@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XX46: (2018-01-02 )
MIISTITEAIGSTPLYRFDNQHYSMPKGSAIYAKLEYLNPGGSIKDRLGSYLIKEGFAQGKINEKTTIIEPTAGNTGIGIALAALTYKLRTVFVVPEKFSLEKQQLMKALGAKIIHSPSEQGIIGAISKSKKLAEEISNSYLPLQFENKDNPAAYYHTLGPEIFHEIKENIHSFVAGIGSGGTFAGTSTFLKEKYPDIRIIGVEPEGSVLNGGDPAPHEIEGIGVEFIPPFLSPLSINQIETISDVEGFNYTRQLAREQGLLVGSSSGAAFAAALREIRRLPPGHRVVTIFPDAADRYLSKNIYL
Atome Classification :
(44 SA)
-------------------------------------.........10........--20........30-.........40........50........60..-.-.-.--..-.70........80........90........100.......110.......120.---.-..---...130.......140...-.....150.......160.......170.......180.......190...--....200...-...-.------210----....------.....220.......230.......240.......250.......260.......270.......280-.--....-...290.......300...---------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------------------M
I
I
S
T
I
T
E
A
IGSTP
L
Y
R
FD--NQHYSMPKG
S
A
--
I
Y
A
K
L
E
Y
LNPGG
S
I
K
D
R
L
G
S
Y
L
I
K
EGFAQGKIN-E-
K
-
T
--
T
I
-
I
EPTAGNT
G
I
G
I
A
L
A
A
L
T
Y
K
L
R
T
V
F
V
VPEKFSL
E
K
Q
Q
L
M
K
A
L
G
A
K
IIHSPSEQGI---
I
-
G
A
---
I
S
K
S
K
K
L
A
E
E
I
SNSY-L
P
L
-
Q
FENKDNPA
A
Y
YHTL
G
P
E
I
F
H
E
I
K
E
N
I
H
S
F
V
A
GIGSGGTFAG
T
S
T
F
L
K
EKY--P
D
I
R
I
I
G
VEP-EGS-V------L------NGGD------PAPHEIEGIGVEFIPPFLSPLSINQ
I
E
TISDVEG
F
N
Y
T
R
Q
L
A
R
EQ
G
L
L
VGSSS
G
A
A
F
A
A
A
L
R
E
I
R
R-L-P--PG
H
R
-
V
V
T
IFPD
A
A
D
R
Y
L
SKNIYL---------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
93.13
70%
-55
- C4 -
-
5HBG
-
CYSM_HELPY
A:
[2-306]
-------------------------------------
M
I
I
T
T
M
Q
D
A
I
G
R
T
P
V
F
K
F
T
--
N
K
D
Y
P
I
P
L
N
S
A
--
I
Y
A
K
L
E
H
L
N
P
G
G
S
V
K
D
R
L
G
Q
Y
L
I
G
E
G
F
K
T
G
K
I
T
-
S
-
K
-
T
--
T
I
-
I
E
P
T
A
G
N
T
G
I
A
L
A
L
V
A
I
K
H
H
L
K
T
I
F
V
V
P
E
K
F
S
T
E
K
Q
Q
I
M
R
A
L
G
A
L
V
I
N
T
P
T
S
E
G
I
---
S
-
G
A
---
I
K
K
S
K
E
L
A
E
S
I
P
D
S
Y
-
L
P
L
-
Q
F
E
N
P
D
N
P
A
A
Y
Y
H
T
L
A
P
E
I
V
Q
E
L
G
T
N
L
T
S
F
V
A
G
I
G
S
G
G
T
F
A
G
T
A
R
Y
L
K
E
R
I
--
P
A
I
R
L
I
G
V
E
P
-
E
G
S
-
I
------
L
------
N
G
G
E
------
P
G
P
H
E
I
E
G
I
G
V
E
F
I
P
P
F
F
E
N
L
D
I
D
G
F
E
T
I
S
D
E
E
G
F
S
Y
T
R
K
L
A
K
K
N
G
L
L
V
G
S
S
S
G
A
A
F
V
A
A
L
K
E
A
Q
R
-
L
-
P
--
E
G
S
Q
-
V
L
T
I
F
P
D
V
A
D
R
Y
L
S
K
G
I
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
93.13
70%
-55
- C4 -
-
5HBG
-
CYSM_HELPY
A:
[2-306]
-------------------------------------
M
I
I
T
T
M
Q
D
A
I
G
R
T
P
V
F
K
F
T
--
N
K
D
Y
P
I
P
L
N
S
A
--
I
Y
A
K
L
E
H
L
N
P
G
G
S
V
K
D
R
L
G
Q
Y
L
I
G
E
G
F
K
T
G
K
I
T
-
S
-
K
-
T
--
T
I
-
I
E
P
T
A
G
N
T
G
I
A
L
A
L
V
A
I
K
H
H
L
K
T
I
F
V
V
P
E
K
F
S
T
E
K
Q
Q
I
M
R
A
L
G
A
L
V
I
N
T
P
T
S
E
G
I
---
S
-
G
A
---
I
K
K
S
K
E
L
A
E
S
I
P
D
S
Y
-
L
P
L
-
Q
F
E
N
P
D
N
P
A
A
Y
Y
H
T
L
A
P
E
I
V
Q
E
L
G
T
N
L
T
S
F
V
A
G
I
G
S
G
G
T
F
A
G
T
A
R
Y
L
K
E
R
I
--
P
A
I
R
L
I
G
V
E
P
-
E
G
S
-
I
------
L
------
N
G
G
E
------
P
G
P
H
E
I
E
G
I
G
V
E
F
I
P
P
F
F
E
N
L
D
I
D
G
F
E
T
I
S
D
E
E
G
F
S
Y
T
R
K
L
A
K
K
N
G
L
L
V
G
S
S
S
G
A
A
F
V
A
A
L
K
E
A
Q
R
-
L
-
P
--
E
G
S
Q
-
V
L
T
I
F
P
D
V
A
D
R
Y
L
S
K
G
I
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
92.55
70%
-51
- C4 -
-
5HBG
1
CYSM_HELPY
B:
[2-306]
-------------------------------------
M
I
I
T
T
M
Q
D
A
I
G
R
T
P
V
F
K
F
T
--
N
K
D
Y
P
I
P
L
N
S
A
--
I
Y
A
K
L
E
H
L
N
P
G
G
S
V
K
D
R
L
G
Q
Y
L
I
G
E
G
F
K
T
G
K
I
T
-
S
-
K
-
T
--
T
I
-
I
E
P
T
A
G
N
T
G
I
A
L
A
L
V
A
I
K
H
H
L
K
T
I
F
V
V
P
E
K
F
S
T
E
K
Q
Q
I
M
R
A
L
G
A
L
V
I
N
T
P
T
S
E
G
I
---
S
-
G
A
---
I
K
K
S
K
E
L
A
E
S
I
P
D
S
Y
-
L
P
L
-
Q
F
E
N
P
D
N
P
A
A
Y
Y
H
T
L
A
P
E
I
V
Q
E
L
G
T
N
L
T
S
F
V
A
G
I
G
S
G
G
T
F
A
G
T
A
R
Y
L
K
E
R
I
--
P
A
I
R
L
I
G
V
E
P
-
E
G
S
-
I
------
L
------
N
G
G
E
------
P
G
P
H
E
I
E
G
I
G
V
E
F
I
P
P
F
F
E
N
L
D
I
D
G
F
E
T
I
S
D
E
E
G
F
S
Y
T
R
K
L
A
K
K
N
G
L
L
V
G
S
S
S
G
A
A
F
V
A
A
L
K
E
A
Q
R
-
L
-
P
--
E
G
S
Q
-
V
L
T
I
F
P
D
V
A
D
R
Y
L
S
K
G
I
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
86.76
57%
-62
- C4 -
-
5B1H
5
?
