@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu11670: (2016-06-18 )
MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTSAAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSEEDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKAAKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNAFLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLESVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILLAPATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI
Atome Classification :
(20 SA)
.........10........20......-.-.30........40........50.-......--.60........70........80........90........100.......110----.------.-----------.....120..-.....------130..-.-....140.......150.......160.......170.......180....-....190.......200.......210...--....220.......230..-.-..-.-.--240---.---.---------......250....---------------...260..---------------...---.--.270.......280.......290.......300.......310.......320.......330.......340.......350.-......360.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
R
H
Y
E
A
V
V
IGG
G
I
I
G
S
A
I
A
Y
Y
L
AKEN-K-N
T
A
L
FESGTMGGR
T
T
S
A
A
AGMLGA-HA
E
C
E
E
--
R
D
A
F
F
D
F
A
M
H
S
Q
R
L
Y
K
G
L
G
E
E
L
YALSG
V
D
I
R
QHNG
G
M
F
K
L
AFS
E
E
D
V
L
Q
L
R
QMD----D------L-----------DSVSWY
S
K
E
E
-
V
L
EKE------PYASG-D-IF
G
A
S
F
IQDDVHV
E
P
Y
F
V
C
K
A
Y
V
K
A
A
K
M
L
G
A
E
I
F
EHT
P
V
L
H
V
ERDG-
E
A
L
F
-
I
KTPSGD
V
W
A
N
H
V
V
V
ASGVW
S
G
M
F
F
K
Q
LGL--NNAFLPVKGE
C
L
S
VWNDDI-P-
L
T
-
K
-
T
--L-Y---H---D---------
H
C
Y
I
V
PRKSG
R
L
V
---------------
V
G
A
TMKPG---------------DWS---E--TPDLG
G
L
E
S
V
M
K
K
A
K
T
M
L
P
A
I
Q
NM
K
V
D
R
F
W
AGLRPGTKDGKPYIGRHPED
S
R
I
L
F
AAGHFRN
G
I
L
LAPA
T
G
A
L
I
S
D
L
I
MNKEV
N
Q
-
D
W
L
H
A
F
RID
R
K
EAVQI
23
PsiBlast_CBE
85.05
99%
-116
- C2 -
1RYI
2
GLOX_BACSU
B:
[14-377]
M
K
R
H
Y
E
A
V
V
I
G
G
G
I
I
G
S
A
I
A
Y
Y
L
A
K
E
N
-
K
-
N
T
A
L
F
E
S
G
T
M
G
G
R
T
T
S
A
A
A
G
M
L
G
A
-
H
A
E
C
E
E
--
R
D
A
F
F
D
F
A
M
H
S
Q
R
L
Y
K
G
L
G
E
E
L
Y
A
L
S
G
V
D
I
R
Q
H
N
G
G
M
F
K
L
A
F
S
E
E
D
V
L
Q
L
R
Q
M
D
----
D
------
L
-----------
D
S
V
S
W
Y
S
K
E
E
-
V
L
E
K
E
------
P
Y
A
S
G
-
D
-
I
F
G
A
S
F
I
Q
D
D
V
H
V
E
P
Y
F
V
C
K
A
Y
V
K
A
A
K
M
L
G
A
E
I
F
E
H
T
P
V
L
H
V
E
R
D
G
-
E
A
L
F
-
I
K
T
P
S
G
D
V
W
A
N
H
V
V
V
A
S
G
V
W
S
G
M
F
F
K
Q
L
G
L
--
N
N
A
F
L
P
V
K
G
E
C
L
S
V
W
N
D
D
I
-
P
-
L
T
-
K
-
T
--
L
-
Y
---
H
---
D
---------
H
C
Y
I
V
P
R
K
S
G
R
L
V
---------------
V
G
A
T
M
K
P
G
---------------
D
W
S
---
E
--
T
P
D
L
G
G
L
E
S
V
M
K
K
A
K
T
M
L
P
A
I
Q
N
M
K
V
D
R
F
W
A
G
L
R
P
G
T
K
D
G
K
P
Y
I
G
R
H
P
E
D
S
R
I
L
F
A
A
G
H
F
R
N
G
I
L
L
A
P
A
T
G
A
L
I
S
D
L
I
M
N
K
E
V
