@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y1X5: (2018-01-28 )
MRAISIKHPGSVDVLEQIEVPVPKPKQGELLIKVHTAAVNRTDIMKRESVSLKPPYPILGVEVAGEVVENKSDISTFTPGTKVYGLVNLGGYAEYAVMPADRAILLPDTLDYVSAAGISEVFLTAYQTLYWLGKLQEGETVLIHAGASGVGTAAIQLARQLSHAKIIVTAGSEEKLAFCKELGADELINYKKQDFQEEVRKITEGRGVDVILDFIGASYWEKNLASIAVDGRWVLIGMLGGTIVPEIDLGVLIGKRVQLLGTLLTPRSDQYKAELAQTFMQKAGPFLENGKIRPIIDRTFQFSAVKQAHEYMEANKNIGKIILKITE
Atome Classification :
(20 SA)
......--...10.-....-...-20........30........40.......-----.50---------------..---.-----------..---..-.-.-60........-70....----....80...---------------...-----------------------------.---------------------------.------------90........100.......110.......120.......130-.--.......140.......150.......160.......170.......180.......190.--...------------------..-----------------------.200........210.......220.......230.......240.......250.----...-...260........270.......280...-..-..-290...--......300.......310.....-.-..320.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
R
A
I
SI--KHPGS
V
-
D
V
L
E
-
Q
IE-VPVPKPKQ
G
E
L
L
I
K
V
H
TAAV
N
R
T
D
I
M
KRE-----SV----------------SL---K-----------PP---Y
P
-
I
-
L
-
G
V
E
V
A
G
E
V
VE-NKSDIS----TFTPG
T
K
V
Y
---------------
G
L
V
-----------------------------N---------------------------L------------GGY
A
E
Y
A
VMPAD
R
A
I
LLPD
T
L
D
Y
V
S
AA
G
I
S
E
V
F
L
T
A
Y
Q
T
L
Y
W
--
L
--GKLQEG
E
T
V
L
I
HAGASG
V
G
T
A
A
I
Q
L
A
R
QLSH
A
K
I
I
V
TAGS
E
E
K
L
A
F
C
K
ELG
A
D
E
L
I
N
Y
K
K
Q
--
D
F
Q
------------------
E
E
-----------------------
V
R
K
-
I
TEGRG
V
D
V
I
L
D
F
I
G
A
S
Y
W
E
K
N
L
A
S
I
A
VDG
R
W
V
L
I
G
MLGGTIVPEI
D
L
G
V
L
I
----
G
K
R
-
V
Q
L
L
G
-
T
LLTPRS
D
Q
Y
K
A
E
L
A
Q
T
F
M
Q
KAGP-FL-EN-G--KIR--
P
I
I
DRT
F
Q
F
S
A
V
K
Q
A
H
E
-
Y
M
E
ANK-N-
I
G
K
I
I
L
K
ITE
23
PsiBlast_CBE
85.45
42%
-25
- C1 -
-
2OBY
1
QORX_HUMAN
C:
[7-338]
M
L
A
V
H
F
--
D
K
P
G
G
P
-
E
N
L
Y
-
V
K
E
-
V
A
K
P
S
P
G
E
G
E
V
L
L
K
V
A
A
S
A
L
N
R
A
D
L
M
Q
R
Q
-----
G
Q
----------------
Y
D
---
P
-----------
P
P
GA-
S
N
-
I
-
L
-
G
L
E
A
S
G
H
V
A
E
L
G
P
G
C
Q
G
----
H
W
K
I
G
D
T
A
M
---------------
A
L
L
-----------------------------
P
---------------------------
G
------------
G
G
Q
A
Q
Y
V
T
V
P
E
G
L
L
M
P
I
P
E
G
L
T
L
T
Q
A
A
A
I
P
E
A
W
L
T
A
F
Q
L
L
H
L
--
V
--
G
N
V
Q
A
G
D
Y
V
L
I
H
A
G
L
S
G
V
G
T
A
A
I
Q
L
T
R
-
M
A
G
A
I
P
L
V
T
A
G
S
Q
K
K
L
Q
M
A
E
K
L
G
A
A
A
G
F
N
Y
K
K
E
--
D
F
S
------------------
E
A
-----------------------
T
L
K
-
F
T
K
G
A
G
V
N
L
I
L
D
C
I
G
G
S
Y
W
E
K
N
V
N
C
L
A
L
D
G
R
W
V
L
Y
G
