@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu23820: (2016-07-07 )
MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAHYISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQLAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDVIEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSASDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQADMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQYERGW
Atome Classification :
(32 SA)
.........10........20........30........40........50........60........70........80........90........100......--.110--------.----..-.----------.------------....-120.....-.----------------.130.......140.......150.......160.......170.......180.......190.......200.....--.--.210......---..220...-...-.230.......240.......250...-...-..260.......270.......280.......290.......300.......310..-.....320-.....-----..330......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MARKLFTP
I
T
I
KDMTLKN
R
I
V
MSPMCMYSSHEKDGKL
T
P
F
H
M
A
H
Y
I
S
R
A
IGQV
G
L
I
I
V
E
ASAVNPQGRITDQDLGIW
S
D
E
H
I
E
G
F
A
K
L
T
E
Q
V
K
EQGSKI
G
I
Q
L
AHAGR--KA----------E----LE-G----------D------------IFAP-S
A
I
AFDEQ-S----------------ATP
V
E
M
S
A
E
K
V
K
E
T
V
Q
E
F
K
Q
A
A
A
R
A
K
EAGF
D
V
I
E
I
HAA
H
G
Y
L
I
H
E
F
L
S
P
L
SNHRTDEYGG
S
P
E
N
R
Y
R
F
L
R
E
I
I
D
E
V
K
Q
V--W--DG
P
-
L
F
V
R
V
S---ASDYTDKG-L
D
I
-
A
D
H
I
G
F
A
K
W
M
K
EQGV
D
L
I
DCSSG-
A
L
V
-
H
A
D
-
I
NVFPGY
Q
V
S
F
A
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K
I
R
E
Q
ADMATG
A
V
G
MITD
G
S
M
A
E
E
I
L
QNGRA
D
L
I
F
I
G
R
E
L
LRDP-
F
F
A
R
T
A
A
K
-
Q
LNTE-----IPAPVQYERGW
112
HHSearch
97.98
100%
-94
- C2 -
1Z41
5
NAMA_BACSU
A:
[2-338]
-
A
R
K
L
F
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L
K
N
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L
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A
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Q
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----------------
A
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V
Q
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K
Q
A
A
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Y
L
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G
G
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I
D
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Q
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--
W
--
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P
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L
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---
A
S
D
Y
T
D
K
G
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L
D
I
-
A
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I
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F
A
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W
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K
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A
L
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A
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-
I
N
V
F
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Y
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L
Q
N
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F
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Q
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N
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-----
I
P
A
P
V
Q
Y
E
R
G
W
2
PsiBlast_PDB
97.65
97%
-93
- C2 -
1Z42
5
NAMA_BACSU
A:
[2-338]
-
A
R
K
L
F
T
P
I
T
I
K
D
M
T
L
K
N
R
I
V
M
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M
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Y
S
S
H
E
K
D
G
K
L
T
P
F
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A
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A
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Q
V
G
L
I
I
V
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A
S
A
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P
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D
Q
D
L
G
I
W
S
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Q
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K
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Q
G
S
K
I
G
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Q
L
A
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K
A
----------
E
----
L
E
-
G
----------
D
------------
I
F
A
P
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S
A
I
A
F
D
E
Q
-
S
----------------
A
T
P
V
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A
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K
V
K
E
T
V
Q
E
F
K
Q
A
A
A
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I
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A
A
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Y
L
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L
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P
L
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N
H
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D
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Y
G
G
S
P
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R
Y
R
F
L
R
E
I
I
D
E
V
K
Q
V
--
W
--
D
G
P
-
L
F
V
R
V
S
---
A
S
D
Y
T
D
K
G
-
L
D
I
-
A
D
H
I
G
F
A
K
W
M
K
E
Q
G
V
D
L
I
D
C
S
S
G
-
A
L
V
-
H
A
D
-
I
N
V
F
P
G
Y
Q
V
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F
A
E
K
I
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Q
A
D
M
A
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A
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S
M
A
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I
L
Q
N
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R
A
D
L
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L
L
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P
-
F
F
A
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A
A
K
-
Q
L
N
T
E
-----
I
P
A
P
V
Q
Y
E
R
G
W
3
PsiBlast_PDB
97.52
97%
-95
- C2 -
1Z44
7
NAMA_BACSU
A:
[2-338]
-
A
R
K
L
F
T
P
I
T
I
K
D
M
T
L
K
N
R
I
V
M
S
P
M
C
M
Y
S
S
H
E
K
D
G
K
L
T
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F
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A
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A
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Q
V
G
L
I
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A
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A
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N
P
Q
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D
Q
D
L
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W
S
D
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A
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Q
V
K
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K
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A
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A
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K
A
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----
L
E
-
G
----------
D
------------
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F
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A
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A
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D
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Q
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S
----------------
A
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V
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Q
A
A
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I
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A
A
H
G
Y
L
I
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L
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P
L
S
N
H
R
T
D
E
Y
G
G
S
P
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R
Y
R
F
L
R
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I
I
D
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K
