@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1020: (2015-12-20 )
MALLFTGACGYIGSHTARVFLEKTKENIIIIDDLSTGFLEHIKALERYYPNRVAFIQANLNETQKLDAFLNKQQLKDPIEAVLHFGAKISVEESMRLPLEYYTNNTLNTLGLVKLCLKHAIKRFIFSSTAVVYGESGSSLSEESPLNPINPYGASKMMSERILLDASKVADFKCVILRYFNVAGACMHNDYTTPYTLGQRTLNATHLIKIACECAVGKRKKMGIFGTNYPTRDGTCIRDYIHVDDLANAHLASYHTLLEKNKSEIYNVGYNQGHSVKEVIEKVKEISNKDFLVEILDKRQGDPASLIANNSKILQNTPFKPLYNNLDTIIKSALSWEEHLLKFQ
Atome Classification :
(22 SA)
-.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130..-..-.-----..140..-..-.-..150.......160.......--170-........180.......190.......200-.-.-.....210.......220.......230.......240.......250.......260.----......270.......280.......290.......300.......310.......320.......330.......340..--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
A
L
L
F
TGACGYIG
S
H
T
A
R
V
F
L
E
KTKE
N
I
I
I
I
DDL
S
T
G
F
L
E
H
I
K
A
L
E
R
YYPN
R
V
A
F
I
QANLN
E
T
Q
K
L
D
A
F
L
N
K
Q
Q
L
K
D
P
I
E
A
V
L
HFG
A
K
I
S
V
E
ESMRL
P
L
E
YYTNNT
L
N
T
L
G
L
V
K
L
C
L
K
H
A
I
K
R
F
I
FSS
T
A
V
V
YG-ES-G-----SSLSEES-PL-N-PINPY
G
A
S
K
M
M
S
E
R
I
LL
D
A
S
KV--A
D
--
F
K
C
V
I
L
R
Y
F
N
V
A
G
A
C
MHNDYTTPY
T
L
G
QRTL-
N
-
A
-
T
H
L
I
K
I
A
C
ECAVGKRKKM
G
I
FGTNYPTRDG
T
C
I
R
D
Y
I
H
V
D
D
L
A
N
A
H
L
A
S
Y
H
T
L
L
E
K
N
K
S
----
E
I
Y
NVGYNQGH
S
V
K
E
V
I
E
K
V
K
E
ISN
K
D
F
L
V
E
I
L
D
KRQGD
P
A
S
L
IANN
S
K
ILQNTPF
K
P
L
Y
N
N
L
D
T
I
I
K
S
A
L
S
W
E
E
H
L
LKFQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
94.63
38%
-104
- C1 -
2C20
2
?
A:
[2-326]
-
N
S
I
L
I
C
G
G
A
G
Y
I
G
S
H
A
V
K
K
L
V
D
-
E
G
L
S
V
V
V
V
D
N
L
Q
T
G
H
-
E
D
A
------
I
T
E
G
A
K
F
Y
N
G
D
L
R
D
K
A
F
L
R
D
V
---
F
T
Q
E
-
N
I
E
A
V
M
H
F
A
A
D
S
L
V
G
V
S
M
E
K
P
L
Q
Y
Y
N
N
N
V
Y
G
A
L
C
L
L
E
V
M
D
E
F
K
V
D
K
F
I
F
S
S
T
A
A
T
Y
G
-
E
V
D
V
-----
D
L
I
T
E
E
T
-
M
T
-
N
-
P
T
N
T
Y
G
E
T
K
L
A
I
E
K
M
L
H
W
Y
S
Q
A
--
S
N
--
L
R
Y
K
I
F
R
Y
F
N
V
A
G
A
T
P
N
G
------
I
I
G
E
D
H
R
-
P
-
E
-
T
H
L
I
P
L
V
L
Q
V
A
L
G
Q
R
E
K
I
M
M
F
G
D
D
Y
N
T
P
D
G
T
C
I
R
D
Y
I
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
Q
N
G
G
E
S
----
D
F
Y
N
L
G
N
G
N
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
H
E
I
P
A
E
V
A
P
R
R
A
G
D
P
A
R
L
V
A
S
S
Q
K
A
K
E
K
L
G
W
D
P
R
Y
V
N
V
K
T
I
I
E
H
A
W
N
W
H
Q
K
Q
P
N
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
91.15
34%
-98
- C1 -
1UDC
8
GALE_ECOLI
A:
[1-329]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
-
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
S
K
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
----
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
-
D
Q
-
P
-----
K
I
P
Y
V
E
S
F
P
T
-
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-
P
D
--
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
------
M
G
E
D
P
Q
-
G
I
P
-
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
G
V
----
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
-
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
90.83
35%
-96
- C1 -
3ENK
2
?
