@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZL8: (2018-01-15 )
MRHIELKNKIVFVTGVAGFIGSNLTKRLFADIEGVKVVGIDNMNDYYDVRLKEARLEELFKFENFVFVKGNLADKAVITAIFEEHHPNIVVNLGAQAGVRYSIINPDAYIEGNMIGFYNILEACRHYPVEHLVYASSSSVYGSNKKIPYSTDDKVDNPVSLYAATKKSNELMTHAYSKLYNIPSTGLRFFTVYGPAGRPDMAYFGFTNKLLKGETIQIFNYGNCKRDFTYIDDIVEGVIRIMQGAPEKQTGEDGLPVPPYAVYNIGNHNPENLLDFVQILLEELIRAGVLPEDYDFEAHKELVPMQPGDVPVTYADTEALERDYGFKPATPLRTGLRKFAEWYKEFYMSETV
Atome Classification :
(20 SA)
.........10........20........30........40........50....-...-.60........70--.........80........90........100.......110.......120.....-.-.130-------........-.-140---------.......---------------150-.........160.......170.......--180.......190..----------.....200------.----....-------....210--.--.--......220----.........230.......240.......------250.....---..260.......--270.......280.......290.......300.--......310.......320.......330........340.......350------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MR
H
I
E
LKN
K
I
V
F
V
TG
V
A
G
F
I
G
S
N
L
T
K
R
L
F
ADIE
G
V
K
V
V
G
IDNMND
Y
Y
D
V
R
L
K
E
A
R
-
L
E
E
-
L
FKFE
N
F
V
F
V
KG---NLA
D
K
A
V
I
T
A
I
F
E
EHHP
N
I
V
V
N
LGAQA
G
V
R
Y
S
I
INPD
A
Y
IEGN
M
I
G
F
Y
N
I
L
E
A
C
R
HY-P-
V
E
---------
H
L
V
YASSS-S-VYG---------SNKKIPY---------------S---TDDKVDNP
V
S
L
Y
A
ATKKS
N
E
L
M
T
H
A
Y
S
K
L--YNIPST
G
L
R
F
F
T
V
YG----------PAGRPD--------
M
----
A
Y
FG-------FTNKLL---K--G--
E
T
I
Q
I
F
N------YGNCKR
D
F
T
Y
I
D
D
I
V
E
G
V
I
R
I
MQGAPEKQ------TGEDGLPV---PP
Y
A
V
Y
NIGNH
N
--
P
E
N
L
L
D
F
V
Q
I
L
L
E
E
L
I
RAGVLPEDYD
F
E
A
H
K
ELV--PMQPGDV
P
V
T
YA
D
T
E
A
L
E
RDYGFKPAT-
P
L
R
T
G
L
R
K
F
A
E
W
Y
K
E
F
Y
MSETV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
93.15
55%
-65
- C1 -
-
5U4Q
1
?
A:
[3-336]
-------
A
M
K
F
L
V
T
G
A
A
G
F
I
G
F
H
I
A
Q
R
L
L
N
--
E
G
H
N
V
V
G
I
D
N
M
N
D
Y
Y
D
V
S
L
K
Q
A
R
-
L
D
R
-
L
-
A
Y
P
A
F
H
F
Q
Q
L
---
D
L
A
D
R
E
G
M
A
K
L
F
A
T
E
Q
F
D
R
V
I
H
L
A
A
Q
A
-------
N
P
Y
A
Y
A
D
A
N
L
M
G
Y
L
N
I
L
E
G
C
R
H
T
-
K
-
V
K
---------
H
L
V
Y
A
S
S
S
-
S
-
V
Y
G
---------
L
N
R
K
M
P
F
---------------
S
---
T
E
D
S
V
D
H
P
V
S
L
Y
A
A
T
K
K
A
N
E
L
M
A
H
T
Y
S
H
L
--
Y
G
I
P
T
T
G
L
R
F
F
T
V
Y
G
----------
P
W
G
R
P
D
--------
M
----
A
L
F
K
-------
F
T
K
A
M
L
---
E
--
G
--
K
S
I
D
V
Y
N
------
Y
G
K
M
K
R
D
F
T
Y
I
D
D
I
V
E
A
V
V
R
V
L
D
V
I
P
Q
A
N
ADWTVE
S
G
S
P
A
T
S
S
---
A
P
Y
R
V
Y
N
I
G
N
S
S
--
P
V
E
L
M
D
Y
I
T
A
L
E
E
A
L
G
M
E
A
Q
----------
K
N
M
M
--
P
I
-------
T
S
A
D
T
Q
P
L
Y
D
L
V
G
F
K
P
Q
T
-
S
V
K
D
G
V
K
N
F
V
D
W
Y
K
D
Y
Y
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.07
53%
-63
- C1 -
-
5U4Q
1
?
