@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y1P2: (2018-01-26 )
MAHKHKLDSILDFPEASEREDNIIELKTWMSRLRCNKDDQIKSNSVVNAELILTNDSNLAGTIAYNEFSGYIHLLKDSPWINRTAGEWEDSFEDALTAYIEENYNVVFDDNKIHKAVVNVARKNVFNPVKERIEKVKWDQQPRLETLFIDLLGVDDNLYTREVTKRWIVGSVARIYKPGIKFEIVPVLDGPQGIGKSTVPALLYTDDFFTDSLDSLGEKKDDYMQLQGNVIIELGELSSMNKTKIEQIKNFISAKIDKIRPPYGRNVIAWARQCVFIGTSNDGQYLKDDTGNRRFYPLPCKNKPKMNPFKTKDEYFLQVLAEAKVLFDKGQRIYFSPDEDKEVLEIAKDYQEDAKMENPIKEAITKYLEMEIPYKWEEAPAWARRSYYQNYPDSKCNEKNLQHFYNGATMQQEFYLVDSVLTADILEAVFDKQAKDLLNGRSDAETKKIALIISSIPGWERKQLPKRNKRRGFYNKSNAYENKNRAGKYKK
Atome Classification :
(20 SA)
----------------------------------.........10---.......----..20......-..30-------........40........50-----.........60---------.........70--.........-----------------------80........90..---......------100.......110--.........120.-......--130.......-140.-------------......150-.......160-.......170.......180..---...----...190-----------.........200...--.----.--..-----210.-....-----..---220-----.-----------------......-.--.230...---....240-----------------..--......----------.250....--------...---260.-.-------....--.270---.......280.....---------------.----------.--290.......300--....-.....-310.......320.....-----..--330.......340...--....350..--------.-----......--360.....-------------..370-------....---...380--.......-390.......400.----------------.--.....-------------410...---....420..---------.----....430...---....440-........450-........460-------------......----.470----------........480.......490-------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------------------MAH
K
H
K
L
D
S
I
----LDFPEAS----ERED
N
I
I
E
L
K
-
T
W
M
S
-------
R
LRCNKDDQIKSNS
V
V
N
A
E
------
L
I
L
TNDSN
L
A
----------
G
T
I
A
YNEFS
G
---
Y
I
H
L
LKDSP-----------------------WINRTAGEW
E
D
S
F
E
---
D
A
L
T
A
Y
------
I
EEN
Y
N
V
V
FDD----N
K
I
H
K
A
V
V
N
V
A
R
K
-
N
V
F
N
P
V
--
K
E
R
I
E
KVKWD-QQP
R
-------------
L
E
T
L
F
I
D
L
L-GVDDN
L
Y
T
R
E
-
V
T
K
R
W
I
V
G
S
V
A
R
I
YKPGI-
K
F
E
---
I
V
P
----VLDG-------------PQGIGKST
V
P
A
L
L
Y
T--D----D--F
F
-----
T
D
S
L
-
D
S
LG-----EK---K-------D-----------------
D
Y
M
Q
LQ-G--
N
V
I
I
E
LG---ELSSM-------------------
N
K
--
T
K
I
E
Q
I
----------
K
N
F
I
S
A
K
I
--------
D
KI---RPPY-G-------R
N
V
I
--
A
W
AR---
Q
C
V
F
I
G
TSNDGQYLK---------------D----------D--TGN
R
R
F
YPLPC----KNKP-KMNPF-KT
K
D
E
Y
F
L
Q
V
L
A
E
A
K
V
LF-----DK--G
Q
R
I
Y
FSPDE
D
K
E
V
L
E
--
I
A
K
D
Y
--
Q
E
--------
D
-----AKMEN
P
--
I
K
E
A
I
T
K
Y
-------------
L
EMEI-------PYKW---EEA
P
A
W
--
A
R
R
S
Y
Y
Q-NYPDSKC
N
E
K
N
L
Q
H
----------------
F
--YNGA
T
-------------
M
Q
Q
E
F
Y
---
L
V
D
S
V
L
T
A
D
---------
I
----
L
E
A
V
F
D
K
Q
A
K
---
D
L
LNGR--SDAET
K
K
I
A
L
--
I
I
SSIPGW
E
R
K-------------QLPK
R
N
----KRR-----------GFYNKSNAYENKNRAGKYKK--------------------------------------------------------------------------------------------
52
Fugue
55.76
19%
52
* C6 *
-
4OUA
3
?