N
Q
-
D
W
L
H
A
F
R
I
D
R
K
-----
22
PsiBlast_CBE
83.17
99%
-113
- C2 -
1RYI
2
GLOX_BACSU
C:
[14-377]
M
K
R
H
Y
E
A
V
V
I
G
G
G
I
I
G
S
A
I
A
Y
Y
L
A
K
E
N
-
K
-
N
T
A
L
F
E
S
G
T
M
G
G
R
T
T
S
A
A
A
G
M
L
G
A
-
H
A
E
C
E
E
--
R
D
A
F
F
D
F
A
M
H
S
Q
R
L
Y
K
G
L
G
E
E
L
Y
A
L
S
G
V
D
I
R
Q
H
N
G
G
M
F
K
L
A
F
S
E
E
D
V
L
Q
L
R
Q
M
D
----
D
------
L
-----------
D
S
V
S
W
Y
S
K
E
E
-
V
L
E
K
E
------
P
Y
A
S
G
-
D
-
I
F
G
A
S
F
I
Q
D
D
V
H
V
E
P
Y
F
V
C
K
A
Y
V
K
A
A
K
M
L
G
A
E
I
F
E
H
T
P
V
L
H
V
E
R
D
G
-
E
A
L
F
-
I
K
T
P
S
G
D
V
W
A
N
H
V
V
V
A
S
G
V
W
S
G
M
F
F
K
Q
L
G
L
--
N
N
A
F
L
P
V
K
G
E
C
L
S
V
W
N
D
D
I
-
P
-
L
T
-
K
-
T
--
L
-
Y
---
H
---
D
---------
H
C
Y
I
V
P
R
K
S
G
R
L
V
---------------
V
G
A
T
M
K
P
G
---------------
D
W
S
---
E
--
T
P
D
L
G
G
L
E
S
V
M
K
K
A
K
T
M
L
P
A
I
Q
N
M
K
V
D
R
F
W
A
G
L
R
P
G
T
K
D
G
K
P
Y
I
G
R
H
P
E
D
S
R
I
L
F
A
A
G
H
F
R
N
G
I
L
L
A
P
A
T
G
A
L
I
S
D
L
I
M
N
K
E
V
N
Q
-
D
W
L
H
A
F
R
I
D
R
K
-----
1
PsiBlast_PDB
83.06
99%
-113
- C2 -
1RYI
2
GLOX_BACSU
A:
[14-377]
M
K
R
H
Y
E
A
V
V
I
G
G
G
I
I
G
S
A
I
A
Y
Y
L
A
K
E
N
-
K
-
N
T
A
L
F
E
S
G
T
M
G
G
R
T
T
S
A
A
A
G
M
L
G
A
-
H
A
E
C
E
E
--
R
D
A
F
F
D
F
A
M
H
S
Q
R
L
Y
K
G
L
G
E
E
L
Y
A
L
S
G
V
D
I
R
Q
H
N
G
G
M
F
K
L
A
F
S
E
E
D
V
L
Q
L
R
Q
M
D
----
D
------
L
-----------
D
S
V
S
W
Y
S
K
E
E
-
V
L
E
K
E
------
P
Y
A
S
G
-
D
-
I
F
G
A
S
F
I
Q
D
D
V
H
V
E
P
Y
F
V
C
K
A
Y
V
K
A
A
K
M
L
G
A
E
I
F
E
H
T
P
V
L
H
V
E
R
D
G
-
E
A
L
F
-
I
K
T
P
S
G
D
V
W
A
N
H
V
V
V
A
S
G
V
W
S
G
M
F
F
K
Q
L
G
L
--
N
N
A
F
L
P
V
K
G
E
C
L
S
V
W
N
D
D
I
-
P
-
L
T
-
K
-
T
--
L
-
Y
---
H
---
D
---------
H
C
Y
I
V
P
R
K
S
G
R
L
V
---------------
V
G
A
T
M
K
P
G
---------------
D
W
S
---
E
--
T
P
D
L
G
G
L
E
S
V
M
K
K
A
K
T
M
L
P
A
I
Q
N
M
K
V
D
R
F
W
A
G
L
R
P
G
T
K
D
G
K
P
Y
I
G
R
H
P
E
D
S
R
I
L
F
A
A
G
H
F
R
N
G
I
L
L
A
P
A
T
G
A
L
I
S
D
L
I
M
N
K
E
V
N
Q
-
D
W
L
H
A
F
R
I
D
R
K
-----
21
PsiBlast_CBE
83.01
99%
-111
- C2 -
1RYI
2
GLOX_BACSU
D:
[14-377]
M
K
R
H
Y
E
A
V
V
I
G
G
G
I
I
G
S
A
I
A
Y
Y
L
A
K
E
N
-
K
-
N
T
A
L
F
E
S
G
T
M
G
G
R
T
T
S
A
A
A
G
M
L
G
A
-
H
A
E
C
E
E
--
R
D
A
F
F
D
F
A
M
H
S
Q
R
L
Y
K
G
L
G
E
E
L
Y
A
L
S
G
V
D
I
R
Q
H
N
G
G
M
F
K
L
A
F
S
E
E
D
V
L
Q
L
R
Q
M
D
----
D
------
L
-----------
D
S
V
S
W
Y
S
K
E
E
-
V
L
E
K
E
------
P
Y
A
S
G
-
D
-
I
F
G
A
S
F
I
Q
D
D
V
H
V
E
P
Y
F
V
C
K
A
Y
V
K
A
A
K
M
L
G
A
E
I
F
E
H
T
P
V
L
H
V
E
R
D
G
-
E
A
L
F
-
I
K
T
P
S
G
D
V
W
A
N
H
V
V
V
A
S
G
V
W
S
G
M
F
F
K
Q
L
G
L
--
N
N
A
F
L
P
V
K
G
E
C
L
S
V
W
N
D
D
I
-
P
-
L
T
-
K
-
T
--
L
-
Y
---
H
---
D
---------
H
C
Y
I
V
P
R
K
S
G
R
L
V
---------------
V
G
A
T
M
K
P
G
---------------
D
W
S
