@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2050: (2016-03-31 )
MVQEYIRLRGARENNLQNISLDIPKRKITIFTGVSGSGKSSIVFETIATESQRQLNETYSAYLRNFLPKYTQPDADSIENLSTSVIIDQKRLGGNSRSTLGTITDINSILRLLFSRVGKPSIGTANLFSFNDPAGMCPDCHGVGQKVSVDLVKLLDPNKSLKEGAILFPTFSVDSWYWNSYAYSGFFDVNKKIKDYTDEEYDMLLHGKDIKVFLETPMGSMNATYEGLIPKFNRLYIQKEGEMSASTKKRVDKFTHIAPCTTCEGTRLSAQALSCKINGANIADFTAMQLDELKDTIARIDDPIATPMVKSVTERLQHLIDIGLGYMTLDRQTASLSGGESQRVKMIRHLNSSLTDLLYIFDEPSIGLHPRDVHRLNELLVKLRDKGNTILVVEHDPDVIKIADHVVDVGPHAGKHGGEIQFVGSYTDLLKSDTLTGQFLNRHLPINSKPRQPKGFLTTEKSSRFNLKNIQANIPKEVLTVITGVAGSGKSTLIHSVFLKEYPDAIVIDQSAAHANIRSNPATYTGIMDPIRKAFGKENDVSPSLFSYNSKGACENCKGLGFTTMDLAFMDSIRTPCEVCHGKRFQDSVLQYKLNGKSISDVLELTVSEALDFFTDKKILKKIEAMEEVGIGYVTLGQALSTLSGGECQRLKLANELHKKGSIYIMDEPTTGLHMSDIEHILTIIHTLVNKGNTVIVIEHNVDIIRNADWIIDLGPEGGSAGGQIIFEGAPLDLLENQQSLTAKYL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70...-----.....80--.........90........100.......110......--.120..---------------------------------------------------------------------------------------------..--.....130.......140.......150...-.-...--160.......170....--...180-.------....-----.-----..--190.......200.....---..210...-----------....220...---....230.......240.-.---------------------.....250.......260.......270.......--------280.....------------..290-.....-----....300..-----.-----------------....310...---....-------320.......----330.......340.......350..-.-....360.......370.......380.......390.......400........410.......420.......---430.---.-....--..440.--..----.----.----.--.---.-.-----450...-....460.----.----.....470.......480.......490......-----------------------------------.500--------------------..-----------------------.--....-..510.......---520.......530....-----...-----540----........550..-......560.......570.......580.......590.......600.......610....---..-.---620.......630.......640.......650.......660-.---........670.......680----.......690........700....-...710.......720.......730.......740....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
Q
E
Y
I
R
L
RGARENNL
Q
N
I
S
LDIPK
R
K
I
T
I
F
TGVSGSGK
S
S
I
V
F
E
TIA
T
E
S
Q
R
Q
L
N
E
T
Y
S
A
Y
L
R
N
F
L
P
KYTQPD-----
A
D
S
I
E
N---LS
T
S
V
I
I
D
Q
K
RLGGNSRS
T
L
G
T
I
T
D
I
N
S
I
L
R
L
L
F
S
RVG--KP--SI---------------------------------------------------------------------------------------------GT--
A
N
L
FSFNDPAGMCPDCHGVG
Q
K
V
S
V
D
L
V
K
LL-D-PNK--SLKE
G
A
I
L
F
P
T
FSV
D
S
W
--
Y
WN
S
Y
--
A
------YS
G
F
-----
F
-----DV--
N
K
K
IKDYTDEEY
D
M
L
L
HG---K
D
I
K
V
F
L
E-----------TPMGSMN
A
T
Y
---
E
G
LIPKF
N
R
L
Y
I
QKEGEM-S---------------------
A
S
T
K
K
R
V
D
K
FTHIAPCTTCEGT
R
L
S
A
Q
A
L
S
C
K
ING--------ANIA
D
F
T
A
------------
M
Q
L
---
D
E
L
K
D
-----
T
I
A
RIDDPI-----A-----------------
T
P
M
V
K
S
V
T
E
R
---
L
Q
H
L
-------
I
D
IGL
G
Y
M
T
L
----DRQTASLSGG
E
S
Q
R
V
K
M
I
R
H
L
N
S
S
L
-
T
-
D
L
L
Y
I
FDEPSIGLH
P
R
D
V
H
R
L
N
E
L
L
V
K
L
RDKG
N
T
I
L
V
V
EHDPD
V
I
K
-
I
A
D
H
V
V
DVGPHAGKHG
G
E
I
Q
F
V
G
S
Y
T
D
L
---
L
K-S---D-T
L
T
G
--
Q
F
L
--
N
--RH----L----P----I--N---S-K-----PRQPK
G
-
F
L
TTEKSS----R----FNL
K
N
IQAN
I
P
K
E
V
L
T
V
I
TGVAGSG
K
S
T
L
I
H
S
V
F
-----------------------------------
L
K
----------------------EY-----------------------P--
D
A
I
V
-
I
DQSAAHANIRS---NPATYT
G
I
M
D
P
I
R
K
AFG-----KEN-----DV-----SPSLFSYNSK-GA-CENCKGLGF
T
T
M
D
L
A
F
M
D
SIR
T
P
C
E
V
CHGK
R
F
Q
D
S
V
L
Q
Y
K
LNGK
S
I
S
D
V
L
E
L
T
V
S
E
A
L
D
F
F
T
D
---
K
K
-
I
---
L
K
K
I
E
A
M
E
E
VG
I
G
Y
V
T
L
G
Q
A
L
S
TLSGG
E
C
Q
R
L
K
L
A
N
E
LHKK---G---
S
I
Y
I
MDEPTTGL
H
M
S
D
I
E
H
I
L
----
T
I
I
H
T
L
VN-KG
N
T
V
I
V
I
EHNV
D
I
I
R-NA
D
W
I
I
D
LGPEGGSAG
G
Q
I
I
FEGA
P
L
D
L
LE
N
Q
Q
S
L
TAKYL
112
HHSearch
92.31
43%
-83
- C3 -
2R6F
5
?
