@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TZJ8: (2017-12-16 )
MLGANQKHKNYYEGPKVIVTWALGHLLGLKMPEDLNKEWQSWQMDTLPMIPKKLGIKPLPKTGHQLKAIKQLAQRKDVSEAVIATDAGREGELVARWILEYVHFNKPVKRLWISSQTDKAIKTGFKQLRPAKEYDALYESALARAKADWLVGLNVTRALTVKYADNLSAGRVQTPTLALVRDQEKKIEQFRPQTYFTITLQAGKEQAKMLQKNQFALKTQEEAQKLVQLISTSKGTVTEVQEKLKTESAPLPYDLTEIQREANQRYGYSAKKTLSLVQSLYETHKIVTYPRTDSKYLTNDMKSTMKERLQAVSDFAPEVKQYLKNGAIVQQTKVFQDSKVTDHHALLPTENRARYEKLSNEERKIYQMIVSRFLGLFAQPHKVSQTKVTVEFGKERFIFRQNRVVQAGWKGETETETETVKWEKGMRINPDFAIKKELSAPPKPLSEASLLGQMEKYSLGTPATRAEIIEKLIKSELMERTPQGLQVSPKGKQLLVLVNPSLVTPDLTESWEKDLEAIAAGKKQAGTFLNGIEKETKRLVNEIKSSKQEYQDFSITQKKCPECGANLREKNTRDGKIYVCTNSDCNYRRRKDPKVSNHRCPQCHRKMEIIEGKNGAYFRCKYDGTTEKLLDKKEQKKKMTKHEERRLLKKYAQAEEPEESPLAAALKAAMKK
Atome Classification :
(20 SA)
-------------------------------------------.........10...-.....20........---30......-..40-..-------.......50-..---------....--.----------.60----..----.......70........80........90........100..--------.---..---..--110.......120.......130.....-..140.......150.......160----...---------.---------....170.......180.......190.....----.----.200..-----------...-..--210--------------------..--.....220---------.......230.-.......240.......250.......260.......270.......280..-------.-------....290.......300.--.......310--.---.....-.320.......330.......340.......------350---..---.-----....360---.......370.......380.......390----.......400..--..----...--------410-.-----.....-----------.--------..420.......430.......-----------.440..-.....450...-----------------...-----------------.460.......470.......480...-.....490.......---500-.---........510.......520.......530.......540...-..-.-.-550------.........560.......570.......580.......590.......600.......610....-...620.......630.......640.......650.......660.......670
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------------------------MLGANQKHKNYYEG-
P
K
V
I
V
T
W
A
L
G
H
L
LGL---KM
P
E
D
L
N
K
-
E
W
Q
--SW-------QMDTLPMI
P
-
K
K---------LGIK--P----------LP-----KT----G
H
Q
L
K
A
I
K
Q
L
A
Q
RKDV
S
E
A
V
I
ATDAGRE
G
E
L
V
A
R
W
I
L
E
Y
V
HF--------N---
K
P
---
V
K
--
R
LWISSQT
D
K
A
I
K
T
G
F
K
QLR
P
A
K
E
Y
D
A
L
-
Y
E
S
A
L
A
R
AKA
D
W
L
V
GLN
V
T
R
A
L
T
V
-----
K
YA---------D---------NLSAGRVQT
P
T
L
A
L
VR
D
Q
E
K
K
I
E
Q
FRPQ
T
Y
F
T
----
I
----
T
L
QA
G
K
-----------
E
Q
A
-
K
M
--
L
Q
K
--------------------
N
Q--FALK
T
Q
E
E
---------
A
Q
K
L
V
Q
L
I
-ST-SKG
T
V
T
E
V
Q
E
K
LKTESAPLP
Y
D
L
T
E
I
Q
R
E
A
N
Q
RYGY
S
A
K
K
T
L
S
L
V
Q
S
L
Y
E
TH-------
K
-------
I
V
TYPRTD
S
K
Y
L
T
N
D
M
-
K
--
S
T
M
K
E
R
L
Q
A
V
--
S
---
D
F
A
P
E
-
V
K
Q
Y
L
KNG
A
I
V
Q
Q
T
K
VFQDSKVTDHHALLPT------E
N
R
---
A
R
---
Y
-----
E
K
LS
N
E
E
---
R
K
I
Y
Q
M
I
V
S
R
F
L
G
L
FAQPHKVS
Q
T
K
V
T
V
E
F----GK
E
R
F
I
F
RQN
R
V
--
V
Q----AGW--------K---G-----ETETE-----------T--------
E
T
V
K
WEKGMRINP-DFA
I
K
K
EL-----------SAPPKP-
L
S
E
A
S
L
L
G
Q
M
E
-----------------
K
YS-----------------LGTP
A
T
R
A
E
I
I
E
K
L
I
K
S
E
L
M
E
RT-PQ
G
-
L
Q
VSPKG
K
Q
L
L
V
L
VN---P---S---LVTPD
L
T
E
S
W
E
K
D
L
E
A
I
AAGK
K
Q
A
G
T
F
L
N
G
I
E
K
E
T
K
R
L
V
N
E
I
K
S
-
S
K
-
Q
-
E
-
Y
--------
Q
DFS
I
T
Q
K
K
C
P
ECGANLREKNTRD
G
K
I
Y
V
C
TNSDCNYRRRKDPKVSNHR
C
P
Q
C
H
R
K
M
E
I
I
EGKNG
A
-
Y
F
R
C
K
YDG
T
T
E
K
L
L
D
K
K
E
Q
K
K
K
M
T
K
H
E
E
R
R
L
L
K
K
Y
A
QAEEPEES
P
L
A
A
A
L
K
A
A
MKK
6
PsiBlast_PDB
96.90
30%
0
- C- -
-
2O5E
1
TOP3_ECOLI
A:
[37-634]
-------------------------------------------------------------
V
V
T
W
C
I
G
H
L
L
E
Q
---
A
Q
P
D
A
Y
D
S
-
R
Y
A
--
R
W
-------
N
L
A
D
L
P
I
V
P
-
E
K
---------
W
Q
L
Q
--
P
----------
R
P
-----
S
V
----
T
K
Q
L
N
V
I
K
R
F
L
H
--
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
----
R
---
Q
Q
---
V
Q
--
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
-
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
---------
V
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
----
V
T
P
A
D
E
-----------
R
F
T
-
A
I
--
W
Q
P
--------------------
S
E
--
A
C
E
P
Y
Q
D
E
EGRLLHR
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
T
H
-------
K
-------
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
-
F
--
A
G
R
H
A
V
M
N
A
I
--
S
---
V
H
A
P
D
L
L
P
Q
P
V
V
D
P
D
I
--
R
N
R
C
W
D
D
K
K
V
D
A
H
H
A
I
I
P
T
------
A
-
R
---
S
S
---
A
-----
I
N
L
T
E
N
E
---
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
----
A
G
W
--------
R
TLL
G
-----
S
K
E
R
D
-----------
E
--------
E
N
----
D
G
T
P
L
-
P
-
V
V
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
-
F
T
D
A
T
L
L
S
A
M
T
-----------------
G
I
A
RFVQD
K
D
L
K
K
I
LRATDG
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
-
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
