@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : IRAK4_HUMAN: (2015-10-09 )
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Atome Classification :
(95 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200...--.-...-210.......220.......230.......240.......250........260.......270..-.-..----.-.280.......290.......300...---....310.......320.......330.......340.......350........-.360.-.----......370.......380--.-.....--.390---........400.......410......-.420-.---.-.......--430.......440.......450.......460
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNKPI
T
P
S
T
Y
V
R
C
L
N
V
G
L
I
R
K
L
S
D
FI
D
P
Q
E
G
W
K
K
L
A
V
A
I
KKPSGDDR
Y
N
Q
F
H
I
R
R
F
E
A
L
L
QTGKS
P
T
S
E
L
L
F
DWGTTNC
T
V
G
D
L
V
D
L
L
I
QNEFFA
P
A
S
L
LLPDAVPKTANTLPSKE
A
I
T
V
QQKQMPFCDKDR
T
L
M
T
P
V
Q
N
L
E
Q
SYMPPDSSSPENK
S
L
E
VSD
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
TNNFDERPISVGGNKMGEGG
F
G
V
V
Y
K
GYV--N-N
T
T
-
V
A
V
K
K
L
A
A
M
VDI
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
KCQHE
N
L
V
E
L
LGF-SSDGD
D
L
C
L
V
Y
V
YMPNG
S
L
L
D
R
L
-S-CL----D-GTPPL
S
W
H
M
R
C
K
IAQGAAN
G
I
N
F
LHEN---H
H
I
H
R
D
IKSA
N
I
L
LDEAFT
A
K
I
S
DFGL
A
R
A
S
E
K
F
A
Q
T
V
M
T
S
RIVG--T
T
A
YMA
P
E
-
A
LR-G-E----ITP
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
IT--G-LPAVD--EHR----EP
Q
L
L
L
D
I
K
E
EIE
D
E
E
K
T
I
E
D
Y
I
D
K
KM-ND---A---D-
S
T
S
V
E
A
M
--
Y
S
V
A
S
Q
C
L
H
E
KKNKRP
D
I
K
K
V
Q
Q
L
L
Q
E
MTAS--
5
PsiBlast_PDB
87.95
99%
-99
- C2 -
2OIC
1
IRAK4_HUMAN
A:
[4-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
--
N
-
N
T
T
-
V
A
V
K
K
-----------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
-
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
L
----
D
-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
---
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
------
T
V
M
T
S
R
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
R
-
G
-
E
----
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
--
E
H
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
D
---
A
---
D
-
S
T
S
V
E
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----
111
HHSearch
87.34
100%
-100
- C2 -
2NRU
1
IRAK4_HUMAN
A:
[11-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
--
N
-
N
T
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
-
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
L
----
D
-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
---
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
T
V
M
T
S
R
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
R
-
G
-
E
----
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
--
E
H
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
D
---
A
---
D
-
S
T
S
V
E
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----
22
PsiBlast_CBE
87.26
99%
-101
- C2 -
4U97
1
IRAK4_HUMAN
B:
[18-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
--
N
-
N
T
T
-
V
A
V
K
K
L
A
A
--------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
-
S
S
---
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
L
----
D
-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
---
H
H
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
------------
V
M
T
S
R
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
R
-
G
-
E
----
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
--
E
H
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
D
---
A
---
D
-
S
T
S
V
E
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----
4
PsiBlast_PDB
87.13
99%
-100
- C2 -
2NRU
1
IRAK4_HUMAN
A:
[11-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
--
N
-
N
T
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
-
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
L
----
D
-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
---
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
T
V
M
T
S
R
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
R
-
G
-
E
----
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
--
E
H
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
D
---
A
---
D
-
S
T
S
V
E
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----
21
PsiBlast_CBE
87.11
99%
-102
- C2 -
4U9A
1
IRAK4_HUMAN
B:
[18-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
--
N
-
N
T
T
-
V
A
V
K
K
L
A
A
--------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
-
S
S
---
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