---
E
--
T
P
D
L
G
G
L
E
S
V
M
K
K
A
K
T
M
L
P
A
I
Q
N
M
K
V
D
R
F
W
A
G
L
R
P
G
T
K
D
G
K
P
Y
I
G
R
H
P
E
D
S
R
I
L
F
A
A
G
H
F
R
N
G
I
L
L
A
P
A
T
G
A
L
I
S
D
L
I
M
N
K
E
V
N
Q
-
D
W
L
H
A
F
R
I
D
R
K
-----
4
PsiBlast_PDB
82.77
99%
-115
- C2 -
3IF9
2
GLOX_BACSU
A:
[14-377]
M
K
R
H
Y
E
A
V
V
I
G
G
G
I
I
G
S
A
I
A
Y
Y
L
A
K
E
N
-
K
-
N
T
A
L
F
E
S
G
T
M
G
G
R
T
T
S
A
A
A
G
M
L
S
A
-
H
R
E
C
E
E
--
R
D
A
F
F
D
F
A
M
H
S
Q
R
L
Y
K
G
L
G
E
E
L
Y
A
L
S
G
V
D
I
R
Q
H
N
G
G
M
F
K
L
A
F
S
E
E
D
V
L
Q
L
R
Q
M
D
----
D
------
L
-----------
D
S
V
S
W
Y
S
K
E
E
-
V
L
E
K
E
------
P
Y
A
S
G
-
D
-
I
F
G
A
S
F
I
Q
D
D
V
H
V
E
P
Y
F
V
C
K
A
Y
V
K
A
A
K
M
L
G
A
E
I
F
E
H
T
P
V
L
H
V
E
R
D
G
-
E
A
L
F
-
I
K
T
P
S
G
D
V
W
A
N
H
V
V
V
A
S
G
V
W
S
G
M
F
F
K
Q
L
G
L
--
N
N
A
F
L
P
V
K
G
E
C
L
S
V
W
N
D
D
I
-
P
-
L
T
-
K
-
T
--
L
-
Y
---
H
---
D
---------
A
C
Y
I
V
P
R
K
S
G
R
L
V
---------------
V
G
A
T
M
K
P
G
---------------
D
W
S
---
E
--
T
P
D
L
G
G
L
E
S
V
M
K
K
A
K
T
M
L
P
A
I
Q
N
M
K
V
D
R
F
W
A
G
L
R
P
G
T
K
D
G
K
P
Y
I
G
R
H
P
E
D
S
R
I
L
F
A
A
G
H
F
R
N
G
I
L
L
A
P
A
T
G
A
L
I
S
D
L
I
M
N
K
E
V
N
Q
-
D
W
L
H
A
F
R
I
D
R
K
-----
3
PsiBlast_PDB
82.24
99%
-110
- C2 -
1NG4
3
GLOX_BACSU
A:
[22-385]
M
K
R
H
Y
E
A
V
V
I
G
G
G
I
I
G
S
A
I
A
Y
Y
L
A
K
E
N
-
K
-
N
T
A
L
F
E
S
G
T
M
G
G
R
T
T
S
A
A
A
G
M
L
G
A
-
H
A
E
C
E
E
--
R
D
A
F
F
D
F
A
M
H
S
Q
R
L
Y
K
G
L
G
E
E
L
Y
A
L
S
G
V
D
I
R
Q
H
N
G
G
M
F
K
L
A
F
S
E
E
D
V
L
Q
L
R
Q
M
D
----
D
------
L
-----------
D
S
V
S
W
Y
S
K
E
E
-
V
L
E
K
E
------
P
Y
A
S
G
-
D
-
I
F
G
A
S
F
I
Q
D
D
V
H
V
E
P
Y
F
V
C
K
A
Y
V
K
A
A
K
M
L
G
A
E
I
F
E
H
T
P
V
L
H
V
E
R
D
G
-
E
A
L
F
-
I
K
T
P
S
G
D
V
W
A
N
H
V
V
V
A
S
G
V
W
S
G
M
F
F
K
Q
L
G
L
--
N
N
A
F
L
P
V
K
G
E
C
L
S
V
W
N
D
D
I
-
P
-
L
T
-
K
-
T
--
L
-
Y
---
H
---
D
---------
H
C
Y
I
V
P
R
K
S
G
R
L
V
---------------
V
G
A
T
M
K
P
G
---------------
D
W
S
---
E
--
T
P
D
L
G
G
L
E
S
V
M
K
K
A
K
T
M
L
P
P
I
Q
N
M
K
V
D
R
F
W
A
G
L
R
P
G
T
K
D
G
K
P
Y
I
G
R
H
P
E
D
S
R
I
L
F
A
A
G
H
F
R
N
G
I
L
L
A
P
A
T
G
A
L
I
S
D
L
I
M
N
K
E
V
N
Q
-
D
W
L
H
A
F
R
I
D
R
K
-----
27
PsiBlast_CBE
82.10
99%
-113
- C2 -
3IF9
2
GLOX_BACSU
C:
[14-377]
M
K
R
H
Y
E
A
V
V
I
G
G
G
I
I
G
S
A
I
A
Y
Y
L
A
K
E
N
-
K
-
N
T
A
L
F
E
S
G
T
M
G
G
R
T
T
S
A
A
A
G
M
L
S
A
-
H
R
E
-----
R
D
A
F
F
D
F
A
M
H
S
Q
R
L
Y
K
G
L
G
E
E
L
Y
A
L
S
G
V
D
I
R
Q
H
N
G
G
M
F
K
L
A
F
S
E
E
D
V
L
Q
L
R
Q
M
D
----
D
------
L
-----------
D
S
V
S
W
Y
S
K
E
E
-
V
L
E
K
E
------
P
Y
A
S
G
-
D
-
I
F
G
A
S
F
I
Q
D
D
V
H
V
E
P
Y
F
V
C
K
A
Y
V
K
A
A
K
M
L
G
A
E
I
F
E
H
T
P
V
L
H
V
E
R
D
G
-
E
A
L
F
-
I
K
T
P
S
G
D
V
W
A
N
H
V
V
V
A
S
G
V
W
S
G
M
F
F
K
Q
L
G