B:
[4-557]
----------------------------------------
L
L
A
T
----
V
G
P
T
G
G
V
----
K
N
R
L
D
I
V
D
F
-----------------
V
R
D
E
K
F
F
T
L
Y
I
R
A
L
Q
------
A
I
Q
D
K
D
Q
S
D
Y
----------
S
S
--
F
F
Q
L
S
G
----
I
H
G
L
P
F
T
P
-----------------------
W
-
A
K
P
K
D
T
P
T
V
P
Y
E
---
S
G
Y
C
T
H
SQVLFP
T
W
H
R
V
Y
V
S
I
Y
E
----
Q
I
L
Q
E
A
A
K
G
I
A
K
K
---
F
T
V
H
--
K
K
E
W
A
Q
A
A
E
D
L
R
Q
P
Y
-------------
W
D
T
G
F
-
A
L
V
-
P
P
D
E
I
I
K
L
E
Q
-
V
K
I
T
N
Y
D
G
T
K
I
T
V
R
N
P
I
L
-
R
Y
S
FHP
I
D
P
----
S
F
N
G
YPNFDTWKTTVRN
P
D
A
D
K
K
E
N
I
P
A
L
I
G
K
--
L
----
D
--
L
--------
E
A
-
D
S
T
R
-----
E
K
---
T
-------
Y
-----------------
N
M
L
K
F
N
-
A
NW
E
A
F
S
N
H
G
---
E
F
D
D
T
-------------------
H
A
--
N
S
L
E
A
V
----------
H
D
D
I
H
G
F
V
GR------
G
A
I
---
R
G
H
M
-
T
-------
H
A
L
F
--
A
A
F
D
---
P
I
F
W
L
H
H
S
N
V
D
R
H
L
S
LWQALYPGVWVTQGP
E
----------
R
--
E
G
S
M
G
F
A
P
G
T
E
----
L
N
K
D
S
A
L
E
P
F
Y
E
T
E
D
K
P
W
T
S
V
P
L
T
D
T
A
L
L
NYSYP
D
F
--
D
K
V
K
G
G
T
P
D
L
V
R
D
Y
I
N
DH
I
D
R
R
Y
GI
K
K
--------
S
-----
E
G
G
K
N
P
--
A
Q
D
L
L
S
D
F
KGVTHDHNEDLKM
F
D
W
T
I
-------
Q
A
S
W
KKF
E
L
D
D
S
F
--
A
I
I
F
Y
F
A
A
D
G
S
T
N
V
T
K
E
N
Y
I
G
S
----------------
I
NI
F
R
G
T
T
PTNCANCRTQDNL
V
Q
E
G
F
V
---
H
L
D
R
F
I
A
R
D
---------
L
DTFD
P
Q
A
V
H
R
Y
L
K
E
---
K
K
L
S
Y
K
--
V
V
A
D
D
H
S
V
T
L
KS
L
R
I
R
V
Q
G
R
P
L
H
LPPGV--------
S
F
P
R
L
D
----
K
N
I
-----------
P
I
V
N
F
D
D
V
L
D
L
V
T
G
--------------------------------------------------------------------------------------------------
53
Fugue
55.64
18%
30
- C6 -
-
4K70
1
?