Q
V
--
W
--
D
G
P
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L
F
V
R
V
S
---
A
S
D
Y
T
D
K
G
-
L
D
I
-
A
D
H
I
G
F
A
K
W
M
K
E
Q
G
V
D
L
I
D
C
S
S
G
-
A
L
V
-
H
A
D
-
I
N
V
F
P
G
Y
Q
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A
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K
I
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A
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L
Q
N
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-----
I
P
A
P
V
Q
Y
E
R
G
W
1
PsiBlast_PDB
97.33
97%
-94
- C2 -
1Z41
5
NAMA_BACSU
A:
[2-338]
-
A
R
K
L
F
T
P
I
T
I
K
D
M
T
L
K
N
R
I
V
M
S
P
M
C
M
Y
S
S
H
E
K
D
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K
L
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A
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Y
I
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A
I
G
Q
V
G
L
I
I
V
E
A
S
A
V
N
P
Q
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D
Q
D
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A
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A
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--
K
A
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----
L
E
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------------
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F
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A
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A
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Q
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S
----------------
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A
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K
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K
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V
Q
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F
K
Q
A
A
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A
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F
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V
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I
H
A
A
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Y
L
I
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F
L
S
P
L
S
N
H
R
T
D
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Y
G
G
S
P
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Y
R
F
L
R
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I
I
D
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Q
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W
--
D
G
P
-
L
F
V
R
V
S
---
A
S
D
Y
T
D
K
G
-
L
D
I
-
A
D
H
I
G
F
A
K
W
M
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E
Q
G
V
D
L
I
D
C
S
S
G
-
A
L
V
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A
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I
N
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Y
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A
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L
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N
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A
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Y
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W
4
PsiBlast_PDB
97.24
97%
-92
- C2 -
1Z48
2
NAMA_BACSU
A:
[2-338]
-
A
R
K
L
F
T
P
I
T
I
K
D
M
T
L
K
N
R
I
V
M
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M
C
M
Y
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E
K
D
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F
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Y
I
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A
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G
Q
V
G
L
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E
A
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N
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---
A
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Y
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L
D
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A
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-----
I
P
A
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G
W
111
HHSearch
91.96
67%
-95
- C2 -
3GR7
3
NAMA_GEOKA
A:
[1-338]
M
N
T
M
L
F
S
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Y
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K
N
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G
R
E
L
L
R
N
P
-
Y
W
P
Y
A
A
A
R
-
E
L
G
A
K
-----
I
S
A
P
V
Q
Y
E
R
G
W
5
PsiBlast_PDB
91.75
66%
-95
- C2 -
3GR7
3
NAMA_GEOKA
A:
[1-338]
M
N
T
M
L
F
S
P
Y
T
I
R
G
L
T
L
K
N
R
I
V
M
S
P
M
C
M
Y
S
C
D
T
K
D
G
A
V
R
T
W
H
K
I
H
Y
P
A
R
A
V
G
Q
V
G
L
I
I
V
E
A
T
G
V
T
P
Q
G
R
I
S
E
R
D
L
G
I
W
S
D
D
H
I
A
G
L
R
E
L
V
G
L
V
K
E
H
G
A
A
I
G
I
Q
L
A
H
A
G
R
--
K
S
----------
Q
----
V
P
-
G
----------
E
------------
I
I
A
P
-
S
A
V
P
F
D
D
S
-
S
----------------
P
T
P
K
E
M
T
K
A
D
I
E
E
T
V
Q
A
F
Q
N
G
A
R
R
A
K
E
A
G
F
D
V
I
E
I
H
A
A
H
G
Y
L
I
N
E
F
L
S
P
L
S
N
R
R
Q
D
E
Y
G
G
S
P
E
N
R
Y
R
F
L
G
E
V
I
D
A
V
R
E
V
--
W
--
D
G
P
-
L
F
V
R
I
S
---
A
S
D
Y
H
P
D
G
-
L
T
A
-
K
D
Y
V
P
Y
A
K
R
M
K
E
Q
G
V
D
L
V
D
V
S
S
G
-
A
I
V
-
P
A
R
-
M
N
V
Y
P
G
Y
Q
V
P
F
A
E
L
I
R
R
E
A
D
I
P
T
G
A
V
G
L
I
T
S
G
W
Q
A
E
E
I
L
Q
N
G
R
A
D
L
V
F
L
G
R
E
L
L
R
N
P
-
Y
W
P
Y
A
A
A
R
-
E
L
G
A
K
-----
I
S
A
P
V
Q
Y
E
R
G
W
22
PsiBlast_CBE
91.21
66%
-95
- C2 -
3GR7
3
NAMA_GEOKA
B:
[1-338]
M
N
T
M
L
F
S
P
Y
T
I
R
G
L
T
L
K
N
R
I
V
M
S
P
M
C
M
Y
S
C
D
T
K
D
G
A
V
R
T
W
H
K
I
H
Y
P
A
R
A
V
G
Q
V
G
L
I
I
V
E
A
T
G
V
T
P
Q
G
R
I
S
E
R
D
L
G
I
W
S
D
D
H
I
A
G
L
R
E
L
V
G
L
V
K
E
H
G
A
A
I
G
I
Q
L
A
H
A
G
R
--
K
S
----------
Q
----
V
P
-
G
----------
E
------------
I
I
A
P
-
S
A
V
P
F
D
D
S
-
S
----------------
P
T
P
K
E
M
T
K
A
D
I
E
E
T
V
Q
A
F
Q
N
G
A
R
R
A
K
E
A
G
F
D
V
I
E
I
H
A
A
H
G
Y
L
I
N
E
F
L
S
P
L
S
N
R
R
Q
D
E
Y
G
G
S
P
E
N
R
Y
R
F
L
G
E
V
I
D
A
V
R
E
V
--
W
--
D
G
P
-
L
F
V
R
I
S
---
A
S
D
Y
H
P
D
G
-
L
T
A
-
K
D
Y
V
P
Y
A
K
R
M
K
E
Q
G
V
D
L
V
D
V
S
S
G
-
A
I
V
-
P
A
R
-
M
N
V
Y
P
G
Y
Q
V
P
F
A
E
L
I
R
R
E
A
D
I
P
T
G
A
V
G
L
I
T
S
G
W
Q
A
E
E
I
L
Q
N
G
R
A
D
L
V
F
L
G
R
E
L
L
R
N
P
-
Y
W
P
Y
A
A
A
R
-
E
L
G
A
K
-----
I
S
A
P
V
Q
Y
E
R
G
W
21
PsiBlast_CBE
91.07
66%
-92
- C2 -
3GR8
3
NAMA_GEOKA
B:
[1-338]
M
N
T
M
L
F
S
P
Y
T
I
R
G
L
T
L
K
N
R
I
V
M
S
P
M
C
M
Y
S
C
D
T
K
D
G
A
V
R
T
W
H
K
I
H
Y
P
A
R
A
V
G
Q
V
G
L
I
I
V
E
A
T
G
V
T
P
Q
G
R
I
S
E
R
D
L
G
I
W
S
D
D
H
I
A
G
L
R
E
L
V
G
L
V
K
E
H
G
A
A
I
G
I
Q
L
A
H
A
G
R
--
K
S
----------
Q
----
V
P
-
G
----------
E
------------
I
I
A
P
-
S
A
V
P
F
D
D
S
-
S
----------------
P
T
P
K
E
M
T
K
A
D
I
E
E
T
V
Q
A
F
Q
N
G
A
R
R
A
K
E
A
G
F
D
V
I
E
I
H
A
A
H
G
Y
L
I
N
E
F
L
S
P
L
S
N
R
R
Q
D
E
Y
G
G
S
P
E
N
R
Y
R
F
L
G
E
V
I
D
A
V
R
E
V
--
W
--
D
G
P
-
L
F
V
R
I
S
---
A
S
D
Y
H
P
D
G
-
L
T
A
-
K
D
Y
V
P
Y
A
K
R
M
K
E
Q
G
V
D
L
V
D
V
S
S
G
-
A
I
V
-
P
A
R
-
M
N
V
Y
P
G
Y
Q
V
P
F
A
E
L
I
R
R
E
A
D
I
P
T
G
A
V
G
L
I
T
S
G
W
Q
A
E
E
I
L
Q
N
G
R
A
D
L
V
F
L
G
R
E
L
L
R
N
P
-
Y
W
P
Y
A
A
A
R
-
E
L
G
A
K
-----
I
S
A
P
V
Q
Y
E
R
G
W
6
PsiBlast_PDB
90.84
66%
-93
- C2 -
3GR8
4
NAMA_GEOKA
A:
[1-338]
M
N
T
M
L
F
S
P
Y
T
I
R
G
L
T
L
K
N
R
I
V
M
S
P
M
C
M
Y
S
C
D
T
K
D
G
A
V
R
T
W
H
K
I
H
Y
P
A
R
A
V
G
Q
V
G
L
I
I
V
E
A
T
G
V
T
P
Q
G
R
I
S
E
R
D
L
G
I
W
S
D
D
H
I
A
G
L
R
E
L
V
G
L
V
K
E
H
G
A
A
I
G
I
Q
L
A
H
A
G
R
--
K
S
----------
Q
----
V
P
-
G
----------
E
------------
I
I
A
P
-
S
A
V
P
F
D
D
S
-
S
----------------
P
T
P
K
E
M
T
K
A
D
I
E
E
T
V
Q
A
F
Q
N
G
A
R
R
A
K
E
A
G
F
D
V
I
E
I
H
A
A
H
G
Y
L
I
N
E
F
L
S
P
L
S
N
R
R
Q
D
E
Y
G
G
S
P
E
N
R
Y
R
F
L
G
E
V
I
D
A
V
R
E
V
--
W
--
D
G
P
-
L
F
V
R
I
S
---
A
S
D
Y
H
P
D
G
-
L
T
A
-
K
D
Y
V
P
Y
A
K
R
M
K
E
Q
G
V
D
L
V
D
V
S
S
G
-
A
I
V
-
P
A
R
-
M
N
V
Y
P
G
Y
Q
V
P
F
A
E
L
I
R
R
E
A
D
I
P
T
G
A
V
G
L
I
T
S
G
W
Q
A
E
E
I
L
Q
N
G
R
A
D
L
V
F
L
G
R
E
L
L
R
N
P
-
Y
W
P
Y
A
A
A
R
-
E
L
G
A
K
-----
I
S
A
P
V
Q
Y
E
R
G
W
115
HHSearch
77.45
50%
-29
- C2 -
3HGJ
4
?