---
E
---
M
---
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
D
Q
A
K
R
-
T
------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
96.90
30%
0
- C- -
-
2O5C
1
TOP3_ECOLI
A:
[37-634]
-------------------------------------------------------------
V
V
T
W
C
I
G
H
L
L
E
Q
---
A
Q
P
D
A
Y
D
S
-
R
Y
A
--
R
W
-------
N
L
A
D
L
P
I
V
P
-
E
K
---------
W
Q
L
Q
--
P
----------
R
P
-----
S
V
----
T
K
Q
L
N
V
I
K
R
F
L
H
--
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
----
R
---
Q
Q
---
V
Q
--
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
-
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
---------
V
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
----
V
T
P
A
D
E
-----------
R
F
T
-
A
I
--
W
Q
P
--------------------
S
E
--
A
C
E
P
Y
Q
D
E
EGRLLHR
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
T
H
-------
K
-------
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
-
F
--
A
G
R
H
A
V
M
N
A
I
--
S
---
V
H
A
P
D
L
L
P
Q
P
V
V
D
P
D
I
--
R
N
R
C
W
D
D
K
K
V
D
A
H
H
A
I
I
P
T
------
A
-
R
---
S
S
---
A
-----
I
N
L
T
E
N
E
---
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
----
A
G
W
--------
R
TLL
G
-----
S
K
E
R
D
-----------
E
--------
E
N
----
D
G
T
P
L
-
P
-
V
V
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
-
F
T
D
A
T
L
L
S
A
M
T
-----------------
G
I
A
RFVQD
K
D
L
K
K
I
LRATDG
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
-
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
---
E
---
M
---
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
D
Q
A
K
R
-
T
------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
96.90
30%
0
- C- -
-
2O54
1
TOP3_ECOLI
A:
[37-637]
-------------------------------------------------------------
V
V
T
W
C
I
G
H
L
L
E
Q
---
A
Q
P
D
A
Y
D
S
-
R
Y
A
--
R
W
-------
N
L
A
D
L
P
I
V
P
-
E
K
---------
W
Q
L
Q
--
P
----------
R
P
-----
S
V
----
T
K
Q
L
N
V
I
K
R
F
L
H
--
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
----
R
---
Q
Q
---
V
Q
--
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
-
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
---------
V
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
----
V
T
P
A
D
E
-----------
R
F
T
-
A
I
--
W
Q
P
--------------------
S
E
--
A
C
E
P
Y
Q
D
E
EGRLLH
R
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
T
H
-------
K
-------
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
-
F
--
A
G
R
H
A
V
M
N
A
I
--
S
---
V
H
A
P
D
L
L
P
Q
P
V
V
D
P
D
I
--
R
N
R
C
W
D
D
K
K
V
D
A
H
H
A
I
I
P
T
------
A
-
R
---
S
S
---
A
-----
I
N
L
T
E
N
E
---
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
----
A
G
W
--------
R
TLL
G
-----
S
K
E
R
D
-----------
E
--------
E
N
----
D
G
T
P
L
-
P
-
V
V
A
K
G
D
E
L
L
CE
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
-
F
T
D
A
T
L
L
S
A
M
T
-----------------
G
I
A
RFVQD
K
D
L
K
K
I
L
R
A
T
DG
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
-
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
---
E
---
M
---
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
D
Q
A
K
R
-
T
------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
96.90
30%
0
- C- -
-
2O19
1
TOP3_ECOLI
A:
[37-637]
-------------------------------------------------------------
V
V
T
W
C
I
G
H
L
L
E
Q
---
A
Q
P
D
A
Y
D
S
-
R
Y
A
--
R
W
-------
N
L
A
D
L
P
I
V
P
-
E
K
---------
W
Q
L
Q
--
P
----------
R
P
-----
S
V
----
T
K
Q
L
N
V
I
K
R
F
L
H
--
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
----
R
---
Q
Q
---
V
Q
--
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
-
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
---------
V
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
----
V
T
P
A
D
E
-----------
R
F
T
-
A
I
--
W
Q
P
--------------------
S
E
--
A
C
E
P
Y
Q
D
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
T
H
-------
K
-------
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
-
F
--
A
G
R
H
A
V
M
N
A
I
--
S
---
V
H
A
P
D
L
L
P
Q
P
V
V
D
P
D
I
--
R
N
R
C
W
D
D
K
K
V
D
A
H
H
A
I
I
P
T
------
A
-
R
---
S
S
---
A
-----
I
N
L
T
E
N
E
---
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
----
A
G
W
--------
R
TLL
G
-----
S
K
E
R
D
-----------
E
--------
E
N
----
D
G
T
P
L
-
P
-
V
V
A
K
G
D
E
L
L
CE
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
-
F
T
D
A
T
L
L
S
A
M
T
-----------------
G
I
A
RFVQD
K
D
L
K
K
I
L
R
A
T
DG
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
-
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
---
E
---
M
---
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
D
Q
A
K
R
-
T
------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
94.88
30%
0
- C- -
-
2O59
1
TOP3_ECOLI