A:
[2-483]
------------------PG
S
M
E
A
L
V
R
A
L
E
EADH
A
V
A
T
V
V
Q
S
R
I
----
L
E
F
F
M
A
A
----
G
R
E
T
P
A
G
V
R
G
-
L
W
A
R
-------
A
L
R
L
A
C
R
A
Y
V
E
T
G
T
-
C
E
A
A
------
V
L
A
E
N
L
A
G
L
A
L
W
RLRHDWDE
G
T
A
P
L
L
E
L
L
G
---
V
V
N
G
-
D
D
T
T
-----------------------
A
A
L
T
E
A
G
-
L
R
T
S
A
E
FG
P
D
A
M
F
R
L
------
V
S
E
W
C
A
A
F
D
E
A
----
L
A
G
A
R
S
A
D
D
V
L
A
A
-
P
R
V
V
P
P
--
E
Q
T
A
R
A
L
V
----
Q
P
R
-------------
F
A
T
L
Y
-
D
M
D
-
F
V
Q
D
G
L
R
Y
V
A
-
Q
H
T
N
W
A
L
P
L
A
L
A
V
R
Q
M
Q
N
----------------
E
G
-------------
L
K
P
L
T
R
A
L
F
-
A
L
T
I
A
--
D
----
E
--
F
F
-----
H
D
R
Q
N
P
T
L
R
-----
E
Q
F
--
A
-------
E
-----------------
A
A
R
A
V
D
-
E
--
A
A
L
V
P
V
G
---
E
V
N
A
T
-------------------
P
R
--
T
A
V
E
V
R
----------
V
S
A
A
L
A
H
G
--------
D
------------------------
A
Y
V
R
---
E
------------
L
R
---------------
P
----------
G
--
T
V
A
R
R
L
---------
R
T
D
Q
-
G
V
L
A
L
-
L
D
P
G
A
Q
A
V
H
V
A
A
A
A
D
L
D
H
-----
T
Q
VD
A
T
G
V
W
E
A
V
Q
A
S
A
S
P
L
Q
--
V
V
E
A
L
--
V
T
--------
A
-----
G
-------
F
T
R
R
H
C
D
L
-------------
L
E
R
A
V
-------
L
------
D
R
A
P
R
L
T
D
A
Q
R
A
V
G
C
-
T
A
V
V
G
G
V
V
H
R
L
L
D
D
----------------
Y
--
G
P
G
L
D
-------------
Y
V
R
A
Y
T
---
D
V
A
D
T
L
E
P
L
YGDVTAALG
L
----
P
E
K
G
V
E
H
V
V
R
---
H
C
M
A
P
R
PP
T
E
H
V
G
A
A
R
A
A
--
L
L
R
E
V
A
A
A
E
R
R
-------------
A
G
L
A
H
S
----
A
A
R
-----------
E
A
L
N
T
W
L
A
F
R
A
Q
S
R
W
G
L
-----------------------------------------------------------------------------------------------
50
Fugue
50.69
19%
32
- C3 -
-
4UOX
9
PAT_ECOLI
A:
[7-459]
-----------------------------SAS
A
L
A
C
S
A
H
A
L
N
L
I
E
KRT
L
D
H
E
E
M
K
----
A
L
N
R
E
V
I
E
Y
F
-
K
E
H
-----------------------
V
N
P
G
------
F
L
E
Y
R
K
S
V
T
A
----------
G
---------------------------------------------
G
D
Y
G
A
V
E
W
Q
A
G
S
L
---
N
T
L
V
D
T
------
Q
G
Q
E
F
I
D
C
L
G
G
----
F
G
I
F
--
N
V
G
H
R
N
P
-
V
V
V
S
A
V
--
Q
N
Q
L
A
K
Q
P
L
H
-
S
Q
E
L
-------------
L
D
P
L
R
A
M
L
A
-
K
T
L
A
A
L
T
P
G
K
-
L
K
Y
S
F
F
C
N
S
G
T
E
S
V
E
A
A
L
-
K
-----
L
A
K
----
A
Y
Q
S
-------------
P
R
G
--
K
F
T
F
I
A
T
--
S
--
G
----
A
--
F
H
-----
G
K
S
L
-
G
A
L
S
A
TAKS
T
F
---
R
-------
K
-----------------
P
F
M
P
L
L
P
G
--
F
R
H
V
P
F
G
---
N
I
E
A
M
-------------------
R
T
A
L
N
E
C
K
K
T
----------
G
D
D
V
A
A
V
I
L
E
PIQGEG
G
V
I
---
L
P
P
P
-
G
--------------
Y
L
T
---
A
V
R
K
L
C
D
E
F
G
A
L
M
I
L
---------------
D
----------
E
VQ
T
G
M
G
R
T
G
K
M
F
A
----
C
E
H
E
-
N
V
Q
P
----------
