@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKC7: (2017-10-26 )
MIVLGLETSCDETGLALYDSELGLRGQVLYSQIKLHAEYGGVVPELASRDHVRKLIPLMNQLLEQSGVKKQEIDAVAYTRGPGLMGALMTGALFGRTLAFSLNKPAIGVHHMEGHMLAPLLSSQPPEFPFVALLVSGGHTQLMVVHGIGQYELLGESIDDAAGEAFDKVAKMMNLPYPGGPNIAKLALSGDPLAFEFPRPMLHQGLDFSFSGLKTAVSVQLKKLNGENRDADIAASFQEAIVDTLVKKSVKALKQTGLKRLVIAGGVSANLRLREQLETSLARIKAQVYYAEPALCTDNGAMIAFAGYQRLKAGQHDGLAVTTTPRWPMTELTIPE
Atome Classification :
(20 SA)
.........10........20.....--...30.-...--...-.40........50........60........70........80........90........100.......110....-...120.--......130.......140.......150.......160.......170......-.180...---------....190.......200-..-.----....210.......220..-..-------...230.......240.......250...-----....260.......270.......280....-...290.......300.......310...-.---...320-.......330....-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
I
V
LGLETSCDET
G
L
A
L
Y
DSELGLR
G
--
Q
V
L
Y
S
Q
-
I
K
L
--
H
AE-YGGV
V
P
E
L
A
S
R
D
H
V
R
K
L
I
P
L
M
N
Q
L
L
E
QSGVKKQE
I
D
A
V
A
YTRGP
G
L
M
G
A
L
M
T
G
A
L
FG
R
T
L
A
F
SLNKPA
I
G
V
H
HMEG
H
M
-L
A
P
L
L
SS--QPPEF
P
F
V
A
L
L
VSGG
H
T
Q
L
M
V
V
HGIG
Q
Y
E
L
L
GESI
D
D
A
A
G
E
A
F
D
K
V
A
K
M
MNLPYP-GGP
N
I
A
K
---------
L
ALSGDP
L
A
FEFP
R
P
M
L
-HQ-G----LDFSFSGLK
T
A
V
S
V
Q
L
K
KL-NG-------ENR
D
A
D
I
A
A
S
F
Q
E
A
I
V
D
T
L
V
K
K
S
V
K
A
L
K
Q
-----TGL
K
R
L
V
I
AGGVSA
N
L
R
L
R
E
Q
L
E
T
S
L
A
R
I
K
A
-
Q
V
Y
YAEPALCTDNG
A
M
I
A
FAG
Y
Q
R
LKAGQ-H---D
G
L
A
V
T-TTPRWPMTELTIPE-
3
PsiBlast_PDB
86.86
62%
-60
- C2 -
-
3ZEU
1
TSAD_SALTY
B:
[1-334]
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
K
K
G
L
L
A
--
N
Q
L
Y
S
Q
-
V
K
L
--
H
A
D
-
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
E
D
--
N
P
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
-
G
G
P
M
L
S
K
---------
M
A
S
Q
G
T
A
G
R
F
V
F
P
R
P
M
T
-
D
R
P
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
S
N
-
G
G
D------
E
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
E
S
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
R
R
G
-
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
V
-
T
---
A
D
L
G
V
T
-
V
R
P
R
W
P
L
A
E
L
-----
22
PsiBlast_CBE
86.58
62%
-58
- C2 -
-
3ZEU
1
TSAD_SALTY
E:
[1-334]
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
K
K
G
L
L
A
--
N
Q
L
Y
S
Q
-
V
K
L
--
H
A
D
-
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
E
D
--
N
P
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
-
G
G
P
M
L
S
K
---------
M
A
S
Q
G
T
A
G
R
F
V
F
P
R
P
M
T
-
D
R
P
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
S
N
-
G
G
D------
E
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
E
S
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
R
R
G
-
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
V
-
T
---
A
D
L
G
V
T
-
V
R
P
R
W
P
L
A
E
L
-----
2
PsiBlast_PDB
86.12
62%
-61
- C2 -
-
3ZET
1
?