A:
[37-641]
-------------------------------------------------------------
V
V
T
W
C
I
G
H
L
L
E
Q
---
A
Q
P
D
A
Y
D
S
-
R
Y
A
--
R
W
-------
N
L
A
D
L
P
I
V
P
-
E
K
---------
W
Q
L
Q
--
P
----------
R
P
-----
S
V
----
T
K
Q
L
N
V
I
K
R
F
L
H
--
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
----
R
---
Q
Q
---
V
Q
--
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
-
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
---------
V
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
----
V
T
P
A
D
E
-----------
R
F
T
-
A
I
--
W
Q
P
--------------------
S
----
C
E
P
Y
Q
D
E
EGRLLH
R
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
T
H
-------
K
-------
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
-
F
--
A
G
R
H
A
V
M
N
A
I
--
S
---
V
H
A
P
D
L
L
P
Q
P
V
V
D
P
D
I
--
R
N
R
C
W
D
D
K
K
V
D
A
H
H
A
I
I
P
T
------
A
-
R
---
S
S
---
A
-----
I
N
L
T
E
N
E
---
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
----
A
G
W
--------
R
TLL
G
-----
S
K
------------------------
N
----
D
G
T
P
L
-
P
-
V
V
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
-
F
T
D
A
T
L
L
S
A
M
T
-----------------
G
I
A
RFVQD
K
D
L
K
K
I
L
R
A
T
DG
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
-
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
---
E
---
M
---
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
D
Q
A
K
R
-
T
------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
78.27
30%
36
- C2 -
-
1I7D
1
TOP3_ECOLI
A:
[37-609]
-------------------------------------------------------------
V
V
T
W
C
I
G
H
L
L
E
Q
---
A
Q
P
D
A
Y
D
S
-
R
Y
A
--
R
W
-------
N
L
A
D
L
P
I
V
P
-
E
K
---------
W
Q
L
Q
--
P
----------
R
P
-----
S
V
----
T
K
Q
L
N
V
I
K
R
F
L
H
--
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
----
R
---
Q
Q
---
V
Q
--
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
-
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
---------
V
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
----
V
T
P
A
D
E
-----------
R
F
T
-
A
I
--
W
Q
P
--------------------
S
E
--
A
C
E
P
Y
Q
D
E
EGRLLH
R
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
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S
Y
N
D
K
R
E
S
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S
A
P
L
P
F
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L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
T
H
-------
K
-------
L
I
T
F
P
R
S
D
C
R
Y
L
P
E
E
H
-
F
--
A
G
R
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A
V
M
N
A
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--
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---
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H
A
P
D
L
L
P
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V
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D
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--
R
N
R
C
W
D
D
K
K
V
D
A
H
H
A
I
I
P
T
------
A
-
R
---
S
S
---
A
-----
I
N
L
T
E
N
E
---
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
----
A
G
W
--------
R
TLL
G
-----
S
K
E
R
D
-----------
E
--------
E
N
----
D
G
T
P
L
-
P
-
V
V
A
K
G
D
E
L
L
CE
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
-
F
T
D
A
T
L
L
S
A
M
T
-----------------
G
I
A
RFVQD
K
D
L
K
K
I
L
R
A
T
DG
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
-
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
---
E
---
M
---
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
D
Q
A
K
R
-
T
------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
74.90
30%
56
- C2 -
-
1I7D
1
TOP3_ECOLI
A:
[25-620]
-------------------------------------------------
K
G
D
G
F
I
E
C
G
N
G
Q
V
V
T
W
C
I
G
H
L
L
E
Q
---
A
Q
P
D
A
Y
D
S
-
R
Y
A
--
R
W
-------
N
L
A
D
L
P
I
V
P
-
E
K
---------
W
Q
L
Q
--
P
----------
R
P
-----
S
V
----
T
K
Q
L
N
V
I
K
R
F
L
H
E
A
--
S
E
I
V
H
A
G
D
P
D
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Q
L
L
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D
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V
L
D
Y
L
Q
L
A
P
E
K
----
R
---
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Q
---
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Q
--
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
-
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
-----
L
G
R
N
A
GYQ----
G
---------
V
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
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E
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N
F
V
A
K
D
F
F
E
----
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----
K
A
H
I
V
T
PAD
E
R
------
F
T
A
-
I
W
--
Q
P
S
EACEPYQD------------
E
E
--
G
R
L
L
H
R
P
L
---------