L
----
D
-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
---
H
H
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
------------
V
M
T
S
R
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
R
-
G
-
E
----
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
--
E
H
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
D
---
A
---
D
-
S
T
S
V
E
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----
25
PsiBlast_CBE
87.01
99%
-98
- C2 -
2NRU
1
IRAK4_HUMAN
B:
[10-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
--
N
-
N
T
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
-
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
L
----
D
-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
---
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
T
V
M
T
S
R
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
R
-
G
-
E
----
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
--
E
H
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
D
---
A
---
D
-
S
T
S
V
E
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----
2
PsiBlast_PDB
87.01
99%
-103
- C2 -
4U9A
1
IRAK4_HUMAN
A:
[18-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
--
N
-
N
T
T
-
V
A
V
K
K
L
A
A
--------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
-
S
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
L
----
D
-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
---
H
H
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
--------
T
V
M
T
S
R
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
R
-
G
-
E
----
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
--
E
H
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
D
---
A
---
D
-
S
T
S
V
E
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----
3
PsiBlast_PDB
86.99
99%
-95
- C2 -
2NRY
1
IRAK4_HUMAN
A:
[11-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
--
N
-
N
T
T
-
V
A
V
K
K
L
A
A
---
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
-
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
L
----
D
-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
---
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
-----
T
V
M
T
S
R
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
R
-
G
-
E
----
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
--
E
H
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
D
---
A
---
D
-
S
T
S
V
E
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----
23
PsiBlast_CBE
86.95
99%
-97
- C2 -
2NRU
1
IRAK4_HUMAN
D:
[11-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
--
N
-
N
T
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
-
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
L
----
D
-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
---
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
T
V
M
T
S
R
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
R
-
G
-
E
----
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
--
E
H
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
D
---
A
---
D
-
S
T
S
V
E
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----
24
PsiBlast_CBE
86.18
99%
-97
- C2 -
2NRU
1
IRAK4_HUMAN
C:
[11-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
--
N
-
N
T
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
-
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
L
----
D
-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
---
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
T
V
M
T
S
R
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
R
-
G
-
E
----
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
--
E
H
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
D
---
A
---
D
-
S
T
S
V
E
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----
1
PsiBlast_PDB
86.17
99%
-105
- C2 -
4U97
1
IRAK4_HUMAN
A:
[18-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
--
N
-
N
T
T
-
V
A
V
K
K
L
A
A
--------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
-
S
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
L
----
D
-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
---
H
H
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
--------
T
V
M
T
S
R
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
R
-
G
-
E
----
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
--
E
H
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
D
---
A
---
D
-
S
T
S
V
E
