@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZN0: (2018-01-15 )
MMKKDAKIYVAGHRGMVGSAIVRELNRQGYNNIITRTHKELDLCRQDQVEEFFAEEKPDYVFLAAAKVGGIVANQSALADFMYDNMILEMNVIHSAWKNGCKKLQFLGSSCIYPRMAPQPMPESCLLTSELEKTNEAYALAKISGLKYCEFLNKQYGTDYISVMPTNLYGPNDNYHPTHSHVLPALIRRFHEAKEAGLPTVTCWGDGSPLREFLYVDDFANLCVFLMNNYSGDETVNAGTGKELSIKELTEIVAKIIGYEGEILWDTSKPNGTPRKLLDVSKATKLGWTYKTELEDGIRLSYEDFLNNPMRAER
Atome Classification :
(20 SA)
.........10........20....-....30-.....---..---.------------------.---------------40........50........60........70........80........90........100........110......-----.----------------120.......130.......140.......150..----.....160.......170.......180.......190.....-..200.......210.......220.....---------..230-------......--...240--.......250.......260.......270.......280.-.-.....290.......300.......310..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MMKK
D
A
K
I
Y
V
AGHRGM
V
G
S
A
I
V
R
E
L
-
N
RQG
Y
--
N
N
I
I
T
---
R
T
---
H
------------------
K
---------------
E
L
D
L
C
R
Q
D
Q
V
E
E
F
F
A
EEKP
D
Y
V
F
L
A
AAKV
G
G
IVA
N
Q
S
A
L
A
D
F
M
YD
N
M
I
L
E
M
N
V
I
H
S
A
W
K
N
G
-
C
K
K
L
Q
F
L
G
SSCIYPRMAP-----Q----------------PM
P
E
S
C
L
L
T
S
E
L
E
KTNE
A
Y
A
L
A
KISG
L
K
Y
C
E
F
L
N
K
----
Q
YGT
D
Y
I
S
VMPTNLYGPNDNYHP
T
H
S
H
V
L
P
A
L
I
R
R
F
H
E
A
K
EAG-L
P
T
V
T
CWGDG
S
P
L
R
E
F
L
Y
V
D
D
F
A
N
L
C
V
F
L
M
---------NNY---------SGDETV--NAGTGK--EL
S
I
K
E
L
T
E
I
V
A
K
I
IGYE
G
E
I
L
W
DTSKPNGT
P
R
K
L
L
D
VSKA-T-KL
G
W
T
Y
K
TELEDG
I
R
L
S
Y
E
D
FLNNPMRAER
47
HHSearch
94.61
54%
-66
- C1 -
-
1BSV
1
FCL_ECOLI
A:
[3-317]
----
K
Q
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
-
E
Q
R
G
D
--
V
E
L
V
L
---
R
T
---
R
------------------
D
---------------
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
-
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
-----
Q
----------------
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
----
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
N
-
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
---------
E
L
A
H
E
V
W
L
E
N
T
Q
P
M
L
S
H
I
--
N
V
G
T
G
V
--
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
V
V
F
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
-
H
-
Q
L
G
W
Y
H
E
I
S
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
D
----
50
HHSearch
94.12
54%
-61
- C1 -
-
1E6U
3
FCL_ECOLI
A:
[2-316]
---
A
K
Q
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
-
E
Q
R
G
D
--
V
E
L
V
L
---
R
T
---
R
------------------
D
---------------
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
-
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
-----
Q
----------------
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
----
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
K
-
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
---------
E
L
A
H
E
V
W
L
E
N
T
Q
P
M
L
S
H
I
--
N
V
G
T
G
V
--
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
V
V
F
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
-
H
-
Q
L
G
W
Y
H
E
I
S
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
-----
8
PsiBlast_PDB
93.78
52%
-62
- C1 -
-
1E7R
4
FCL_ECOLI
A:
[5-316]
------
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
-
E
Q
R
G
D
--
V
E
L
V
L
---
R
T
---
R
------------------
D
---------------
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
-
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
-----
Q
----------------
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
P
E
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
----
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
S
-
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
E
LA
H
E
V
W
L
E
N
T
Q
---------
P
M
L
S
H
I
--
N
V
G
T
G
V
--
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
V
V
F
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
-
H
-
Q
L
G
W
Y
H
E
I
S
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
-----
1
PsiBlast_PDB
93.32
53%
-66
- C1 -
-
1BSV
1
FCL_ECOLI
A:
[5-318]
------
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
-
E
Q
R
G
D
--
V
E
L
V
L
---
R
T
---
