@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZT0: (2018-01-16 )
MIFVPNENHDPRINLAIEQYLLQEMPLDEPILLFYINEPSIIIGRNQNTLEEINRDYVEENGIHVVRRLSGGGAVYHDFGNLNFSFIMPDDGDSFRDFAKVTQPIIQALHELGVAGAELKGRNDLVIDGMKFSGNAMYATNGRMFAHGTIMFDSDINEVVNALKVKKDKIESKGIKSIRSRVTNIKPFLPEEKQKMTTEEFRQEILLKIFGVESVEEVKTYELTDEDWKKINRISEEYYRNWDWNYGKSPDFNFSRQKRFSIGSIEVHLNVSEGMIKEAKIFGDFFGLGDISDVEKKLVGQKYDKASLSKIVSQIDVKKYFGAIEPEELLTLLY
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110....-...120......----.130--.........140.......150.......160.......170.......180.......190.......200.......210......--.220...---....230.......240.........250.......260.......270.......280.....-..290.......300.......310.......320.......330..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
I
FVPNENHDP
R
I
N
L
A
I
E
Q
Y
L
L
Q
EMPLDE
P
I
L
L
F
Y
INEP
S
I
I
I
GRNQ
N
T
L
E
E
I
N
R
D
Y
V
EENG
I
H
V
V
R
RLSGG
G
A
V
Y
H
DFGN
L
N
F
S
F
I
MPDDG
D
S
F
R
D
F
A
K
V
T
Q
P
I
I
Q
A
L
H
E
LGVAG-AELKGRN
D
L
V
I
D
----
G
M
----KFSG
N
A
M
Y
A
TN
G
R
M
F
A
H
G
T
I
M
FDS
D
I
N
E
V
V
N
A
L
K
V
K
K
D
KI
E
S
K
G
I
K
S
I
R
S
R
VTNIKPFL
P
E
E
K
Q
KM
T
T
E
E
F
R
Q
E
I
L
L
K
I
FGV
E
S
V
E
EV--K
T
Y
EL
T
D
---
E
D
W
K
K
I
N
R
I
S
E
E
Y
Y
R--NWDWNYGKSPDFNF
S
R
Q
K
R
FSI
G
S
I
E
V
H
L
NVSEG
M
I
K
E
A
K
I
F
G
D
FFG-LG
D
I
S
D
V
E
K
K
L
VGQKY
D
K
A
S
L
S
K
I
V
S
Q
I
D
V
K
K
Y
FGAI
E
P
E
E
L
L
T
L
LY
2
PsiBlast_PDB
99.14
81%
-116
- C1 -
-
5ICH
1
?
A:
[19-352]
M
I
F
V
P
N
E
N
N
D
P
R
V
N
L
A
I
E
T
Y
L
L
T
E
M
P
L
D
E
P
I
L
L
F
Y
I
N
E
P
S
I
I
I
G
R
N
Q
N
T
I
E
E
I
N
K
E
Y
V
D
E
H
G
I
H
V
V
R
R
L
S
G
G
G
A
V
Y
H
D
H
G
N
L
N
F
S
F
I
M
P
D
D
G
N
S
F
R
D
F
A
K
V
T
Q
P
I
I
Q
A
L
H
D
L
G
V
E
G
-
A
E
L
K
G
R
N
D
L
V
I
N
----
D
M
----
K
F
S
G
N
A
M
Y
A
T
N
G
R
M
F
A
H
G
T
L
M
F
D
S
D
I
D
E
V
V
N
T
L
K
----------------
R
V
T
N
I
K
P
F
L
S
E
D
K
Q
E
M
T
T
E
E
F
R
Q
E
I
L
L
K
I
F
G
V
D
S
I
D
Q
V
--
K
T
Y
E
L
T
D
---
Q
D
W
A
A
I
N
K
I
S
E
Q
Y
Y
R
--
N
W
D
W
N
Y
G
K
S
P
A
F
N
L
E
R
R
H
R
F
P
I
G
S
I
E
M
K
M
N
V
A
D
G
A
I
Q
E
I
K
I
F
G
D
F
F
G
-
L
G
E
I
K
D
V
E
D
I
L
T
G
V
K
Y
D
K
A
S
L
E
E
A
I
D
Q
I
D
V
K
K
Y
F
G
N
I
E
K
E
D
L
L
G
L
I
Y
21
PsiBlast_CBE
99.03
81%
-114
- C1 -
-
5ICL
1
?
