@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0217: (2015-11-29 )
MKTILAVETSCDETAVAIVNSEKQVLAQEILSQTEHKKRGGVIPEIASRAHMEHLSSLIKNSIEKSNLNFCNLDATAATSGPGLIGGLIVGTMMAKAIAHVTQKPFIAVNHLEAHVLVIRLLYEVKFPFLVLLISGGHCQFLIAQNVGKYIKLGETLDDSLGEAFDKVARMLGLSYPGGPLIEKLAKKGNGTRFKLPRAMRKRPGCNFSFSGIKTAVKNLVQELEMSEQDVCDVCASFQECISEILLDRVKNAVIMAESLNIKINDFVVTGGVAANNFLRKKLKKHINLNILFPPINLCTDNAVMVGWTGIEILQKDYIDSLNFAPRPRWELGSY
Atome Classification :
(20 SA)
.........10........20.......--.30..-..-..--..40........50........60........70........80........90........100.......110.......120-.---...---...130.......140.......150.......160.......170.......180.......190------.........200.......210.......220..---.....230.......240.......250.......260.......270.......280..---...--.---.---290-.........300.......310....-...-320....-....330...-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
T
I
L
A
V
ETSCD
E
T
A
V
A
I
VN
S
E
K
Q
V
L
A
Q
--
E
I
L
S
Q
-
T
E
-HK--KRGGV
I
P
E
I
A
S
R
A
H
M
E
H
L
S
S
L
I
K
N
S
I
E
KSNL
N
F
CNLDATAATSGP
G
L
I
G
G
L
I
V
G
T
M
M
A
K
A
I
A
H
V
TQK
P
F
I
A
V
N
H
L
E
A
H
V
L
V
I
R
L
L
-
Y
---EVK---F
P
F
L
V
L
L
I
SGG
H
C
Q
F
L
I
A
QNV
G
K
Y
I
KLG
E
T
L
D
D
S
L
G
E
A
F
D
K
V
A
R
M
LGLSYP
G
G
P
L
I
E
K
L
A
KKGN--------GTRFKL
P
R
A
M
R
KRPGCNF
S
F
S
G
I
K
T
A
V
K
N
L
V
Q
E
L
---EM
S
E
Q
D
V
C
D
V
C
A
S
F
Q
E
C
I
S
E
I
L
L
D
R
VKN
A
V
I
M
A
E
S
L
N
I
K
I
N
D
F
V
V
TG
G
V
A
A
N
N
F
L
R
K
K
L
K
---
K
HI--
N
---
L
---
N
---
I
L
FPPINLCTD
N
A
V
M
V
GW
T
G
I
E
I
L
Q
K
-
D
YI-D-SLNFA-PRPRWELGSY-----
22
PsiBlast_CBE
98.50
39%
-118
- C2 -
3ZEU
4
?
E:
[3-331]
---
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
K
K
G
L
L
A
N
--
Q
L
Y
S
Q
-
V
K
L
H
A
--
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
D
N
---
P
P
E
---
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
M
A
S
Q
G
T
--------
A
G
R
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
S
N
---
G
G
D
E
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
---
E
S
T
G
F
K
--
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
---
E
M
M
--
Q
---
K
---
R
RGE
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
-
G
V
T
-
A
-
D
L
G
V
T
-
V
R
P
R
W
P
L
A
E
L
-----
5
PsiBlast_PDB
98.23
39%
-120
- C2 -
4WQ5
5
TSAD_ECOLI
A:
[3-331]
---
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
N
--
Q
L
Y
S
Q
-
V
K
L
H
A
--
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
E
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
D
N
---
P
P
E
---
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
M
A
A
Q
G
T
--------
A
G
R
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
D
N
---
G
T
D
D
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
-----
Q
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
--
R
---
G
---
E
---
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
-
G
A
T
-
A
-
D
L
G
V
S
-
V
R
P
R
W
P
L
A
-------
4
PsiBlast_PDB
98.02
39%
-119
- C2 -
4WQ4
3
TSAD_ECOLI
A:
[3-331]
---
V
L
G
I
E
T
S
C
D
A
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
N
--
Q
L
Y
S
Q
-
V
K
L
H
A
--
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
D
N
---
P
P
E
---
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
M
A
A
Q
G
T
--------
A
G
R
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
D
N
---
G
T
D
D
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
-----
Q
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
--
R
---
G
---
E
---
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
-
G
A
T
-
A
-
D
L
G
V
S
-
V
R
P
R
W
P
L
A
E
L
-----
3
PsiBlast_PDB
97.65
39%
-117
- C2 -
3ZEU
5
?