C:
[1-301]
-------------------------------------
M
L
I
Q
H
V
Q
E
L
I
G
H
T
P
L
M
A
L
P
-----
I
E
V
P
N
H
S
H
--
I
Y
A
K
L
E
M
F
N
P
G
G
S
I
K
D
R
L
G
A
Y
L
I
E
D
G
L
Q
R
G
R
V
N
-
A
-
K
-
T
--
T
I
-
I
E
P
T
A
G
N
T
G
I
G
L
A
L
A
T
Q
A
H
H
L
R
T
I
L
V
V
P
E
K
F
S
M
E
K
Q
V
L
M
Q
A
L
G
A
E
I
V
H
T
P
S
E
E
G
I
---
K
-
G
A
---
I
R
K
A
E
A
L
A
A
T
I
S
N
S
Y
-
V
P
M
-
Q
F
K
N
P
A
N
P
A
A
Y
Y
H
T
L
A
P
E
I
L
A
D
M
P
A
P
I
T
A
F
V
A
G
A
G
S
G
G
T
F
A
G
V
A
A
Y
L
Q
A
Q
D
--
S
A
T
K
A
V
V
V
E
P
-
E
G
S
-
I
------
L
------
N
G
G
P
------
A
H
A
H
R
T
E
G
I
G
V
E
F
I
P
P
F
F
D
Q
V
R
I
D
Q
T
L
T
I
A
D
N
D
A
F
A
Q
V
R
H
L
A
R
D
H
G
L
L
I
G
S
S
S
G
A
A
L
A
A
S
L
Q
L
A
T
N
-
L
-
P
--
A
N
S
H
-
I
V
T
I
F
P
D
S
S
E
R
Y
L
S
Q
K
I
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.76
57%
-61
- C4 -
-
5B1H
4
?
A:
[1-301]
-------------------------------------
M
L
I
Q
H
V
Q
E
L
I
G
H
T
P
L
M
A
L
P
-----
I
E
V
P
N
H
S
H
--
I
Y
A
K
L
E
M
F
N
P
G
G
S
I
K
D
R
L
G
A
Y
L
I
E
D
G
L
Q
R
G
R
V
N
-
A
-
K
-
T
--
T
I
-
I
E
P
T
A
G
N
T
G
I
G
L
A
L
A
T
Q
A
H
H
L
R
T
I
L
V
V
P
E
K
F
S
M
E
K
Q
V
L
M
Q
A
L
G
A
E
I
V
H
T
P
S
E
E
G
I
---
K
-
G
A
---
I
R
K
A
E
A
L
A
A
T
I
S
N
S
Y
-
V
P
M
-
Q
F
K
N
P
A
N
P
A
A
Y
Y
H
T
L
A
P
E
I
L
A
D
M
P
A
P
I
T
A
F
V
A
G
A
G
S
G
G
T
F
A
G
V
A
A
Y
L
Q
A
Q
D
--
S
A
T
K
A
V
V
V
E
P
-
E
G
S
-
I
------
L
------
N
G
G
P
------
A
H
A
H
R
T
E
G
I
G
V
E
F
I
P
P
F
F
D
Q
V
R
I
D
Q
T
L
T
I
A
D
N
D
A
F
A
Q
V
R
H
L
A
R
D
H
G
L
L
I
G
S
S
S
G
A
A
L
A
A
S
L
Q
L
A
T
N
-
L
-
P
--
A
N
S
H
-
I
V
T
I
F
P
D
S
S
E
R
Y
L
S
Q
K
I
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
85.66
58%
-60
- C4 -
-
5B1H
4
?
A:
[1-302]
-------------------------------------
M
L
I
Q
H
V
Q
E
L
I
G
H
T
P
L
M
A
L
P
--
I
E
V
P
-
N
--
H
S
H
--
I
Y
A
K
L
E
M
F
N
P
G
G
S
I
K
D
R
L
G
A
Y
L
I
E
D
G
L
Q
R
G
R
V
N
-
A
-
K
-
T
--
T
I
-
I
E
P
T
A
G
N
T
G
I
G
L
A
L
A
T
Q
A
H
H
L
R
T
I
L
V
V
P
E
K
F
S
M
E
K
Q
V
L
M
Q
A
L
G
A
E
I
V
H
T
P
S
E
E
G
I
---
K
-
G
A
---
I
R
K
A
E
A
L
A
A
T
I
S
N
S
Y
-
V
P
M
-
Q
F
K
N
P
A
N
P
A
A
Y
Y
H
T
L
A
P
E
I
L
A
D
M
P
A
P
I
T
A
F
V
A
G
A
G
S
G
G
T
F
A
G
V
A
A
Y
L
Q
A
Q
D
--
S
A
T
K
A
V
V
V
E
P
-
E
G
S
-
I
------
L
------
N
G
G
P
------
A
H
A
H
R
T
E
G
I
G
V
E
F
I
P
P
F
F
D
Q
V
R
I
D
Q
T
L
T
I
A
D
N
D
A
F
A
Q
V
R
H
L
A
R
D
H
G
L
L
I
G
S
S
S
G
A
A
L
A
A
S
L
Q
L
A
T
N
-
L
-
P
--
A
N
S
H
-
I
V
T
I
F
P
D
S
S
E
R
Y
L
S
Q
K
I
Y
T
---------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
84.75
57%
-61
- C4 -
-
5B1H
4
?