L
M
G
G
G
D
I
N
G
P
L
F
S
K
L
L
----
F
K
R
-
G
S
L
I
T
-
S
L
L
R
S
R
D
N
K
Y
K
Q
M
L
V
N
A
F
T
E
Q
I
L
P
H
F
S
-
T
E
-
G
--
P
Q
R
LL
P
V
L
D
R
I
Y
P
V
T
E
I
Q
E
A
H
K
-
Y
M
E
A
N
K
-
N
-
I
G
K
I
V
L
E
L
P
Q
22
PsiBlast_CBE
83.92
42%
-24
- C1 -
-
2OBY
1
QORX_HUMAN
D:
[7-338]
M
L
A
V
H
F
--
D
K
P
G
G
P
-
E
N
L
Y
-
V
K
E
-
V
A
K
P
S
P
G
E
G
E
V
L
L
K
V
A
A
S
A
L
N
R
A
D
L
M
Q
R
Q
-----
G
Q
----------------
Y
D
---
P
-----------
P
P
GA-
S
N
-
I
-
L
-
G
L
E
A
S
G
H
V
A
E
L
G
P
G
C
Q
G
----
H
W
K
I
G
D
T
A
M
---------------
A
L
L
-----------------------------
P
---------------------------
G
------------
G
G
Q
A
Q
Y
V
T
V
P
E
G
L
L
M
P
I
P
E
G
L
T
L
T
Q
A
A
A
I
P
E
A
W
L
T
A
F
Q
L
L
H
L
--
V
--
G
N
V
Q
A
G
D
Y
V
L
I
H
A
G
L
S
G
V
G
T
A
A
I
Q
L
T
R
-
M
A
G
A
I
P
L
V
T
A
G
S
Q
K
K
L
Q
M
A
E
K
L
G
A
A
A
G
F
N
Y
K
K
E
--
D
F
S
------------------
E
A
-----------------------
T
L
K
-
F
T
K
G
A
G
V
N
L
I
L
D
C
I
G
G
S
Y
W
E
K
N
V
N
C
L
A
L
D
G
R
W
V
L
Y
G
L
M
G
G
G
D
I
N
G
P
L
F
S
K
L
L
----
F
K
R
-
G
S
L
I
T
-
S
L
L
R
S
R
D
N
K
Y
K
Q
M
L
V
N
A
F
T
E
Q
I
L
P
H
F
S
-
T
E
-
G
--
P
Q
R
LL
P
V
L
D
R
I
Y
P
V
T
E
I
Q
E
A
H
K
-
Y
M
E
A
N
K
-
N
-
I
G
K
I
V
L
E
L
P
Q
2
PsiBlast_PDB
83.54
42%
-24
- C1 -
-
2OBY
1
QORX_HUMAN
A:
[7-338]
M
L
A
V
H
F
--
D
K
P
G
G
P
-
E
N
L
Y
-
V
K
E
-
V
A
K
P
S
P
G
E
G
E
V
L
L
K
V
A
A
S
A
L
N
R
A
D
L
M
Q
R
Q
-----
G
Q
----------------
Y
D
---
P
-----------
P
P
GA-
S
N
-
I
-
L
-
G
L
E
A
S
G
H
V
A
E
L
G
P
G
C
Q
G
----
H
W
K
I
G
D
T
A
M
---------------
A
L
L
-----------------------------
P
---------------------------
G
------------
G
G
Q
A
Q
Y
V
T
V
P
E
G
L
L
M
P
I
P
E
G
L
T
L
T
Q
A
A
A
I
P
E
A
W
L
T
A
F
Q
L
L
H
L
--
V
--
G
N
V
Q
A
G
D
Y
V
L
I
H
A
G
L
S
G
V
G
T
A
A
I
Q
L
T
R
-
M
A
G
A
I
P
L
V
T
A
G
S
Q
K
K
L
Q
M
A
E
K
L
G
A
A
A
G
F
N
Y
K
K
E
--
D
F
S
------------------
E
A
-----------------------
T
L
K
-
F
T
K
G
A
G
V
N
L
I
L
D
C
I
G
G
S
Y
W
E
K
N
V
N
C
L
A
L
D
G
R
W
V
L
Y
G
L
M
G
G
G
D
I
N
G
P
L
F
S
K
L
L
----
F
K
R
-
G
S
L
I
T
-
S
L
L
R
S
R
D
N
K
Y
K
Q
M
L
V
N
A
F
T
E
Q
I
L
P
H
F
S
-
T
E
-
G
--
P
Q
R
L
L
P
V
L
D
R
I
Y
P
V
T
E
I
Q
E
A
H
K
-
Y
M
E
A
N
K
-
N
-
I
G
K
I
V
L
E
L
P
Q
75
HHSearch
83.40
42%
-27
- C1 -
-
2OBY
1
QORX_HUMAN
E:
[7-337]
M
L
A
V
H
F
--
D
K
P
G
G
P
-
E
N
L
Y
-
V
K
E
-
V
A
K
P
S
P
G
E
G
E
V
L
L
K
V
A
A
S
A
L
N
R
A
D
L
M
Q
R
Q
-----
G
Q
----------------
Y
D
---
P
PP---------
G
A
---
S
N
-
I
-
L
-
G
L
E
A
S
G
H
V
A
E
-
L
G
P
G
C
Q
G---
H
W
K
I
G
D
T
A
M
---------------
A
L
L
-----------------------------
P
---------------------------
G
------------
G
