@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0235: (2015-12-13 )
MLEIKNLNCVLNSHFSLQNINISLSYSERVAIVGESGSGKSSIANLVMRLNPRFKPHNGEILFETTNLLKESEAFMQHLRGNIIAYIAQDPLSSLNPLHKIGKQMSEAYFLHHKNASQVLLKEQVLNAMKQVQLDEKFLDRYPYELSGGQRQRVCIAMGIINAPKLLICDEPTTALDAQIQNQILDLLKQLSVEKNIALLFISHDLKAVKRLADRVYVLKKGEIVETNLTKELFNDPKHEYSKLLIQASNLPAKNLKALDETLLEVKDFSVYYLQKRFFRPSLKKPLIASVDFSLKAKENIGIIGESGSGKSSLALGLLKLALNSGEEKILGQSVGLLNSKAFKPYRKILQMVFQDPYASLNPRLSIQSILIEALRFAYPKASQQEWHHLAELCLEEVCLNPELLNFYAYELSGGERQRVAIARAIALKPRIILLDEPTSALDKSIQKSVLELLLNLQEKQDLSYLFISHDLDVIKAFCDRVLVVSEGKIVETGAIEEVFDNPKHAYTKRLLESRL
Atome Classification :
(24 SA)
-.........10.----.......20........30........40........-50........60........70.......-----.80........-90........100.......110.....--..120......---.130...-....140.......150.......160.--......170.......180.......190.......200.......210.......------220.....-..230.......240........-----250.--......260.......270.......280.......290.......300.......310..--.....-320-.-----......330-----------....-.....340-.....--------..350.......360---------------..----------------------------------------------....-.-..370.....----------.----------.380-----------.........390.......400..-.....410.......420.......430-.........440.......450.......460.......470.......480...------....490.......500.......510....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
L
E
IK
N
L
N
C
V
LN----SH
F
S
L
Q
N
I
N
I
S
L
SYS
E
R
V
A
I
V
GESGSG
K
S
S
I
A
N
L
V
M
R-LNPRFKPHN
G
E
I
L
F
E
T
T
N
L
L
K
E
S
E
A
F
M
Q
H
-----LRG
N
I
I
A
Y
IAQ-DP
L
S
S
L
N
P
L
H
K
I
G
K
Q
M
S
E
A
Y
F
L
HHK
N
A
S
--
Q
V
L
L
K
E
Q
V
L
N
A
---
M
K
Q
V
Q
L
D
-
E
K
F
L
D
RYPYELSGGQ
R
Q
R
V
C
I
A
MGIINA--
P
K
L
L
I
CDEPT
T
A
L
D
A
Q
I
Q
N
Q
I
L
D
L
L
K
Q
LSVEK
N
I
A
L
L
F
ISH
D
L
K
A
V
K
R
L
A
D
R
V
Y
V
L
------KKG
E
I
V
E
T
-
N
L
T
K
E
L
FND
P
K
H
E
Y
-
S
K
L
L
I
QAS-----NLP
A
--
K
N
L
K
A
L
D
E
T
L
L
E
VKD
F
S
V
Y
Y
L
Q
K
R
FFRPSLKK
P
L
I
A
SV
D
F
S
L
K
AKENI
G
I
I
GESGSG
K
S
S
L
--
A
L
G
L
L
-
K
L
A
-L-----NS
G
E
E
K
I
-------------
L
G
Q
S
-VGLLN
S
K
A
-
F
K
P
Y
R
--------
K
I
L
Q
M
V
F
QDPYAS-----------------LN----------------------------------------------PR
L
S
-
I
-
Q
S
I
L
I
E
A
L
R
F
----------A----------YP-------------KA
S
Q
Q
E
W
H
H
L
A
E
L
C
L
E
E
VCL
N
P
E
L
-
L
N
F
Y
A
Y
ELSGGE
R
Q
R
V
A
I
A
R
A
IALK
P
---
R
I
I
L
LDE
P
T
S
A
L
D
K
S
I
Q
K
S
V
L
E
L
L
L
N
L
Q
E
KQD
L
S
Y
L
F
ISH
D
L
D
V
I
K
A
F
CD
R
V
L
V
V
------SE
G
K
I
V
ETG
A
I
E
E
V
FDN
P
K
H
A
Y
T
K
R
L
L
E
SRL
95
HHSearch
74.80
20%
-75
- C- -
2IW3
7
EF3A_YEAST
A:
[440-979]
------
E
F
S
L
A
Y
G
----
A
K
I
L
L
N
K
T
Q
L
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
-
G
---------
Q
V
--
D
G
F
P
T
Q
---------------
E
E
C
R
T
V
Y
V
E
H
-
D
I
D
G
-
T
H
S
D
T
S
V
L
D
F
V
F
E
S
----
G
--
V
-----
G
T
K
E
A
I
K
D
K
---
L
I
E
F
G
F
T
-
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
--
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
K
A
Y
E
E
L
S
N
T
D
L
E
F
K
F
P
E
P
G
YL
E
G
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P
G
T
-------
S
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
--
I
N
V
L
T
-
G
E
L
-
L
P----
T
S
G
E
V
Y
T
-------------
H
E
N
C
R
I
A
Y
I
K
Q
H
A
-
F
A
H
I
E
SHLDKT
P
S
E
Y
I
Q
W
R
F
Q
T
G
E
D
R
ETMDRANRQ--------
I
N
END
A
E
A
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
----------
C
S
F
L
-
L
-
G
E
N
I
G
M
K
S
E
R
W
V
P
M
M