B:
[1-334]
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
K
K
G
L
L
A
--
N
Q
L
Y
S
Q
-
V
K
L
--
H
A
D
-
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
E
D
--
N
P
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
-
G
G
P
M
L
S
K
---------
M
A
S
Q
G
T
A
G
R
F
V
F
P
R
P
M
T
-
D
R
P
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
S
N
-
G
G
D------
E
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
E
S
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
R
R
G
-
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
V
-
T
---
A
D
L
G
V
T
-
V
R
P
R
W
P
L
A
E
L
-----
5
PsiBlast_PDB
85.94
62%
-58
- C2 -
-
4WQ4
1
TSAD_ECOLI
A:
[1-334]
M
R
V
L
G
I
E
T
S
C
D
A
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
--
N
Q
L
Y
S
Q
-
V
K
L
--
H
A
D
-
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
E
D
--
N
P
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
-
G
G
P
L
L
S
K
---------
M
A
A
Q
G
T
A
G
R
F
V
F
P
R
P
M
T
-
D
R
P
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
D
--
N
G
TD-----
D
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
Q
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
-
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
A
-
T
---
A
D
L
G
V
S
-
V
R
P
R
W
P
L
A
E
L
-----
21
PsiBlast_CBE
85.85
62%
-58
- C2 -
-
4YDU
2
TSAD_ECOLI
B:
[1-334]
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
--
N
Q
L
Y
S
Q
-
V
K
L
--
H
A
D
-
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
E
D
--
N
P
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
-
G
G
P
L
L
S
K
---------
M
A
A
Q
G
T
A
G
R
F
V
F
P
R
P
M
T
-
D
R
P
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
D
--
N
G
TD-----
D
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
Q
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
-
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
A
-
T
---
A
D
L
G
V
S
-
V
R
P
R
W
P
L
A
E
L
-----
4
PsiBlast_PDB
85.50
62%
-55
- C2 -
-
4WQ5
1
TSAD_ECOLI
A:
[1-332]
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
--
N
Q
L
Y
S
Q
-
V
K
L
--
H
A
D
-
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
E
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
E
D
--
N
P
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
-
G
G
P
L
L
S
K
---------
M
A
A
Q
G
T
A
G
R
F
V
F
P
R
P
M
T
-
D
R
P
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
D
--
N
G
TD-----
D
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
Q
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
-
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
A
-
T
---
A
D
L
G
V
S
-
V
R
P
R
W
P
L
A
-------
34
HHSearch
84.91
62%
-52
- C2 -
-
3ZEU
1
TSAD_SALTY
E:
[1-336]
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
K
K
G
L
L
A
--
N
Q
L
Y
S
Q
-
V
K
L
--
H
A
D
-
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
E
D
--
N
P
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
----------
M
A
S
Q
G
T
A
G
R
F
V
F
P
R
P
M
T
D
R
P
-
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
S
N
G
G
D
-------
E
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
E
S
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
R
R
G
-
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