A:
[7-336]
-----------
L
V
T
G
A
A
G
F
I
G
F
H
I
A
Q
R
L
L
N
--
E
G
H
N
V
V
G
I
D
N
M
N
D
Y
Y
D
V
S
L
K
Q
A
R
-
L
D
R
-
L
-
A
Y
P
A
F
H
F
Q
Q
L
---
D
L
A
D
R
E
G
M
A
K
L
F
A
T
E
Q
F
D
R
V
I
H
L
A
A
Q
A
-------
N
P
Y
A
Y
A
D
A
N
L
M
G
Y
L
N
I
L
E
G
C
R
H
T
-
K
-
V
K
---------
H
L
V
Y
A
S
S
S
-
S
-
V
Y
G
---------
L
N
R
K
M
P
F
---------------
S
---
T
E
D
S
V
D
H
P
V
S
L
Y
A
A
T
K
K
A
N
E
L
M
A
H
T
Y
S
H
L
--
Y
G
I
P
T
T
G
L
R
F
F
T
V
Y
G
----------
P
W
G
R
P
D
--------
M
----
A
L
F
K
-------
F
T
K
A
M
L
---
E
--
G
--
K
S
I
D
V
Y
N
------
Y
G
K
M
K
R
D
F
T
Y
I
D
D
I
V
E
A
V
V
R
V
L
D
V
I
P
Q
A
N
ADW---
T
V
E
S
G
S
P
A
TSS
A
P
Y
R
V
Y
N
I
G
N
S
S
--
P
V
E
L
M
D
Y
I
T
A
L
E
E
A
L
----------
G
M
E
A
Q
K
N
M
M
--
P
I
-------
T
S
A
D
T
Q
P
L
Y
D
L
V
G
F
K
P
Q
T
-
S
V
K
D
G
V
K
N
F
V
D
W
Y
K
D
Y
Y
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
86.72
55%
-65
- C1 -
-
5U4Q
1
?
B:
[3-336]
-------
A
M
K
F
L
V
T
G
A
A
G
F
I
G
F
H
I
A
Q
R
L
L
N
--
E
G
H
N
V
V
G
I
D
N
M
N
D
Y
Y
D
V
S
L
K
Q
A
R
-
L
D
R
-
L
-
A
Y
P
A
F
H
F
Q
Q
L
---
D
L
A
D
R
E
G
M
A
K
L
F
A
T
E
Q
F
D
R
V
I
H
L
A
A
Q
A
G
V
R
--
L
E
N
P
Y
A
Y
A
D
A
N
L
M
G
Y
L
N
I
L
E
G
C
R
H
T
-
K
-
V
K
---------
H
L
V
Y
A
S
S
S
-
S
-
V
Y
G
---------
L
N
R
K
M
P
F
---------------
S
---
T
E
D
S
V
D
H
P
V
S
L
Y
A
A
T
K
K
A
N
E
L
M
A
H
T
Y
S
H
L
--
Y
G
I
P
T
T
G
L
R
F
F
T
V
Y
G
----------
P
W
G
R
P
D
--------
M
----
A
L
F
K
-------
F
T
K
A
M
L
---
E
--
G
--------------------
R
D
F
T
Y
I
D
D
I
V
E
A
V
V
R
V
L
D
V
I
P
Q
A
N
ADWTVE
S
G
S
P
A
T
S
S
---
A
P
Y
R
V
Y
N
I
G
N
S
S
--
P
V
E
L
M
D
Y
I
T
A
L
E
E
A
L
G
M
----------------------------
T
S
A
D
T
Q
P
L
Y
D
L
V
G
F
K
P
Q
T
-
S
V
K
D
G
V
K
N
F
V
D
W
Y
K
D
Y
Y
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
65.96
25%
-96
- C1 -
-
4EGB
17
?
A:
[27-336]
----------
I
L
V
T
G
G
A
G
F
I
G
S
N
F
V
H
Y
M
L
Q
S
Y
E
T
Y
K
I
I
N
F
D
A
L
T
--
Y
S
G
N
L
N
N
V
K
---
S
-
I
Q
D
H
P
N
Y
Y
F
V
K
G
---
E
I
Q
N
G
E
L
L
E
H
V
I
K
E
R
D
V
Q
V
I
V
N
F
A
A
E
S
---------
I
P
F
Y
D
T
N
V
I
G
T
V
T
L
L
E
L
V
K
K
Y
-
P
-
H
I
---------
K
L
V
Q
V
S
T
D
-
E
-
V
Y
G
---------
S
L
G
K
T
G
R
---------------
F
---
T
E
E
T
P
L
A
P
N
S
P
Y
S
S
S
K
A
S
A
D
M
I
A
L
A
Y
Y
K
T
--
Y
Q
L
P
V
I
V
T
R
C
S
N
N
Y
G
----------
P
Y
Q
Y
P
E
--------
K
----
L
I
P
L
-------
M
V
T
N
A
L
---
E
--
G
--
K
K
L
P
L
Y
G
------
D
G
L
N
V
R
D
W
L
H
V
T
D
H
C
S
A
I
D
V
V
L
H
K
G
---
R
------
V
G
E
------------
V
Y
N
I
G
G
