@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y2B1: (2018-01-29 )
MMEKYQNIVIGFGKGGKTLAKALASKGESVLVVEKSTRMYGGTCINIGCIPSKSLIFNGERGIDFTEAVARKEKLTGMLRAKNYHMISDEATGTVMDGTARFLSNHQIEVTNNGEKVIVEGERIFINTGSEPIILPIKGLNTSRYLIDSTQAMDQEQLPEKLVIIGAGYIGLEFASMFNEYGSKVVVLDAHSEFLPREDEDIAQMILEDMTNAGIEFHLGVSVDQVADQESTAAVTFTEDGQEVTIQASKVLAATGRKPSTASLGLENTDVKLTDRGAIAVDEYLRTDADNIWAIGDVKGGLQFTYISLDDYRIIMDQLKGENKRTTNNRKAVPYSVFITPTLSNVGLTEKQAKAQGVNYKLFKYMTSGVPKAQVLEDPKGVFKVLVDPETDLILGASIYAEDSHEVINLISLAMNGKLPYTLLRDQIYSHPTMSEALNDVLK
Atome Classification :
(20 SA)
.........10........20........30....-----....40........50....------.-------------..-----------------.60------------------.-------.----------......70........80....-....90........100.......110-.-..-.....120.......130....-...140.......150.......160.......170.......180.......190.......200.......210.......220.......230......--.-240.......250.......260.......270.......280.......290.......300....-...310.......320.......330.......340.......350.....--..360.......370.......380.......390.......400.......410.......420.......430.......440.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MME
K
Y
Q
N
I
V
I
G
FGK
G
G
K
T
L
A
K
A
L
ASKG
E
S
V
L
V
V
EK-----STRMYG
G
T
C
I
N
I
GCIPSK
S
L
------
I
-------------FN-----------------GER------------------G-------I----------
D
F
T
E
A
V
A
R
K
E
K
L
T
G
M
LRAK
N
Y
H
-
M
ISDEATGTV
M
D
G
T
A
R
F
L
SN
H
Q
I
E
V
-T-N-NG-
E
K
V
I
VEG
E
R
I
F
INTGS
E
P
I
I
L
P
-
I
KGLNTS
R
Y
L
IDSTQAM
D
Q
E
QLP
E
K
L
V
I
I
GA
G
Y
I
G
L
E
F
A
S
M
F
N
EYG
S
K
V
V
V
LDAHSEFLPRE
D
E
D
I
A
Q
M
I
L
E
D
M
TNA
G
I
E
F
H
LGV
S
V
D
Q
VADQES
T
A
A
V
T
FT--E-DG
Q
E
V
T
I
Q
A
S
K
V
L
AATGRKPSTASLGLENT
D
V
K
L
TDRG
A
I
A
V
D
E
Y
L
RTDAD
N
I
W
A
I
GDVKGG
L
Q
F
T
Y
-ISL
D
D
Y
R
I
I
M
D
Q
LKGENKRTTNNRKA
V
P
Y
S
V
F
I
T
PTLSNVGL
T
E
K
Q
AKAQG--V
N
Y
K
L
F
K
Y
M
T
SGV
P
K
A
Q
VLEDP
K
G
V
F
K
V
L
VDPET
D
L
I
L
G
A
S
I
YAE
D
S
H
E
V
I
N
L
I
S
L
AMNGKL
P
Y
T
L
L
R
D
Q
IYSHP
T
M
S
E
A
L
N
D
V
LK
12
PsiBlast_PDB
83.27
30%
-1
- C3 -
-
4M52
4
DLDH_MYCTU
A:
[3-456]
-
M
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-------
K
Y
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
------
L
-------------
R
N
A
E
L
V
H
I
F
T
K
DAKAFGIS
G
E
V
------------------
T
-------
F
----------
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
-
R
V
A
G
V
H
-
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
T
L
L
V
D
L
-
N
-
D
G
-
G
T
E
S
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
---
G
T
S
L
S
A
N
V
V
T
Y
E
E
Q
I
L
S
R
E
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
D
A
D
V
S
K
E
I
E
K
Q
F
K
K
L
G
V
T
I
L
T
A
T
K
V
E
S
I
A
D
G
G
S
Q
V
T
V
T
V
T
--
K
-
D
G
V
A
Q
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
L
L
Q
L
A
H
-
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
L
T
L
G
D
H
R
M
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
--
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
-
47
HHSearch
81.13
32%
-4
- C3 -
-
4M52
4
DLDH_MYCTU
B:
[2-457]
S
M
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-----
K
--
Y
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
------
L
-------------
R
N
-----------------
A
E
L
VHIFTKDAKAF-------
G
-------
I
SGEVTF----
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
-
V
A
G
V
H
-
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
T
L
L
V
-
D
-
L
-
N
D
G
G
T
E
S
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
-
G
T
S
L
S
--
A
N
V
V
T
Y
E
E
Q
I
L