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----
7
PsiBlast_PDB
72.58
99%
-44
- C2 -
4ZTM
1
?
A:
[3-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
--
N
-
N
T
T
-
V
A
V
K
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
-
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
L
----
D
-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
---
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
---
Q
T
V
M
T
S
R
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
R
-
G
-
E
----
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
--
E
H
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
D
---
A
---
D
-
S
T
S
V
E
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
---
6
PsiBlast_PDB
71.75
99%
-44
- C2 -
4YO6
1
IRAK4_HUMAN
A:
[4-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
--
N
-
N
T
T
-
V
A
V
K
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
-
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
L
----
D
-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
---
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
---
Q
T
V
M
T
S
R
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
R
-
G
-
E
----
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
--
E
H
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
D
---
A
---
D
-
S
T
S
V
E
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
---
12
PsiBlast_PDB
64.46
35%
-94
- C2 -
3UIM
1
BAK1_ARATH
A:
[15-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
L
K
R
F
S
L
R
E
L
Q
V
A
S
D
N
F
S
N
K
------
N
I
L
G
R
G
G
F
G
K
V
Y
K
G
R
L
A-
D
-
G
T
L
-
V
A
V
K
R
L
K
---
E
-----
G
E
L
Q
F
Q
T
E
V
E
M
I
S
M
A
V
H
R
N
L
L
R
L
R
G
F
-
C
M
T
P
T
E
R
L
L
V
Y
P
Y
M
A
N
G
S
V
A
----
S
-
C
L
RERP
E
-
S
Q
P
P
L
D
W
P
K
R
Q
R
I
A
L
G
S
A
R
G
L
A
Y
L
H
D
H
CDP
K
I
I
H
R
D
V
K
A
A
N
I
L
L
D
E
E
F
E
A
V
V
G
D
F
G
L
A
K
L
M
D
-
Y
K
D
T
H
V
T
T
A
V
R
G
--
T
I
G
H
I
A
P
E
-
Y
L
S
T
G
-
K
----
S
S
E
K
T
D
V
F
G
Y
G
V
M
L
L
E
L
I
T
--
G
-
Q
R
A
F
D
--
L
A
R
LA
N
D
D
D
V
M
L
L
D
W
V
K
G
L
L
-
K
E
K
K
L
E
A
L
V
D
V
D
L
Q
G
N
---
Y
---
K
-
D
E
E
V
E
Q
L
--
I
Q
V
A
L
L
C
T
Q
S
S
P
M
E
R
P
K
M
S
E
V
V
R
M
L
E
G
D
G
L
A
--
114
HHSearch
64.22
38%
-83
- C2 -
3UIM
1
BAK1_ARATH
A:
[15-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
L
K
R
F
S
L
R
E
L
Q
V
A
S
D
N
F
S
N
K
------
N
I
L
G
R
G
G
F
G
K
V
Y
K
G
R
L
A-
D
-
G
T
L
-
V
A
V
K
R
L
K
E
--------
G
E
L
Q
F
Q
T
E
V
E
M
I
S
M
A
V
H
R
N
L
L
R
L
R
G
F
-
C
M
T
P
T
E
R
L
L
V
Y
P
Y
M
A
N
G
S
V
A
S
C
L
-
R
-
E
R
P---
E
-
S
Q
P
P
L
D
W
P
K
R
Q
R
I
A
L
G
S
A
R
G
L
A
Y
L
H
D
H
CDP
K
I
I
H
R
D
V
K
A
A
N
I
L
L
D
E
E
F
E
A
V
V
G
D
F
G
L
A
K
L
M
D
Y
-
K
D
T
H
V
T
T
A
V
R
G
--
T
I
G
H
I
A
P
E
-
Y
L
S
-
T
G
K
----
S
S
E
K
T
D
V
F
G
Y
G
V
M
L
L
E
L
I
T
--
G
-
Q
R
A
F
D
--
L
A
R
LA
N
D
D
D
V
M
L
L
D
W
V
K
G
L
L
-
K
E
K
K
L
E
A
L
V
D
V
D
L
Q
G
N
---
Y
---
K
-
D
E
E
V
E
Q
L
--
I
Q
V
A
L
L
C
T
Q
S
S
P
M
E
R
P
K
M
S
E
V
V
R
M
L
E
G
D
G
L
A
--
115
HHSearch
61.77
37%
-66
- C2 -
4OA2
1
A:
[6-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
R
K
L
A
F
A
D
L
L
Q
A
T
N
G
F
H
N
------
D
S
L
I
G
S
G
G
F
G
D
V
Y
K
A
I
L
K-
D
-
G
S
A
-
V
A
I
K
K
L
I
H
V
S
G
----
Q
G
D
R
E
F
M
A
E
M
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
-
C
K
V
G
D
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
-
H
-
D
P
K---
K
-
A
G
V
K
L
N
W
S
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
CSP
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
R
L
M
S
A
M
D
T
H
L
S
V
S
T
L
A
G
--
T
P
G
Y
V
P
P
E
-
Y
Y
Q
-
S
F
R
----
C
S
T
K
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
--
G
-
K
R
P
T
D
--
S
---------------
K
Q
H
--
A
K
L
R
I
S
D
V
F
D
P
E
L
-
M
K
EDP
A
---
L
-
E
I
E
L
L
Q
H
--
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
T
M
V
Q
V
M
A
M
F
K
E
I
Q
A
---
17
PsiBlast_PDB
61.71
34%
-80
- C2 -
4OH4
1
BRI1_ARATH
A:
[32-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
A
D
L
L
Q
A
T
N
G
F
H
N
D
S
L
------
I
G
S
G
G
F
G
D
V
Y
K
A
I
L
K-
D
-
G
S
A
-
V
A
I
K
K
L
I
H
V
----
S
G
Q
G
D
R
E
F
M
A
E
M
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
-
C
K
V
G
D
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
-
H
D-----------
K
L
N
W
S
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
CSP
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
R
L
M
S
A
M
D
T
H
L
S
V
S
T
L
A
G
--
T
P
G
Y
V
P
P
E
-
Y
Y
Q
-
S
F
R
----
C
S
T
K
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