N
N
--
E
K
T
N
V
E
V
V
E
Q
I
I
T
L
L
---
G
K
T
K
K
D
I
E
Y
------
V
--
T
D
--
G
H
D
R
R
Y
A
I
N
A
E
K
M
K
N
E
F
D
W
E
P
K
Y
-
T
F
E
Q
G
L
Q
E
T
V
Q
W
Y
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
61.74
27%
-18
- C1 -
-
1KEW
5
RMLB_SALTY
A:
[3-334]
----------
I
L
I
T
G
G
A
G
F
I
G
S
A
V
V
R
H
I
I
K
N
T
Q
D
T
-
V
V
N
I
D
K
L
T
--
Y
A
G
N
L
E
S
---
L
S
D
-
I
S
E
S
N
R
Y
N
F
E
H
A
---
D
I
C
D
S
A
E
I
T
R
I
F
E
Q
Y
Q
P
D
A
V
M
H
L
A
A
E
S
H
V
D
R
S
I
T
G
P
A
A
F
I
E
T
N
I
V
G
T
Y
A
L
L
E
V
A
R
K
Y
-
W
-
S
A
LG
E
D
K
K
N
N
F
R
F
H
H
I
S
T
D
-
E
-
V
Y
G
DLPHPDEVE
N
S
V
T
L
P
L
---------------
F
---
T
E
T
T
A
Y
A
P
S
S
P
Y
S
A
S
K
A
S
S
D
H
L
V
R
A
W
R
R
T
--
Y
G
L
P
T
I
V
T
N
C
S
N
N
Y
G
----------
P
Y
H
F
P
E
--------
K
----
L
I
P
L
-------
V
I
L
N
A
L
---
E
--
G
--
K
P
L
P
I
Y
G
------
K
G
D
Q
I
R
D
W
L
Y
V
E
D
H
A
R
A
L
H
M
V
V
T
---
E
G
K
------
A
G
E
------------
T
Y
N
I
G
G
H
N
--
E
K
K
N
L
D
V
V
F
T
I
C
D
L
L
D
E
--
I
V
P
K
A
T
S
Y
R
E
Q
I
T
Y
V
--
A
D
R
P
G
H
D
R
R
Y
A
I
D
A
G
K
I
S
R
E
L
G
W
K
P
L
E
-
T
F
E
S
G
I
R
K
T
V
E
W
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
61.38
31%
-16
- C1 -
-
1SB8
2
?
A:
[23-351]
---
L
P
A
Q
P
K
V
W
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
T
L
L
K
--
L
D
Q
K
V
V
G
L
D
N
F
A
T
G
H
Q
R
N
L
D
E
V
R
-
S
L
V
S
E
K
Q
W
S
N
F
K
F
I
Q
G
---
D
I
R
N
L
D
D
C
N
N
A
C
A
--
G
V
D
Y
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
N
D
P
I
T
S
N
A
T
N
I
D
G
F
L
N
M
L
I
A
A
R
D
A
-
K
-
V
Q
---------
S
F
T
Y
A
A
S
S
-
S
-
T
Y
G
---------
D
H
P
G
L
P
K
---------------
V
----
E
D
T
I
G
K
P
L
S
P
Y
A
V
T
K
Y
V
N
E
L
Y
A
D
V
F
S
R
C
--
Y
G
F
S
T
I
G
L
R
Y
F
N
V
F
G
----------
R
R
Q
D
P
N
--------
G
AYAA
V
I
P
K
-------
W
T
S
S
M
I
---
Q
--
G
--
D
D
V
Y
I
N
G
------
D
G
E
T
S
R
D
F
C
Y
I
E
N
T
V
Q
A
N
L
L
A
A
T
A
G
L
----------------
D
---
A
R
N
Q
V
Y
N
I
A
V
G
G
--
R
T
S
L
N
Q
L
F
F
A
L
R
D
G
L
A
E
N
G
V
---
S
Y
H
R
E
-
P
-
V
Y
R
--
D
F
R
E
G
D
V
R
H
S
L
A
D
I
S
K
A
A
K
L
L
G
Y
A
P
K
Y
-
D
V
S
A
G
V
A
L
A
M
P
W
Y
I
M
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
61.37
27%
-17
- C1 -
-
1KEU
2
RMLB_SALTY
A:
[3-334]
----------
I
L
I
T
G
G
A
G
F
I
G
S
A
V
V
R
H
I
I
K
N
T
Q
D
T
-
V
V
N
I
D
K
L
T
--
Y
A
G
N
L
E
S
---
L
S
D
-
I
S
E
S
N
R
Y
N
F
E
H
A
---
D
I
C
D
S
A
E
I
T
R
I
F
E
Q
Y
Q
P
D
A
V
M
H
L
A
A
E
S
H
V
D
R
S
I
T
G
P
A
A
F
I
E
T
N
I
V
G
T
Y
A
L
L
E
V
A
R
K
Y
-
W
-
S
A
LG
E
D
K
K
N
N
F
R
F
H
H
I
