@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2488: (2016-04-04 )
LDKEKIVIQGARAHNLKNIDVEIPRDKLVVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDLIEGLSPAISIDQKTTSRNPRSTVGTVTEIHDYLRLLYARVGHPVCPNHGIEITSQTIEQMVDRVLEYPEKTRIQIMAPIVSGKKGTHKKTIEEIKKEGYVRIRVDGEIYDINDEIEIEKNKKHSIEIIIDRIVIKEGINTRLYDSIEAALRLADGYAVVDIMGDKELLFSEHYACPYCGFSVGELEPRMFSFNSPFGACPTCDGLGTKLEVDVDTVIPDRSMSLNEGAIIPWRPISSQYYPQMLASACKEFGIDMDTPLEKLSKEELDIILNGSKDKEFYFEYKNDFGMTRETWIPFEGILPNIERRYRETNSDFTRDQMAQYMTDLPCPSCKGYRLKEETLSVKVNDHHIGQISEFSINEALAFFDGLELSEKETQIAAPIFKEVRARLGFLKNVGLDYLTMSRAAGTLSGGEAQRIRLATQIGSRLTGVLYILDEPSIGLHQRDNDRLISTLQSMRDIGNTLIVVEHDEDTMMAADYLIDIGPGAGEHGGRIVAAGTPEEVANNKNSITGDYLSGKKFIPVPAKRRKGNGLELEIIGAKANNLKNVNAKIPLATFSCVTGVSGSGKSSLVNEVLRKALARKLNRNHAKPGEHKEIKGIENLEKIINIDQSPIGRTPRSNPATYTGAFDDIRDLFASTNEAKVRGYKKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCHGKRYNGETLDIRYKGKNIAEVLEMTVEEGLEYFTNQPRIARKLQTIVDVGLGYIRLGQPATTLSGGEAQRVKLASELHKRSNGKSFYILDEPTTGLHADDIGRLLKVLQRLVEENGDTVLVIEHNLDVIKQADYLIDLGPEGGDGGGQIIATGTPEKIARSKKSYTGKYLKPILERDKERTEERIATAKKK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80--.........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240--........250...-....260.......270.......280.......290.......300.......-310.......320.......330.......340.......350...-....360----...-----......370.......380..----.....----390.......400.......410.......420.-----...---...430...---....440........450-----------.------------.......460.......470.......480.......490.......500....-...510.......520.......530.......540.......550-.......560.......570.......580.......590...------.------...600-...-.---.....610.......----.----620.......630.......640.......650.......660.-------------.....-------.670.....-..680-........690.......700.......710.......720-........730.......740.......750.------------------------------------------------------------------------------------...----------------------------....760.......770.......780.......790.......---800----------------------........810.......820.......830.......840.......850.......860.......870.......880.......890...-....900.......910.......920.......930.......940.......950....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LDK
E
K
I
V
I
QGARAHNL
K
N
I
D
V
EIPR
D
K
L
V
V
M
TGLSGSGKS
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
GQMDKP
D
V
D
L
I
EG---LSP
A
I
S
IDQKTTSRNPRSTVG
T
V
T
E
I
H
D
Y
L
R
L
L
Y
A
RVGHPVCPNHGIEI
T
S
Q
T
I
E
Q
M
V
D
R
V
LEYPEK
T
R
I
Q
I
M
A
P
I
VSGKKGT
H
K
K
T
I
E
E
I
K
KE
G
Y
V
R
I
R
VD
G
E
I
Y
DIND
E
I
E
I
EKNKK
H
S
I
E
I
I
I
D
R
I
V
I
KEGIN
T
R
L
Y
D
S
I
E
A
A
L
R
LAD
G
Y
A
V
V
D
IMGD---
K
E
L
L
F
SEHYACPYC-GFSVGELE
P
R
M
FSFNSPFGACPTCDGLG
T
K
L
E
V
D
V
D
T
VIPDRSMSLNEG
A
I
I
PW-RPIS
S
Q
Y
Y
P
Q
M
L
A
S
A
C
K
EFGIDMD
T
P
L
E
K
LSKEE
L
D
I
I
LNGSKD
K
E
-
F
Y
F
E
Y------KND-----FGMTRETWI
P
F
E