R
------------------
D
---------------
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
-
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
-----
Q
----------------
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
----
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
N
-
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
E
LA
H
E
V
W
L
E
N
T
Q
---------
P
M
L
S
H
I
--
N
V
G
T
G
V
--
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
V
V
F
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
-
H
-
Q
L
G
W
Y
H
E
I
S
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
D
R
---
2
PsiBlast_PDB
92.75
53%
-66
- C1 -
-
1FXS
1
FCL_ECOLI
A:
[5-318]
------
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
-
E
Q
R
G
D
--
V
E
L
V
L
---
R
T
---
R
------------------
D
---------------
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
-
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
-----
Q
----------------
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
----
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
N
-
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
E
LA
H
E
V
W
L
E
N
T
Q
---------
P
M
L
S
H
I
--
N
V
G
T
G
V
--
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
V
V
F
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
-
H
-
Q
L
G
W
Y
H
E
I
S
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
D
R
---
5
PsiBlast_PDB
92.74
53%
-63
- C1 -
-
1E6U
3
FCL_ECOLI
A:
[5-316]
------
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
-
E
Q
R
G
D
--
V
E
L
V
L
---
R
T
---
R
------------------
D
---------------
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
-
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
-----
Q
----------------
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
----
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
K
-
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
E
LA
H
E
V
W
L
E
N
T
Q
---------
P
M
L
S
H
I
--
N
V
G
T
G
V
--
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
V
V
F
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
-
H
-
Q
L
G
W
Y
H
E
I
S
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
-----
7
PsiBlast_PDB
92.72
52%
-66
- C1 -
-
1BWS
1
FCL_ECOLI
A:
[5-316]
------
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
-
E
Q
R
G
D
--
V
E
L
V
L
---
R
T
---
R
------------------
D
---------------
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
-
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
-----
Q
----------------
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
----
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
N
-
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
E
LA
H
E
V
W
L
E
N
T
Q
---------
P
M
L
S
H
I
--
N
V
G
T
G
V
--
D
C
T
I
R
D
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
V
V
F
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
-
H
-
Q
L
G
W
Y
H
E
I
S
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
-----
3
PsiBlast_PDB
92.38
53%
-67
- C1 -
-
1GFS
-
FCL_ECOLI
A:
[5-318]
------
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
-
E
Q
R
G
D
--
V
E
L
V
L
---
R
T
---
R
------------------
D
---------------
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
-
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
-----
Q
----------------
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
----
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
N
-
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
E
LA
H
E
V
W
L
E
N
T
Q
---------
P
M
L
S
H
I
--
N
V
G
T
G
V
--
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
V
V
F
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
-
H
-
Q
L
G
W
Y
H
E
I
S
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
D
R
---
6
PsiBlast_PDB
91.57
52%
-63
- C1 -
-
1E7Q
3
FCL_ECOLI
A:
[5-316]
------
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
-
E
Q
R
G
D
--
V
E
L
V
L
---
R
T
---
R
------------------
D
---------------
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
-
V
N
K
L
L
F
L
G
A
S
C
I
Y
P
K
L
A
K
-----
Q
----------------