D
I
L
C
L
A
K
A
L
G
-----
G
G
--
V
M
P
I
G
A
T
I
A
T
-
E
E
V
F
S
--
V
L
F
D
N
--
P
F
L
H
T
T
T
FGG
N
-----
P
L
A
C
A
A
--
A
L
A
T
I
N
V
L
-------------
L
E
Q
N
L
-------
P
A
Q
A
---
E
Q
K
G
D
M
--
L
L
D
G
F
R
Q
-
L
A
R
E
Y
P
----
D
L
V
Q
----------------
E
--
A
R
G
K
G
-------------
M
L
M
A
I
E
---
F
V
D
N
E
I
G
Y
N
---------
F
----
A
S
E
M
F
R
Q
R
------
V
L
V
A
G
--
T
L
N
N
A
K
T
I
R
I
--
E
P
P
L
T
L
T
I
E
Q
C
-------------
E
L
V
I
K
A
----
A
R
K
-----------
A
L
A
A
M
R
V
S
V
E
E
A
----------------------------------------------------------------------------------------------------
21
HHSearch
43.14
12%
-75
- C8 -
-
1U0J
1
REP68_AAV2S
A:
[102-230]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
R
---
N
T
I
----
W
L
F
G
-------------
P
A
T
T
G
K
T
N
I
A
E
A
I
-
A
--
H
----
T
--
V
P
-----
F
Y
G
C
-
V
N
W
T
-----
N
E
---
N
-------
F
-----------------
P
F
N
D
C
V
-
D
--
K
M
V
I
W
W
E
---
E
G
K
M
T
-------------------
A
---
K
V
V
E
S
A
----------
K
A
I
L
G
G
S
K
--------
V
R
V
-----------------
S
-
A
--
Q
I
D
P
----
T
P
V
I
V
T
S
N
T
N
M
C
A
V
---------------
I
D
GNSTTFEH
Q
Q
--
P
L
Q
D
R
M
F
K
F
E
L
----
T
R
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
42.98
17%
40
- C1 -
-
5MQ6
3
?
A:
[14-655]
--------------------------------P
E
D
L
K
L
H
Q
L
S
Q
K
----
Y
T
A
E
A
A
K
R
FRP
E
G
L
G
Q
F
I
R
L
K
E
V
G
N
E
-------
R
F
R
A
L
A
E
D
P
W
V
D
H
A
A
L
N
A
K
------
E
P
V
K
D
G
S
R
Y
K
----------
F
I
I
L
G
A
G
Y
G
G
---
L
L
Y
A
V
R
L
A
E
A
GLASGPDD
I
L
M
V
D
AAGGFGG
T
W
W
W
N
R
Y
P
G
L
H
C
D
V
E
S
---
Y
S
Y
M
P
L
------
L
E
E
T
G
Y
I
P
K
S
K
YAA
G
P
E
L
L
E
H
A
Y
R
I
A
T
Q
W
K
L
H
D
K
A
LF
R
S
N
V
K
T
I
R
W
D
-
D
E
S
R
-------------
L
W
S
L
E
V
T
E
G
R
G
P
G
Q
Q
S
R
E
L
K
-
L
Q
A
R
Y
V
L
L
A
S
G
I
L
T
N
P
---------
Q
V
P
----
K
I
P
G
-------------
L
E
T
F
T
G
P
V
F
H
T
A
R
W
N
--
Y
----
D
--
V
T
GGSPT
D
E
A
L
-
N
R
L
E
-----
G
K
---
R
V
G
I
I
G
TG
A
-----------------
T
A
I
Q
V
V
-
P
--
K
L
A
K
Y
A
K
---
E
L
Y
V
F
Q
RTPSG
V
W
W
R
GQRPTD
P
V
E
W
K
--
T
K
I
A
R
K
----------
K
G
W
Q
R
E
R
M
--------
L
N
L
---
D
S
Y
L
-
T
DAAEEGQ
E
N
M
V
AD
G
W
T
E
M
PA
F
S
A
V
I
G
S
P
R
H
G
I
V
E
P
T--------------
P
----------
E
--
K
I
A
E
H
L
G
R
L
Y
K
----
L
D
L
P
-
H
A
E
Q
V
-
R
A
R
T
D
S
I
V
K
D
P
K
T
A
A
K
L
K
AWYP-
T
W
--
C
K
R
P
T
F
S
-
D
E
Y
L
Q
T
F
N
--
L
P
N
V
H
--
L
V
--------
D
TDGKG
V
D
A
A
N
P
S
G
L
V
V
A
D
K
E
Y
P
------------
L
D
I
L
V
L
STGYVT
P
S
I
G
---
G
G
S
P
A
V
--
R
T
G
V
D
I
Y
-
G
R
G
G
K
S
L
D
D
K
W
Q
T
H
G
A
A
T
L
HGVCSNGFPNL
F
--
F
T
P
L
S
-------------
Q
S
S
Q
A
A
N