G
IL
P
N
I
E
R
R
----
Y
RETN----SDF
T
R
D
Q
M
A
Q
Y
M
TDLPCPSCKG
Y
R
L
K
E
E
T
L
S
V
K
V-----NDH---HIGQ
I
S
EF
S
---
I
N
E
A
L
-
A
F
FDGLELSE
K
------------
E
------------
T
Q
I
A
A
P
I
F
K
E
V
R
A
R
L
G
F
L
K
NVGLD
Y
L
TMSRAAGTLSGGE
A
Q
R
I
R
L
A
T
Q
I
GSR
L
T
-
G
V
L
Y
I
LDEPSIGLHQRD
N
D
R
L
I
S
T
L
Q
S
M
R
D
IG
N
T
L
I
V
V
EHDED
T
M
M
-
A
A
D
Y
L
I
DIGPGAGEHG
G
R
I
V
AAG
T
P
E
E
VANNKNSITGDYLSGK------K------FIPV---PAK-R---RKGNG
L
-
E
L
E
I
I
GAK----A----NNLKNVNAKIP
L
A
T
F
S
C
VTGVSGS
G
K
S
S
L
V
N
E
V
L
R
K
A
L
A
R
K
LNR-------------NHAKP-------GE
H
K
EIK
G
I
-
E
N
L
E
--
K
I
INIDQSPIGRTPRSNPATYTG
A
F
D
D
I
R
D
L
FASTN
E
A
K
V
--
R
G
Y
KKG
R
F
S
F
NVKG
G
R
C
E
ACKGD
G
I
I
K
I
E
-
M
H
------------------------------------------------------------------------------------FLP----------------------------DVYV
P
C
E
VCHGKRYNG
E
T
L
D
I
R
YKGK
N
I
A
E
V
L
E
M
T
V
E
E
G
L
E
Y
FT---N
Q
-----------------------
P
R
I
A
R
K
L
Q
T
I
V
D
VGL
G
Y
I
RLGQPATTLSGG
E
A
Q
R
V
K
L
A
S
E
L
H
KRSNG
K
S
F
Y
I
L
DEPTTGL
H
A
D
D
I
G
R
L
L
K
V
L
Q
R
L
V
EENG
D
T
V
L
V
I
EHN
L
D
V
I
K-QA
D
Y
L
I
D
LGPEGGDGG
G
Q
I
I
ATG
T
P
E
K
I
A
R
S
K
K
SY
T
G
K
Y
L
K
P
I
L
E
R
D
K
E
R
T
E
E
R
I
ATAKKK
1
PsiBlast_PDB
94.77
75%
-89
- C2 -
3UWX
3
?
A:
[22-969]
---
D
K
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
---
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
I
V
S
G
K
K
G
T
H
A
K
T
L
E
D
I
R
K
Q
G
Y
V
R
V
R
I
D
R
E
M
R
E
L
T
G
D
I
E
L
E
K
N
K
K
H
S
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
G
E
---
G
E
L
L
F
S
E
K
H
A
C
P
Y
C
-
G
F
S
I
G
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
D
L
D
L
V
I
P
N
D
E
L
T
L
K
E
H
A
I
A
P
W
-
E
P
----
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
S
G
G
E
P
-
I
Y
F
R
Y
------
T
N
D
-----
F
G
Q
V
R
E
Q
Y
I
A
F
E
G
V
I
P
N
V
E
R
R
----
Y
R
E
T
S
----
S
D
Y
I
R
E
Q
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
-----
G
G
K
---
H
I
G
E
V
T
A
M
S
---
V
T
E
A
L
-
A
F
F
D
G
L
E
L
T
E
K
------------
E
------------
A
Q
I
A
R
L
I
L
R
E
I
R
D
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
T
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
-
A
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
M
N
D
P
N
S
L
T
G
Q
Y
L
S
G
K
------
K
------
F
I
P
I
---
P
A
E
-
R
---
R
R
P
D
G
R
-
W
L
E
V
V
G
A
R
----
E
----
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
L
H
R
-------------
A
K
A
K
P
-------
G
E
H
R
D
I
R
G
L
-
E
H
L
D
--
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
--
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
-
M
H
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
---
S
I
-----------------------
P
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
-
D
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
P
I
L
E
R
D
R
A
R
M
Q
A
R
Y
E
A
----
95
HHSearch
90.94
75%
-85
- C2 -
2R6F
5
?
