@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VRL9: (2017-12-03 )
MTDQYQAFTQSPIGKFVVKNLGLPSPVVLERFESAQPVVKGAVLVGAAPSSVLSGAIAQVLSNIHADSYVGNNVALQQEAAKVGLNLRPFNAGDKESKFKAVVFDASGIQNSEQLNELYKFFNPIARQVATSGRVIVIGTTPETAKTIKQAIAQRALEGFIKSVGKEFKKGITAQVVYVDEGAAANLESTLRFLLSPRSAYVSGQVIRVSKADVVDVDWAKPLAGKTALVTGASRGIGEAIAHVLARDGAHVICLDVPQQQADLDRVAADIGGSTLAIDITAADAGEKIKAAAAKQGGLDIIVHNAGITRDKTLANMKPELWDLVININLSAAERINDYLLENDGLNANGRIVCVSSISGIAGNLGQTNYAASKAGVIGLVKFTAPILKNGITINAVAPGFIETQMTAAIPFAIREAGRRMNSMQQGGLPVDVAETIAWFASTASTGVNGNVVRVCGQSLLGA
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........--70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180-..---.---......190.......200.......210-..-.-.-...220.......230.......240.......250.......260....--.....270--........280.....---.-.-290...----.--..--.300.......310.......320.......330--.........340.......350.......360.......370.......380...-...-.-390........400.......410.......420.......430.......440.......450.......460.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MT
D
Q
Y
Q
A
F
T
QSP
I
G
K
F
V
V
K
NLGLP
S
P
V
V
L
E
R
FESAQPVVK
G
A
V
L
VGA
A
P
S
S
V
L
S
G
A
I
A
Q
V
L
S
N
IHADSY--VGN
N
V
A
L
Q
Q
E
A
A
KVGLNLRPFNAGDKES
K
F
K
A
V
V
F
DASGIQ
N
S
E
Q
L
N
E
L
Y
K
F
F
N
P
I
A
R
Q
VATSG
R
V
I
V
I
GTTP
E
T
A
K
T
I
K
Q
A
I
A
Q
R
A
L
E
G
F
I
K
S
V
G
K
E
F
K
KGI
T
A
Q
V
V
Y
VD---EG---A---AA
N
L
E
S
T
L
R
F
L
LSPRSAYVSG
Q
V
I
R
VSKA-
D
V
-
V
-D-VDWAKPLAGK
T
A
L
VTGASR
G
I
G
E
A
I
A
H
V
L
A
RDG
A
H
V
I
C
L
DV
P
Q
Q
--QA
D
L
--
D
R
V
A
A
DI---GG
S
T
L
A
I
D
I
T
AADAG
E
---
K
-
I
-
K
A
A
A
AK----Q--G
G
--
L
D
I
I
V
HNAGITRDK
T
L
ANMKP
E
L
W
D
L
V
I
N
I
NL----
S
A
A
E
R
I
N
D
Y
L
LENDGLNAN
G
R
I
V
C
V
SSI
S
G
I
AGNLGQTNYAASKA
G
V
I
G
L
V
K
F
T
A
-
P
I
L
-K-N-
G
I
T
I
NAVAP
G
F
I
E
T
Q
M
T
A
A
I
P
F
A
I
R
E
A
G
R
R
M
N
S
M
QQGGLP
V
D
V
A
E
T
I
A
W
F
A
S
TASTGVNG
N
V
V
R
V
C
G
Q
S
LLGA
24
PsiBlast_CBE
89.34
48%
-49
- C2 -
-
4FW8
2
?
B:
[20-454]
--------------
S
F
L
A
R
Q
L
G
-
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
---------
G
R
V
V
E
P
L
R
A
----------
A
L
E
K
D
Y
D
L
V
G
------------
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PDA
K
P
---
A
---
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
-
D
S
-
T
-
P
P
A
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
E
S
A
--
A
E
N
L
--
A
E
T
A
S
K
V
---
G
G
T
A
L
W
L
D
V
T
A
D
D
A
V
D
---
K
-
I
-
S
E
H
L
R
D
----
H
--
H
G
GK
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
----
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
-
P
G
L
-
A
A
K
-
G
I
T
I
N
A
V
A
P
G
F
I
E
T
Q
M
T
-
A
I
P
L
A
T
R
E
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
5
PsiBlast_PDB
89.16
48%
-49
- C2 -
-
3V1U
3
?
