@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4418: (2016-02-27 )
MKLNYFQGALYPWRFCVIVGLLLAMVGAIVWRIVDLHVIDHDFLKGQGDARSVRHIAIPAHRGLITDRNGEPLAVSTPVTTLWANPKELMTAKERWPQLAAALGQDTKLFADRIEQNAEREFIYLVRGLTPEQGEGVIALKVPGVYSIEEFRRFYPAGEVVAHAVGFTDVDDRGREGIELAFDEWLAGVPGKRQVLKDRRGRVIKDVQVTKNAKPGKTLALSIDLRLQYLAHRELRNALLENGAKAGSLVIMDVKTGEILAMTNQPTYNPNNRRNLQPAAMRNRAMIDVFEPGSTVKPFSMSAALASGRWKPSDIVDVYPGTLQIGRYTIRDVSRNSRQLDLTGILIKSSNVGISKIAFDIGAESIYSVMQQVGLGQDTGLGFPGERVGNLPNHRKWPKAETATLAYGYGLSVTAIQLAHAYAALANDGKSVPLSMTRVDRVPDGVQVISPEVASTVQGMLQQVVEAQGGVFRAQVPGYHAAGKSGTARKVSVGTKGYRENAYRSLFAGFAPATDPRIAMVVVIDEPSKAGYFGGLVSAPVFSKVMAGALRLMNVPPDNLPTATEQQQVNAAPAKGGRG
Atome Classification :
(20 SA)
--------------------------------------------------------------.........10........20........30........40...---.....50........60........70........80...---------.....90........100----.......110.....-.--.120......-------.130.......140.......150.......160.......170-.-----------------..--------------......180.......190.......200...-..-..--210...--....220.......230.......240.......250.......260.......270....------------.-..280.......-----------.290.......300.......310......----.320.----......330...-----..-----.-----.340.......350.......360.......370.......380.......390.......400.......410........420.......-----430-.......440.-----------...----------.-.-----------.450.......460..---------..---------.--.---------.470----...-......480.......490.......500........--.--510.......520.......-530.......540.......550......-----.560.......570.......---------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------MK
L
N
YFQGA
L
Y
P
W
R
F
C
V
I
V
G
L
L
L
A
M
V
G
A
I
V
W
R
I
V
D
L
H
VI
D
H
D
F
L---KGQGDAR
S
V
R
H
I
A
IPAHRGLITDRNGE
P
L
A
VSTPVTTLWA---------
N
P
K
E
L
M
T
A
K
E
R
W
P
Q
L
A
A
A
----LGQ
D
T
K
L
F
A
D
R
I
E
QN-A--ER
E
F
I
Y
L
VRG-------LT
P
E
QGE
G
V
I
A
L
KVPGVY
S
I
E
E
F
R
R
FYP
A
G
E
V
V
A
H
AVGFTDV---D-----------------DR--------------GREG
I
E
L
A
F
D
E
W
L
AGVP
G
K
R
Q
V
L
K
D
RRG
R
V
I
K
-
D
V
-
Q
V--TKNAKP--G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
ENGAKAG
S
L
V
I
M
DVKTG
E
I
L
A
MTNQPTYNPNNRRNL------------
Q
-
P
A
A
M-RN
R
A
M
I
D
-----------
V
FEPGSTVKPF
S
M
S
A
A
L
ASGRWKPSD
I
V
DV----YPG
T
L
----
Q
I
G
R
Y
T
I
RDVSR-----NS-----
R
-----
Q
L
D
L
T
G
I
L
I
KSSNVG
I
S
K
I
A
F
DI
G
A
E
S
I
Y
S
V
M
Q
QVGLGQDTGLGF
P
G
E
R
VGNLPNHRKWPKAE
T
A
T
L
A
YGYG-L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
ANDG-----KSV-P
L
S
M
T
R
VDRVP-----------DG
V
----------
Q
-V-----------I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
---------
V
E
---------A--Q---------G
G
------
V
F
R
-AQVPGYHAAGKSGT
A
R
K
V
S
VGTKGY
R
E
--
N
A
Y
R
S
L
F
A--G--FAPATDP
R
I
A
M
V
V
V
IDEPSK-AGYFGGLV
S
A
P
V
F
S
K
V
M
A
G
A
L
R
L
MNVPPD-----NLPTA
T
E
Q
QQVNAAPAKGGRG---------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
98.86
100%
-93
- C1 -
4KQR
10
?