L
--
N
N
A
F
L
P
V
K
G
E
C
L
S
V
W
N
D
D
I
-
P
-
L
T
-
K
-
T
--
L
-
Y
---
H
---
D
---------
A
C
Y
I
V
P
R
K
S
G
R
L
V
---------------
V
G
A
T
M
K
P
G
---------------
D
W
S
---
E
--
T
P
D
L
G
G
L
E
S
V
M
K
K
A
K
T
M
L
P
A
I
Q
N
M
K
V
D
R
F
W
A
G
L
R
P
G
T
K
D
G
K
P
Y
I
G
R
H
P
E
D
S
R
I
L
F
A
A
G
H
F
R
N
G
I
L
L
A
P
A
T
G
A
L
I
S
D
L
I
M
N
K
E
V
N
Q
-
D
W
L
H
A
F
R
I
D
R
K
-----
2
PsiBlast_PDB
81.78
99%
-110
- C2 -
1NG3
3
GLOX_BACSU
A:
[22-385]
M
K
R
H
Y
E
A
V
V
I
G
G
G
I
I
G
S
A
I
A
Y
Y
L
A
K
E
N
-
K
-
N
T
A
L
F
E
S
G
T
M
G
G
R
T
T
S
A
A
A
G
M
L
G
A
-
H
A
E
C
E
E
--
R
D
A
F
F
D
F
A
M
H
S
Q
R
L
Y
K
G
L
G
E
E
L
Y
A
L
S
G
V
D
I
R
Q
H
N
G
G
M
F
K
L
A
F
S
E
E
D
V
L
Q
L
R
Q
M
D
----
D
------
L
-----------
D
S
V
S
W
Y
S
K
E
E
-
V
L
E
K
E
------
P
Y
A
S
G
-
D
-
I
F
G
A
S
F
I
Q
D
D
V
H
V
E
P
Y
F
V
C
K
A
Y
V
K
A
A
K
M
L
G
A
E
I
F
E
H
T
P
V
L
H
V
E
R
D
G
-
E
A
L
F
-
I
K
T
P
S
G
D
V
W
A
N
H
V
V
V
A
S
G
V
W
S
G
M
F
F
K
Q
L
G
L
--
N
N
A
F
L
P
V
K
G
E
C
L
S
V
W
N
D
D
I
-
P
-
L
T
-
K
-
T
--
L
-
Y
---
H
---
D
---------
H
C
Y
I
V
P
R
K
S
G
R
L
V
---------------
V
G
A
T
M
K
P
G
---------------
D
W
S
---
E
--
T
P
D
L
G
G
L
E
S
V
M
K
K
A
K
T
M
L
P
P
I
Q
N
M
K
V
D
R
F
W
A
G
L
R
P
G
T
K
D
G
K
P
Y
I
G
R
H
P
E
D
S
R
I
L
F
A
A
G
H
F
R
N
G
I
L
L
A
P
A
T
G
A
L
I
S
D
L
I
M
N
K
E
V
N
Q
-
D
W
L
H
A
F
R
I
D
R
K
-----
24
PsiBlast_CBE
81.71
99%
-110
- C2 -
1NG4
3
GLOX_BACSU
B:
[22-385]
M
K
R
H
Y
E
A
V
V
I
G
G
G
I
I
G
S
A
I
A
Y
Y
L
A
K
E
N
-
K
-
N
T
A
L
F
E
S
G
T
M
G
G
R
T
T
S
A
A
A
G
M
L
G
A
-
H
A
E
C
E
E
--
R
D
A
F
F
D
F
A
M
H
S
Q
R
L
Y
K
G
L
G
E
E
L
Y
A
L
S
G
V
D
I
R
Q
H
N
G
G
M
F
K
L
A
F
S
E
E
D
V
L
Q
L
R
Q
M
D
----
D
------
L
-----------
D
S
V
S
W
Y
S
K
E
E
-
V
L
E
K
E
------
P
Y
A
S
G
-
D
-
I
F
G
A
S
F
I
Q
D
D
V
H
V
E
P
Y
F
V
C
K
A
Y
V
K
A
A
K
M
L
G
A
E
I
F
E
H
T
P
V
L
H
V
E
R
D
G
-
E
A
L
F
-
I
K
T
P
S
G
D
V
W
A
N
H
V
V
V
A
S
G
V
W
S
G
M
F
F
K
Q
L
G
L
--
N
N
A
F
L
P
V
K
G
E
C
L
S
V
W
N
D
D
I
-
P
-
L
T
-
K
-
T
--
L
-
Y
---
H
---
D
---------
H
C
Y
I
V
P
R
K
S
G
R
L
V
---------------
V
G
A
T
M
K
P
G
---------------
D
W
S
---
E
--
T
P
D
L
G
G
L
E
S
V
M
K
K
A
K
T
M
L
P
P
I
Q
N
M
K
V
D
R
F
W
A
G
L
R
P
G
T
K
D
G
K
P
Y
I
G
R
H
P
E
D
S
R
I
L
F
A
A
G
H
F
R
N
G
I
L
L
A
P
A
T
G
A
L
I
S
D
L
I
M
N
K
E
V
N
Q
-
D
W
L
H
A
F
R
I
D
R
K
-----
25
PsiBlast_CBE
81.47
99%
-110
- C2 -
1NG3
3
GLOX_BACSU
B:
[22-385]
M
K
R
H
Y
E
A
V
V
I
G
G
G
I
I
G
S
A
I
A
Y
Y
L
A
K
E
N
-
K
-
N
T
A
L
F
E
S
G
T
M
G
G
R
T
T
S
A
A
A
G
M
L
G
A
-
H
A
E
C
E
E
--
R
D
A
F
F
D
F
A
M
H
S
Q
R
L
Y
K
G
L
G
E
E
L
Y
A
L
S
G
V
D
I
R
Q
H
N
G
G
M
F
K
L
A
F
S
E
E
D
V
L
Q
L
R
Q
M
D
----
D
------
L
-----------
D
S
V
S
W
Y
S
K
E
E
-
V
L
E
K
E
------
P
Y