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
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T
S
Y
N
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K
R
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S
E
S
A
P
L
P
F
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L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
T
H
-------
K
-------
L
I
T
F
P
R
S
D
C
R
Y
L
P
E
E
H
-
F
--
A
G
R
H
A
V
M
N
A
I
--
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A
P
D
L
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L
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Q
--
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D
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R
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R
C
W
D
D
K
K
V
D
A
H
H
A
I
I
P
T
------
A
R
S
---
S
A
---------
I
N
L
T
E
N
E
---
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
----
A
G
W
--------
R
---
T
-----
L
L
G
S
K
-----------
E
RDEENDGT
P
L
P
V
V
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
-----------
T
Q
P
P
R
H
-
F
T
D
A
T
L
L
S
A
M
T
G
IARFVQD
K
D
L
K
K
I
L
R
A
T
D
G
-----------------
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
-
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
---
E
---
M
---
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
D
Q
A
K
R
-
T
---------------
P
V
R
Q
F
R
G
I
V
A
P
----------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
74.35
30%
35
- C2 -
-
1D6M
-
TOP3_ECOLI
A:
[37-609]
-------------------------------------------------------------
V
V
T
W
C
I
G
H
L
L
E
Q
---
A
Q
P
D
A
Y
D
S
-
R
Y
A
--
R
W
-------
N
L
A
D
L
P
I
V
P
-
E
K
---------
W
Q
L
Q
--
P
----------
R
P
-----
S
V
----
T
K
Q
L
N
V
I
K
R
F
L
H
--
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
----
R
---
Q
Q
---
V
Q
--
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
-
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G---------------
G
---------
V
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
----
V
T
P
A
D
E
-----------
R
F
T
-
A
I
--
W
Q
P
--------------------
S
E
--
A
C
E
P
Y
Q
D
E
EGRLLH
R
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
T
H
-------
K
-------
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
-
F
--
A
G
R
H
A
V
M
N
A
I
--
S
---
V
H
A
P
D
L
L
P
Q
P
V
V
D
P
D
I
--
R
N
R
C
W
D
D
K
K
V
D
A
H
H
A
I
I
P
T
------
A
-
R
---
S
S
---
A
-----
I
N
L
T
E
N
E
---
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
----
A
G
W
--------
R
TLL
G
-----
S
K
E
R
D
-----------
E
--------
E
N
----
D
G
T
P
L
-
P
-
V
V
A
K
G
D
E
L
LCE
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
-
F
T
D
A
T
L
L
S
A
M
T
-----------------
G
I
A
RFVQD
K
D
L
K
K
I
LRATDG
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
-
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
---
E
---
M
---
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
D
Q
A
K
R
-
T
------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
71.90
24%
40
- C2 -
-
4CGY
-
TOP3A_HUMAN
A:
[84-640]
-----------------------------------------------------------
T
M
V
M
T
S
V
S
G
H
L
L
A
H
---
D
F
Q
M
Q
F
-----
R
--
K
W
-------
Q
-
S
C
N
P
L
V
L
------------
F
E
A
E
--
I
----------
E
K
-----
Y
C
P
ENF
V
D
I
K
K
T
L
E
R
E
T
R
Q
C
--
Q
A
L
V
I
W
T
D
C
D
R
E
G
E
N
I
G
F
E
I
I
H
V
C
K
A
--------
V
KPN
L
Q
---
V
L
--
R
A
R
F
S
E
I
T
P
H
A
V
R
T
A
C
E
N
L
T
E
P
D
Q
--
R
V
-
S
D
A
V
D
V
R
Q
E
L
D
L
R
I
G
A
A
F
T
R
F
Q
T
L
-----
R
L
Q
R
I
F
PEVLAE
Q
---------
L
I
S
Y
G
S
C
Q
F
P
T
L
G
F
V
V
E
R
F
K
A
I
Q
A
F
V
P
E
I
F
H
R
----
I
----
K
V
T
H
D
H
KD
G
I
-------
V
E
F
-
N
W
--
K
-----------------------
R
--
H
R
L
F
N
H
T
A
---------
C
L
V
L
Y
Q
L
C
-
V
E
D
P
M
A
T
V
V
E
V
R
S
K
P
K
S
K
W
R
P
Q
A
L
D
T
V
E
L
E
K
L
A
S
R
K
L
R
I
N
A
K
E
T
M
R
I
A
E
K
L
Y
T
Q
--------
G
-------
Y
I
S
Y
P
R
T
E
T
N
I
F
P
R
D
L
-
N
--
L
T
V
--
L
V
E
Q
Q
--
T
PDP
R
W
G
A
F
-
A
Q
S
I
L
E
R
G
G
--
P
T
P
R
-
N
G
N
K
S
D
Q
A
H
P
P
I
H
P
T
------
K
Y
T
---
N
-----------
N
L
Q
G
D
E
---
Q
R
L
Y
E
F
I
V
R
H
F
L
A
C
C
S
Q
D
A
Q
G
Q
E
T
T
V
E
I
D
I
----
A
Q
E
R
F
V
A
H
G
L
M
I
--
L
A
----
R
N
Y
--------
L
---
D
-----
V
Y
P
Y
D
-----------
H
W
S
D
K----
I
L
P
V
Y
E
Q
G
S
H
F
Q
P
S
T
V
E
M
V
D
G
E
-----------
T
S
P
P
K
L
-
L
T
E
A
D
L
I
A
L
M
E
-----------------
K
H
G
-----------------
I
G
T
D
A
T
H
A
E
H
I
E
T
I
K
A
R
M
Y
V
G
L
T
P
D
K
R
-
F
L
P
G
H
L
G
M
G
L
V
E
G
Y
D
---
S
MGY
E
---
M
S
K
P
D
L
R
A
E
L
E
A
D
L
K
L
I
C
D
G
K
K
D
K
F
V
V
L
R
Q
Q
V
Q
K
Y
K
Q
V
F
I
E
A
V
A
K
A
K
K
L
D
E
A
L
A
Q
Y
FGNGT---------------------------------------------------------------------------------------------------------------------------
29
HHSearch
68.58
22%
39
- C2 -
-
5GVE
-
?