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
----
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
S
-
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
E
LA
H
E
V
W
L
E
N
T
Q
---------
P
M
L
S
H
I
--
N
V
G
T
G
V
--
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
V
V
F
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
-
H
-
Q
L
G
W
Y
H
E
I
S
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
-----
4
PsiBlast_PDB
91.09
52%
-63
- C1 -
-
1E7S
3
FCL_ECOLI
A:
[5-316]
------
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
-
E
Q
R
G
D
--
V
E
L
V
L
---
R
T
---
R
------------------
D
---------------
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
-
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
-----
Q
----------------
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
P
Y
A
I
A
R
I
A
G
I
K
L
C
E
S
Y
N
R
----
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
S
-
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
E
LA
H
E
V
W
L
E
N
T
Q
---------
P
M
L
S
H
I
--
N
V
G
T
G
V
--
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
V
V
F
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
-
H
-
Q
L
G
W
Y
H
E
I
S
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
-----
56
HHSearch
63.51
31%
1
- C1 -
-
4B8W
2
FCL_HUMAN
A:
[3-317]
-
Y
F
Q
S
M
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
-
A
D
G
A
G
--
L
P
G
E
D
W
V
F
V
S
---
S
------------------
K
---------------
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
-
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
-----
Y
----------------
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
----
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
--
S
A
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
---------
R
E
Y
NE-------
V
E
P
I
I
L
--
S
V
G
E
E
D
--
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
L
-
R
T
Y
L
P
D
F
R
F
T
P
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
Y
E
Q
---
41
HHSearch
60.19
27%
-3
- C1 -
-
2C5A
13
GME_ARATH
A:
[27-344]
--
S
E
N
L
K
I
S
I
T
G
A
G
G
F
I
A
S
H
I
A
R
R
L
-
K
H
E
G
H
--
Y
-
V
I
A
---
S
D
---
W
------------------
K
KNEHMTEDMFCDEFH
L
V
D
L
R
V
M
E
N
C
L
K
V
T
--
E
G
V
D
H
V
F
N
L
A
A
D
M
G
G
M
G
F
I
Q
S
N
H
S
V
I
M
Y
N
N
T
M
I
S
F
N
M
I
E
A
A
R
I
N
G
-
I
K
R
F
F
Y
A
S
S
A
C
I
Y
P
E
F
K
Q
LETTN
V
----------------
S
L
K
E
S
D
A
W
--
P
A
E
P
-
Q
D
A
F
G
L
E
K
L
A
T
E
E
L
C
K
H
Y
N
K
----
D
F
G
I
E
C
R
I
G
R
F
H
N
I
Y
G
P
F
G
T
W
K
G
G
R
E
K
A
P
A
A
F
C
R
K
A
Q
----
T
S
-
T
D
R
F
E
M
W
G
D
G
L
Q
T
R
S
F
T
F
I
D
E
C
V
E
G
V
L
R
L
T
---------
K
S
----------
D
F
R
E
P
V
--
N
I
G
S
D
E
--
M
V
S
M
N
E
M
A
E
M
V
L
S
F
E
E
K
K
L
P
I
H
H
I
P
G
-
P
E
G
V
R
G
R
N
S
D
N
N
L
I
K
E
-
K
L
G
W
A
P
N
M
R
L
K
E
G
L
R
I
T
Y
F
W
I
K
E
Q
I
E
K
---
46
HHSearch
57.73
17%
-29
- C1 -
-
1ORR
2
RFBE_SALTI
B:
[2-339]
-----
A
K
L
L
I
T
G
G
C
G
F
L
G
S
N
L
A
S
F
A
-
L
S
Q
G
I
--
D
-
L
I
V
---
F
D
NLS
R
KG
A
T
D
N
L
H
W
L
S
S
L
G
N
F
E
F
V
---------------
H
G
D
I
R
N
K
N
D
V
T
R
L
I
T
K
Y
M
P
D
S
C
F
H
L
A
G
Q
V
A
M
T
T
S
-
I
D
N
P
C
M
D
F
E
I
N
V
G
G
T
L
N
L
L
E
A
V
R
Q
Y
N
S
N
C
N
I
I
Y
S
S
T
N
K
V
Y
G
D
L
E
Q
-----
Y
K
Y
N
E
T
ET
R
Y
T
C
VDKPN
G
Y
D
E
S
T
Q
----
L
D
F
-
H
S
P
Y
G
C
S
K
G
A
A
D
Q
Y
M
L
D
Y
A
R
----
I
F
G
L
N
T
V
V
F
R
H
S
S
M
Y
G
G
R
Q
F
A
T
Y
-
D
Q
G
W
V
G
W
F
C
Q
K
A
V
E
I
K
-
N
G
I
N
K
P
F
T
I
S
G
N
G
K
Q
V
R
D
V
L
H
A
E
D
M
I
S
L
Y
F
T
A
L
---------
A
N
V
SK-------
I
R
G
N
A
F
--
N
I
G
G
T
I
VN
S
L
S
L
L
E
L
F
K
L
L
E
D
Y
C
N
I
D
M
R
F
T
N
L
P
V
R
E
S
D
Q
R
V
F
V
A
D
I
K
K
I
T
N
-
A
I
D
W
S
P
K
V
S
A
K
D
G
V
Q
K
M
Y
D
W
T
S
S
I
------
35
PsiBlast_CBE
55.98
32%
-7
- C1 -
-
4B8Z
2
FCL_HUMAN
D:
[8-288]
-----
M
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
---
V
S
---
S
------------------
K
---------------
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
-
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
-----
Y
----------------
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
----
R
M
I
D
V
Q
N
R
AYFQ
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
--
S
A
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