S
R
E
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
D
A
D
V
S
K
E
I
E
K
Q
F
K
K
L
G
V
T
I
L
T
A
T
K
V
E
S
I
A
D
G
G
S
Q
V
T
V
T
V
T
--
K
-
D
G
V
A
Q
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
L
L
Q
L
A
H
-
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
L
T
L
G
D
H
R
M
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
--
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
H
54
HHSearch
80.23
33%
10
- C3 -
-
3URH
2
?
A:
[26-482]
----
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
K
-----
R
-
S
T
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
------
L
-------------
H
A
-----------------
S
E
M
F
H
Q
A
Q
HGLEAL-------
G
V
E
V
A
NPK
L
----------
N
L
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
-
V
D
G
V
S
-
F
L
F
K
K
N
K
I
D
G
F
Q
G
T
G
K
V
L
G
Q
G
K
V
S
V
-
T
-
N
-
E
K
G
E
E
Q
V
L
E
A
K
N
V
V
I
A
T
G
S
D
V
A
G
I
P
G
V
E
V
A
F
D
E
K
T
I
V
S
S
T
G
A
L
A
L
E
K
V
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
G
M
D
G
E
V
A
K
Q
L
Q
R
M
L
T
K
Q
G
I
D
F
K
L
G
A
K
V
T
G
A
V
K
S
G
D
G
A
K
V
T
F
E
PV
K
-
G
G
E
A
T
T
L
D
A
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
L
D
S
R
G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
V
R
G
P
M
L
A
H
-
K
A
E
D
E
G
V
A
V
A
E
I
I
A
G
Q
A
G
--
H
V
N
Y
D
V
I
P
G
V
V
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
--
V
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
G
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
C
H
A
H
P
T
M
S
E
A
V
K
E
A
A
L
11
PsiBlast_PDB
80.16
30%
1
- C3 -
-
3II4
3
DLDH_MYCTU
A:
[4-456]
--
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-------
K
Y
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
------
L
-------------
R
N
A
E
L
V
H
I
F
T
K
DAKAFGIS
G
E
V
------------------
T
-------
F
----------
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
-
R
V
A
G
V
H
-
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
T
L
L
V
D
L
-
N
-
D
G
-
G
T
E
S
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
---
G
T
S
L
S
A
N
V
V
T
Y
E
E
Q
I
L
S
R
E
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
D
A
D
V
S
K
E
I
E
K
Q
F
K
K
L
G
V
T
I
L
T
A
T
K
V
E
S
I
A
D
G
G
S
Q
V
T
V
T
V
T
--
K
-
D
G
V
A
Q
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
L
L
Q
L
A
H
-
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
L
T
L
G
D
H
R
M
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
--
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
-
27
PsiBlast_CBE
79.29
31%
15
- C3 -
-
5U8U
4
DLDH2_PSEAE
D:
[4-463]
M
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
YIGKE
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
------
L
-------------
D
S
-----------------
S
Y
K
YHEAKEAFKVHGIEAKGV
T
-------
I
----------
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
-
L
F
K
A
N
G
V
-
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
-
T
-
G
L
D
G
-
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
-
P
A
P
L
-
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
A
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
K
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
E
V
K
K
K
Q
V
T
V
T
F
T
--
D
-
A
N
G
E
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
R
G
A
M
L
A
H
-
K
A
S
E
E
G
V
M
V
A
E
R
I
A
G
H
K
A
Q
M
--
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
VE
V
N
V
G
T
F
P
F
A
A
S
G
--
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
---
8
PsiBlast_PDB
79.20
32%
-10
- C3 -
-
2YQU
2
?