--
G
-
K
R
P
T
D
SP
D
F
G
----
D
N
N
L
V
G
W
V
K
Q
H
---
A
K
L
R
I
S
D
V
F
D
P
E
L
-
M
K
---
E
---
D
P
A
L
E
I
E
L
L
Q
H
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
T
M
V
Q
V
M
A
M
F
K
E
I
Q
A
---
112
HHSearch
61.53
36%
-71
- C2 -
4OAC
2
A:
[6-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
R
K
L
A
F
A
D
L
L
Q
A
T
N
G
F
H
N
------
D
S
L
I
G
S
G
G
F
G
D
V
Y
K
A
I
L
K-
D
-
G
S
A
-
V
A
I
K
K
L
I
H
V
S
G
Q
G
----
D
R
E
F
M
A
E
M
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
-
C
K
V
G
D
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
-
H
-
D
P
----
K
K
A
G
V
K
L
N
W
S
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
CSP
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
R
L
M
S
A
M
D
T
H
L
S
V
S
T
L
A
G
--
T
P
G
Y
V
P
P
E
-
Y
Y
Q
-
S
F
R
----
C
S
T
K
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
--
G
-
K
R
P
T
D
--
S
---------------
K
Q
H
--
A
K
L
R
I
S
D
V
F
D
P
E
L
-
M
K
---
E
DPA
L
-
E
I
E
L
L
Q
H
--
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
T
M
V
Q
V
M
A
M
F
K
E
I
Q
A
---
14
PsiBlast_PDB
58.08
34%
-63
- C2 -
4OA2
1
A:
[10-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
F
A
D
L
L
Q
A
T
N
G
F
H
N
D
S
L
------
I
G
S
G
G
F
G
D
V
Y
K
A
I
L
K-
D
-
G
S
A
-
V
A
I
K
K
L
I
H
V
----
S
G
Q
G
D
R
E
F
M
A
E
M
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
-
C
K
V
G
D
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
H
D
-
P
K
----
K
-
A
G
V
K
L
N
W
S
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
CSP
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
R
L
M
S
A
M
D
T
H
L
S
V
S
T
L
A
G
--
T
P
G
Y
V
P
P
E
-
Y
Y
Q
-
S
F
R
----
C
S
T
K
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
--
G
-
K
R
P
T
D
S
----------------
K
Q
H
---
A
K
L
R
I
S
D
V
F
D
P
E
L
-
M
K
---
E
---
D
P
A
L
E
I
E
L
L
Q
H
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
T
M
V
Q
V
M
A
M
F
K
E
I
Q
A
---
19
PsiBlast_PDB
58.01
34%
-69
- C2 -
4OAB
1
A:
[10-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
F
A
D
L
L
Q
A
T
N
G
F
H
N
D
S
L
------
I
G
S
G
G
F
G
D
V
Y
K
A
I
L
K-
D
-
G
S
A
-
V
A
I
K
K
L
I
H
V
----
S
G
Q
G
D
R
E
F
M
A
E
M
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
-
C
K
V
G
D
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
-
H
D
P
K
----
K
-
A
G
V
K
L
N
W
S
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
CSP
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
R
L
M
S
A
M
D
T
H
L
S
V
S
T
L
A
G
--
T
P
G
Y
V
P
P
E
-
Y
Y
Q
-
S
F
R
----
C
S
T
K
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
--
G
-
K
R
P
T
D
S
----------------
K
Q
H
---
A
K
L
R
I
S
D
V
F
D
P
E
L
-
M
K
---
E
---
D
P
A
L
E
I
E
L
L
Q
H
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
T
M
V
Q
V
M
A
M
F
K
E
I
Q
A
---
16
PsiBlast_PDB
57.97
34%
-68
- C2 -
4OAC
2
A:
[10-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
F
A
D
L
L
Q
A
T
N
G
F
H
N
D
S
L
------
I
G
S
G
G
F
G
D
V
Y
K
A
I
L
K-
D
-
G
S
A
-
V
A
I
K
K
L
I
H
V
----
S
G
Q
G
D
R
E
F
M
A
E
M
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
-
C
K
V
G
D
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
-
H
D
P
K
----
K
-
A
G
V
K
L
N
W
S
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
CSP
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
R
L
M
S
A
M
D
T
H
L
S
V
S
T
L
A
G
--
T
P
G
Y
V
P
P
E
-
Y
Y
Q
-
S
F
R
----
C
S
T
K
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
--
G
-
K
R
P
T
D
S
----------------
K
Q
H
---
A
K
L
R
I
S
D
V
F
D
P
E
L
-
M
K
---
E
---
D
P
A
L
E
I
E
L
L
Q
H
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
T
M
V
Q
V
M
A
M
F
K
E
I
Q
A
---
15
PsiBlast_PDB
56.97
34%
-65
- C2 -
4OA9
1
A:
[10-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
F
A
D
L
L
Q
A
T
N
G
F
H
N
D
S
L
------
I
G
S
G
G
F
G
D
V
Y
K
A
I
L
K-
D
-
G
S
A
-
V
A
I
K
K
L
I
H
V
----
S
G
Q
G
D
R
E
F
M
A
E
M
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
-
C
K
V
G
D
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
-
H
D
P
K
----
K
-
A
G
V
K
L
N
W
S
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
CSP
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
R
L
M
S
A
M
D
T
H
L
S
V
S
T
L
A
G
--
T
P
G
Y
V
P
P
E
-
Y
Y
Q
-
S
F
R
----
C
S
T
K
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
--
G
-
K
R
P
T
D
S
----------------
K
Q
H
---
A
K
L
R
I
S
D
V
F
D
P
E
L
-
M
K
---
E
---
D
P
A
L
E
I
E
L
L
Q
H
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