A
S
G
-
D
-
I
F
G
A
S
F
I
Q
D
D
V
H
V
E
P
Y
F
V
C
K
A
Y
V
K
A
A
K
M
L
G
A
E
I
F
E
H
T
P
V
L
H
V
E
R
D
G
-
E
A
L
F
-
I
K
T
P
S
G
D
V
W
A
N
H
V
V
V
A
S
G
V
W
S
G
M
F
F
K
Q
L
G
L
--
N
N
A
F
L
P
V
K
G
E
C
L
S
V
W
N
D
D
I
-
P
-
L
T
-
K
-
T
--
L
-
Y
---
H
---
D
---------
H
C
Y
I
V
P
R
K
S
G
R
L
V
---------------
V
G
A
T
M
K
P
G
---------------
D
W
S
---
E
--
T
P
D
L
G
G
L
E
S
V
M
K
K
A
K
T
M
L
P
P
I
Q
N
M
K
V
D
R
F
W
A
G
L
R
P
G
T
K
D
G
K
P
Y
I
G
R
H
P
E
D
S
R
I
L
F
A
A
G
H
F
R
N
G
I
L
L
A
P
A
T
G
A
L
I
S
D
L
I
M
N
K
E
V
N
Q
-
D
W
L
H
A
F
R
I
D
R
K
-----
26
PsiBlast_CBE
81.27
99%
-111
- C2 -
3IF9
2
GLOX_BACSU
D:
[14-377]
M
K
R
H
Y
E
A
V
V
I
G
G
G
I
I
G
S
A
I
A
Y
Y
L
A
K
E
N
-
K
-
N
T
A
L
F
E
S
G
T
M
G
G
R
T
T
S
A
A
A
G
M
L
S
A
-
H
---
E
E
--
R
D
A
F
F
D
F
A
M
H
S
Q
R
L
Y
K
G
L
G
E
E
L
Y
A
L
S
G
V
D
I
R
Q
H
N
G
G
M
F
K
L
A
F
S
E
E
D
V
L
Q
L
R
Q
M
D
----
D
------
L
-----------
D
S
V
S
W
Y
S
K
E
E
-
V
L
E
K
E
------
P
Y
A
S
G
-
D
-
I
F
G
A
S
F
I
Q
D
D
V
H
V
E
P
Y
F
V
C
K
A
Y
V
K
A
A
K
M
L
G
A
E
I
F
E
H
T
P
V
L
H
V
E
R
D
G
-
E
A
L
F
-
I
K
T
P
S
G
D
V
W
A
N
H
V
V
V
A
S
G
V
W
S
G
M
F
F
K
Q
L
G
L
--
N
N
A
F
L
P
V
K
G
E
C
L
S
V
W
N
D
D
I
-
P
-
L
T
-
K
-
T
--
L
-
Y
---
H
---
D
---------
A
C
Y
I
V
P
R
K
S
G
R
L
V
---------------
V
G
A
T
M
K
P
G
---------------
D
W
S
---
E
--
T
P
D
L
G
G
L
E
S
V
M
K
K
A
K
T
M
L
P
A
I
Q
N
M
K
V
D
R
F
W
A
G
L
R
P
G
T
K
D
G
K
P
Y
I
G
R
H
P
E
D
S
R
I
L
F
A
A
G
H
F
R
N
G
I
L
L
A
P
A
T
G
A
L
I
S
D
L
I
M
N
K
E
V
N
Q
-
D
W
L
H
A
F
R
I
D
R
K
-----
28
PsiBlast_CBE
80.37
99%
-112
- C2 -
3IF9
2
GLOX_BACSU
B:
[14-377]
M
K
R
H
Y
E
A
V
V
I
G
G
G
I
I
G
S
A
I
A
Y
Y
L
A
K
E
N
-
K
-
N
T
A
L
F
E
S
G
T
M
G
G
R
T
T
S
A
A
A
G
M
L
S
A
-
H
R
E
-
E
E
--
R
D
A
F
F
D
F
A
M
H
S
Q
R
L
Y
K
G
L
G
E
E
L
Y
A
L
S
G
V
D
I
R
Q
H
N
G
G
M
F
K
L
A
F
S
E
E
D
V
L
Q
L
R
Q
M
D
----
D
------
L
-----------
D
S
V
S
W
Y
S
K
E
E
-
V
L
E
K
E
------
P
Y
A
S
G
-
D
-
I
F
G
A
S
F
I
Q
D
D
V
H
V
E
P
Y
F
V
C
K
A
Y
V
K
A
A
K
M
L
G
A
E
I
F
E
H
T
P
V
L
H
V
E
R
D
G
-
E
A
L
F
-
I
K
T
P
S
G
D
V
W
A
N
H
V
V
V
A
S
G
V
W
S
G
M
F
F
K
Q
L
G
L
--
N
N
A
F
L
P
V
K
G
E
C
L
S
V
W
N
D
D
I
-
P
-
L
T
-
K
-
T
--
L
-
Y
---
H
---
D
---------
A
C
Y
I
V
P
R
K
S
G
R
L
V
---------------
V
G
A
T
M
K
P
G
---------------
D
W
S
---
E
--
T
P
D
L
G
G
L
E
S
V
M
K
K
A
K
T
M
L
P
A
I
Q
N
M
K
V
D
R
F
W
A
G
L
R
P
G
T
K
D
G
K
P
Y
I
G
R
H
P
E
D
S
R
I
L
F
A
A
G
H
F
R
N
G
I
L
L
A
P
A
T
G
A
L
I
S
D
L
I
M
N
K
E
V
N
Q
-
D
W
L
H
A
F
R
I
D
R
K
-----
65
HHSearch
78.90
98%
-109
- C2 -
1RYI
2
GLOX_BACSU
A:
[15-377]
-
K
R
H
Y
E
A
V
V
I
G
G
G
I
I
G
S
A
I
A
Y
Y
L
A
K
E
N
-
K
-
N
T
A
L
F
E
S
G
T
M
G
G
R
T
T
S
A
A
A
G
M
L
G
A
-
H
--
A
E
C
EE
R
D
A
F
F