V
-
T
---
A
D
L
G
V
T
-
V
R
P
R
W
P
L
A
E
L
P
A
---
23
PsiBlast_CBE
84.68
62%
-53
- C2 -
-
4WQ5
1
TSAD_ECOLI
B:
[1-334]
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
--
N
Q
L
Y
S
Q
-
V
K
L
--
H
A
D
-
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
E
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
E
D
--
N
P
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
-
G
G
P
L
L
S
K
---------
M
A
A
Q
G
T
A
G
R
F
V
F
P
R
P
M
T
-
D
R
P
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
D
--
N
G
TD-----
D
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
Q
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
-
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
A
-
T
---
A
D
L
G
V
S
-
V
R
P
R
W
P
L
A
E
L
-----
1
PsiBlast_PDB
84.47
62%
-55
- C2 -
-
4YDU
2
TSAD_ECOLI
A:
[1-334]
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
--
N
Q
L
Y
S
Q
-
V
K
L
--
H
A
D
-
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
E
D
--
N
P
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
-
G
G
P
L
L
S
K
---------
M
A
A
Q
G
T
A
G
R
F
V
F
P
R
P
M
T
-
D
R
P
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
D
--
N
G
TD-----
D
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
Q
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
-
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
A
-
T
---
A
D
L
G
V
S
-
V
R
P
R
W
P
L
A
E
L
-----
24
PsiBlast_CBE
83.77
62%
-59
- C2 -
-
4WQ4
2
TSAD_ECOLI
B:
[1-334]
M
R
V
L
G
I
E
T
S
C
D
A
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
--
N
Q
L
Y
S
Q
-
V
K
L
--
H
A
D
-
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
-
L
A
P
M
L
E
D
--
N
P
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
-
G
G
P
L
L
S
K
---------
M
A
A
Q
G
T
A
G
R
F
V
F
P
R
P
M
T
-
D
R
P
G
----
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
D
--
N
G
TD-----
D
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
Q
-----
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
-
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
A
-
T
---
A
D
L
G
V
S
-
V
R
P
R
W
P
L
A
E
L
-----
53
Fugue
71.34
35%
-96
- C2 -
-
2IVN
2
KAE1_PYRAB
A:
[1-325]
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
S
E
D
-
K
V
L
A
--
N
V
F
D
T
L
------
T
T
E
-
K
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
-
E
I
T
K
M
F
G
-----
V
K
D
P
V
G
L
Y
V
S
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
-
G
G
P
K
V
E
K
---------
L
A
E
K
G
E
K
-
Y
I
E
L
P
Y
A
V
K
----
G
----
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
---
G
-------
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
-----
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
G
I
-
K
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
I
-
S
---
F
R
L
E
E
T
I
V
K
Q
K
F
R
T
D
E
V
E
I
V
W
H
11
PsiBlast_PDB
67.25
34%
-108
- C2 -
-
2VWB
1
KAE1B_METJA
A:
[1-322]
M
I
C
L
G
L
E
G
T
A
E
K
T
G
V
G
I
V
T
S
D
----
G
--
E
V
L
F
N
K
-
T
I
M
-------------
E
A
A
D
H
H
A
E
T
F
P
K
L
I
K
E
A
F
E
V
--
V
D
K
N
E
I
D
L
I
A
F
S
Q
G
P
G
L
G
P
S
L
R
V
T
A
T
V
A
R
T
L
S
L
T
L
K
K
P
I
I
G
V
N
H
C
I
A
H
I
-
E
I
G
K
L
T
T
--
E
A
-
E
D
P
-
L
T
L
Y
V
S
G
G
N
T
Q
V
-
I
A
Y
V