A:
[2-443]
----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
-----
E
-
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
-------------
Y
E
-----------------
A
K
K
------------------
G
-------
L
LGAKVK
G
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
-
Q
A
N
T
Q
G
V
E
-
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
L
V
-
E
-
E
-
T
G
-
E
E
L
--
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
-
W
A
Q
V
D
Y
E
R
-
V
V
T
S
T
E
A
L
S
F
P
E
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
G
A
R
V
E
L
-----
E
G
G
E
V
-
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
H
---
V
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
--
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
---
43
HHSearch
78.95
30%
-9
- C3 -
-
1LVL
2
DLDH1_PSEPU
A:
[2-448]
Q
T
I
Q
T
T
L
L
I
I
G
G
G
P
G
G
Y
V
A
A
I
R
A
G
Q
L
G
I
P
T
V
L
V
E
G
-------
Q
A
L
G
G
T
C
L
N
I
G
C
I
P
S
K
A
L
------
I
-------------
H
V
-----------------
A
E
Q
F
H
Q
A
S
R
F
T
E
PSPL-----
G
I
S
V
A
SPR
L
----------
D
I
G
Q
S
V
A
W
K
D
G
I
V
D
R
L
-
T
T
G
V
A
-
A
L
L
K
K
H
G
V
K
V
V
H
G
W
A
K
V
L
D
G
K
Q
V
E
V
-
D
-------
G
Q
R
I
Q
C
E
H
L
L
L
A
T
G
S
S
S
V
E
L
P
-
M
L
P
L
G
--
G
P
V
I
S
S
T
E
A
L
A
P
K
A
L
P
Q
H
L
V
V
V
G
G
G
Y
I
G
L
E
L
G
I
A
Y
R
K
L
G
A
Q
V
S
V
V
E
A
R
E
R
I
L
P
T
Y
D
S
E
L
T
A
P
V
A
E
S
L
K
K
L
G
I
A
L
H
L
G
H
S
V
E
G
Y
E
N
G
----
C
L
L
A
N
--
D
G
K
G
G
Q
L
R
L
E
A
D
R
V
L
V
A
V
G
R
R
P
R
T
K
G
F
N
L
E
C
L
D
L
K
M
N
-
G
A
A
I
A
I
D
E
R
C
Q
T
S
M
H
N
V
W
A
I
G
D
V
A
G
E
P
M
L
A
H
-
R
A
M
A
Q
G
E
M
V
A
E
I
I
A
G
K
A
R
--
R
F
E
P
A
A
I
A
A
V
C
F
T
D
P
E
V
V
V
V
G
K
T
P
E
Q
A
S
Q
Q
G
--
L
D
C
I
V
A
Q
F
P
F
A
A
N
G
R
A
M
S
L
E
S
K
S
G
F
V
R
V
V
A
R
R
D
N
H
L
I
L
G
W
Q
A
V
G
V
A
V
S
E
L
S
T
A
F
A
Q
S
L
E
M
G
A
C
L
E
D
V
A
G
T
I
H
A
H
P
T
L
G
E
A
V
Q
E
A
A
-
26
PsiBlast_CBE
78.86
31%
17
- C3 -
-
5U8V
14
?