B:
[19-352]
M
I
F
V
P
N
E
N
N
D
P
R
V
N
L
A
I
E
T
Y
L
L
T
E
M
P
L
D
E
P
I
L
L
F
Y
I
N
E
P
S
I
I
I
G
R
N
Q
N
T
I
E
E
I
N
K
E
Y
V
D
E
H
G
I
H
V
V
R
R
L
S
G
G
G
A
V
Y
H
D
H
G
N
L
N
F
S
F
I
M
P
D
D
G
N
S
F
R
D
F
A
K
V
T
Q
P
I
I
Q
A
L
H
D
L
G
V
E
G
-
A
E
L
K
G
R
N
D
L
V
I
N
----
D
M
----
K
F
S
G
N
A
M
Y
A
T
N
G
R
M
F
A
H
G
T
L
M
F
D
S
D
I
D
E
V
V
N
T
L
K
----------------
R
V
T
N
I
K
P
F
L
S
E
D
K
Q
E
M
T
T
E
E
F
R
Q
E
I
L
L
K
I
F
G
V
D
S
I
D
Q
V
--
K
T
Y
E
L
T
D
---
Q
D
W
A
A
I
N
K
I
S
E
Q
Y
Y
R
--
N
W
D
W
N
Y
G
K
S
P
A
F
N
L
E
R
R
H
R
F
P
I
G
S
I
E
M
K
M
N
V
A
D
G
A
I
Q
E
I
K
I
F
G
D
F
F
G
-
L
G
E
I
K
D
V
E
D
I
L
T
G
V
K
Y
D
K
A
S
L
E
E
A
I
D
Q
I
D
V
K
K
Y
F
G
N
I
E
K
E
D
L
L
G
L
I
Y
1
PsiBlast_PDB
98.29
81%
-116
- C1 -
-
5IBY
1
?
A:
[19-352]
M
I
F
V
P
N
E
N
N
D
P
R
V
N
L
A
I
E
T
Y
L
L
T
E
M
P
L
D
E
P
I
L
L
F
Y
I
N
E
P
S
I
I
I
G
R
N
Q
N
T
I
E
E
I
N
K
E
Y
V
D
E
H
G
I
H
V
V
R
R
L
S
G
G
G
A
V
Y
H
D
H
G
N
L
N
F
S
F
I
M
P
D
D
G
N
S
F
R
D
F
A
K
V
T
Q
P
I
I
Q
A
L
H
D
L
G
V
E
G
-
A
E
L
K
G
R
N
D
L
V
I
N
----
D
M
----
K
F
S
G
N
A
M
Y
A
T
N
G
R
M
F
A
H
G
T
L
M
F
D
S
D
I
D
E
V
V
N
T
L
-----------------
R
V
T
N
I
K
P
F
L
S
E
D
K
Q
E
M
T
T
E
E
F
R
Q
E
I
L
L
K
I
F
G
V
D
S
I
D
Q
V
--
K
T
Y
E
L
T
D
---
Q
D
W
A
A
I
N
K
I
S
E
Q
Y
Y
R
--
N
W
D
W
N
Y
G
K
S
P
A
F
N
L
E
R
R
H
R
F
P
I
G
S
I
E
M
K
M
N
V
A
D
G
A
I
Q
E
I
K
I
F
G
D
F
F
G
-
L
G
E
I
K
D
V
E
D
I
L
T
G
V
K
Y
D
K
A
S
L
E
E
A
I
D
Q
I
D
V
K
K
Y
F
G
N
I
E
K
E
D
L
L
G
L
I
Y
3
PsiBlast_PDB
96.98
81%
-118
- C1 -
-
5ICL
1
?
A:
[19-352]
M
I
F
V
P
N
E
N
N
D
P
R
V
N
L
A
I
E
T
Y
L
L
T
E
M
P
L
D
E
P
I
L
L
F
Y
I
N
E
P
S
I
I
I
G
R
N
Q
N
T
I
E
E
I
N
K
E
Y
V
D
E
H
G
I
H
V
V
R
R
L
S
G
G
G
A
V
Y
H
D
H
G
N
L
N
F
S
F
I
M
P
D
D
G
N
S
F
R
D
F
A
K
V
T
Q
P
I
I
Q
A
L
H
D
L
G
V
E
G
-
A
E
L
K
G
R
N
D
L
V
I
N
----
D
M
----
K
F
S
G
N
A
M
Y
A
T
N
G
R
M
F
A
H
G
T
L
M
F
D
S
D
I
D
E
V
V
N
T
L
-----------------
R
V
T
N
I
K
P
F
L
S
E
D
K
Q
E
M
T
T
E
E
F
R
Q
E
I
L
L
K
I
F
G
V
D
S
I
D
Q
V
--
K
T
Y
E
L
T
D
---
Q
D
W
A
A
I
N
K
I
S
E
Q
Y
Y
R
--
N
W
D
W
N
Y
G
K
S
P
A
F
N
L
E
R
R
H
R
F
P
I
G
S
I
E
M
K
M
N
V
A
D
G
A
I
Q
E
I
K
I
F
G
D
F
F
G
-
L
G
E
I
K
D
V
E
D
I
L
T
G
V
K
Y
D
K
A
S
L
E
E
A
I
D
Q
I
D
V
K
K
Y
F
G
N
I
E
K
E
D
L
L
G
L
I
Y
4
PsiBlast_PDB
96.93
81%
-118
- C1 -
-
5IDH
1
?