A:
[37-462]
-----------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
---------
G
R
V
V
E
P
L
R
A
----------
A
L
E
K
D
Y
D
L
V
G
-----------
A
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PDA
K
P
---
A
---
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
-
D
S
-
T
-
P
P
A
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
E
S
A
--
A
E
N
L
--
A
E
T
A
S
K
V
---
G
G
T
A
L
W
L
D
V
T
A
D
D
A
V
D
---
K
-
I
-
S
E
H
L
R
D
----
H
--
H
G
GK
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
----
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
-
P
G
L
-
A
A
K
-
G
I
T
I
N
A
V
A
P
G
F
I
E
T
Q
M
---
I
P
L
A
T
R
E
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
27
PsiBlast_CBE
89.11
49%
-47
- C2 -
-
3Q6I
2
?
B:
[12-446]
--------------
S
F
L
A
R
Q
L
G
-
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
---------
G
R
V
V
E
P
L
R
A
----------
A
L
E
K
D
Y
D
L
V
G
------------
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PDA
K
P
---
A
---
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
-
D
S
-
T
-
P
P
A
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
E
S
A
--
A
E
N
L
--
A
E
T
A
S
K
V
---
G
G
T
A
L
W
L
D
V
T
A
D
D
A
V
D
---
K
-
I
-
S
E
H
L
R
D
----
H
--
H
G
GK
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
----
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
-
P
G
L
-
A
A
K
-
G
I
T
I
N
A
V
A
P
G
F
I
E
T
Q
M
T
-
A
I
P
L
A
T
R
E
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
26
PsiBlast_CBE
88.50
49%
-49
- C2 -
-
3Q6I
1
?
C:
[21-446]
-----------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
---------
G
R
V
V
E
P
L
R
A
----------
A
L
E
K
D
Y
D
L
V
G
N
N
-------
R
W
A
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PDA
K
P
---
A
---
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
-
D
S
-
T
-
P
P
A
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
E
S
A
--
A
E
N
L
--
A
E
T
A
S
K
V
---
G
G
T
A
L
W
L
D
V
T
A
D
D
A
V
D
---
K
-
I
-
S
E
H
L
R
D
----
H
--
H
G
GK
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
----
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
-
P
G
L
-
A
A
K
-
G
I
T
I
N
A
V
A
P
G
F
I
E
-----
A
I
P
L
A
T
R
E
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
6
PsiBlast_PDB
88.09
49%
-48
- C2 -
-
3Q6I
2
?
A:
[12-446]
--------------
S
F
L
A
R
Q
L
G
V
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
---------
G
R
V
V
E
P
L
R
A
----------
A
L
E
K
D
Y
D
L
V
G
------------
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PDA
K
P
---
A
---
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
-
D
S
-
T
-
P
P
A
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
E
S
A
--
A
E
N
L
--
A
E
T
A
S
K
V
---
G
G
T
A
L
W
L
D
V
T
A
D
D
A
V
D
---
K
-
I
-
S
E
H
L
R
D
----
H
--
H
G
GK
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
----
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
-
P
G
L
-
A
A
K
-
G
I
T
I
N
A
V
A
P
G
F
I
E
T
Q
M
T
A
A
I
P
L
A
T
R
E
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
23
PsiBlast_CBE
87.94
48%
-46
- C2 -
-
4FW8
1
?
C:
[29-454]
-----------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
---------
G
R
V
V
E
P
L
R
A
----------
A
L
E
K
D
Y
D
L
V
G
N
N
-------
R
W
A
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PDA
K
P
---
A
---
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
-
D
S
-
T
-
P
P
A
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
E
S
A
--
A
E
N
L
--
A
E
T
A
S
K
V
---
G
G
T
A
L
W
L
D
V
T
A
D
D
A
V
D
---
K
-
I
-
S
E
H
L
R
D
----
H
--
H
G
GK
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
----
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
-
P
G
L
-
A
A
K
-
G
I
T
I
N
A
V
A
P
G
F
I
E
-----
A
I
P
L
A
T
R
E
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
25
PsiBlast_CBE
87.43
49%
-44
- C2 -
-
3Q6I
1
?