G
Q
A
Q
Y
V
T
V
P
E
G
L
L
M
P
I
P
E
G
L
T
L
T
Q
A
A
A
I
P
E
A
W
L
T
A
F
Q
L
L
H
L
--
V
--
G
N
V
Q
A
G
D
Y
V
L
I
H
A
G
L
S
G
V
G
T
A
A
I
Q
L
T
R
M
A
G
A
-
I
P
L
V
T
A
G
S
Q
K
K
L
Q
M
A
E
K
L
G
A
A
A
G
F
N
Y
K
K
E
--
D
F
S
------------------
E
A
-----------------------
T
L
K
-
F
T
K
G
A
G
V
N
L
I
L
D
C
I
G
G
S
Y
W
E
K
N
V
N
C
L
A
L
D
G
R
W
V
L
Y
G
L
M
G
G
G
D
I
N
G
P
L
F
S
K
L
L
----
F
K
R
-
G
S
L
I
T
-
S
L
L
R
S
R
D
N
K
Y
K
Q
M
L
V
N
A
F
T
E
Q
I
L
P
-
H
F
-
S
T
E
G
PQ
R
L
L
--
P
V
L
D
R
I
Y
P
V
T
E
I
Q
E
A
H
K
-
Y
M
E
A
N
K
-
N
-
I
G
K
I
V
L
E
L
P
-
21
PsiBlast_CBE
82.82
42%
-24
- C1 -
-
2OBY
1
QORX_HUMAN
E:
[7-338]
M
L
A
V
H
F
--
D
K
P
G
G
P
-
E
N
L
Y
-
V
K
E
-
V
A
K
P
S
P
G
E
G
E
V
L
L
K
V
A
A
S
A
L
N
R
A
D
L
M
Q
R
Q
-----
G
Q
----------------
Y
D
---
P
-----------
P
P
GA-
S
N
-
I
-
L
-
G
L
E
A
S
G
H
V
A
E
L
G
P
G
C
Q
G
----
H
W
K
I
G
D
T
A
M
---------------
A
L
L
-----------------------------
P
---------------------------
G
------------
G
G
Q
A
Q
Y
V
T
V
P
E
G
L
L
M
P
I
P
E
G
L
T
L
T
Q
A
A
A
I
P
E
A
W
L
T
A
F
Q
L
L
H
L
--
V
--
G
N
V
Q
A
G
D
Y
V
L
I
H
A
G
L
S
G
V
G
T
A
A
I
Q
L
T
R
-
M
A
G
A
I
P
L
V
T
A
G
S
Q
K
K
L
Q
M
A
E
K
L
G
A
A
A
G
F
N
Y
K
K
E
--
D
F
S
------------------
E
A
-----------------------
T
L
K
-
F
T
K
G
A
G
V
N
L
I
L
D
C
I
G
G
S
Y
W
E
K
N
V
N
C
L
A
L
D
G
R
W
V
L
Y
G
L
M
G
G
G
D
I
N
G
P
L
F
S
K
L
L
----
F
K
R
-
G
S
L
I
T
-
S
L
L
R
S
R
D
N
K
Y
K
Q
M
L
V
N
A
F
T
E
Q
I
L
P
H
F
S
-
T
E
-
G
--
P
Q
R
LL
P
V
L
D
R
I
Y
P
V
T
E
I
Q
E
A
H
K
-
Y
M
E
A
N
K
-
N
-
I
G
K
I
V
L
E
L
P
Q
24
PsiBlast_CBE
81.17
42%
-28
- C1 -
-
2OBY
1
QORX_HUMAN
B:
[7-338]
M
L
A
V
H
F
--
D
K
P
G
G
P
-
E
N
L
Y
-
V
K
E
-
V
A
K
P
S
P
G
E
G
E
V
L
L
K
V
A
A
S
A
L
N
R
A
D
L
M
Q
R
Q
-----
G
Q
----------------
Y
D
---
P
-----------
P
P
GA-
S
N
-
I
-
L
-
G
L
E
A
S
G
H
V
A
E
L
G
P
G
C
Q
G
----
H
W
K
I
G
D
T
A
M
---------------
A
L
L
-----------------------------
P
---------------------------
G
------------
G
G
Q
A
Q
Y
V
T
V
P
E
G
L
L
M
P
I
P
E
G
L
T
L
T
Q
A
A
A
I
P
E
A
W
L
T
A
F
Q
L
L
H
L
--
V
--
G
N
V
Q
A
G
D
Y
V
L
I
H
A
G
L
S
G
V
G
T
A
A
I
Q
L
T
R
-
M
A
G
A
I
P
L
V
T
A
G
S
Q
K
K
L
Q
M
A
E
K
L
G
A
A
A
G
F
N
Y
K
K
E
--
D
F
S
------------------
E
A
-----------------------
T
L
K
-
F
T
K
G
A
G
V
N
L
I
L
D
C
I
G
G
S
Y
W
E
K
N
V
N
C
L
A
L
D
G
R
W
V
L
Y
G
L
M
G
G
G
D
I
N
G
P
L
F
S
K
L
L
----
F
K
R
-
G
S
L
I
T
-
S
L
L
R
S
R
D
N
K
Y
K
Q
M
L
V
N
A
F
T
E
Q
I
L
P
H
F
S
-
T
E
-
G
--
P
Q
R
LL
P
V
L
D
R
I
Y
P
V
T
E
I
Q
E
A
H
K
-
Y
M
E
A
N
K
-
N
-
I
G
K
I
V
L
E
L
P
Q
3
PsiBlast_PDB
80.77
39%
-36
- C1 -
-
4DUP
-
?