A:
[2-349]
--
A
L
L
F
T
P
L
E
L
G
G
L
R
L
K
N
R
L
A
M
S
P
M
C
Q
Y
S
A
T
-
L
E
G
E
V
T
D
W
H
L
L
H
Y
P
T
R
A
L
G
G
V
G
L
I
L
V
E
A
T
A
V
E
P
L
G
R
I
S
P
Y
D
L
G
I
W
S
E
D
H
L
P
G
L
K
E
L
A
R
R
I
R
E
A
G
A
V
P
G
I
Q
L
A
H
A
G
R
--
K
A
----------
G
----
T
A
-
R
PWEGGKPLGW
R
------------
V
V
G
P
-
S
P
I
P
F
D
E
G
-
Y
----------------
P
V
P
E
P
L
D
E
A
G
M
E
R
I
L
Q
A
F
V
E
G
A
R
R
A
L
R
A
G
F
Q
V
I
E
L
H
M
A
H
G
Y
L
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
A
Y
G
G
S
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
R
E
V
--
V
PR
E
L
P
-
L
F
V
R
V
S
---
A
T
D
W
G
E
G
G
-
W
S
L
-
E
D
T
L
A
F
A
R
R
L
K
E
L
G
V
D
L
L
D
C
S
S
G
-
G
V
V
-
L
R
V
R
I
P
L
A
P
G
F
Q
V
P
F
A
D
A
V
R
K
R
V
G
L
R
T
G
A
V
G
L
I
T
T
P
E
Q
A
E
T
L
L
Q
A
G
S
A
D
L
V
L
L
G
R
V
L
L
R
D
P
-
Y
F
P
L
R
A
A
K
-
A
L
G
V
A
-----
P
E
V
P
P
Q
Y
Q
R
G
F
31
PsiBlast_CBE
77.26
48%
-30
- C2 -
3HGJ
2
?
B:
[4-349]
----
L
F
T
P
L
E
L
G
G
L
R
L
K
N
R
L
A
M
S
P
M
C
Q
Y
S
A
-
T
L
E
G
E
V
T
D
W
H
L
L
H
Y
P
T
R
A
L
G
G
V
G
L
I
L
V
E
A
T
A
V
E
P
L
G
R
I
S
P
Y
D
L
G
I
W
S
E
D
H
L
P
G
L
K
E
L
A
R
R
I
R
E
A
G
A
V
P
G
I
Q
L
A
H
A
G
R
--
K
A
GTARPWEGGK
P
----
L
G
-
W
----------
R
------------
V
V
G
P
-
S
P
I
P
F
D
E
G
-
Y
----------------
P
V
P
E
P
L
D
E
A
G
M
E
R
I
L
Q
A
F
V
E
G
A
R
R
A
L
R
A
G
F
Q
V
I
E
L
H
M
A
H
G
Y
L
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
A
Y
G
G
S
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
R
E
V
VP
R
--
E
L
P
-
L
F
V
R
V
S
---
A
T
D
W
G
E
G
G
-
W
S
L
-
E
D
T
L
A
F
A
R
R
L
K
E
L
G
V
D
L
L
D
C
S
S
G
-
G
V
V
L
R
V
R
-
I
P
L
A
P
G
F
Q
V
P
F
A
D
A
V
R
K
R
V
G
L
R
T
G
A
V
G
L
I
T
T
P
E
Q
A
E
T
L
L
Q
A
G
S
A
D
L
V
L
L
G
R
V
L
L
R
D
P
-
Y
F
P
L
R
A
A
K
-
A
L
G
V
A
-----
P
E
V
P
P
Q
Y
Q
R
G
F
29
PsiBlast_CBE
77.00
48%
-29
- C2 -
3HGJ
4
?
D:
[4-349]
----
L
F
T
P
L
E
L
G
G
L
R
L
K
N
R
L
A
M
S
P
M
C
Q
Y
S
A
-
T
L
E
G
E
V
T
D
W
H
L
L
H
Y
P
T
R
A
L
G
G
V
G
L
I
L
V
E
A
T
A
V
E
P
L
G
R
I
S
P
Y
D
L
G
I
W
S
E
D
H
L
P
G
L
K
E
L
A
R
R
I
R
E
A
G
A
V
P
G
I
Q
L
A
H
A
G
R
--
K
A
GTARPWEGGK
P
----
L
G
-
W
----------
R
------------
V
V
G
P
-
S
P
I
P
F
D
E
G
-
Y
----------------
P
V
P
E
P
L
D
E
A
G
M
E
R
I
L
Q
A
F
V
E
G
A
R
R
A
L
R
A
G
F
Q
V
I
E
L
H
M
A
H
G
Y
L
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
A
Y
G
G
S
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
R
E
V
VP
R
--
E
L
P
-
L
F
V
R
V
S
---
A
T
D
W
G
E
G
G
-
W
S
L
-
E
D
T
L
A
F
A
R
R
L
K
E
L
G
V
D
L
L
D
C
S
S
G
-
G
V
V
L
R
V
R
-
I
P
L
A
P
G
F
Q
V
P
F
A
D
A
V
R
K
R
V
G
L
R
T
G
A
V
G
L
I
T
T
P
E
Q
A
E
T
L
L
Q
A
G
S
A
D
L
V
L
L
G
R
V
L
L
R
D
P
-
Y
F
P
L
R
A
A
K
-
A
L
G
V
A
-----
P
E
V
P
P
Q
Y
Q
R
G
F
30
PsiBlast_CBE
76.88
48%
-28
- C2 -
3HGJ
2
?