B:
[1-301]
-------------------------------------
M
L
I
Q
H
V
Q
E
L
I
G
H
T
P
L
M
A
L
P
-----
I
E
V
P
N
H
S
H
--
I
Y
A
K
L
E
M
F
N
P
G
G
S
I
K
D
R
L
G
A
Y
L
I
E
D
G
L
Q
R
G
R
V
N
-
A
-
K
-
T
--
T
I
-
I
E
P
T
A
G
N
T
G
I
G
L
A
L
A
T
Q
A
H
H
L
R
T
I
L
V
V
P
E
K
F
S
M
E
K
Q
V
L
M
Q
A
L
G
A
E
I
V
H
T
P
S
E
E
G
I
---
K
-
G
A
---
I
R
K
A
E
A
L
A
A
T
I
S
N
S
Y
-
V
P
M
-
Q
F
K
N
P
A
N
P
A
A
Y
Y
H
T
L
A
P
E
I
L
A
D
M
P
A
P
I
T
A
F
V
A
G
A
G
S
G
G
T
F
A
G
V
A
A
Y
L
Q
A
Q
D
--
S
A
T
K
A
V
V
V
E
P
-
E
G
S
-
I
------
L
------
N
G
G
P
------
A
H
A
H
R
T
E
G
I
G
V
E
F
I
P
P
F
F
D
Q
V
R
I
D
Q
T
L
T
I
A
D
N
D
A
F
A
Q
V
R
H
L
A
R
D
H
G
L
L
I
G
S
S
S
G
A
A
L
A
A
S
L
Q
L
A
T
N
-
L
-
P
--
A
N
S
H
-
I
V
T
I
F
P
D
S
S
E
R
Y
L
S
Q
K
I
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.25
57%
-61
- C4 -
-
5B1I
-
?
A:
[1-301]
-------------------------------------
M
L
I
Q
H
V
Q
E
L
I
G
H
T
P
L
M
A
L
P
-----
I
E
V
P
N
H
S
H
--
I
Y
A
K
L
E
M
F
N
P
G
G
S
I
A
D
R
L
G
A
Y
L
I
E
D
G
L
Q
R
G
R
V
N
-
A
-
K
-
T
--
T
I
-
I
E
P
T
A
G
N
T
G
I
G
L
A
L
A
T
Q
A
H
H
L
R
T
I
L
V
V
P
E
K
F
S
M
E
K
Q
V
L
M
Q
A
L
G
A
E
I
V
H
T
P
S
E
E
G
I
---
K
-
G
A
---
I
R
K
A
E
A
L
A
A
T
I
S
N
S
Y
-
V
P
M
-
Q
F
K
N
P
A
N
P
A
A
Y
Y
H
T
L
A
P
E
I
L
A
D
M
P
A
P
I
T
A
F
V
A
G
A
G
S
G
G
T
F
A
G
V
A
A
Y
L
Q
A
Q
D
--
S
A
T
K
A
V
V
V
E
P
-
E
G
S
-
I
------
L
------
N
G
G
P
------
A
H
A
H
R
T
E
G
I
G
V
E
F
I
P
P
F
F
D
Q
V
R
I
D
Q
T
L
T
I
A
D
N
D
A
F
A
Q
V
R
H
L
A
R
D
H
G
L
L
I
G
S
S
S
G
A
A
L
A
A
S
L
Q
L
A
T
N
-
L
-
P
--
A
N
S
H
-
I
V
T
I
F
P
D
S
S
E
R
Y
L
S
Q
K
I
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.83
70%
-
- C4 -
-
4R2V
-
CYSM_HELPY
A:
[2-306]
-------------------------------------
M
I
I
T
T
M
Q
D
A
I
G
R
T
P
V
F
K
F
T
--
N
K
D
Y
P
I
P
L
N
S
A
--
I
Y
A
K
L
E
H
L
N
P
G
G
S
V
K
D
R
L
G
Q
Y
L
I
E
E
G
F
K
T
G
K
I
T
-
S
-
K
-
T
--
T
I
-
I
E
P
T
A
G
N
T
G
I
A
L
A
L
V
A
I
K
H
H
L
K
T
I
F
V
V
P
E
K
F
S
T
E
K
Q
Q
I
M
R
A
L
G
A
L
V
I
N
T
P
T
S
E
G
I
---
S
-
G
A
---
I
K
K
S
K
E
L
A
E
S
I
P
D
S
Y
-
L
P
L
-
Q
F
E
N
P
D
N
P
A
A
Y
Y
H
T
L
A
P
E
I
V
Q
E
L
G
T
N
L
T
S
F
V
A
G
I
G
S
G
G
T
F
A
G
T
A
R
Y
L
K
E
R
I
--
P
A
I
R
L
I
G
V
E
P
-
E
G
S
-
I
------
L
------
N
G
G
E
------
P
G
P
H
E
I
E
G
I
G
V
E
F
I
P
P
F
F
E
N
L
D
I
D
G
F
E
T
I
S
D
E
E
G
F
S
Y
T
R
K
L
A
K
K
N
G
L
L
V
G
S
S
S
G
A
A
F
V
A
A
L
K
E
A
Q
R
-
L
-
P
--
E
G
S
Q
-
V
L
T
I
F
P
D
V
A
D
R
Y
L
S
K
G
I
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
76.43
40%
-52
- C4 -
-
2Q3C
1
CYSK_MYCTU
A:
[6-303]
--------------------------------------
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
----
R
R
V
T
D
G
A
V
A
D
--
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
-
P
-
D
-
T
--
I
I
-
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
D
G
M
---
S
-
G
A
---
I
A
K
A
E
E
L
A
K
T
D
Q
R
Y
F
-
V
P
Q
-
Q
F
E
N
P
A
N
P
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
R
K
--
P
S
A
R
F
V
A
V
E
P
-
A
A
S
P
V
------
L
------
S
G
G
Q
------
K
G
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
-
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
R
-
P
-
E
N-
A
G
K
L
-
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
76.04
40%
-50
- C4 -
-
2Q3B
4
CYSK_MYCTU
A:
[6-303]
--------------------------------------
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
----
R
R
V
T
D
G
A
V
A
D
--
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
-
P
-
D
-
T
--
I
I
-
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
D
G
M
---
S
-
G
A
---
I
A
K
A
E
E
L
A
K
T
D
Q
R
Y
F
-
V
P
Q
-
Q
F
E
N
P
A
N
P
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
R
K
--
P
S
A
R
F
V
A
V
E
P
-
A
A
S
P
V
------
L
------
S
G
G
Q
------
K
G