B:
[3-331]
---
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
K
K
G
L
L
A
N
--
Q
L
Y
S
Q
-
V
K
L
H
A
--
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
D
N
---
P
P
E
---
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
M
A
S
Q
G
T
--------
A
G
R
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
S
N
---
G
G
D
E
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
---
E
S
T
G
F
K
--
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
---
E
M
M
--
Q
---
K
---
R
R
G
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
-
G
V
T
-
A
-
D
L
G
V
T
-
V
R
P
R
W
P
L
A
E
L
-----
2
PsiBlast_PDB
97.53
39%
-117
- C2 -
3ZET
2
?
B:
[3-331]
---
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
K
K
G
L
L
A
N
--
Q
L
Y
S
Q
-
V
K
L
H
A
--
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
D
N
---
P
P
E
---
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
M
A
S
Q
G
T
--------
A
G
R
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
S
N
---
G
G
D
E
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
---
E
S
T
G
F
K
--
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
---
E
M
M
--
Q
---
K
---
R
R
G
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
-
G
V
T
-
A
-
D
L
G
V
T
-
V
R
P
R
W
P
L
A
E
L
-----
23
PsiBlast_CBE
97.46
39%
-118
- C2 -
4WQ4
4
TSAD_ECOLI
B:
[3-331]
---
V
L
G
I
E
T
S
C
D
A
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
N
--
Q
L
Y
S
Q
-
V
K
L
H
A
--
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
D
N
---
P
P
E
---
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
M
A
A
Q
G
T
--------
A
G
R
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
D
N
---
G
T
D
D
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
-----
Q
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
EMM
K
K
R
--
R
---
G
---
E
---
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
-
G
A
T
-
A
-
D
L
G
V
S
-
V
R
P
R
W
P
L
A
E
L
-----
1
PsiBlast_PDB
96.93
39%
-117
- C2 -
4YDU
7
TSAD_ECOLI
A:
[3-331]
---
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
N
--
Q
L
Y
S
Q
-
V
K
L
H
A
--
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
D
N
---
P
P
E
---
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
M
A
A
Q
G
T
--------
A
G
R
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
D
N
---
G
T
D
D
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
-----
Q
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
--
R
---
G
---
E
---
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
-
G
A
T
-
A
-
D
L
G
V
S
-
V
R
P
R
W
P
L
A
E
L
-----
21
PsiBlast_CBE
96.88
39%
-116
- C2 -
4YDU
7
TSAD_ECOLI
B:
[3-331]
---
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
N
--
Q
L
Y
S
Q
-
V
K
L
H
A
--
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
D
N
---
P
P
E
---
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
M
A
A
Q
G
T
--------
A
G
R
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
D
N
---
G
T
D
D
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
-----
Q
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
EMM
K
K
R
--
R
---
G
---
E
---
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
-
G
A
T
-
A
-
D
L
G
V
S
-
V
R
P
R
W
P
L
A
E
L
-----
24
PsiBlast_CBE
96.65
39%
-115
- C2 -
4WQ5
4
TSAD_ECOLI
B:
[3-331]
---
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
N
--
Q
L
Y
S
Q
-
V
K
L
H
A
--
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
E
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
D
N
---
P
P
E
---
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
M
A
A
Q
G
T
--------
A
G
R
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
D
N
---
G
T
D
D
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
D
-----
Q
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
EMM
K
K
R
--
R
---
G
---
E
---
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
-
G
A
T
-
A
-
D
L
G
V
S
-
V
R
P
R
W
P
L
A
E
L
-----
31
HHSearch
95.03
37%
-112
- C2 -
3ZEU
5
?