A:
[19-352]
M
I
F
V
P
N
E
N
N
D
P
R
V
N
L
A
I
E
T
Y
L
L
T
E
M
P
L
D
E
P
I
L
L
F
Y
I
N
E
P
S
I
I
I
G
R
N
Q
N
T
I
E
E
I
N
K
E
Y
V
D
E
H
G
I
H
V
V
R
R
L
S
G
G
G
A
V
Y
H
D
H
G
N
L
N
F
S
F
I
M
P
D
D
-----
D
F
A
K
V
T
Q
P
I
I
Q
A
L
H
D
L
G
V
E
G
-
A
E
L
K
G
R
N
D
L
V
I
N
----
D
M
----
K
F
S
G
N
A
M
Y
A
T
N
G
R
M
F
A
H
G
T
L
M
F
D
S
D
I
D
E
V
V
N
T
L
K
----------------
R
V
T
N
I
K
P
F
L
S
E
D
K
Q
E
M
T
T
E
E
F
R
Q
E
I
L
L
K
I
F
G
V
D
S
I
D
Q
V
--
K
T
Y
E
L
T
D
---
Q
D
W
A
A
I
N
K
I
S
E
Q
Y
Y
R
--
N
W
D
W
N
Y
G
K
S
P
A
F
N
L
E
R
R
H
R
F
P
I
G
S
I
E
M
K
M
N
V
A
D
G
A
I
Q
E
I
K
I
F
G
D
F
F
G
-
L
G
E
I
K
D
V
E
D
I
L
T
G
V
K
Y
D
K
A
S
L
E
E
A
I
D
Q
I
D
V
K
K
Y
F
G
N
I
E
K
E
D
L
L
G
L
I
Y
22
PsiBlast_CBE
95.87
81%
-120
- C1 -
-
5ICH
1
?
B:
[19-352]
M
I
F
V
P
N
E
N
N
D
P
R
V
N
L
A
I
E
T
Y
L
L
T
E
M
P
L
D
E
P
I
L
L
F
Y
I
N
E
P
S
I
I
I
G
R
N
Q
N
T
I
E
E
I
N
K
E
Y
V
D
E
H
G
I
H
V
V
R
R
L
S
G
G
G
A
V
Y
H
D
H
G
N
L
N
F
S
F
I
M
P
D
D
------
F
A
K
V
T
Q
P
I
I
Q
A
L
H
D
L
G
V
E
G
-
A
E
L
K
G
R
N
D
L
V
I
N
----
D
M
----
K
F
S
G
N
A
M
Y
A
T
N
G
R
M
F
A
H
G
T
L
M
F
D
S
D
I
D
E
V
V
N
T
L
------------------
V
T
N
I
K
P
F
L
S
E
D
K
Q
E
M
T
T
E
E
F
R
Q
E
I
L
L
K
I
F
G
V
D
S
I
D
Q
V
--
K
T
Y
E
L
T
D
---
Q
D
W
A
A
I
N
K
I
S
E
Q
Y
Y
R
--
N
W
D
W
N
Y
G
K
S
P
A
F
N
L
E
R
R
H
R
F
P
I
G
S
I
E
M
K
M
N
V
A
D
G
A
I
Q
E
I
K
I
F
G
D
F
F
G
-
L
G
E
I
K
D
V
E
D
I
L
T
G
V
K
Y
D
K
A
S
L
E
E
A
I
D
Q
I
D
V
K
K
Y
F
G
N
I
E
K
E
D
L
L
G
L
I
Y
37
HHSearch
85.59
81%
-12
- C1 -
-
5ICL
1
?
B:
[19-352]
M
I
F
V
P
N
E
N
N
D
P
R
V
N
L
A
I
E
T
Y
L
L
T
E
M
P
L
D
E
P
I
L
L
F
Y
I
N
E
P
S
I
I
I
G
R
N
Q
N
T
I
E
E
I
N
K
E
Y
V
D
E
H
G
I
H
V
V
R
R
L
S
G
G
G
A
V
Y
H
D
H
G
N
L
N
F
S
F
I
M
P
D
D
G
N
S
F
R
D
F
A
K
V
T
Q
P
I
I
Q
A
L
H
D
L
G
V
-
E
G
A
E
L
K
G
R
N
D
L
V
I
N
----
D
M
----
K
F
S
G
N
A
M
Y
A
T
N
G
R
M
F
A
H
G
T
L
M
F
D
S
D
I
D
E
V
V
N
T
L
K
----------------
R
V
T
N
I
K
P
F
L
S
E
D
K
Q
E
M
T
T
E
E
F
R
Q
E
I
L
L
K
I
F
G
V
D
S
I
D
Q
V
--
K
T
Y
E
L
T
D
---
Q
D
W
A
A
I
N
K
I
S
E
Q
Y
Y
R
--
N
W
D
W
N
Y
G
K
S
P
A
F
N
L
E
R
R
H
R
F
P
I
G
S
I
E
M
K
M
N
V
A
D
G
A
I
Q
E
I
K
I
F
G
D
F
F
G
-
L
G
E
I
K
D
V
E
D
I
L
T
G
V
K
Y
D
K
A
S
L
E
E
A
I
D
Q
I
D
V
K
K
Y
F
G
N
I
E
K
E
D
L
L
G
L
I
Y
38
HHSearch
82.53
81%
-9
- C1 -
-
5IDH
1
?