SVD
N
A
W
I
P
RGELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
G
Q
F
R
P
L
T
R
K
E
I
E
E
H
C
S
M
L
G
L
D
P
E
I
V
S
H
S
R
I
R
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
---
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
A
L
S
K
A
L
K
E
F
----
E
G
G
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
------
K
D
G
R
M
T
P
S
-----------------------
4
PsiBlast_PDB
71.88
32%
-100
- C3 -
3TUZ
1
METN_ECOLI
C:
[30-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
IR
C
V
N
L
L
-
E
R
P
-------
T
E
G
S
V
L
V
-------------
D
G
Q
E
-
L
T
T
L
S
E
S
E
-
L
T
K
A
R
--------
R
Q
I
G
M
I
F
Q
H
-
F
N
L
-----------------
L
S
----------------------------------------------
S
R
T
V
-
F
-
G
N
V
---
A
L
P
L
----------
E
----------
L
D
-------------
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
--
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
---
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
------
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
3
PsiBlast_PDB
71.57
32%
-90
- C3 -
3TUI
1
METN_ECOLI
C:
[30-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
IR
C
V
N
L
L
-
E
R
P
-------
T
E
G
S
V
L
V
-------------
D
G
Q
E
-
L
T
T
L
S
E
S
E
-
L
T
K
A
R
--------
R
Q
I
G
M
I
F
Q
H
-
F
N
L
-----------------
L
S
----------------------------------------------
S
R
T
V
-
F
-
G
N
V
---
A
L
P
L
----------
E
----------
L
D
-------------
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
--
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
---
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
------
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
23
PsiBlast_CBE
71.20
32%
-92
- C3 -
3TUZ
1
METN_ECOLI
D:
[30-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
IR
C
V
N
L
L
-
E
R
P
-------
T
E
G
S
V
L
V
-------------
D
G
Q
E
-
L
T
T
L
S
E
S
E
-
L
T
K
A
R
--------
R
Q
I
G
M
I
F
Q
H
-
F
N
L
-----------------
L
S
----------------------------------------------
S
R
T
V
-
F
-
G
N
V
---
A
L
P
L
----------
E
----------
L
D
-------------
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
--
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
---
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
------
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
22
PsiBlast_CBE
70.84
32%
-92
- C3 -
3TUZ
1
METN_ECOLI
G:
[30-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
IR
C
V
N
L
L
-
E
R
P
-------
T
E
G
S
V
L
V
-------------
D
G
Q
E
-
L
T
T
L
S
E
S
E
-
L
T
K
A
R
--------
R
Q
I
G
M
I
F
Q
H
-
F
N
L
-----------------
L
S
----------------------------------------------
S
R
T
V
-
F
-
G
N
V
---
A
L
P
L
----------
E
----------
L
D
-------------
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
--
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
---
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
------
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
26
PsiBlast_CBE
70.70
32%
-88
- C3 -
3TUI
1
METN_ECOLI
D:
[30-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
IR
C
V
N
L
L
-
E
R
P
-------
T
E
G
S
V
L
V
-------------
D
G
Q
E
-
L
T
T
L
S
E
S
E
-
L
T
K
A
R
--------
R
Q
I
G
M
I
F
Q
H
-
F
N
L
-----------------
L
S
----------------------------------------------
S
R
T
V
-
F
-
G
N
V
---
A
L
P
L
----------
E
----------
L
D
-------------
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
--
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