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
R
-
P
-
E
N-
A
G
K
L
-
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
75.38
41%
-49
- C4 -
-
2Q3B
4
CYSK_MYCTU
A:
[6-303]
--------------------------------------
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
--
R
V
T
D
G
A
--
V
A
D
--
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
-
P
-
D
-
T
--
I
I
-
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
D
G
M
---
S
-
G
A
---
I
A
K
A
E
E
L
A
K
T
D
Q
R
Y
F
-
V
P
Q
-
Q
F
E
N
P
A
N
P
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
R
K
--
P
S
A
R
F
V
A
V
E
P
-
A
A
S
P
V
------
L
------
S
G
G
Q
------
K
G
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
R
P
E
-
N
--
A
G
K
L
-
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
75.19
40%
-49
- C4 -
-
2Q3D
1
CYSK_MYCTU
A:
[6-308]
--------------------------------------
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
----
R
R
V
T
D
G
A
V
A
D
--
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
-
P
-
D
-
T
--
I
I
-
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
D
G
M
---
S
-
G
A
---
I
A
K
A
E
E
L
A
K
T
D
Q
R
Y
F
-
V
P
Q
-
Q
F
E
N
P
A
N
P
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
R
K
--
P
S
A
R
F
V
A
V
E
P
-
A
A
S
P
V
------
L
------
S
G
G
Q
------
K
G
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
R
-
P
-
E
N-
A
G
K
L
-
I
V
V
V
L
P
D
F
G
E
R
Y
L
S
T
P
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
137
HHSearch
74.84
41%
-48
- C4 -
-
2Q3D
1
CYSK_MYCTU
A:
[5-309]
-------------------------------------
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
--
R
V
T
D
G
A
--
V
A
D
--
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
-
P
-
D
-
T
--
I
I
-
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
D
G
M
---
S
-
G
A
---
I
A
K
A
E
E
L
A
K
T
D
Q
R
Y
F
-
V
P
Q
-
Q
F
E
N
P
A
N
P
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
R
K
--
P
S
A
R
F
V
A
V
E
P
-
A
A
S
P
V
------
L
------
S
G
G
Q
------
K
G
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
R
P
E
-
N
--
A
G
K
L
-
I
V
V
V
L
P
D
F
G
E
R
Y
L
S
T
P
L
F
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
74.34
40%
-53
- C4 -
-
3ZEI
4
CYSK_MYCTU
A:
[3-300]
--------------------------------------
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
----
R
R
V
T
D
G
A
V
A
D
--
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
-
P
-
D
-
T
--
I
I
-
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
D
G
M
---
S
-
G
A
---
I
A
K
A
E
E
L
A
K
T
D
Q
R
Y
F
-
V
P
Q
-
Q
F
E
N
P
A
N
P
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
R
K
--
P
S
A
R
F
V
A
V
E
P
-
A
A
S
P
V
------
L
------
S
G
G
Q
------
K
G
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
R
-
P
-
E
N-
A
G
K
L
-
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
73.15
36%
-46
- C4 -
-
2JC3
1
CYSM_SALTY
C:
[1-292]
---------------------------------------
M
N
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
----
Q
R
I
G
P
D
N
G
S
E
--
I
W
V
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
-
P
-
G
-
D
--
V
L
-
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
E
Q
G
M
---
E
-
G
A
---
R
D
L
A
L
A
M
S
E
R
G
E
G
K
L
-
L
D
--
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
R
Q
T
S
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
L
R
E
Q
E
--
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
-
S
------
I
------
P
G
I
R
------
R
W
P
-------
A
E
Y
M
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
N
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
-
V
A
R
-
A
-
T
--
P
G
A
I
-
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
72.76
41%
-86
- C4 -
-
2EGU
-
?