C:
[4-349]
----
L
F
T
P
L
E
L
G
G
L
R
L
K
N
R
L
A
M
S
P
M
C
Q
Y
S
A
-
T
L
E
G
E
V
T
D
W
H
L
L
H
Y
P
T
R
A
L
G
G
V
G
L
I
L
V
E
A
T
A
V
E
P
L
G
R
I
S
P
Y
D
L
G
I
W
S
E
D
H
L
P
G
L
K
E
L
A
R
R
I
R
E
A
G
A
V
P
G
I
Q
L
A
H
A
G
R
--
K
A
GTARPWEGGK
P
----
L
G
-
W
----------
R
------------
V
V
G
P
-
S
P
I
P
F
D
E
G
-
Y
----------------
P
V
P
E
P
L
D
E
A
G
M
E
R
I
L
Q
A
F
V
E
G
A
R
R
A
L
R
A
G
F
Q
V
I
E
L
H
M
A
H
G
Y
L
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
A
Y
G
G
S
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
R
E
V
VP
R
--
E
L
P
-
L
F
V
R
V
S
---
A
T
D
W
G
E
G
G
-
W
S
L
-
E
D
T
L
A
F
A
R
R
L
K
E
L
G
V
D
L
L
D
C
S
S
G
-
G
V
V
L
R
V
R
-
I
P
L
A
P
G
F
Q
V
P
F
A
D
A
V
R
K
R
V
G
L
R
T
G
A
V
G
L
I
T
T
P
E
Q
A
E
T
L
L
Q
A
G
S
A
D
L
V
L
L
G
R
V
L
L
R
D
P
-
Y
F
P
L
R
A
A
K
-
A
L
G
V
A
-----
P
E
V
P
P
Q
Y
Q
R
G
F
33
PsiBlast_CBE
76.78
48%
-28
- C2 -
3HF3
2
?
C:
[4-349]
----
L
F
T
P
L
E
L
G
G
L
R
L
K
N
R
L
A
M
S
P
M
C
Q
Y
S
A
-
T
L
E
G
E
V
T
D
W
H
L
L
H
Y
P
T
R
A
L
G
G
V
G
L
I
L
V
E
A
T
A
V
E
P
L
G
R
I
S
P
Y
D
L
G
I
W
S
E
D
H
L
P
G
L
K
E
L
A
R
R
I
R
E
A
G
A
V
P
G
I
Q
L
A
H
A
G
R
--
K
A
GTARPWEGGK
P
----
L
G
-
W
----------
R
------------
V
V
G
P
-
S
P
I
P
F
D
E
G
-
Y
----------------
P
V
P
E
P
L
D
E
A
G
M
E
R
I
L
Q
A
F
V
E
G
A
R
R
A
L
R
A
G
F
Q
V
I
E
L
H
M
A
H
G
Y
L
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
A
Y
G
G
S
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
R
E
V
VP
R
--
E
L
P
-
L
F
V
R
V
S
---
A
T
D
W
G
E
G
G
-
W
S
L
-
E
D
T
L
A
F
A
R
R
L
K
E
L
G
V
D
L
L
D
C
S
S
G
-
G
V
V
L
R
V
R
-
I
P
L
A
P
G
F
Q
V
P
F
A
D
A
V
R
K
R
V
G
L
R
T
G
A
V
G
L
I
T
T
P
E
Q
A
E
T
L
L
Q
A
G
S
A
D
L
V
L
L
G
R
V
L
L
R
D
P
-
Y
F
P
L
R
A
A
K
-
A
L
G
V
A
-----
P
E
V
P
P
Q
Y
Q
R
G
F
28
PsiBlast_CBE
76.47
52%
-25
- C2 -
3KRU
3
?
B:
[4-335]
----
L
H
M
P
L
K
I
K
D
I
T
I
K
N
R
I
M
M
S
P
M
C
M
Y
S
A
-
S
T
D
G
M
P
N
D
W
H
I
V
H
Y
A
T
R
A
I
G
G
V
G
L
I
M
Q
E
A
T
A
V
E
S
R
G
R
I
T
D
H
D
L
G
I
W
N
D
E
Q
V
K
E
L
K
K
I
V
D
I
C
K
A
N
G
A
V
M
G
I
Q
L
A
H
A
G
R
--
K
C
----------
N
----
I
S
Y
E
----------
D
------------
V
V
G
P
-
S
P
I
K
A
G
D
R
-
Y
----------------
K
L
P
R
E
L
S
V
E
E
I
K
S
I
V
K
A
F
G
E
A
A
K
R
A
N
L
A
G
Y
D
V
V
E
I
H
A
A
H
G
Y
L
I
H
E
F
L
S
P
L
S
N
K
R
K
D
E
Y
G
N
S
I
E
N
R
A
R
F
L
I
E
V
I
D
E
V
R
K
N
--
W
PE
N
K
P
-
I
F
V
R
V
S
---
A
D
D
Y
M
E
G
G
-
I
N
I
-
D
M
M
V
E
Y
I
N
M
I
K
D
K
-
V
D
L
I
D
V
S
S
G
-
G
L
L
-
N
V
D
-
I
N
L
Y
P
G
Y
Q
V
K
Y
A
E
T
I
K
K
R
C
N
I
K
T
S
A
V
G
L
I
T
T
Q
E
L
A
E
E
I
L
S
N
E
R
A
D
L
V
A
L
G
R
E
L
L
R
N
P
-
Y
W
---
V
L
H
-
T
Y
T
S
K
-----
E
D
W
P
K
Q
Y
E
R
A
F
10
PsiBlast_PDB
76.32
48%
-27
- C2 -
3HGJ
4
?
A:
[4-349]
----
L
F
T
P
L
E
L
G
G
L
R
L
K
N
R
L
A
M
S
P
M
C
Q
Y
S
A
-
T
L
E
G
E
V
T
D
W
H
L
L
H
Y
P
T
R
A
L
G
G
V
G
L
I
L
V
E
A
T
A
V
E
P
L
G
R
I
S
P
Y
D
L
G
I
W
S
E
D
H
L
P
G
L
K
E
L
A
R
R
I
R
E
A
G
A
V
P
G
I
Q
L
A
H
A
G
R
--
K
A
GTARPWEGGK
P
----
L
G
-
W
----------
R
------------
V
V
G
P
-
S
P
I
P
F
D
E
G
-
Y
----------------
P
V
P
E
P
L
D
E
A
G
M
E
R
I
L
Q
A
F
V
E
G
A
R
R
A
L
R
A
G
F
Q
V
I
E
L
H
M
A
H
G
Y
L
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
A
Y
G
G
S
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
R
E
V
VP
R
--
E
L
P
-
L
F
V
R
V
S
---
A
T
D
W
G
E
G
G
-
W
S
L
-
E
D
T
L
A
F
A
R
R
L
K
E
L
G
V
D
L
L
D
C
S
S
G
-
G
V
V
L
R
V
R
-
I
P
L
A
P
G
F
Q
V
P
F
A
D
A
V
R
K
R
V
G
L
R
T
G
A
V
G
L
I
T
T
P
E
Q
A
E
T
L
L
Q
A
G
S
A
D
L
V
L
L
G
R
V
L
L
R
D
P
-
Y
F
P
L
R
A
A
K
-
A
L
G
V
A
-----
P
E
V
P
P
Q
Y
Q
R
G
F
32
PsiBlast_CBE
76.31
48%
-26
- C2 -
3HF3
3
?