D:
[21-446]
-----------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
---------
G
R
V
V
E
P
L
R
A
----------
A
L
E
K
D
Y
D
L
V
G
------------
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PDA
K
P
---
A
---
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
-
D
S
-
T
-
P
P
A
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
E
S
-----
N
L
--
A
E
T
A
S
K
V
---
G
G
T
A
L
W
L
D
V
T
A
D
D
A
V
D
---
K
-
I
-
S
E
H
L
R
D
----
H
--
H
G
GK
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
----
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
-
P
G
L
-
A
A
K
-
G
I
T
I
N
A
V
A
P
G
F
I
E
T
-----
I
P
L
A
T
R
E
-
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
115
HHSearch
87.36
51%
-49
- C2 -
-
3Q6I
2
?
A:
[12-446]
--------------
S
F
L
A
R
Q
L
G
V
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
--
G
R
V
V
E
P
L
R
A
A
L
E
K
-
D
Y
D
L
V
--
G
--------------------------
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
---
P
D
AKP
A
---
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
-
D
S
T
P
-
P
-
A
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
E
S
A
--
A
E
N
L
--
A
E
T
A
S
K
V
---
G
G
T
A
L
W
L
D
V
T
A
D
D
A
V
D
---
K
-
I
-
S
E
H
L
R
D
H---
H
G-
G
K
--
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
----
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
-
P
G
L
A
A
-
K
-
G
I
T
I
N
A
V
A
P
G
F
I
E
T
Q
M
T
A
A
I
P
L
A
T
R
E
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
22
PsiBlast_CBE
87.07
48%
-48
- C2 -
-
4FW8
1
?
D:
[29-454]
-----------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
---------
G
R
V
V
E
P
L
R
A
----------
A
L
E
K
D
Y
D
L
V
G
------------
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PDA
K
P
---
A
---
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
-
D
S
-
T
-
P
P
A
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
E
S
-----
N
L
--
A
E
T
A
S
K
V
---
G
G
T
A
L
W
L
D
V
T
A
D
D
A
V
D
---
K
-
I
-
S
E
H
L
R
D
----
H
--
H
G
GK
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
----
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
-
P
G
L
-
A
A
K
-
G
I
T
I
N
A
V
A
P
G
F
I
E
T
-----
I
P
L
A
T
R
E
-
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
3
PsiBlast_PDB
87.07
48%
-45
- C2 -
-
4FW8
2
?
A:
[20-454]
--------------
S
F
L
A
R
Q
L
G
V
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
---------
G
R
V
V
E
P
L
R
A
----------
A
L
E
K
D
Y
D
L
V
G
------------
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PDA
K
P
---
A
---
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
-
D
S
-
T
-
P
P
A
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
E
S
A
--
A
E
N
L
--
A
E
T
A
S
K
V
---
G
G
T
A
L
W
L
D
V
T
A
D
D
A
V
D
---
K
-
I
-
S
E
H
L
R
D
----
H
--
H
G
GK
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
----
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
-
P
G
L
-
A
A
K
-
G
I
T
I
N
A
V
A
P
G
F
I
E
T
Q
M
T
A
A
I
P
L
A
T
R
E
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
114
HHSearch
86.62
51%
-44
- C2 -
-
3U0B
-
?
A:
[30-454]
------------------------
Q
P
E
T
L
R
R
Y
R
P
G
D
P
P
L
A
G
S
L
L
I
G
G
S
--
G
R
V
A
E
P
L
R
T
A
L
A
D
D
Y
N
L
V
S
--
N
N
I
G
-------------------
G
R
W
A
D
S
F
G
G
V
V
F
D
A
T
G
I
T
E
A
E
G
L
K
E
L
Y
T
F
F
T
P
L
L
R
N
L
A
P
C
A
R
V
V
V
V
G
T
T
P
A
E
A
G
S
V
H
A
Q
V
V
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
V
S
L
V
Y
L
S
---
A
D
---
A
KPG
A
T
G
L
E
S
T
M
R
F
I
L
S
A
K
S
A
Y
V
D
G
Q
V
F
R
V
G
A
A
-
D
S
-
T
P
P
-
A
D
W
D
K
P
L
D
G
K
V
A
V
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
T
V
V
A
I
D
V
D
G
A
--
A
E
D
L
--
K
R
V
A
D
K
V
---
G
G
T
A
L
T
L
D
V
T
A
D
D
A
V
D
---
K
-
I
-
T
A
H
V
T
E
H---
H
G-
G
K
--
V
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
E
K
R
W
D
A
V
I
A
V
N
L
----
L
A
P
Q
R
L
T
E
G
L
V
G
N
G
T
I
G
E
G
G
R
V
I
G
L
S
S
M
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
L
A
E
A
L
A
-
P
V
L
A
D
-
K
-
G
I
T
I
N
A
V
A
P
G
F
I
E
T
----------
R
E
V
G
R
R
L
N
S
L
F
Q
G
G
Q
P
V
D
V
A
E
L
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
T
I
R
V
C
G
Q
A
M
L
G
A
21
PsiBlast_CBE
80.10
48%
-47
- C2 -
-
3LLS
2
?