D
F
A
M
H
S
Q
R
L
Y
K
G
L
G
E
E
L
Y
A
L
S
G
V
D
I
R
Q
H
N
G
G
M
F
K
L
A
F
S
E
E
D
V
L
Q
L
R
Q
M
D
----
D
L-----
D
-----------
S
V
-
S
W
Y
S
K
E
E
-
V
L
E
K
E
------
P
Y
A
S
G
-
D
-
I
F
G
A
S
F
I
Q
D
D
V
H
V
E
P
Y
F
V
C
K
A
Y
V
K
A
A
K
M
L
G
A
E
I
F
E
H
T
P
V
L
H
V
E
R
D
G
-
E
A
L
F
-
I
K
T
P
S
G
D
V
W
A
N
H
V
V
V
A
S
G
V
W
S
G
M
F
F
K
Q
L
G
L
--
N
N
A
F
L
P
V
K
G
E
C
L
S
V
W
N
D
D
I
-
P
-
L
T
-
K
-
T
--
L
-
Y
---
H
---
D
---------
H
C
Y
I
V
P
R
K
S
G
R
L
V
---------------
V
G
A
T
M
K
P
G
---------------
D
W
S
---
E
--
T
P
D
L
G
G
L
E
S
V
M
K
K
A
K
T
M
L
P
A
I
Q
N
M
K
V
D
R
F
W
A
G
L
R
P
G
T
K
D
G
K
P
Y
I
G
R
H
P
E
D
S
R
I
L
F
A
A
G
H
F
R
N
G
I
L
L
A
P
A
T
G
A
L
I
S
D
L
I
M
N
K
E
-
V
N
Q
D
W
L
H
A
F
R
I
D
R
K
-----
66
HHSearch
55.87
38%
-117
- C2 -
4YSH
2
?
A:
[2-371]
-
T
H
R
Y
D
V
A
I
V
G
G
G
V
I
G
A
A
I
G
F
E
L
A
K
R
R
-
H
-
R
V
A
I
F
E
K
G
T
M
G
S
G
A
S
S
A
A
A
G
M
L
G
A
-
Q
S
E
F
S
T
--
S
S
P
L
V
P
L
A
L
Q
S
R
A
L
M
P
A
L
A
E
E
L
R
E
R
T
G
I
D
I
G
L
V
E
K
G
L
I
K
L
A
T
T
E
E
E
A
D
D
L
Y
R
H
Y
T
F
W
R
G
I
G----
E
-----------
P
V
-
Q
W
L
T
K
G
E
-
A
L
E
M
E
------
P
R
L
A
E
-
A
-
L
A
G
A
M
Y
I
P
G
D
G
Q
V
S
A
P
D
L
A
A
A
L
A
Y
A
A
A
S
A
G
A
C
L
Y
E
Y
T
E
V
F
D
I
R
S
D
S
-
S
G
H
V
-
L
D
T
T
G
G
T
F
A
A
E
A
V
V
I
A
S
G
A
W
A
A
R
L
G
A
R
V
G
L
--
S
L
S
V
Y
P
V
K
G
E
C
V
M
V
R
A
P
V
P
-
L
--
L
-
Q
T
T
--
V
-
F
---
A
K--
N
---------
G
C
Y
I
V
P
K
S
G
N
R
L
L
---------------
I
G
A
T
S
T
P
G
---------------
T
F
D
---
R
--
R
V
S
A
G
G
V
M
N
L
L
H
R
A
A
H
L
V
P
D
I
E
Q
A
E
W
V
A
S
W
S
G
I
R
P
Q
T
E
D
G
L
P
Y
L
G
E
H
P
E
R
R
G
L
F
V
A
A
G
H
Y
R
N
G
I
L
L
S
P
L
T
G
L
L
V
A
D
L
V
E
R
K
E
-
T
A
-
F
D
L
A
P
F
S
L
T
R
H
I
G
---
67
HHSearch
51.59
25%
-106
* C2 *
1Y56
4
?
B:
[2-372]
L
P
E
K
S
E
I
V
V
I
G
G
G
I
V
G
V
T
I
A
H
E
L
A
K
R
G
-
E
-
E
V
T
V
I
E
K
R
F
I
G
S
G
S
T
F
R
C
G
T
G
I
R
Q
-
Q
--
F
N
---
D
E
A
N
V
R
V
M
K
R
S
V
E
L
W
K
K
Y
S
E
E
Y
----
G
--
F
S
F
K
Q
T
G
Y
L
F
L
L
Y
D
D
E
E
V
K
T
F
K
R
N
I
----
E
I
Q
N
K
F
G
V
-----------
P
T
-
K
L
I
T
P
E
E
-
A
K
E
I
V
------
P
L
L
D
I
S
E
-
V
I
A
A
S
W
N
P
T
D
G
K
A
D
P
F
E
A
T
T
A
F
A
V
K
A
K
E
Y
G
A
K
L
L
E
Y
T
E
V
K
G
F
L
I
E
N
N
E
I
K
G
-
V
K
T
N
K
G
I
I
K
T
G
I
V
V
N
A
T
N
A
W
A
N
L
I
N
A
M
A
G
I
KT
K
I
P
I
E
P
Y
K
H
Q
A
V
I
T
Q
P
I
K
R
-
G
-
T
I
-
N
-
P
--
M
V
I
SFK
Y
---
G
---------
H
A
Y
L
T
Q
T
F
H
G
G
I
I
---------------
G
G
I
G
Y
E
I
G
P--------------
T
Y
D
---
L
--
T
P
T
Y
E
F
L
R
E
V
S
Y
Y
F
T
K
I
I
P
A
L
K
N
L
L
I
L
R
T
W
A
G
Y
Y
A
K
T
P
D
S
N
P
A
I
G
R
I
E
E
L
N
D
Y
Y
I
A
A
G
F
S
G
H
G
F
M
M
A
P
A
V
G
E
M
V
A
E
L
I
T
K
G
K
-
T
K
-
L
P
V
E
W
Y
D
P
Y
R
F
E
R
G
--
29
PsiBlast_CBE
51.14
37%
-108
- C2 -
4YSH
7
?