S
T
D
-
E
-
V
Y
G
DLPHPDEVE
N
S
V
T
L
P
L
---------------
F
---
T
E
T
T
A
Y
A
P
S
S
P
Y
S
A
S
K
A
S
S
D
H
L
V
R
A
W
R
R
T
--
Y
G
L
P
T
I
V
T
N
C
S
N
N
Y
G
----------
P
Y
H
F
P
E
--------
K
----
L
I
P
L
-------
V
I
L
N
A
L
---
E
--
G
--
K
P
L
P
I
Y
G
------
K
G
D
Q
I
R
D
W
L
Y
V
E
D
H
A
R
A
L
H
M
V
V
T
---
E
G
K
------
A
G
E
------------
T
Y
N
I
G
G
H
N
--
E
K
K
N
L
D
V
V
F
T
I
C
D
L
L
D
E
--
I
V
P
K
A
T
S
Y
R
E
Q
I
T
Y
V
--
A
D
R
P
G
H
D
R
R
Y
A
I
D
A
G
K
I
S
R
E
L
G
W
K
P
L
E
-
T
F
E
S
G
I
R
K
T
V
E
W
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
58.76
22%
-46
- C1 -
-
1ORR
2
RFBE_SALTI
B:
[2-339]
--------
A
K
L
L
I
T
G
G
C
G
F
L
G
S
N
L
A
S
F
A
L
S
--
Q
G
I
D
L
I
V
F
D
N
L
S
R
K
G
A
T
---
D
N
L
--
H
W
-
L
S
S
L
G
N
F
E
F
V
H
G
---
D
I
R
N
K
N
D
V
T
R
L
I
T
K
Y
M
P
D
S
C
F
H
L
A
G
Q
V
A
M
T
T
S
I
D
N
P
C
M
D
F
E
I
N
V
G
G
T
L
N
L
L
E
A
V
R
Q
Y
-
N
S
N
C
---------
N
I
I
Y
S
S
T
N
-
K
-
V
Y
G
---------
D
L
E
Q
Y
K
Y
N
E
T
ET
R
Y
T
C
VDKPNG
Y
---
D
E
S
T
Q
L
D
F
H
S
P
Y
G
C
S
K
G
A
A
D
Q
Y
M
L
D
Y
A
R
I
--
F
G
L
N
T
V
V
F
R
H
S
S
M
Y
G
----------
G
R
Q
F
A
T
YDQ-----
G
----
W
V
G
W
-------
F
C
Q
K
A
V
E
I
K
N
GI
N
--
K
P
F
T
I
S
G
------
N
G
K
Q
V
R
D
V
L
H
A
E
D
M
I
S
L
Y
F
T
A
L
A
N
V
S
----------------
K
---
I
R
G
N
A
F
N
I
G
G
T
I
VN
S
L
S
L
L
E
L
F
K
L
L
E
D
Y
C
N
I
D
M
----
R
F
------
T
N
L
--
P
V
R
E
S
D
Q
R
V
F
V
A
D
I
K
K
I
T
N
A
I
D
W
S
P
K
V
-
S
A
K
D
G
V
Q
K
M
Y
D
W
T
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
58.47
29%
-50
* C1 *
-
4ZRM
2
?
B:
[3-310]
-------
H
M
N
I
L
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
I
E
--
N
G
Y
G
V
I
V
V
D
N
L
S
S
G
K
---
V
E
N
-------
L
--
N
R
N
A
L
F
Y
E
Q
---
S
I
E
D
E
E
M
M
E
R
I
F
S
L
H
R
P
E
Y
V
F
H
L
A
A
Q
A
S
V
A
I
S
V
R
E
P
A
R
D
A
K
T
N
I
I
G
S
L
V
L
L
E
K
S
I
K
Y
-
G
-
V
K
---------
K
F
I
F
S
S
T
G
-
G
A
I
Y
G
---------
E
N
V
K
V
F
P
---------------
T
---
P
E
T
E
I
P
H
P
I
S
P
Y
G
I
A
K
Y
S
T
E
M
Y
L
E
F
F
A
R
E
--
Y
G
L
K
Y
T
V
L
R
Y
A
N
V
Y
G
----------
P
R
Q
D
P
Y
GEA-----
G
----
V
V
A
I
-------
F
T
E
R
M
L
---
R
--
G
--
E
E
V
H
I
F
G
------
D
G
E
Y
V
R
D
Y
V
Y
V
D
D
V
V
R
A
N
L
L
A
M
E
K
G
----------------------
D
N
E
V
F
N
I
G
T
G
R
--
G
T
T
V
N
Q
L
F
K
L
L
K
E
I
T
G
Y
D
K
E
--
P
--------
V
Y
K
--
P
P
R
K
G
D
V
R
K
S
I
L
D
Y
T
K
A
K
E
K
L
G
W
E
P
K
V
-
S
L
E
E
G
L
K
L
T
V
E
Y
F
R
K
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
58.33
25%
-65
- C1 -
-
2C20
1
?