A:
[21-952]
--
M
D
K
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
-----
V
D
A
I
E
G
---
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
--
R
P
--
I
C
PTHGIE
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
YPER
T
K
M
Q
I
L
A
PIDVVV
D
R
I
I
I
K
D
GI
A
A
R
L
A
D
S
L
E
T
A
L
K
L
ADG
K
V
V
V
DVIGEGE
L
L
F
S
EKHACPYCGFSIGE
L
E
--
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
D
L
D
L
V
I
-
P
N
D
E
L
--
T
L
K
E
H
A
I
A
P
W
E
P
----
Y
--
Y
P
Q
L
L
E
-
A
V
C
----
R
H
Y
G
-----
I
-----
P
M
--
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
---
S
G
G
E
P
I
Y
F
R
Y
T
N
DF-----
G
Q
V
R
E
Q
Y
I
A
F
---
E
G
V
I
P
N
V
----
E
R
R
Y
R
E
T
S
S
---------------------
D
Y
I
R
E
Q
M
E
K
Y
M
A
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Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
G
G
--------
K
H
I
G
E
V
T
A
------------
M
S
V
---
T
E
A
L
A
-----
F
F
D
G
L
E
L
T
E
K
E
A
Q
I
A
-----------------
R
L
I
L
R
E
I
R
D
R
---
L
G
F
L
-------
Q
N
V
G
L
D
Y
L
T
L
----
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
-
T
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
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D
T
M
L
-
A
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
---
M
N
-
D
---
P
N
S
L
T
G
--
Q
Y
L
--
S
--
G
K
----
K
----
F
----
I
PI
P
A--
E
-
R
-----
R
R
P
D
G
R
-
W
L
E
V
V
G
A
R
----
E
----
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
-----------------------------------
Y
K
----------------------
A
L
A
Q
K
LHRAK
A
K
P
G
EHRDIRGLEHL
D
--
K
V
I
D
-
I
D
Q
S
P
I
G
R
T
P
R
S
---
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
-----
S
T
N
E
A
K
V
R
G
Y
-----
K
K
G
R
F
S
F
N
V
K
G
G
R
-
C
E
A
C
H
G
D
G
I
I
K
I
E
M
H
F
L
P
D
V
Y
V
P
C
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C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
I--
P
K
-
I
---
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
---
S
NGR
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
----
D
V
L
H
R
L
V
D
-
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
111
HHSearch
90.57
38%
-78
- C3 -
2VF7
4
?
A:
[12-837]
-
D
G
G
F
V
Q
V
R
G
A
R
Q
H
N
L
K
D
I
S
V
K
V
P
R
D
A
L
V
V
F
T
G
V
S
G
S
G
K
S
S
L
A
F
G
T
L
Y
A
E
A
Q
R
R
Y
L
E
S
V
S
P
Y
A
R
R
L
F
N
Q
A
G
V
P
D
-----
V
D
A
I
D
G
---
L
P
P
A
V
A
L
Q
Q
A
R
G
T
P
T
A
R
S
S
V
G
S
V
T
T
L
S
N
L
L
R
M
L
Y
S
R
A
G
--
D
Y
--
P
P
GQGI-----------------------------------------------------------------------------------------
V
Y
--
A
E
G
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
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D
S
M
V
P
D
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P
S
L
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A
A
W
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W
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G
Q
--
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Q
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-----
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-----
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V
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D
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P
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---
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V
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GLT
P
A
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Q
R
A
L
K
K
K
M
E
P
S
Y
---
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
S
---------------------
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
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E
A
L
N
V
T
F
A
G
--------
L
D
I
T
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L
S
R
------------
L
P
L
---
A
R
V
S
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-----
L
L
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Y
A
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-----
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PGHAERVKNRPE
Q
A
I
A
L
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A
A
D
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V
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---
L
D
V
L
-------
L
H
L
G
L
G
Y
L
G
L
----
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T
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L
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L
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L
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V
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V
L
D
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L
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A
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L
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L
F
V
V
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D
L
D
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I
R
-
R
A
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W
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V
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A
G
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K
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G
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---
K
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-----
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R
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W
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N
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----
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----
N
N
L
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N
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R
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P
L
G
V
M
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S
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T
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V
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G
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K
S
T
L
V
S
Q
A
L
-----------------------------------
V
D
----------------------
A
L
A
A
H
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S
A
R
L
G
G
DLAQI-----
T
--
R
L
V
R
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V
D
Q
K
P
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G
R
T
P
R
S
---
N
M
A
T
Y
T
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L
F
D
Q
V
R
K
L
F
A
-----
A
T
P
L
A
K
K
R
G
Y
-----
N
A
G
R
F
S
F
N
V
K
G
G
R
-
C
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H
C
Q
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G
W
V
M
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L
L
F
L
P
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A
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A
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V
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A
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---
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D
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G
L
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L
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G
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G
---
T
V
Y
V
L
D
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H
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A
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V
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R
L
Q
----
R
Q
L
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L
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A
G
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V
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A
V
E
H
K
M
Q
V
V
A
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A
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G
A
G
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D
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A
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A
P
Y
L
23
PsiBlast_CBE
87.10
35%
-78
- C3 -
2VF7
4
?