A:
[6-337]
-
G
T
I
L
V
T
G
G
A
G
Y
I
G
S
H
T
A
V
E
L
L
A
-
H
G
Y
D
V
V
I
A
D
N
L
V
N
S
K
R
E
A
I
A
R
I
E
K
I
T
G
K
T
P
A
F
H
E
T
D
V
S
D
E
R
A
L
A
R
I
---
F
D
A
H
-
P
I
T
A
A
I
H
F
A
A
L
K
A
V
G
E
S
V
A
K
P
I
E
Y
Y
R
N
N
L
D
S
L
L
S
L
L
R
V
M
R
E
R
A
V
K
R
I
V
F
S
S
S
A
T
V
Y
G
-
V
P
E
R
-----
S
P
I
D
E
T
F
-
P
L
-
S
-
A
T
N
P
Y
G
Q
T
K
L
M
A
E
Q
I
L
R
D
V
E
A
A
D-
P
S
--
W
R
V
A
T
L
R
Y
F
N
P
V
G
A
H
E
S
G
------
L
I
G
E
D
P
A
G
I
-
P
-
N
N
L
M
P
Y
V
A
Q
V
A
V
G
K
L
E
K
L
R
V
F
G
S
D
Y
P
T
P
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
R
G
H
I
A
A
L
D
A
L
E
R
R
D
A
S
----
L
T
V
N
L
G
T
G
R
G
Y
S
V
L
E
V
V
R
A
F
E
K
A
S
G
R
A
V
P
Y
E
L
V
A
R
R
P
G
D
V
A
E
C
Y
A
N
P
A
A
A
A
E
T
I
G
W
K
A
E
R
-
D
L
E
R
M
C
A
D
H
W
R
W
Q
E
N
N
P
R
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
90.69
34%
-96
- C1 -
3ENK
2
?
A:
[8-335]
---
I
L
V
T
G
G
A
G
Y
I
G
S
H
T
A
-
V
E
L
L
A
H
G
Y
D
V
V
I
A
D
N
L
V
N
S
K
R
E
A
I
A
R
I
E
K
I
T
G
K
T
P
A
F
H
E
T
D
V
S
D
E
R
A
L
A
R
I
F
D
A
H
----
P
I
T
A
A
I
H
F
A
A
L
K
A
V
G
E
S
V
A
K
P
I
E
Y
Y
R
N
N
L
D
S
L
L
S
L
L
R
V
M
R
E
R
A
V
K
R
I
V
F
S
S
S
A
T
V
Y
G
V
P
E
-
R
-----
S
P
I
D
E
T
F
-
P
L
-
S
-
A
T
N
P
Y
G
Q
T
K
L
M
A
E
Q
I
L
R
D
V
-
E
A
--
A
D
PS
W
R
V
A
T
L
R
Y
F
N
P
V
G
A
H
E
S
G
------
L
I
G
E
D
P
A
-
G
I
P
-
N
N
L
M
P
Y
V
A
Q
V
A
V
G
K
L
E
K
L
R
V
F
G
S
D
Y
P
T
P
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
R
G
H
I
A
A
L
D
A
L
E
R
R
D
A
S
----
L
T
V
N
L
G
T
G
R
G
Y
S
V
L
E
V
V
R
A
F
E
K
A
S
G
R
A
V
P
Y
E
L
V
A
R
R
P
G
D
V
A
E
C
Y
A
N
P
A
A
A
A
E
T
I
G
W
K
-
A
E
R
D
L
E
R
M
C
A
D
H
W
R
W
Q
E
N
N
P
R
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
90.65
34%
-99
- C1 -
1XEL
5
GALE_ECOLI
A:
[1-329]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
-
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
S
K
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
----
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
-
D
N
-
P
-----
K
I
P
Y
V
E
S
F
P
T
-
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-
P
D
--
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
------
M
G
E
D
P
Q
-
G
I
P
-
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
G
V
----
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
-
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
90.57
34%
-98
- C1 -
1NAH
4
GALE_ECOLI
A:
[1-329]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
-
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
S
K
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
----
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
-
D
N
-
P
-----
K
I
P
Y
V
E
S
F
P
T
-
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-
P
D
--
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
------
M
G
E
D
P
Q
-
G
I
P
-
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
G
V
----
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
-
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
90.53
34%
-100
- C1 -
2UDP
2
GALE_ECOLI
B:
[1-329]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
-
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
S
K
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
----
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
-
D
Q
-
P
-----
K
I
P
Y
V
E
S
F
P
T
-
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q-
P
D
--
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
------
M
G
E
D
P
Q
-
G
I
P
-
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
G
V
----
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
-
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
90.20
34%
-97
- C1 -
1UDB
6
GALE_ECOLI
A:
[1-329]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
-
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
S
K
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
----
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
-
D
N
-
P
-----
K
I
P
Y
V
E
S
F
P
T
-
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-
P
D
--
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
------
M
G
E
D
P
Q
-
G
I
P
-
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
G
V
----
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
-
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
90.16
34%
-101
- C1 -
1LRJ
5
GALE_ECOLI
A:
[1-329]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
-
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
S
K
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
----
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
-
D
N
-
P
-----
K
I
P
Y
V
E
S
F
P
T
-
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-
P
D
--
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
------
M
G
E
D
P
Q
-
G
I
P
-
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
G
V
----
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
-
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
89.90
34%
-94
- C1 -
3ENK
2
?