S
K
K
Y
R
V
F
G
E
T
L
D
I
A
V
G
N
C
L
D
Q
F
A
R
Y
V
N
L
P
H
P
-
G
G
P
Y
I
E
E
---------
L
A
R
K
G
K
K
L
V
---
D
L
P
Y
T
-
V
K
-
G
----
M
D
I
A
F
S
G
L
L
T
A
A
---
M
R
A
Y
-
D
A
-------
G
E
R
L
E
D
I
C
Y
S
L
Q
E
Y
A
F
S
M
L
T
E
I
T
E
R
A
L
A
H
-----
T
N
K
G
E
V
M
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
K
A
M
C
E
G
Q
N
V
-
D
F
Y
V
P
P
K
E
F
C
G
D
N
G
A
M
I
A
W
L
G
L
L
M
H
K
N
G
R
-
W
M
S
L
D
E
T
K
I
I
-
P
N
Y
R
T
D
M
V
E
V
N
----
7
PsiBlast_PDB
63.42
36%
-53
- C2 -
-
2IVN
2
KAE1_PYRAB
A:
[1-301]
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
V
L
A
--
N
V
F
D
T
----
L
--
T
T
E
-
K
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
G
V
--
K
D
P
----
V
G
L
Y
V
S
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
-
G
G
P
K
V
E
K
---------
L
A
E
K
G
E
K
Y
-
I
E
L
P
Y
A
V
---
K
-
G
----
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
---
S
G
-------
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
-----
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
G
I
-
K
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
----------------------------
8
PsiBlast_PDB
63.15
36%
-55
- C2 -
-
2IVO
-
KAE1_PYRAB
A:
[1-301]
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
V
L
A
--
N
V
F
D
T
----
L
--
T
T
E
-
K
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
G
V
--
K
D
P
----
V
G
L
Y
V
S
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
-
G
G
P
K
V
E
K
---------
L
A
E
K
G
E
K
Y
-
I
E
L
P
Y
A
V
---
K
-
G
----
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
---
S
G
-------
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
-----
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
G
I
-
K
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
----------------------------
25
PsiBlast_CBE
62.59
32%
-14
- C2 -
-
3WUH
1
QRI7_YEAST
B:
[11-372]
--
V
L
A
I
E
T
S
C
D
D
T
C
V
S
V
L
D
R
F
S
K
S
A
A
--
P
N
V
L
A
N
-
L
K
D
TL-----------
K
A
H
I
H
H
Q
A
R
I
G
P
L
T
E
R
A
L
I
E
S
N
A
R
-
E
G
I
D
L
I
C
V
T
R
G
P
G
M
P
G
S
L
S
G
G
L
D
F
A
K
G
L
A
V
A
W
N
K
P
L
I
G
V
H
H
M
L
G
H
L
-
L
I
P
R
M
G
T
NG
K
V
P
Q
F
P
F
V
S
L
L
V
S
G
G
H
T
T
F
V
L
S
R
A
I
D
D
H
E
I
L
C
D
T
I
D
I
A
V
G
D
S
L
D
K
C
G
R
E
L
G
F
K
----
G
T
M
I
A
R
E
M
E
K
F
INQD
I
N
D
Q
D
F
A
L
K
L
E
M
P
S
--------KRN
M
L
S
F
S
F
S
A
F
I
T
A
L
R
T
N
L
T
K
L
-
G
K
TEIQELP
E
R
E
I
R
S
I
A
Y
Q
V
Q
E
S
V
F
D
H
I
I
N
K
L
K
H
V
L
K
S
QPEKF
K
N
V
R
E
F
V
C
S
G
G
V
S
S
N
Q
R
L
R
T
K
L
E
T
E
L
-----F
N
F
Y
Y
P
P
M
D
L
C
S
D
N
S
I
M
I
G
W
A
G
I
E
I
W
E
S
L
R
L
V
---
S
D
L
D
I
C
-
P
I
R
Q
W
P
L
N
D
L
-----
9
PsiBlast_PDB
62.30
36%
-52
- C2 -
-
2IVP
1
KAE1_PYRAB
A:
[1-301]
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
V
L
A
--
N
V
F
D
T
----
L
--
T
T
E
-
K
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
G
V
--
K
D
P
----
V
G
L
Y
V
S
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
-
G
G
P
K
V
E
K
---------
L
A
E
K
G
E
K
Y
-
I
E
L
P
Y
A
V
---
K
-
G
----
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
---
S
G
-------
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
-----
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
G
I
-
K
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