B:
[15-837]
----
F
V
Q
V
R
G
A
R
Q
H
N
L
K
D
I
S
V
K
V
P
R
D
A
L
V
V
F
T
G
V
S
G
S
G
K
S
S
L
A
F
G
T
L
Y
A
E
A
Q
R
R
Y
L
E
S
V
S
P
Y
A
R
R
L
F
N
Q
A
G
V
P
D
-----
V
D
A
I
D
G
---
L
P
P
A
V
A
L
Q
Q
A
R
G
T
P
T
A
R
S
S
V
G
S
V
T
T
L
S
N
L
L
R
M
L
Y
S
R
A
G
D
Y
P
P
--
G
Q
---------------------------------------------------------------------------------------------
G
I
VY
A
E
G
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
-
P
S
L
--
T
I
R
E
R
A
-------
V
A
A
W
PQ
A
W
G
G
Q
--
N
------
Q
R
D
I
-----
L
V
T
L
GI
D
V
--
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
---
D
E
Q
P
V
V
--------------------
P
V
Y
---
P
G
L
T
P
A
E
T
Q
R
A
L
K
K
K
M
E
P
-
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
NTES
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
------------
L
P
L
A
R
V
S
E
L
L
R
-----
P
Y
A
E
E
R
E
P
G
-----
H
-----------------
A
E
R
V
K
N
R
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
YLGL
D
R
S
T
P
T
L
S
P
G
E
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R
L
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L
A
T
Q
L
Y
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L
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V
V
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A
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R
G
G
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L
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V
V
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H
D
L
D
V
I
R
-
R
A
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W
L
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V
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P
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A
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G
G
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L
Y
S
G
P
P
E
G
L
---
K
H
V
P
---
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-
S
Q
T
G
--
Q
Y
L
FA
D
--
R
H
----
T
----
E
----
P
--
H
---
T
-------
P
R
E
P
A
G
-
W
L
E
L
N
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
GQG
S
A
R
L
G
G
D-----------------
L
A
----------------------
Q
I
-----------------------
T
--
R
L
V
R
-
V
D
Q
K
P
I
G
R
T
P
R
S
---
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
-----
G
Y
-----
N
A
G
R
F
S
F
N
V
K
-
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
-----
P
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
---
E
S
A
I
---
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
---
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
----
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
22
PsiBlast_CBE
86.47
35%
-77
- C3 -
2VF7
5
?
C:
[15-837]
----
F
V
Q
V
R
G
A
R
Q
H
N
L
K
D
I
S
V
K
V
P
R
D
A
L
V
V
F
T
G
V
S
G
S
G
K
S
S
L
A
F
G
T
L
Y
A
E
A
Q
R
R
Y
L
E
S
V
S
P
Y
A
R
R
L
F
N
Q
A
G
V
P
D
-----
V
D
A
I
D
G
---
L
P
P
A
V
A
L
Q
Q
A
R
G
T
P
T
A
R
S
S
V
G
S
V
T
T
L
S
N
L
L
R
M
L
Y
S
R
A
G
DY
P
P
--
G
Q
---------------------------------------------------------------------------------------------
G
I
V
Y
A
E
G
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
-
P
S
L
--
T
I
R
E
R
A
-------
V
A
A
W
PQ
A
W
G
G
Q
--
N
------
Q
R
D
I
-----
L
V
T
L
GI
D
V
--
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
---
D
E
Q
P
V
V
--------------------
P
V
Y
---
P
G
L
T
P
A
E
T
Q
R
A
L
K
K
K
M
E
P
-
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
NTES
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
------------
L
P
L
A
R
V
S
E
L
L
R
-----
P
Y
A
E
E
R
E
P
G
-----
H
-----------------
A
E
R
V
K
N
R
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
YLGL
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
-
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
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A
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T
E
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L
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A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
---
K
H
V
P
---
E
-
S
Q
T
G
--
Q
Y
L
FA
D
--
R
H
----
T
----
E
----
P
--
H
---
T
-------
P
R
E
P
A
G
-
W
L
E
L
N
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
FG
S
A
R
L
G
G
D-------------------
L
A
----------------------
Q
I
-----------------------
T
--
R
L
V
R
-
V
D
Q
K
P
I
G
R
T
P
R
S
---
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
-----
G
Y
-----
N
A
G
R
F
S
F
N
V
K
-
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
L
L
F
L
P
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
---
E
S
A
I
---
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
---
G
RGG
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
----
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
21
PsiBlast_CBE
86.38
35%
-79
- C3 -
2VF8
10
?