B:
[5-463]
-
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
Y
IGKE
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
------
L
-------------
D
S
-----------------
S
Y
K
Y
H
E
A
K
EAFKVHG
I
E
A
K
G
V
T
-------
I
----------
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
-
L
F
K
A
N
G
V
-
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
-
T
-
G
L
D
G
-
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
-
P
A
P
L
-
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
A
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
K
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
E
V
K
K
K
Q
V
T
V
T
F
T
--
D
-
A
N
G
E
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
R
G
A
M
L
A
H
-
K
A
S
E
E
G
V
M
V
A
E
R
I
A
G
H
K
A
Q
M
--
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
--
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
---
21
PsiBlast_CBE
78.75
31%
15
- C3 -
-
5U8W
8
?
D:
[6-463]
--
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
YIGKE
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
------
L
-------------
D
S
-----------------
S
Y
K
YHEAKEAFKVHGIEAKGV
T
-------
I
----------
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
-
L
F
K
A
N
G
V
-
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
-
T
-
G
L
D
G
-
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
-
P
A
P
L
-
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
A
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
K
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
E
V
K
K
K
Q
V
T
V
T
F
T
--
D
-
A
N
G
E
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
R
G
A
M
L
A
H
-
K
A
S
E
E
G
V
M
V
A
E
R
I
A
G
H
K
A
Q
M
--
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
VE
V
N
V
G
T
F
P
F
A
A
S
G
--
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
---
24
PsiBlast_CBE
78.60
31%
14
- C3 -
-
5U8V
5
?
D:
[4-463]
M
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
YIGKE
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
------
L
-------------
D
S
-----------------
S
Y
K
YHEAKEAFKVHGIEAKGV
T
-------
I
----------
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
-
L
F
K
A
N
G
V
-
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
-
T
-
G
L
D
G
-
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
-
P
A
P
L
-
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
A
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
K
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
E
V
K
K
K
Q
V
T
V
T
F
T
--
D
-
A
N
G
E
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
R
G
A
M
L
A
H
-
K
A
S
E
E
G
V
M
V
A
E
R
I
A
G
H
K
A
Q
M
--
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
VE
V
N
V
G
T
F
P
F
A
A
S
G
--
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
---
32
PsiBlast_CBE
78.58
32%
-8
- C3 -
-
2EQ7
3
?
B:
[2-443]
----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
-----
E
-
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
LETTER
I
-------------
Y
E
-----------------
A
K
K
------------------
G
-------
L
LGAKVKGVEL
D
L
P
A
L
M
A
H
K
D
K
V
V
-
Q
A
N
T
Q
G
V
E
-
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
L
V
-
E
-
E
-
T
G
-
E
E
L
--
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
-
W
A
Q
V
D
Y
E
R
-
V
V
T
S
T
E
A
L
S
F
P
E
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
G
A
R
V
E
L
-----
E
G
G
E
V
-
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
H
---
V
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
--
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
---
1
PsiBlast_PDB
78.50
31%
18
- C3 -
-
5U8U
12
DLDH2_PSEAE
A:
[6-463]
--
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
Y
I
G
KE
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
------
L
-------------
D
S
-----------------
S
Y
K
Y
H
E
A
K
EAFKVHGIEAK
G
V
T
-------
I
----------
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
-
L
F
K
A
N
G
V
-
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
-
T
-
G
L
D
G
-
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
-
P
A
P
L
-
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
A
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
K
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
E
V
K
K
K
Q
V
T
V
T
F
T
--
D
-
A
N
G
E
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
R
G
A
M
L
A
H
-
K
A
S
E
E
G
V
M
V
A
E
R
I
A
G
H
K
A
Q
M
--
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
--
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
---
13
PsiBlast_PDB
78.41
30%
-0
- C3 -
-
2A8X
3
DLDH_MYCTU
A:
[4-454]
----
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-------
K
Y
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
------
L
-------------
R
N
A
E
L
V
H
I
F
T
K
DAKAFG
I
S
G
E
V
------------------
T
-------
F
----------
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
-
R
V
A
G
V
H
-
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
T
L
L
V
D
L
-
N
-
D
G
-
G
T
E
S
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
---
G
T
S
L
S
A
N
V
V
T
Y
E
E
Q
I
L
S
R
E
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
D
A
D
V
S
K
E
I
E
K
Q
F
K
K
L
G
V
T
I
L
T
A
T
K
V
E
S
I
A
D
G
G
S
Q
V
T
V
T
V
T
--
K
-
D
G
V
A
Q
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
L
L
Q
L
A
H
-
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
L
T
L
G
D
H
R
M
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
--
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
-
31
PsiBlast_CBE
78.33
32%
-6
- C3 -
-
2YQU
2
?