A:
[21-969]
--
M
D
K
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
---
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
----------------------------------------------
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
G
E
---
G
E
L
L
F
S
E
K
H
A
C
P
Y
C
-
G
F
S
I
G
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
D
L
D
L
V
I
P
N
D
E
L
T
L
K
E
H
A
I
A
P
W
-
E
P
----
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
S
G
G
E
P
I
Y
F
R
Y
T
------
N
D
------
F
G
Q
V
R
E
Q
Y
I
A
F
E
G
V
I
P
N
V
E
R
R
----
Y
R
E
T
S
----
S
D
Y
I
R
E
Q
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
-----
G
G
K
---
H
I
G
E
V
T
A
M
S
---
V
T
E
A
L
-
A
F
F
D
G
L
E
L
T
E
K
------------
E
------------
A
Q
I
A
R
L
I
L
R
E
I
R
D
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
T
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
-
A
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
M
N
D
P
N
S
L
T
G
Q
Y
L
S
G
K
------
K
------
F
I
P
I
---
P
A
E
-
R
---
R
R
P
D
G
R
-
W
L
E
V
V
G
A
R
----
E
----
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
L
H
R
-------------
A
K
A
K
P
-------
G
E
H
R
D
I
R
G
L
-
E
H
L
D
--
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
--
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
-
M
H
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
---
S
I
-----------------------
P
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
-
D
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
P
I
L
E
R
D
R
A
R
M
Q
A
R
Y
E
A
----
2
PsiBlast_PDB
90.84
74%
-86
- C2 -
2R6F
5
?
A:
[22-969]
---
D
K
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
---
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
----------------------------------------------
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
G
E
---
G
E
L
L
F
S
E
K
H
A
C
P
Y
C
-
G
F
S
I
G
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
D
L
D
L
V
I
P
N
D
E
L
T
L
K
E
H
A
I
A
P
W
-
E
P
----
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
S
G
G
E
P
-
I
Y
F
R
Y
------
T
N
D
-----
F
G
Q
V
R
E
Q
Y
I
A
F
E
G
V
I
P
N
V
E
R
R
----
Y
R
E
T
S
----
S
D
Y
I
R
E
Q
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
-----
G
G
K
---
H
I
G
E
V
T
A
M
S
---
V
T
E
A
L
-
A
F
F
D
G
L
E
L
T
E
K
------------
E
------------
A
Q
I
A
R
L
I
L
R
E
I
R
D
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
T
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
-
A
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
M
N
D
P
N
S
L
T
G
Q
Y
L
S
G
K
------
K
------
F
I
P
I
---
P
A
E
-
R
---
R
R
P
D
G
R
-
W
L
E
V
V
G
A
R
----
E
----
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
L
H
R
-------------
A
K
A
K
P
-------
G
E
H
R
D
I
R
G
L
-
E
H
L
D
--
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
--
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
-
M
H
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
---
S
I
-----------------------
P
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
-
D
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
P
I
L
E
R
D
R
A
R
M
Q
A
R
Y
E
A
----
3
PsiBlast_PDB
84.67
56%
-74
- C2 -
3ZQJ
3
UVRA_MYCTU
A:
[24-974]
---
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
---
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
T
C
G
E
R
V
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
E
G
T
R
F
L
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
V
D
R
L
T
V
K
A
A
A
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
L
E
F
V
D
-----
E
Q
R
F
S
E
K
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P
D
P
D
R
T
L
A
Q
G
A
V
A
P
W
S
N
G
H
T
A
E
Y
F
T
R
M
M
A
G
L
G
E
A
L
G
F
D
V
D
T
P
W
R
K
L
P
A
K
A
R
K
A
I
L
E
G
A
-
D
E
Q
-
V
H
V
R
Y
------
R
N
R
-----
Y
G
R
T
R
S
Y
Y
A
D
F
E
G
V
L
A
F
L
Q
R
K
----
M
S
Q
T
E
----
S
E
Q
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
G
E
SK
G
E
H
G
A
K
S
I
A
E
V
C
E
L
S
---
I
A
D
C
A
-
D
F
L
N
A
L
T
L
G
P
R
------------
E
------------
Q
A
I
A
G
Q
V
L
K
E
I
R
S
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
V
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
E
T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
-
H
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
L
R
N
K
D
S
I
T
G
A
Y
L
S
G
R
------
E
------
S
I
E
I
---
P
A
I
-
R
---
R
S
V
D
P
R
R
Q
L
T
V
V
G
A
R
----
E
----
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
N
R
L
N
G
-------------
A
R
Q
V
P
-------