B:
[21-368]
--------------------
F
E
L
A
K
R
R
-
H
-
R
V
A
I
F
E
K
G
T
M
G
S
G
A
S
S
A
A
A
G
M
L
G
A
-
Q
S
E
F
S
T
--
S
S
P
L
V
P
L
A
L
Q
S
R
A
L
M
P
A
L
A
E
E
L
R
E
R
T
G
I
D
I
G
L
V
E
K
G
L
I
K
L
A
T
T
E
E
E
A
------
D
----
D
------
L
YRHYTFWRGIG
E
P
V
Q
W
L
T
K
G
E
-
A
L
E
M
E
------
P
R
L
A
E
-
A
-
L
A
G
A
M
Y
I
P
G
D
G
Q
V
S
A
P
D
L
A
A
A
L
A
Y
A
A
A
S
A
G
A
C
L
Y
E
Y
T
E
V
F
D
I
R
S
D
S
-
S
G
H
V
-
L
D
T
T
G
G
T
F
A
A
E
A
V
V
I
A
S
G
A
W
A
A
R
L
G
A
R
V
G
L
--
S
L
S
V
Y
P
V
K
G
E
C
V
M
V
-
R
A
P
V
-
P
-
L
L
-
Q
-
T
TV
F
-
A
---
K
---
N
---------
G
C
Y
I
V
P
K
S
G
N
R
L
L
---------------
I
G
A
T
S
T
P
G
---------------
T
F
D
---
R
--
R
V
S
A
G
G
V
M
N
L
L
H
R
A
A
H
L
V
P
D
I
E
Q
A
E
W
V
A
S
W
S
G
I
R
P
Q
T
E
D
G
L
P
Y
L
G
E
H
P
E
R
R
G
L
F
V
A
A
G
H
Y
R
N
G
I
L
L
S
P
L
T
G
L
L
V
A
D
L
V
E
R
K
E
T
A
F
-
D
-
L
A
P
F
S
L
T
R
------
73
HHSearch
50.14
25%
-111
- C2 -
4PAB
4
M2GD_RAT
A:
[42-430]
-
K
D
R
A
E
T
V
I
I
G
G
G
C
V
G
V
S
L
A
Y
H
L
A
K
A
G
-
M
R
D
V
V
L
L
E
K
S
E
L
T
A
G
S
T
W
H
A
A
G
L
T
T
Y
-
F
--
H
P
---
G
I
N
L
K
K
I
H
Y
D
S
I
K
L
Y
E
R
L
E
E
E
T
----
G
Q
V
V
G
F
H
Q
P
G
S
I
R
L
A
T
T
P
E
R
V
D
E
F
K
Y
Q
M
----
T
R
T
N
WHA
T
-----------
E
Q
-
Y
I
I
E
P
E
K
-
I
H
E
L
F
------
P
L
L
N
M
D
K
-
I
L
A
G
L
Y
N
P
G
D
G
H
I
D
P
Y
S
L
T
M
A
L
A
T
G
A
R
K
Y
G
V
L
L
K
Y
P
A
P
V
T
S
L
K
P
R
P
D
G
T
W
D
-
V
E
T
P
Q
G
S
V
R
A
N
R
I
V
N
A
A
G
F
W
A
R
E
V
G
K
M
I
G
L
--
D
H
P
L
I
P
V
Q
H
Q
Y
V
V
T
S
T
I
P
E
V
K
A
L
K
R
E
L
P
--
V
-
L
---
R
DLE
G
---------
S
Y
Y
L
R
Q
E
R
D
G
-
L
L
---------------
F
G
P
Y
E
S
Q
E
KMKLQ
A
S
W
V
A
HGVPP
G
F
G
KEL
F
--
E
S
D
L
D
R
I
T
E
H
V
E
A
A
M
E
M
V
P
V
L
K
K
A
D
I
I
N
I
V
N
G
P
I
T
Y
S
P
D
I
L
P
M
V
G
P
H
Q
G
V
R
N
Y
W
V
A
I
G
F
-
G
Y
G
I
I
H
A
G
G
V
G
K
Y
L
S
D
W
I
L
H
G
E
-
P
P
-
F
D
L
I
E
L
D
P
N
R
Y
G
K
W
--
7
PsiBlast_PDB
49.96
25%
-108
- C2 -
4PAA
1
M2GD_RAT
A:
[21-393]
-
K
D
R
A
E
T
V
I
I
G
G
G
C
V
G
V
S
L
A
Y
H
L
A
K
A
G
M
R
-
D
V
V
L
L
E
K
S
E
L
T
A
G
S
T
W
H
A
A
G
L
T
T
Y
F
H
P
G
I
N
L
--
K
K
I
H
Y
D
----
S
I
K
L
Y
E
R
L
E
E
E
T
G
Q
V
V
G
F
----
H
Q
P
G
S
I
R
L
A
T
T
P
E
R
V
D
E
F
K
Y
------
Q
------
M
-----------
T
R
T
N
W
H
A
T
E
Q
Y
I
I
E
P
E
K
I
H
E
L
F
P
L
L
N
M
-
D
K
I
L
A
G
L
Y
N
P
G
D
G
H
I
D
P
Y
S
L
T
M
A
L
A
T
G
A
R
K
Y
G
A
L
L
K
Y
P
A
P
V
T
S
L
K
P
R
P
-
D
G
T
W
D
V
E
T
P
Q
G
S
V
R
A
N
R
I
V
N
A
A
G
F
W
A
R
E
V
G
K
M
I
G
L
--
D
H
P
L
I
P
V
Q
H
Q
Y
--
V
I
T
S
T
I
-
P
-
E
V
-
K
-
A
--
L
-
K
---
R
---
E
L
P
VLRDLEG
S
Y
Y
L
R
Q
E
R
D
G
L
L
F
G
P
YESQEK
M
K
L
Q
A
S
W
V
A
H
G
V
P
P
G
---------------
F
G
K
---
E
LF
E
S
D
L
D
R
I
T
E
H
V
E
A
A
M
E
M
V
P
V
L
K
K
A
D
I
I
N
I
V
N
G
P
I
T
Y
S
P
D
I
L
P
M
V
G
P
H
-
Q
G
V
R
N
Y
W
V
A
I
G
F
G
Y
G
I
I
H
A
G
G
V
G
T
Y
L
S
D
W
I
L
H
G
E
--------------------
5
PsiBlast_PDB
49.90
37%
-106
- C2 -
4YSH
2
?
