@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XX92: (2018-01-03 )
MAEKILVEHLVKKYGDNTVLNDINVSINEGDVVCIIGPSGSGKSTFLRCLNRLEEPSDGEIIIDGAHLMDKSTDINLVRQHIGMVFQHFNLFPHLSILENIILAPMDLKKESREEAEKKAIKLLQTVGLEDKKDMYPEMLSGGQKQRVAIARALAMNPDIMLFDEPTSALDPEMVGDVLNVMKKLAEQGMTMVIVTHEMGFAKEVANRVMFIDDGNFLEDGTPQQIFENPQNERTKDFLNKVLNI
Atome Classification :
(30 SA)
.........10......--..20........30........40........50........60....-------------...---.70--------...--.....80........90........100.......110---.......-----.120...----------..--..130-.......140.......150....-...160.......170.......180......-.190.......200.......210-.......220.......230--.......240...-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
A
E
K
I
L
V
E
H
L
V
K
KYGDN--
T
V
L
N
D
I
N
V
S
INEG
D
V
V
C
I
IGPSGS
G
K
S
T
F
L
R
C
L
N
R
LEEPSDG
E
I
I
I
DG-------------AHL---MDK--------ST
D
--
I
N
L
V
R
Q
H
I
G
M
V
F
Q
H
FNLFP
H
L
S
I
L
E
N
I
ILAPMDL
K
K
-
E
---
S
R
E
E
A
E
K
-----
K
A
I
K
L
L
Q
----------
T
V--GLE
D
K
-
K
D
M
Y
P
E
M
LSGGQ
K
Q
R
V
A
I
A
R
A
LAM-NP
D
I
M
L
FDEPTSAL
D
P
E
M
V
G
D
V
L
N
V
M
K
K
L
A
EQ-G
M
T
M
V
I
V
THEMG
F
A
K
E
V
AN
R
V
M
F
I-DDGNFLEDG
T
P
Q
Q
I
FENPQN--
E
R
T
K
D
F
L
N
K
V
LNI-
1
PsiBlast_PDB
98.60
64%
-131
* C1 *
-
2OLJ
3
?
A:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
--
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
A
K
--------
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
-----
K
A
M
E
L
L
D
----------
K
V
--
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--
E
R
T
K
A
F
L
S
K
V
F
---
26
PsiBlast_CBE
98.20
64%
-126
- C1 -
-
2OLK
1
?
D:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
--
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
A
K
--------
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
-----
K
A
M
E
L
L
D
----------
K
V
--
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--
E
R
T
K
A
F
L
S
K
V
F
---
3
PsiBlast_PDB
97.26
64%
-130
- C1 -
-
2OUK
-
?
A:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
--
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
A
K
--------
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
-----
K
A
M
E
L
L
D
----------
K
V
--
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--
E
R
T
K
A
F
L
S
K
V
F
---
27
PsiBlast_CBE
96.13
64%
-126
- C1 -
-
2OLK
1
?
C:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
--
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
A
K
--------
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
-----
K
A
M
E
L
L
D
----------
K
V
--
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--
E
R
T
K
A
F
L
S
K
V
F
---
5
PsiBlast_PDB
96.06
64%
-123
- C1 -
-
3C4J
2
?
A:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
--
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
A
K
--------
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
-----
K
A
M
E
L
L
D
----------
K
V
--
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--
E
R
T
K
A
F
L
S
K
V
F
---
28
PsiBlast_CBE
95.94
64%
-124
- C1 -
-
2OLK
2
?
B:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
--
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
A
K
--------
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
-----
K
A
M
E
L
L
D
----------
K
V
--
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--
E
R
T
K
A
F
L
S
K
V
F
---
2
PsiBlast_PDB
95.92
64%
-127
- C1 -
-
2OLK
1
?
A:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
--
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
A
K
--------
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
-----
K
A
M
E
L
L
D
----------
K
V
--
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--
E
R
T
K
A
F
L
S
K
V
F
---
21
PsiBlast_CBE
95.50
64%
-126
- C1 -
-
3C4J
2
?
B:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
--
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
A
K
--------
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
-----
K
A
M
E
L
L
D
----------
K
V
--
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--
E
R
T
K
A
F
L
S
K
V
F
---
4
PsiBlast_PDB
95.29
64%
-124
- C1 -
-
2Q0H
3
?
A:
[23-263]
--
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
--
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
A
K
--------
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
-----
K
A
M
E
L
L
D
----------
K
V
--
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--
E
R
T
K
A
F
L
S
K
V
F
---
22
PsiBlast_CBE
95.27
64%
-129
- C1 -
-
2Q0H
3
?
B:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
--
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
A
K
--------
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
-----
K
A
M
E
L
L
D
----------
K
V
--
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--
E
R
T
K
A
F
L
S
K
V
F
---
29
PsiBlast_CBE
95.06
64%
-122
- C1 -
-
2OLJ
2
?
B:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
--
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
A
K
--------
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
-----
K
A
M
E
L
L
D
----------
K
V
--
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--
E
R
T
K
A
F
L
S
K
V
F
---
31
PsiBlast_CBE
93.94
62%
-130
- C1 -
-
4YMV
1
?
A:
[2-240]
----
I
F
V
N
D
V
Y
K
N
F
G
S
L
--
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
---
N
N
G
--------
K
V
N
--
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
-
M
---
N
K
K
E
A
E
E
-----
L
A
V
D
L
L
A
----------
K
V
--
G
L
L
D
K
-
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
--
E
R
T
R
E
F
L
S
K
I
L
---
30
PsiBlast_CBE
93.73
64%
-126
- C1 -
-
3C41
2
?
K:
[6-242]
------
V
H
Q
L
K
K
S
F
G
S
L
--
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
A
K
--------
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
-----
K
A
M
E
L
L
D
----------
K
V
--
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--
E
R
T
K
A
F
L
S
K
V
F
---
32
PsiBlast_CBE
93.65
62%
-135
- C1 -
-
4YMU
1
?
A:
[2-240]
----
I
F
V
N
D
V
Y
K
N
F
G
S
L
--
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
---
N
N
G
--------
K
V
N
--
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
-
M
---
N
K
K
E
A
E
E
-----
L
A
V
D
L
L
A
----------
K
V
--
G
L
L
D
K
-
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
--
E
R
T
R
E
F
L
S
K
I
L
---
6
PsiBlast_PDB
93.38
64%
-117
- C1 -
-
3C41
2
?
J:
[6-242]
------
V
H
Q
L
K
K
S
F
G
S
L
--
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
A
K
--------
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
-----
K
A
M
E
L
L
D
----------
K
V
--
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--
E
R
T
K
A
F
L
S
K
V
F
---
9
PsiBlast_PDB
93.06
62%
-130
- C1 -
-
4YMU
1
?
J:
[2-240]
----
I
F
V
N
D
V
Y
K
N
F
G
S
L
--
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
---
N
N
G
--------
K
V
N
--
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
-
M
---
N
K
K
E
A
E
E
-----
L
A
V
D
L
L
A
----------
K
V
--
G
L
L
D
K
-
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
--
E
R
T
R
E
F
L
S
K
I
L
---
7
PsiBlast_PDB
92.86
62%
-131
- C1 -
-
4YMS
-
?
J:
[2-240]
----
I
F
V
N
D
V
Y
K
N
F
G
S
L
--
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
---
N
N
G
--------
K
V
N
--
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
-
M
---
N
K
K
E
A
E
E
-----
L
A
V
D
L
L
A
----------
K
V
--
G
L
L
D
K
-
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
--
E
R
T
R
E
F
L
S
K
I
L
---
11
PsiBlast_PDB
92.44
62%
-128
- C1 -
-
4YMW
-
?
J:
[2-240]
----
I
F
V
N
D
V
Y
K
N
F
G
S
L
--
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
---
N
N
G
--------
K
V
N
--
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
-
M
---
N
K
K
E
A
E
E
-----
L
A
V
D
L
L
A
----------
K
V
--
G
L
L
D
K
-
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
--
E
R
T
R
E
F
L
S
K
I
L
---
10
PsiBlast_PDB
91.53
62%
-132
- C1 -
-
4YMV
1
?
J:
[2-240]
----
I
F
V
N
D
V
Y
K
N
F
G
S
L
--
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
---
N
N
G
--------
K
V
N
--
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
-
M
---
N
K
K
E
A
E
E
-----
L
A
V
D
L
L
A
----------
K
V
--
G
L
L
D
K
-
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
--
E
R
T
R
E
F
L
S
K
I
L
---
8
PsiBlast_PDB
91.27
62%
-130
- C1 -
-
4YMT
-
?
J:
[2-240]
----
I
F
V
N
D
V
Y
K
N
F
G
S
L
--
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
---
N
N
G
--------
K
V
N
--
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
-
M
---
N
K
K
E
A
E
E
-----
L
A
V
D
L
L
A
----------
K
V
--
G
L
L
D
K
-
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
--
E
R
T
R
E
F
L
S
K
I
L
---
12
PsiBlast_PDB
88.73
56%
-120
- C1 -
-
4U00
1
?
