@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu00090: (2016-06-01 )
MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNIPVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFLTPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKEELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIHGRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNIIAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKHGKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMGSVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKDLRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS
Atome Classification :
(52 SA)
.........10........20.....--...30.....-------...40........50........60........70........80........--90........100.......110.......120......-.130.......140......-.150......-.-160.........170.......180.......190.......200.......210.....-..220........230.......240.......250.......260.......270-.......280.......290.......300.......310.......320.......330.------......340.......350.......360.......370.......380.......390......--.400---...--------....-..---410-........420.......430.......440.......450....-----..-----.460.......470.......480......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MWESKFSKEGLTFD
D
V
L
LVPAKSEVL--PRDV
D
L
S
V
E
L
-------
T
K
T
L
K
LNI
P
V
I
SA
G
M
D
T
V
T
E
S
A
M
A
I
A
M
ARQG
G
L
G
I
I
HKNM
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
SERGVITN
P
F
F
LTPDHQVF
D
A
E
H
L
M
GKYRISG
V
P
IVNN-EED
Q
K
L
V
G
I
I
TNRD
L
R
F
I
S
D-YS
M
K
I
S
D
V
M
T
-
K
-
E
--
E
L
VTASVGT
T
L
D
E
A
E
K
I
L
Q
KHKIEKLPLVDD
Q
N
KL
K
G
L
I
T
I
K
D
I
E
K
V
IEFPNSSKDI-H
G
R
-
L
I
V
G
A
AVGVTG
D
T
M
T
R
V
K
K
L
V
EANV
D
V
I
V
I
DTAHGHSQ
G
V
L
N
T
V
T
K
I
R
E
TYP-E
L
N
I
I
AGNV
A
T
A
E
A
T
R
A
L
I
EAGA
D
V
V
K
VGIGPG
S
I
C
T
T
R
V
V
AGVGVPQ
I
T
A
I
Y
D
C
A
T
E
A
R
K------HG
K
T
I
I
ADG
G
I
K
FSG
D
I
T
K
A
L
AAGG
H
A
V
M
L
G
S
L
LAGTSESPGETEIYQG
R
R
F
K
V
Y
RGMG
S
V
A
A
M
E--KG-----SKD--------R
Y
F
Q
-
E
E---NK--KFVPEGIEGRTPYKG
P
V
E
E
T
V
Y
Q
L
V
G
G
L
R
S
G
MGYCG
S
K
D
L
R
A
L
R
E
-----
E
A
-----
Q
F
I
RMTGAGLRESHPH
D
V
Q
I
TKESPNYTIS
1
PsiBlast_PDB
96.49
80%
-84
- C2 -
3TSB
2
?
A:
[25-510]
M
W
E
S
K
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
--
P
R
E
V
S
V
K
T
V
L
-------
S
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
N
N
-
L
D
E
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
-
Y
S
I
K
I
S
D
V
M
T
-
K
-
E
--
Q
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
D
K
-
Q
G
R
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
--
K
G
-----
S
K
D
--------
R
Y
F
Q
-
E
G
---
N
K
--
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
S
--
106
HHSearch
92.01
69%
-102
- C- -
1ZFJ
1
IMDH_STRPY
A:
[3-491]
-
W
D
T
K
F
L
K
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
L
--
P
N
E
V
D
L
K
T
K
L
-------
A
D
N
L
T
L
N
I
P
I
I
T
A
A
M
D
T
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
N
M
S
I
T
E
Q
A
E
E
V
R
K
V
K
--
R
S
E
N
G
V
I
I
D
P
F
F
L
T
P
E
H
K
V
S
E
A
E
E
L
M
Q
R
Y
R
I
S
G
V
P
I
V
E
T
-
L
A
N
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
S
D
-
Y
N
A
P
I
S
E
H
M
T
---
S
E-
H
L
V
T
A
A
V
G
T
D
L
E
T
A
E
R
I
L
H
E
H
R
I
E
K
L
P
L
V
D
N
S
G
R
L
S
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
H
A
A
K
D
E
-
F
G
R
-
L
L
V
A
A
A
V
G
V
T
S
D
T
F
E
R
A
E
A
L
F
E
A
G
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
P
-
N
R
T
L
I
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
------
Y
G
K
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
Q
G
R
K
Y
K
T
Y
R
G
M
G
S
I
A
A
M
K
--
K
----------------------------
N
--
K
L
V
P
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
Q
E
L
H
E
-----
N
A
-----
Q
F
V
E
M
S
G
A
G
L
I
E
S
H
P
H
D
V
Q
I
T
N
E
A
P
N
Y
S
V
-
4
PsiBlast_PDB
91.34
66%
-101
- C- -
1ZFJ
1
IMDH_STRPY
A:
[3-491]
-
W
D
T
K
F
L
K
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
L
--
P
N
E
V
D
L
K
T
K
L
-------
A
D
N
L
T
L
N
I
P
I
I
T
A
A
M
D
T
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
N
M
S
I
T
E
Q
A
E
E
V
R
K
V
K
--
R
S
E
N
G
V
I
I
D
P
F
F
L
T
P
E
H
K
V
S
E
A
E
E
L
M
Q
R
Y
R
I
S
G
V
P
I
V
E
T
-
L
A
N
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
S
D
-
Y
N
A
P
I
S
E
H
M
T
-
S
-
E
--
H
L
V
T
A
A
V
G
T
D
L
E
T
A
E
R
I
L
H
E
H
R
I
E
K
L
P
L
V
D
N
S
G
R
L
S
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
H
A
A
K
D
E
-
F
G
R
-
L
L
V
A
A
A
V
G
V
T
S
D
T
F
E
R
A
E
A
L
F
E
A
G
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
P
-
N
R
T
L
I
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
------
Y
G
K
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
Q
G
R
K
Y
K
T
Y
R
G
M
G
S
I
A
A
M
K
--
K
----------------------------
N
--
K
L
V
P
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
Q
E
L
H
E
-----
N
A
-----
Q
F
V
E
M
S
G
A
G
L
I
E
S
H
P
H
D
V
Q
I
T
N
E
A
P
N
Y
S
V
-
105
HHSearch
90.65
80%
-95
- C2 -
3USB
4
?