B:
[52-475]
-------------------------
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
---------
G
R
V
V
E
P
L
R
A
----------
A
L
E
K
D
Y
D
L
V
G
-----------
A
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PDA
K
P
---
A
---
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
-
D
S
-
T
-
P
P
A
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
E
S
A
--
A
E
N
L
--
A
E
T
A
S
K
V
---
G
G
T
A
L
W
L
D
V
T
A
D
D
A
V
D
---
K
-
I
-
S
E
H
L
R
D
----
H
--
H
G
GK
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
----
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
-
P
G
L
-
A
A
K
-
G
I
T
I
N
A
V
A
P
G
F
I
E
---------------
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
2
PsiBlast_PDB
78.89
48%
-43
- C2 -
-
3LLS
2
?
A:
[50-475]
-----------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
---------
G
R
V
V
E
P
L
R
A
----------
A
L
E
K
D
Y
D
L
V
G
N
-----------
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PDA
K
P
---
A
---
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
-
D
S
-
T
-
P
P
A
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
E
S
A
--
A
E
N
L
--
A
E
T
A
S
K
V
---
G
G
T
A
L
W
L
D
V
T
A
D
D
A
V
D
---
K
-
I
-
S
E
H
L
R
D
----
H
--
H
G
GK
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
----
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
-
P
G
L
-
A
A
K
-
G
I
T
I
N
A
V
A
P
G
F
I
E
---------------
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
4
PsiBlast_PDB
78.15
48%
-
- C2 -
-
3V1T
-
?
C:
[29-454]
-----------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
---------
G
R
V
V
E
P
L
R
A
----------
A
L
E
K
D
Y
D
L
V
-------------
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PDA
K
P
---
A
---
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
-
D
S
-
T
-
P
P
A
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
E
S
A
--
A
E
N
L
--
A
E
T
A
S
K
V
---
G
G
T
A
L
W
L
D
V
T
A
D
D
A
V
D
---
K
-
I
-
S
E
H
L
R
D
----
H
--
H
G
GK
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
----
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
-
P
G
L
-
A
A
K
-
G
I
T
I
N
A
V
A
P
G
F
I
E
T
----------
R
E
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
1
PsiBlast_PDB
77.75
49%
5
- C2 -
-
3U0B
-
?
A:
[30-454]
------------------------
Q
P
E
T
L
R
R
Y
R
P
G
D
P
P
L
A
G
S
L
L
I
G
G
------
S
G
R
V
A
E
P
L
R
T
A
L
A
D
D
Y
N
L
V
S
N
N
I
G
-----------------
G
R
W
A
D
S
F
G
G
V
V
F
D
A
T
G
I
T
E
A
E
G
L
K
E
L
Y
T
F
F
T
P
L
L
R
N
L
A
P
C
A
R
V
V
V
V
G
T
T
P
A
E
A
G
S
V
H
A
Q
V
V
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
V
S
L
V
Y
L
S
---
A
D
---
A
KPG
A
T
G
L
E
S
T
M
R
F
I
L
S
A
K
S
A
Y
V
D
G
Q
V
F
R
V
G
A
A
-
D
S
-
T
-
P
P
A
D
W
D
K
P
L
D
G
K
V
A
V
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
T
V
V
A
I
D
V
D
G
A
--
A
E
D
L
--
K
R
V
A
D
K
V
---
G
G
T
A
L
T
L
D
V
T
A
D
D
A
V
D
---
K
-
I
-
T
A
H
V
T
E
----
H
--
H
G
GK
V
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
E
K
R
W
D
A
V
I
A
V
N
L
----
L
A
P
Q
R
L
T
E
G
L
V
G
N
G
T
I
G
E
G
G
R
V
I
G
L
S
S
M
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
L
A
E
A
L
A
-
P
V
L
-
A
-
D
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
----------
R
E
V
G
R
R
L
N
S
L
F
Q
G
G
Q
P
V
D
V
A
E
L
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
T
I
R
V
C
G
Q
A
M
L
G
A
134
Fugue
75.58
49%
-39
- C2 -
-
3LLS
2
?