---
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
------
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
25
PsiBlast_CBE
70.45
32%
-91
- C3 -
3TUI
1
METN_ECOLI
G:
[30-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
IR
C
V
N
L
L
-
E
R
P
-------
T
E
G
S
V
L
V
-------------
D
G
Q
E
-
L
T
T
L
S
E
S
E
-
L
T
K
A
R
--------
R
Q
I
G
M
I
F
Q
H
-
F
N
L
-----------------
L
S
----------------------------------------------
S
R
T
V
-
F
-
G
N
V
---
A
L
P
L
----------
E
----------
L
D
-------------
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
--
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
---
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
------
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
24
PsiBlast_CBE
69.81
32%
-95
- C3 -
3TUI
1
METN_ECOLI
H:
[30-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
IR
C
V
N
L
L
-
E
R
P
-------
T
E
G
S
V
L
V
-------------
D
G
Q
E
-
L
T
T
L
S
E
S
E
-
L
T
K
A
R
--------
R
Q
I
G
M
I
F
Q
H
-
F
N
L
-----------------
L
S
----------------------------------------------
S
R
T
V
-
F
-
G
N
V
---
A
L
P
L
----------
E
----------
L
D
-------------
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
--
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
---
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
------
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
120
Fugue
69.09
26%
-83
- C3 -
3TUZ
3
METN_ECOLI
H:
[23-362]
H
M
I
K
L
S
N
I
T
K
V
F
H
QGTR
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
-
L
E
---
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
-----
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
------
N
T
P
--
K
D
E
V
K
R
R
V
T
E
L
---
L
S
L
V
G
L
G
-
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
--
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
------
S
N
G
E
L
I
E
Q
-
D
T
V
S
E
V
F
S
H
P
K
T
P
L
-
A
Q
K
F
I
Q
S
T
-----
L
H
L
D
--
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
--
G
I
M
L
T
-
E
M
H
---------
G
T
Q
Q
D
-------------
T
Q
A
A
-
I
A
W
L
Q
E
H
H
-
V
K
V
E
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
67.94
32%
-90
- C3 -
3TUZ
1
METN_ECOLI
H:
[30-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
IR
C
V
N
L
L
-
E
R
P
-------
T
E
G
S
V
L
V
-------------
D
G
Q
E
-
L
T
T
L
S
E
S
E
-
L
T
K
A
R
--------
R
Q
I
G
M
I
F
Q
H
-
F
N
L
-----------------
L
S
----------------------------------------------
S
R
T
V
-
F
-
G
N
V
---
A
L
P
L
----------
E
----------
L
D
-------------
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
--
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
---
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
------
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
14
PsiBlast_PDB
67.78
33%
-122
- C3 -
4YMT
-
?
J:
[16-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
---
L
R
C
I
-
N
L
L
-
E
-----
E
P
T
K
G
E
V
-------------
F
I
D
G
-
V
K
I
N
N
G
K
V
N
I
N
K
V
R
--------
Q
K
V
G
M
V
F
Q
--
H
F
N
-----------------
L
F
----------------------------------------------
P
H
L
T
A
I
-
E
N
I
T
L
A
P
V
K
V
----------
K
-------------------------
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
-
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
---
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
------
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
1
PsiBlast_PDB
67.31
37%
-97
- C3 -
4FWI
3
?