D:
[4-349]
----
L
F
T
P
L
E
L
G
G
L
R
L
K
N
R
L
A
M
S
P
M
C
Q
Y
S
A
-
T
L
E
G
E
V
T
D
W
H
L
L
H
Y
P
T
R
A
L
G
G
V
G
L
I
L
V
E
A
T
A
V
E
P
L
G
R
I
S
P
Y
D
L
G
I
W
S
E
D
H
L
P
G
L
K
E
L
A
R
R
I
R
E
A
G
A
V
P
G
I
Q
L
A
H
A
G
R
--
K
A
GTARPWEGGK
P
----
L
G
-
W
----------
R
------------
V
V
G
P
-
S
P
I
P
F
D
E
G
-
Y
----------------
P
V
P
E
P
L
D
E
A
G
M
E
R
I
L
Q
A
F
V
E
G
A
R
R
A
L
R
A
G
F
Q
V
I
E
L
H
M
A
H
G
Y
L
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
A
Y
G
G
S
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
R
E
V
VP
R
--
E
L
P
-
L
F
V
R
V
S
---
A
T
D
W
G
E
G
G
-
W
S
L
-
E
D
T
L
A
F
A
R
R
L
K
E
L
G
V
D
L
L
D
C
S
S
G
-
G
V
V
L
R
V
R
-
I
P
L
A
P
G
F
Q
V
P
F
A
D
A
V
R
K
R
V
G
L
R
T
G
A
V
G
L
I
T
T
P
E
Q
A
E
T
L
L
Q
A
G
S
A
D
L
V
L
L
G
R
V
L
L
R
D
P
-
Y
F
P
L
R
A
A
K
-
A
L
G
V
A
-----
P
E
V
P
P
Q
Y
Q
R
G
F
34
PsiBlast_CBE
76.18
48%
-30
- C2 -
3HF3
2
?
B:
[4-349]
----
L
F
T
P
L
E
L
G
G
L
R
L
K
N
R
L
A
M
S
P
M
C
Q
Y
S
A
-
T
L
E
G
E
V
T
D
W
H
L
L
H
Y
P
T
R
A
L
G
G
V
G
L
I
L
V
E
A
T
A
V
E
P
L
G
R
I
S
P
Y
D
L
G
I
W
S
E
D
H
L
P
G
L
K
E
L
A
R
R
I
R
E
A
G
A
V
P
G
I
Q
L
A
H
A
G
R
--
K
A
GTARPWEGGK
P
----
L
G
-
W
----------
R
------------
V
V
G
P
-
S
P
I
P
F
D
E
G
-
Y
----------------
P
V
P
E
P
L
D
E
A
G
M
E
R
I
L
Q
A
F
V
E
G
A
R
R
A
L
R
A
G
F
Q
V
I
E
L
H
M
A
H
G
Y
L
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
A
Y
G
G
S
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
R
E
V
VP
R
--
E
L
P
-
L
F
V
R
V
S
---
A
T
D
W
G
E
G
G
-
W
S
L
-
E
D
T
L
A
F
A
R
R
L
K
E
L
G
V
D
L
L
D
C
S
S
G
-
G
V
V
L
R
V
R
-
I
P
L
A
P
G
F
Q
V
P
F
A
D
A
V
R
K
R
V
G
L
R
T
G
A
V
G
L
I
T
T
P
E
Q
A
E
T
L
L
Q
A
G
S
A
D
L
V
L
L
G
R
V
L
L
R
D
P
-
Y
F
P
L
R
A
A
K
-
A
L
G
V
A
-----
P
E
V
P
P
Q
Y
Q
R
G
F
25
PsiBlast_CBE
75.54
52%
-28
- C2 -
3KRZ
2
?
B:
[4-335]
----
L
H
M
P
L
K
I
K
D
I
T
I
K
N
R
I
M
M
S
P
M
C
M
Y
S
A
-
S
T
D
G
M
P
N
D
W
H
I
V
H
Y
A
T
R
A
I
G
G
V
G
L
I
M
Q
E
A
T
A
V
E
S
R
G
R
I
T
D
H
D
L
G
I
W
N
D
E
Q
V
K
E
L
K
K
I
V
D
I
C
K
A
N
G
A
V
M
G
I
Q
L
A
H
A
G
R
--
K
C
----------
N
----
I
S
Y
E
----------
D
------------
V
V
G
P
-
S
P
I
K
A
G
D
R
-
Y
----------------
K
L
P
R
E
L
S
V
E
E
I
K
S
I
V
K
A
F
G
E
A
A
K
R
A
N
L
A
G
Y
D
V
V
E
I
H
A
A
H
G
Y
L
I
H
E
F
L
S
P
L
S
N
K
R
K
D
E
Y
G
N
S
I
E
N
R
A
R
F
L
I
E
V
I
D
E
V
R
K
N
--
W
PE
N
K
P
-
I
F
V
R
V
S
---
A
D
D
Y
M
E
G
G
-
I
N
I
-
D
M
M
V
E
Y
I
N
M
I
K
D
K
-
V
D
L
I
D
V
S
S
G
-
G
L
L
-
N
V
D
-
I
N
L
Y
P
G
Y
Q
V
K
Y
A
E
T
I
K
K
R
C
N
I
K
T
S
A
V
G
L
I
T
T
Q
E
L
A
E
E
I
L
S
N
E
R
A
D
L
V
A
L
G
R
E
L
L
R
N
P
-
Y
W
---
V
L
H
-
T
Y
T
S
K
-----
E
D
W
P
K
Q
Y
E
R
A
F
42
PsiBlast_CBE
73.66
39%
-5
- C2 -
4UTL
8
?
A:
[6-359]
----
L
F
E
P
Y
T
L
K
D
V
T
L
R
N
R
I
A
I
P
P
M
C
Q
Y
M
A
--
E
D
G
M
I
N
D
W
H
H
V
H
L
A
G
L
A
R
G
G
A
G
L
L
V
V
E
A
T
A
V
A
P
E
G
R
I
T
P
G
C
A
G
I
W
S
D
A
H
A
Q
A
F
V
P
V
V
Q
A
I
K
A
A
G
S
V
P
G
I
Q
I
A
H
A
G
R
--
K
A
----------
S
ANRP
W
E
-
G
----------
D
DHIAADDTR
G
W
E
T
I
A
P
-
S
A
I
A
F
G
A
H
L
P
----------------
K
V
P
R
E
M
T
L
D
D
I
A
R
V
K
Q
D
F
V
D
A
A
R
R
A
R
D
A
G
F
E
W
I
E
L
H
F
A
H
G
F
L
G
Q
S
F
F
S
E
H
S
N
K
R
T
D
A
Y
G
G
S
F
D
N
R
S
R
F
L
L
E
T
L
A
A
V
R
E
V
--
W
PE
N
L
P
-
L
T
A
R
F
G
---
V
L
E
Y
D
G
R
D
E
Q
T
L
-
E
E
S
I
E
L
A
R
R
F
K
A
G
G
L
D
L
L
S
V
S
V
G
F
T
I
P
-
D
T
N
-
I
P
W
G
P
A
F
M
G
P
I
A
E
R
V
R
R
E
A
K
L
P
V
T
S
A
W
G
F
G
T
P
Q
L
A
E
A
A
L
Q
A
N
Q
L
D
L
V
S
V
G
R
A
H
L
A
D
P
-
H
W
A
Y
F
A
A
K
-
E
L
G
V
E
KASWT
L
P
A
P
Y
A
H
----
47
PsiBlast_CBE
73.32
39%
-4
- C2 -
3L66
12
?