C:
[2-327]
--------
N
S
I
L
I
C
G
G
A
G
Y
I
G
S
H
A
V
K
K
L
V
D
--
E
G
L
S
V
V
V
V
D
N
L
Q
T
G
H
E
----
D
A
------
I
--
T
E
G
A
K
F
Y
N
G
---
D
L
R
D
K
A
F
L
R
D
V
F
T
Q
E
N
I
E
A
V
M
H
F
A
A
D
S
L
V
G
V
S
M
E
K
P
L
Q
Y
Y
N
N
N
V
Y
G
A
L
C
L
L
E
V
M
D
E
F
-
K
-
V
D
---------
K
F
I
F
S
S
T
A
-
A
-
T
Y
G
---------
E
V
D
V
D
L
----------------
I
---
T
E
E
T
M
T
N
P
T
N
T
Y
G
E
T
K
L
A
I
E
K
M
L
H
W
Y
S
Q
A
--
S
N
L
R
Y
K
I
F
R
Y
F
N
V
A
G
----------
A
T
P
N
G
I
IGEDHRPE
T
H---
L
I
P
L
-------
V
L
Q
V
A
L
G--
Q
--
R
--
E
K
I
M
M
F
G
DDYNTP
D
G
T
C
I
R
D
Y
I
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
Q
N
---------------
G
---
G
E
S
D
F
Y
N
L
G
N
G
N
--
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
H
E
--
I
P
A
E
--------
V
A
--
P
R
R
A
G
D
P
A
R
L
V
A
S
S
Q
K
A
K
E
K
L
G
W
D
P
R
Y
V
N
V
K
T
I
I
E
H
A
W
N
W
H
Q
K
Q
P
N
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
58.31
29%
-10
- C1 -
-
3RUF
2
GNE_PLESH
S:
[21-350]
---
L
I
F
S
P
K
T
W
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
K
L
L
K
--
L
N
Q
V
V
I
G
L
D
N
F
S
T
G
H
Q
Y
N
L
D
E
V
K
-
T
L
V
S
T
E
Q
W
S
R
F
C
F
I
E
G
---
D
I
R
D
L
T
T
C
E
Q
V
M
K
--
G
V
D
H
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
V
D
P
I
T
T
N
A
T
N
I
T
G
F
L
N
I
L
H
A
A
K
N
A
-
Q
-
V
Q
---------
S
F
T
Y
A
A
S
S
-
S
-
T
Y
G
---------
D
H
P
A
L
P
K
---------------
V
---
E
-
E
N
I
G
N
P
L
S
P
Y
A
V
T
K
Y
V
N
E
I
Y
A
Q
V
Y
A
R
T
--
Y
G
F
K
T
I
G
L
R
Y
F
N
V
F
G
----------
R
R
Q
D
P
N
--------
G
AYAA
V
I
P
K
-------
W
T
A
A
M
L
---
K
--
G
--
D
D
V
Y
I
N
G
------
D
G
E
T
S
R
D
F
C
Y
I
D
N
V
I
Q
M
N
I
L
S
A
L
A
K
D
----------------
S
---
A
K
D
N
I
Y
N
V
A
V
G
D
--
R
T
T
L
N
E
L
S
G
Y
I
Y
D
E
L
N
L
I
H
H
I
----------
K
Y
R
--
E
F
R
S
G
D
V
R
H
S
Q
A
D
V
T
K
A
I
D
L
L
K
Y
R
P
N
I
-
K
I
R
E
G
L
R
L
S
M
P
W
Y
V
R
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
57.92
29%
-45
- C1 -
-
4ZRN
2
?
A:
[4-310]
--------
M
N
I
L
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
I
E
--
N
G
Y
G
V
I
V
V
D
N
L
S
S
G
K
---
V
E
N
-------
L
--
N
R
N
A
L
F
Y
E
Q
---
S
I
E
D
E
E
M
M
E
R
I
F
S
L
H
R
P
E
Y
V
F
H
L
A
A
Q
A
S
V
A
I
S
V
R
E
P
A
R
D
A
K
T
N
I
I
G
S
L
V
L
L
E
K
S
I
K
Y
-
G
-
V
K
---------
K
F
I
F
S
S
T
G
-
G
A
I
Y
G
---------
E
N
V
K
V
F
P
---------------
T
---
P
E
T
E
I
P
H
P
I
S
P
Y
G
I
A
K
Y
S
T
E
M
Y
L
E
F
F
A
R
E
--
Y
G
L
K
Y
T
V
L
R
Y
A
N
V
Y
G
----------
P
R
Q
D
P
Y
GEA-----
G
----
V
V
A
I
-------
F
T
E
R
M
L
---
R
--
G
--
E
E
V
H
I
F
G
------
D
G
E
Y
V
R
D
Y
V
Y
V
D
D
V
V
R
A
N
L
L
A
M
E
K
G
----------------------
D
N
E
V
F
N
I
G
T
G
R
--
G
T
T
V
N
Q
L
F
K
L
L
K
E
I
T
G
Y
D
K
E
--
P
--------
V
Y
K
--
P
P
R
K
G
D
V
R
K
S
I
L
D
Y
T
K
A
K
E
K
L
G
W
E
P
K
V
-
S
L
E
E
G
L
K
L
T
V
E
Y
F
R
K
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
57.04
27%
-12
- C1 -
-
1G1A
1
RMLB_SALTY
A:
[3-334]
----------
I
L
I
T
G
G
A
G
F
I
G
S
A
V
V
R
H
I
I
K
N
T
Q
D
T
-
V
V
N
I
D
K
L
T
--
Y
A
G
N
L
E
S
---
L
S
D
-
I
S
E
S
N
R
Y
N
F
E
H
A
---
D
I
C
D
S
A
E
I
T
R
I
F
E
Q
Y
Q
P
D
A
V
M
H
L
A
A
E
S
H
V
D
R
S
I
T
G
P
A
A
F
I
E
T
N
I
V
G
T
Y
A
L
L
E
V
A
R
K
Y
-
W
-
S
A
LG
E
D
K
K
N
N
F
R
F
H
H
I
S
T
D
-
E
-
V
Y
G
DLPHPDEVE
N
S
V
T
L
P
L
---------------
F
---
T
E
T
T
A
Y
A
P
S
S
P
Y
S
A
S
K
A
S
S
D
H
L
V
R
A
W
R
R
T
--
Y
G
L
P
T
I
V
T
N
C
S
N
N
Y
G
----------
P
Y
H
F
P
E
--------
K
----
L
I
P
L
-------
V
I
L
N
A
L
---
E
--
G
--
K
P
L
P
I
Y
G
------
K
G
D
Q
I
R
D
W
L
Y
V
E
D
H
A
R
A
L
H
M
V
V
T
---
E
G
K
------
A
G
E
------------
T
Y
N
I
G
G
H
N
--
E
K
K
N
L
D
V
V
F
T
I
C
D
L
L
D
E
--
I
V
P
K
A
T
S
Y
R
E
Q
I
T
Y
V
--
A
D
R
P
G
H
D
R
R
Y
A
I
D
A
G
K
I
S
R
E
L
G
W
K
P
L
E
-
T
F
E
S
G
I
R
K
T
V
E
W
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
56.67
30%
-15
- C1 -
-
1SB9
2
?