A:
[8-331]
-
R
F
V
D
L
--
K
S
F
G
G
P
-
D
V
M
V
-
I
G
K
-
R
P
L
P
V
A
G
E
G
E
V
L
V
R
A
E
A
I
G
V
N
R
P
D
I
A
Q
R
Q
-----
G
-----------------
S
Y
---
P
-----------
P
P
KDA
S
P
-
I
-
L
-
G
L
E
L
S
G
E
I
V
G
-
V
G
P
G
V
S
----
G
Y
A
V
G
D
K
V
C
---------------
G
L
A
-----------------------------
N
---------------------------
G
------------
G
A
Y
A
E
Y
C
L
L
P
A
G
Q
I
L
P
F
P
K
G
Y
D
A
V
K
A
A
A
L
P
E
T
F
F
T
V
W
A
N
L
F
Q
--
M
--
A
G
L
T
E
G
E
S
V
L
I
H
G
G
T
S
G
I
G
T
T
A
I
Q
L
A
R
A
F
G
-
A
E
V
Y
A
T
A
G
S
T
G
K
C
E
A
C
E
R
L
G
A
K
R
G
I
N
Y
R
S
E
--
D
F
A
------------------
A
V
-----------------------
I
K
A
-
E
T
-
G
Q
G
V
D
I
I
L
D
M
I
G
A
A
Y
F
E
R
N
I
A
S
L
A
K
D
G
C
L
S
I
I
A
F
L
G
G
A
V
A
E
K
V
N
L
S
P
I
M
----
V
K
R
-
L
T
V
T
G
-
S
T
M
R
P
R
T
A
E
E
K
R
A
I
R
D
D
L
L
S
E
V
W
P
-
L
L
-
E
A
-
G
--
T
V
A
--
P
V
I
H
K
V
F
A
F
E
D
V
A
D
A
H
R
-
L
L
E
E
G
S
-
H
-
V
G
K
V
M
L
T
V
--
78
HHSearch
79.67
42%
-28
- C1 -
-
2J8Z
1
QORX_HUMAN
A:
[24-353]
-
L
A
V
H
F
--
D
K
P
G
G
P
-
E
N
L
Y
-
V
K
E
-
V
A
K
P
S
P
G
E
G
E
V
L
L
K
V
A
A
S
A
L
N
R
A
D
L
M
Q
R
Q
-----
G
Q
----------------
Y
D
---
P
PP---------
G
A
---
S
N
-
I
-
L
-
G
L
E
A
S
G
H
V
A
E
-
L
G
P
G
C
Q
----
H
W
K
I
G
D
T
A
M
---------------
A
L
L
-----------------------------
P
---------------------------
G
------------
G
G
Q
A
Q
Y
V
T
V
P
E
G
L
L
M
P
I
P
E
G
L
T
L
T
Q
A
A
A
I
P
E
A
W
L
T
A
F
Q
L
L
H
L
--
V
--
G
N
V
Q
A
G
D
Y
V
L
I
H
A
G
L
S
G
V
G
T
A
A
I
Q
L
T
R
M
A
G
A
-
I
P
L
V
T
A
G
S
Q
K
K
L
Q
M
A
E
K
L
G
A
A
A
G
F
N
Y
K
K
E
--
D
F
S
------------------
E
A
-----------------------
T
L
K
-
F
T
K
G
A
G
V
N
L
I
L
D
C
I
G
G
S
Y
W
E
K
N
V
N
C
L
A
L
D
G
R
W
V
L
Y
G
L
M
G
G
G
D
I
N
G
P
L
F
S
K
L
L
----
F
K
R
-
G
S
L
I
T
-
S
L
L
R
S
R
D
N
K
Y
K
Q
M
L
V
N
A
F
T
E
Q
I
L
P
-
H
F
S
T
---Q-
R
L
L
--
P
V
L
D
R
I
Y
P
V
T
E
I
Q
E
A
H
K
-
Y
M
E
A
N
K
-
N
-
I
G
K
I
V
L
E
L
P
-
1
PsiBlast_PDB
79.51
42%
-25
- C1 -
-
2J8Z
1
QORX_HUMAN
A:
[23-354]
M
L
A
V
H
F
--
D
K
P
G
G
P
-
E
N
L
Y
-
V
K
E
-
V
A
K
P
S
P
G
E
G
E
V
L
L
K
V
A
A
S
A
L
N
R
A
D
L
M
Q
R
Q
-----
G
Q
----------------
Y
D
---
P
-----------
P
P
GA-
S
N
-
I
-
L
-
G
L
E
A
S
G
H
V
A
E
L
G
P
G
C
Q
-----
H
W
K
I
G
D
T
A
M
---------------
A
L
L
-----------------------------
P
---------------------------
G
------------
G
G
Q
A
Q
Y
V
T
V
P
E
G
L
L
M
P
I
P
E
G
L
T
L
T
Q
A
A
A
I
P
E
A
W
L
T
A
F
Q
L
L
H
L
--
V
--
G
N
V
Q
A
G
D
Y
V
L
I
H
A
G
L
S
G
V
G
T
A
A
I
Q
L
T
R
-
M
A
G
A
I
P
L
V
T
A
G
S
Q
K
K
L
Q
M
A
E
K
L
G
A
A
A
G
F
N
Y
K
K
E
--
D
F
S
------------------
E
A
-----------------------
T
L
K
-
F
T
K
G
A
G
V
N
L
I
L
D
C
I
G
G
S
Y
W
E
K
N
V
N
C
L
A
L
D
G
R
W
V
L
Y
G
L
M
G
G
G
D
I
N
G
P
L
F
S
K
L
L
----
F
K
R
-
G
S
L
I
T
-
S
L
L
R
S
R
D
N
K
Y
K
Q
M
L
V
N
A
F
T
E
Q
I
L
P
H
F
S
-
T
------
Q
R
LL
P
V
L
D
R
I
Y
P
V
T
E
I
Q
E
A
H
K
-
Y
M
E
A
N
K
-
N
-
I
G
K
I
V
L
E
L
P
Q
64
HHSearch
75.14
39%
-35
* C1 *
-
4DUP
-
?