B:
[1-333]
-
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
K
K
G
L
L
A
N
--
Q
L
Y
S
Q
V
K
L
-
H
A
--
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
E
-
D
NPP
E
F
----
P
F
V
A
L
L
V
S
G
G
H
T
Q
-
L
I
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
M
A
S
Q
G
T
--------
A
G
R
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
S
N
---
G
G
D
E
Q
T
R
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
C
K
R
A
L
E
S
T
-----
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
---
E
M
M
--
Q
K
R
R
G
---
E
---
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
-
G
V
T
-
A
-
D
L
G
V
T
-
V
R
P
R
W
P
L
A
E
L
-----
33
HHSearch
89.49
32%
-113
- C2 -
2IVN
3
KAE1_PYRAB
A:
[1-319]
-
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
S
E
-
D
K
V
L
A
N
V
F
D
T
L
T
------
T
--
E
K
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
-
G
---
V
K
----
D
P
V
G
L
Y
V
S
-
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
E
--------
K
Y
-
I
E
L
P
Y
A
V
---
K
G
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
------
G
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
T
-----
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
---
I
M
T
--
E
D
R
G
I
---
K
---
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
-
G
I
S
-
F
R
L
E
E
T
I
-
V
K
Q
K
F
R
T
D
E
V
-----
32
HHSearch
88.33
32%
-121
* C2 *
3EN9
1
KAE1B_METJA
A:
[5-322]
P
M
I
C
L
G
L
E
G
T
A
E
K
T
G
V
G
I
V
T
S
D
G
E
V
L
F
N
K
T
I
M
Y
K
------
P
--
P
K
Q
G
I
N
P
R
E
A
A
D
H
H
A
E
T
F
P
K
L
I
K
E
A
F
E
V
--
V
D
K
N
E
I
D
L
I
A
F
S
Q
G
P
G
L
G
P
S
L
R
V
T
A
T
V
A
R
T
L
S
L
T
L
K
K
P
I
I
G
V
N
H
C
I
A
H
I
E
I
G
K
L
T
-
T
---
E
A
----
E
D
P
L
T
L
Y
V
S
G
G
N
T
Q
V
I
A
Y
V
S
-
K
K
Y
R
V
F
G
E
T
L
D
I
A
V
G
N
C
L
D
Q
F
A
R
Y
V
N
L
P
H
P
G
G
P
Y
I
E
E
L
A
R
K
G
K
--------
K
L
-
V
D
L
P
Y
T
---
V
K
G
M
D
I
A
F
S
G
L
L
T
A
A
M
R
A
Y
-------
D
A
G
E
R
L
E
D
I
C
Y
S
L
Q
E
Y
A
F
S
M
L
T
E
I
T
E
R
A
L
A
H
T
-----
N
K
G
E
V
M
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
K
---
A
M
C
E
G
Q
N--
V
---
D
---
F
Y
V
P
P
K
E
F
C
G
D
N
G
A
M
I
A
W
L
G
L
L
M
H
K
N
-
G
R
W
M
S
-
L
D
E
T
K
-
I
I
P
N
Y
R
T
D
M
V
-----
26
PsiBlast_CBE
88.31
34%
-114
- C2 -
2IVO
3
KAE1_PYRAB
C:
[4-299]
----
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
V
L
A
N
--
V
F
D
T
L
-
T
T
-
E
K
----
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
--
F
---
G
V
K
---
D
P
-
V
G
L
Y
V
S
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
E
---------
K
Y
I
E
L
P
Y
A
V
K
---
G
M
D
L
S
F
S
G
L
L
T
---
E
A
I
R
K
Y
---
R
S
G
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
T
E
K
-----
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
IMT
E
D
R
--
G
---
I
---
K
---
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
-
G
I
S
-
F
-
R
L
E
E
T
-
I
V
K
Q
K
F
R
T
D
E
-----
7
PsiBlast_PDB
88.11
34%
-111
- C2 -
2IVN
3
KAE1_PYRAB
A:
[4-299]
----
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
V
L
A
N
--
V
F
D
T
L
-
T
T
-
E
K
----
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
--
F
---
G
V
K
---
D
P
-
V
G
L
Y
V
S
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
E
---------
K
Y
I
E
L
P
Y
A
V
K
---
G
M
D
L
S
F
S
G
L
L
T
---
E
A
I
R
K
Y
---
R
S
G
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
T
E
K
-----
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
--
G
---
I
---
K
---
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
-
G
I
S
-
F
-
R
L
E
E
T
-
I
V
K
Q
K
F
R
T
D
E
-----
9
PsiBlast_PDB
87.91
34%
-113
- C2 -
2IVP
2
KAE1_PYRAB
A:
[4-299]
----
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
V
L
A
N
--
V
F
D
T
L
-
T
T
-
E
K
----
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
--
F
---
G
V
K
---
D
P
-
V
G
L
Y
V
S
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
E
---------
K
Y