B:
[38-555]
---------------------------------------------------------------------------------------------------------------------
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
---------
N
P
K
E
L
M
T
A
K
E
R
W
P
Q
L
A
A
A
----
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
-
A
--
E
R
E
F
I
Y
L
V
R
G
-------
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
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G
V
Y
S
I
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E
F
R
R
F
Y
P
A
G
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V
V
A
H
A
V
G
F
T
D
V
---
D
-----------------
D
R
--------------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
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Q
V
L
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D
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R
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R
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I
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-
D
V
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N
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P
--
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K
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L
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L
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L
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L
Q
Y
L
A
H
R
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L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
------------
Q
-
P
A
A
M
-
R
N
R
A
M
I
D
-----------
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
----
Y
P
G
T
L
----
Q
I
G
R
Y
T
I
R
D
V
S
R
-----
N
S
-----
R
-----
Q
L
D
L
T
G
I
L
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S
S
N
V
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I
A
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M
Q
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Q
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P
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G
N
L
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K
W
P
K
A
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T
A
T
L
A
Y
G
Y
G
-
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
-----
K
S
V
-
P
L
S
M
T
R
V
D
R
V
P
-----------
D
G
V
----------
Q
-
V
-----------
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
---------
V
E
---------
A
--
Q
---------
G
G
------
V
F
R
-
A
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
S
V
G
T
K
G
Y
R
E
--
N
A
Y
R
S
L
F
A
--
G
--
F
A
P
A
T
D
P
R
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A
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V
V
V
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K
-
A
G
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G
G
L
V
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A
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F
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M
A
G
A
L
R
L
M
N
V
P
P
D
-----
N
L
P
T
A
T
E
Q
Q
Q
V
N
------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
98.64
100%
-91
- C1 -
4KQR
11
?
A:
[36-555]
-------------------------------------------------------------------------------------------------------------------
R
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
---------
N
P
K
E
L
M
T
A
K
E
R
W
P
Q
L
A
A
A
----
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
-
A
--
E
R
E
F
I
Y
L
V
R
G
-------
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
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E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
---
D
-----------------
D
R
--------------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
-
D
V
-
Q
V
--
T
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
------------
Q
-
P
A
A
M
-
R
N
R
A
M
I
D
-----------
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
----
Y
P
G
T
L
----
Q
I
G
R
Y
T
I
R
D
V
S
R
-----
N
S
-----
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
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K
I
A
F
D
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M
Q
Q
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L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
-
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
-----
K
S
V
-
P
L
S
M
T
R
V
D
R
V
P
-----------
D
G
V
----------
Q
-
V
-----------
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
---------
V
E
---------
A
--
Q
---------
G
G
------
V
F
R
-
A
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
S
V
G
T
K
G
Y
R
E
--
N
A
Y
R
S
L
F
A
--
G
--
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
-
A
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
D
-----
N
L
P
T
A
T
E
Q
Q
Q
V
N
------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
98.39
100%
-93
- C1 -
4KQQ
5
?
A:
[36-555]
-------------------------------------------------------------------------------------------------------------------
R
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
---------
N
P
K
E
L
M
T
A
K
E
R
W
P
Q
L
A
A
A
----
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
-
A
--
E
R
E
F
I
Y
L
V
R
G
-------
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
---
D
-----------------
D
R
--------------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
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Q
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D
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I
K
-
D
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Q
V
--
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N
A
K
P
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L
A
L
S
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D
L
R
L
Q
Y
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N
A
L
L
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N
G
A
K
A
G
S
L
V
I
M
D
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K
T
G
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I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
------------
Q
-
P
A
A
M
-
R
N
R
A
M
I
D
-----------
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
----
Y
P
G
T
L
----
Q
I
G
R
Y
T
I
R
D
V
S
R
-----
N
S
-----
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
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A
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M
Q
Q
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L
G
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P
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G
N
L
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R
K
W
P
K
A
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T
A
T
L
A
Y
G
Y
G
-
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
-----
K
S
V
-
P
L
S
M
T
R
V
D
R
V
P
-----------
D
G
V
----------
Q
-
V
-----------
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
---------
V
E
---------
A
--
Q
---------
G
G
------
V
F
R
-
A
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
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V
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V
G
T
K
G
Y
R
E
--
N
A
Y
R
S
L
F
A
--
G
--
F
A
P
A
T
D
P
R
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V
V
V
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K
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A
G
Y
F
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G
L
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A
P
V
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M
A
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A
L
R
L
M
N
V
P
P
D
-----
N
L
P
T
A
T
E
Q
Q
Q
V
N
------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
98.10
100%
-93
- C1 -
4KQO
3
?