T
M
V
Q
V
M
A
M
F
K
E
I
Q
A
---
49
PsiBlast_CBE
56.50
31%
-84
- C2 -
3TV4
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
65
PsiBlast_CBE
56.47
31%
-74
- C2 -
3PPJ
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--------------
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
60
PsiBlast_CBE
56.46
31%
-77
- C2 -
3PRF
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--------------
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
68
PsiBlast_CBE
56.36
31%
-78
- C2 -
3IDP
1
B:
[33-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
----------------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
66
PsiBlast_CBE
56.27
31%
-75
- C2 -
3D4Q
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
48
PsiBlast_CBE
56.24
31%
-80
- C2 -
3TV6
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
--------
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
47
PsiBlast_CBE
56.22
31%
-80
- C2 -
3TV6
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
41
PsiBlast_CBE
56.20
31%
-77
- C2 -
4EHE
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
31
PsiBlast_CBE
56.10
31%
-82
- C2 -
4MBJ
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
102
Fugue
56.03
31%
-91
- C2 -
1BYG
1
CSK_HUMAN
A:
[15-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
---------------------
N
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
RG---
N
K
-
V
A
V
K
C
I
K
--------
N
D
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
--
E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
-
R
-
S
R
G------
R
S
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
---
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
-------------------LL
P
V
K
W
T
A
P
E
-
A
L
R
E
K
-
K
----
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
FG
R
-
V
P
Y
P
R
--
I
P
L
-----
K
D
V
V
P
R
V
E
K
-------------
G
Y
K
M
-
D
A
---
P
---
D
-
G
C
P
-
P
A
V
--
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
EL
33
PsiBlast_CBE
55.96
31%
-78
- C2 -
3II5
1
B:
[40-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
----------------
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
67
PsiBlast_CBE
55.93
31%
-73
- C2 -
3D4Q
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
55
PsiBlast_CBE
55.87
31%
-76
- C2 -
3PSD
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--------------
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
37
PsiBlast_CBE
55.85
31%
-78
- C2 -
4PP7
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
63
PsiBlast_CBE
55.84
31%
-76
- C2 -
3PPK
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--------------
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
29
PsiBlast_CBE
55.84
31%
-76
- C2 -
5CT7
1
?
A:
[18-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
----------------
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
64
PsiBlast_CBE
55.63
31%
-73
- C2 -
3PPJ
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
56
PsiBlast_CBE
55.62
31%
-76
- C2 -
3PSB
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
85
PsiBlast_CBE
55.61
31%
-75
- C2 -
2OFV
1
LCK_HUMAN
A:
[25-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
H
T
K
-
V
A
V
K
S
L
K
Q
-----
G
-------
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
P
----
S
-
G
I
K
-
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
---
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
--------------------
I
K
W
T
A
P
E
-
A
I
N
Y
G
-
T
----
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-----------
H
G
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
R
---
P
---
D
-
N
C
P
-
E
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
----
99
PsiBlast_CBE
55.43
31%
-71
- C2 -
4MXO
1
SRC_HUMAN
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
T
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
----
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
-
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
E
----
T
-
G
K
Y
-
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
---
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
------------
F
---
P
I
K
W
T
A
P
E
A
A
L
Y
-
G
-
R
----
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-----------
K
G
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
P
---
C
---
P
-
P
E
C
P
E
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
--
74
PsiBlast_CBE
55.28
31%
-79
- C2 -
5C9C
1
?