A:
[19-352]
M
I
F
V
P
N
E
N
N
D
P
R
V
N
L
A
I
E
T
Y
L
L
T
E
M
P
L
D
E
P
I
L
L
F
Y
I
N
E
P
S
I
I
I
G
R
N
Q
N
T
I
E
E
I
N
K
E
Y
V
D
E
H
G
I
H
V
V
R
R
L
S
G
G
G
A
V
Y
H
D
H
G
N
L
N
F
S
F
I
M
P
D
D
-----
D
F
A
K
V
T
Q
P
I
I
Q
A
L
H
D
L
G
V
-
E
G
A
E
L
K
G
R
N
D
L
V
I
N
----
D
M
----
K
F
S
G
N
A
M
Y
A
T
N
G
R
M
F
A
H
G
T
L
M
F
D
S
D
I
D
E
V
V
N
T
L
K
----------------
R
V
T
N
I
K
P
F
L
S
E
D
K
Q
E
M
T
T
E
E
F
R
Q
E
I
L
L
K
I
F
G
V
D
S
I
D
Q
V
--
K
T
Y
E
L
T
D
---
Q
D
W
A
A
I
N
K
I
S
E
Q
Y
Y
R
--
N
W
D
W
N
Y
G
K
S
P
A
F
N
L
E
R
R
H
R
F
P
I
G
S
I
E
M
K
M
N
V
A
D
G
A
I
Q
E
I
K
I
F
G
D
F
F
G
-
L
G
E
I
K
D
V
E
D
I
L
T
G
V
K
Y
D
K
A
S
L
E
E
A
I
D
Q
I
D
V
K
K
Y
F
G
N
I
E
K
E
D
L
L
G
L
I
Y
40
HHSearch
81.49
48%
-98
- C1 -
-
1VQZ
18
?
A:
[13-340]
M
K
Y
I
I
N
H
S
N
D
T
A
F
N
I
A
L
E
E
Y
A
F
K
H
L
L
D
E
D
Q
I
F
L
L
W
I
N
K
P
S
I
I
V
G
R
H
Q
N
T
I
E
E
I
N
R
D
Y
V
R
E
N
G
I
E
V
V
R
R
I
S
G
G
G
A
V
Y
H
D
L
N
N
L
N
Y
T
I
I
S
K
E
D
E
N
K
A
F
D
F
K
S
F
S
T
P
V
I
N
T
L
A
Q
L
G
V
-
K
-
A
E
F
T
G
R
N
D
L
E
I
D
----
G
K
----
K
F
C
G
N
A
Q
A
Y
I
N
G
R
I
M
H
H
G
C
L
L
F
D
V
D
L
S
V
L
A
N
A
L
K
V
S
K
D
K
F
E
S
K
G
V
K
S
V
R
A
R
V
T
N
I
I
N
E
L
P
K
---
K
I
T
V
E
K
F
R
D
L
L
L
E
Y
M
K
K
E
Y
P
E
M
----
T
E
Y
V
F
S
E
---
E
E
L
A
E
I
N
R
I
K
D
T
K
F
G
--
T
W
D
W
N
Y
G
K
S
P
E
F
N
V
R
R
G
I
K
F
T
S
G
K
V
E
V
F
A
N
V
T
E
S
K
I
Q
D
I
K
I
Y
G
D
F
F
G
-
I
E
D
V
A
A
V
E
D
V
L
R
G
V
K
Y
E
R
E
D
V
L
K
A
L
K
T
I
D
I
T
R
Y
F
A
G
I
S
R
E
E
I
A
E
A
V
V
6
PsiBlast_PDB
80.98
48%
-94
- C1 -
-
1VQZ
18
?
A:
[15-335]
--
Y
I
I
N
H
S
N
D
T
A
F
N
I
A
L
E
E
Y
A
F
K
H
L
L
D
E
D
Q
I
F
L
L
W
I
N
K
P
S
I
I
V
G
R
H
Q
N
T
I
E
E
I
N
R
D
Y
V
R
E
N
G
I
E
V
V
R
R
I
S
G
G
G
A
V
Y
H
D
L
N
N
L
N
Y
T
I
I
S
K
E
D
E
N
K
A
F
D
F
K
S
F
S
T
P
V
I
N
T
L
A
Q
L
G
V
K
--
A
E
F
T
G
R
N
D
L
E
I
D
----
G
K
----
K
F
C
G
N
A
Q
A
Y
I
N
G
R
I
M
H
H
G
C
L
L
F
D
V
D
L
S
V
L
A
N
A
L
K
V
S
K
D
K
F
E
S
K
G
V
K
S
V
R
A
R
V
T
N
I
I
N
E
L
P
---
K
K
I
T
V
E
K
F
R
D
--
L
L
L
E
Y
M
K
K
E
Y
P
E
M
--
T
E
Y
V
F
S
E
---
E
E
L
A
E
I
N
R
I
K
D
T
K
F
G
--
T
W
D
W
N
Y
G
K
S
P
E
F
N
V
R
R
G
I
K
F
T
S
G
K
V
E
V
F
A
N
V
T
E
S
K
I
Q
D
I
K
I
Y
G
D
F
F
G
-
I
E
D
V
A
A
V
E
D
V
L
R
G
V
K
Y
E
R
E
D
V
L
K
A
L
K
T
I
D
I
T
R
Y
F
A
G
I
S
R
E
E
I
-----
5
PsiBlast_PDB
78.67
45%
-62
- C1 -
-
5IJ6
1
?