A:
[35-547]
------------------------------------------------------------------------------------------------------------------
A
R
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
---------
N
P
K
E
L
M
T
A
K
E
R
W
P
Q
L
A
A
A
----
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
-
A
--
E
R
E
F
I
Y
L
V
R
G
-------
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
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F
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R
F
Y
P
A
G
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V
V
A
H
A
V
G
F
T
D
V
---
D
-----------------
D
R
--------------
G
R
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G
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E
L
A
F
D
E
W
L
A
G
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P
G
K
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D
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L
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L
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L
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N
A
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A
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N
Q
P
T
Y
N
P
N
N
R
R
N
L
------------
Q
-
P
A
A
M
-
R
N
R
A
M
I
D
-----------
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
----
Y
P
G
T
L
----
Q
I
G
R
Y
T
I
R
D
V
S
R
-----
N
S
-----
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
-
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
-----
K
S
V
-
P
L
S
M
T
R
V
D
R
V
P
-----------
D
G
V
----------
Q
-
V
-----------
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
---------
V
E
---------
A
--
Q
---------
G
G
------
V
F
R
-
A
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
S
V
G
T
K
G
Y
R
E
--
N
A
Y
R
S
L
F
A
--
G
--
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
-
A
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
D
-----
N
L
P
T
--------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
97.29
100%
-95
- C1 -
4KQQ
6
?
B:
[42-555]
-------------------------------------------------------------------------------------------------------------------------
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
---------
N
P
K
E
L
M
T
A
K
E
R
W
P
Q
L
A
A
A
----
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
-
A
--
E
R
E
F
I
Y
L
V
R
G
-------
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
---
D
-----------------
D
R
--------------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
-----------------
V
--
T
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
------------
Q
-
P
A
A
M
-
R
N
R
A
M
I
D
-----------
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
----
Y
P
G
T
L
----
Q
I
G
R
Y
T
I
R
D
V
S
R
-----
N
S
-----
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
-
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
-----
K
S
V
-
P
L
S
M
T
R
V
D
R
V
P
-----------
D
G
V
----------
Q
-
V
-----------
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
---------
V
E
---------
A
--
Q
---------
G
G
------
V
F
R
-
A
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
S
V
G
T
K
G
Y
R
E
--
N
A
Y
R
S
L
F
A
--
G
--
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
-
A
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
D
-----
N
L
P
T
A
T
E
Q
Q
Q
V
N
------------------------------------------------------------------------------------------------------------------
55
Fugue
97.18
100%
-95
- C1 -
3OC2
3
?
A:
[35-545]
------------------------------------------------------------------------------------------------------------------
A
R
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
---------
N
P
K
E
L
M
T
A
K
E
R
W
P
Q
L
A
A
A
----
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
-
A
--
E
R
E
F
I
Y
L
V
R
G
-------
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
---
D
-----------------
D
R
--------------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
-
D
V
-
Q
V
--
T
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
------------
Q
-
P
A
A
M
-
R
N
R
A
M
I
D
-----------
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
----
Y
P
G
T
L
----
Q
I
G
R
Y
T
I
R
D
V
S
R
-----
N
S
-----
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
-
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
-----
K
S
V
-
P
L
S
M
T
R
V
D
R
V
P
-----------
D
G
V
----------
Q
-
V
-----------
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
---------
V
E
---------
A
--
Q
---------
G
G
------
V
F
R
-
A
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
-------------
A
Y
R
S
L
F
A
--
G
--
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
------
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
D
-----
N
L
----------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
97.08
100%
-94
- C1 -
3OCN
1
?
A:
[35-545]
------------------------------------------------------------------------------------------------------------------
A
R
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
---------
N
P
K
E
L
M
T
A
K
E
R
W
P
Q
L
A
A
A
----
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
-
A
--
E
R
E
F
I
Y
L
V
R
G
-------
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
---
D
-----------------
D
R
--------------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
-
D
V
-
Q
V
--
T
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
------------
Q
-
P
A
A
M
-
R
N
R
A
M
I
D
-----------
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
----
Y
P
G
T
L
----
Q
I
G
R
Y
T
I
R
D
V
S
R
-----
N
S
-----
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
-
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
-----
K
S
V
-
P
L
S
M
T
R
V
D
R
V
P
-----------
D
G
V
----------
Q
-
V
-----------
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
---------
V
E
---------
A
--
Q
---------
G
G
------
V
F
R
-
A
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
--------
E
--
N
A
Y
R
S
L
F
A
--
G
--
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
-
A
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
D
-----
N
L
----------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
95.81
100%
-95
- C1 -
4KQO
5
?