G
R
H
T
R
V
T
G
L
-
D
Y
L
D
--
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
V
--
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
-
M
N
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
---
P
I
-----------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
K
-
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
A
E
V
V
-----------------
23
PsiBlast_CBE
81.96
56%
-73
- C2 -
3ZQJ
3
UVRA_MYCTU
B:
[24-974]
---
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
---
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
T
C
G
E
R
V
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
E
G
T
R
F
L
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
V
D
--------
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
L
------------
F
S
E
K
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P
-----------
A
P
W
S
N
G
H
T
A
E
Y
F
T
R
M
M
A
G
L
G
E
A
L
G
F
D
V
D
T
P
W
R
K
L
P
A
K
A
R
K
A
I
L
E
G
A
-
D
E
Q
-
V
H
V
R
Y
------
R
N
R
-----
Y
G
R
T
R
S
Y
Y
A
D
F
E
G
V
L
A
F
L
Q
R
K
----
M
S
Q
T
E
----
S
E
Q
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
GESK
G
E
H
GAK
S
I
A
E
V
C
E
L
S
---
I
A
D
C
A
-
D
F
L
N
A
L
T
L
G
P
R
------------
E
------------
Q
A
I
A
G
Q
V
L
K
E
I
R
S
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
V
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
E
T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
-
H
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
L
R
N
K
D
S
I
T
G
A
Y
L
S
G
R
------
E
------
S
I
E
I
---
P
A
I
-
R
---
R
S
V
D
P
R
R
Q
L
T
V
V
G
A
R
----
E
----
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
N
R
L
N
G
-------------
A
R
Q
V
P
-------
G
R
H
T
R
V
T
G
L
-
D
Y
L
D
--
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
V
--
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
-
M
N
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
---
P
I
-----------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
K
-
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
A
E
V
V
-----------------
21
PsiBlast_CBE
81.56
56%
-71
- C2 -
3ZQJ
2
UVRA_MYCTU
E:
[24-974]
---
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
---
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
------
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
E
G
T
R
F
L
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
V
D
--------
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
L
E
F
V
D
H
-----------
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P
D
P
D
R
T
L
A
Q
G
A
V
A
P
W
S
N
G
H
T
A
E
Y
F
T
R
M
M
A
G
L
G
E
A
L
G
F
D
V
D
T
P
W
--
L
P
A
K
A
R
K
A
I
L
E
G
A
-
D
E
Q
-
V
H
V
R
Y
------
R
N
R
-----
Y
G
R
T
R
S
Y
Y
A
D
F
E
G
V
L
A
F
L
Q
R
K
----
M
S
Q
T
E
----
S
E
Q
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
AK---
G
E
H
GAK
S
I
A
E
V
C
E
L
S
---
I
A
D
C
A
-
D
F
L
N
A
L
T
L
G
P
R
------------
E
------------
Q
A
I
A
G
Q
V
L
K
E
I
R
S
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
V
-
G
V
L
Y
V
L
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P
S
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G
L
H
Q
R
D
N
R
R
L
I
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T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
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E
-
H
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
L
R
N
K
D
S
I
T
G
A
Y
L
S
G
R
------
E
------
S
I
E
I
---
P
A
I
-
R
---
R
S
V
D
P
R
R
Q
L
T
V
V
G
A
R
----
E
----
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
N
R
L
N
G
-------------
A
R
Q
V
P
-------
G
R
H
T
R
V
T
G
L
-
D
Y
L
D
--
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
V
--
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
-
M
N
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
---
P
I
-----------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
K
-
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
A
E
V
V
-----------------
22
PsiBlast_CBE
79.80
56%
-73
- C2 -
3ZQJ
3
UVRA_MYCTU
C:
[24-974]
---
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
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S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
---
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
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P
T
C
G
E
R
V
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
------
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
----------