A:
[21-350]
-
K
E
L
P
A
Q
P
K
V
W
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
T
L
L
K
L
D
Q
--
K
V
V
G
L
D
N
F
A
T
G
H
Q
R
N
L
D
E
V
R
S
L
V
S
-
E
K
Q
W
S
N
F
K
F
I
Q
G
DIR
N
L
D
D
C
N
N
A
C
A
G
V
D
-----
Y
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
N
D
P
I
T
S
N
A
T
N
I
D
G
F
L
N
M
L
I
A
A
R
D
A
-
K
-
V
Q
---------
S
F
T
Y
A
A
S
S
-
S
-
T
Y
G
---------
D
H
P
G
L
P
----------------
K
---
V
E
D
T
I
G
K
P
L
S
P
Y
A
V
T
K
Y
V
N
E
L
Y
A
D
V
F
S
R
C
--
Y
G
F
S
T
I
G
L
R
Y
F
N
V
F
G
----------
R
R
Q
D
P
N
--------
G
----
A
Y
A
A
V
I
P
K
---
W
T
S
S
M
I
---
Q
--
G
--
D
D
V
Y
I
N
G
------
D
G
E
T
S
R
D
F
C
Y
I
E
N
T
V
Q
A
N
L
L
A
A
T
A
G
L
D
A
R
------
N
-------------
Q
V
Y
N
I
A
V
G
G
--
R
T
S
L
N
Q
L
F
F
A
L
R
D
G
L
A
E
N
G
V
-------
S
Y
H
R
E
P
V
Y
R
D
F
R
E
G
D
V
R
H
S
L
A
D
I
S
K
A
A
K
L
L
G
Y
A
P
K
Y
-
D
V
S
A
G
V
A
L
A
M
P
W
Y
I
M
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
56.19
24%
-46
- C1 -
-
1Z45
3
GAL10_YEAST
A:
[11-699]
-------
S
K
I
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
V
E
L
I
E
--
N
G
Y
D
C
V
V
A
D
N
L
S
N
--
S
T
Y
D
S
V
A
R
-
L
E
V
-
L
T
K
-
H
H
I
P
F
Y
E
V
---
D
L
C
D
R
K
G
L
E
K
V
F
K
E
Y
K
I
D
S
V
I
H
F
A
G
L
K
A
V
G
E
S
T
Q
I
P
L
R
Y
Y
H
N
N
I
L
G
T
V
V
L
L
E
L
M
Q
Q
Y
-
N
-
V
S
---------
K
F
V
F
S
S
S
A
-
T
-
V
Y
G
---------
D
A
T
R
F
P
N
---------------
M
IPI
P
E
E
C
P
L
G
P
T
N
P
Y
G
H
T
K
Y
A
I
E
N
I
L
N
D
L
Y
N
S
D
K
K
S
W
K
F
A
I
L
R
Y
F
N
P
I
G
A
HPSGLIGED
P
L
G
I
P
N
-------------
N
L
L
P
-------
Y
M
A
Q
V
A
---
V
--
G
RR
E
K
L
Y
I
F
R
------
D
G
T
P
I
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
Q
Y
L
E
A
Y
N
------
E
N
E
--------
G
L
C
R
E
W
N
L
G
S
G
K
--
G
S
T
V
F
E
V
Y
H
A
F
C
K
A
S
---------------
G
I
D
L
--
P
Y
V
L
N
----
L
T
A
K
P
D
R
A
K
R
E
L
K
W
Q
T
E
L
-
Q
V
E
D
S
C
K
D
L
W
K
W
T
T
E
N
P
F
G
Y
Q
L
RG
V
E
A
R
F
SAEDMRYDA
R
F
V
T
I
GAGTR
F
Q
A
T
F
A
NLGASIV
D
L
K
V
NGQSV
V
L
G
Y
EN
E
E
G
Y
L
NPDSAYIGATIGRYANRISKG
K
F
S
L
CN
K
D
Y
Q
L
TVNNGVNANHSSIGSFHR
K
R
F
L
G
P
I
I
Q
NPSKD
V
F
T
A
E
Y
M
L
I
D
N
EKDTEFP
G
D
L
L
V
T
I
Q
Y
T
V
N
VAQK
S
L
E
I
V
Y
K
G
K
L
TAGE
A
T
P
I
N
L
T
N
H
S
Y
F
N
LNKPYGDTIEG
T
E
I
M
V
RSK
K
S
V
D
V
D
KNMIPTG
N
I
V
D
R
EIATFNSTK
P
T
V
L
G
PKNP
Q
F
D
C
C
F
V
VDENAKPSQINTLNNELTLI
V
K
A
F
H
PDSN
I
T
L
E
V
L
S
TEP
T
Y
Q
F
Y
TGDFLSAGYEARQ
G
F
A
I
E
P
G
RYIDAINQENWKDCVTLKNG
E
T
Y
G
S
K
I
V
Y
R
F
S
19
PsiBlast_PDB
56.08
26%
-39
- C1 -
-
2HUN
1
?