A:
[25-493]
M
W
E
S
K
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
--
P
R
E
V
S
V
K
T
V
L
-------
S
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
N
N
-
L
D
E
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
-
Y
S
I
K
I
S
D
V
M
T
---
K
E
-
Q
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
D
K
-
Q
G
R
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
-------------------------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
-------------------
2
PsiBlast_PDB
90.59
80%
-92
- C2 -
3TSD
1
?
A:
[25-497]
M
W
E
S
K
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
--
P
R
E
V
S
V
K
T
V
L
-------
S
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
N
N
-
L
D
E
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
-
Y
S
I
K
I
S
D
V
M
--
K
-
E
--
Q
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
D
K
-
Q
G
R
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
------
R
Q
F
K
V
Y
R
G
-------------------------------------------------
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
---------------
3
PsiBlast_PDB
89.78
77%
-95
- C2 -
3USB
4
?
A:
[26-493]
-
W
E
S
K
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
--
P
R
E
V
S
V
K
T
V
L
-------
S
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
N
N
-
L
D
E
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
-
Y
S
I
K
I
S
D
V
M
T
-
K
-
E
--
Q
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
D
K
-
Q
G
R
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
-------------------------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
-------------------
114
HHSearch
88.42
57%
-86
- C2 -
4FXS
3
?
A:
[4-486]
---
L
R
I
A
K
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
--
P
N
T
A
D
L
R
T
R
L
-------
T
K
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
V
H
Q
V
K
--
I
F
E
A
--
V
T
H
P
V
T
V
R
P
E
Q
T
I
A
D
V
M
E
L
T
H
Y
H
G
F
A
G
F
P
V
V
T
E
--
N
-
N
E
L
V
G
I
I
T
G
R
D
V
R
F
V
T
D
-
L
T
K
S
V
A
A
V
M
T
---
P
KE
R
L
A
T
V
K
E
G
----
E
V
Q
E
K
M
H
---
V
E
K
I
L
V
V
N
D
E
F
Q
L
K
G
M
I
T
A
K
-----
E
S
K
P
N
A
C
K
D
E
-
Q
G
R
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
--
K
G
-----
S
S
D
--------
R
Y
F
Q
-
T
----
A
D
--
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
6
PsiBlast_PDB
87.78
55%
-85
- C2 -
4FXS
3
?
A:
[5-486]
----
R
I
A
K
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
--
P
N
T
A
D
L
R
T
R
L
-------
T
K
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
V
H
Q
V
K
--
I
F
E
A
--
V
T
H
P
V
T
V
R
P
E
Q
T
I
A
D
V
M
E
L
T
H
Y
H
G
F
A
G
F
P
V
V
T
---
E
N
N
E
L
V
G
I
I
T
G
R
D
V
R
F
V
T
D
-
L
T
K
S
V
A
A
V
M
T
P
K
-
E
--
R
L
A
T
V
K
E
G
----
E
V
Q
E
K
M
H
---
V
E
K
I
L
V
V
N
D
E
F
Q
L
K
G
M
I
T
A
K
-----
E
S
K
P
N
A
C
K
D
E
-
Q
G
R
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
--
K
G
-----
S
S
D
--------
R
Y
F
Q
-
T
------A
D
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
118
HHSearch
83.68
79%
-95
- C2 -
4MYA
4
?
A:
[30-382]
-----
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
--
P
R
E
V
S
V
K
T
V
L
-------
S
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
-----------------------------
K
R
----------
S
-----------------------------------
G
--
G
------------------------
L
-------------------------------------
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
--
K
----------------------------
K
--
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
---
81
PsiBlast_CBE
80.68
41%
-83
- C2 -
4Z87
8
?