B:
[15-837]
----
F
V
Q
V
R
G
A
R
Q
H
N
L
K
D
I
S
V
K
V
P
R
D
A
L
V
V
F
T
G
V
S
G
S
G
K
S
S
L
A
F
G
T
L
Y
A
E
A
Q
R
R
Y
L
E
S
V
S
P
Y
A
R
R
L
F
N
Q
A
G
V
P
D
-----
V
D
A
I
D
G
---
L
P
P
A
V
A
L
Q
Q
A
R
G
T
P
T
A
R
S
S
V
G
S
V
T
T
L
S
N
L
L
R
M
L
Y
S
R
A
G
DY
P
P
--
G
Q
---------------------------------------------------------------------------------------------
G
I
VY
A
E
G
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
-
P
S
L
--
T
I
R
E
R
A
-------
V
A
A
W
PQ
A
W
G
G
Q
--
N
------
Q
R
D
I
-----
L
V
T
L
GI
D
V
--
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
---
D
E
Q
P
V
V
--------------------
P
V
Y
---
P
G
L
T
P
A
E
T
Q
R
A
L
K
K
K
M
E
P
-
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
TES
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
------------
L
P
L
A
R
V
S
E
L
L
R
-----
P
Y
A
E
E
R
E
P
G
-----
H
-----------------
A
E
R
V
K
N
R
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
YLGL
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
-
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
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L
L
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A
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E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
---
K
H
V
P
---
E
-
S
Q
T
G
--
Q
Y
L
F
A
D
--
R
H
----
T
----
E
----
P
--
H
---
T
-------
P
R
E
P
A
G
-
W
L
E
L
N
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
GQPVNPDP
E
D
D
E
DPADHTAG
S
A
R
L
G
G
D
L
A
----------------------
Q
I
-----------------------
T
--
R
L
V
R
-
V
D
Q
K
P
I
G
R
T
P
R
S
---
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
-----
G
Y
-----
N
A
G
R
F
S
F
N
V
K
-
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
L
L
F
L
P
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
---
E
S
A
I
---
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
---
G
RG
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
----
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
1
PsiBlast_PDB
86.19
35%
-78
- C3 -
2VF7
4
?
A:
[15-837]
----
F
V
Q
V
R
G
A
R
Q
H
N
L
K
D
I
S
V
K
V
P
R
D
A
L
V
V
F
T
G
V
S
G
S
G
K
S
S
L
A
F
G
T
L
Y
A
E
A
Q
R
R
Y
L
E
S
V
S
P
Y
A
R
R
L
F
N
Q
A
G
V
P
D
-----
V
D
A
I
D
G
---
L
P
P
A
V
A
L
Q
Q
A
R
G
T
P
T
A
R
S
S
V
G
S
V
T
T
L
S
N
L
L
R
M
L
Y
S
R
A
G
D
Y
P
P
--
G
Q
---------------------------------------------------------------------------------------------
G
I
VY
A
E
G
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
-
P
S
L
--
T
I
R
E
R
A
-------
V
A
A
W
PQ
A
W
G
G
Q
--
N
------
Q
R
D
I
-----
L
V
T
L
GI
D
V
--
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
---
D
E
Q
P
V
V
--------------------
P
V
Y
---
P
G
L
T
P
A
E
T
Q
R
A
L
K
K
K
M
E
P
-
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
NTES
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
------------
L
P
L
A
R
V
S
E
L
L
R
-----
P
Y
A
E
E
R
E
P
G
-----
H
-----------------
A
E
R
V
K
N
R
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
YLGL
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
-
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
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P
A
D
T
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A
L
L
S
A
L
E
N
L
K
R
G
G
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S
L
F
V
V
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H
D
L
D
V
I
R
-
R
A
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W
L
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V
G
P
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A
G
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K
G
G
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L
Y
S
G
P
P
E
G
L
---
K
H
V
P
---
E
-
S
Q
T
G
--
Q
Y
L
FA
D
--
R
H
----
T
----
E
----
P
--
H
---
T
-------
P
R
E
P
A
G
-
W
L
E
L
N
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
GQG
S
A
R
L
G
G
D-----------------
L
A
----------------------
Q
I
-----------------------
T
--
R
L
V
R
-
V
D
Q
K
P
I
G
R
T
P
R
S
---
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
-----
G
Y
-----
N
A
G
R
F
S
F
N
V
K
-
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
L
L
F
L
P
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
---
E
S
A
I
---
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
---
G
RGG
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
----
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
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D
W
V
L
D
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G
P
G
A
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G
G
R
L
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A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
2
PsiBlast_PDB
86.01
35%
-76
- C3 -
2VF8
8
?