A:
[3-304]
-------------------------------------
R
T
V
N
S
I
T
E
L
I
G
D
T
P
A
V
K
L
N
--
R
I
V
D
E
D
--
S
A
D
--
V
Y
L
K
L
E
F
M
N
P
G
S
S
V
K
D
R
I
A
L
A
M
I
E
A
A
E
K
A
G
K
L
K
-
P
-
G
-
D
--
T
I
-
V
E
P
T
S
G
N
T
G
I
G
L
A
M
V
A
A
A
K
G
Y
K
A
V
L
V
M
P
D
T
M
S
L
E
R
R
N
L
L
R
A
Y
G
A
E
L
V
L
T
P
G
A
Q
G
M
---
R
-
G
A
---
I
A
K
A
E
E
L
V
R
-
E
H
G
Y
F
-
M
P
---------------
T
T
G
K
E
I
V
E
Q
M
G
D
Q
L
D
A
F
V
A
G
V
G
T
G
G
T
I
T
G
A
G
K
V
L
R
E
A
Y
--
P
N
I
K
I
Y
A
V
E
P
-
A
D
-----------------------------------------
D
I
L
D
T
S
I
Y
D
G
V
I
T
V
T
T
E
E
A
F
A
A
A
R
R
A
A
R
E
E
G
I
L
G
G
I
S
S
G
A
A
I
H
A
A
L
K
V
A
K
E
-
L
-
G
--
K
G
K
K
-
V
L
A
I
I
P
S
N
G
E
R
Y
L
S
T
P
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
72.12
36%
-44
- C4 -
-
2JC3
1
CYSM_SALTY
F:
[1-292]
---------------------------------------
M
N
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
----
Q
R
I
G
P
D
N
G
S
E
--
I
W
V
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
-
P
-
G
-
D
--
V
L
-
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
E
Q
G
M
---
E
-
G
A
---
R
D
L
A
L
A
M
S
E
R
G
E
G
K
L
-
L
D
--
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
R
Q
T
S
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
L
R
E
Q
E
--
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
-
S
------
I
------
P
G
I
R
------
R
W
P
-------
A
E
Y
M
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
N
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
-
V
A
R
-
A
-
T
--
P
G
A
I
-
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
72.07
36%
-41
- C4 -
-
2JC3
1
CYSM_SALTY
D:
[1-292]
---------------------------------------
M
N
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
----
Q
R
I
G
P
D
N
G
S
E
--
I
W
V
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
-
P
-
G
-
D
--
V
L
-
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
E
Q
G
M
---
E
-
G
A
---
R
D
L
A
L
A
M
S
E
R
G
E
G
K
L
-
L
D
--
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
R
Q
T
S
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
L
R
E
Q
E
--
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
-
S
------
I
------
P
G
I
R
------
R
W
P
-------
A
E
Y
M
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
N
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
-
V
A
R
-
A
-
T
--
P
G
A
I
-
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
71.76
45%
-46
- C4 -
-
4OFX
-
?
A:
[4-306]
-------------------------------------
M
V
L
D
N
I
L
Q
V
I
G
K
T
P
V
V
R
L
H
--
R
I
G
Q
S
L
P
--
C
E
--
L
Y
G
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
A
A
M
I
E
S
A
E
K
Q
G
K
I
K
-
P
-
G
-
D
--
T
L
-
I
E
P
T
S
G
N
T
G
I
G
I
A
L
A
G
A
V
K
G
Y
R
V
I
I
T
M
P
E
K
M
S
H
E
K
Q
V
V
L
E
A
L
G
A
T
I
Y
R
T
P
---------E
S
H
---
I
S
L
A
K
R
L
N
Q
E
I
P
N
S
Y
-
I
L
D
-
Q
Y
S
N
A
E
N
P
D
I
H
Y
Q
T
T
G
Q
E
I
L
D
D
M
G
E
N
L
S
M
V
V
M
G
V
G
T
G
G
T
I
I
G
V
A
K
K
L
K
E
V
N
--
P
S
I
Q
I
I
G
V
D
P
-
I
G
S
-
I
------
L
------
G
G
G
D
-------------------------
N
N
L
I
D
E
Y
I
K
I
N
D
K
D
S
F
L
M
A
R
R
L
I
R
E
E
G
L
L
V
G
G
S
S
G
S
A
V
W
A
A
C
Q
A
A
Q
R
-
L
-
K
--
E
G
E
R
-
C
L
V
I
L
P
D
A
I
R
N
Y
L
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
68.44
38%
3
- C4 -
-
3VBE
1
?
D:
[29-328]
------------------------------------------
V
S
Q
L
I
G
R
T
P
L
V
Y
L
N
--
K
--
V
T
E
G
C
G
A
Y
--
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
-
P
G
K
-
T
--
T
L
-
I
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
P
A
K
G
M
---
G
-
G
T
---
V
K
K
A
Y
E
L
L
E
N
T
P
N
A
H
-
M
L
Q
-
Q
F
S
N
P
A
N
T
Q
V
H
F
E
T
T
G
P
E
I
W
E
D
T
N
G
Q
V
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
S
K
N
--
P
N
V
K
I
Y
G
V
E
P
S
E
S
N
-
V
------
L
------
N
G
G
K
------
P
G
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
-
L
A
Q
-
L
-
P
EN
K
G
K
L
-
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
68.00
38%
2
- C4 -
-
3VBE
1
?
B:
[29-328]
------------------------------------------
V
S
Q
L
I
G
R
T
P
L
V
Y
L
N
--
K
--
V
T
E
G
C
G
A
Y
--
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
-
P
G
K
-
T
--
T
L
-
I
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
P
A
K
G
M
---
G
-
G
T
---
V
K
K
A
Y
E
L
L
E
N
T
P
N
A
H
-
M
L
Q
-
Q
F
S
N
P
A
N
T
Q
V
H
F
E
T
T
G
P
E
I
W
E
D
T
N
G
Q
V
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
S
K
N
--
P
N
V
K
I
Y
G
V
E
P
S
E
S
N
-
V
------
L
------
N
G
G
K
------
P
G
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
-
L
A
Q
-
L
-
P
EN
K
G
K
L
-
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
67.97
38%
0
- C4 -
-
3VBE
1
?
A:
[29-328]
------------------------------------------
V
S
Q
L
I
G
R
T
P
L
V
Y
L
N
--
K
--
V
T
E
G
C
G
A
Y
--
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
-
P
G
K
-
T
--
T
L
-
I
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
P
A
K
G
M
---
G
-
G
T
---
V
K
K
A
Y
E
L
L
E
N
T
P
N
A
H
-
M
L
Q
-
Q
F
S
N
P
A
N
T
Q
V
H
F
E
T
T
G
P
E
I
W
E
D
T
N
G
Q
V
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
S
K
N
--
P
N
V
K
I
Y
G
V
E
P
S
E
S
N
-
V
------
L
------
N
G
G
K
------
P
G
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
-
L
A
Q
-
L
-
P
EN
K
G
K
L
-
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
66.40
39%
-3
* C4 *
-
2ISQ
1
CYSK1_ARATH
A:
[3-307]
--------------------------------------
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
--
N
V
A
E
G
C
--
V
G
R
--
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
-
P
-
G
E
S
--
V
L
-
I
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
P
A
K
G
M
---
K
-
G
A
---
I
A
K
A
E
E
I
L
A
K
T
P
N
G
Y
-
M
L
Q
-
Q
F
E
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
K
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
E
Q
N
--
A
N
V
K
L
Y
G
V
E
P
-
V
E
S
A
I
------
L
------
S
G
G
K
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
Q
R
-
P
E
N
--
A
G
K
L
-
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
V
L
F
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
65.83
39%
11
- C4 -
-
2EFY
2
?