I
E
L
P
Y
A
V
K
---
G
M
D
L
S
F
S
G
L
L
T
---
E
A
I
R
K
Y
---
R
S
G
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
T
E
K
-----
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
--
G
---
I
---
K
---
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
-
G
I
S
-
F
-
R
L
E
E
T
-
I
V
K
Q
K
F
R
T
D
E
-----
25
PsiBlast_CBE
87.83
34%
-114
- C2 -
2IVO
2
KAE1_PYRAB
D:
[4-299]
----
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
V
L
A
N
--
V
F
D
T
L
-
T
T
-
E
K
----
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
--
F
---
G
V
K
---
D
P
-
V
G
L
Y
V
S
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
E
---------
K
Y
I
E
L
P
Y
A
V
K
---
G
M
D
L
S
F
S
G
L
L
T
---
E
A
I
R
K
Y
---
R
S
G
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
T
E
K
-----
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
IMT
E
D
R
--
G
---
I
---
K
---
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
-
G
I
S
-
F
-
R
L
E
E
T
-
I
V
K
Q
K
F
R
T
D
E
-----
8
PsiBlast_PDB
87.78
34%
-112
- C2 -
2IVO
3
KAE1_PYRAB
A:
[4-299]
----
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
V
L
A
N
--
V
F
D
T
L
-
T
T
-
E
K
----
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
--
F
---
G
V
K
---
D
P
-
V
G
L
Y
V
S
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
E
---------
K
Y
I
E
L
P
Y
A
V
K
---
G
M
D
L
S
F
S
G
L
L
T
---
E
A
I
R
K
Y
---
R
S
G
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
T
E
K
-----
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
--
G
---
I
---
K
---
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
-
G
I
S
-
F
-
R
L
E
E
T
-
I
V
K
Q
K
F
R
T
D
E
-----
52
Fugue
87.60
32%
-103
- C2 -
2IVN
3
KAE1_PYRAB
A:
[1-325]
-
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
S
E
D
K
---
V
L
--
A
N
V
F
D
-
T
L
-
T
T
--
E
K
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
-
G
---
V
-----
K
D
P
V
G
L
Y
V
S
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
E
---------
K
Y
I
E
L
P
Y
A
V
K
---
G
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
------
G
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
T
E
K
-----
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
---
I
M
T
--
E
---
D
R
G
I
K
---
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
-
G
I
S
-
F
-
R
L
E
E
T
I
V
K
Q
K
F
R
T
D
E
V
EIVWH
27
PsiBlast_CBE
87.14
34%
-112
- C2 -
2IVO
2
KAE1_PYRAB
B:
[4-299]
----
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
V
L
A
N
--
V
F
D
T
L
-
T
T
-
E
K
----
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
--
F
---
G
V
K
---
D
P
-
V
G
L
Y
V
S
G
G
N
T
Q
V
L
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
E
---------
K
Y
I
E
L
P
Y
A
V
K
---
G
M
D
L
S
F
S
G
L
L
T
---
E
A
I
R
K
Y
---
R
S
G
K
Y
R
V
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
H
T
E
K
-----
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
IMT
E
D
R
--
G
---
I
---
K
---
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
-
G
I
S
-
F
-
R
L
E
E
T
-
I
V
K
Q
K
F
R
T
D
E
-----
6
PsiBlast_PDB
86.14
29%
-117
- C2 -
3WUH
2
QRI7_YEAST
A:
[11-369]
---
V
L
A
I
E
T
S
C
D
D
T
C
V
S
V
L
D
R
F
S
K
S
A
A
P
--
N
V
L
A
N
-
L
K
-
D
T
LD--------
K
A
H
I
H
H
Q
A
R
I
G
P
L
T
E
R
A
L
I
E
S
N
A
R
E
-
G
I
D
L
I
C
V
T
R
G
P
G
M
P
G
S
L
S
G
G
L
D
F
A
K
G
L
A
V
A
W
N
K
P
L
I
G
V
H
H
M
L
G
H
L
L
I
P
R
M
G
-
T
---
N
G
K
VPQ
F
P
F
V
S
L
L
V
S
G
G
H
T
T
F
V
L
S
R
A
I
D
D
H
E
I
L
C
D
T
I
D
I
A
V
G
D
S
L
D
K
C
G
R
E
L
G
--
F
K
G
T
M
I
A
R
E
M
E
K
F
I
N
Q
D
INDQDF
A
L
K
L
E
M
P
-----
R
N
M
L
S
F
S
F
S
A
F
I
T
A
L
R
T
N
L
T
K
L
GKT--
P
E
R
E
I
R
S
I
A
Y
Q
V
Q
E
S
V
F
D
H
I
I
N
K
L
K
H
V
L
K
S
Q
P
E
K
F
K
N
V
R
E
F
V
C
S
G
G
V
S
S
N
Q
R
L
R
T
K
L
E
---
T
E
L
------
F
---
N
---
F
Y
Y
P
P
M
D
L
C
S
D
N
S
I
M
I
G
W
A
G
I
E
I
W
E
S
L
R
L
V
-
S
-
D
L
D
I
C
-
P
I
R
Q
W
P
L
N
D
L
-----