A:
[4-357]
----
L
F
E
P
Y
T
L
K
D
V
T
L
R
N
R
I
A
I
P
P
M
A
Q
Y
M
A
--
E
D
G
M
I
N
D
W
H
H
V
H
L
A
G
L
A
R
G
G
A
G
L
L
V
V
E
A
T
A
V
A
P
E
G
R
I
T
P
G
C
A
G
I
W
S
D
A
H
A
Q
A
F
V
P
V
V
Q
A
I
K
A
A
G
S
V
P
G
I
Q
I
A
H
A
G
R
--
K
A
----------
S
ANRP
W
E
-
G
----------
D
DHIAADDTR
G
W
E
T
I
A
P
-
S
A
I
A
F
G
A
H
L
P
----------------
K
V
P
R
E
M
T
L
D
D
I
A
R
V
K
Q
D
F
V
D
A
A
R
R
A
R
D
A
G
F
E
W
I
E
L
H
F
A
H
G
Y
L
G
Q
S
F
F
S
E
H
S
N
K
R
T
D
A
Y
G
G
S
F
D
N
R
S
R
F
L
L
E
T
L
A
A
V
R
E
V
--
W
PE
N
L
P
-
L
T
A
R
F
G
---
V
L
E
Y
D
G
R
D
E
Q
T
L
-
E
E
S
I
E
L
A
R
R
F
K
A
G
G
L
D
L
L
S
V
S
V
G
F
T
I
P
-
D
T
N
-
I
P
W
G
P
A
F
M
G
P
I
A
E
R
V
R
R
E
A
K
L
P
V
T
S
A
W
G
F
G
T
P
Q
L
A
E
A
A
L
Q
A
N
Q
L
D
L
V
S
V
G
R
A
H
L
A
D
P
-
H
W
A
Y
F
A
A
K
-
E
L
G
V
E
KASWT
L
P
A
P
Y
A
H
----
41
PsiBlast_CBE
73.21
39%
-4
- C2 -
4UTM
4
?
A:
[6-359]
----
L
F
E
P
Y
T
L
K
D
V
T
L
R
N
R
I
A
I
P
P
M
C
Q
Y
M
A
--
E
D
G
M
I
N
D
W
H
H
V
H
L
A
G
L
A
R
G
G
A
G
L
L
V
V
E
A
T
A
V
A
P
E
G
R
I
T
P
G
C
A
G
I
W
S
D
A
H
A
Q
A
F
V
P
V
V
Q
A
I
K
A
A
G
S
V
P
G
I
Q
I
A
H
A
G
R
--
K
A
----------
S
ANRP
W
E
-
G
----------
D
DHIAADDTR
G
W
E
T
I
A
P
-
S
A
I
A
F
G
A
H
L
P
----------------
K
V
P
R
E
M
T
L
D
D
I
A
R
V
K
Q
D
F
V
D
A
A
R
R
A
R
D
A
G
F
E
W
I
E
L
H
F
A
H
G
F
L
G
Q
S
F
F
S
E
H
S
N
K
R
T
D
A
Y
G
G
S
F
D
N
R
S
R
F
L
L
E
T
L
A
A
V
R
E
V
--
W
PE
N
L
P
-
L
T
A
R
F
G
---
V
L
E
Y
D
G
R
D
E
Q
T
L
-
E
E
S
I
E
L
A
R
R
F
K
A
G
G
L
D
L
L
S
V
S
V
G
F
T
I
P
-
D
T
N
-
I
P
W
G
P
A
F
M
G
P
I
A
E
R
V
R
R
E
A
K
L
P
V
T
S
A
W
G
F
G
T
P
Q
L
A
E
A
A
L
Q
A
N
Q
L
D
L
V
S
V
G
R
A
H
L
A
D
P
-
H
W
A
Y
F
A
A
K
-
E
L
G
V
E
KASWT
L
P
A
P
Y
A
H
----
19
PsiBlast_PDB
73.20
39%
-5
- C2 -
2H90
12
?
A:
[3-356]
----
L
F
E
P
Y
T
L
K
D
V
T
L
R
N
R
I
A
I
P
P
M
C
Q
Y
M
A
--
E
D
G
M
I
N
D
W
H
H
V
H
L
A
G
L
A
R
G
G
A
G
L
L
V
V
E
A
T
A
V
A
P
E
G
R
I
T
P
G
C
A
G
I
W
S
D
A
H
A
Q
A
F
V
P
V
V
Q
A
I
K
A
A
G
S
V
P
G
I
Q
I
A
H
A
G
R
--
K
A
----------
S
ANRP
W
E
-
G
----------
D
DHIAADDTR
G
W
E
T
I
A
P
-
S
A
I
A
F
G
A
H
L
P
----------------
K
V
P
R
E
M
T
L
D
D
I
A
R
V
K
Q
D
F
V
D
A
A
R
R
A
R
D
A
G
F
E
W
I
E
L
H
F
A
H
G
Y
L
G
Q
S
F
F
S
E
H
S
N
K
R
T
D
A
Y
G
G
S
F
D
N
R
S
R
F
L
L
E
T
L
A
A
V
R
E
V
--
W
PE
N
L
P
-
L
T
A
R
F
G
---
V
L
E
Y
D
G
R
D
E
Q
T
L
-
E
E
S
I
E
L
A
R
R
F
K
A
G
G
L
D
L
L
S
V
S
V
G
F
T
I
P
-
D
T
N
-
I
P
W
G
P
A
F
M
G
P
I
A
E
R
V
R
R
E
A
K
L
P
V
T
S
A
W
G
F
G
T
P
Q
L
A
E
A
A
L
Q
A
N
Q
L
D
L
V
S
V
G
R
A
H
L
A
D
P
-
H
W
A
Y
F
A
A
K
-
E
L
G
V
E
KASWT
L
P
A
P
Y
A
H
----
45
PsiBlast_CBE
73.13
39%
-6
- C2 -
4UTI
5
?
A:
[6-359]
----
L
F
E
P
Y
T
L
K
D
V
T
L
R
N
R
I
A
I
P
P
M
C
Q
Y
M
A
--
E
D
G
M
I
N
D
W
H
H
V
H
L
A
G
L
A
R
G
G
A
G
L
L
V
V
E
A
T
A
V
A
P
E
G
R
I
T
P
G
C
A
G
I
W
S
D
A
H
A
Q
A
F
V
P
V
V
Q
A
I
K
A
A
G
S
V
P
G
I
Q
I
A
H
A
G
R
--
K
A
----------
S
ANRP
W
E
-
G
----------
D
DHIAADDTR
G
W
E
T
I
A
P
-
S
A
I
A
F
G
A
H
L
P
----------------
K
V
P
R
E
M
T
L
D
D
I
A
R
V
K
Q
D
F
V
D
A
A
R
R
A
R
D
A
G
F
E
W
I
E
L
H
F
A
H
G
F
L
G
Q
S
F
F
S
E
H
S
N
K
R
T
D
A
Y
G
G
S
F
D
N
R
S
R
F
L
L
E
T
L
A
A
V
R
E
V
--
W
PE
N
L
P
-
L
T
A
R
F
G
---
V
L
E
Y
D
G
R
D
E
Q
T
L
-
E
E
S
I
E
L
A
R
R
F
K
A
G
G
L
D
L
L
S
V
S
V
G
F
T
I
P
-
D
T
N
-
I
P
W
G
P
A
F
M
G
P
I
A
E
R
V
R
R
E
A
K
L
P
V
T
S
A
W
G
F
G
T
P
Q
L
A
E
A
A
L
Q
A
N
Q
L
D
L
V
S
V
G
R
A
H
L
A
D
P
-
H
W
A
Y
F
A
A
K
-
E
L
G
V
E
KASWT
L
P
A
P
Y
A
H
----
44
PsiBlast_CBE
73.13
39%
-5
- C2 -
4UTJ
5
?