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
-----------------
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P
---------
A
V
A
P
W
S
N
G
H
T
A
E
Y
F
T
R
M
M
A
G
L
G
E
A
L
G
------------
K
A
R
K
A
I
L
E
G
A
-
D
E
Q
-
V
H
V
R
Y
------
R
N
R
-----
Y
G
R
T
R
S
Y
Y
A
D
F
E
G
V
L
A
F
L
Q
R
K
----
M
S
Q
T
E
----
S
E
Q
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
AG-----
H
GAK
S
I
A
E
V
C
E
L
S
---
I
A
D
C
A
-
D
F
L
N
A
L
T
L
G
P
R
------------
E
------------
Q
A
I
A
G
Q
V
L
K
E
I
R
S
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
V
-
G
V
L
Y
V
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D
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P
S
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G
L
H
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R
L
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D
L
G
N
T
L
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V
E
H
D
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E
-
H
A
D
W
I
V
D
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P
G
A
G
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R
I
V
H
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G
P
Y
D
E
L
L
R
N
K
D
S
I
T
G
A
Y
L
S
G
R
------
E
------
S
I
E
I
---
P
A
I
-
R
---
R
S
V
D
P
R
R
Q
L
T
V
V
G
A
R
----
E
----
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
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V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
N
R
L
N
G
-------------
A
R
Q
V
P
-------
G
R
H
T
R
V
T
G
L
-
D
Y
L
D
--
K
L
V
R
V
D
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I
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R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
V
--
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
-
M
N
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
---
P
I
-----------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
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L
Q
K
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T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
K
-
G
N
T
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E
H
N
L
D
V
I
K
-
T
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D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
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T
P
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D
V
A
A
V
P
A
S
Y
T
G
K
F
L
A
E
V
V
-----------------
94
HHSearch
72.01
44%
-70
* C2 *
2VF7
4
?
A:
[12-841]
-
D
G
G
F
V
Q
V
R
G
A
R
Q
H
N
L
K
D
I
S
V
K
V
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D
A
L
V
V
F
T
G
V
S
G
S
G
K
S
S
L
A
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L
Y
A
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A
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R
R
Y
L
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V
S
P
Y
A
R
R
L
F
N
Q
A
G
V
P
D
V
D
A
I
D
G
---
L
P
P
A
V
A
L
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Q
A
R
G
T
P
T
A
R
S
S
V
G
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V
T
T
L
S
N
L
L
R
M
L
Y
S
R
A
G
D
Y
P
P
G
-
Q
G
I
------------------------------------------------------------------------------------------------------------------------------------------
V
Y
A
E
G
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
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M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
-
P
Q
A
W
---
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
V
-
V
P
V
Y
P
------
G
L
T
P
A
E
T
Q
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
----
V
L
H
T
F
A
NTE
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
-----
A
G
L
---
D
I
T
E
L
S
R
L
P
---
L
A
R
V
S
-
E
L
L
R
P
Y
A
E
E
R
E
PGHAERVKNRPE
Q
------------
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
------
R
------
H
T
E
P
---
H
-
T
-
P
---
R
E
-
P
A
G
-
W
L
E
L
N
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
-------------------------
G
S
-
A
R
L
G
G
D
L
A
Q
I
T
--
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
-
L
L
------------------------------------------------------------------------------------
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
---
D
E
-----------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
-
D
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
-----------------
4
PsiBlast_PDB
62.73
41%
-61
- C2 -
2VF7
4
?
A:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
----
P
Q
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
-
T
D
E
Q
P
-
V
V
P
V
Y
P
GLT
P
A
E
T
Q
-----
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
----
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
-----
A
G
L
---
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
A
E
E
R
E
P
G
H
A
------------
E
RVKNRPE
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
----
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
------
R
------
H
T
E
P
---
H
T
P
-
R
---
E
P
A
G
W
L
-
E
L
N
--
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
-------------------------
G
S
A
R
L
G
G
D
L
-
A
Q
I
T
--
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
-
L
L
------------------------------------------------------------------------------------
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
---
D
E
-----------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
-
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
-----------------
26
PsiBlast_CBE
62.49
41%
-58
- C2 -
2VF7
4
?
B:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
----
P
Q
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
-
T
D
E
Q
P
-
V
V
P
V
Y
P
GLT
P
A
E
T
Q
-----
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
----
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
-----
A
G
L
---
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
A
E
E
R
E
P
G
H
A
------------
E
R
V
K
N
R
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
----
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
------
R
------
H
T
E
P
---
H
T
P
-
R
---
E
P
A
G
W
L
-
E
L
N
--
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
-------------------------
G
S
A
R
L
G
G
D
L
-
A
Q
I
T
--
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
------------------------------------------------------------------------------------------
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
---
D
E
-----------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
-
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
-----------------
24
PsiBlast_CBE
62.27
41%
-61
- C2 -
2VF8
9
?
B:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
----
P
Q
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
-
T
D
E
Q
P
-
V
V
P
V
Y
P
GLT
P
A
E
T
Q
-----
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
----
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
-----
A
G
L
---
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
A
E
E
R
E
P
G
H
A
------------
E
R
V
K
NR
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
----
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
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P
S
A
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L
H
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A
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A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
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K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
------
R
------
H
T
E
P
---
H
T
P
-
R
---
E
P
A
G
W
L
-
E
L
N
--
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
PVNPDP
E
D
D
E
DPA
D
H
T
A
--------
G
S
A
R
L
G
G
D
L
-
A
Q
I
T
--
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
-
L
L
------------------------------------------------------------------------------------
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
---
D
E
-----------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
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E
L
S
G
G
E
A
Q
R
I
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L
A
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L
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R
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G
R
G
G
T
V
Y
V
L
D
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T
T
G
L
H
P
A
D
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E
R
L
Q
R
Q
L
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K
L
V
D
A
-
G
N
T
V
I
A
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E
H
K
M
Q
V
V
A
-
A
S
D
W
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L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
-----------------
25
PsiBlast_CBE
61.83
41%
-59
- C2 -
2VF7
5
?
C:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
----
P
Q
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
-
T
D
E
Q
P
-
V
V
P
V
Y
P
GLT
P
A
E
T
Q
-----
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
----
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
-----
A
G
L
---
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
A
E
E
R
E
P
G
H
A
------------
E
R
V
K
N
R
PEQ
A
I
A
L
Q
R
M
A
A
D
L
V
K
----
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
------
R
------
H
T
E
P
---
H
T
P
-
R
---
E
P
A
G
W
L
-
E
L
N
--
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
---------------------------
S
A
R
L
G
G
D
L
-
A
Q
I
T
--
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
-
L
L
------------------------------------------------------------------------------------
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
---
D
E
-----------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
-
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
-----------------
5
PsiBlast_PDB
61.47
41%
-59
- C2 -
2VF8
7
?
A:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
----
P
Q
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
-
T
D
E
Q
P
-
V
V
P
V
Y
PGLT
P
A
E
T
Q
-----
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
----
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
-----
A
G
L
---
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
A
E
E
R
E
P
G
H
A
------------
E
RVKNRP
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
----
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
---------------
E
P
---
H
T
P
-
R
---
E
P
A
G
W
L
-
E
L
N
--
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
-------------------------
G
S
A
R
L
G
G
D
L
-
A
Q
I
T
--
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
------------------------------------------------------------------------------------------
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
---
D
E
-----------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
-
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
-----------------
97
HHSearch
55.41
42%
-75
- C2 -
3PIH
3
UVRA_THEMA
A:
[587-912]
--
Y
A
S
L
K
I
K
G
V
R
H
N
N
L
K
N
I
D
V
E
I
P
L
G
V
F
V
C
V
T
G
V
S
G
S
G
K
S
S
L
V
M
E
T
L
Y
P
A
L
M
N
L
L
H
K
T
----------
K
L
P
A
G
E
F
D
S
I
E
G
HEN
I
D
K
M
I
A
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
K
V
F
D
E
I
R
S
L
F
A
M
T
P
A
---------------------------------------------------
A
K
A
R
------------------------------------------------------------------------------------------
G
Y
N
K
S
R
F
S
F
N
L
K
G
G
R
C
E
A
C
Q
G
Q
G
Y
V
K
I
-
E
M
L
-------------------------
F
L
------------------------------------------------------------------------------------------------------
P
D
V
Y
V
E
C
D
V
C
K
G
K
R
Y
N
R
E
T
L
E
I
T
Y
-----
K
G
K
---
N
I
S
D
I
L
D
M
T
---
V
D
E
A
L
-
E
F
F
K
N
I
P
--------------------------------------
S
I
K
R
T
L
Q
V
L
H
D
V
G
L
G
Y
V
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
I
K
L
A
S
E
L
R
K
R
D
T
G
R
T
L
Y
I
L
D
E
P
T
V
G
L
H
F
E
D
V
R
K
L
V
E
V
L
H
R
L
V
D
R
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
N
A
D
H
I
I
D
L
G
P
E
G
G
K
E
G
G
Y
I
V
A
T
G
T
P
E
E
I
A
K
N
P
H
S
Y
T
G
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
HHSearch
54.98
39%
-73
- C2 -
2R6F
3
?
A:
[628-954]
---
R
W
L
E
V
V
G
A
R
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
L
H
R
A
K
-------
A
K
P
G
E
H
R
D
I
R
G
L
E
H
---
L
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
---------------------------------------------------------------------------------------------------------------------------------------------
V
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
-
E
M
H
-------------------------
F
L
------------------------------------------------------------------------------------------------------
P
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
-----
K
G
K
---
N
I
A
E
V
L
D
M
T
---
V
E
D
A
L
-
D
F
F
A
S
I
P
--------------------------------------
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
HHSearch
50.81
33%
-58
- C2 -
2VF7
3
?