A:
[52-599]
-----------------------------------------------------------
R
F
K
M
T
S
V
C
G
H
V
M
T
L
---
D
F
L
G
K
Y
N
-------
K
W
-------
D
K
V
D
P
A
E
L
-------------
F
S
Q
A
--
P
----------
T
E
K
K
EAN
P
K
----
L
N
M
V
K
F
L
Q
V
E
G
R
G
C
--
D
Y
I
V
L
W
L
D
C
D
K
E
G
E
N
I
C
F
E
V
L
D
A
V
L
P
VMNKAHGG
E
---
K
T
---
V
F
--
R
A
R
F
S
S
I
T
D
T
D
I
C
N
A
M
A
C
L
G
E
P
D
H
--
N
E
-
A
L
S
V
D
A
R
Q
E
L
D
L
R
I
G
C
A
F
T
R
F
Q
T
K
-----
Y
F
Q
GKYGDLDS-----------
L
I
S
F
G
P
C
Q
T
P
T
L
G
F
C
V
E
R
H
D
K
I
Q
S
F
K
P
E
T
Y
W
V
----
L
----
Q
A
K
V
N
T
DKD
R
S
------
L
L
L
-
D
W
--
D
-----------------------
R
--
V
R
V
F
D
R
E
I
---------
A
Q
M
F
L
N
M
T
-
K
L
E
K
E
A
Q
V
E
A
T
S
R
K
E
K
A
K
Q
R
P
L
A
L
N
T
V
E
M
L
R
V
A
S
S
S
L
G
M
G
P
Q
H
A
M
Q
T
A
E
R
L
Y
T
Q
--------
G
-------
Y
I
S
Y
P
R
T
E
T
T
H
Y
P
E
N
F
-
D
----
L
K
G
S
L
R
Q
Q
--
A
NHP
Y
W
A
D
T
-
V
K
R
L
L
A
--
E
G
I
N
R
P
R
K
G
H
D
--
A
G
D
H
P
P
I
T
P
M
------
K
S
A
---
T
E
---------
A
E
L
G
G
D
A
---
W
R
L
Y
E
Y
I
T
R
H
F
I
A
T
V
S
H
D
C
K
Y
L
Q
S
T
I
S
F
R
I
----
G
P
E
L
F
T
C
S
G
K
T
V
--
L
S
----
P
G
F
--------
T
---
E
-----
V
M
P
W
Q
-----------
S
VPLEE---
S
L
P
T
C
Q
R
G
D
A
F
P
V
G
E
V
K
M
L
E
K
Q
-----------
T
N
P
P
D
Y
-
L
T
E
A
E
L
I
T
L
M
E
-----------------
K
H
G
-----------------
I
G
T
D
A
S
I
P
V
H
I
N
N
I
C
Q
R
N
Y
V
T
V
E
S
G
R
R
-
L
K
P
T
N
L
G
I
V
L
V
H
G
Y
Y
---
K
I
DA
E
---
L
V
L
P
T
I
R
S
A
V
E
K
Q
L
N
L
I
A
Q
G
K
A
D
Y
R
Q
V
L
G
H
T
L
D
V
F
K
R
K
F
H
Y
F
V
D
--------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
67.60
22%
39
- C2 -
-
5GVC
-
?
A:
[54-601]
-----------------------------------------------------------
R
F
K
M
T
S
V
C
G
H
V
M
T
L
---
D
F
L
G
----------
K
W
-------
D
K
V
D
P
A
E
L
-------------
F
S
Q
A
--
P
----------
T
E
K
K
EAN
P
K
----
L
N
M
V
K
F
L
Q
V
E
G
R
G
C
--
D
Y
I
V
L
W
L
D
C
D
K
E
G
E
N
I
C
F
E
V
L
D
A
V
L
P
VMNKAHGG
E
---
K
T
---
V
F
--
R
A
R
F
S
S
I
T
D
T
D
I
C
N
A
M
A
C
L
G
E
P
D
H
--
N
E
-
A
L
S
V
D
A
R
Q
E
L
D
L
R
I
G
C
A
F
T
R
F
Q
T
K
-----
Y
F
Q
GKYGDLDS-
S
---------
L
I
S
F
G
P
C
Q
T
P
T
L
G
F
C
V
E
R
H
D
K
I
Q
S
F
K
P
E
T
Y
W
V
----
L
----
Q
A
K
V
N
T
DKD
R
S
------
L
L
L
-
D
W
--
D
-----------------------
R
--
V
R
V
F
D
R
E
I
---------
A
Q
M
F
L
N
M
T
-
K
L
E
K
E
A
Q
V
E
A
T
S
R
K
E
K
A
K
Q
R
P
L
A
L
N
T
V
E
M
L
R
V
A
S
S
S
L
G
M
G
P
Q
H
A
M
Q
T
A
E
R
L
Y
T
Q
--------
G
-------
Y
I
S
Y
P
R
T
E
T
T
H
Y
P
E
N
F
-
D
L
K
G
S
L
R
Q
Q
A
N
H
P
------
Y
W
A
D
T
-
V
K
R
L
L
A
--
E
G
I
N
R
P
R
K
G
H
D
--
A
G
D
H
P
P
I
T
P
M
------
K
S
A
---
T
E
---------
A
E
L
G
G
D
A
---
W
R
L
Y
E
Y
I
T
R
H
F
I
A
T
V
S
H
D
C
K
Y
L
Q
S
T
I
S
F
R
I
----
G
P
E
L
F
T
C
S
G
K
T
V
--
L
S
----
P
G
F
--------
T
---
E
-----
V
M
P
W
Q
-----------
S
VPLEE---
S
L
P
T
C
Q
R
G
D
A
F
P
V
G
E
V
K
M
L
E
K
Q
-----------
T
N
P
P
D
Y
-
L
T
E
A
E
L
I
T
L
M
E
-----------------
K
H
G
-----------------
I
G
T
D
A
S
I
P
V
H
I
N
N
I
C
Q
R
N
Y
V
T
V
E
S
G
R
R
-
L
K
P
T
N
L
G
I
V
L
V
H
G
Y
Y
---
K
I
DA
E
---
L
V
L
P
T
I
R
S
A
V
E
K
Q
L
N
L
I
A
Q
G
K
A
D
Y
R
Q
V
L
G
H
T
L
D
V
F
K
R
K
F
H
Y
F
V
D
--------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
67.60
24%
51
- C2 -
-
4RUL
1
TOP1_ECOLI
A:
[14-638]
----------------------------------------------
A
K
A
K
T
I
N
K
Y
L
G
-
S
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
---
P
T
--------------------------------
K
D
E
R
G
A
L
V
N
R
M
G
V
D
--
P
WHNW
E
A
H
Y
E
V
L
P
-----
G
K
----
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
--
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
--------
D
---
D
A
R--
Y
S
--
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
--
K
P
G
E
L
N
I
D
R
-
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
-----
K
I
A
---------
R
---------
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
----
V
D
A
S
T
T
T
P
S
G
E
-----------
A
L
A
L
Q
V
--
T
H
Q
--------------------
N
D
K
P
F
R
P
V
N
K
E
Q
---------
T
Q
A
A
V
S
L
L
-
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
G
-------
Y
-------
I
-
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
-
V
--
N
M
V
R
G
Y
I
S
----
D
---
N
F
G
----
K
K
Y
L
P
E
S
P
N
Q
Y
A
S
K
------
Q
E
A
H
E
A
I
R
P
S
------
D
V
N
---
V
M
---
A
-----
E
S
L
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
----
G
D
F
R
L
K
A
R
G
R
I
L
--
R
F
----
D
G
W
TKVMPALR
K
---
G
-----
D
E
D
R
I
-----------
L
--------
P
A
V
N
K
G
D
A
L
T
L
-
V
-
E
L
T
P
A
Q
H
F
-----------
T
K
P
P
A
R
-
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