----------------------------
13
PsiBlast_PDB
61.93
34%
0
- C- -
-
3EN9
-
KAE1B_METJA
A:
[6-345]
M
I
C
L
G
L
E
G
T
A
E
K
T
G
V
G
I
V
T
S
D
----
G
--
E
V
L
F
N
K
-
T
I
M
--
Y
K
P
P
K
Q
G
I
N
P
R
E
A
A
D
H
H
A
E
T
F
P
K
L
I
K
E
A
F
E
V
--
V
D
K
N
E
I
D
L
I
A
F
S
Q
G
P
G
L
G
P
S
L
R
V
T
A
T
V
A
R
T
L
S
L
T
L
K
K
P
I
I
G
V
N
H
C
I
A
H
I
-
E
I
G
K
L
T
T
--
E
A
-
E
D
P
-
L
T
L
Y
V
S
G
G
N
T
Q
V
-
I
A
Y
V
S
K
K
Y
R
V
F
G
E
T
L
D
I
A
V
G
N
C
L
D
Q
F
A
R
Y
V
N
L
P
H
P
-
G
G
P
Y
I
E
E
---------
L
A
R
K
G
K
K
L
V
---
D
L
P
Y
T
-
V
K
-
G
----
M
D
I
A
F
S
G
L
L
T
A
A
---
M
R
A
Y
-
D
A
-------
G
E
R
L
E
D
I
C
Y
S
L
Q
E
Y
A
F
S
M
L
T
E
I
T
E
R
A
L
A
H
-----
T
N
K
G
E
V
M
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
K
A
M
C
E
G
Q
N
V
-
D
F
Y
V
P
P
K
E
F
C
G
D
N
G
A
M
I
A
W
L
G
L
L
M
H
K
N
G
R
-
W
M
S
L
D
E
T
K
I
I
-
P
N
Y
R
T
D
M
V
E
V
N
----
29
PsiBlast_CBE
61.12
35%
-33
- C2 -
-
5JMV
1
KAE1B_METJA
C:
[6-306]
M
I
C
L
G
L
E
G
T
A
E
K
T
G
V
G
I
V
T
S
D
----
G
--
E
V
L
F
N
K
T
I
M
Y
----------
N
P
R
E
A
A
D
H
H
A
E
T
F
P
K
L
I
K
E
A
F
E
V
--
V
D
K
N
E
I
D
L
I
A
F
S
Q
G
P
G
L
G
P
S
L
R
V
T
A
T
V
A
R
T
L
S
L
T
L
K
K
P
I
I
G
V
N
H
C
I
A
H
I
-
E
I
G
K
L
T
T
--
E
A
-
E
D
P
-
L
T
L
Y
V
S
G
G
N
T
Q
V
-
I
A
Y
V
S
K
K
Y
R
V
F
G
E
T
L
D
I
A
V
G
N
C
L
D
Q
F
A
R
Y
V
N
L
P
H
P
-
G
G
P
Y
I
E
E
---------
L
A
R
K
G
K
K
L
V
---
D
L
P
Y
T
-
V
K
-
G
----
M
D
I
A
F
S
G
L
L
T
A
A
---
M
R
A
Y
-
D
A
-------
G
E
R
L
E
D
I
C
Y
S
L
Q
E
Y
A
F
S
M
L
T
E
I
T
E
R
A
L
A
H
-----
T
N
K
G
E
V
M
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
K
A
M
C
E
G
Q
N
V
-
D
F
Y
V
P
P
K
E
F
C
G
D
N
G
A
M
I
A
W
L
G
L
L
M
H
K
N
G
R
---------------------------
41
HHSearch
60.58
34%
-18
- C2 -
-
2IVN
2
KAE1_PYRAB
A:
[1-307]
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
S
E
D
-
K
V
L
A
N
V
F
D
T
L
T
T
-
E
K
G
--
G
------
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
-
E
I
T
K
M
F
G
--
V
---
K
D
P
V
G
L
Y
V
S
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
----------
L
A
E
K
G
E
K
Y
-
I
E
L
P
--
Y
A
-
V
K
-
G
----
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
G
-
K
Y
---------
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
-----
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
G
I
-
K
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
I
-
S
---
F
R
L
E
------------------
32
PsiBlast_CBE
60.56
34%
0
- C- -
-
3EN9
1
KAE1B_METJA
B:
[6-344]
M
I
C
L
G
L
E
G
T
A
E
K
T
G
V
G
I
V
T
S
D
----
G
--
E
V
L
F
N
K
-
T
I
M
--
Y
K
P
---
G
I
N
P
R
E
A
A
D
H
H
A
E
T
F
P
K
L
I
K
E
A
F
E
V
--
V
D
K
N
E
I
D
L
I
A
F
S
Q
G
P
G
L
G
P
S
L
R
V
T
A
T
V
A
R
T
L
S
L
T
L
K
K
P
I
I
G
V
N
H
C
I
A
H
I
-
E
I
G
K
L
T
T
--
E
A
-
E
D
P
-
L
T
L
Y
V
S
G
G
N
T
Q
V
-
I
A
Y
V
S
K
K
Y
R
V
F
G
E
T
L
D
I
A
V
G
N
C
L
D
Q
F
A
R
Y
V
N
L
P
H
P
-
G
G
P
Y
I
E
E
---------
L
A
R
K
G
K
K
L
V
---
D
L
P
Y
T
-
V
K
-
G
----
M
D
I
A
F
S
G
L
L
T
A
A
---
M
R
A
Y
-
D
A
-------
G
E
R
L
E
D
I
C
Y
S
L
Q
E
Y
A
F
S
M
L
T
E
I
T
E
R
A
L
A
H
-----
T
N
K
G
E
V
M
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
K
A
M
C
E
G
Q
N
V
-
D
F
Y
V
P
P
K
E
F
C
G
D
N
G
A
M
I
A
W
L
G
L
L
M
H
K
N
G
R
-
W
M
S
L
D
E
T
K
I
I
-
P
N
Y
R
T
D
M
V
E
V
N
----