B:
[30-494]
L
M
D
S
K
-
T
R
G
G
L
T
Y
N
D
F
L
V
L
P
G
K
I
D
F
P
--
S
S
E
V
V
L
S
S
R
L
-------
T
K
K
I
T
L
N
A
P
F
V
S
S
P
M
D
T
V
T
E
A
D
M
A
I
H
M
A
L
L
G
G
I
G
I
I
H
H
N
C
T
A
E
E
Q
A
E
M
V
R
R
V
K
--
K
Y
E
N
G
F
I
N
A
P
V
V
V
G
P
D
A
T
V
A
D
V
R
R
M
K
N
E
F
G
F
A
G
F
P
V
T
D
D
G
K
P
T
G
K
L
Q
G
I
I
T
S
R
D
I
Q
F
V
E
D
-
E
T
L
L
V
S
E
I
M
T
-
K
-
D
---
V
I
T
G
K
Q
G
I
N
L
E
E
A
N
Q
I
L
K
N
T
K
K
G
K
L
P
I
V
D
E
A
G
C
L
V
S
M
L
S
R
T
D
L
M
K
N
Q
S
Y
P
L
A
S
K
S
A
-
D
T
K
Q
L
L
C
G
A
A
I
G
T
I
D
A
D
R
Q
R
L
A
M
L
V
E
A
G
L
D
V
V
V
L
D
S
S
Q
G
N
S
V
F
Q
I
N
M
I
K
W
I
K
E
T
F
P
-
D
L
Q
V
I
A
G
N
V
V
T
R
E
Q
A
A
S
L
I
H
A
G
A
D
G
L
R
I
G
M
G
S
G
S
I
C
I
T
Q
E
V
M
A
C
G
R
P
Q
G
T
A
V
Y
N
V
T
Q
F
A
N
Q
------
F
G
V
P
C
I
A
D
G
G
V
Q
N
I
G
H
I
T
K
A
I
A
L
G
A
S
T
V
M
M
G
G
M
L
A
G
T
T
E
S
P
G
E
Y
F
F
R
D
G
K
R
L
K
T
Y
R
G
M
G
S
I
D
A
M
Q
------------------------------------
V
A
Q
G
V
T
G
S
V
I
D
K
G
S
I
K
K
Y
I
P
Y
L
Y
N
G
L
Q
H
S
C
Q
D
I
G
V
R
S
L
V
E
F
R
E
-----
K
------------------------------------
9
PsiBlast_PDB
80.49
55%
-92
- C2 -
4DQW
7
?
A:
[23-486]
----
R
I
S
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
--
P
K
D
V
S
L
K
T
R
L
-------
T
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
--
K
H
E
T
A
I
V
R
D
P
V
T
V
T
P
S
T
K
I
I
E
L
L
Q
M
A
R
E
Y
G
F
S
G
F
P
V
V
----
E
Q
G
E
L
V
G
I
V
T
G
R
D
L
R
V
K
P
N
-
A
G
D
T
V
A
A
I
M
T
P
K
-
D
--
K
L
V
T
A
R
E
G
T
P
L
E
E
M
K
A
K
L
Y
E
N
R
I
E
K
M
L
V
V
D
E
N
F
Y
L
R
G
L
V
T
F
R
D
I
E
K
A
K
T
Y
P
L
A
S
K
D
E
-
Q
G
R
-
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
-------------------------------------------------------------------
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
-----
Q
F
V
R
I
T
G
-----------------------
121
HHSearch
80.38
65%
-90
- C2 -
4Q32
3
?
A:
[9-360]
-------
K
T
A
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
L
--
P
N
E
V
S
L
K
T
Q
L
-------
T
K
K
I
Q
L
N
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
N
M
T
I
E
D
Q
A
R
E
V
D
-----------------------------
R
V
K
R
S
--
G
G
---------------------------------------------------------------------
L
L
C
-------------------------------------
G
A
S
I
G
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
K
V
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
P
-
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
L
T
A
V
M
D
C
A
E
E
G
K
K
------
L
G
I
P
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
E
I
Y
Q
G
R
S
Y
K
V
Y
R
G
M
G
S
L
G
A
M
A
------------------------------------
V
P
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
E
N
L
Y
E
-----
N
A
-----
N
F
V
V
Q
T
S
A
G
F
R
E
S
H
P
H
D
I
N
I
T
K
E
A
P
N
Y
S
--
21
PsiBlast_CBE
80.04
55%
-96
- C2 -
4DQW
5
?
B:
[23-486]
----
R
I
S
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
--
P
K
D
V
S
L
K
T
R
L
-------
T
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
--
K
H
E
T
A
I
V
R
D
P
V
T
V
T
P
S
T
K
I
I
E
L
L
Q
M
A
R
E
Y
G
F
S
G
F
P
V
V
----
E
Q
G
E
L
V
G
I
V
T
G
R
D
L
R
V
------
D
T
V
A
A
I
M
T
P
K
-
D
--
K
L
V
T
A
R
E
G
T
P
L
E
E
M
K
A
K
L
Y
E
N
R
I
E
K
M
L
V
V
D
E
N
F
Y
L
R
G
L
V
T
F
R
D
I
E
K
A
K
T
Y
P
L
A
S
K
D
E
-
Q
G
R
-
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
-------------------------------------------------------------------------
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
-----
Q
F
V
R
I
T
G
-----------------------
117
HHSearch
79.91
62%
-93
- C2 -
4X3Z
4
?
