@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK19_HUMAN: (2013-07-19 )
MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY
Atome Classification :
(103 SA)
.........10........20........30........40........50...----...----..----60---.........70........80.......----.----90........100.......110.......120.......130.......140.......150.......160.......170.......180-.......190.......200.......210.......220.......230.......240.......250.......260.......270....-...280.......290.......300..--.....310.......320.......330.....--..340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQI----EGT----GI----S----MSACREIALLRELKHPNVIALQKVFLSH----S----DRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNS-PLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEY-PTLQKDFRRTTYANSSLIKYMEKHKVKP--DSKVFLLLQKLLTMDPTKRITSEQALQDPYFQE--DPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY
112
HHSearch
94.21
91%
-130
- C1 -
3RGF
6
CDK8_HUMAN
A:
[3-355]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
-----
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
----
E
G
T
----
G
I
----
S
----
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
----
A
----
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
-------
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
-----------------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
Q
------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
T
L
M
K
D
F
R
R
N
T
Y
T
N
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
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E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
93.83
87%
-124
- C1 -
4F6S
6
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
----
E
G
T
----
G
I
----
S
----
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
----
A
----
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
--------
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
------------------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
-------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
T
L
M
K
D
F
R
R
N
T
Y
T
N
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
93.34
87%
-126
- C1 -
4F70
1
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
----
E
G
T
----
G
I
----
S
----
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
----
A
----
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
A
------
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
---------------------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
-------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
T
L
M
K
D
F
R
R
N
T
Y
T
N
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
93.10
87%
-125
- C1 -
4F7N
2
CDK8_HUMAN
A:
[3-363]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
----
E
G
T
----
G
I
----
S
----
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
----
A
----
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
------
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
------------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
Q
E
-----
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
T
L
M
K
D
F
R
R
N
T
Y
T
N
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
93.08
87%
-121
- C1 -
4F6W
10
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
----
E
G
T
----
G
I
----
S
----
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
----
A
----
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
-----
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
-------------------
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
Q
------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
T
L
M
K
D
F
R
R
N
T
Y
T
N
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
93.01
87%
-123
- C1 -
4F7S
8
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
----
E
G
T
----
G
I
----
S
----
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
----
A
----
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
------
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
-
P
L
K
P
---------
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
-----
T
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
T
L
M
K
D
F
R
R
N
T
Y
T
N
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
92.89
91%
-122
- C1 -
4F6U
10
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
----
E
G
T
----
G
I
----
S
----
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
----
A
----
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
-----
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
------------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
Q
E
-----
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
T
L
M
K
D
F
R
R
N
T
Y
T
N
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
92.00
87%
-122
- C1 -
4F7L
1
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
----
E
G
T
----
G
I
----
S
----
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
----
A
----
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
-------
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
---------------------
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
Q
------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
T
L
M
K
D
F
R
R
N
T
Y
T
N
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
90.81
87%
-126
- C1 -
4F7J
3
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
----
E
G
T
----
G
I
----
S
----
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
----
A
----
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
---------
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
-------------------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
Q
------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
T
L
M
K
D
F
R
R
N
T
Y
T
N
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
66.60
40%
-107
- C1 -
3S00
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
66.27
40%
-104
- C1 -
3QZH
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
66.16
40%
-105
- C1 -
3R6X
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
66.04
40%
-105
- C1 -
3R83
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
66.03
40%
-104
- C1 -
3PJ8
1
CDK2_HUMAN
A:
[10-297]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R---
E
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
65.92
40%
-104
- C1 -
3R1S
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
65.90
40%
-103
- C1 -
3R1Y
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
65.89
40%
-107
- C1 -
3R8Z
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
----
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
65.82
40%
-105
- C1 -
3R73
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
65.77
40%
-103
- C1 -
3QQH
5
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
65.56
40%
-102
- C1 -
3R28
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
65.49
40%
-107
- C1 -
3R7E
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
65.48
40%
-103
- C1 -
3PY0
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
65.42
40%
-104
- C1 -
3R7U
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
65.32
40%
-99
- C1 -
3QQJ
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
65.19
40%
-106
- C1 -
3QTS
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
65.09
40%
-104
- C1 -
3RM7
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
65.04
40%
-104
- C1 -
3QZG
3
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
65.03
40%
-106
- C1 -
3R71
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
64.99
40%
-104
- C1 -
3QQF
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
64.97
40%
-105
- C1 -
3R8V
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
64.94
40%
-104
- C1 -
3R7V
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
64.90
40%
-105
- C1 -
3R8P
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
64.88
40%
-100
- C1 -
3R8U
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
64.85
40%
-118
- C1 -
3NIZ
1
?