A:
[6-311]
----------
L
L
V
T
G
G
M
G
F
I
G
S
N
F
I
R
Y
I
L
E
K
H
P
D
W
E
V
I
N
I
D
K
L
G
----
Y
G
S
N
P
A
N
-
L
K
D
-
L
E
D
D
P
R
Y
T
F
V
K
G
---
D
V
A
D
Y
E
L
V
K
E
L
V
R
K
--
V
D
G
V
V
H
L
A
A
E
S
H
V
D
R
S
I
S
S
P
E
I
F
L
H
S
N
V
I
G
T
Y
T
L
L
E
S
I
R
R
E
N
P
-
E
V
---------
R
F
V
H
V
S
T
D
-
E
-
V
Y
G
---------
D
I
L
K
G
S
F
---------------
T
---
E
N
D
R
L
-
M
P
S
S
P
Y
S
A
T
K
A
A
S
D
M
L
V
L
G
W
T
R
T
--
Y
N
L
N
A
S
I
T
R
C
T
N
N
Y
G
----------
P
Y
Q
F
P
E
--------
K
----
L
I
P
K
-------
T
I
I
R
A
S
---
L
--
G
--
L
K
I
P
I
Y
G
------
T
---
V
R
D
W
L
Y
V
E
D
H
V
R
A
I
E
L
V
L
L
K
G
E
S
R
E
---------------------
I
Y
N
I
S
A
G
E
--
E
K
T
N
L
E
V
V
K
I
I
L
R
L
M
G
K
G
---------
E
E
L
I
E
L
V
--
E
D
R
P
G
H
D
L
R
Y
S
L
D
S
W
K
I
T
R
D
L
K
W
R
P
K
Y
-
T
F
D
E
G
I
K
K
T
I
D
W
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
55.72
28%
-34
- C1 -
-
4ZRM
3
?
A:
[6-309]
----------
I
L
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
I
E
N
--
G
Y
G
V
I
V
V
D
N
--------
L
S
S
G
K
-
V
E
N
-
L
N
R
--
N
A
L
F
Y
E
Q
---
S
I
E
D
E
E
M
M
E
R
I
F
S
L
H
R
P
E
Y
V
F
H
L
A
A
Q
A
S
V
A
I
S
V
R
E
P
A
R
D
A
K
T
N
I
I
G
S
L
V
L
L
E
K
S
I
K
Y
-
G
-
V
K
---------
K
F
I
F
S
S
T
G
G
A
-
I
Y
G
---------
E
N
V
K
V
F
P
---------------
T
---
P
E
T
E
I
P
H
P
I
S
P
Y
G
I
A
K
Y
S
T
E
M
Y
L
E
F
F
A
R
E
--
Y
G
L
K
Y
T
V
L
R
Y
A
N
V
Y
G
----------
P
R
Q
D
P
----------------
Y
G
EAG
V
V
A
I
F
T
E
R
M
L
---
R
--
G
--
E
E
V
H
I
F
G
------
D
G
E
Y
V
R
D
Y
V
Y
V
D
D
V
V
R
A
N
L
L
A
M
----
E
K
G
------
D
N
E
------------
V
F
N
I
G
T
G
R
--
G
T
T
V
N
Q
L
F
K
L
L
K
E
--------
I
T
G
Y
D
K
E
P
V
Y
K
----
P
P
R
K
G
D
V
R
K
S
I
L
D
Y
T
K
A
K
E
K
L
G
W
E
P
K
V
-
S
L
E
E
G
L
K
L
T
V
E
Y
F
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
54.57
28%
-28
- C1 -
-
4ZRN
2
?