-----------------
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
-
N
R
R
-
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
---
E
---
N
FRE
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
-
D
P
-
E
-
E
-
G
GMR
P
----
N
Q
M
V
L
T
S
I
D
C
P
T
C
G
R
K
M
G
I
R
T
A
S
T
G
V
F
L
G
C
S
G
-------------------------------------------------------------------------------------------
49
Fugue
66.86
24%
56
- C2 -
-
4CGY
-
TOP3A_HUMAN
A:
[22-640]
FS
R
A
A
M
E
M
A
L
RGVR
K
V
L
C
V
A
EK
N
D
A
A
K
G
I
A
D
L
L
S
N
GR
M
R
R
R
E
G
L
S
K
F
N
K
I
Y
E
F
D
Y
H
L
-
Y
G
Q
N
V
T
M
V
M
T
S
V
S
G
H
---
L
L
A
H
D
F
Q
M
-
Q
F
R
--
K
W
-------
Q
S
C
N
P
L
V
L
F
-
E
A
---------
E
I
E
K
--
Y
----------
C
P
-----
E
N
----
F
V
D
I
K
K
T
L
E
R
E
T
R
Q
-
C
Q
A
L
V
I
W
T
D
C
D
R
E
G
E
N
I
G
F
E
I
I
H
V
C
K
A
--------
V
---
K
P
N
L
Q
V
L
--
R
A
R
F
S
E
I
T
P
H
A
V
R
T
A
C
E
N
L
T
E
P
D
--
Q
R
V
-
S
D
A
V
D
V
R
Q
E
L
D
L
R
I
G
A
A
F
T
R
F
Q
T
L
-----
R
L
Q
---------
R
I
F
PEVLAEQ
L
I
S
Y
G
S
C
Q
F
P
T
L
G
F
V
V
E
R
F
K
A
I
Q
A
F
V
P
E
I
F
H
R
----
I
----
K
V
T
H
D
H
-----------
K
D
G
-
I
V
--
E
F
N
W
-------------------
K
R
--
H
R
L
F
N
H
T
A
---------
C
L
V
L
Y
Q
L
C
V
E
D
-
P
M
A
T
V
V
E
V
R
S
K
P
K
S
K
W
R
P
Q
A
L
D
T
V
E
L
E
K
L
A
S
R
K
L
R
I
N
A
K
E
T
M
R
I
A
E
K
L
Y
T
Q
G
-------
Y
-------
I
-
S
Y
P
R
T
E
T
N
I
F
P
R
D
L
N
L
--
T
V
L
V
E
Q
Q
T
P
D
--
P
---
R
W
G
A
F
-
A
Q
S
I
L
E
R
G
G
P
T
P
R
N
G
N
K
S
D
Q
A
---
H
P
P
I
H
P
T
------
K
------
Y
---
T
-----
N
N
L
Q
G
D
E
---
Q
R
L
Y
E
F
I
V
R
H
F
L
A
C
C
S
Q
D
A
Q
G
Q
E
T
T
V
E
I
D
I
----
A
Q
E
R
F
V
A
H
G
L
M
I
--
L
A
R
N
Y
L
D
V
Y
--------
P
---
Y
-----
D
H
W
S
D
-----------
K
--------
I
L
P
V
Y
E
Q
G
S
H
F
Q
P
S
T
V
E
M
V
D
G
E
-----------
T
S
P
P
K
L
-
L
T
E
A
D
L
I
A
L
M
E
-----------------
K
H
G
-----------------
I
G
T
D
A
T
H
A
E
H
I
E
T
I
K
A
R
M
Y
V
G
L
T
-
P
D
K
R
F
L
P
G
H
L
G
M
G
L
V
E
G
Y
D
---
S
MGY
E
---
M
S
K
P
D
L
R
A
E
L
E
A
D
L
K
L
I
C
D
G
K
K
D
K
F
V
V
L
R
Q
Q
V
Q
K
Y
K
Q
V
F
I
E
A
V
A
------------------------------------------------------------------------
K
A
K
K
L
D
E
A
L
A
Q
-
Y
F
G
---
N
G
T
-----------------------------------------------
24
HHSearch
65.28
24%
33
- C2 -
-
2GAJ
-
TOP1_THEMA
A:
[23-601]
-----------------------------------------------------
I
L
G
N
--
E
Y
E
V
F
A
S
M
G
H
I
I
D
L
---
P
K
S
K
-
F
--------
G
V
-------
D
L
E
-
K
D
F
E
-------------
P
E
F
A
--
V
----------
I
K
-----
G
K
----
E
K
V
V
E
K
L
K
D
L
A
K
K
---
G
E
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
T
--------
L
---
G
R
---
K
N
--
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
P
R
E
I
D
M
--
K
K
-
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
-----
N
F
K
---------
S
---------
N
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
----
I
----
T
V
N
F
D
G
L
T
---------
A
E
I
-
D
V
--
K
-----------------------
E
--
K
K
F
F
D
A
E
T
---------
L
K
E
I
Q
S
I
-----
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
E
T
KD
G
H
I
A
-------
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
-
K
--
E
E
A
R
N
L
I
T
E
V
-------
F
G
E
E
----
Y
V
G
-----------------
A
H
E
A
I
R
P
T
------
N
V
F
MT-
P
E
E
A
-
G
-----
K
Y
L
N
S
D
Q
---
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
----
K
D
G
K
Y
R
F
K
G
T
V
L
K
K
I
F
----
D
G
Y
--------
E
---
K
-----
V
W
K
T
E
-----------
R
N
T
------
G
E
F
P
F
E
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
-----------
T
K
P
K
P
R
-
Y
T
E
G
S
L
V
K
E
M
E
-----------------
R
L
G
-----------------
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
K
K
I
-
R
G
Y
-
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
---
K
K
YS
D
---
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
--------
I
--------
V
V
D
F
P
T
N
Q
K
C
S
-
C
G
K
E
M
R
L
S
F
G
K
Y
G
F
Y
L
K
C
E
---
C
G
K
T
R
S
V
K
-----------
N
D
E
I
A
V
I
--
D
D
G
K
I
F
L
------------------------------------------------------
27
HHSearch
64.69
24%
57
- C2 -
-
1MW9
-
TOP1_ECOLI
X:
[20-580]
-----------------------------------------------------
Y
L
G
S
--
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
---
P
T
--------------ERGALVN
R
M
G
V
D
P
W
H
N
-
W
E
---------
A
H
Y
E
--
V
----------
L
P
-----
G
K
----
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
--
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D-------
D
---
A
R
---
Y
S
--
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
--
D
R
-
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