N
A
F
T
L
D
V
G
T
E
H
---------
I
----
V
Q
V
I
K
T
A
E
D
R
V
D
G
D
A
L
V
E
V
--
T
S
E
A
E
E
A
W
S
F
--
E
I
M
K
H
A
G
W
F
A
S
VTGCTPGYITSEG
E
A
P
M
E
M
----
A
K
R
A
R
S
GNLSQG
M
A
S
Y
M
K
L
L
Q
E
Y
R
A
D
G
S
L
K
G
F
D
I
SSRA----------------------------------------------------------------------------------------
40
HHSearch
41.41
29%
-121
- C8 -
-
3D8B
1
FIGL1_HUMAN
A:
[117-157]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
---
K
G
I
----
L
L
F
G
-------------
P
P
G
T
G
K
T
L
I
G
K
C
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
40.33
41%
-107
- C7 -
-
4AZB
1
A:
[4-51]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
K
K
I
V
S
-----
I
D
--
A
G
R
K
Y
F
S
P
E
Q
L
K
E
I
I
D
--
K
A
K
H
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
39.61
41%
-105
- C7 -
-
2YL8
1
A:
[4-34]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
K
K
I
V
S
-----
I
D
--
A
G
R
K
Y
F
S
P
E
Q
L
K
E
I
I
D
--
K
A
K
H
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
39.39
41%
-94
- C7 -
-
3RPM
1
?
A:
[9-39]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
K
K
I
V
S
-----
I
D
--
A
G
R
K
Y
F
S
P
E
Q
L
K
E
I
I
D
--
K
A
K
H
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
39.35
12%
-48
- C8 -
-
1S9H
-
REP68_AAV2S
A:
[325-453]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
R
---
N
T
I
----
W
L
F
G
-------------
P
A
T
T
G
K
T
N
I
A
E
A
I
-
A
--
H
----
T
--
V
P
-----
F
Y
G
C
-
V
N
W
T
-----
N
E
---
N
-------
F
-----------------
P
F
N
D
C
V
-
D
--
K
M
V
I
W
W
E
---
E
G
K
M
T
-------------------
A
---
K
V
V
E
S
A
----------
K
A
I
L
G
G
S
K
--------
V
R
V
---
D
Q
K
C
-
K
-------
S
S
A
---
Q
I
D
P
----
T
P
V
I
V
T
S
N
T
N
M
C
A
V
I
D
GNSTTFEH-----
Q
----------
Q
--
P
L
Q
D
R
M
F
K
F
E
L
----
T
R
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
38.98
41%
-105
- C7 -
-
4AZ6
2
A:
[6-36]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
K
K
I
V
S
-----
I
D
--
A
G
R
K
Y
F
S
P
E
Q
L
K
E
I
I
D
--
K
A
K
H
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
38.97
41%
-107
- C7 -
-
2YLL
1
A:
[24-54]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
K
K
I
V
S
-----
I
D
--
A
G
R
K
Y
F
S
P
E
Q
L
K
E
I
I
D
--
K
A
K
H
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
38.92
14%
32
- C4 -
-
4Z24
1
YR135_MIMIV
A:
[4-652]
NLTGD
I
V
I
I
G
AG
A
A
G
S
L
L
A
H
Y
L
A
R
F
S
N
M
K
I
I
L
L
E
A
G
H
S
H
F
N
D
P
V
----
V
T
D
P
M
G
F
----
F
G
K
Y
N
P
P
N
E
N
-
I
S
M
S
QNPSYSW
Q
G
A
Q
E
P
N
T
G
A
Y
G
N
R
P
I
I
A
H
G
MGFGG
S
T
M
I
N
R
L
N
L
V
VGG-------
R
T
V
F
D
N
D
W
P
V
GWK
Y
D
D
V
K
N