A:
[6-359]
----
L
F
E
P
Y
T
L
K
D
V
T
L
R
N
R
I
A
I
P
P
M
C
Q
Y
M
A
--
E
D
G
M
I
N
D
W
H
H
V
H
L
A
G
L
A
R
G
G
A
G
L
L
V
V
E
A
T
A
V
A
P
E
G
R
I
T
P
G
C
A
G
I
W
S
D
A
H
A
Q
A
F
V
P
V
V
Q
A
I
K
A
A
G
S
V
P
G
I
Q
I
A
H
A
G
R
--
K
A
----------
S
ANRP
W
E
-
G
----------
D
DHIAADDTR
G
W
E
T
I
A
P
-
S
A
I
A
F
G
A
H
L
P
----------------
K
V
P
R
E
M
T
L
D
D
I
A
R
V
K
Q
D
F
V
D
A
A
R
R
A
R
D
A
G
F
E
W
I
E
L
H
F
A
H
G
F
L
G
Q
S
F
F
S
E
H
S
N
K
R
T
D
A
Y
G
G
S
F
D
N
R
S
R
F
L
L
E
T
L
A
A
V
R
E
V
--
W
PE
N
L
P
-
L
T
A
R
F
G
---
V
L
E
Y
D
G
R
D
E
Q
T
L
-
E
E
S
I
E
L
A
R
R
F
K
A
G
G
L
D
L
L
S
V
S
V
G
F
T
I
P
-
D
T
N
-
I
P
W
G
P
A
F
M
G
P
I
A
E
R
V
R
R
E
A
K
L
P
V
T
S
A
W
G
F
G
T
P
Q
L
A
E
A
A
L
Q
A
N
Q
L
D
L
V
S
V
G
R
A
H
L
A
D
P
-
H
W
A
Y
F
A
A
K
-
E
L
G
V
E
KASWT
L
P
A
P
Y
A
H
----
12
PsiBlast_PDB
73.13
39%
-5
- C2 -
5CPM
2
?
A:
[4-357]
----
L
F
E
P
Y
T
L
K
D
V
T
L
R
N
R
I
A
I
P
P
M
C
Q
Y
M
A
--
E
D
G
L
I
N
D
W
H
Q
V
H
Y
A
S
M
A
R
G
G
A
G
L
L
V
V
E
A
T
A
V
A
P
E
G
R
I
T
P
G
C
A
G
I
W
S
D
A
H
A
Q
A
F
V
P
V
V
Q
A
I
K
A
A
G
S
V
P
G
I
Q
I
A
H
A
G
R
--
K
A
----------
S
ANRP
W
E
-
G
----------
D
DHIGADDAR
G
W
E
T
I
A
P
-
S
A
I
A
F
G
A
H
L
P
----------------
N
V
P
R
A
M
T
L
D
D
I
A
R
V
K
Q
D
F
V
D
A
A
R
R
A
R
D
A
G
F
E
W
I
E
L
H
F
A
H
G
Y
L
G
Q
S
F
F
S
E
H
S
N
K
R
T
D
A
Y
G
G
S
F
D
N
R
S
R
F
L
L
E
T
L
A
A
V
R
E
V
--
W
PE
N
L
P
-
L
T
A
R
F
G
---
V
L
E
Y
D
G
R
D
E
Q
T
L
-
E
E
S
I
E
L
A
R
R
F
K
A
G
G
L
D
L
L
S
V
S
V
G
F
T
I
P
-
E
T
N
-
I
P
W
G
P
A
F
M
G
P
I
A
E
R
V
R
R
E
A
K
L
P
V
T
S
A
W
G
F
G
T
P
Q
L
A
E
A
A
L
Q
A
N
Q
L
D
L
V
S
V
G
R
A
H
L
A
D
P
-
H
W
A
Y
F
A
A
K
-
E
L
G
V
E
KASWT
L
P
A
P
Y
A
H
----
49
PsiBlast_CBE
72.80
39%
-2
- C2 -
3L68
11
?
A:
[4-357]
----
L
F
E
P
Y
T
L
K
D
V
T
L
R
N
R
I
A
I
P
P
M
S
Q
Y
M
A
--
E
D
G
M
I
N
D
W
H
H
V
H
L
A
G
L
A
R
G
G
A
G
L
L
V
V
E
A
T
A
V
A
P
E
G
R
I
T
P
G
C
A
G
I
W
S
D
A
H
A
Q
A
F
V
P
V
V
Q
A
I
K
A
A
G
S
V
P
G
I
Q
I
A
H
A
G
R
--
K
A
----------
S
ANRP
W
E
-
G
----------
D
DHIAADDTR
G
W
E
T
I
A
P
-
S
A
I
A
F
G
A
H
L
P
----------------
K
V
P
R
E
M
T
L
D
D
I
A
R
V
K
Q
D
F
V
D
A
A
R
R
A
R
D
A
G
F
E
W
I
E
L
H
F
A
H
G
Y
L
G
Q
S
F
F
S
E
H
S
N
K
R
T
D
A
Y
G
G
S
F
D
N
R
S
R
F
L
L
E
T
L
A
A
V
R
E
V
--
W
PE
N
L
P
-
L
T
A
R
F
G
---
V
L
E
Y
D
G
R
D
E
Q
T
L
-
E
E
S
I
E
L
A
R
R
F
K
A
G
G
L
D
L
L
S
V
S
V
G
F
T
I
P
-
D
T
N
-
I
P
W
G
P
A
F
M
G
P
I
A
E
R
V
R
R
E
A
K
L
P
V
T
S
A
W
G
F
G
T
P
Q
L
A
E
A
A
L
Q
A
N
Q
L
D
L
V
S
V
G
R
A
H
L
A
D
P
-
H
W
A
Y
F
A
A
K
-
E
L
G
V
E
KASWT
L
P
A
P
Y
A
H
----
16
PsiBlast_PDB
72.69
39%
-5
- C2 -
3L5M
12
?