-----
K
I
A
---------
R
---------
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
----
V
----
D
A
S
T
T
T
PSGEALA----
L
Q
V
-
T
H
--
Q
N
D
--------------------
K
P
--
F
R
P
V
N
K
E
Q
---------
T
Q
A
A
V
S
L
L
-
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
--------
G
-------
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
-
V
--
N
M
V
R
G
Y
I
S
D
N
-------
F
G
K
K
----
Y
L
P
---
E
S
P
N
Q
Y
A
--------
R
E
A
I
R
P
S
------
D
V
N
---
V
M
AES
L
-----
K
D
M
E
A
D
A
---
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
----
G
D
F
R
L
K
A
R
G
R
I
L
--
R
F
----
D
G
W
--------
T
---
K
-----
V
M
P
A
L
------------EDR-----
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
-----------
T
K
P
P
A
R
-
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
-----------------
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
-
N
R
R
-
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
---
E
NFR
E
---
L
M
N
Y
D
F
T
A
Q
M
E
N
N
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
--------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
64.67
23%
60
- C2 -
-
5D5H
2
TOP1_MYCTU
A:
[37-619]
-----------------------------------------------------
Y
L
G
S
--
G
Y
I
V
E
S
S
R
G
H
I
R
D
L
---
P
R
A
A
S
D
V
P
A
K
Y
K
SQ
P
W
-------
A
--
R
L
G
V
N
V
D
A
D
---------
F
E
P
L
Y
I
I
----------
S
P
-----
E
K
----
R
S
T
V
S
E
L
R
G
L
L
K
D
V
--
D
E
L
Y
L
A
T
D
G
D
R
E
G
E
A
I
A
W
H
L
L
E
T
L
K
P
--------
R
---
I
P
---
V
K
--
R
M
V
F
H
E
I
T
E
P
A
I
R
A
A
A
E
H
P
R
D
L
D
I
--
D
L
-
V
D
A
Q
E
T
R
R
I
L
D
R
L
Y
G
Y
E
V
S
P
V
L
W
K
-----
K
V
A
---------
P
---------
K
L
S
A
G
R
V
Q
S
V
A
T
R
I
I
V
A
R
E
R
D
R
M
A
F
R
S
A
A
Y
W
D
----
I
----
L
A
K
L
D
A
SVSDPDAAPP
T
F
S
A
-
R
L
--
T
A
V
AGRRVATGRDFDSLGTLRKG
D
E
--
V
I
V
L
D
E
G
S
---------
A
T
A
L
A
A
G
L
-
D
G
-
T
Q
L
T
V
A
S
A
E
E
K
P
Y
A
R
R
P
Y
P
P
F
M
T
S
T
L
Q
Q
E
A
S
R
K
L
R
F
S
A
E
R
T
M
S
I
A
Q
R
L
Y
E
N
--------
G
-------
Y
I
T
Y
M
R
T
D
S
T
T
L
S
E
S
A
-
I
--
N
A
A
R
T
Q
A
R
Q
L
-------
Y
G
D
----
E
Y
V
A
P
A
P
R
Q
Y
T
R
K
V
K
N
A
--
Q
E
A
H
E
A
I
R
P
A
------
G
E
T
FAT
P
D
---
A
V
R
R
E
L
D
G
P
N
I
D
D
---
F
R
L
Y
E
L
I
W
Q
R
T
V
A
S
Q
M
A
D
A
R
G
M
T
L
S
L
R
I
T
G
M
SGH
Q
E
V
V
F
S
A
T
G
R
T
L
--
T
F
----
P
G
F
--------
L
---
K
-----
A
Y
V
E
T
V
DELV
G
G
E
A
DD
A
E
R
------
R
L
P
H
L
T
P
G
Q
R
L
D
I
V
E
L
T
P
D
G
H
A
-----------
T
N
P
P
A
R
-
Y
T
E
A
S
L
V
K
A
L
E
-----------------
E
L
G
-----------------
I
G
R
P
S
T
Y
S
S
I
I
K
T
I
Q
D
R
G
Y
V
H
K
K
-
G
S
A
-
L
V
P
S
W
V
A
F
A
V
T
G
L
L
E
---
Q
HFG
R
---
L
V
D
Y
D
F
T
A
A
M
E
D
E
L
D
E
I
A
A
G
N
E
R
R
T
N
W
L
N
N
F
Y
F
G
G
D
H
G
V
P
D
-----------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
62.77
26%
72
- C2 -
-
2GAJ
-
TOP1_THEMA
A:
[30-566]
--------------------------------------------------------------
V
F
A
S
M
G
H
I
I
D
L
PKS
K
F
G
V
D
L
E
K
-
D
F
E
-------------------
P
-
E
F
---------
A
V
I
K
--
G
----------
K
E
-----
K
V
----
V
E
K
L
K
---
D
L
A
K
K
---
G
E
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
T
--------
L
---
G
R
---
K
N
--
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
P
R
---
E
I
D
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
-----
N
F
K
---------
S
---------
N
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
----
I
----
T
V
N
F
D
G
-----------
L
T
A
-
E
I
DV
K
E
K
--------------------
K
F
--
F
D
A
E
T
L
K
E
---------
I
Q
S
I
D
E
L
V
--------
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
-------
E
T
KD
G
H
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
-
K
--
E
E
A
R
N
L
I
T
E
V
FG
E
---
E
Y
V
G
---------------
A
----------
H
E
A
I
R
P
T
NVFMT
P
E
E
A
---
G
K
---
Y
-------
L
N
S
D
Q
---
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
KD--
G
K
Y
R
F
---
K
G
T
V
--
L
K
----
K
I
F
--------
D
---
G
YEKVW
K
T
E
R
N
-----------
T
--------
G
E
F
P
F
E
E
G
E
S
V
K
P
-
V
V
V
K
I
E
E
Q
-----------
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
-----------------
R
L
G
-----------------
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
K
K
I
-
R
G
Y
-
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
K
Y
S
---
D
---
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
----
N
D
-
R
-
I
-
V
--------
V
D
F
P
-
T
N
Q
K
C
S
-
C
G
K
E
M
R
---------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
62.60
27%
49
- C2 -
-
1CY8
2
TOP1_ECOLI
A:
[14-506]
----------------------------------------------
A
K
A
K
T
I