Y
F
R
-----------------------
R
V
L
V
D
I
N
P
V
R
D
N
T
K
---
A
S
I
T
S
V
------
A
L
D
A
L
R
I
I
A
E
Q
----
Q
I
A
S
G
E
P
V
D
F
L
L
N
-
K
A
T
G
N
V
--
P
-
N
V
E
K
T
T
P
D
-
A
V
P
L
N
LNDYEGVNS
V
V
A
F
S
S
F
Y
M
G
V
N
-
Q
L
S
D
G
N
Y
I
R
K
Y
A
G
N
T
Y
L
N
R
N
Y
V
D
E
N
G
R
G
I
G
K
F
S
---
G
L
R
----
V
V
S
D
-------------------
A
V
V
D
R
I
I
F
K
--
G
----
N
--
R
A
-----
V
G
V
N
-
Y
I
D
R
-----
E
G
---
I
-------
M
-----------------
H
Y
V
K
V
N
-
K
--
E
V
V
V
T
S
G
AFY
T
P
T
I
L
-------------------
Q
R
--
S
G
I
G
D
F
----------
T
Y
L
S
S
I
G
V
--------
K
N
L
VYN
N
P
L
V
-
G
-------
T
G
L
K
--
N
H
Y
S
---
P
V
T
I
T
R
V
H
G
E
P
S
E
V
S
---------------
R
F
L
SNMAANPT
N
--
M
G
F
K
G
L
A
E
L
G
F
HRLD
P
N
K
P
-
A
N
A
N
T
-
V
T
Y
R
K
Y
Q
L
M
M
T
A
G
V
G
I
P
A
-----
E
Q
--
Q
Y
L
S
G
L
S
P
S
S
N
N
L
F
T
L
--
I
A
D
D
---------------------------
I
R
F
A
P
E
G
Y
-------------
I
K
I
G
T
-------
P
N
I
P
---
R
D
V
P
K
I
--
F
F
N
T
F
V
T
-
Y
T
P
T
S
A
P
A
D
Q
Q
W
P
I
----------------
A
--
Q
K
T
L
------------------
A
P
---
L
I
S
A
L
L
G
Y
D
---------
I
----
I
Y
Q
T
L
M
S
M
N
Q
---
T
A
R
D
S
G
--
F
Q
V
S
L
E
M
V
Y
P
--
L
N
D
L
I
Y
K
L
H
N
G
-------------
L
A
T
Y
G
A
----
N
W
W
-----------
H
Y
F
V
P
T
L
V
G
D
D
T
P
A
G
R
E
F
A
D
T
L
S
K
L
S
Y
Y
P
R
VG
A
H
L
D
SHQGCSCSIGRTVDSNLKVIGTQ
N
V
R
V
A
D
LSAAAFPPGGNT
W
A
T
A
S
M
I
G
A
R
A
V
D
L
I
L
GFPYLRDLPVND
V
P
I
L
N
VN
10
PsiBlast_PDB
38.47
41%
-99
- C7 -
-
2YL6
1
A:
[4-34]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
K
K
I
V
S
-----
I
D
--
A
G
R
K
Y
F
S
P
E
Q
L
K
E
I
I
D
--
K
A
K
H
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
38.34
14%
62
- C2 -
-
5UDB
2
ORC3_YEAST
C:
[52-614]
----------------------------V
N
V
E
K
R
W
E
L
Y
H
Q
L
H
S
H
----
F
H
D
Q
V
D
H
----
I
I
D
N
I
E
A
D
L
K
-
A
E
I
S
-------
D
L
L
--
Y
S
E
T
T
Q
K
R
R
C
F
N
T
I
------
F
L
L
G
S
D
S
T
T
K
----------
I
E
L
-
K
D
E
S
S
R
---
Y
N
V
L
I
E
L
T
P
-----------------------
K
E
S
P
N
V
R
M
M
L
R
R
S
M
---
Y
K
L
Y
S
A
------
A
D
A
E
E
H
V
S
Y
D
L
----
S
L
V
E
N
F
K
R
L
F
G
K
D
-
L
---
A
M
--
V
F
N
F
K
D
V
D
S
I
-
N
F
N
T
-------------
L
D
N
F
I
I
L
L
K
-
S
A
F
K
Y
D
H
V
K
I
-
S
L
I
F
N
I
N
T
N
L
S
N
I
E
K
N
L
R
-
Q
S
T
---
I
R
L
----
L
K
R
N
-------------
Y
H
K
L
D
V
S
S
N
K
G
F
K
Y
G
--
N
----
Q
--
I
F
-----
Q
S
F
L
-
D
T
V
D
-----
G
K
---
L
-------
N
-----------------
L
S
D
R
F
V
-
E
--
F
I
L
S
K
M
A
---
N
N
T
N
H
-------------------
N
L
--
Q
L
L
T
K
M
L
D
Y
S
L
MSYFF
Q
N
A
F
S
V
F
I
--------
D
P
V
---
N
V
D
F
L
N
-------
D
D
Y
L
--
K
I
L
S
---
R
C
P
T
F
M
F
F
V
E
G
L
I