B:
[37-257]
----------------------------------
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
T
K
T
L
P
P
N
G
R
I
L
S
G
R
V
L
Y
K
G
K
D
L
L
T
M
R
E
E
E
L
R
K
-----
I
R
W
K
E
I
A
L
V
P
Q
-
A
A
Q
Q
S
L
N
P
T
M
K
V
I
E
H
F
K
D
T
V
E
A
H
G
V
R
W
S
--
H
S
E
L
I
E
K
A
S
E
K
---
L
R
M
V
R
L
N
P
E
A
V
L
N
S
Y
P
L
Q
L
S
G
G
M
K
Q
R
V
L
I
A
L
A
L
L
L
D
--
P
V
V
L
I
L
D
E
P
T
S
A
L
D
V
L
T
Q
A
H
I
I
Q
L
L
K
E
L
K
K
M
L
K
I
T
L
I
F
V
T
H
D
I
A
V
A
A
E
L
A
D
K
V
A
V
I
------
Y
G
G
N
L
V
E
Y
-
N
S
T
F
Q
I
F
K
N
P
L
H
P
Y
-
T
R
G
L
I
N
S
I
-----
M
P
I
P
--
G
D
P
P
S
L
L
N
P
P
S
G
C
R
F
H
P
R
C
E
Y
A
M
E
I
C
K
K
E
K
P
K
W
I
R
L
D
G
E
A
H
V
A
C
H
L
Y
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
67.23
33%
-119
- C3 -
4YMU
2
?
A:
[16-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
---
L
R
C
I
-
N
L
L
-
E
-----
E
P
T
K
G
E
V
-------------
F
I
D
G
-
V
K
I
N
N
G
K
V
N
I
N
K
V
R
--------
Q
K
V
G
M
V
F
Q
--
H
F
N
-----------------
L
F
----------------------------------------------
P
H
L
T
A
I
-
E
N
I
T
L
A
P
V
K
V
----------
K
-------------------------
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
-
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
---
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
------
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
13
PsiBlast_PDB
67.23
33%
-123
- C3 -
4YMS
-
?
J:
[16-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
---
L
R
C
I
-
N
L
L
-
E
-----
E
P
T
K
G
E
V
-------------
F
I
D
G
-
V
K
I
N
N
G
K
V
N
I
N
K
V
R
--------
Q
K
V
G
M
V
F
Q
--
H
F
N
-----------------
L
F
----------------------------------------------
P
H
L
T
A
I
-
E
N
I
T
L
A
P
V
K
V
----------
K
-------------------------
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
-
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
---
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
------
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
107
HHSearch
67.18
28%
-104
- C3 -
1Z47
1
?
A:
[11-247]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
--------
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
--
L
R
L
I
A
-
G
L
E
-
R
P----
T
K
G
D
V
W
I
-------------
G
G
K
R
-
V
T
D
L
P
------
P
Q
K
--------
R
N
V
G
L
V
F
Q
N
Y
A
-------------------
L
F
----------------------------------------------
Q
H
M
T
-
V
-
Y
D
N
V
S
F
G
L
R
E
----------
K
----------
R
---------------
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
-
S
Y
-
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
---
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
------
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
N
15
PsiBlast_PDB
66.93
33%
-119
- C3 -
4YMU
2
?
J:
[16-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
---
L
R
C
I
-
N
L
L
-
E
-----
E
P
T
K
G
E
V
-------------
F
I
D
G
-
V
K
I
N
N
G
K
V
N
I
N
K
V
R
--------
Q
K
V
G
M
V
F
Q
--
H
F
N
-----------------
L
F
----------------------------------------------
P
H
L
T
A
I
-
E
N
I
T
L
A
P
V
K
V
----------
K
-------------------------
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
-
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
---
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
------
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
101
HHSearch
66.68
24%
-61
- C4 -
2VF7
3
?
A:
[362-839]
---------------------------------------------------------------------------------------------------------------------------------------------
V
---
L
L
H
L
G
L
G
-
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
LF
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
-
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
R
-
A
D
W
L
V
D
V
G
PEAGE
K
G
G
E
I
L
Y
S
-
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
-
G
Q
Y
L
F
A
D
R
-----
H
-
T
E
--
P
H
T
P
R
E
P
A
G
W
L
E
L
N
G
V
T
--------------
R
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
--
V
S
Q
A
L
V
D
A
L
-
A
A
H
F
GQ--
G
S
A
R
L
G
G
DLAQIT
R
L
V
R
V
D
Q
K
P
-
I
G
R
T
P
R
----
S
N
M
A
--------
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
GYNAGRFS
F
N
VKGGRCEHCQGEGWVMVELLFL
P
S
V
Y
A
P
CPVCHGTRYN
A
E
T
L
E
VEY
R
G
K
N
-
I
-
A
D
V
L
A
L
T
V
D
E
----------
A
----------
H
D
-------------
F
F
A
D
E
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
-
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
RGG
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
PGAGE
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
-
S
V
T
A
P
Y
L
R
A
A
L
16
PsiBlast_PDB
66.46
33%
-120
- C3 -
4YMV
1
?