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
----
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
------------------
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
62
PsiBlast_CBE
55.26
31%
-78
- C2 -
3PPK
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
72
PsiBlast_CBE
55.18
31%
-78
- C2 -
4MNF
1
B:
[53-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
-----------------
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
54
PsiBlast_CBE
55.08
31%
-72
- C2 -
3PSD
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
44
PsiBlast_CBE
55.03
31%
-84
- C2 -
4E4X
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
28
PsiBlast_CBE
54.89
31%
-73
- C2 -
5CT7
1
?
B:
[18-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
-------------------
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
92
PsiBlast_CBE
54.88
31%
-72
- C2 -
2H8H
1
SRC_HUMAN
A:
[274-524]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
T
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
----
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
-
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
E
----
T
-
G
K
Y
-
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
---
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
R
Q
G
A
K
F
---
P
I
K
W
T
A
P
E
A
A
L
Y
-
G
-
R
----
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-----------
K
G
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
P
---
C
---
P
-
P
E
C
P
E
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
--
30
PsiBlast_CBE
54.86
31%
-72
- C2 -
4H58
1
BRAF_HUMAN
A:
[13-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
------------
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
35
PsiBlast_CBE
54.79
31%
-78
- C2 -
4KSP
1
BRAF_HUMAN
A:
[18-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
------------------
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
43
PsiBlast_CBE
54.77
31%
-81
- C2 -
4E4X
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
57
PsiBlast_CBE
54.74
31%
-77
- C2 -
3PSB
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--------------
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
36
PsiBlast_CBE
54.73
31%
-73
- C2 -
4FC0
1
BRAF_HUMAN
A:
[18-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
------------------
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
--NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
69
PsiBlast_CBE
54.69
31%
-73
- C2 -
3IDP
1
BRAF_HUMAN
A:
[33-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
---------------
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
32
PsiBlast_CBE
54.69
31%
-83
- C2 -
4MBJ
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
51
PsiBlast_CBE
54.56
31%
-75
- C2 -
3SKC
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
100
PsiBlast_CBE
54.49
31%
-72
- C2 -
4MXO
1
SRC_HUMAN
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
T
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
----
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
-
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
E
----
T
-
G
K
Y
-
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
---
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-----------
F
---
P
I
K
W
T
A
P
E
A
A
L
Y
-
G
-
R
----
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-----------
K
G
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
P
---
C
---
P
-
P
E
C
P
E
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
--
70
PsiBlast_CBE
54.41
31%
-72
- C2 -
1UWJ
1
B:
[13-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
K
-------------
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
77
PsiBlast_CBE
54.30
31%
-80
- C2 -
4EHG
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
----------------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
87
PsiBlast_CBE
54.27
31%
-71
- C2 -
2OF4
1
LCK_HUMAN
A:
[20-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
H
T
K
-
V
A
V
K
S
L
K
-----
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
P
----
S
-
G
I
K
-
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
---
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
R
E
G
A
K
F
---
P
I
K
W
T
A
P
E
-
A
I
N
Y
G
-
T
----
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-----------
H
G
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
R
---
P
---
D
-
N
C
P
-
E
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
--
86
PsiBlast_CBE
54.25
31%
-69
- C2 -
3BYU
1
LCK_HUMAN
A:
[26-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
H
T
K
-
V
A
V
K
S
L
K
Q
-----
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
P
----
S
-
G
I
K
-
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
---
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
---------------
K
F
---
P
I
K
W
T
A
P
E
-
A
I
N
Y
G
-
T
----
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-----------
H
G
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
R
---
P
---
D
-
N
C
P
-
E
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
--
95
PsiBlast_CBE
54.24
31%
-71
- C2 -
2BDF
1
SRC_HUMAN
A:
[18-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
T
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
----
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
-
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
E
----
T
-
G
K
Y
-
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
---
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-----------
F
---
P
I
K
W
T
A
P
E
A
A
L
Y
-
G
-
R
----
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-----------
K
G
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
P
---
C
---
P
-
P
E
C
P
E
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
--
71
PsiBlast_CBE
54.23
31%
-69
- C2 -
1UWJ
1
BRAF_HUMAN
A:
[13-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
K
S
------------
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
73
PsiBlast_CBE
54.17
31%
-75
- C2 -
4MNF
1
BRAF_HUMAN
A:
[53-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
-----------------
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
45
PsiBlast_CBE
54.17
31%
-71
- C2 -
4E26
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
-----------
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
94
PsiBlast_CBE
54.09
31%
-72
- C2 -
2BDF
1
SRC_HUMAN
B:
[18-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
T
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
----
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
-