---------
R
E
Y
---------
N
E
V
E
P
I
IL
S
V
G
E
E
D
--
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
----------------------------------
29
PsiBlast_CBE
55.80
32%
-2
- C1 -
-
4BL5
2
FCL_HUMAN
D:
[24-303]
------
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
---
V
S
---
S
------------------
K
---------------
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
-
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
-----
Y
----------------
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
----
R
M
I
D
V
Q
N
R
AYFQ
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
--
S
A
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
---------
R
E
Y
---------
N
E
V
E
P
I
IL
S
V
G
E
E
D
--
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
----------------------------------
11
PsiBlast_PDB
55.71
32%
-8
- C1 -
-
4B8Z
2
FCL_HUMAN
A:
[8-288]
-----
M
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
---
V
S
---
S
------------------
K
---------------
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
-
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
-----
Y
----------------
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
----
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
--
S
A
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
---------
R
E
Y
---------
N
E
V
E
P
I
I
L
S
V
G
E
E
D
--
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
----------------------------------
13
PsiBlast_PDB
55.64
32%
-4
- C1 -
-
4B8W
2
FCL_HUMAN
A:
[5-287]
---
Q
S
M
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
---
V
S
---
S
------------------
K
---------------
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
-
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
-----
Y
----------------
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
----
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
--
S
A
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
---------
R
E
Y
---------
N
E
V
E
P
I
I
L
S
V
G
E
E
D
--
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
----------------------------------
21
PsiBlast_CBE
55.47
32%
-2
- C1 -
-
4BL5
11
FCL_HUMAN
L:
[24-303]
------
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
---
V
S
---
S
------------------
K
---------------
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
-
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
-----
Y
----------------
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
----
R
M
I
D
V
Q
N
R
AYFQ
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
--
S
A
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
---------
R
E
Y
---------
N
E
V
E
P
I
IL
S
V
G
E
E
D
--
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
----------------------------------
37
PsiBlast_CBE
54.95
32%
-9
- C1 -
-
4B8Z
2
FCL_HUMAN
B:
[6-288]
---
Q
S
M
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
---
V
S
---
S
------------------
K
---------------
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
-
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
-----
Y
----------------
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
----
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
--
S
A
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
---------
R
E
Y
---------
N
E
V
E
P
I
I
L
S
V
G
E
E
D
--
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
----------------------------------
32
PsiBlast_CBE
54.74
32%
-7
- C1 -
-
4BKP
2
FCL_HUMAN
D:
[24-303]
------
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
---
V
S
---
S
------------------
K
---------------
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
-
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
-----
Y
----------------
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
----
R
M
I
D
V
Q
N
R
AYFQ
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
--
S
A
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
---------
R
E
Y
---------
N
E
V
E
P
I
IL
S
V
G
E
E
D
--
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
----------------------------------