J:
[16-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
---
L
R
C
I
-
N
L
L
-
E
-----
E
P
T
K
G
E
V
-------------
F
I
D
G
-
V
K
I
N
N
G
K
V
N
I
N
K
V
R
--------
Q
K
V
G
M
V
F
Q
--
H
F
N
-----------------
L
F
----------------------------------------------
P
H
L
T
A
I
-
E
N
I
T
L
A
P
V
K
V
----------
K
-------------------------
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
-
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
---
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
------
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
2
PsiBlast_PDB
65.14
32%
-87
- C3 -
3DHW
-
METN_ECOLI
C:
[7-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
IR
C
V
N
L
L
-
E
R
P
-------
T
E
G
S
V
L
V
-------------
D
G
Q
E
-
L
T
T
L
S
E
S
E
-
L
T
K
A
R
--------
R
Q
I
G
M
I
F
Q
H
-
F
N
L
-----------------
L
S
----------------------------------------------
S
R
T
V
-
F
-
G
N
V
---
A
L
P
L
----------
E
----------
L
D
-------------
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
--
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
---
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
------
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
17
PsiBlast_PDB
65.09
33%
-121
- C3 -
4YMW
-
?
J:
[16-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
---
L
R
C
I
-
N
L
L
-
E
-----
E
P
T
K
G
E
V
-------------
F
I
D
G
-
V
K
I
N
N
G
K
V
N
I
N
K
V
R
--------
Q
K
V
G
M
V
F
Q
--
H
F
N
-----------------
L
F
----------------------------------------------
P
H
L
T
A
I
-
E
N
I
T
L
A
P
V
K
V
----------
K
-------------------------
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
-
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
---
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
------
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
32
PsiBlast_CBE
64.63
33%
-120
- C3 -
4YMV
1
?
A:
[16-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
---
L
R
C
I
-
N
L
L
-
E
-----
E
P
T
K
G
E
V
-------------
F
I
D
G
-
V
K
I
N
N
G
K
V
N
I
N
K
V
R
--------
Q
K
V
G
M
V
F
Q
--
H
F
N
-----------------
L
F
----------------------------------------------
P
H
L
T
A
I
-
E
N
I
T
L
A
P
V
K
V
----------
K
-------------------------
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
-
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
---
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
------
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
10
PsiBlast_PDB
62.47
32%
-99
- C3 -
4U00
3
?
A:
[19-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
--
I
R
T
I
N
-
R
L
E
D
F
-----
Q
E
G
E
V
V
V
-------------
D
G
L
S
-
V
K
--
D
D
R
A
-
L
R
E
I
R
--------
R
E
V
G
M
V
F
Q
Q
--
F
N
-----------------
L
F
----------------------------------------------
P
H
M
T
-
V
L
E
N
V
T
L
A
P
M
R
V
----------
R
R---------
W
P
-------------
R
E
K
A
E
K
---
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
-
R
K
-
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
---
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
------
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
70
PsiBlast_CBE
45.17
31%
-85
- C3 -
4S0F
2
?
A:
[505-725]
---------------------
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
-
F
---
Y
S
P
E
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
---
L
E
L
-----
I
R
K
K
I
-
A
F
V
S
Q
-
D
-------
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
N
E
N
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
--
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
--
E
D
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
-
C
D
K
I
Y
L
L
------
K
D
G
E
I
V
E
S
-
G
S
H
T
E
L
I
A
-
L
K
G
C
Y
-
F
K
M
W
K
Q
T
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
43.82
31%
-81
- C3 -
2FF7
1
A:
[25-241]
---------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
-
F
---
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
GVV
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
P
----
G
M
S
V
E
K
V
I
Y
-----
A
A
--
K
L
A
G
A
H
D
F
I
S
E
---
L
R
E
G
Y
---
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
--
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
------
E
K
G
K
I
V
E
Q
-
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
-
S
Y
L
Y
Q
L
Q
S
-----
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------