B:
[2-443]
----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
-----
E
-
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
LETTER
I
-------------
Y
E
-----------------
A
K
K
------------------
G
-------
L
LGAKVKGVEL
D
L
P
A
L
M
A
H
K
D
K
V
V
-
Q
A
N
T
Q
G
V
E
-
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
L
V
-
E
-
E
-
T
G
-
E
E
L
--
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
-
W
A
Q
V
D
Y
E
R
-
V
V
T
S
T
E
A
L
S
F
P
E
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
G
A
R
V
E
L
-----
E
G
G
E
V
-
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
H
---
V
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
--
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
---
23
PsiBlast_CBE
78.33
31%
16
- C3 -
-
5U8W
11
?
B:
[5-463]
-
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
YIGKE
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
------
L
-------------
D
S
-----------------
S
Y
K
YHEAKEAFKVHGIEAKGV
T
-------
I
----------
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
-
L
F
K
A
N
G
V
-
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
-
T
-
G
L
D
G
-
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
-
P
A
P
L
-
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
A
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
K
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
E
V
K
K
K
Q
V
T
V
T
F
T
--
D
-
A
N
G
E
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
R
G
A
M
L
A
H
-
K
A
S
E
E
G
V
M
V
A
E
R
I
A
G
H
K
A
Q
M
--
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
VE
V
N
V
G
T
F
P
F
A
A
S
G
--
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
---
3
PsiBlast_PDB
78.29
31%
16
- C3 -
-
5U8W
11
?
A:
[5-463]
-
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
Y
IGKE
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
------
L
-------------
D
S
-----------------
S
Y
K
Y
H
E
A
K
EAFKVHG
I
E
A
K
GV
T
-------
I
----------
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
-
L
F
K
A
N
G
V
-
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
-
T
-
G
L
D
G
-
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
-
P
A
P
L
-
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
A
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
K
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
E
V
K
K
K
Q
V
T
V
T
F
T
--
D
-
A
N
G
E
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
R
G
A
M
L
A
H
-
K
A
S
E
E
G
V
M
V
A
E
R
I
A
G
H
K
A
Q
M
--
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
--
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
---
7
PsiBlast_PDB
78.21
32%
-8
- C3 -
-
2EQ7
3
?