A:
[6-363]
--
M
L
R
I
A
K
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
--
P
N
T
A
D
L
R
T
R
L
-------
T
K
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
V
-----------------------------
H
Q
V
K
I
--
S
G
G
---------------------------------------------------------------------
L
R
V
-----------------------------------
G
--
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
-----------------------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
122
HHSearch
79.12
58%
-84
- C2 -
4R7J
8
?
A:
[3-381]
--
A
M
K
I
V
K
R
A
L
T
F
E
D
V
L
L
R
P
G
Y
S
E
V
L
--
P
K
E
V
K
I
H
T
K
L
-------
T
K
N
I
T
L
N
M
P
L
I
S
A
A
M
D
T
V
T
E
H
R
A
A
I
M
M
A
R
L
G
G
L
G
V
I
H
K
N
M
D
I
A
S
Q
V
R
E
V
K
R
V
K
--
K
------
S
E
--------------------------
K
K
R
K
--------------------------------------
E
Y
----
P
-----
D
----
A
N
K
D
N
F
G
R
L
-------------------------------------
R
V
G
A
A
I
G
V
G
--
Q
M
D
R
V
D
A
L
V
E
A
G
V
D
V
V
V
L
D
S
A
H
G
H
S
K
G
I
I
D
T
V
K
A
I
K
A
K
Y
P
-
N
L
D
L
I
A
G
N
I
A
T
A
A
A
A
K
A
L
C
E
A
G
V
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
S
G
V
G
V
P
Q
I
S
A
I
D
E
C
V
E
E
A
N
K
------
F
G
V
P
V
I
A
D
G
G
I
K
Y
S
G
D
I
A
K
A
L
A
V
G
A
S
S
V
M
I
G
S
L
L
A
G
T
D
E
S
P
G
E
L
F
T
Y
Q
G
R
Q
Y
K
S
Y
R
G
M
G
S
L
G
A
M
Q
--
K
--------------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
V
G
S
I
R
S
V
V
H
Q
L
L
G
G
L
R
S
S
M
G
Y
V
G
A
K
D
I
E
D
F
Q
K
-----
R
A
-----
E
F
V
E
I
T
T
A
G
L
K
E
S
H
V
H
D
V
T
I
T
H
E
A
P
N
Y
K
--
69
PsiBlast_CBE
76.39
41%
-79
- C2 -
1JR1
3
IMDH2_CRIGR
A:
[28-507]
--------
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
--
A
D
Q
V
D
L
T
S
A
L
-------
T
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
G
F
I
T
D
P
V
V
----
D
R
V
R
--
F
E
A
K
---------------
M
G
S
R
L
V
---------------------
I
M
T
-
K
R
E
--
D
L
V
V
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
---
K
L
P
I
V
N
E
N
D
E
L
V
A
I
I
A
R
T
D
L
K
K
N
R
D
Y
P
L
A
S
K
D
A
-
K
K
Q
-
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
L
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
M
K
E
K
Y
P
-
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
C
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
G
S
L
D
A
M
-----------------------------------
I
K
V
A
Q
G
V
S
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
S
G
E
L
-----
K
F
E
K
R
T
S
S
A
Q
V
E
G
G
V
H
S
L
H
-----------
65
PsiBlast_CBE
76.11
41%
-82
- C2 -
1NF7
3
IMDH2_HUMAN
A:
[28-507]
--------
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
--
A
D
Q
V
D
L
T
S
A
L
-------
T
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
K
-------------------------------
G
I
I
S
S
R
D
I
D
F
L
--E
H
D
C
F
L
E
E
I
M
T
-
K
R
E
--
D
L
V
V
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
I
V
N
E
D
D
E
L
V
A
I
I
A
R
T
-
L
K
K
N
R
D
Y
P
L
A
S
K
D
A
-
K
K
Q
-
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
-
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
G
S
L
D
A
M
-----------------------------------
I
K
V
A
Q
G
V
S
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
S
G
E
L
-----
K
F
E
K
R
T
S
S
A
Q
V
E
G
G
V
H
S
L
H
-----------
64
PsiBlast_CBE
75.87
41%
-83
- C2 -
1NF7
2
IMDH2_HUMAN
B:
[28-507]
--------
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
--
A
D
Q
V
D
L
T
S
A
L
-------
T
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
K
-------------------------------
G
I
I
S
S
R
D
I
D
F
L
--E
H
D
C
F
L
E
E
I
M
T
-
K
R
E
--
D
L
V
V
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
I
V
N
E
D
D
E
L
V
A
I
I
A
R
T
-
L
K
K
N
R
D
Y
P
L
A
S
K
D
A
-
K
K
Q
-
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
-
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
G
S
L
D
A
M
-----------------------------------
I
K
V
A
Q
G
V
S
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
MMYSG
E
L
-----
K
F
E
K
R
T
S
S
A
Q
V
E
G
G
V
H
S
L
H
-----------
109
HHSearch
75.18
51%
-79
- C2 -
2CU0
1
IMDH_PYRHO
A:
[8-480]
---
L
E
K
A
I
K
G
Y
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
E
--
P
K
D
V
D
V
S
T
R
I
-------
T
P
N
V
K
L
N
I
P
I
L
S
A
A
M
D
T
V
T
E
W
E
M
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
N
M
G
I
E
E
Q
V
E
Q
V
K
R
V
K
--
R
A
E
--------------------------------------------------------------------------------------------------------------------------
K
Y
K
N
A
V
R
D
E
-
N
G
E
-
L
L
V
A
A
A
V
--
S
P
F
D
I
K
R
A
I
E
L
D
K
A
G
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
Q
K
V
--
D
A
D
F
I
V
G
N
I
A
N
P
K
A
V
D
D
L
--
T
F
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
V
A
M
V
A
D
R
A
Q
E
------
Y
G
L
Y
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
M
L
G
N
L
L
A
G
T
K
E
A
P
G
K
E
V
I
I
N
G
R
K
Y
K
Q
Y
R
G
M
G
S
L
G
A
M
M
--
K
------------------------YMK
T
R
--
K
F
V
P
E
G
V
E
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
V
G
G
L
K
A
G
M
G
Y
V
G
A
R
N
I
R
E
L
K
E
-----
K
G
-----
E
F
V
I
I
T
H
A
G
I
K
E
S
H
P
H
D
I
I
I
T
N
E
A
P
N
----
113
HHSearch
74.86
61%
-85
- C2 -
1VRD
-
?