A:
[16-307]
------------
F
Q
G
L
M
E
K
Y
Q
K
L
-
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
S
Q
---
G
R
I
V
A
L
K
R
I
----
R
------
G
I
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
H
S
----------
E
R
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
N
K
--------
T
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
S
D
----
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
-
P
V
R
------
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
G
K
P
L
F
P
G
V
T
D
D
---------
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
L
P
L
W
-
K
Q
R
T
--
F
--
Q
V
F
E
K
K
P
W
S
S
I
I
P
----
G
F
--
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
--
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
64.78
40%
-104
- C1 -
3RK5
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
64.76
40%
-103
- C1 -
3QL8
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
64.73
40%
-104
- C1 -
3QZI
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
64.71
40%
-103
- C1 -
3QTQ
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
64.66
40%
-101
- C1 -
3QQG
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
64.65
40%
-107
- C1 -
3RPR
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
64.63
40%
-106
- C1 -
3RJC
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
64.61
40%
-103
- C1 -
3R1Q
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
64.48
40%
-102
- C1 -
3PXF
7
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R
L
D
T
E
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
64.46
40%
-104
- C1 -
3ROY
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
64.42
40%
-102
- C1 -
3R7I
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
64.33
40%
-104
- C1 -
3RAI
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
64.33
40%
-100
- C1 -
3PXY
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
64.29
40%
-106
- C1 -
3R8L
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
64.25
40%
-101
- C1 -
3PXZ
3
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R
L
D
T
E
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
64.22
40%
-104
- C1 -
3RAH
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
64.22
40%
-102
- C1 -
3RPO
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
64.20
40%
-105
- C1 -
3R9N
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
64.14
40%
-104
- C1 -
3R7Y
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
64.06
40%
-104
- C1 -
4EZ3
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
63.77
40%
-99
- C1 -
3QU0
4
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
63.75
40%
-102
- C1 -
3QX2
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
63.59
40%
-102
- C1 -
3QXO
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
63.53
40%
-103
- C1 -
4FX3
2
CDK2_HUMAN
A:
[9-296]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R
LDT
E
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
63.52
40%
-104
- C1 -
4FX3
1
CDK2_HUMAN
C:
[9-296]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
RLDT
E
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
63.49
40%
-102
- C1 -
3QZF
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
63.43
40%
-105
- C1 -
3R9H
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
63.40
40%
-100
- C1 -
3RK7
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
63.29
40%
-103
- C1 -
3RNI
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
63.07
40%
-101
- C1 -
3QWK
5
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
62.85
40%
-104
- C1 -
3S0O
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R
L---
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
--
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
62.84
40%
-104
- C1 -
3QTZ
3
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
62.81
40%
-110
- C1 -
2IW8
1
CDK2_HUMAN
A:
[13-300]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R
L
D
T
E
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
H
V
D
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
62.80
40%
-99
- C1 -
3RK9
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
62.74
40%
-105
- C1 -
3QX4
3
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
62.72
40%
-100
- C1 -
3QRT
3
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
62.66
40%
-105
- C1 -
3RAL
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
62.59
40%
-103
- C1 -
3QQL
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
62.56
40%
-99
- C1 -
3QTX
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
62.55
40%
-103
- C1 -
3QXP
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
62.52
40%
-99
- C1 -
3QRU
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R
L---
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
62.27
40%
-99
- C1 -
3R9D
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
62.19
40%
-104
- C1 -
4GCJ
5
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R
L
DT
E
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
62.02
40%
-101
- C1 -
3RPV
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
62.00
40%
-102
- C1 -
3RMF
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R
L---------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