A:
[2-443]
----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
-----
E
-
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
-------------
Y
E
-----------------
A
K
K
------------------
G
-------
L
LGAKVK
G
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
-
Q
A
N
T
Q
G
V
E
-
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
L
V
-
E
-
E
-
T
G
-
E
E
L
--
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
-
W
A
Q
V
D
Y
E
R
-
V
V
T
S
T
E
A
L
S
F
P
E
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
G
A
R
V
E
L
-----
E
G
G
E
V
-
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
H
---
V
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
--
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
---
56
HHSearch
78.13
32%
-1
- C3 -
-
2A8X
3
DLDH_MYCTU
A:
[1-455]
-
M
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-----
K
--
Y
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
------
L
-------------
R
N
-----------------
A
E
L
V
H
I
F
T
K
DAKAF-------
G
I
S
G
E
V
T
-
F
----------
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
-
V
A
G
V
H
-
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
T
L
L
V
-
D
-
L
-
N
D
G
G
T
E
S
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
-
G
T
S
L
S
--
A
N
V
V
T
Y
E
E
Q
I
L
S
R
E
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
D
A
D
V
S
K
E
I
E
K
Q
F
K
K
L
G
V
T
I
L
T
A
T
K
V
E
S
I
A
D
G
G
S
Q
V
T
V
T
V
T
--
K
-
D
G
V
A
Q
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
L
L
Q
L
A
H
-
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
L
T
L
G
D
H
R
M
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
--
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
H
29
PsiBlast_CBE
77.82
31%
16
- C3 -
-
5U8U
17
DLDH2_PSEAE
B:
[4-463]
M
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
Y
IGKE
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
------
L
-------------
D
S
-----------------
S
Y
K
Y
H
E
A
K
EAFKVHGIEAKG
V
T
-------
I
----------
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
-
L
F
K
A
N
G
V
-
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
-
T
-
G
L
D
G
-
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
-
P
A
P
L
-
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
A
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
K
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
E
V
K
K
K
Q
V
T
V
T
F
T
--
D
-
A
N
G
E
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
R
G
A
M
L
A
H
-
K
A
S
E
E
G
V
M
V
A
E
R
I
A
G
H
K
A
Q
M
--
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
--
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
---
15
PsiBlast_PDB
77.71
30%
1
- C3 -
-
1ZK7
3
MERA_PSEAI
A:
[1-448]
M
E
P
P
V
Q
V
A
V
I
G
S
G
G
A
A
M
A
A
A
L
K
A
V
E
Q
G
A
Q
V
T
L
I
E
R
-----
G
T
--
I
G
G
T
C
V
N
V
G
C
V
P
S
K
I
M
------
I
R
A
A
H
I
A
H
L
R
R
ESP
F
D
-----------------
G
G
I
------------------
A
A
T
VPT--
I
----------
D
R
S
K
L
L
A
Q
Q
Q
A
R
V
D
E
L
R
H
A
K
Y
E
G
I
L
G
G
N
P
A
I
T
V
V
H
G
E
A
R
F
K
D
D
Q
S
L
T
V
-
R
L
N
-
E
G
-
G
E
R
V
V
M
F
D
R
C
L
V
A
T
G
A
S
P
A
V
P
P
-
I
P
G
L
K
E
S
P
Y
W
T
-
S
T
E
A
L
A
S
D
T
I
P
E
R
L
A
V
I
G
S
S
V
V
A
L
E
L
A
Q
A
F
A
R
L
G
S
K
V
T
V
L
A
R
N
T
L
F
F
-
R
E
D
P
A
I
G
E
A
V
T
A
A
F
R
A
E
G
I
E
V
L
E
H
T
Q
A
S
Q
V
A
H
M
D
G
E
F
V
L
T
T
T
--
H
-
G
----
E
L
R
A
D
K
L
L
V
A
T
G
R
T
P
N
T
R
S
L
A
L
D
A
A
G
V
T
V
N
A
Q
G
A
I
V
I
D
Q
G
M
R
T
S
N
P
N
I
Y
A
A
G
D
C
T
D
Q
P
Q
F
V
Y
-
V
A
A
A
A
G
T
R
A
A
I
N
M
T
G
G
D
A
A
L
--
D
L
T
A
M
P
A
V
V
F
T
D
P
Q
V
A
T
V
G
Y
S
E
A
E
A
H
H
D
G
--
I
E
T
D
S
R
T
L
T
L
D
N
V
P
R
A
L
A
N
F
D
T
R
G
F
I
K
L
V
I
E
E
G
S
H
R
L
I
G
V
Q
A
V
A
P
E
A
G
E
L
I
Q
T
A
A
L
A
I
R
N
R
M
T
V
Q
E
L
A
D
Q
L
F
P
Y
L
T
M
V
E
G
L
-----