A:
[2-457]
-------
K
E
A
L
T
F
D
D
V
L
L
V
P
Q
Y
S
E
V
L
--
P
K
D
V
K
I
D
T
R
L
-------
T
R
Q
I
R
I
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
A
L
A
K
A
L
A
R
E
G
G
I
G
I
I
H
K
N
L
T
P
D
E
Q
A
R
Q
V
S
I
V
K
--
K
T
----------------------------------------------------------------------------------------------------------------------
I
M
S
V
I
E
H
P
N
A
A
R
D
E
-
K
G
R
-
L
L
V
G
A
A
V
G
T
S
P
E
T
M
E
R
V
E
K
L
V
K
A
G
V
D
V
I
V
I
D
T
A
H
G
H
S
R
R
V
I
E
T
L
E
M
I
K
A
D
Y
P
-
D
L
P
V
V
A
G
N
V
A
T
P
E
G
T
E
A
L
I
K
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
M
E
C
S
E
V
A
R
K
------
Y
D
V
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
L
A
A
G
A
E
S
V
M
V
G
S
I
F
A
G
T
E
E
A
P
G
E
T
I
L
Y
Q
G
R
K
Y
K
A
Y
R
G
M
G
----------------------------------------------
I
E
G
M
V
P
Y
K
G
T
V
K
D
V
V
H
Q
L
V
G
G
L
R
S
G
M
G
Y
I
G
A
R
T
I
K
E
L
Q
E
-----
K
A
-----
V
F
V
K
I
T
------------------------
12
PsiBlast_PDB
74.67
50%
-78
- C2 -
2CU0
1
IMDH_PYRHO
A:
[13-480]
--------
K
G
Y
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
E
--
P
K
D
V
D
V
S
T
R
I
-------
T
P
N
V
K
L
N
I
P
I
L
S
A
A
M
D
T
V
T
E
W
E
M
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
N
M
G
I
E
E
Q
V
E
Q
V
K
R
V
K
--
R
A
E
--------------------------------------------------------------------------------------------------------------------------
K
Y
K
N
A
V
R
D
E
-
N
G
E
-
L
L
V
A
A
A
V
--
S
P
F
D
I
K
R
A
I
E
L
D
K
A
G
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
Q
K
V
--
D
A
D
F
I
V
G
N
I
A
N
P
K
A
V
D
D
L
--
T
F
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
V
A
M
V
A
D
R
A
Q
E
------
Y
G
L
Y
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
M
L
G
N
L
L
A
G
T
K
E
A
P
G
K
E
V
I
I
N
G
R
K
Y
K
Q
Y
R
G
M
G
S
L
G
A
M
M
--
K
---------------------Y
M
K
---
T
R
--
K
F
V
P
E
G
V
E
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
V
G
G
L
K
A
G
M
G
Y
V
G
A
R
N
I
R
E
L
K
E
-----
K
G
-----
E
F
V
I
I
T
H
A
G
I
K
E
S
H
P
H
D
I
I
I
T
N
E
A
P
N
----
123
HHSearch
73.83
56%
-86
- C2 -
4ZQM
2
IMDH_MYCTU
A:
[42-387]
----
K
V
A
M
L
G
L
T
F
D
D
V
L
L
L
P
A
A
S
D
V
V
--
P
A
T
A
D
T
S
S
Q
L
-------
T
K
K
I
R
L
K
V
P
L
V
S
S
A
M
D
T
V
T
E
S
R
M
A
I
A
M
A
R
A
G
G
M
G
V
L
H
R
N
L
P
V
A
E
Q
A
G
-----------------------------
Q
V
E
M
V
K
R
----------
S
-----------------------------------
G
--
G
------------------------
L
L
V
--------
G
-----------------------------
A
A
V
G
V
G
G
D
A
W
V
R
A
M
M
L
V
D
A
G
V
D
V
L
V
V
D
T
A
H
A
H
N
R
L
V
L
D
M
V
G
K
L
K
S
E
V
G
D
R
V
E
V
V
G
G
N
V
A
T
R
S
A
A
A
A
L
V
D
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
A
P
Q
I
T
A
I
L
E
A
V
A
A
C
R
P
------
A
G
V
P
V
I
A
D
G
G
L
Q
Y
S
G
D
I
A
K
A
L
A
A
G
A
S
T
A
M
L
G
S
L
L
A
G
T
A
E
A
P
G
E
L
I
F
V
N
G
K
Q
Y
K
S
Y
R
G
M
G
S
L
G
A
M
------------------------------------
L
V
P
E
G
I
E
G
R
V
P
F
R
G
P
L
S
S
V
I
H
Q
L
T
G
G
L
R
A
A
M
G
Y
T
G
S
P
T
I
E
V
L
Q
------
Q
A
-----
Q
F
V
R
I
T
P
A
G
L
--------------------
112
HHSearch
73.34
42%
-76
- C2 -
4AF0
2
?