A:
[19-353]
M
R
Y
V
I
M
Q
S
R
D
I
R
E
N
L
A
T
E
D
Y
L
L
N
T
L
S
F
E
E
P
L
V
L
F
Y
I
Q
E
P
C
V
I
L
G
R
N
Q
N
A
Y
E
E
I
D
L
A
Y
A
R
E
K
G
I
V
I
T
R
R
L
S
G
G
G
A
V
Y
D
D
L
G
N
V
S
F
S
F
V
V
Q
E
G
H
Q
A
F
G
D
F
K
A
F
T
K
P
I
I
E
A
L
H
K
M
G
A
T
G
-
A
E
I
S
G
R
N
D
L
L
I
D
----
G
K
----
K
F
S
G
N
A
M
Y
T
K
K
G
K
M
Y
T
H
G
T
L
M
Y
D
V
D
L
A
E
V
Q
R
V
L
T
----------------
R
V
T
N
L
R
P
Y
L
D
E
K
Y
Q
Q
L
T
I
E
E
F
R
N
R
L
L
M
E
L
F
D
V
E
S
L
T
E
I
AE
K
E
Y
V
L
T
K
---
A
D
Q
Q
E
I
R
K
L
V
A
E
V
Y
G
--
N
E
A
W
I
F
G
E
A
P
K
F
T
I
K
K
E
E
K
F
K
G
G
I
V
D
A
R
L
T
V
E
K
G
K
I
I
E
L
T
I
Y
G
D
Y
F
A
-
K
K
E
T
T
E
I
V
A
A
L
L
G
V
D
Y
Q
Y
S
S
I
W
Q
A
L
A
A
F
N
F
E
D
Y
F
V
N
I
T
K
E
E
F
V
H
L
L
-
39
HHSearch
73.22
46%
-23
- C1 -
-
5IJ6
1
?
A:
[19-354]
M
R
Y
V
I
M
Q
S
R
D
I
R
E
N
L
A
T
E
D
Y
L
L
N
T
L
S
F
E
E
P
L
V
L
F
Y
I
Q
E
P
C
V
I
L
G
R
N
Q
N
A
Y
E
E
I
D
L
A
Y
A
R
E
K
G
I
V
I
T
R
R
L
S
G
G
G
A
V
Y
D
D
L
G
N
V
S
F
S
F
V
V
Q
E
G
H
Q
A
F
G
D
F
K
A
F
T
K
P
I
I
E
A
L
H
K
M
G
A
-
T
G
A
E
I
S
G
R
N
D
L
L
I
D
----
G
K
----
K
F
S
G
N
A
M
Y
T
K
K
G
K
M
Y
T
H
G
T
L
M
Y
D
V
D
L
A
E
V
Q
R
V
L
T
----------------
R
V
T
N
L
R
P
Y
L
D
E
K
Y
Q
Q
L
T
I
E
E
F
R
N
R
L
L
M
E
L
F
D
V
E
S
L
T
E
I
AE
K
E
Y
V
L
T
K
---
A
D
Q
Q
E
I
R
K
L
V
A
E
V
Y
G
--
N
E
A
W
I
F
G
E
A
P
K
F
T
I
K
K
E
E
K
F
K
G
G
I
V
D
A
R
L
T
V
E
K
G
K
I
I
E
L
T
I
Y
G
D
Y
F
A
K
K
E
-
T
T
E
I
V
A
A
L
L
G
V
D
Y
Q
Y
S
S
I
W
Q
A
L
A
A
F
N
F
E
D
Y
F
V
N
I
T
K
E
E
F
V
H
L
L
V
41
HHSearch
63.37
33%
-32
- C1 -
-
1X2G
-
LPLA_ECOLI
C:
[3-332]
L
R
L
L
I
S
D
S
Y
D
P
W
F
N
L
A
V
E
E
C
I
F
R
Q
M
P
A
T
Q
R
V
L
F
L
W
R
N
A
D
T
V
V
I
G
R
A
Q
N
P
W
K
E
C
N
T
R
R
M
E
E
D
N
V
R
L
A
R
R
S
S
G
G
G
A
V
F
H
D
L
G
N
T
C
F
T
F
M
A
G
K
P
E
---
Y
D
K
T
I
S
T
S
I
V
L
N
A
L
N
A
L
G
V
-
S
-
A
E
A
S
G
R
N
D
L
V
V
K
T
VEG
D
R
----
K
V
S
G
S
A
Y
R
E
T
K
D
R
G
F
H
H
G
T
L
L
L
N
A
D
L
S
R
L
A
N
Y
L
N
P
D
K
K
K
L
A
A
K
G
I
T
S
V
R
S
R
V
T
N
L
T
E
L
L
P
G
----
I
T
H
E
Q
V
C
E
A
I
T
E
A
F
F
A
H
Y
G
E
R
V
E
---
A
E
I
I
S
P
NKT
P
D
L
P
N
-
F
A
E
T
F
A
R
Q
S
--
S
W