A:
[5-243]
----
I
R
I
R
N
L
H
K
W
F
G
P
L
--
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
---
K
D
D
--------
R
A
---
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
-
W
---
P
R
E
K
A
E
K
-----
K
A
L
E
L
L
E
----------
R
V
--
G
I
L
D
Q
-
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
--
E
R
T
R
S
F
L
Q
R
V
L
H
--
14
PsiBlast_PDB
77.53
50%
-9
- C1 -
-
1B0U
1
HISP_SALTY
A:
[6-257]
---
K
L
H
V
I
D
L
H
K
R
Y
G
G
H
--
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
-------------
Q
N
I
N
L
V
R
D
K
DGQLKVAD
K
N
Q
--
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
G
-
L
---
S
K
H
D
A
R
E
-----
R
A
L
K
Y
L
A
----------
K
V
--
G
I
D
E
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
-
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
-
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
--
P
R
L
Q
Q
F
L
K
G
S
L
---
125
Fugue
60.46
50%
40
- C1 -
-
1B0U
1
HISP_SALTY
A:
[5-261]
--
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
-HE
V
L
K
-
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
QNI
N
L
V
R
D
KDGQL
K
V
A
---
D
K
N
--------
Q
L
R
--
L
L
R
T
-
R
-
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
-G
L
---
S
K
H
D
A
R
E
-----
R
A
L
K
Y
L
A
K
V
GIDERAQG------------
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E-
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
-
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
-
Q
S
P
R
L
Q
Q
F
L
K
G
S
L
K
K
L
E
48
PsiBlast_CBE
56.05
44%
-2
- C1 -
-
3TIF
3
Y796_METJA
B:
[20-221]
--------------------
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
---
N
D
L
--------
D
D
D
EL
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
-
R
GAM
S
G
E
E
R
R
K
-----
R
A
L
E
C
L
K
----------
M
A
--
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
-
K
D
G
---------------------------------
46
PsiBlast_CBE
55.53
44%
1
- C1 -
-
1L2T
3
Y796_METJA
B:
[20-221]
--------------------
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
---
N
D
L
--------
D
D
D
EL
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
-
R
GAM
S
G
E
E
R
R
K
-----
R
A
L
E
C
L
K
----------
M
A
--
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
-
K
D
G
---------------------------------
49
PsiBlast_CBE
55.00
44%
-4
- C1 -
-
3TIF
4
Y796_METJA
A:
[20-221]
--------------------
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
---
N
D
L
--------
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
-
R
G
A
M
S
G
E
E
R
R
K
-----
R
A
L
E
C
L
K
----------
M
A
--
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
-
K
D
G
---------------------------------
47
PsiBlast_CBE
54.54
44%
1
- C1 -
-
1L2T
3
Y796_METJA
A:
[20-221]
--------------------
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
---
N
D
L
--------
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
-
R
G
A
M
S
G
E
E
R
R
K
-----
R
A
L
E
C
L
K
----------
M
A
--
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
-
K
D
G
---------------------------------
117
PsiBlast_CBE
53.52
36%
-60
- C1 -
-
4AYX
1
ABCBA_HUMAN
A:
[359-574]
--------------------
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
--------------
H
D
---
I
R
Q
--------
L
N
P
--
V
W
L
-
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
G
A
D
D
P
S
S
-
V
---
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
----------
N
F
PQ
G
F
N
T
V
-
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
-
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
-
N
--
G
-------------
118
PsiBlast_CBE
51.73
36%
-59
- C1 -
-
4AYT
1
ABCBA_HUMAN
A:
[359-567]
--------------------
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
--------------
H
D
---
I
R
Q
--------
L
N
P
--
V
W
L
-
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
G
A
D
D
P
S
S
-
V
---
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
----------
N
F
PQ
G
F
N
T
V
-
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
-
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-----------------------
120
PsiBlast_CBE
48.64
36%
-59
- C1 -
-
4AYW
1
ABCBA_HUMAN
A:
[390-598]
--------------------
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
--------------
H
D
---
I
R
Q
--------
L
N
P
--
V
W
L
-
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
G
A
D
D
P
S
S
-
V
---
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
----------
N
F
PQ
G
F
N
T
V
-
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
--
G
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
-
A
N
M
V
A
V
L
-
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-----------------------