B:
[43-548]
--------------------------------------------------------------------------------------------------------------------------
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
---------
N
P
K
E
L
M
T
A
K
E
R
W
P
Q
L
A
A
A
----
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
-
A
--
E
R
E
F
I
Y
L
V
R
G
-------
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
---
D
-----------------
D
R
--------------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
------------------
V
--
T
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
------------
Q
-
P
A
A
M
-
R
N
R
A
M
I
D
-----------
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
----
Y
P
G
T
L
----
Q
I
G
R
Y
T
I
R
D
V
S
R
-----
N
S
-----
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
-
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
-----
K
S
V
-
P
L
S
M
T
R
V
D
R
V
P
-----------
D
G
V
----------
Q
-
V
-----------
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
---------
V
E
---------
A
--
Q
---------
G
G
------
V
F
R
-
A
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
S
V
G
T
K
G
Y
R
E
--
N
A
Y
R
S
L
F
A
--
G
--
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
-
A
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
D
-----
N
L
P
T
A
-------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
72.22
38%
-69
- C1 -
3EQV
9
PBP2_NEIGO
A:
[14-534]
-----------------------------------------------------------------------------------------------------
T
Y
N
F
L
---
K
E
Q
G
D
N
R
I
V
R
T
Q
A
L
P
A
T
R
G
T
V
S
D
R
N
G
A
V
L
A
L
S
A
P
T
E
--------------------------------------------------------------------------------------------
E
L
K
R
H
Y
P
M
G
N
L
F
A
H
V
I
G
F
T
D
I
---
D
-----------------
G
K
--------------
G
Q
E
G
L
E
L
S
L
E
D
S
L
Y
G
E
D
G
A
E
V
V
L
R
D
R
Q
G
N
I
V
D
-
S
L
-
D
S
--
P
R
N
K
A
P
Q
N
G
K
D
I
I
L
S
L
D
Q
R
I
Q
T
L
A
Y
E
E
L
N
K
A
V
E
Y
H
Q
A
K
A
G
T
V
V
V
L
D
A
R
T
G
E
I
L
A
L
A
N
T
P
A
Y
D
P
N
R
P
G
R
A
------------
D
-
S
E
Q
R
-
R
N
R
A
V
T
D
-----------
M
I
E
P
G
S
A
I
K
P
F
V
I
A
K
A
L
D
A
G
K
T
D
L
N
E
R
L
N
T
----
Q
P
--
Y
----
K
I
G
P
S
P
V
R
D
-
T
H
-----
V
Y
-----
P
-----
S
L
D
V
R
G
I
M
Q
K
S
S
N
V
G
T
S
K
L
S
A
R
F
G
A
E
E
M
Y
D
F
Y
H
E
L
G
I
G
V
R
M
H
S
G
F
P
G
E
T
A
G
L
L
R
N
W
R
R
W
R
P
I
E
Q
A
T
M
S
F
G
Y
G
-
L
Q
L
S
L
L
Q
L
A
R
A
Y
T
A
L
T
H
D
G
-----
V
L
L
-
P
L
S
F
E
K
Q
A
V
A
P
-----------
Q
G
K
----------
R
-
I
-----------
F
K
E
S
T
A
R
E
V
R
N
L
M
V
S
V
---------
T
E
---------
P
--
G
---------
G
T
------
G
T
A
-
G
A
V
D
G
F
D
V
G
A
K
T
G
T
A
R
K
------------
N
K
H
V
G
T
F
I
--
G
--
F
A
P
A
K
N
P
R
V
I
V
A
V
T
I
D
E
P
T
A
-
H
G
Y
Y
G
G
V
V
A
G
S
P
F
K
K
I
M
G
G
S
L
N
I
L
G
I
S
P
T
-----
K
P
L
T
--------------------------------------------------------------------------------------------------------------------------
31
HHSearch
71.11
39%
-77
- C1 -
3EQU
11
PBP2_NEIGO
A:
[24-534]
------------------------------------------------------------------------------------------------------------------
N
R
I
V
R
T
Q
A
L
P
A
T
R
G
T
V
S
D
R
N
G
A
V
L
A
L
S
A
P
T
E
---------------------------------------------------------------------------------------------