E
W
N
F
G
Q
A
P
A
F
S
H
L
L
D
E
R
F
T
W
G
G
V
E
L
H
F
D
V
E
K
G
H
I
T
R
A
Q
V
F
T
D
S
L
N
-
P
A
P
L
E
A
L
A
G
R
L
Q
G
C
L
Y
R
A
D
M
L
Q
Q
E
C
E
A
L
L
V
D
F
P
E
Q
E
K
E
L
R
E
L
S
A
W
M
-
42
HHSearch
61.42
33%
-27
- C1 -
-
3A7R
1
LPLA_ECOLI
A:
[3-332]
L
R
L
L
I
S
D
S
Y
D
P
W
F
N
L
A
V
E
E
C
I
F
R
Q
M
P
A
T
Q
R
V
L
F
L
W
R
N
A
D
T
V
V
I
G
R
A
Q
N
P
W
K
E
C
N
T
R
R
M
E
E
D
N
V
R
L
A
R
R
S
S
G
G
G
A
V
F
H
D
L
G
N
T
C
F
T
F
M
A
G
K
P
E
---
Y
D
K
T
I
S
T
S
I
V
L
N
A
L
N
A
L
G
V
-
S
-
A
E
A
S
G
R
N
D
L
V
V
K
T
VE
G
D
R
----
K
V
S
G
S
A
Y
R
E
T
K
D
R
G
F
H
H
G
T
L
L
L
N
A
D
L
S
R
L
A
N
Y
L
N
P
D
K
K
K
L
A
A
K
G
I
T
S
V
R
S
R
V
T
N
L
T
E
L
L
P
G
----
I
T
H
E
Q
V
C
E
A
I
T
E
A
F
F
A
H
Y
G
E
R
V
E
---
A
E
I
I
S
P
NKT
P
D
L
P
N
-
F
A
E
T
F
A
R
Q
S
--
S
W
E
W
N
F
G
Q
A
P
A
F
S
H
L
L
D
E
R
F
T
W
G
G
V
E
L
H
F
D
V
E
K
G
H
I
T
R
A
Q
V
F
T
D
S
L
N
-
P
A
P
L
E
A
L
A
G
R
L
Q
G
C
L
Y
R
A
D
M
L
Q
Q
E
C
E
A
L
L
V
D
F
P
E
Q
E
K
E
L
R
E
L
S
A
W
M
-
24
PsiBlast_CBE
59.35
33%
-42
- C1 -
-
4TVY
2
LPLA_ECOLI
B:
[12-306]
-----
S
D
S
Y
D
P
W
F
N
L
A
V
A
E
C
I
F
R
Q
M
P
A
T
Q
R
V
L
F
L
W
R
N
A
D
T
V
V
I
G
R
A
Q
N
P
W
K
E
C
N
T
R
R
M
E
E
D
N
V
R
L
A
R
R
S
S
G
G
G
A
V
F
H
D
L
G
N
T
C
F
T
F
M
A
---
G
K
P
E
Y
D
K
T
I
S
T
S
I
V
L
N
A
L
N
A
L
G
V
S
--
A
E
A
S
G
R
N
D
L
V
V
K
----
T
V
EGDR
K
V
S
G
S
A
Y
R
E
T
K
D
R
G
A
H
G
G
T
L
L
L
N
A
D
L
S
R
L
A
N
Y
L
N
----------------
R
V
T
N
L
T
E
L
L
P
G
-----
I
T
H
E
Q
V
C
E
A
I
T
E
A
F
F
A
H
Y
G
E
R
V
--
E
A
E
I
I
S
P
---
N
K
T
P
D
L
P
N
F
A
E
T
F
A
R
Q
S
S
W
E
W
N
F
G
Q
A
P
A
F
S
H
L
L
D
E
R
F
T
W
G
G
V
E
L
H
F
D
V
E
K
G
H
I
T
R
A
Q
V
F
T
D
S
L
N
-
P
A
P
L
E
A
L
A
G
R
L
Q
G
C
L
Y
-------------------------------
9
PsiBlast_PDB
58.53
33%
-31
- C1 -
-
1X2G
-
LPLA_ECOLI
A:
[8-309]
-----
S
D
S
Y
D
P
W
F
N
L
A
V
E
E
C
I
F
R
Q
M
P
A
T
Q
R
V
L
F
L
W
R
N
A
D
T
V
V
I
G
R
A
Q
N
P
W
K
E
C
N
T
R
R
M
E
E
D
N
V
R
L
A
R
R
S
S
G
G
G
A
V
F
H
D
L
G
N
T
C
F
T
F
M
A
---
G
K
P
E
Y
D
K
T
I
S
T
S
I
V
L
N
A
L
N
A
L
G
V
S
--
A
E
A
S
G
R
N
D
L
V
V
K
----
T
V
EGDR
K
V
S
G
S
A