A:
[6-309]
----------
I
L
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
I
E
N
--
G
Y
G
V
I
V
V
D
N
--------
L
S
S
G
K
-
V
E
N
-
L
N
R
--
N
A
L
F
Y
E
Q
---
S
I
E
D
E
E
M
M
E
R
I
F
S
L
H
R
P
E
Y
V
F
H
L
A
A
Q
A
S
V
A
I
S
V
R
E
P
A
R
D
A
K
T
N
I
I
G
S
L
V
L
L
E
K
S
I
K
Y
-
G
-
V
K
---------
K
F
I
F
S
S
T
G
G
A
-
I
Y
G
---------
E
N
V
K
V
F
P
---------------
T
---
P
E
T
E
I
P
H
P
I
S
P
Y
G
I
A
K
Y
S
T
E
M
Y
L
E
F
F
A
R
E
--
Y
G
L
K
Y
T
V
L
R
Y
A
N
V
Y
G
----------
P
R
Q
D
P
----------------
Y
G
EAG
V
V
A
I
F
T
E
R
M
L
---
R
--
G
--
E
E
V
H
I
F
G
------
D
G
E
Y
V
R
D
Y
V
Y
V
D
D
V
V
R
A
N
L
L
A
M
----
E
K
G
------
D
N
E
------------
V
F
N
I
G
T
G
R
--
G
T
T
V
N
Q
L
F
K
L
L
K
E
--------
I
T
G
Y
D
K
E
P
V
Y
K
----
P
P
R
K
G
D
V
R
K
S
I
L
D
Y
T
K
A
K
E
K
L
G
W
E
P
K
V
-
S
L
E
E
G
L
K
L
T
V
E
Y
F
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
54.56
29%
-10
- C1 -
-
3RU9
2
GNE_PLESH
B:
[21-350]
---
L
I
F
S
P
K
T
W
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
K
L
L
K
--
L
N
Q
V
V
I
G
L
D
N
F
S
T
G
H
Q
Y
N
L
D
E
V
K
-
T
L
V
S
T
E
Q
W
S
R
F
C
F
I
E
G
---
D
I
R
D
L
T
T
C
E
Q
V
M
K
--
G
V
D
H
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
V
D
P
I
T
T
N
A
T
N
I
T
G
F
L
N
I
L
H
A
A
K
N
A
-
Q
-
V
Q
---------
S
F
T
Y
A
A
S
S
-
S
-
T
Y
G
---------
D
H
P
A
L
P
K
---------------
V
---
E
-
E
N
I
G
N
P
L
S
P
Y
A
V
T
K
Y
V
N
E
I
Y
A
Q
V
Y
A
R
T
--
Y
G
F
K
T
I
G
L
R
Y
F
N
V
F
G
----------
R
R
Q
D
P
N
--------
G
AYAA
V
I
P
K
-------
W
T
A
A
M
L
---
K
--
G
--
D
D
V
Y
I
N
G
------
D
G
E
T
S
R
D
F
C
Y
I
D
N
V
I
Q
M
N
I
L
S
A
L
A
K
D
----------------
S
---
A
K
D
N
I
Y
N
V
A
V
G
D
--
R
T
T
L
N
E
L
S
G
Y
I
Y
D
E
L
N
L
I
H
H
I
----------
K
Y
R
--
E
F
R
S
G
D
V
R
H
S
Q
A
D
V
T
K
A
I
D
L
L
K
Y
R
P
N
I
-
K
I
R
E
G
L
R
L
S
M
P
W
Y
V
R
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
54.18
30%
-12
- C1 -
-
1SB8
2
?
A:
[21-350]
-
K
E
L
P
A
Q
P
K
V
W
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
T
L
L
K
L
D
Q
--
K
V
V
G
L
D
N
F
A
T
G
H
Q
R
N
L
D
E
V
R
S
L
V
S
-
E
K
Q
W
S
N
F
K
F
I
Q
G
DIR
N
L
D
D
C
N
N
A
C
A
G
V
D
-----
Y
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
N
D
P
I
T
S
N
A
T
N
I
D
G
F
L
N
M
L
I
A
A
R
D
A
-
K
-
V
Q
---------
S
F
T
Y
A
A
S
S
-
S
-
T
Y
G
---------
D
H
P
G
L
P
----------------
K
---
V
E
D
T
I
G
K
P
L
S
P
Y
A
V
T
K
Y
V
N
E
L
Y
A
D
V
F
S
R
C
--
Y
G
F
S
T
I
G
L
R
Y
F
N
V
F
G
----------
R
R
Q
D
P
N
--------
G
----
A
Y
A
A
V
I
P
K
---
W
T
S
S
M
I
---
Q
--
G
--
D
D
V
Y
I
N
G
------
D
G
E
T
S
R
D
F
C
Y
I
E
N
T
V
Q
A
N
L
L
A
A
T
A
G
L
D
A
R
------
N
-------------
Q
V
Y
N
I
A
V
G
G
--
R
T
S
L
N
Q
L
F
F
A
L
R
D
G
L
A
E
N
G
V
-------
S
Y
H
R
E
P
V
Y
R
D
F
R
E
G
D
V
R
H
S
L
A
D
I
S
K
A
A
K
L
L
G
Y
A
P
K
Y
-
D
V
S
A
G
V
A
L
A
M
P
W
Y
I
M
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------