B:
[8-335]
---
I
L
V
T
G
G
A
G
Y
I
G
S
H
T
A
-
V
E
L
L
A
H
G
Y
D
V
V
I
A
D
N
L
V
N
S
K
R
E
A
I
A
R
I
E
K
I
T
G
K
T
P
A
F
H
E
T
D
V
S
D
E
R
A
L
A
R
I
F
D
A
H
----
P
I
T
A
A
I
H
F
A
A
L
K
A
V
G
E
S
V
A
K
P
I
E
Y
Y
R
N
N
L
D
S
L
L
S
L
L
R
V
M
R
E
R
A
V
K
R
I
V
F
S
S
S
A
T
V
Y
G
V
P
E
-
R
-----
S
P
I
D
E
T
F
-
P
L
-
S
-
A
T
N
P
Y
G
Q
T
K
L
M
A
E
Q
I
L
R
D
V
-
E
A
--
A
D
PS
W
R
V
A
T
L
R
Y
F
N
P
V
G
A
H
E
S
G
------
L
I
G
E
D
P
A
-
G
I
P
-
N
N
L
M
P
Y
V
A
Q
V
A
V
G
K
L
E
K
L
R
V
F
G
S
D
Y
P
T
P
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
R
G
H
I
A
A
L
D
A
L
E
R
R
D
A
S
----
L
T
V
N
L
G
T
G
R
G
Y
S
V
L
E
V
V
R
A
F
E
K
A
S
G
R
A
V
P
Y
E
L
V
A
R
R
P
G
D
V
A
E
C
Y
A
N
P
A
A
A
A
E
T
I
G
W
K
-
A
E
R
D
L
E
R
M
C
A
D
H
W
R
W
Q
E
N
N
P
R
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
89.89
34%
-98
- C1 -
1KVR
7
GALE_ECOLI
A:
[1-329]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
-
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
S
K
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
----
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
G
-
D
Q
-
P
-----
K
I
P
Y
V
E
S
F
P
T
-
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-
P
D
--
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
------
M
G
E
D
P
Q
-
G
I
P
-
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
G
V
----
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
-
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
89.69
34%
-98
- C1 -
2UDP
4
GALE_ECOLI
A:
[1-329]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
-
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
S
K
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
----
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
-
D
Q
-
P
-----
K
I
P
Y
V
E
S
F
P
T
-
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-
P
D
--
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
------
M
G
E
D
P
Q
-
G
I
P
-
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
G
V
----
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
-
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
89.59
34%
-97
- C1 -
1KVQ
4
GALE_ECOLI
A:
[1-329]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
-
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
S
K
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
----
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
G
-
D
N
-
P
-----
K
I
P
Y
V
E
S
F
P
T
-
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-
P
D
--
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
------
M
G
E
D
P
Q
-
G
I
P
-
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
G
V
----
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
-
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
89.49
34%
-99
- C1 -
1NAI
4
GALE_ECOLI
A:
[1-329]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
-
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
S
K
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
----
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
-
D
N
-
P
-----
K
I
P
Y
V
E
S
F
P
T
-
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-
P
D
--
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
------
M
G
E
D
P
Q
-
G
I
P
-
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
G
V
----
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
-
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
89.46
34%
-96
- C1 -
1A9Y
4
GALE_ECOLI
A:
[1-329]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
-
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
S
K
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
----
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
G
-
D
Q
-
P
-----
K
I
P
Y
V
E
S
F
P
T
-
G
T
P
Q
S
P
F
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-
P
D
--
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
------
M
G
E
D
P
Q
-
G
I
P
-
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
G
V
----
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
-
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
89.06
34%
-99
- C1 -
1LRK
5
GALE_ECOLI
A:
[1-329]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
-
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
S
K
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
----
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
-
D
N
-
P
-----
K
I
P
Y
V
E
S
F
P
T
-
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-
P
D
--
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
------
M
G
E
D
P
Q
-
G
I
P
-
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
G
V
----
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
C
W
A
D
A
S
K
A
D
R
E
L
N