A:
[13-503]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
F
V
Q
V
R
G
A
R
----
Q
----
H
N
L
K
D
I
S
V
K
V
P
R
D
A
L
V
V
F
T
G
V
S
G
S
G
K
S
S
L
A
F
G
T
L
Y
A
E
A
Q
R
R
Y
L
E
-------------
S
V
S
P
Y
ARRLFNQ
A
G
V
P
D
V
D
A
I
-
D
G
L
P
--
P
A
V
A
L
Q
Q
A
R
G
T
P
T
A
R
S
S
V
G
S
V
T
T
L
S
N
L
L
R
M
L
Y
S
R
A
G
D
Y
P
P
GQ
G
I
V
Y
A
E
G
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
SMVPDPSLTIRERAVAAWPQA
W
G
G
Q
N
Q
R
D
I
L
V
T
L
GIDVDVPWRELP
E
E
T
R
H
W
I
L
FTD
E
Q
P
V
V
P
V
Y
P
GLT
P
A
E
T
Q
R
A
L
K
K
KMEPS
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
NTES
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
PYA
E
E
REPGHAERVKNRPE
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
-
F
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
-
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
--------------------
7
PsiBlast_PDB
45.36
45%
-88
- C5 -
4DFC
-
UVRA_ECOLI
B:
[129-248]
-------------------------------------------------------------------------------------------------------------------------------------
A
S
T
V
S
Q
M
V
D
N
V
L
S
Q
P
E
G
K
R
L
M
L
L
A
P
I
I
K
E
R
K
G
E
H
T
K
T
L
E
N
L
A
S
Q
G
Y
I
R
A
R
I
D
G
E
V
C
D
L
S
D
P
P
K
L
E
L
Q
K
K
H
T
I
E
V
V
V
D
R
F
K
V
R
--
L
T
Q
R
L
A
E
S
F
E
T
A
L
E
L
S
G
G
T
A
V
V
A
D
M
D
D
PK
A
E
E
L
L
F
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Fugue
44.65
45%
-80
* C5 *
4DFC
-
UVRA_ECOLI
B:
[128-250]
------------------------------------------------------------------------------------------------------------------------------------
M
A
S
T
V
S
Q
M
V
D
N
V
L
S
Q
P
E
G
K
R
L
M
L
L
A
P
I
I
K
E
R
K
G
E
H
T
K
T
L
E
N
L
A
S
Q
G
Y
I
R
A
R
I
D
G
E
V
C
D
L
S
D
P
P
K
L
E
L
Q
K
K
H
T
I
E
V
V
V
D
R
F
K
V
R
--
L
T
Q
R
L
A
E
S
F
E
T
A
L
E
L
S
G
G
T
A
V
V
A
D
M
D
D
PK
A
E
E
L
L
F
S
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
HHSearch
44.49
21%
-33
- C2 -
3J16
2
RLI1_YEAST
B:
[204-559]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
I
K
I
L
Q
L
E
N
V
-
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
---
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
Q
R
L
N
A
A
Q
I
I
R
S
L
L
A
P
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
Y
G
V
P
S
V
Y
-
G
V
V
T
L
P
A
S
V
R
E
G
I
N
I
---
F
L
D
G
H
I
P
A
E
NLRFRT
E
------
A
L
Q
F
RI-
A
D
A
T
E
DLQ
N
D
S
A
S
R
-
A
F
S
Y
P
S
L
K
K
T
QG
D
----
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
-----------------------------------
L
K
P
D
E
G
Q
-
D
-
I
P
K
L
N
V
S
M
K
P
Q
K
I
-------------------
A
P
K
------------------
F
P
--------------
G
-----------------------------------------------------------------------------------------------------------------------------------------------------
T
V
R
Q
L
F
F
K
K
I
R
G
Q
---
F
L
---
N
--------------------------
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
D
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
G
I
----
P
S
K
N
A
H
A
R
A
P
E
S
L
L
T
-------------------------------
99
HHSearch
42.78
25%
-44
- C2 -
3BK7
2
?
A:
[211-546]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
K
E
L
E
L
E
N
V
-
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
---
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
G
K
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
Y
G
E
P
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
G
I
N
----
E
F
L
Q
G
Y
L
K
D
E
------
N
VRFRP
Y
E
I
R
F
TKL
S
E
R
-
V
---
D
V
E
R
E
T
-
L
V
E
Y
P
R
L
V
----
K
D
YGS
F
K
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
-----------------------------------
E
E
P
T
E
G
K
---------
V
E
W
D
L
T
-
V
---------
A
------------------------
Y
K
P
Q
Y
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
Y
E
G
T
V
Y
E
L
L
S
K
I
D
---
S
S
K
L
---------------------
N
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
-
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
----------------------------------------------------