A:
[15-837]
----
F
V
Q
V
R
G
A
R
Q
H
N
L
K
D
I
S
V
K
V
P
R
D
A
L
V
V
F
T
G
V
S
G
S
G
K
S
S
L
A
F
G
T
L
Y
A
E
A
Q
R
R
Y
L
E
S
V
S
P
Y
A
R
R
L
F
N
Q
--
V
P
D
-----
V
D
A
I
D
G
---
L
P
P
A
V
A
L
Q
Q
A
R
G
T
P
T
A
R
S
S
V
G
S
V
T
T
L
S
N
L
L
R
M
L
Y
S
R
A
G
DY
P
P
--
G
Q
---------------------------------------------------------------------------------------------
G
I
V
Y
A
E
G
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
-
P
S
L
--
T
I
R
E
R
A
-------
V
A
A
W
PQ
A
W
G
G
Q
--
N
------
Q
R
D
I
-----
L
V
T
L
GI
D
V
--
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
---
D
E
Q
P
V
V
--------------------
P
V
Y
---
P
G
L
T
P
A
E
T
Q
R
A
L
K
K
K
M
E
P
-
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
NTES
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
------------
L
P
L
A
R
V
S
E
L
L
R
-----
P
Y
A
E
E
R
E
P
G
-----
H
-----------------
A
E
R
V
K
N
R
P
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A
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A
L
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M
A
A
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L
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D
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P
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L
R
L
A
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L
Y
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L
-
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V
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D
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D
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-
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A
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W
L
V
D
V
G
P
E
A
G
E
K
G
G
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L
Y
S
G
P
P
E
G
L
---
K
H
V
P
---
E
-
S
Q
T
G
--
Q
Y
L
FA
D
-------------
E
----
P
--
H
---
T
-------
P
R
E
P
A
G
-
W
L
E
L
N
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
GQGS
A
R
L
G
G
D-----------------
L
A
----------------------
Q
I
-----------------------
T
--
R
L
V
R
-
V
D
Q
K
P
I
G
R
T
P
R
S
---
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
-----
G
Y
-----
N
A
G
R
F
S
F
N
V
K
-
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
-----
P
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
---
E
S
A
I
---
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
---
G
RGG
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
----
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
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G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
3
PsiBlast_PDB
84.47
40%
-80
- C3 -
3UWX
2
?
A:
[283-952]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
D
L
-
D
L
V
-
I
-
P
N
D
EL
T
L
K
E
H
A
I
A
-
P
W
E
P
------
Y
Y
P
Q
L
--
L
E
A
V
C
R
H
Y
G
I
P
-----
M
-----
D
V
----
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
SGG
E
P
I
Y
F
R
Y
T
-----------
N
D
F
G
Q
V
R
E
Q
Y
I
AF
E
G
V
I
P
N
V
E
R
R
Y
R
E
T
S
----
S
---------------------
D
Y
I
R
E
Q
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
G
G
--------
K
H
I
G
E
V
T
A
------------
M
S
V
---
T
E
A
L
A
F
F
D
G
L
E
L
T
E
K
E
A
Q
I
-----
A
-----------------
R
L
I
L
R
E
I
R
D
R
---
L
G
F
L
-------
Q
N
V
G
L
D
Y
L
T
L
----
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
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S
R
L
-
T
-
G
V
L
Y
V
L
D
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P
S
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L
H
Q
R
D
N
D
R
L
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L
K
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M
R
D
L
G
N
T
L
I
V
V
E
H
D
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D
T
M
L
-
A
A
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Y
L
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D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
---
M
N
-
D
P--
N
-
S
L
T
G
--
Q
Y
L
--
S
GK
K
F
----
I
----
P
----
I
--
P
---
A
-
E
-----
R
R
R
P
D
G
R
W
L
E
V
V
G
A
R
----
E
----
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
-----------------------------------
Y
K
A
L
A
Q
K
LHRAKAKPGEHRDIRGL
E
H
-----------------------
L
--
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
---
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
-----
S
T
N
-----
E
A
K
V
R
GY
K
K
G
R
F
S
F
N
V
K
-
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
M
H
F
L
P
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
I--
P
K
-
I
---
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
---
S
NGR
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
----
D
V
L
H
R
L
V
D
-
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
4
PsiBlast_PDB
84.09
40%
-85
- C3 -
2R6F
4
?