A:
[7-331]
M
R
F
V
D
L
--
K
S
F
G
G
P
-
D
V
M
V
-
I
G
K
-
R
P
L
P
V
A
G
E
G
E
V
L
V
R
A
E
A
I
G
V
N
R
P
D
I
A
Q
R
Q
-----
G
S
----------------
Y
P
---
P
PK---------
D
A
---
S
P
-
I
-
L
-
G
L
E
L
S
G
E
I
V
G
-
V
G
P
G
V
S
----
G
Y
A
V
G
D
K
V
C
---------------
G
L
A
-----------------------------
N
---------------------------
G
------------
G
A
Y
A
E
Y
C
L
L
P
A
G
Q
I
L
P
F
P
K
G
Y
D
A
V
K
A
A
A
L
P
E
T
F
F
T
V
W
A
N
L
F
Q
--
M
--
A
G
L
T
E
G
E
S
V
L
I
H
G
G
T
S
G
I
G
T
T
A
I
Q
L
A
R
A
F
G
A
-
E
V
Y
A
T
A
G
S
T
G
K
C
E
A
C
E
R
L
G
A
K
R
G
I
N
Y
R
S
E
--
D
F
A
------------------
A
V
-----------------------
I
K
A
-
E
T
-
G
Q
G
V
D
I
I
L
D
M
I
G
A
A
Y
F
E
R
N
I
A
S
L
A
K
D
G
C
L
S
I
I
A
F
L
G
G
A
V
A
E
K
V
N
L
S
P
I
M
----
V
K
R
-
L
T
V
T
G
-
S
T
M
R
P
R
T
A
E
E
K
R
A
I
R
D
D
L
L
S
E
V
W
P
-
L
L
-
E
A
-
G
--
T
V
A
--
P
V
I
H
K
V
F
A
F
E
D
V
A
D
A
H
R
-
L
L
E
E
G
S
-
H
-
V
G
K
V
M
L
T
V
--
4
PsiBlast_PDB
69.75
31%
4
- C1 -
-
2EIH
-
?
A:
[1-342]
M
R
A
V
V
M
--
R
A
R
G
G
P
-
E
V
L
E
-
V
A
D
-
L
P
V
P
E
P
G
P
K
E
V
R
V
R
L
K
A
A
A
L
N
H
L
D
V
W
V
R
K
-----
G
V
A---------------
S
P
---
K
-----------
L
P
---
L
P
H
V
-
L
-
G
A
D
G
S
G
V
V
D
A
-
V
G
P
G
V
E
----
G
F
A
P
G
D
E
V
V
I
NPGLSCGRC
E
R
C
L
A
G
E
D
-----------------------------
N
---------------------------
L
CPRYQILGEHRH
G
T
Y
A
E
Y
V
V
L
P
E
A
N
L
A
P
K
P
K
N
L
S
F
E
E
A
A
A
I
P
L
T
F
L
T
A
W
Q
M
V
V
D
--
K
--
L
G
V
R
P
G
D
D
V
L
V
M
A
A
G
S
G
V
S
V
A
A
I
Q
I
A
K
-
L
F
G
A
R
V
I
A
T
A
G
S
E
D
K
L
R
R
A
K
A
L
G
A
D
E
T
V
N
Y
T
H
P
--
D
W
P
------------------
K
E
-----------------------
V
R
R
-
L
T
G
G
K
G
A
D
K
V
V
D
H
T
G
A
L
Y
F
E
G
V
I
K
A
T
A
N
G
G
R
I
A
I
A
G
A
S
S
G
-
Y
E
G
T
L
P
F
A
H
V
F
----
Y
R
Q
-
L
S
I
L
G
-
S
T
M
A
S
K
S
R
L
F
------
P
I
L
R
-----
F
V
-
E
E
-
G
--
K
L
K
--
P
V
V
G
Q
V
L
P
L
E
A
A
A
E
G
H
R
-
L
L
E
E
R
R
-
V
-
F
G
K
V
V
L
Q
V
--
8
PsiBlast_PDB
68.83
31%
-2
- C1 -
-
3TQH
1
?
A:
[8-320]
-
K
A
I
Q
F
--
D
Q
F
G
P
P
-
K
V
L
K
-
L
V
D
-
T
P
T
P
E
Y
R
K
N
Q
M
L
I
K
V
H
A
A
S
L
N
P
I
D
Y
K
T
R
N
GSG
F
V
A
K
----------------
K
L
---
K
-----------
N
N
---
L
P
-
S
G
L
-
G
Y
D
F
S
G
E
V
I
E
-
L
G
S
D
V
N
----
N
V
N
I
G
D
K
V
M
---------------
G
I
A
-----------------------------
G
---------------------------
F
PDHP--------
C
C
Y
A
E
Y
V
C
A
S
P
D
T
I
I
Q
K
L
E
K
L
S
F
L
Q
A
A
S
L
P
T
A
G
L
T
A
L
Q
A
L
N
Q
-----
A
E
V
K
Q
G
D
V
V
L
I
H
A
G
A
G
G
V
G
H
L
A
I
Q
L
A
K
Q
--
K
G
T
T
V
I
T
T
A
S
K
R
N
H
A
F
L
K
A
L
G
A
E
Q
C
I
N
Y
H
E
E
--
D
F
L
------------------
L
A
-----------------------
I
------
S
T
P
V
D
A
V
I
D
L
V
G
G
D
V
G
I
Q
S
I
D
C
L
K
E
T
G
C
I
V
--------
S
V
P
T
I
T
A
G
R
V
I
E
V
A
K
Q
K
H
-
R
R
A
F
G
-
L
L
-----
K
Q
F
N
I
E
E
----
L
H
Y
L
G
K
-
L
V
-
S
E
-
D
--
K
L
R
--
I
E
I
S
R
I
F
Q
L
S
E
A
V
T
A
H
E
-
L
L
E
T
G
H
-
V
-
R
G
K
L
V
F
K
V
--
63
HHSearch
67.19
39%
-51
- C1 -
-
4DUP
-
?