K
Q
---------------
H
----------
A
--
P
A
D
E
I
L
S
L
L
T
N
----
K
N
---------
R
G
L
E
E
F
F
V
E
F
L
V
R
E
N
P
I
N
-----
G
H
--
A
K
F
V
A
R
F
L
E
E
E
L
N
I
------
T
N
F
--
N
L
--------
I
-----
E
L
Y
H
N
L
--
L
I
G
K
L
D
S
Y
-------------
L
D
------------
R
W
---
S
A
C
K
E
Y
--
K
D
R
L
H
F
E
---
P
I
D
T
I
F
D
N
L
L
S
W
----------------
E
--
Q
V
L
P
S
-------------
L
D
K
E
N
Y
-----
D
T
L
S
G
A
P
---------
V
----
L
G
Q
L
F
K
L
Y
R
E
---
A
--
N
M
T
--
I
N
I
Y
D
F
Y
I
A
F
--
R
-
E
T
L
P
K
E
E
I
L
-------------
N
F
I
R
K
D
P
SNT
K
L
L
-----------
E
L
A
E
T
P
D
A
F
D
K
V
A
L
I
L
F
M
Q
A
I
F
A
F
E
N
M
GLIKFQSTKSYDLVEKCVWR-----------------------------------------------------------------
15
PsiBlast_PDB
38.27
41%
-100
- C7 -
-
4AZ7
1
A:
[4-34]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
K
K
I
V
S
-----
I
D
--
A
G
R
K
Y
F
S
P
E
Q
L
K
E
I
I
D
--
K
A
K
H
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
37.73
41%
-88
- C7 -
-
4AZ5
2
A:
[4-34]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
K
K
I
V
S
-----
I
D
--
A
G
R
K
Y
F
S
P
E
Q
L
K
E
I
I
D
--
K
A
K
H
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
37.63
15%
31
- C8 -
-
2VII
1
PSPF_ECOLI
A:
[29-151]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---
K
P
V
----
L
I
I
G
-------------
E
R
G
T
G
K
E
L
I
A
S
R
L
H
Y
--
L
SSRW
Q
G
P
F
I
-----
S
L
N
C
-
A
A
L
N
-----
E
N
L
L
D
S
-------
E
L
FGHEAQK
R
H
P
------
G
R
F
E
R
A
-
D
--
G
G
T
L
F
L
D
---
E
L
A
T
A
-------------------
P
M
--
M
V
Q
E
K
L
----------
L
R
V
I
E
Y
G
E
--------
L
E
R
---
V
----
G
--------
G
S
Q
--
P
L
Q
V
---
N
V
R
L
V
C
A
T
N
A
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
37.14
15%
20
- C8 -
-
4BS1
1
?
B:
[25-146]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
P
V
----
L
I
T
G
-------------
E
S
G
V
G
K
E
V
V
A
R
L
I
H
K
L
S
D
RS--
K
E
P
F
V
-----
A
L
N
V
-
A
S
I
P
-----
R
D
IFE
A
-------
E
L
F
G
Y
E
K
GAFTGAVSSKE
G
F
F
E
L
A
-
D
--
G
G
T
L
F
L
D
---
E
I
G
E
L
-------------------
S
L
--
E
A
Q
A
K
L
----------
L
R
V
I
E
S
G
K
--------
F
Y
-------
R
-
L
-------
G
G
R
K
--
E
I
E
V
---
N
V
R
I
L
A
A
T
N
R
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
36.57
34%
-86
- C8 -
-
4F4C
-
PGP1_CAEEL
A:
[1097-1147]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
-
S
F
S
---
V
E
P
G
Q
T
L
A
L
V
G
-------------
P
S
G
C
G
K
S
T
V
V
A
L
L
----
E
----
R
--
F
Y
----------
D
T
L
G
-------------------------------------------
G
--
E
I
F
I
D
G
S
---
E
I
K
T
L
-------------------
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------