A:
[283-952]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
D
L
-
D
L
V
-
I
-
P
N
D
EL
T
L
K
E
H
A
I
A
-
P
W
E
P
------
Y
Y
P
Q
L
L
E
A
------
V
C
R
H
-----
Y
-----
G
I
PM
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
SGG
E
P
I
Y
F
R
Y
T
-----------
N
D
F
G
Q
V
R
E
Q
Y
I
AF
E
G
V
I
P
N
V
E
R
R
Y
R
E
T
S
----
S
---------------------
D
Y
I
R
E
Q
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
G
G
--------
K
H
I
G
E
V
T
A
MS
V
T
E
A
L
A
F
F
D
G
L
E
L
---
T
E
K
E
A
-----
Q
I
A
R
L
-----------------------------
I
L
R
E
I
R
D
R
---
L
G
F
L
-------
Q
N
V
G
L
D
Y
L
T
L
----
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
-
T
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G
V
L
Y
V
L
D
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P
S
I
G
L
H
Q
R
D
N
D
R
L
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A
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L
K
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M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
-
A
A
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Y
L
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I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
---
M
N
-
D
P--
N
-
S
L
T
G
--
Q
Y
L
--
S
GK
K
F
----
I
----
P
----
I
--
P
---
A
-
E
-----
R
R
R
P
D
G
R
W
L
E
V
V
G
A
R
----
E
----
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
-----------------------------------
Y
K
A
L
A
Q
K
LHRAK
A
K
P
G
EHRDIRGL
E
H
-----------------------
L
--
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
---
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
-----
S
T
N
-----
E
A
K
V
R
GY
K
K
G
R
F
S
F
N
V
K
-
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
M
H
F
L
P
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
I--
P
K
-
I
---
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
---
S
NGR
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
----
D
V
L
H
R
L
V
D
-
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
5
PsiBlast_PDB
80.06
38%
-74
- C3 -
3ZQJ
2
UVRA_MYCTU
A:
[294-970]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P
D
-
P
D
R
--
T
L
A
Q
G
A
V
A
-
P
W
S
N
G
H
T
A
--
E
Y
F
T
R
--
M
------
M
A
G
L
GEALG
F
-----
D
V
--
D
T
P
W
R
K
L
P
A
K
A
R
K
A
I
L
E
G
---
A
D
E
Q
V
H
V
R
Y
R
N
RY------
G
R
T
R
S
Y
Y
A
D
F
---
E
G
V
L
A
F
L
Q
R
K
M
S
Q
T
E
S
E
Q
-------------------------
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
G
E
SKGEH
G
A
K
S
I
A
E
V
C
E
------------
L
S
I
---
A
D
C
A
D
FLNAL
T
L
G
P
R
E
Q
A
I
-----
A
-----------------
G
Q
V
L
K
E
I
R
S
R
---
L
G
F
L
-------
L
D
V
G
L
E
Y
L
S
L
----
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
-
V
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
E
T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
-
H
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
---
L
R
-
N
K--
D
-
S
I
T
G
--
A
Y
L
--
S
--
G
R
E
S
I
E
I
----
P
----
A
--
I
---
R
-
R
-----
S
V
D
P
R
R
-
Q
L
T
V
V
G
A
R
----
E
----
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
-----------------------------------
A
A
V
L
A
N
R
LNGARQVPGRHTRVTGL
D
Y
-----------------------
L
--
D
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
---
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
-----
A
T
T
-----
E
A
K
V
R
GY
Q
P
G
R
F
S
F
N
V
K
-
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
M
N
F
L
P
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
I--
A
G
-
V
---
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
---
S
TG
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
----
N
V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
24
PsiBlast_CBE
79.37
38%
-73
- C3 -
3ZQJ
2
UVRA_MYCTU
E:
[294-970]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P
D
-
P
D
R
--
T
L
A
Q
G
A
V
A
-
P
W
S
N
G
H
T
A
--
E
Y
F
T
R
--
M
------
M
A
G
L
G
EALG
F
-----
D
V
--
D
T
P
W
--
L
P
A
K
A
R
K
A
I
L
E
G
---
A
D
E
Q
V
H
V
R
YRNRY------
G
R
T
R
S
Y
Y
A
D
F
---
E
G
V
L
A
F
L
Q
R
K
M
S
Q
T
E
S
E
Q
-------------------------
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
-KGEHGA--
K
S
I
A
E
V
C
E
------------
L
S
I
---
A
D
C
A
D
FLNAL
T
L
G
P
R
E
Q
A
I
-----
A
-----------------
G
Q
V
L
K
E
I
R
S
R
---
L
G
F
L
-------
L
D
V
G
L
E
Y
L
S
L
----
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
-
V
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
E
T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
-
H
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
---
L
R
-
N
K--
D
-
S
I
T
G
--
A
Y
L
--
S
--
G
R
E
S
I
E
I
----
P
----
A
--
I
---
R
-
R
-----
S
V
D
P
R
R
-
Q
L
T
V
V
G
A
R
----
E
----
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
-----------------------------------
A
A
V
L
A
N
R
LNGARQVPGRHTRVTGL
D
Y
-----------------------
L
--
D
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
---
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
-----
A
T
T
-----
E
A
K
V
R
GY
Q
P
G
R
F
S
F
N
V
K
-
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
M
N
F
L
P
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
I--
A
G
-
V
---
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
---
S
TG
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
----
N
V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
26
PsiBlast_CBE
79.26
38%
-76
- C3 -
3ZQJ
2
UVRA_MYCTU
B:
[294-970]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P--------------
A
-
P
W
S
N
G
H
T
A
--
E
Y
F
T
R
--
M
------
M
A
G
L
G
EALG
F
-----
D
V
--
D
T
P
W
R
K
L
P
A
K
A
R
K
A
I
L
E
G
---
A
D
E
Q
V
H
V
R
Y
R
N
RY------
G
R
T
R
S
Y
Y
A
D
F
---
E
G
V
L
A
F
L
Q
R
K
M
S
Q
T
E
S
E
Q
-------------------------
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
G
ESKGEHGA
K
S
I
A
E
V
C
E
------------
L
S
I
---
A
D
C
A
D
FLNAL
T
L
G
P
R
E
Q
A
I
-----
A
-----------------
G
Q
V
L
K
E
I
R
S
R
---
L
G
F
L
-------
L
D
V
G
L
E
Y
L
S
L
----
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
-
V
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
E
T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
-
H
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
---
L
R
-
N
K--
D
-
S
I
T
G
--
A
Y
L
--
S
--
G
R
E
S
I
E
I
----
P
----
A
--
I
---
R
-
R
-----
S
V
D
P
R
R
-
Q
L
T
V
V
G
A
R
----
E
----
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
-----------------------------------
A
A
V
L
A
N
R
L
NGARQVPGRHTRVTGL
D
Y
-----------------------
L
--
D
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
---
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
-----
A
T
T
-----
E
A
K
V
R
GY
Q
P
G
R
F
S
F
N
V
K
-
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
M
N
F
L
P
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
I--
A
G
-
V
---
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
---
S
TG
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
----
N
V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
25
PsiBlast_CBE
76.75
38%
-74
- C3 -
3ZQJ
2
UVRA_MYCTU
C:
[294-970]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P------------
A
V
A
-
P
W
S
N
G
H
T
A
--
E
Y
F
T
R
--
M
------
M
A
G
L
G
E
A
L
G-------------------
K
A
R
K
A
I
L
E
G
---
A
D
E
Q
V
H
V
R
Y
RNRY------
G
R
T
R
S
Y
Y
A
D
F
---
E
G
V
L
A
F
L
Q
R
K
M
S
Q
T
E
S
E
Q
-------------------------
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
G
HGA-----
K
S
I
A
E
V
C
E
------------
L
S
I
---
A
D
C
A
D
F
L
N
A
L
T
L
G
P
R
E
Q
A
I
-----
A
-----------------
G
Q
V
L
K
E
I
R
S
R
---
L
G
F
L
-------
L
D
V
G
L
E
Y
L
S
L
----
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
-
V
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
E
T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
-
H
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
---
L
R
-
N
K--
D
-
S
I
T
G
--
A
Y
L
--
S
--
G
R
E
S
I
E
I
----
P
----
A
--
I
---
R
-
R
-----
S
V
D
P
R
R
-
Q
L
T
V
V
G
A
R
----
E
----
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
-----------------------------------
A
A
V
L
A
N
R
LNGARQVPGRHTRVTGL
D
Y
-----------------------
L
--
D
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
---
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
-----
A
T
T
-----
E
A
K
V
R
GY
Q
P
G
R
F
S
F
N
V
K
-
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
M
N
F
L
P
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
I--
A
G
-
V
---
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
---
S
TG
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
----
N
V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
119
HHSearch
62.82
39%
-83
- C3 -
3PIH
3
UVRA_THEMA
A:
[587-903]
--
Y
A
S
L
K
I
K
G
V
R
H
N
N
L
K
N
I
D
V
E
I
P
L
G
V
F
V
C
V
T
G
V
S
G
S
G
K
S
S
L
V
M
E
T
L
Y
P
A
L
M
N
L
L
H
K
T
K
----------
L
P
A
G
E
-----
F
D
S
I
E
G
HEN
I
D
K
M
I
A
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
K
V
F
D
E
I
R
S
L
F
A
M
T
P
A
A
K
A
--
R
G
---------------------------------------------------------------------------------------------
Y
N
--
K
S
R
F
S
F
N
L
K
G
G
R
C
E
A
C
Q
G
Q
G
Y
V
K
I
-
E
-----------------------------------------------------------------------------------------------------------
M
L
F
L
P
---------------------------------------------------------
D
V
Y
V
E
C
D
V
C
K
G
K
R
Y
N
R
E
T
L
E
I
T
Y
K
G
--------
K
N
I
S
D
I
L
D
------------
M
T
V
---
D
E
A
L
E
-----
F
F
K
N
I
-------------------------------
P
S
I
K
R
T
---
L
Q
V
L
-------
H
D
V
G
L
G
Y
V
K
L
----
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
I
K
L
A
S
E
L
R
K
R
D
-
T
G
R
T
L
Y
I
L
D
E
P
T
V
G
L
H
F
E
D
V
R
K
L
V
E
V
L
H
R
L
V
D
R
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
N
A
D
H
I
I
D
L
G
P
E
G
G
K
E
G
G
Y
I
V
A
T
G
T
P
E
E
I
---
A
K
-
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
59.38
35%
-75
- C3 -
2VF7
3
?
A:
[501-828]
---
G
W
L
E
L
N
G
V
T
R
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
-----------------G
S
A
R
L
G
G
D
L
A
Q
---
I
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
---------------------------------------------------------------------------------------------
Y
N
--
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
------------------------------------------------------------------------------------------------------------
L
L
F
L
---------------------------------------------------------
P
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
--------
K
N
I
A
D
V
L
A
------------
L
T
V
---
D
E
A
H
D
-----
F
F
A
D
E
-------------------------------
S
A
I
F
R
A
---
L
D
T
L
-------
R
E
V
G
L
G
Y
L
R
L
----
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
-
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
---
A
Q
-
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
HHSearch
58.96
36%
-73
- C3 -
2R6F
3
?