A:
[55-537]
-----
R
K
N
G
G
L
T
Y
N
D
F
L
V
L
P
G
H
I
N
F
P
--
A
S
D
V
S
L
Q
S
K
A
-------
T
K
N
I
V
L
N
T
P
F
L
S
S
P
M
D
T
V
T
E
D
R
M
A
I
A
L
A
L
H
G
G
L
G
I
I
H
H
N
C
S
A
E
E
Q
A
A
M
V
R
R
V
K
--
K
Y
E
N
--------------------------------------------------------------------------------------------------------------------------
Y
P
Y
A
S
K
V
P
E
S
K
Q
-
L
Y
C
G
A
A
I
G
T
R
P
G
D
K
D
R
L
K
L
L
A
E
A
G
L
D
V
V
V
L
D
S
S
Q
G
N
S
V
Y
Q
I
E
F
I
K
W
I
K
Q
T
Y
P
-
K
I
D
V
I
A
G
N
V
V
T
R
E
Q
A
A
Q
L
I
A
A
G
A
D
G
L
R
I
G
M
G
S
G
S
I
C
I
T
Q
E
V
M
A
V
G
R
P
Q
G
T
A
V
Y
A
V
A
E
F
A
S
R
------
F
G
I
P
C
I
A
D
G
G
I
G
N
I
G
H
I
A
K
A
L
A
L
G
A
S
A
V
M
M
G
G
L
L
A
G
T
T
E
S
P
G
E
Y
F
Y
H
E
G
K
R
V
K
V
Y
R
G
M
G
S
I
E
A
M
E
--
H
T
GLDNA
A
T
A
--------
R
Y
F
S
-
E
A
---
D
A
--
V
K
V
A
Q
G
V
S
G
D
V
A
D
K
G
S
I
N
K
F
V
P
Y
L
F
T
G
L
Q
H
S
L
Q
D
A
A
I
K
S
V
S
E
L
H
S
-----
C
A
R
S
GS
L
R
F
E
L
R
T
A
S
----------------------
82
PsiBlast_CBE
72.83
43%
-80
- C2 -
4AF0
2
?
B:
[59-525]
---------
G
L
T
Y
N
D
F
L
V
L
P
G
H
I
N
F
P
--
A
S
D
V
S
L
Q
S
K
A
-------
T
K
N
I
V
L
N
T
P
F
L
S
S
P
M
D
T
V
T
E
D
R
M
A
I
A
L
A
L
H
G
G
L
G
I
I
H
H
N
C
S
A
E
E
Q
A
A
M
V
R
R
V
K
--
K
Y
E
N
--------------------------------------------------------------------------------------------------------------------------
Y
P
Y
A
S
K
V
P
-
E
S
K
Q
L
Y
C
G
A
A
I
G
T
R
P
G
D
K
D
R
L
K
L
L
A
E
A
G
L
D
V
V
V
L
D
S
S
Q
G
N
S
V
Y
Q
I
E
F
I
K
W
I
K
Q
T
Y
P
-
K
I
D
V
I
A
G
N
V
V
T
R
E
Q
A
A
Q
L
I
A
A
G
A
D
G
L
R
I
G
M
G
S
G
S
I
C
I
T
Q
E
V
M
A
V
G
R
P
Q
G
T
A
V
Y
A
V
A
E
F
A
S
R
------
F
G
I
P
C
I
A
D
G
G
I
G
N
I
G
H
I
A
K
A
L
A
L
G
A
S
A
V
M
M
G
G
L
L
A
G
T
T
E
S
P
G
E
Y
F
Y
H
E
G
K
R
V
K
V
Y
R
G
M
G
S
I
E
A
M
E
HT----------GLDNAATA
R
Y
F
S
-
E
A
---
D
A
--
V
K
V
A
Q
G
V
S
G
D
V
A
D
K
G
S
I
N
K
F
V
P
Y
L
F
T
G
L
Q
H
S
L
Q
D
A
G
I
K
S
V
S
E
L
H
S
-----
C
A
-----
R
-----------------------------
68
PsiBlast_CBE
72.48
41%
-81
- C2 -
1JR1
3
IMDH2_CRIGR
B:
[28-507]
--------
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
--
A
D
Q
V
D
L
T
S
A
L
-------
T
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
--------------------------------------------------------------------------------------------------------------------------
Y
P
L
A
S
K
D
A
-
K
K
Q
-
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
L
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
M
K
E
K
Y
P
-
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
C
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
G
S
L
D
A
M
-----------------------------------
I
K
V
A
Q
G
V
S
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
S
G
E
L
-----
K
F
E
K
R
T
S
S
A
Q
V
E
G
G
V
H
S
L
H
-----------
83
PsiBlast_CBE
72.20
43%
-83
- C2 -
4AF0
2
?