L
K
R
H
Y
P
M
G
N
L
F
A
H
V
I
G
F
T
D
I
---
D
-----------------
G
K
--------------
G
Q
E
G
L
E
L
S
L
E
D
S
L
Y
G
E
D
G
A
E
V
V
L
R
D
R
Q
G
N
I
V
D
-
S
L
-
D
S
PR
N
K
A
P
Q
N
--
G
K
D
I
I
L
S
L
D
Q
R
I
Q
T
L
A
Y
E
E
L
N
K
A
V
E
Y
H
Q
A
K
A
G
T
V
V
V
L
D
A
R
T
G
E
I
L
A
L
A
N
T
P
A
Y
D
P
N
R
P
G
R
A
------------
D
-
S
E
Q
R
-
R
N
R
A
V
T
D
-----------
M
I
E
P
G
S
A
I
K
P
F
V
I
A
K
A
L
D
A
G
K
T
D
L
N
E
R
L
N
T
----
Q
--
P
Y
----
K
I
G
P
S
P
V
R
D
T
-
H
-----
V
Y
-----
P
-----
S
L
D
V
R
G
I
M
Q
K
S
S
N
V
G
T
S
K
L
S
A
R
F
G
A
E
E
M
Y
D
F
Y
H
E
L
G
I
G
V
R
M
H
S
G
F
P
G
E
T
A
G
L
L
R
N
W
R
R
W
R
P
I
E
Q
A
T
M
S
F
G
Y
G
-
L
Q
L
S
L
L
Q
L
A
R
A
Y
T
A
L
T
H
D
G
-----
V
L
L
-
P
L
S
F
E
K
Q
A
V
A
P
-----------
Q
G
K
----------
R
-
I
-----------
F
K
E
S
T
A
R
E
V
R
N
L
M
V
S
V
---------
T
E
---------
P
--
G
---------
G
T
------
G
T
A
-
G
A
V
D
G
F
D
V
G
A
K
T
G
T
A
---------------
K
H
V
A
T
F
I
--
G
--
F
A
P
A
K
N
P
R
V
I
V
A
V
T
I
D
E
P
T
A
-
H
G
Y
Y
G
G
V
V
A
G
P
P
F
K
K
I
M
G
G
S
L
N
I
L
G
I
S
P
T
-----
K
P
L
T
--------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
71.11
38%
-76
- C1 -
3EQU
11
PBP2_NEIGO
A:
[24-534]
------------------------------------------------------------------------------------------------------------------
N
R
I
V
R
T
Q
A
L
P
A
T
R
G
T
V
S
D
R
N
G
A
V
L
A
L
S
A
P
T
E
---------------------------------------------------------------------------------------------
L
K
R
H
Y
P
M
G
N
L
F
A
H
V
I
G
F
T
D
I
---
D
-----------------
G
K
--------------
G
Q
E
G
L
E
L
S
L
E
D
S
L
Y
G
E
D
G
A
E
V
V
L
R
D
R
Q
G
N
I
V
D
-
S
L
-
D
S
--
P
R
N
K
A
P
Q
N
G
K
D
I
I
L
S
L
D
Q
R
I
Q
T
L
A
Y
E
E
L
N
K
A
V
E
Y
H
Q
A
K
A
G
T
V
V
V
L
D
A
R
T
G
E
I
L
A
L
A
N
T
P
A
Y
D
P
N
R
P
G
R
A
------------
D
-
S
E
Q
R
-
R
N
R
A
V
T
D
-----------
M
I
E
P
G
S
A
I
K
P
F
V
I
A
K
A
L
D
A
G
K
T
D
L
N
E
R
L
N
T
----
Q
P
--
Y
----
K
I
G
P
S
P
V
R
D
-
T
H
-----
V
Y
-----
P
-----
S
L
D
V
R
G
I
M
Q
K
S
S
N
V
G
T
S
K
L
S
A
R
F
G
A
E
E
M
Y
D
F
Y
H
E
L
G
I
G
V
R
M
H
S
G
F
P
G
E
T
A
G
L
L
R
N
W
R
R
W
R
P
I
E
Q
A
T
M
S
F
G
Y
G
-
L
Q
L
S
L
L
Q
L
A
R
A
Y
T
A
L
T
H
D
G
-----
V
L
L
-
P
L
S
F
E
K
Q
A
V
A
P
-----------
Q
G
K
----------
R
-
I
-----------
F
K
E
S
T
A
R
E
V
R
N
L
M
V
S
V
---------
T
E
---------
P
--
G
---------
G
T
------
G
T
A
-
G
A
V
D
G
F
D
V
G
A
K
T
G
T
A
---------------
K
H
V
A
T
F
I
--
G
--
F
A
P
A
K
N
P
R
V
I
V
A
V
T
I
D
E
P
T
A
-
H
G
Y
Y
G
G
V
V
A
G
P
P
F
K
K
I
M
G
G
S
L
N
I
L
G
I
S
P
T
-----
K
P
L
T
--------------------------------------------------------------------------------------------------------------------------
57
Fugue
68.72
27%
-62
- C1 -
1QME
3
PBPX_STRPN
A:
[23-702]
-------------------------------------------------------------------------------------------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
----------------------------------------------------------------------------------------------
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
---
H
-----------------
E
N
EDG
S
K
S
L
L
------
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
------------------------
R
T
M
D
--