W
R
-
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
88.92
34%
-98
- C1 -
1A9Z
5
GALE_ECOLI
A:
[1-329]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
-
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
S
K
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
----
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
G
-
D
N
-
P
-----
K
I
P
Y
V
E
S
F
P
T
-
G
T
P
Q
S
P
F
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-
P
D
--
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
------
M
G
E
D
P
Q
-
G
I
P
-
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
G
V
----
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
-
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
88.70
34%
-97
- C1 -
1KVU
6
GALE_ECOLI
A:
[1-329]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
-
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
S
K
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
----
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
-
D
Q
-
P
-----
K
I
P
Y
V
E
S
F
P
T
-
G
T
P
Q
S
P
F
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-
P
D
--
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
------
M
G
E
D
P
Q
-
G
I
P
-
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
G
V
----
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
-
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
88.55
34%
-96
- C1 -
1KVT
4
GALE_ECOLI
A:
[1-329]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
-
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
S
K
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
----
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
V
A
T
V
Y
G
-
D
N
-
P
-----
K
I
P
Y
V
E
S
F
P
T
-
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-
P
D
--
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
------
M
G
E
D
P
Q
-
G
I
P
-
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
G
V
----
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
-
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
87.65
34%
-95
- C1 -
1UDA
6
GALE_ECOLI
A:
[1-329]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
-
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
S
K
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
----
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
-
D
N
-
P
-----
K
I
P
Y
V
E
S
F
P
T
-
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-
P
D
--
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
------
M
G
E
D
P
Q
-
G
I
P
-
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
G
V
----
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
-
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
86.91
34%
-94
- C1 -
1UDB
7
GALE_ECOLI
A:
[1-334]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
-
N
G
H
D
V
I
I
L
D
N
L
C
N
S
K
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
---
L
H
D
H
-
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
-
D
N
P
K
-----
I
P
Y
V
E
S
F
-
P
T
G
T
-
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-
P
D
--
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
------
D
M
G
E
D
P
Q
G
I
-
P
-
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
K
P
G
V
----
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
-
T
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
85.91
33%
-90
- C1 -
1Z45
5
GAL10_YEAST
A:
[11-699]
S
K
I
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
V
E
L
I
E
N
-
G
Y
D
C
V
V
A
D
N
L
S
N
S
T
Y
D
S
V
A
R
L
E
V
L
T
K
H
H
I
P
F
Y
E
V
D
L
C
D
R
K
G
L
E
K
V
F
K
E
Y
----
K
I
D
S
V
I
H
F
A
G
L
K
A
V
G
E
S
T
Q
I
P
L
R
Y
Y
H
N
N
I
L
G
T
V
V
L
L
E
L
M
Q
Q
Y
N
V
S
K
F
V
F
S
S
S
A
T
V
Y
G
-
D
A
-
T
RFPNM
I
P
I
P
E
E
C
-
P
L
-
G
-
P
T
N
P
Y
G
H
T
K
Y
A
I
E
N
I
L
N
D
L
Y
N
S
D
K
K
S
--
W
K
F
A
I
L
R
Y
F
N
P
I
G
A
------
H
P
S
G
L
I
G
E
D
P
L
-
G
-
I
P
N
N
L
L
P
Y
M
A
Q
V
A
V
G
R
R
E
K
L
Y
I
F
R
------
D
G
T
P
I
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
Q
Y
L
E
A
Y
N
E
N
E
G
L
C
R
E
W
N
L
G
S
G
K
G
S
T
V
F
E
V
Y
H
A
F
C
K
A
S
G
I
D
L
P
Y
V
L
---------
N
L
T
A
K
P
D
R
A
K
R
E
L
K
W
Q
T
E
L
Q
-
V
E
D
S
C
K
D
L
W
K
W
T
T
E
N
P
F
G
Y
QLRG
V
E
A
R
F
SAEDMRYDA
R
F
V
T
I
GAGTR
F
Q
A
T
F
A
NLGASIV
D
L
K
V
NGQSV
V
L
G
Y
EN
E
E
G
Y
L
NPDSAYIGATIGRYANRISKG
K
F
S
L
CN
K
D
Y
Q
L
TVNNGVNANHSSIGSFHR
K
R
F
L
G
P
I
I
Q
NPSKD
V
F
T
A
E
Y
M
L
I
D
N
EKDTEFP
G
D
L
L
V
T
I
Q
Y
T
V
N
VAQK
S
L
E
I
V
Y
K
G
K
L
TAGE
A
T
P
I
N
L
T
N
H
S
Y
F
N
LNKPYGDTIEG
T
E
I
M
V
RSK
K
S
V
D
V
D
KNMIPTG
N
I
V
D
R
EIATFNSTK
P
T
V
L
G
PKNP
Q
F
D
C
C
F
V
VDENAKPSQINTLNNELTLI
V
K
A
F
H
PDSN
I
T
L
E
V
L
S
TEP
T
Y
Q
F
Y
TGDFLSAGYEARQ
G
F
A
I
E
P
G
RYIDAINQENWKDCVTLKNG
E
T
Y
G
S
K
I
V
Y
R
F
S