A:
[59-509]
---------
G
L
T
Y
N
D
F
L
V
L
P
G
H
I
N
F
P
--
A
S
D
V
S
L
Q
S
K
A
-------
T
K
N
I
V
L
N
T
P
F
L
S
S
P
M
D
T
V
T
E
D
R
M
A
I
A
L
A
L
H
G
G
L
G
I
I
H
H
N
C
S
A
E
E
Q
A
A
M
V
R
R
V
K
--
K
Y
E
N
--------------------------------------------------------------------------------------------------------------------------
Y
P
Y
A
S
K
V
P
-
E
S
K
Q
L
Y
C
G
A
A
I
G
T
R
P
G
D
K
D
R
L
K
L
L
A
E
A
G
L
D
V
V
V
L
D
S
S
Q
G
N
S
V
Y
Q
I
E
F
I
K
W
I
K
Q
T
Y
P
-
K
I
D
V
I
A
G
N
V
V
T
R
E
Q
A
A
Q
L
I
A
A
G
A
D
G
L
R
I
G
M
G
S
G
S
I
C
I
T
Q
E
V
M
A
V
G
R
P
Q
G
T
A
V
Y
A
V
A
E
F
A
S
R
------
F
G
I
P
C
I
A
D
G
G
I
G
N
I
G
H
I
A
K
A
L
A
L
G
A
S
A
V
M
M
G
G
L
L
A
G
T
T
E
S
P
G
E
Y
F
Y
H
E
G
K
R
V
K
V
Y
R
G
M
G
S
I
E
A
M
E
HT----------GLDNAATA
R
Y
F
S
-
E
A
---
D
A
--
V
K
V
A
Q
G
V
S
G
D
V
A
D
K
G
S
I
N
K
F
V
P
Y
L
F
T
G
L
Q
H
S
L
-------------------------------------------------------
108
HHSearch
72.12
56%
-93
- C2 -
5AHN
2
?
A:
[3-467]
----
R
I
S
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
--
P
K
D
V
S
L
K
T
R
L
-------
T
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
--
K
H
---------------------------------------------------------------------------------------------------------------------------
T
Y
P
L
A
S
K
D
E
-
Q
G
R
-
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
-----------------------------------------------------------------------
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
-----
Q
F
V
R
I
T
G
A
----------------------
10
PsiBlast_PDB
71.96
55%
-93
- C2 -
5AHN
2
?
A:
[3-467]
----
R
I
S
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
--
P
K
D
V
S
L
K
T
R
L
-------
T
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
--
K
H
---------------------------------------------------------------------------------------------------------------------------
T
Y
P
L
A
S
K
D
E
-
Q
G
R
-
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
-----------------------------------------------------------------------
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
-----
Q
F
V
R
I
T
G
A
----------------------
63
PsiBlast_CBE
71.34
41%
-85
- C2 -
1NFB
2
IMDH2_HUMAN
A:
[28-498]
--------
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
--
A
D
Q
V
D
L
T
S
A
L
-------
T
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
-----------------
G
I
P
I
T
D
T
G
R
M
G
S
-------------------------------------
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
I
V
N
E
D
D
E
-
V
A
I
I
A
------
N
R
D
Y
P
L
A
S
K
D
A
-
K
K
Q
-
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
-
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
-----------------------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
S
G
E
L
-----
K
F
E
K
R
T
S
S
A
Q
--------------------
62
PsiBlast_CBE
70.97
41%
-83
- C2 -
1NFB
2
IMDH2_HUMAN
B:
[28-498]
--------
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
--
A
D
Q
V
D
L
T
S
A
L
-------
T
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
-----------------
G
I
P
I
T
D
T
G
R
M
G
S
-------------------------------------
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
I
V
N
E
D
D
E
-
V
A
I
I
A
------
N
R
D
Y
P
L
A
S
K
D
A
-
K
K
Q
-
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
-
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
-----------------------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
MMYSG
E
L
-----
K
F
E
K
R
T
S
S
A
Q
--------------------
34
PsiBlast_CBE
70.83
78%
-93
- C2 -
4MYA
3
?