B:
[6-301]
---------------------------------------------
A
I
G
K
T
P
V
V
R
L
----
A
K
V
V
E
P
D
M
A
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
-
P
-
G
-
S
GQ
V
I
-
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
R
R
M
---
L
-
A
A
---
R
E
E
A
L
R
L
K
E
E
L
-
G
A
F
-
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
R
I
--
P
H
V
K
V
I
A
V
E
P
-
A
R
S
N
V
------
L
------
S
G
G
K
------
M
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
E
-
L
-
G
--
P
G
K
R
-
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
138
HHSearch
65.44
39%
-3
- C4 -
-
1Z7W
1
CYSK1_ARATH
A:
[5-309]
--------------------------------------
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
--
N
V
A
E
G
C
--
V
G
R
--
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
-
P
-
G
E
S
--
V
L
-
I
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
P
A
K
G
M
---
K
-
G
A
---
I
A
K
A
E
E
I
L
A
K
T
P
N
G
Y
-
M
L
Q
-
Q
F
E
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
K
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
E
Q
N
--
A
N
V
K
L
Y
G
V
E
P
-
V
E
S
A
I
------
L
------
S
G
G
K
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
Q
R
-
P
E
N
--
A
G
K
L
-
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
V
L
F
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
65.10
37%
3
- C4 -
-
4L0D
2
CBS_HUMAN
B:
[76-387]
--------------------------------------
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
--
K
I
G
K
K
F
G
L
K
C
E
--
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
-
P
-
G
-
D
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
A
R
F
---
D
-
S
P
ES
H
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
-
I
L
D
-
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
--
P
G
C
R
I
I
G
V
D
P
-
E
G
S
-
I
LAEPEE
L
------
N
Q
T
E
------
Q
T
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
E
-
L
-
Q
--
E
G
Q
R
-
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
65.08
37%
2
- C4 -
-
4L0D
2
CBS_HUMAN
A:
[76-389]
--------------------------------------
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
--
K
I
G
K
K
F
G
L
K
C
E
--
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
-
P
-
G
-
D
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
A
R
F
---
D
-
S
P
ES
H
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
-
I
L
D
-
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
--
P
G
C
R
I
I
G
V
D
P
-
E
G
S
-
I
LAEPEE
L
------
N
Q
T
E
------
Q
T
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
E
-
L
-
Q
--
E
G
Q
R
-
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
64.68
38%
15
- C4 -
-
2ISQ
1
CYSK1_ARATH
A:
[3-306]
--------------------------------------
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
--
N
----
V
A
E
G
C
V
G
R
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
-
P
G
E
-
S
--
V
L
-
I
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
P
A
K
G
M
---
K
-
G
A
---
I
A
K
A
E
E
I
L
A
K
T
P
N
G
Y
-
M
L
Q
-
Q
F
E
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
K
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
E
Q
N
--
A
N
V
K
L
Y
G
V
E
P
V
E
S
A
-
I
------
L
------
S
G
G
K
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
Q
R
-
P
-
E
N-
A
G
K
L
-
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
V
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
142
HHSearch
64.51
38%
-1
- C4 -
-
4AEC
2
CYSKM_ARATH
A:
[114-417]
---------------------------------------
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
N
--
S
I
A
K
G
C
--
V
A
N
--
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
-
P
-
G
K
S
--
V
L
-
V
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
P
A
K
G
M
---
T
-
G
A
---
V
Q
K
A
E
E
I
L
K
N
T
P
D
A
Y
-
M
L
Q
-
Q
F
D
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
D
D
T
K
G
K
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
E
K
N
--
P
K
T
Q
V
I
G
V
E
P
-
T
E
S
D
I
------
L
------
S
G
G
K
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
A
A
A
A
A
I
K
V
A
K
R
-
P
E
N
--
A
G
K
L
-
I
A
V
V
F
P
S
F
G
E
R
Y
L
S
T
P
L
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------
145
Fugue
64.33
39%
29
- C4 -
-
3PC3
2
?
A:
[12-515]
YERPADFIDPGKPSKCKWHLGTAEKSP
H
I
H
R
G
I
AHRQ
Q
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
--
N
I
P
A
S
D
G
I
E
C
E
--
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
-
P
-
G
-
Y
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
T
E
A
A
Y
DSP
E
-
G
L
---
I
Y
V
A
Q
Q
L
Q
R
E
T
P
N
S
I
-
V
L
D
-
Q
Y
R
N
A
G
N
P
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
K
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
Q
V
--
P
S
C
Q
I
V
G
V
D
P
-
Y
G
S
-
I
------
L
ARPAEL
N
K
T
D
------
V
Q
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
R
K
-
L
-
K
--
K
G
Q
R
-
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
F
V
S
D
N
W
M
E
A
R
NF
K
E
P
V
NEHGHWWWSLAIAELELPAPP
V
I
L
K
SDAT
V
G
E
A
I
A
L
M
K
K
H
RVD
Q
L
P
V
V
D
QDDGSVL
G
V
V
G
Q
E
T
L
I
T
Q
I
VSMNRQQSDPAIKALNKRV
I
R
L
N
ESEI
L
G
K
L
A
R
V
L
E
V
DP
S
V
L
I
L
G
K
N
PAG
K
V
E
L
K
A
L
A
T
K
L
D
V
T
T
F
I
A
A
GKQK
74
PsiBlast_CBE
63.83
39%
8
- C4 -
-
2EFY
2
?
A:
[6-301]
---------------------------------------------
A
I
G
K
T
P
V
V
R
L
----
A
K
V
V
E
P
D
M
A
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
-
P
-
G
-
S
G
Q
V
I
-
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
R
R
M
---
L
-
A
A
---
R
E
E
A
L
R
L
K
E
E
L
-
G
A
F
-
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
R
I
--
P
H
V
K
V
I
A
V
E
P
-
A
R
S
N
V
------
L
------
S
G
G
K
------
M
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
E
-
L
-
G
--
P
G
K
R
-
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
63.66
39%
13
- C4 -
-
2ECQ
2
?