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
------------
T
-
E
D
F
V
W
R
D
I
L
Y
Q
S
-----------
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
--
V
F
----
N
S
S
E
L
----
K
I
A
D
A
T
I
R
D
W
D
V
-----
N
E
-----
G
LTG
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
---
I
V
N
I
A
Q
S
S
F
G
Q
G
-
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
-----
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
N
-----------
D
Q
T
A
R
K
S
Q
K
EIVG
N
-
P
-----------
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
---------
G
T
DPVYGTMYN
H
--
S
---------
T
G
------
K
P
T
-
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
GL
T
D
Y
I
F
S
A
V
--
S
--
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
D
S
L
N
----------------
L
Q
Q
S
P
Y
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
TGTKIKNSSAEEGKNLAPN
Q
Q
V
L
I
L
S
DKAEEVPDMYGWT
K
E
T
A
E
T
L
A
K
W
L
N
I
E
L
E
F
Q
G
SGSTVQKQDVRANTAIKDIK
K
I
T
L
T
L
G
D
9
PsiBlast_PDB
67.58
23%
-65
- C1 -
1RP5
1
PBPX_STRPN
A:
[23-565]
-------------------------------------------------------------------------------------------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
S
Y
N
V
Y
A
V
IDENYKSA
T
G
K
I
L
Y
V
E
K
T
Q
F
N
K
V
A
E
V
F
H
K
Y
L
D
M
E
E
S
Y
V
R
E
Q
L
S
Q
P
-
N
--
L
K
Q
V
S
F
G
A
K
G
NGIT
Y
A
N
M
M
S
I
K
K
E
L
E
T
A
-
E
V
K
G
I
D
F
T
T
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
---
H
-----------------
E
N
EDG
S
K
S
L
L
------
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
I
I
T
Y
E
K
D
R
L
G
N
I
V
P
-
G
T
E
Q
V
--
S
Q
Q
T
V
D
--
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T-----------
E
-
D
F
V
W
-
R
D
I
L
Y
Q
S
-----------
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
------
S
S
E
L
----
K
I
A
D
A
T
I
R
D
W
D
V
-----
N
E
GLTG
G
R
-----
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
I
---
V
N
I
A
M
S
A
F
G
Q
G
-
I
S
V
T
Q
T
Q
M
L
R
A
F
T
A
I
A
N
D
G
-----
V
M
L
-
E
P
K
F
I
S
A
L
Y
D
P
-----------
N
D
Q
----------
S
-
V
R
K
S
Q
KEIVGNP
V
S
K
E
A
A
S
V
T
R
D
H
M
V
M
V
GTDPTYGTM
Y
N
---------
H
--
S
---------
T
G
------
K
A
T
-
V
N
V
P
G
Q
N
V
A
L
K
S
G
T
A
E
I
A
D
E
K
N
G
G
Y
L
T
--
G
S
T
N
N
I
F
S
V
V
S
--
M
H
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
----------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
67.37
25%
-59
- C1 -
1QME
3
PBPX_STRPN
A:
[23-702]
-------------------------------------------------------------------------------------------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
----------------------------------------------------------------------------------------------
V
P
I
A
E
D
A
T
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
---
H
-----------------
E
N
EDG
S
K
S
L
L
------
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
R
------------------------
T
M
D
--
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
------------
T
-
E
D
F
V
W
R
D
I
L
Y
Q
S
-----------
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
------
S
S
E
L
----
K
I
A
D
A
T
I
R
D
W
D
V
-----
N
E
-----
G
LTG
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
---
I
V
N
I
A
Q
S
S
F
G
Q
G
-