A:
[21-368]
--------------------
F
E
L
A
K
R
R
-
H
-
R
V
A
I
F
E
K
G
T
M
G
S
G
A
S
S
A
A
A
G
M
L
G
A
-
Q
S
E
F
S
T
--
S
S
P
L
V
P
L
A
L
Q
S
R
A
L
M
P
A
L
A
E
E
L
R
E
R
T
G
I
D
I
G
L
V
E
K
G
L
I
K
L
A
T
T
E
E
E
A
------
D
----
D
------
L
Y
R
H
Y
T
F
W
R
G
I
G
E
P
V
Q
W
L
T
K
G
E
-
A
L
E
M
E
------
P
R
L
A
E
-
A
-
L
A
G
A
M
Y
I
P
G
D
G
Q
V
S
A
P
D
L
A
A
A
L
A
Y
A
A
A
S
A
G
A
C
L
Y
E
Y
T
E
V
F
D
I
R
S
D
S
-
S
G
H
V
-
L
D
T
T
G
G
T
F
A
A
E
A
V
V
I
A
S
G
A
W
A
A
R
L
G
A
R
V
G
L
--
S
L
S
V
Y
P
V
K
G
E
C
V
M
V
-
R
A
P
V
-
P
-
L
L
-
Q
-
T
T
V
F
-
A
---
K
---
N
---------
G
C
Y
I
V
P
K
S
G
N
R
L
L
---------------
I
G
A
T
S
T
P
G
---------------
T
F
D
---
R
--
R
V
S
A
G
G
V
M
N
L
L
H
R
A
A
H
L
V
P
D
I
E
Q
A
E
W
V
A
S
W
S
G
I
R
P
Q
T
E
D
G
L
P
Y
L
G
E
H
P
E
R
R
G
L
F
V
A
A
G
H
Y
R
N
G
I
L
L
S
P
L
T
G
L
L
V
A
D
L
V
E
R
K
E
T
A
F
-
D
-
L
A
P
F
S
L
T
R
------
8
PsiBlast_PDB
49.41
25%
-107
- C2 -
4PAB
3
M2GD_RAT
A:
[42-414]
-
K
D
R
A
E
T
V
I
I
G
G
G
C
V
G
V
S
L
A
Y
H
L
A
K
A
G
M
R
-
D
V
V
L
L
E
K
S
E
L
T
A
G
S
T
W
H
A
A
G
L
T
T
Y
F
H
P
G
I
N
L
--
K
K
I
H
Y
D
----
S
I
K
L
Y
E
R
L
E
E
E
T
G
Q
V
V
G
F
----
H
Q
P
G
S
I
R
L
A
T
T
P
E
R
V
D
E
F
K
Y
------
Q
------
M
-----------
T
R
T
N
W
H
A
T
E
Q
Y
I
I
E
P
E
K
I
H
E
L
F
P
L
L
N
M
-
D
K
I
L
A
G
L
Y
N
P
G
D
G
H
I
D
P
Y
S
L
T
M
A
L
A
T
G
A
R
K
Y
G
V
L
L
K
Y
P
A
P
V
T
S
L
K
P
R
P
-
D
G
T
W
D
V
E
T
P
Q
G
S
V
R
A
N
R
I
V
N
A
A
G
F
W
A
R
E
V
G
K
M
I
G
L
--
D
H
P
L
I
P
V
Q
H
Q
Y
--
V
V
T
S
T
I
-
P
-
E
V
-
K
-
A
--
L
-
K
---
R
---
E
L
P
VLRDLEG
S
Y
Y
L
R
Q
E
R
D
G
L
L
F
G
P
YESQEKMKLQ
A
S
W
V
A
H
G
V
P
P
G
---------------
F
G
K
---
E
LF
E
S
D
L
D
R
I
T
E
H
V
E
A
A
M
E
M
V
P
V
L
K
K
A
D
I
I
N
I
V
N
G
P
I
T
Y
S
P
D
I
L
P
M
V
G
P
H
-
Q
G
V
R
N
Y
W
V
A
I
G
F
G
Y
G
I
I
H
A
G
G
V
G
K
Y
L
S
D
W
I
L
H
G
E
--------------------