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
E
----
T
-
G
K
Y
-
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
---
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------
A
K
F
---
P
I
K
W
T
A
P
E
A
A
L
Y
-
G
-
R
----
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-----------
K
G
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
P
---
C
---
P
-
P
E
C
P
E
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
--
93
PsiBlast_CBE
54.08
31%
-65
- C2 -
2BDJ
1
SRC_HUMAN
A:
[18-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
T
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
----
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
-
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
E
----
T
-
G
K
Y
-
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
---
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-----------
F
---
P
I
K
W
T
A
P
E
A
A
L
Y
-
G
-
R
----
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-----------
K
G
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
P
---
C
---
P
-
P
E
C
P
E
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
---
78
PsiBlast_CBE
53.98
31%
-74
- C2 -
4EHG
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
--------------
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
61
PsiBlast_CBE
53.97
31%
-76
- C2 -
3PRF
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--------------
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
34
PsiBlast_CBE
53.85
31%
-75
- C2 -
3II5
1
BRAF_HUMAN
A:
[40-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------
Q
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
27
PsiBlast_CBE
53.85
31%
-70
- C2 -
1UWH
1
BRAF_HUMAN
A:
[13-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
-
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
79
PsiBlast_CBE
53.82
31%
-82
- C2 -
3OMV
1
B:
[43-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
I
L
K
-
V
V
D
P
T
P
E
Q
F
-
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
M
T
K
-
D
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
-
H
-
V
Q
----
E
---
T
K
F
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
N
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
P
T
G
--
S
V
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DNNP
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
--
G
E
L
P
Y
S
H
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
A
S
P
D
L
-
S
K
---
L
---
Y
-
K
N
C
P
K
A
M
--
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
L
L
Q
H
S
--
98
PsiBlast_CBE
53.71
31%
-72
- C2 -
4MXX
1
SRC_HUMAN
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
T
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
----
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
-
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
E
----
T
-
G
K
Y
-
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
---
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
T
D
F
G
L
A
R
L
I
E
-----------
F
---
P
I
K
W
T
A
P
E
A
A
L
Y
-
G
-
R
----
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-----------
K
G
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
P
---
C
---
P
-
P
E
C
P
E
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
--
40
PsiBlast_CBE
53.71
31%
-69
- C2 -
4G9C
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
-----------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
76
PsiBlast_CBE
53.70
31%
-66
- C2 -
4G9R
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
K
S
------------
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
80
PsiBlast_CBE
53.66
31%
-80
- C2 -
3OMV
1
RAF1_HUMAN
A:
[43-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
I
L
K
-
V
V
D
P
T
P
E
Q
F
-
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
M
T
K
-
D
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
-
H
-
V
Q
----
E
---
T
K
F
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
N
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
P
T
G
--
S
V
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DNNP
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
--
G
E
L
P
Y
S
H
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
A
S
P
D
L
-
S
K
---
L
---
Y
-
K
N
C
P
K
A
M
--
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
L
L
Q
H
S
--
39
PsiBlast_CBE
53.59
31%
-70
- C2 -
4G9C
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
58
PsiBlast_CBE
53.56
31%
-72
- C2 -
3PRI
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
59
PsiBlast_CBE
53.48
31%
-71
- C2 -
3PRI
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
83
PsiBlast_CBE
53.45
31%
-68
- C2 -
2PL0
1
LCK_HUMAN
A:
[30-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
H
T
K
-
V
A
V
K
S
L
K
Q
-----
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
P
----
S
-
G
I
K
-
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
---
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
R
E
G
A
K
F
---
P
I
K
W
T
A
P
E
-
A
I
N
Y
G
-
T
----
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-----------
H
G
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
R
---
P
---
D
-
N
C
P
-
E
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
----
75
PsiBlast_CBE
53.44
31%
-69
- C2 -
4G9R
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
K
-------------
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
88
PsiBlast_CBE
53.40
31%
-72
- C2 -
2OF2
1
LCK_HUMAN
A:
[20-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
H
T
K
-
V
A
V
K
S
L
K
-----
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
P
----
S
-
G
I
K
-
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
---
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
R
E
G
A
K
F
---
P
I
K
W
T
A
P
E
-
A
I
N
Y
G
-
T
----
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-----------
H
G
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
R
---
P
---
D
-
N
C
P
-
E
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
--
52
PsiBlast_CBE
53.39
31%
-75
- C2 -
3SKC
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
----------------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
26
PsiBlast_CBE
53.19
31%
-70
- C2 -
1UWH
1
B:
[13-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
-
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
50
PsiBlast_CBE
53.15
31%
-79
- C2 -
3TV4
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
--
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
----------
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
84
PsiBlast_CBE
52.96
31%
-76
- C2 -
2OFV
1
?
