A
A
T
M
----
V
T
A
G
V
Y
L
I
A
R
T
H
G
L
F
L
M
-
T
P
E
V
L
H
L
V
G
I
V
G
A
V
T
L
L
L
A
G
F
A
A
L
V
Q
-----
T
D
I
K
R
V
L
A
Y
S
T
M
S
Q
I
G
Y
M
F
L
A
L
G
V
Q
A
W
D
A
A
I
F
H
L
M
T
H
A
F
F
K
A
L
L
F
L
A
S
G
S
V
I
L
A
C
H
H
E
----------
Q
N
I
F
K
M
G
G
L
R
K
S
I
------------------------------------------------
P
L
V
Y
L
C
F
L
V
G
G
A
A
L
S
A
L
P
L
V
T
A
G
F
F
S
K
D
E
I
L
A
G
A
M
A
N
G
---------
H
I
N
L
M
V
A
G
L
V
G
A
F
M
T
S
L
Y
T
F
R
M
I
F
I
V
F
H
G
K
---------------
E
Q
I
H
A
H
A
V
K
G
V
T
H
S
L
P
L
I
V
L
L
I
L
S
T
F
V
G
A
L
I
V
P
P
L
Q
G
V
L
P
Q
T
T
--------
E
L
A
H
G
S
M
L
T
L
E
I
T
S
G
V
V
A
V
V
G
I
L
L
A
A
W
L
W
L
G
K
R
T
L
V
T
S
I
A
N
S
A
P
G
-
R
L
L
S
T
W
W
Y
N
A
W
G
F
D
W
L
Y
D
K
V
F
V
K
P
F
L
G
I
A
W
L
L
-----------------------------
K
R
D
P
L
N
S
M
M
N
I
P
A
V
L
S
R
F
A
G
K
G
L
L
L
S
E
------------------
N
G
Y
L
R
W
Y
V
A
S
M
S
I
G
A
V
V
V
L
A
L
L
M
V
L
13
PsiBlast_PDB
55.03
26%
-
- C4 -
-
4Q9H
-
MDR1A_MOUSE
A:
[381-556]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
K
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
------------------------------------------------------------------------------
14
PsiBlast_PDB
55.02
26%
-
- C4 -
-
4Q9I
-
MDR1A_MOUSE
A:
[381-559]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
K
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
------------------------------------------------------------------------------
17
PsiBlast_PDB
54.98
26%
-
- C4 -
-
4Q9L
-
MDR1A_MOUSE
A:
[381-556]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
K
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
------------------------------------------------------------------------------
39
Fugue
47.57
15%
-125
- C1 -
-
5DOQ
3
?
A:
[1-432]
----
M
N
G
Y
D
P
V
L
L
S
R
I
L
T
E
L
T
L
T
V
H
I
I
Y
A
T
I
G
V
G
V
P
L
M
I
A
I
A
Q
W
V
G
I
R
K
N
D
M
H
Y
I
L
L
-------
A
R
R
W
T
R
G
F
V
I
T
V
A
V
G
V
V
T
G
T
A
I
G
L
Q
L
S
L
L
W
P
N
F
M
Q
L
A
G
Q
V
I
S
L
P
L
F
M
E
T
F
A
F
F
-
F
E
A
I
F
L
G
I
Y
L
Y
T
W
D
R
F
E
N
Q
K
K
H
L
L
L
L
I
P
V
A
I
G
S
S
A
S
A
M
F
I
T
M
V
N
A
F
M
N
T
P
Q
G
------
F
E
L
K
N
G
E
L
V
N
I
D
P
I
V
A
M
F
N
P
A
M
P
T
K
V
A
H
V
L
A
T
S
Y
M
T
S
A
F
V
L
A
S
I
A
A
W
H
L
W
K
GNR
H
I
Y
H
R
K
A
L
H
L
T
M
K
T
A
F
I
F
S
V
A
S
A
L
V
G
D
L
S
G
K
F
L
A
E
Y
Q
P
E
K
L
A
A
A
E
W
H
F
E
T
S
S
H
A
P
L
I
L
F
G
T
L
E
E
D
N
-
E
V
K
Y
A
L
E
I
P
Y
A
L
S
I
L
A
HNHP
A
A
V
V
T
G
L
N
D
I
P
E
D
E
R
P
P
L
Y
I
H
Y
L
F
D
V
M
V
T
I
G
V
F
L
M
V
V
A
A
V
Y
W
L
G
S
------
I
F
R
W
K
W
TAKN
W
F
F
G
L
L
V
A
G
G
P
L
A
M
I
A
I
E
A
G
W
Y
L
A
E
V
G
R
Q
P
W
I
L
R
G
Y
M
K
T
A
E
G
A
T
T
S
A
H
V
D
T
M
L
V
L
F
C
L
L
Y
I
V
L
V
I
A
S
A
T
V
L
I
R
M
F
R
R
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
45.95
26%
-3
- C4 -
-
5KPI
-
MDR1A_MOUSE
A:
[381-554]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
K
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
------------------------------------------------------------------------------
9
PsiBlast_PDB
45.83
26%
-11
- C4 -
-
4M2T
-
MDR1A_MOUSE
A:
[381-548]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
K
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
------------------------------------------------------------------------------
8
PsiBlast_PDB
45.41
26%
-3
- C4 -
-
4M2S
-
MDR1A_MOUSE
A:
[381-548]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
K
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
------------------------------------------------------------------------------
4
PsiBlast_PDB
45.17
26%
-2
- C4 -
-
5KPJ
-
MDR1A_MOUSE
A:
[381-558]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
K
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
------------------------------------------------------------------------------
2
PsiBlast_PDB
45.11
26%
-9
- C4 -
-
5KPD
-
MDR1A_MOUSE
A:
[381-520]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
K
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
------------------------------------------------------------------------------
18
PsiBlast_PDB
45.04
26%
7
- C4 -
-
4XWK
-
MDR1A_MOUSE
A:
[381-556]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
K
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
------------------------------------------------------------------------------
5
PsiBlast_PDB
44.99
26%
-8
- C4 -
-
3G60
-
MDR1A_MOUSE
A:
[381-551]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
K
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
------------------------------------------------------------------------------
12
PsiBlast_PDB
44.66
26%
-9
- C4 -
-
4M1M
-
MDR1A_MOUSE
A:
[381-548]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
K
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
------------------------------------------------------------------------------
20
PsiBlast_PDB
44.10
26%
-11
- C4 -
-
4KSC
-
MDR1A_MOUSE
A:
[381-551]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
K
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
------------------------------------------------------------------------------
19
PsiBlast_PDB
43.97
26%
-15
* C4 *
-
4KSB
-
MDR1A_MOUSE
A:
[381-551]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
K
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
------------------------------------------------------------------------------
3
PsiBlast_PDB
43.94
26%
-1
- C4 -
-
5KOY
1
MDR1A_MOUSE
A:
[381-520]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
K
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
------------------------------------------------------------------------------
1
PsiBlast_PDB
43.78
26%
2
- C4 -
-
5KO2
-
MDR1A_MOUSE
A:
[381-520]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
K
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
------------------------------------------------------------------------------