A:
[628-943]
---
R
W
L
E
V
V
G
A
R
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
L
H
R
A
K
A
-------
K
P
G
E
H
R
D
-----
I
R
G
L
E
H
---
L
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
--
E
A
K
V
R
G
---------------------------------------------------------------------------------------------
Y
K
--
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
-
E
M
-----------------------------------------------------------------------------------------------------------
H
F
L
---------------------------------------------------------
P
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
--------
K
N
I
A
E
V
L
D
------------
M
T
V
---
E
D
A
L
D
-----
F
F
A
S
I
-------------------------------
P
K
I
K
R
K
---
L
E
T
L
-------
Y
D
V
G
L
G
Y
M
K
L
----
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
-
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
---
A
E
-
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
58.15
27%
-67
- C3 -
3BK7
2
?
A:
[215-546]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
E
L
E
N
V
-
L
----
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
-
H
---
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
G
K
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
Y
G
E
P
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
G
I
N
E
F
L
Q
-
G
---
Y
-
L
K
D
E
NV
R
F
R
--
P
--
Y
E
I
R
--
F
T---
K
----
L
--
S
---
E
R
V
-----
D
V
E
R
E
T
-
L
V
E
Y
P
R
L
V
----
K
D
YGS
F
K
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
-----------------------------------
G
V
----------------------
E
E
-----------------------
P
T
E
G
K
V
E
-
W
D
L
T
---------------------------------------------------------------------------
V
A
Y
K
P
Q
Y
I
-------------------------
K
A
E
Y
E
G
T
V
Y
E
L
L
S
K
I
D
S
S
K
L
N
S
-
N
---
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
-
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
---
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
----
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
-------------------------------
117
HHSearch
57.07
28%
-67
- C3 -
1YQT
4
?
A:
[146-477]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
L
E
N
V
-
L
----
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
-
T
---
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
G
K
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
Y
G
E
P
G
V
Y
G
I
F
S
Q
P
K
G
T
R
N
G
I
---
N
E
--------
F
L
R
--
G
Y
L
--
K
--
D
E
NVRF
R
----
P
Y
E
I
K
F
--
T
KTG
E
-
R
V----
E
I
E
R
E
T
-
L
V
T
Y
P
R
L
V
K
D
YG
S
----
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
-----------------------------------
G
V
----------------------
E
E
-----------------------
P
T
E
G
K
I
E
-
W
D
L
T
V
---------------------------------------------------------------------------
A
Y
K
P
Q
Y
I
-------------------------
K
A
D
Y
E
G
T
V
Y
E
L
L
S
K
I
D
A
S
K
L
N
S
-
N
---
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
---
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
----
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
G
------------------------------
115
HHSearch
53.63
21%
-59
- C3 -
3J16
2
RLI1_YEAST
B:
[207-558]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
L
Q
L
E
N
V
-
L
----
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
-
D
---
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
Q
R
L
N
A
A
Q
I
I
R
S
L
L
A
P
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
Y
G
V
P
S
V
-
Y
G
V
V
T
L
P
A
S
V
R
E
G
---
I
N
-
I
F
L
D
G
-
H
I
P
A
--
E
N
L
--
R
--
F
R
T---
E
A
L
Q
F
R
----
I
--
A
---
D
-
A
TEDLQ
N
D
S
A
S
R
-
A
F
S
Y
P
S
L
K
K
T
QG
D
----
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
-----------------------------------
G
A
----------------------
L
K
-----------------------
P
--
D
E
-----
G
Q
D
I
P
K
---------------------------------------------------------------------
L
N
V
S
M
K
P
Q
K
I
A
-------
P
K
F
P
G
----------
T
V
R
Q
L
F
F
K
K
I
R
G
Q
---
F
L
-----
N
-
P
---
Q
F
Q
T
D
V
V
K
P
L
R
I
D
D
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
---
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
----
K
V
I
R
R
F
I
L
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
G
I
----
P
S
K
N
A
H
A
R
A
P
E
S
L
L
-----------
6
PsiBlast_PDB
53.33
25%
-65
- C3 -
3BK7
2
?
A:
[221-549]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
----
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
-
H
---
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
G
K
A
V
L
V
V
E
H
D
L
A
V
L
D
-
Y
L
S
D
V
I
H
V
------
V
Y
G
E
P
G
V
Y
G
I
F
S
K
P
---
K
G
-
T
---
R
-
N
G
I
N
--
E
F
L
--
Q
--
G
Y
----
L
----
K
----
D
--
E
---
N
-
V
-----
R
F
R
P
Y
E
-
I
R
F
T
K
L
S
E
----
R
----
V
D
V
E
---------------------
R
E
T
L
V
---------------------------------------------------------------
E
Y
-----------------------
P
---
R
L
V
-
K
D
Y
G
S
F
K
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
--------------------------------------------
N
G
I
G
K
T
T
F
-
V
K
M
L
A
G
V
E
E
P
T
E
---
G
K
V
E
W
D
L
T
V
A
Y
K
--
P
Q
Y
I
K
A
E
Y
E
G
T
V
Y
E
L
L
S
K
I
D
S
---
S
K
-
L
N
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
-
I
D
L
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
---
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
---
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
-
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
----
D
Y
V
S
D
R
---------
L
I
V
F
E
G
E
P
---------------