N
K
Y
L
G
-
S
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
---
P
----------------------------------DER
G
A
L
V
N
R
M
G
V
D
--
P
WHNW
E
A
H
Y
E
V
L
P
-----
G
K
----
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
--
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
-
W
H
L
R
E
V
I
G
--------
G
---
D
D
---
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
--
K
P
G
E
L
N
I
D
R
-
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
-----
K
I
A
---------
R
---------
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
----
V
D
A
S
T
T
T
P
S
G
E
-----------
A
L
A
L
Q
V
--
T
H
Q
--------------------
N
D
K
P
F
R
P
V
N
K
E
Q
---------
T
Q
A
A
V
S
L
L
-
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
G
-------
Y
-------
I
-
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
-
V
--
N
M
V
R
G
Y
I
S
----
D
---
N
F
G
----
K
K
Y
L
P
E
S
P
N
Q
Y
A
-----------
H
E
A
I
R
P
S
------
D
V
N
---
V
M
---
A
-----
E
S
L
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
----
G
D
F
R
L
K
A
R
G
R
I
L
--
R
F
----
D
G
W
TKVMPALR
K
---
G
-----
D
E
D
R
I
-----------
L
--------
P
A
V
N
K
G
D
A
L
T
L
-
V
-
E
L
T
P
A
Q
H
F
-----------
T
K
P
P
A
R
-
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
-----------------
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
61.67
24%
34
- C- -
-
2GAI
-
TOP1_THEMA
B:
[23-601]
-----------------------------------------------------
I
L
G
N
--
E
Y
E
V
F
A
S
M
G
H
I
I
D
L
---
P
K
S
K
-
F
--------
G
V
-------
D
L
E
-
K
D
F
E
-------------
P
E
F
A
--
V
----------
I
K
-----
G
K
----
E
K
V
V
E
K
L
K
D
L
A
K
K
---
G
E
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
T
--------
L
---
G
R
---
K
N
--
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
P
R
E
I
D
M
--
K
K
-
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
-----
N
F
K
---------
S
---------
N
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
----
I
----
T
V
N
F
D
G
LT---------
A
E
I
-
D
V
--
K
-----------------------
E
--
K
K
F
F
D
A
E
T
---------
L
K
E
I
Q
S
I
-----
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
ETKDGHI
A
-------
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
-
K
--
E
E
A
R
N
L
I
T
E
V
-------
F
G
E
E
----
Y
V
G
-----------------
A
H
E
A
I
R
P
T
------
N
V
F
MT-
P
E
EA-
G
-----
K
Y
L
N
S
D
Q
---
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
----
K
D
G
K
Y
R
F
K
G
T
V
L
KK
I
F
----
D
G
Y
--------
E
---
K
-----
V
W
K
T
E
-----------
R
NT------
G
E
F
P
F
E
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
-----------
T
K
P
K
P
R
-
Y
T
E
G
S
L
V
K
E
M
E
-----------------
R
L
G
-----------------
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
K
K
I
-
R
G
Y
-
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
---
K
KYS
D
---
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
--------
I
--------
V
V
D
F
P
T
N
Q
K
C
S
-
C
G
K
E
M
R
L
S
F
G
K
Y
G
F
Y
L
K
C
E
---
C
G
K
T
R
S
V
K
-----------
N
D
E
I
A
V
I
--
D
D
G
K
I
F
L
------------------------------------------------------
18
PsiBlast_PDB
60.71
27%
40
- C2 -
-
3PWT
-
TOP1_ECOLI
A:
[12-504]
----------------------------------------------
A
K
A
K
T
I
N
K
Y
L
G
-
S
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
---
P
T
---------------------------------DER
G
A
L
V
N
R
M
G
V
D
--
P
WHNW
E
A
H
Y
E
V
L
P
-----
G
K
----
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
--
H
I
Y
L
A
T
N
L
D
R
E
G
E
A
I
A
-
W
H
L
R
E
V
I
G
--------
G
---
D
D
---
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
--
K
P
G
E
L
N
I
D
R
-
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
-----
K
I
A
---------
R
---------
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
----
V
D
A
S
T
T
T
P
S
G
E
-----------
A
L
A
L
Q
V
--
T
H
Q
--------------------
N
D
K
P
F
R
P
V
N
K
E
Q
---------
T
Q
A
A
V
S
L
L
-
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
G
-------
Y
-------
I
-
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
-
V
--
N
M
V
R
G
Y
I
S
----
D
---
N
F
G
----
K
K
Y
L
P
E
S
P
N
Q
Y
A
----------
A
H
E
A
I
R
P
S
------
D
V
N
---
V
M
---
A
-----
E
S
L
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
----
G
D
F
R
L
K
A
R
G
R
I
L
--
R
F
----
D
G
W
TKVMPALR-----------
E
D
R
I
-----------
L
--------
P
A
V
N
K
G
D
A
L
T
L
-
V
-
E
L
T
P
A
Q
H
F
-----------
T
K
P
P
A
R
-
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
-----------------
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------