B:
[25-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
H
T
K
-
V
A
V
K
S
L
K
Q
-----
G
-----
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
P
----
S
-
G
I
K
-
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
---
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
--------------
P
I
K
W
T
A
P
E
-
A
I
N
Y
G
-
T
----
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-----------
H
G
R
----
I
P
Y
P
-------
I
Q
N
L
E
-------
G
Y
R
M
-
V
R
---
P
---
D
-
N
C
P
-
E
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
---
42
PsiBlast_CBE
52.81
31%
-75
- C2 -
4EHE
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
----------
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
82
PsiBlast_CBE
52.65
31%
-66
- C2 -
3B2W
1
LCK_HUMAN
A:
[25-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
H
T
K
-
V
A
V
K
S
L
K
Q
-----
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
P
----
S
-
G
I
K
-
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
---
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
--
G
A
K
F
---
P
I
K
W
T
A
P
E
-
A
I
N
Y
G
-
T
----
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-----------
H
G
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
R
---
P
---
D
-
N
C
P
-
E
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
--
38
PsiBlast_CBE
52.40
31%
-82
- C2 -
4PP7
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
91
PsiBlast_CBE
52.39
31%
-59
- C2 -
3MPM
2
LCK_HUMAN
A:
[16-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
H
T
K
-
V
A
V
K
S
L
K
-----
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
P
----
S
-
G
I
K
-
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
---
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
R
----
F
---
P
I
K
W
T
A
P
E
-
A
I
N
Y
G
-
T
----
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-----------
H
G
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
R
---
P
---
D
-
N
C
P
-
E
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
----
46
PsiBlast_CBE
52.06
31%
-72
- C2 -
4E26
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
--
H
-
G
D
--
V
A
V
K
M
L
N
--
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
I
----
E
-
T
K
F
E
M
I
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
------
F
E
Q
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
R
-
M
-
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
--
I
N
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
K
---
V
---
R
-
S
N
C
P
K
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--
89
PsiBlast_CBE
51.94
31%
-67
- C2 -
2OG8
1
?
B:
[15-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
H
T
K
-
V
A
V
K
S
L
K
-----
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
P
----
S
-
G
I
K
-
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
---
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
-------------------
P
I
K
W
T
A
P
E
-
A
I
N
Y
G
-
T
----
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-----------
H
G
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
R
---
P
---
D
-
N
C
P
-
E
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
--
97
PsiBlast_CBE
51.57
31%
-72
- C2 -
4MXX
1
SRC_HUMAN
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
T
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
----
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
-
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
E
----
T
-
G
K
Y
-
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
---
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
T
D
F
G
L
----------------
F
---
P
I
K
W
T
A
P
E
A
A
L
Y
-
G
-
R
----
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-----------
K
G
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
P
---
C
---
P
-
P
E
C
P
E
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
--
90
PsiBlast_CBE
51.51
31%
-58
- C2 -
4C3F
1
LCK_HUMAN
A:
[16-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
H
T
K
-
V
A
V
K
S
L
K
-----
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
P
----
S
-
G
I
K
-
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
---
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
R
----
F
---
P
I
K
W
T
A
P
E
-
A
I
N
Y
G
-
T
----
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-----------
H
G
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
R
---
P
---
D
-
N
C
P
-
E
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
----