A:
[50-475]
-----------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
------------------------------
V
E
P
L
R
A
A
L
E
K
D
Y
D
L
V
G
N
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
---
P
D
---
A
KPA
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
D
S
T
-
P
-
P
-
A
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
E
S
A
--
A
E
N
L
--
A
E
T
A
S
K
V
---
G
G
T
A
L
W
L
D
V
T
A
D
D
A
V
D
---
K
-
I
-
S
E
H
L
R
D
----
H
HG
G
K
--
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
----
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
-
P
G
L
-
A
A
K
-
G
I
T
I
N
A
V
A
P
G
F
I
E
R
R
L
N
---------------
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
47
PsiBlast_CBE
56.65
37%
-60
- C2 -
-
4NBU
1
?
C:
[11-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
F
-
N
E
--
A
A
G
K
--
E
A
V
E
A
N
P
---
G
V
V
F
I
R
V
D
V
S
D
R
E
S
V
H
---
R
L
V
-
E
N
V
A
E
R
----
F
--
G
K
--
I
D
I
L
I
N
N
A
G
I
T
R
D
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
----
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
G
K
G
K
I
I
N
T
S
S
V
T
G
T
Y
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
-
K
E
L
A
R
-
K
-
G
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
V
A
E
V
P
E
K
V
I
E
K
M
K
A
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
M
--
14
PsiBlast_PDB
55.97
41%
-44
- C2 -
-
3U09
-
FABG_VIBCH
A:
[10-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S
E
S
G
A
Q
A
I
S
--
D
Y
L
G
D
N
-----
G
K
G
M
A
L
N
V
T
N
P
E
S
I
E
---
A
-
V
L
K
A
I
T
D
E
----
F
--
G
G
--
V
D
I
L
V
N
N
A
D
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
----
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
-
S
-
R
-
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
N
D
E
Q
R
T
A
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
16
PsiBlast_PDB
55.72
37%
-59
- C2 -
-
4NBU
1
?
A:
[11-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
F
-
N
E
--
A
A
G
K
--
E
A
V
E
A
N
P
---
G
V
V
F
I
R
V
D
V
S
D
R
E
S
V
H
---
R
L
V
-
E
N
V
A
E
R
----
F
--
G
K
--
I
D
I
L
I
N
N
A
G
I
T
R
D
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
----
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
G
K
G
K
I
I
N
T
S
S
V
T
G
T
Y
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
-
K
E
L
A
R
-
K
-
G
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
V
A
E
V
P
E
K
V
I
E
K
M
K
A
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
M
--
35
PsiBlast_CBE
55.23
41%
-46
- C2 -
-
3RRO
5
FABG_VIBCH
B:
[10-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S
E
S
GA
Q
A
I
S
--
D
Y
L
G
D
N
-----
G
K
G
M
A
L
N
V
T
N
P
E
S
I
E
---
A
-
V
L
K
A
I
T
D
E
----
F
--
G
G
--
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
----
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
-
S
-
R
-
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
N
D
E
Q
R
T
A
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