Y
R
E
T
K
D
R
G
F
H
H
G
T
L
L
L
N
A
D
L
S
R
L
A
N
Y
L
N
P
D
K
K
K
L
A
A
K
G
------
R
V
T
N
L
T
E
L
L
P
-----
G
I
T
H
E
Q
V
C
E
A
I
T
E
A
F
F
A
H
Y
G
E
R
V
--
E
A
E
I
I
S
P
---
N
K
T
P
D
L
P
N
F
A
E
T
F
A
R
Q
S
S
W
E
W
N
F
G
Q
A
P
A
F
S
H
L
L
D
E
R
F
T
W
G
G
V
E
L
H
F
D
V
E
K
G
H
I
T
R
A
Q
V
F
T
D
S
L
N
-
P
A
P
L
E
A
L
A
G
R
L
Q
G
C
L
Y
R
A
D
M
L
Q
Q
------------------------
25
PsiBlast_CBE
57.52
33%
-20
- C1 -
-
4TVW
1
LPLA_ECOLI
D:
[12-306]
-----
S
D
S
Y
D
P
W
F
N
L
A
V
A
E
C
I
F
R
Q
M
P
A
T
Q
R
V
L
F
L
W
R
N
A
D
T
V
V
I
G
R
A
Q
N
P
W
K
E
C
N
T
R
R
M
E
E
D
N
V
R
L
A
R
R
S
S
G
G
G
A
V
F
H
D
L
G
N
T
C
F
T
F
M
A
---
G
K
P
E
Y
D
K
T
I
S
T
S
I
V
L
N
A
L
N
A
L
G
V
S
--
A
E
A
S
G
R
N
D
L
V
V
K
----
T
V
EGDR
K
V
S
G
S
A
Y
R
E
T
K
D
R
G
A
H
G
G
T
L
L
L
N
A
D
L
S
R
L
A
N
Y
L
N
P
D
K
K
K
L
A
A
K
G
I
T
S
V
R
S
R
V
T
N
L
T
E
L
L
P
G
-----
I
T
H
E
Q
V
C
E
A
I
T
E
A
F
F
A
H
Y
G
E
R
V
--
E
A
E
I
I
S
P
---
N
K
T
P
D
L
P
N
F
A
E
T
F
A
R
QS
S
W
E
W
N
F
G
Q
A
P
A
F
S
H
L
L
D
E
R
F
T
W
G
G
V
E
L
H
F
D
V
E
K
G
H
I
T
R
A
Q
V
F
T
D
S
L
N
-
P
A
P
L
E
A
L
A
G
R
L
Q
G
C
L
Y
-------------------------------
11
PsiBlast_PDB
57.22
33%
-15
- C1 -
-
4TVW
1
LPLA_ECOLI
A:
[12-306]
-----
S
D
S
Y
D
P
W
F
N
L
A
V
A
E
C
I
F
R
Q
M
P
A
T
Q
R
V
L
F
L
W
R
N
A
D
T
V
V
I
G
R
A
Q
N
P
W
K
E
C
N
T
R
R
M
E
E
D
N
V
R
L
A
R
R
S
S
G
G
G
A
V
F
H
D
L
G
N
T
C
F
T
F
M
A
---
G
K
P
E
Y
D
K
T
I
S
T
S
I
V
L
N
A
L
N
A
L
G
V
S
--
A
E
A
S
G
R
N
D
L
V
V
K
----
T
V
EGDR
K
V
S
G
S
A
Y
R
E
T
K
D
R
G
A
H
G
G
T
L
L
L
N
A
D
L
S
R
L
A
N
Y
L
N
P
D
K
K
K
L
A
A
K
G
I
T
S
V
R
S
R
V
T
N
L
T
E
L
L
P
G
-----
I
T
H
E
Q
V
C
E
A
I
T
E
A
F
F
A
H
Y
G
E
R
V
--
E
A
E
I
I
S
P
---
N
K
T
P
D
L
P
N
F
A
E
T
F
A
R
Q
S
S
W
E
W
N
F
G
Q
A
P
A
F
S
H
L
L
D
E
R
F
T
W
G
G
V
E
L
H
F
D
V
E
K
G
H
I
T
R
A
Q
V
F
T
D
S
L
N
-
P
A
P
L
E
A
L
A
G
R
L
Q
G
C
L
Y
-------------------------------
7
PsiBlast_PDB
56.97
34%
-16
- C1 -
-
3A7A
2
LPLA_ECOLI
A:
[8-302]
-----
S
D
S
Y
D
P
W
F
N
L
A
V
E
E
C
I
F
R
Q
M
P
A
T
Q
R
V
L
F
L
W
R
N
A
D
T
V
V
I
G
R
A
Q
N
P
W
K
E
C
N