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
-----
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
N
-----------
D
Q
T
----------
A
-
R
K
S
Q
K
EIVGNP-
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
---------
G
T
---------
D
--
P
VYGTMYNHS
T
G
------
K
P
T
-
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
GL
T
D
Y
I
F
S
A
V
--
S
--
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
----
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
D
S
L
N
L
Q
Q
S
P
Y
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
TGTKIKNSSAEEGKNLAPN
Q
Q
V
L
I
L
S
DKAEEVPDMYGWT
K
E
T
A
E
T
L
A
K
W
L
N
I
E
L
E
F
Q
G
SGSTVQKQDVRANTAIKDIK
K
I
T
L
T
L
G
D------------
35
HHSearch
64.21
24%
-65
* C1 *
1QME
3
PBPX_STRPN
A:
[23-577]
-------------------------------------------------------------------------------------------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
----------------------------------------------------------------------------------------------
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
---
H
E
N
EDG
S
K
S
---------
L
L
--------------
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
------------------------
R
T
M
D
--
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
------------
T
E
D
F
V
W
-
R
D
I
L
Y
Q
S
-----------
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
----
S
--
E
L
----
K
I
A
D
A
T
I
R
D
W
D
V
N
E
GLT
G
G
-----
R
-----
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
---
N
I
V
N
I
A
Q
S
S
F
G
Q
G
-
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
-----
V
M
L
-
E
P
K
F
I
S
A
I
Y
D
P
NDQ
T
A
R
K
S
Q
K
E
I
V
G
----------
N
-
P
-----------
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
---------
G
T
---------
D
PV
Y
---------
G
T
MYNHST
G
K
P
T
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
GL
T
D
Y
I
F
S
A
V
--
S
--
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
----
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
-----------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
63.58
39%
-77
- C1 -
4U3T
-
PBP2_NEIGO
A:
[5-330]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
D
Q
R
I
Q
T
L
A
Y
E
E
L
N
K
A
V
E
Y
H
Q
A
K
A
G
T
V
V
V
L
D
A
R
T
G
E
I
L
A
L
A
N
T
P
G
----------------------------
R
N
R
A
V
T
D
-----------
M
I
E
P
G
S
A
I
K
P
F
V
I
A
K
A
L
D
A
G
K
T
D
L
N
E
R
L
N
T
----
Q
P
--
Y
----
K
I
G
P
S
P
V
R
D
D
T
H
-----
V
Y
-----
P
-----
S
L
D
V
R
G
I
M
Q
K
S
S
N
V
G
T
S
K
L
S
A
R
F
G
A
E
E
M
Y
D
F
Y
H
E
L
G
I
G
V
R
M
H
S
G
F
P
G
E
T
A
G
L
L
R
N
W
R
R
W
R
P
I
E
Q
A
T
M
S
F
G
Y
G
-
L
Q
L
S
L
L
Q
L
A
R
A
Y
T
A
L
T
H
D
G
-----
V
L
L
-
P
L
S
F
E
K
Q
A
V
A
P
-----------
Q
G
K
----------
R
-
I
-----------
F
K
E
S
T
A
R
E
V
R
N
L
M
V
S
V
---------
T
E
---------
P
--
G
---------
G
T
------
G
T
A
-
G
A
V
D
G
F
D
V
G
A
K
T
G
T
A
R
K
L
V
N
G
R
--
Y
V
D
--
N
K
H
V
G
T
F
I
--
G
--
F
A
P
A
K
N
P
R
V
I
V
A
V
T
I
D
E
P
T
A
-
H
G
----
V
V
A
G
S
P
F
K
K
I
M
G
G
S
L
N
I
L
G
I
S
P
T
-----
K
P
L
T
A
-------------------------------------------------------------------------------------------------------------------------
33
HHSearch
62.40
20%
-65
- C1 -
1VQQ
9
?