A:
[4-357]
----
L
F
E
P
Y
T
L
K
D
V
T
L
R
N
R
I
A
I
P
P
M
C
Q
Y
M
A
--
E
D
G
M
I
N
D
W
H
H
V
H
L
A
G
L
A
R
G
G
A
G
L
L
V
V
E
A
T
A
V
A
P
E
G
R
I
T
P
G
C
A
G
I
W
S
D
A
H
A
Q
A
F
V
P
V
V
Q
A
I
K
A
A
G
S
V
P
G
I
Q
I
A
H
A
G
R
--
K
A
----------
S
ANRP
W
E
-
G
----------
D
DHIAADDTR
G
W
E
T
I
A
P
-
S
A
I
A
F
G
A
H
L
P
----------------
K
V
P
R
E
M
T
L
D
D
I
A
R
V
K
Q
D
F
V
D
A
A
R
R
A
R
D
A
G
F
E
W
I
E
L
H
F
A
H
G
Y
L
G
Q
S
F
F
S
E
H
S
N
K
R
T
D
A
Y
G
G
S
F
D
N
R
S
R
F
L
L
E
T
L
A
A
V
R
E
V
--
W
PE
N
L
P
-
L
T
A
R
F
G
---
V
L
E
Y
D
G
R
D
E
Q
T
L
-
E
E
S
I
E
L
A
R
R
F
K
A
G
G
L
D
L
L
S
V
S
V
G
F
T
I
P
-
D
T
N
-
I
P
W
G
P
A
F
M
G
P
I
A
E
R
V
R
R
E
A
K
L
P
V
T
S
A
W
G
F
G
T
P
Q
L
A
E
A
A
L
Q
A
N
Q
L
D
L
V
S
V
G
R
A
H
L
A
D
P
-
H
W
A
Y
F
A
A
K
-
E
L
G
V
E
KASWT
L
P
A
P
Y
A
H
----
37
PsiBlast_CBE
72.65
39%
-1
- C2 -
5CPM
2
?
B:
[4-357]
----
L
F
E
P
Y
T
L
K
D
V
T
L
R
N
R
I
A
I
P
P
M
C
Q
Y
M
A
--
E
D
G
L
I
N
D
W
H
Q
V
H
Y
A
S
M
A
R
G
G
A
G
L
L
V
V
E
A
T
A
V
A
P
E
G
R
I
T
P
G
C
A
G
I
W
S
D
A
H
A
Q
A
F
V
P
V
V
Q
A
I
K
A
A
G
S
V
P
G
I
Q
I
A
H
A
G
R
--
K
A
----------
S
ANRP
W
E
-
G
----------
D
DHIGADDARGWE
T
I
A
P
-
S
A
I
A
F
G
A
H
L
P
----------------
N
V
P
R
A
M
T
L
D
D
I
A
R
V
K
Q
D
F
V
D
A
A
R
R
A
R
D
A
G
F
E
W
I
E
L
H
F
A
H
G
Y
L
G
Q
S
F
F
S
E
H
S
N
K
R
T
D
A
Y
G
G
S
F
D
N
R
S
R
F
L
L
E
T
L
A
A
V
R
E
V
--
W
PE
N
L
P
-
L
T
A
R
F
G
---
V
L
E
Y
D
G
R
D
E
Q
T
L
-
E
E
S
I
E
L
A
R
R
F
K
A
G
G
L
D
L
L
S
V
S
V
G
F
T
I
P
-
E
T
N
-
I
P
W
G
P
A
F
M
G
P
I
A
E
R
V
R
R
E
A
K
L
P
V
T
S
A
W
G
F
G
T
P
Q
L
A
E
A
A
L
Q
A
N
Q
L
D
L
V
S
V
G
R
A
H
L
A
D
P
-
H
W
A
Y
F
A
A
K
-
E
L
G
V
E
KASWT
L
P
A
P
Y
A
H
----
55
PsiBlast_CBE
56.49
32%
10
- C2 -
2ABA
4
?
A:
[3-347]
--
E
K
L
F
T
P
L
K
V
G
A
V
T
A
P
N
R
V
F
M
A
P
L
T
R
L
R
S
I
E
P
G
D
I
P
T
P
L
M
G
E
Y
Y
R
Q
R
A
--
S
A
G
L
I
I
S
E
A
T
Q
I
S
A
Q
A
K
G
Y
A
G
A
P
G
L
H
S
P
E
Q
I
A
A
W
K
K
I
T
A
G
V
H
A
E
D
G
R
I
A
V
Q
L
W
H
T
G
R
IS
H
S
----------
S
----
I
Q
-
P
----------
G
------------
G
Q
A
P
V
S
A
S
A
L
N
A
N
-
T
R
T
S
L
R
D
ENG
N
A
I
R
V
D
T
T
T
P
R
A
L
E
L
D
E
I
P
G
I
V
N
D
F
R
Q
A
V
A
N
A
R
E
A
G
F
D
L
V
E
L
H
S
A
H
G
Y
L
L
H
Q
F
L
S
P
S
S
N
Q
R
T
D
Q
Y
G
G
S
V
E
N
R
A
R
L
V
L
E
V
V
D
A
V
C
N
E
--
W
--
S
A
D
R
I
G
I
R
V
S
PIG
T
F
Q
N
V
D
N
G
-
P
N
E
E
A
D
A
L
Y
L
I
E
E
L
A
K
R
G
I
A
Y
L
H
M
S
-------
E
T
D
-
L
A
G
G
K
P
Y
S
E
A
F
R
Q
K
V
R
E
R
F
H
G
V
I
I
G
A
G
A
Y
T
-
A
E
K
A
E
D
L
I
G
K
G
L
I
D
A
V
A
F
G
R
D
Y
I
A
N
P
D
L
V
A
R
L
Q
K
K
A
E
L
N
P
Q
-----
R
P
---------
65
PsiBlast_CBE
56.42
32%
8
- C2 -
1GVQ
2
?
A:
[3-347]
--
E
K
L
F
T
P
L
K
V
G
A
V
T
A
P
N
R
V
F
M
A
P
L
T
R
L
R
S
I
E
P
G
D
I
P
T
P
L
M
G
E
Y
Y
R
Q
R
A
--
S
A
G
L
I
I
S
E
A
T
Q
I
S
A
Q
A
K
G
Y
A
G
A
P
G
L
H
S
P
E
Q
I
A
A
W
K
K
I
T
A
G
V
H
A
E
D
G
R
I
A
V
Q
L
W
H
T
G
R
IS
H
S
----------
S
----
I
Q
-
P
----------
G
------------
G
Q
A
P
V
S
A
S
A
L
N
A
N
-
T
R
T
S
L
R
D
ENG
N
A
I
R
V
D
T
T
T
P
R
A
L
E
L
D
E
I
P
G
I
V
N
D
F
R
Q
A
V
A
N
A
R
E
A
G
F
D
L
V
E
L
H
S
A
H
G
Y
L
L
H
Q
F
L
S
P
S
S
N
Q
R
T
D
Q
Y
G
G
S
V
E
N
R
A
R
L
V
L
E
V
V
D
A
V
C
N
E
--
W
--
S
A
D
R
I
G
I
R
V
S
PIG
T
F
Q
N
V
D
N
G
-
P
N
E
E
A
D
A
L
Y
L
I
E
E
L
A
K
R
G
I
A
Y
L
H
M
S
-------
E
T
D
-
L
A
G
G
K
P
Y
S
E
A
F
R
Q
K
V
R
E
R
F
H
G
V
I
I
G
A
G
A
Y
T
-
A
E
K
A
E
D
L
I
G
K
G
L
I
D
A
V
A
F
G
R
D
Y
I
A
N
P
D
L
V
A
R
L
Q
K
K
A
E
L
N
P
Q
-----
R
P
---------