B:
[116-382]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
--
K
-------------------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
---
110
HHSearch
70.67
35%
-77
- C2 -
1ME8
3
IMDH_TRIFO
A:
[5-492]
-----
Y
N
E
P
C
H
T
F
N
E
Y
L
L
I
P
G
L
S
T
V
D
CI
P
S
N
V
N
L
S
T
P
L
V
K
F
Q
KGQ
Q
S
E
I
N
L
K
I
P
L
V
S
A
I
M
Q
S
V
S
G
E
K
M
A
I
A
L
A
R
E
G
G
I
S
F
I
F
G
S
Q
S
I
E
S
Q
A
A
M
V
H
A
V
K
N
F
K
A
-----------------------------------------------------------------------------------------------------------------------------
H
N
E
L
V
D
S
-
Q
K
R
-
Y
L
V
G
A
G
I
N
T
R
-
D
F
R
E
R
V
P
A
L
V
E
A
G
A
D
V
L
C
I
D
S
S
D
G
F
S
E
W
Q
K
I
T
I
G
W
I
R
E
K
Y
G
D
K
V
K
V
G
A
G
N
I
V
D
G
E
G
F
R
Y
L
A
D
A
G
A
D
F
I
K
I
G
I
G
G
G
S
I
C
I
T
R
E
Q
K
G
I
G
R
G
Q
A
T
A
V
I
D
V
V
A
E
R
N
K
Y
F
E
ET
G
I
Y
I
P
V
C
S
D
G
G
I
V
Y
D
Y
H
M
T
L
A
L
A
M
G
A
D
F
I
M
L
G
R
Y
F
A
R
F
E
E
S
P
T
R
K
V
T
I
N
G
S
V
M
K
E
Y
W
G
E
G
S
S
R
A
R
N
--
W
-----------------------------------
E
G
V
D
S
Y
V
P
Y
A
G
K
L
K
D
N
V
E
A
S
L
N
K
V
K
S
T
M
C
N
C
G
A
L
T
I
P
Q
L
Q
S
-----
K
A
-----
K
I
T
L
V
S
S
V
S
I
V
E
G
G
A
H
D
V
I
-----------
15
PsiBlast_PDB
69.47
78%
-90
- C2 -
4MYA
4
?
A:
[116-382]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
--
K
----------------------------
K
--
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
---
26
PsiBlast_CBE
68.82
78%
-96
- C2 -
4QM1
3
?
B:
[116-383]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
--
K
-------------------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
-----
H
V
Q
I
T
K
E
A
P
N
Y
S
--
13
PsiBlast_PDB
68.29
78%
-92
- C2 -
4MY8
9
?
A:
[116-367]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
--
K
G
-----
S
K
------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
------------------
43
PsiBlast_CBE
68.18
78%
-97
- C2 -
4MY8
4
?
C:
[116-366]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
--
K
-------------------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
-------------------
24
PsiBlast_CBE
67.70
78%
-93
- C2 -
4QM1
3
?
D:
[116-376]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
-----------------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
----
V
Q
I
T
---------
80
PsiBlast_CBE
67.21
63%
-81
- C2 -
4FO4
3
?
A:
[93-365]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
S
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
----------------------------------
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
-
44
PsiBlast_CBE
67.17
78%
-92
- C2 -
4MY8
7
?
B:
[116-366]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
--
K
--------------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
-------------------
79
PsiBlast_CBE
66.54
63%
-79
- C2 -
4FO4
3
?
B:
[93-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
S
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
----------------------------------
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
--
25
PsiBlast_CBE
66.50
78%
-95
- C2 -
4QM1
3
?
C:
[116-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
-------------------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
------
V
Q
I
----------
18
PsiBlast_PDB
66.29
78%
-92
- C2 -
4QM1
3
?
A:
[116-376]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
--
K
---------------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
------
V
Q
I
T
---------
70
PsiBlast_CBE
66.27
63%
-82
- C2 -
4X3Z
3
?
B:
[93-365]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
S
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
----------------------------------
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
-
74
PsiBlast_CBE
65.39
63%
-78
- C2 -
4QNE
3
?
A:
[93-365]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
S
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
-----------------------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
-
73
PsiBlast_CBE
65.36
63%
-79
- C2 -
4QNE
3
?
B:
[93-365]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
S
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
-----------------------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
-
71
PsiBlast_CBE
65.28
63%
-80
- C2 -
4X3Z
4
?
A:
[93-363]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
S
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
-----------------------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
77
PsiBlast_CBE
65.03
63%
-79
- C2 -
4IX2
2
?
B:
[93-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
S
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
--------------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
--
78
PsiBlast_CBE
64.39
63%
-82
- C2 -
4IX2
2
?
A:
[93-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
S
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
--------------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
--
75
PsiBlast_CBE
64.33
63%
-86
- C2 -
4IX2
3
?
D:
[93-363]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
S
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
--------------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
76
PsiBlast_CBE
64.28
63%
-82
- C2 -
4IX2
3
?
C:
[93-363]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
S
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
--------------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
100
PsiBlast_CBE
63.82
59%
-80
- C2 -
5AHM
3
?
A:
[113-398]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
K
T
Y
P
L
A
S
K
D
E
-
Q
G
R
-
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
I
E
L
F
Q
G
R
S
Y
K
S
Y
R
G
M
G
S
L
----------------------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
-----
Q
F
V
R
I
T
G
A
G
M
A
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
--
72
PsiBlast_CBE
61.12
63%
-95
- C2 -
4QQ3
3
?
A:
[93-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
S
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
-------
G
R
S
Y
K
A
Y
R
G
M
G
-------------------------------------------------
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
----------------------