61.96
40%
-100
- C1 -
3RM6
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
-
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
61.93
40%
-100
- C1 -
3QQK
6
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
61.88
40%
-104
- C1 -
1OIT
1
CDK2_HUMAN
A:
[9-296]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
-
G
E
V
--
V
A
L
K
K
I
-----------------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
61.79
40%
-105
- C1 -
3RAK
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
61.61
40%
-103
- C1 -
3RPY
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
61.47
40%
-99
- C1 -
3R9O
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
61.44
40%
-100
- C1 -
3QWJ
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
61.12
40%
-101
- C1 -
3R8M
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
60.96
40%
-103
- C1 -
3EZV
1
CDK2_HUMAN
A:
[11-298]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R-----------
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
60.92
40%
-100
- C1 -
3RKB
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
60.92
40%
-98
- C1 -
3PXQ
4
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
60.89
40%
-97
- C1 -
3SQQ
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
-------
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
60.78
40%
-103
- C1 -
3S1H
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
60.73
40%
-99
- C1 -
3QTR
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
60.68
40%
-95
- C1 -
4EZ7
7
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
RLDT
E
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
60.13
40%
-95
- C1 -
3QTW
7
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
60.03
40%
-99
- C1 -
3QTU
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
59.87
40%
-93
- C1 -
3PY1
4
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R
L
D
T
E
T
E
----
G
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
59.65
40%
-101
- C1 -
3EZR
2
CDK2_HUMAN
A:
[11-298]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R-----------
V
----
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
59.43
40%
-102
- C1 -
3RZB
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
59.32
33%
-123
- C1 -
4B99
1
MK07_HUMAN
A:
[54-356]
-----------------
D
E
Y
E
I
I
-
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
--
L
T
G
Q
Q
V
A
I
K
K
I
----
P
N
A
----
F
D
V
V
T
N
A
----
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
----
V
PYGE
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
---------
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
----
C
E
L
K
I
G
D
F
G
M
A
R
G
L
-------
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
---------
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
-----
R
V
R
-
A
Y
I
Q
S
-
L
P
--
P
R
Q
P
V
P
W
E
T
V
Y
P
----
G
A
--
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
--
Y
H
D
P
D
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
58.17
33%
-113
- C1 -
4IC7
1
MK07_HUMAN
A:
[53-357]
---------------
V
G
D
E
Y
E
I
I
E
-
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
--
L
T
G
Q
Q
V
A
I
K
K
I
----
P
N
A
FDV
V
T
N
----
A
----
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
VPYG
E
----
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
---------
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
----
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
---------
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
-
A
Y
I
Q
S
-
L
P
--
P
R
Q
P
V
P
W
E
T
V
Y
----
P
G
A
--
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
--
Y
H
D
P
D
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
54.10
33%
-101
- C1 -
3ZDU
3
CDKL3_HUMAN
A:
[3-292]
-----------------
E
M
Y
E
T
L
G
-
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
N
--
T
G
Q
I
V
A
I
K
I
F
----
Y
------------
N
----
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
H
E
N
L
V
N
L
I
E
V
F
R
Q
----------
K
K
K
I
H
L
V
F
E
F
I
D
H
T
V
L
D
E
L
Q
H
Y
C
--------
H
G
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
----
G
I
T
K
L
C
D
F
G
F
A
R
T
------
D
I
Y
---
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
G
N
P
Y
L
P
S
S
S
D
---------
L
D
L
L
H
K
I
V
L
K
V
G
N
L
S
P
H
L
Q
N
I
F
S
K
S
P
I
F
-
A
G
V
V
L
P
--
Q
-
V
Q
H
P
K
N
A
R
K
K
Y
----
P
K
L
--
N
G
L
L
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
--
D
G
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
49.73
35%
-111
- C1 -
2FST
3
MK14_HUMAN
X:
[27-323]
---------------
V
P
E
R
Y
Q
N
L
S
-
P
V
G
----
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
L
----
S
R
P
----
F
Q
----
S
IIHA
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
----
R
SLEE
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
-----
Q
----------
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
----
C
E
L
K
I
L
D
----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
---------
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
S
S
E
S
A
R
--
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
N
V
F
----
I
G
A
--
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
--
Y
H
D
P
D
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------