A:
[6-301]
---------------------------------------------
A
I
G
K
T
P
V
V
R
L
----
A
K
V
V
E
P
D
M
A
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
-
P
-
G
-
S
G
Q
V
I
-
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
R
R
M
---
L
-
A
A
---
R
E
E
A
L
R
L
K
E
E
L
-
G
A
F
-
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
R
I
--
P
H
V
K
V
I
A
V
E
P
-
A
R
S
N
V
------
L
------
S
G
G
K
------
M
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
E
-
L
-
G
--
P
G
K
R
-
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
63.64
39%
11
- C4 -
-
2ECO
2
?
A:
[6-301]
---------------------------------------------
A
I
G
K
T
P
V
V
R
L
----
A
K
V
V
E
P
D
M
A
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
-
P
-
G
-
S
G
Q
V
I
-
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
R
R
M
---
L
-
A
A
---
R
E
E
A
L
R
L
K
E
E
L
-
G
A
F
-
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
R
I
--
P
H
V
K
V
I
A
V
E
P
-
A
R
S
N
V
------
L
------
S
G
G
K
------
M
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
E
-
L
-
G
--
P
G
K
R
-
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
140
HHSearch
63.45
38%
6
- C4 -
-
4LMB
3
?
A:
[11-316]
---------------------------------------
A
R
D
I
T
Q
L
V
G
R
T
P
L
V
Q
L
N
--
R
I
P
V
A
E
G
V
K
A
R
--
I
V
V
K
L
E
S
M
N
P
A
A
S
V
K
D
R
I
G
V
S
M
V
E
D
A
E
A
A
G
L
I
H
-
P
-
D
K
T
--
I
L
-
V
E
P
T
S
G
N
T
G
I
A
L
A
M
V
A
A
A
K
G
Y
R
L
V
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
Q
L
E
L
T
P
G
S
Q
G
M
---
E
-
G
A
---
I
T
R
A
E
E
I
V
E
N
T
P
N
A
Y
-
S
L
Q
-
Q
F
R
N
P
A
N
P
K
I
H
R
E
T
T
A
E
E
I
W
A
D
T
D
G
L
V
D
I
V
I
G
G
V
G
T
G
G
T
I
T
G
I
A
E
T
I
K
P
R
R
--
P
Q
F
Q
A
I
A
V
E
P
-
S
N
S
P
V
------
L
------
S
G
G
Q
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
A
I
F
R
P
E
L
I
D
E
V
I
I
V
D
D
T
E
A
F
A
Y
A
R
R
L
A
R
Q
E
G
L
L
S
G
I
S
A
G
A
A
L
W
A
A
I
Q
V
G
K
R
P
E
-
N
--
E
D
K
L
-
I
V
M
I
Q
P
S
F
G
E
R
Y
L
S
T
A
L
F
K
---------------------------------------------------------------------------------------------------------------------------------------------------------
143
HHSearch
63.36
38%
1
- C4 -
-
4LMA
3
?
A:
[9-316]
-------------------------------------
R
I
A
H
D
V
T
E
L
V
G
R
T
P
L
V
Q
L
N
--
R
I
P
Q
A
E
G
C
L
G
R
--
I
V
M
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
L
I
N
-
P
-
E
T
T
--
V
L
-
V
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
P
G
S
Q
G
M
---
K
-
G
A
---
I
L
R
A
Q
Q
I
V
D
S
I
P
G
A
Y
-
M
L
Q
-
Q
F
R
N
P
S
N
P
E
I
H
R
L
T
T
A
E
E
I
W
Q
D
T
E
G
Q
V
D
F
I
V
A
G
V
G
T
G
G
T
I
T
G
V
A
E
V
I
K
S
R
K
--
P
S
F
Q
V
V
A
V
E
P
-
F
N
S
P
V
------
I
------
S
G
G
N
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
E
V
L
R
T
D
L
I
D
E
V
I
T
V
S
D
E
E
A
F
Q
F
G
R
R
L
A
K
E
E
G
L
L
S
G
I
S
S
G
A
N
L
C
A
A
I
Q
L
A
Q
R
-
P
E
N
--
E
G
K
L
-
I
V
V
I
Q
P
S
F
G
E
R
Y
L
S
T
L
M
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
63.15
38%
3
- C4 -
-
4LMA
2
?
B:
[10-315]
--------------------------------------
I
A
H
D
V
T
E
L
V
G
R
T
P
L
V
Q
L
N
--
R
I
P
Q
A
E
G
C
L
G
R
--
I
V
M
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
L
I
N
-
P
-
E
-
T
--
T
V
L
V
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
P
G
S
Q
G
M
---
K
-
G
A
---
I
L
R
A
Q
Q
I
V
D
S
I
P
G
A
Y
-
M
L
Q
-
Q
F
R
N
P
S
N
P
E
I
H
R
L
T
T
A
E
E
I
W
Q
D
T
E
G
Q
V
D
F
I
V
A
G
V
G
T
G
G
T
I
T
G
V
A
E
V
I
K
S
R
K
--
P
S
F
Q
V
V
A
V
E
P
-
F
N
S
P
V
------
I
------
S
G
G
N
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
E
V
L
R
T
D
L
I
D
E
V
I
T
V
S
D
E
E
A
F
Q
F
G
R
R
L
A
K
E
E
G
L
L
S
G
I
S
S
G
A
N
L
C
A
A
I
Q
L
A
Q
R
-
P
-
E
N-
E
G
K
L
-
I
V
V
I
Q
P
S
F
G
E
R
Y
L
S
T
L
M
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
62.95
38%
12
- C4 -
-
4AEC
2
CYSKM_ARATH
B:
[113-416]
--------------------------------------
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
N
------
S
I
A
K
G
C
V
A
N
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
-
P
G
K
-
S
--
V
L
-
V
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
P
A
K
G
M
---
T
-
G
A
---
V
Q
K
A
E
E
I
L
K
N
T
P
D
A
Y
-
M
L
Q
-
Q
F
D
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
D
D
T
K
G
K
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
E
K
N
--
P
K
T
Q
V
I
G
V
E
P
T
E
S
D
-
I
------
L
------
S
G
G
K
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
A
A
A
A
A
I
K
V
A
K
R
-
P
-
E
N-
A
G
K
L
-
I
A
V
V
F
P
S
F
G
E
R
Y
L
S
T
P
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
62.86
38%
3
- C4 -
-
4LMA
3
?