T
R
R
M
E
E
D
N
V
R
L
A
R
R
S
S
G
G
G
A
V
F
H
D
L
G
N
T
C
F
T
F
M
A
---
G
K
P
E
Y
D
K
T
I
S
T
S
I
V
L
N
A
L
N
A
L
G
V
S
--
A
E
A
S
G
R
N
D
L
V
V
K
----
T
V
EGDR
K
V
S
G
S
A
Y
R
E
T
K
D
R
G
F
H
H
G
T
L
L
L
N
A
D
L
S
R
L
A
N
Y
L
N
P
D
K
K
K
L
A
A
K
G
I
T
S
V
R
S
R
V
T
N
L
T
E
L
L
P
G
-----
I
T
H
E
Q
V
C
E
A
I
T
E
A
F
F
A
H
Y
G
E
R
V
--
E
A
E
I
I
S
P
---
N
K
T
P
D
L
P
N
F
A
E
T
F
A
R
Q
S
S
W
E
W
N
F
G
Q
A
P
A
F
S
H
L
L
D
E
R
F
T
W
G
G
V
E
L
H
F
D
V
E
K
G
H
I
T
R
A
Q
V
F
T
D
S
L
N
-
P
A
P
L
E
A
L
A
G
R
L
Q
G
C
L
Y
-------------------------------
8
PsiBlast_PDB
56.79
34%
-13
- C1 -
-
3A7R
1
LPLA_ECOLI
A:
[8-302]
-----
S
D
S
Y
D
P
W
F
N
L
A
V
E
E
C
I
F
R
Q
M
P
A
T
Q
R
V
L
F
L
W
R
N
A
D
T
V
V
I
G
R
A
Q
N
P
W
K
E
C
N
T
R
R
M
E
E
D
N
V
R
L
A
R
R
S
S
G
G
G
A
V
F
H
D
L
G
N
T
C
F
T
F
M
A
---
G
K
P
E
Y
D
K
T
I
S
T
S
I
V
L
N
A
L
N
A
L
G
V
S
--
A
E
A
S
G
R
N
D
L
V
V
K
----
T
V
E
G
D
R
K
V
S
G
S
A
Y
R
E
T
K
D
R
G
F
H
H
G
T
L
L
L
N
A
D
L
S
R
L
A
N
Y
L
N
P
D
K
K
K
L
A
A
K
G
I
T
S
V
R
S
R
V
T
N
L
T
E
L
L
P
G
-----
I
T
H
E
Q
V
C
E
A
I
T
E
A
F
F
A
H
Y
G
E
R
V
--
E
A
E
I
I
S
P
---
N
K
T
P
D
L
P
N
F
A
E
T
F
A
R
Q
S
S
W
E
W
N
F
G
Q
A
P
A
F
S
H
L
L
D
E
R
F
T
W
G
G
V
E
L
H
F
D
V
E
K
G
H
I
T
R
A
Q
V
F
T
D
S
L
N
-
P
A
P
L
E
A
L
A
G
R
L
Q
G
C
L
Y
-------------------------------
23
PsiBlast_CBE
55.22
34%
-7
- C1 -
-
3A7A
2
LPLA_ECOLI
C:
[8-302]
-----
S
D
S
Y
D
P
W
F
N
L
A
V
E
E
C
I
F
R
Q
M
P
A
T
Q
R
V
L
F
L
W
R
N
A
D
T
V
V
I
G
R
A
Q
N
P
W
K
E
C
N
T
R
R
M
E
E
D
N
V
R
L
A
R
R
S
S
G
G
G
A
V
F
H
D
L
G
N
T
C
F
T
F
M
A
---
G
K
P
E
Y
D
K
T
I
S
T
S
I
V
L
N
A
L
N
A
L
G
V
S
--
A
E
A
S
G
R
N
D
L
V
V
K
----
T
V
EGDR
K
V
S
G
S
A
Y
R
E
T
K
D
R
G
F
H
H
G
T
L
L
L
N
A
D
L
S
R
L
A
N
Y
L
N
P
D
K
K
K
L
A
A
K
G
I
T
S
V
R
S
R
V
T
N
L
T
E
L
L
P
G
-----
I
T
H
E
Q
V
C
E
A
I
T
E
A
F
F
A
H
Y
G
E
R
V
--
E
A
E
I
I
S
P
---
N
K
T
P
D
L
P
N
F
A
E
T
F
A
R
QS
S
W
E
W
N
F
G
Q
A
P
A
F
S
H
L
L
D
E
R
F
T
W
G
G
V
E
L
H
F
D
V
E
K
G
H
I
T
R
A
Q
V
F
T
D
S
L
N
-
P
A
P
L
E
A
L
A
G
R
L
Q
G
C
L
Y
-------------------------------