B:
[7-331]
M
R
F
V
D
L
--
K
S
F
G
G
P
-
D
V
M
V
-
I
G
K
-
R
P
L
P
V
A
G
E
G
E
V
L
V
R
A
E
A
I
G
V
N
R
P
D
I
A
Q
R
Q
-----
G
S
----------------
Y
P
---
P
PK---------
D
A
---
S
P
-
I
-
L
-
G
L
E
L
S
G
E
I
V
G
-
V
G
P
--------
Y
A
V
G
D
K
V
C
---------------
G
L
A
-----------------------------
N
---------------------------
G
------------
G
A
Y
A
E
Y
C
L
L
P
A
G
Q
I
L
P
F
P
K
G
Y
D
A
V
K
A
A
A
L
P
E
T
F
F
T
V
W
A
N
L
F
Q
--
M
--
A
G
L
T
E
G
E
S
V
L
I
H
G
G
T
S
G
I
G
T
T
A
I
Q
L
A
R
A
F
G
A
-
E
V
Y
A
T
A
-------
A
C
E
R
L
G
A
K
R
G
I
N
Y
R
S
E
--
D
F
A
------------------
A
V
-----------------------
I
K
A
-
E
T
-
G
Q
G
V
D
I
I
L
D
M
I
G
A
A
Y
F
E
R
N
I
A
S
L
A
K
D
G
C
L
S
I
I
A
F
L
G
G
A
V
A
E
K
V
N
L
S
P
I
M
----
V
K
R
-
L
T
V
T
G
-
S
T
M
R
P
R
T
A
E
E
K
R
A
I
R
D
D
L
L
S
E
V
W
P
-
L
L
-
E
A
-
G
--
T
V
A
--
P
V
I
H
K
V
F
A
F
E
D
V
A
D
A
H
R
-
L
L
E
--------
K
V
M
L
T
V
--
70
HHSearch
64.63
30%
-17
- C1 -
-
1YB5
5
QOR_HUMAN
A:
[30-350]
M
R
A
V
R
V
--
F
E
F
G
G
P
-
E
V
L
K
-
L
R
S
D
I
A
V
P
I
P
K
D
H
Q
V
L
I
K
V
H
A
C
G
V
N
P
V
E
T
Y
I
R
S
-----
G
T
----------------
Y
S
---
R
KP---------
L
L
---
P
Y
-
T
-
P
-
G
S
D
V
A
G
V
I
E
A
-
V
G
D
N
A
S
----
A
F
K
K
G
D
R
V
F
---------------
T
S
S
T----------------------------
I
---------------------------
S
------------
G
G
Y
A
E
Y
A
L
A
A
D
H
T
V
Y
K
L
P
E
K
L
D
F
K
Q
G
A
A
I
G
I
P
Y
F
T
A
Y
R
A
L
I
H
--
S
--
A
C
V
K
A
G
E
S
V
L
V
H
G
A
S
G
G
V
G
L
A
A
C
Q
I
A
R
A
Y
G
L
-
K
I
L
G
T
A
G
T
E
E
G
Q
K
I
V
L
Q
N
G
A
H
E
V
F
N
H
R
E
V
--
N
Y
I
------------------
D
K
-----------------------
I
K
K
-
Y
V
G
E
K
G
I
D
I
I
I
E
M
L
A
N
V
N
L
S
K
D
L
S
L
L
S
H
G
G
R
V
I
V
V
G
S
R
G
T
I
E
---
I
N
P
R
D
T
M
----
A
K
E
-
S
S
I
I
G
-
V
T
L
F
S
S
T
---
K
E
E
F
Q
-
Q
Y
A
A
A
L
Q
A
-
G
M
-
E
I
-
G
--
W
L
K
--
P
V
I
G
S
Q
Y
P
L
E
K
V
A
E
A
H
E
-
N
I
I
H
G
S
G
A
-
T
G
K
M
I
L
L
---
68
HHSearch
64.48
27%
6
- C1 -
-
4Y1B
1
?