10
PsiBlast_PDB
54.67
41%
-43
- C2 -
-
3RRO
5
FABG_VIBCH
A:
[10-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S
E
S
G
A
Q
A
I
S
--
D
Y
L
G
D
N
-----
G
K
G
M
A
L
N
V
T
N
P
E
S
I
E
---
A
-
V
L
K
A
I
T
D
E
----
F
--
G
G
--
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
----
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
-
S
-
R
-
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
N
D
E
Q
R
T
A
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
11
PsiBlast_PDB
54.55
41%
-44
- C2 -
-
4I08
2
FABG_VIBCH
A:
[10-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S
E
S
G
A
Q
A
I
S
--
D
Y
L
G
D
N
-----
G
K
G
M
A
L
N
V
T
N
P
E
S
I
E
---
A
-
V
L
K
A
I
T
D
E
----
F
--
G
G
--
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
----
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
-
S
-
R
-
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
----
N
D
E
Q
R
T
A
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
61
PsiBlast_CBE
52.97
35%
-17
- C2 -
-
2PNF
3
FABG_AQUAE
B:
[5-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
G
K
V
S
L
V
T
G
S
T
R
G
I
G
R
A
I
A
E
K
L
A
S
A
G
S
T
V
I
I
T
G
T
S
G
E
--
R
A
K
A
VA
E
E
I
A
N
K
Y
---
G
V
K
A
H
G
V
E
M
N
L
L
S
E
-
E
---
S
-
I
-
N
K
A
F
E
E
IYNL
V
--
D
G
--
I
D
I
L
V
N
N
A
G
I
T
R
D
K
L
F
L
R
M
S
L
L
D
W
E
E
V
L
K
V
N
L
----
T
G
T
F
L
V
T
Q
N
S
L
R
K
M
I
K
Q
R
W
G
R
I
V
N
I
S
S
V
V
G
F
T
G
N
V
G
Q
V
N
Y
S
T
T
K
A
G
L
I
G
F
T
K
S
L
A
-
K
E
L
-
A
P
R
-
N
V
L
V
N
A
V
A
P
G
F
I
E
T
D
M
T
A
V
L
S
E
E
I
K
Q
K
Y
K
E
Q
I
P
L
G
R
F
G
S
P
E
E
V
A
N
V
V
L
F
L
C
S
E
L
A
S
Y
I
T
G
E
V
I
H
V
N
G
------
62
PsiBlast_CBE
50.23
35%
-19
- C2 -
-
2PNF
3
FABG_AQUAE
A:
[5-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
G
K
V
S
L
V
T
G
S
T
R
G
I
G
R
A
I
A
E
K
L
A
S
A
G
S
T
V
I
I
T
G
T
S
G
E
--
R
A
K
A
V
A
E
E
I
A
N
K
Y
---
G
V
K
A
H
G
V
E
M
N
L
L
S
E
-
E
---
S
-
I
-
N
K
A
F
E
E
I
Y
N
L
V
--
D
G
--
I
D
I
L
V
N
N
A
G
I
T
R
D
K
L
F
L
R
M
S
L
L
D
W
E
E
V
L
K
V
N
L
----
T
G
T
F
L
V
T
Q
N
S
L
R
K
M
I
K
Q
R
W
G
R
I
V
N
I
S
S
V
V
G
F
T
G
N
V
G
Q
V
N
Y
S
T
T
K
A
G
L
I
G
F
T
K
S
L
A
-
K
E
L
-
A
P
R
-
N
V
L
V
N
A
V
A
P
G
F
I
E
T
D
M
T
A
V
L
S
E
E
I
K
Q
K
Y
K
E
Q
I
P
L
G
R
F
G
S
P
E
E
V
A
N
V
V
L
F
L
C
S
E
L
A
S
Y
I
T
G
E
V
I
H
V
N
G
------
50
PsiBlast_CBE
49.40
39%
-7
- C2 -
-
3SJ7
3
?
A:
[11-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
A
L
V
T
G
A
S
R
G
I
G
R
S
I
A
L
Q
L
A
E
E
G
Y
N
V
-
A
V
N
Y
A
G
S
--
K
E
K
A
--
E
A
V
V
E
E
I
K
A
K
G
V
D
S
F
A
I
Q
A
N
V
A
D
A
D
E
V
K
A
M
-
I
-
K
E
V
V
S
Q
----
F
--
G
S
--
L
D
V
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
Q
E
W
D
D
V
I
D
T
N
L
K
G
V
F
N
C
I
Q
K
A
T
P
Q
M
L
R
Q
----
R
S
G
A
I
I
N
L
S
S
V
V
G
A
V
G
N
P
G
Q
A
N
Y
V
A
T
K
A
G
V
I
G
L
T
K
S
A
A
-
R
E
L
A
S
-
R
-
G
I
T
V
N
A
V
A
P
G
F
I
V
S
D
M
T
----
D
E
L
K
E
Q
M
L
T
Q
I
P
L
A
R
F
G
Q
D
T
D
I
A
N
T
V
A
F
L
A
S
D
K
A
K
Y
I
T
G
Q
T
I
H
V
N
G
------