A:
[98-638]
--------------------------------------------------------------------------------------------
D
G
M
W
K
L
D
W
D
H
S
V
I
I
---
P
G
M
Q
K
D
Q
S
I
H
I
E
N
L
K
S
E
R
G
K
I
L
D
R
N
N
V
E
L
A
N
T
G
T
A
Y
E
I
G
I
---------
V
P
K
N
V
S
--
K
K
D
Y
K
A
I
A
K
E
----
L
S
I
S
E
D
Y
I
K
Q
Q
M
D
Q
N
-
W
VQ
D
D
T
F
V
P
L
K
T
--------
V
K
K
M
D
E
Y
L
S
D
F
A
K
K
F
H
L
T
T
N
E
T
E
S
R
N
Y
P
L
E
K
A
T
S
H
L
L
G
Y
V
G
P
---
I
N
S
E
E
L
K
QKEYKGYKD
D
A
V
I
--------------
G
K
K
G
L
E
K
L
Y
D
K
K
L
Q
H
E
D
G
Y
R
V
T
I
V
D
D
-
S
N
T
I
A
H
T
L
-
I
---
E
K
K
K
K
D
--
G
K
D
I
Q
L
T
I
D
A
K
V
Q
K
S
I
Y
N
N
M
K
-------
N
D
Y
G
S
G
T
A
I
H
P
Q
T
G
E
L
L
A
L
V
S
T
P
S
Y
D
V
Y
P
F
M
Y
G
MS
N
E
E
Y
N
K
L
T
E
D
K
-
K
E
P
L
-
L
N
K
F
-
Q
I
-----------
T
T
S
P
G
S
T
Q
K
I
L
T
A
M
I
G
L
N
N
K
T
L
D
D
K
T
S
Y
K
I
----
D
G
K
G
W
QKDK
S
W
G
G
Y
N
V
T
R
Y
E
V
-----
V
N
-----
G
-----
N
I
D
L
K
Q
A
I
E
S
S
D
N
I
F
F
A
R
V
A
L
E
L
G
S
K
K
F
E
K
G
M
K
K
L
G
V
G
E
D
I
P
S
D
Y
P
F
Y
N
A
-
Q
I
S
N
K
N
L
D
N
E
I
L
L
A
D
S
G
Y
G
Q
G
E
I
L
I
N
P
V
Q
I
L
S
I
Y
S
A
L
E
N
N
G
-----
N
I
N
-
A
P
H
L
L
K
D
T
K
N
K
V
----------
W
K
K
----------
N
-
I
-----------
I
S
K
E
N
I
N
L
L
T
D
G
M
Q
Q
V
---------
V
N
------------
K
---------
T
H
------
K
E
D
-
I
Y
R
S
Y
A
N
L
I
G
K
S
G
T
A
E
L
K
-----------
G
R
Q
I
G
W
F
I
--
S
--
Y
D
K
D
-
N
P
N
M
M
M
A
I
N
V
K
D
V
Q
D
-
K
--
G
M
A
S
Y
N
A
K
I
S
G
K
V
Y
D
E
L
Y
E
N
G
----------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
62.04
23%
-65
- C1 -
1PYY
2
PBPX_STRR6
A:
[25-565]
---------------------------------------------------------------------------------------------------------------------------
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
S
Y
N
V
Y
A
---------------------
N
K
V
A
E
V
F
H
K
Y
L
D
M
E
E
S
Y
V
R
E
Q
L
----------
V
S
F
G
A
K
G
NGITYAN
M
M
S
-------------------
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
---
H
-----------------
E
N
EDG
S
K
S
L
L
------
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
----------------------------
D
--
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T-----------
E
-
D
F
V
W
-
R
D
I
L
Y
Q
S
-----------
N
Y
E
P
G
S
A
F
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
------
S
S
E
L
----
K
I
A
D
A
T
I
R
D
W
D
V
-----
N
E
GLTGG
R
-----
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
I
V
N
I
A
Q
S
---
S
F
G
Q
G
-
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
-
S
A
I
Y
D
P
N
D
Q
T
A
-----------
R
K
S
----------
Q
-
K
EIVGNP-----
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
GTDPVYGTM
Y
N
---------
H
--
S
---------
T
G
------
K
P
T
-
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
--
G
L
T
D
Y
I
F
S
--
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
----------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
61.64
23%
-60
- C1 -
1QME
3
PBPX_STRPN
A:
[23-576]
-------------------------------------------------------------------------------------------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
----------------------------------------------------------------------------------------------
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
---
H
-----------------
E
N
EDG
S
K
S
L
L
------
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
------------------------
R
T
M
D
--
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T-----------
E
-
D
F
V
W
-
R
D
I
L
Y
Q
S
-----------
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
------
S
S
E
L
----
K
I
A
D
A
T
I
R
D
W
D
V
-----
N
E
GLTG
G
R
-----
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
I
V
N
I
A
Q
S
---
S
F
G
Q
G
-
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
-
S
A
I
Y
D
P
N
D
Q
T
A
-----------
R
K
S
----------
Q
-
K
EIVGNP-----
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
GTDPVYGTM
Y
N
---------
H
--
S
---------
T
G
------
K
P
T
-
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
--
G
L
T
D
Y
I
F
S
--
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
----------------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
60.55
19%
-69
- C1 -
4DKI
13
?
A:
[3-646]
SKD
K
E
I
N
N
T
I
D
A
I
E
D
KN
F
K
Q
V
Y
K
D
SS
Y
I
S
K
S
D
N
GEVEMT
E
R
P
I
K
I
Y
N
S
L
GVKDINIQD
R
K
I
K
K
V
S
K
N
K
K
R
V
D
A
Q
Y
K
I
K
T
N
Y
G
N
I
D
R
N
V
Q
F
N
F
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