A:
[41-423]
M
Y
A
S
L
I
R
Q
E
R
Y
G
R
P
V
D
A
F
R
-
T
E
V
-
V
D
V
P
P
V
G
P
G
Q
V
L
V
K
V
M
A
A
G
V
N
Y
N
N
V
W
A
A
L
-----
G
E
----------------
P
L
---
D
V
I
A
A
R
Q
K
Q
GAT
E
D
---
F
H
-
I
-
G
-
G
S
D
L
S
G
I
V
W
A
-
V
G
D
G
V
-----
R
L
K
P
G
A
E
V
V
---------------
V
L
A
C
R
W
D
ESA
Q
D
I
R
L
GADPVTSST
Q
R
V
W
GYEE
N
---------------------------
Y
------------
G
S
F
A
Q
F
A
V
V
D
E
Y
M
C
H
P
K
P
Q
R
L
S
W
A
A
A
S
C
Y
M
A
T
A
A
T
A
Y
R
Q
L
F
G
--
W
EP
H
T
V
R
P
G
D
P
V
L
I
W
G
G
A
G
G
L
G
S
I
A
I
Q
L
V
R
H
V
G
G
-
I
P
V
A
V
V
S
S
E
E
R
G
E
F
C
M
R
L
G
A
K
G
W
I
D
R
R
E
F
--
D
H
W
------------------
G
R
LPDTTD
E
E
A
M
K
Q
W
L
D
G
A
R
A
F
G
R
R
F
W
E
V
L
G
E
R
R
A
P
R
I
V
L
E
H
S
G
A
D
T
I
P
T
S
I
Y
M
A
D
N
A
G
M
V
V
I
C
G
G
T
T
G
Y
N
-
G
D
V
D
L
R
F
L
W
----
M
R
Q
-
K
R
L
Q
G
-
S
H
A
A
S
-----
A
-----
R
E
A
R
E
I
T
R
-
L
I
-
D
Q
-
G
--
A
I
D
--
P
C
L
S
R
T
F
G
F
E
E
I
G
L
A
H
Q
-
L
I
H
D
N
Q
-
H
P
S
G
N
M
A
V
L
V
N
-
26
PsiBlast_CBE
64.00
31%
-13
- C1 -
-
1YB5
3
QOR_HUMAN
B:
[30-349]
M
R
A
V
R
V
--
F
E
F
G
G
P
-
E
V
L
K
L
R
S
D
-
I
A
V
P
I
P
K
D
H
Q
V
L
I
K
V
H
A
C
G
V
N
P
V
E
T
Y
I
R
S
G----
T
Y
----------------
S
R
---
K
-----------
P
L
---
L
P
-
Y
-
T
P
G
S
D
V
A
G
V
I
E
A
-
V
G
D
N
A
S
----
A
F
K
K
G
D
R
V
F
---------------
T
S
S
-----------------------------
T
---------------------------
I
S-----------
G
G
Y
A
E
Y
A
L
A
A
D
H
T
V
Y
K
L
P
E
K
L
D
F
K
Q
G
A
A
I
G
I
P
Y
F
T
A
Y
R
A
L
I
H
--
S
--
A
C
V
K
A
G
E
S
V
L
V
H
G
A
S
G
G
V
G
L
A
A
C
Q
I
A
R
A
Y
G
-
L
K
I
L
G
T
A
G
T
E
E
G
Q
K
I
V
L
Q
N
G
A
H
E
V
F
N
H
R
E
V
--
N
Y
I
------------------
D
K
-----------------------
I
K
K
-
Y
V
G
E
K
G
I
D
I
I
I
E
M
L
A
N
V
N
L
S
K
D
L
S
L
L
S
H
G
G
R
V
I
V
V
G
S
R
-
G
T
I
--
E
I
N
P
R
D
T
M
----
A
K
E
-
S
S
I
I
G
V
T
L
F
S
S
T
K
E
E
F
Q
Q
Y
A
A
A
L
---
Q
A
G
---
M
-
E
I
-
G
--
W
L
K
--
P
V
I
G
S
Q
Y
P
L
E
K
V
A
E
A
H
E
N
I
I
H
G
S
G
-
A
-
T
G
K
M
I
L
----
74
HHSearch
62.78
24%
-13
- C1 -
-
4A0S
4
?
C:
[49-414]
----------------
S
L
R
-
L
G
E
-
V
P
M
P
E
L
A
P
D
E
V
L
V
A
V
M
A
S
S
I
N
Y
N
T
V
W
S
A
M
-----
F
E
PIPTFHFLKQNARQGG
W
A
TRH
D
-----------
Q
P
---
Y
H
-
V
-
L
-
G
S
D
C
S
G
V
V
V
R
-
T
G
I
G
V
R
----
R
W
K
P
G
D
H
V
I
---------------
V
H
P
-----------------------------
A
HVDEQEPATHGDGMLGTEQRAWGFETN
F
------------
G
G
L
A
E
Y
G
V
V
R
A
S
Q
L
L
P
K
P
A
H
L
T
W
E
E
A
A
V
S
P
L
C
A
G
T
A
Y
R
M
L
V
S
DR
G
--
A
Q
M
K
Q
G
D
I
V
L
I
W
G
A
S
G
G
L
G
S
Y
A
I
Q
F
V
K
N
G
G
G
-
I
P
V
A
V
V
S
S
A
Q
K
E
A
A
V
R
A
L
G
C
D
L
V
I
N
R
A
E
L
--
G
I
T
DDIADDPRRVVETGRKLA
K
L
-----------------------
V
V
--
E
K
A
G
R
E
P
D
I
V
F
E
H
T
G
R
V
T
F
G
L
S
V
I
V
A
R
R
G
G
T
V
V
T
C
G
S
S
S
G
Y
L
-
H
T
F
D
N
R
Y
L
W
----
M
K
L
-
K
K
I
V
G
-
S
H
G
A
N
----------
H
E
E
Q
Q
A
T
N
R
-
L
F
-
E
S
-
G
--
A
V
V
--
P
A
M
S
A
V
Y
P
L
A
E
A
A
E
A
C
R
-
V
V
Q
T
S
R
-
Q
-
V
G
K
V
A
V
L
C
M
-
72
HHSearch
61.47
30%
-18
- C1 -
-
4RVU
1
?