A:
[10-315]
--------------------------------------
I
A
H
D
V
T
E
L
V
G
R
T
P
L
V
Q
L
N
--
R
I
P
Q
A
E
G
C
L
G
R
--
I
V
M
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
L
I
N
-
P
-
E
-
T
--
T
V
L
V
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
P
G
S
Q
G
M
---
K
-
G
A
---
I
L
R
A
Q
Q
I
V
D
S
I
P
G
A
Y
-
M
L
Q
-
Q
F
R
N
P
S
N
P
E
I
H
R
L
T
T
A
E
E
I
W
Q
D
T
E
G
Q
V
D
F
I
V
A
G
V
G
T
G
G
T
I
T
G
V
A
E
V
I
K
S
R
K
--
P
S
F
Q
V
V
A
V
E
P
-
F
N
S
P
V
------
I
------
S
G
G
N
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
E
V
L
R
T
D
L
I
D
E
V
I
T
V
S
D
E
E
A
F
Q
F
G
R
R
L
A
K
E
E
G
L
L
S
G
I
S
S
G
A
N
L
C
A
A
I
Q
L
A
Q
R
-
P
-
E
N-
E
G
K
L
-
I
V
V
I
Q
P
S
F
G
E
R
Y
L
S
T
L
M
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
62.81
38%
16
- C4 -
-
1Z7W
1
CYSK1_ARATH
A:
[5-308]
--------------------------------------
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
--
N
----
V
A
E
G
C
V
G
R
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
-
P
G
E
-
S
--
V
L
-
I
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
P
A
K
G
M
---
K
-
G
A
---
I
A
K
A
E
E
I
L
A
K
T
P
N
G
Y
-
M
L
Q
-
Q
F
E
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
K
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
E
Q
N
--
A
N
V
K
L
Y
G
V
E
P
V
E
S
A
-
I
------
L
------
S
G
G
K
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
Q
R
-
P
-
E
N-
A
G
K
L
-
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
V
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
61.59
38%
17
- C4 -
-
4AEC
2
CYSKM_ARATH
A:
[113-416]
--------------------------------------
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
N
------
S
I
A
K
G
C
V
A
N
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
-
P
G
K
-
S
--
V
L
-
V
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
P
A
K
G
M
---
T
-
G
A
---
V
Q
K
A
E
E
I
L
K
N
T
P
D
A
Y
-
M
L
Q
-
Q
F
D
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
D
D
T
K
G
K
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
E
K
N
--
P
K
T
Q
V
I
G
V
E
P
T
E
S
D
-
I
------
L
------
S
G
G
K
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
A
A
A
A
A
I
K
V
A
K
R
-
P
-
E
N-
A
G
K
L
-
I
A
V
V
F
P
S
F
G
E
R
Y
L
S
T
P
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
61.53
37%
6
- C4 -
-
4LMB
3
?
A:
[9-315]
-------------------------------------
L
I
A
R
D
I
T
Q
L
V
G
R
T
P
L
V
Q
L
N
--
R
I
P
V
A
E
G
V
K
A
R
--
I
V
V
K
L
E
S
M
N
P
A
A
S
V
K
D
R
I
G
V
S
M
V
E
D
A
E
A
A
G
L
I
H
P
D
-
K
-
T
--
I
L
-
V
E
P
T
S
G
N
T
G
I
A
L
A
M
V
A
A
A
K
G
Y
R
L
V
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
Q
L
E
L
T
P
G
S
Q
G
M
---
E
-
G
A
---
I
T
R
A
E
E
I
V
E
N
T
P
N
A
Y
-
S
L
Q
-
Q
F
R
N
P
A
N
P
K
I
H
R
E
T
T
A
E
E
I
W
A
D
T
D
G
L
V
D
I
V
I
G
G
V
G
T
G
G
T
I
T
G
I
A
E
T
I
K
P
R
R
--
P
Q
F
Q
A
I
A
V
E
P
-
S
N
S
P
V
------
L
------
S
G
G
Q
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
A
I
F
R
P
E
L
I
D
E
V
I
I
V
D
D
T
E
A
F
A
Y
A
R
R
L
A
R
Q
E
G
L
L
S
G
I
S
A
G
A
A
L
W
A
A
I
Q
V
G
K
R
-
P
-
E
--
N
E
D
K
L
I
V
M
I
Q
P
S
F
G
E
R
Y
L
S
T
A
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
59.26
36%
24
- C4 -
-
3BM5
2
?
B:
[12-318]
--------------------------------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
GV
T
E
H
P
R
I
K
K
G
T
R
--
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
-
P
-
G
-
M
--
E
I
-
I
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
G
K
K
G
M
---
P
-
G
A
---
I
E
E
V
N
K
M
I
K
E
N
P
G
K
Y
F
V
A
N
-
Q
F
G
N
P
D
N
T
A
A
H
H
Y
T
A
N
-
E
I
W
E
D
T
D
G
E
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
E
K
K
--
K
G
I
K
I
I
A
V
E
P
-
E
E
S
A
V
------
L
------
E
G
K
A
------
K
G
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
K
-
P
-
E
N-
E
G
K
T
-
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
147
Fugue
57.53
35%
36
- C4 -
-
1OAS
1
CYSK_SALTY
A:
[1-315]
------------------------------------S
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
--
R
-----
I
G
N
G
R
--
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
-
P
-
G
-
V
--
E
L
-
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
K
G
M
---
K
-
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
P
Q
K
Y
-
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
K
GK
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
V
------
I
------
A
Q
A
L
A
GE
E
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
-
E
-
S
F-
T
N
K
N
-
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
DLF------------------------------------------------------------------------------------------------------------------------------------------------------