C:
[5-332]
M
H
A
I
E
V
--
T
E
T
G
G
P
-
G
V
L
R
-
H
V
D
-
Q
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
-----
G
Q
----------------
Y
P
---
R
-----------
E
L
---
P
F
-
V
-
I
-
G
S
E
V
C
G
T
V
E
A
-
V
G
P
G
V
T
AADT
A
I
S
V
G
D
R
V
V
---------------
S
A
S
-----------------------------
A
---------------------------
N
------------
G
A
Y
A
E
F
C
T
A
P
A
S
L
T
A
K
V
P
D
D
V
T
S
E
V
A
A
S
A
L
L
K
G
L
T
A
H
Y
L
L
K
S
--
V
--
Y
P
V
K
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
V
-
R
V
I
T
T
V
S
T
A
E
K
A
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
P
E
D
A
W
Q
F
A
------------------
G
R
-----------------------
V
R
E
-
L
T
G
G
T
G
V
Q
A
V
Y
D
G
V
G
A
T
T
F
D
A
S
L
A
S
L
A
V
R
G
T
L
A
L
F
G
A
A
S
G
P
V
P
-
P
V
D
P
Q
R
L
N
----
A
A
G
S
V
Y
L
T
R
-
P
S
L
F
H
F
-
T
R
T
G
E
E
F
-
S
W
R
A
A
E
L
F
D
-
A
I
-
N
S
-
E
--
A
I
T
--
V
A
V
G
G
R
Y
P
L
A
D
A
L
R
A
H
Q
-
D
L
E
A
R
K
-
T
-
V
G
S
V
V
L
L
P
--
73
HHSearch
61.07
24%
-10
- C1 -
-
4A0S
4
?
B:
[49-414]
----------------
S
L
R
-
L
G
E
-
V
P
M
P
E
L
A
P
D
E
V
L
V
A
V
M
A
S
S
I
N
Y
N
T
V
W
S
A
M
-----
F
E
PIPTFHFLKQNARQGG
W
A
TRH
D
-----------
Q
P
---
Y
H
-
V
-
L
-
G
S
D
C
S
G
V
V
V
R
-
T
G
I
G
V
R
----
R
W
K
P
G
D
H
V
I
---------------
V
H
P
-----------------------------
A
HVDEQEPATHGDGMLGTEQRAWGFETN
F
------------
G
G
L
A
E
Y
G
V
V
R
A
S
Q
L
L
P
K
P
A
H
L
T
W
E
E
A
A
V
S
P
L
C
A
G
T
A
Y
R
M
L
V
S
DR
G
--
A
Q
M
K
Q
G
D
I
V
L
I
W
G
A
S
G
G
L
G
S
Y
A
I
Q
F
V
K
N
G
G
G
-
I
P
V
A
V
V
S
S
A
Q
K
E
A
A
V
R
A
L
G
C
D
L
V
I
N
R
A
E
L
--
G
I
T
DDIADDPRRVVETGRKLA
K
L
-----------------------
V
V
--
E
K
A
G
R
E
P
D
I
V
F
E
H
T
G
R
V
T
F
G
L
S
V
I
V
A
R
R
G
G
T
V
V
T
C
G
S
S
S
G
Y
L
-
H
T
F
D
N
R
Y
L
W
----
M
K
L
-
K
K
I
V
G
-
S
H
G
A
N
----------
H
E
E
Q
Q
A
T
N
R
-
L
F
-
E
S
-
G
--
A
V
V
--
P
A
M
S
A
V
Y
P
L
A
E
A
A
E
A
C
R
-
V
V
Q
T
S
R
-
Q
-
V
G
K
V
A
V
L
C
M
-
6
PsiBlast_PDB
61.05
31%
-16
- C1 -
-
1YB5
5
QOR_HUMAN
A:
[30-349]
M
R
A
V
R
V
--
F
E
F
G
G
P
-
E
V
L
K
L
R
S
D
-
I
A
V
P
I
P
K
D
H
Q
V
L
I
K
V
H
A
C
G
V
N
P
V
E
T
Y
I
R
S
G----
T
Y
----------------
S
R
---
K
-----------
P
L
---
L
P
-
Y
-
T
P
G
S
D
V
A
G
V
I
E
A
-
V
G
D
N
A
S
----
A
F
K
K
G
D
R
V
F
---------------
T
S
S
-----------------------------
T
---------------------------
I
S-----------
G
G
Y
A
E
Y
A
L
A
A
D
H
T
V
Y
K
L
P
E
K
L
D
F
K
Q
G
A
A
I
G
I
P
Y
F
T
A
Y
R
A
L
I
H
--
S
--
A
C
V
K
A
G
E
S
V
L
V
H
G
A
S
G
G
V
G
L
A
A
C
Q
I
A
R
A
Y
G
-
L
K
I
L
G
T
A
G
T
E
E
G
Q
K
I
V
L
Q
N
G
A
H
E
V
F
N
H
R
E
V
--
N
Y
I
------------------
D
K
-----------------------
I
K
K
-
Y
V
G
E
K
G
I
D
I
I
I
E
M
L
A
N
V
N
L
S
K
D
L
S
L
L
S
H
G
G
R
V
I
V
V
G
S
R
-
G
T
I
--
E
I
N
P
R
D
T
M
----
A
K
E
-
S
S
I
I
G
V
T
L
F
S
S
T
K
E
E
F
Q
Q
Y
A
A
A
L
---
Q
A
G
---
M
-
E
I
-
G
--
W
L
K
--
P
V
I
G
S
Q
Y
P
L
E
K
V
A
E
A
H
E
N
I
I
H
G
S
G
-
A
-
T
G
K
M
I
L
----