Atome 2 Filter

@TOME V2.3
(Nov 2016)

Ref. - - Doc.

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Values color: [ Good | Correct | Middling | Bad ]

Sequence color : MutatedHelixStrandConserved

Query sequence : PF00069_CDK5_R: (2014-08-15 )
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSLLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP

Atome Classification :

	(20 SA)									.........10........20....--....30........40........50........60........70-.-----.------.-----.------.....80........90.-.---.----.-....100.......110.......120.......130..----...-..140.......150.......160.......170.......180.......190.....----------..200.....-------.----.210.......220.......230.--.---..-..----.240.........250----.-.......260.......270.......280.......290
		(Atome)	(Ident)	(Tito)	(Num)		(Ligand)	(Uniprot)		MQKYEKLEKIGEGTYGTVFKAKNRE--THEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVL--H-----S------D-----K------KLTLVFEFCDQDLKKYFD-S---C----N-GDLDPEIVKSLLFQLLKGLGFCHSRNVLHRDLKPQNLLI----NRN-GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELAN----------AGRPLFPGND-------V----DDQLKRIFRLLGTPTEEQWPAMTKL--P---DY-KP----YP--MYPATTSLVN-V----V-PKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
23	PsiBlast_CBE	93.60	99%	-117	- C1 -	4AU8		CDK5_HUMAN	B:[6-293]	-QKYEKLEKIGEGTYGTVFKAKNRE--THEIVALKRVRL----EGVPSSALREICLLKELKHKNIVRLHDVL--H-----S------------K------KLTLVFEFCDQDLKKYFD-S---C----N-GDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLI----NRN-GELKLADFGLARAFGIPV------VVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELAN----------AGRPLFPGND-------V----DDQLKRIFRLLGTPTEEQWPSMTKL--P---DY-KP----YP--MYPATTSLVN-V----V-PKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF---
34	HHSearch	92.39	99%	-113	- C1 -	4AU8		CDK5_HUMAN	A:[6-293]	-QKYEKLEKIGEGTYGTVFKAKNRE--THEIVALKRV---------PSSALREICLLKELKHKNIVRLHDVL--H-------------------------KLTLVFEFCDQDLKKYFD-S---C----N-GDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLI----NRN-GELKLADFGLARAFGIPVR--SAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELAN----------AGRPLFPGND-------V----DDQLKRIFRLLGTPTEEQWPSMTKL--P---DY-KP----YP--MYPATTSLVN-V----V-PKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF---
21	PsiBlast_CBE	90.51	98%	-126	- C1 -	3O0G		CDK5_HUMAN	B:[6-288]	-----KLEKIG-----TVFKA--------EIVALKRVR--------PSSALREICLLKELKHKNIVRLHDVL--H-----S------D-----K------KLTLVFEFCDQDLKKYFD-S---C----N-GDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLI----NRN-GELKLANFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELAN----------AGRPLFPGND-------V----DDQLKRIFRLLGTPTEEQWPSMTKL--P---DY-KP----YP--MYPATTSLVN-V----V-PKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD----
20	PsiBlast_PDB	82.84	59%	-116	- C1 -	3QQF		CDK2_HUMAN	A:[9-300]	MENFQKVEKIGEGTYGVVYKARNKL--TGEVVALKKIR----TEGVPSTAIREISLLKELNHPNIVKLLDVI--H-----T------E-----N------KLYLVFEFLHQDLKKFMDAS---A----L-TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLI----NTE-GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT----------R-RALFPGDS-------E----IDQLFRIFRTLGTPDEVVWPGVTSM--P---DY-KP----SF--PKWARQDFSK-V----V-PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP
19	PsiBlast_PDB	82.06	59%	-110	- C1 -	3QL8		CDK2_HUMAN	A:[9-300]	MENFQKVEKIGEGTYGVVYKARNKL--TGEVVALKKIR----TEGVPSTAIREISLLKELNHPNIVKLLDVI--H-----T------E-----N------KLYLVFEFLHQDLKKFMDAS---A----L-TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLI----NTE-GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT----------R-RALFPGDS-------E----IDQLFRIFRTLGTPDEVVWPGVTSM--P---DY-KP----SF--PKWARQDFSK-V----V-PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP
12	PsiBlast_PDB	81.72	59%	-110	- C1 -	3PXF		CDK2_HUMAN	A:[9-300]	MENFQKVEKIGEGTYGVVYKARNKL--TGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVI--H-----T------E-----N------KLYLVFEFLHQDLKKFMDAS---A----L-TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLI----NTE-GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT----------R-RALFPGDS-------E----IDQLFRIFRTLGTPDEVVWPGVTSM--P---DY-KP----SF--PKWARQDFSK-V----V-PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP
15	PsiBlast_PDB	81.65	59%	-109	- C1 -	3PXY		CDK2_HUMAN	A:[9-300]	MENFQKVEKIGEGTYGVVYKARNKL--TGEVVALKKIR----TEGVPSTAIREISLLKELNHPNIVKLLDVI--H-----T------E-----N------KLYLVFEFLHQDLKKFMDAS---A----L-TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLI----NTE-GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT----------R-RALFPGDS-------E----IDQLFRIFRTLGTPDEVVWPGVTSM--P---DY-KP----SF--PKWARQDFSK-V----V-PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP
17	PsiBlast_PDB	81.37	59%	-108	- C1 -	3PY0		CDK2_HUMAN	A:[9-300]	MENFQKVEKIGEGTYGVVYKARNKL--TGEVVALKKIR----TEGVPSTAIREISLLKELNHPNIVKLLDVI--H-----T------E-----N------KLYLVFEFLHQDLKKFMDAS---A----L-TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLI----NTE-GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT----------R-RALFPGDS-------E----IDQLFRIFRTLGTPDEVVWPGVTSM--P---DY-KP----SF--PKWARQDFSK-V----V-PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP
16	PsiBlast_PDB	81.33	59%	-112	- C1 -	3PXZ		CDK2_HUMAN	A:[9-300]	MENFQKVEKIGEGTYGVVYKARNKL--TGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVI--H-----T------E-----N------KLYLVFEFLHQDLKKFMDAS---A----L-TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLI----NTE-GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT----------R-RALFPGDS-------E----IDQLFRIFRTLGTPDEVVWPGVTSM--P---DY-KP----SF--PKWARQDFSK-V----V-PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP
44	HHSearch	80.57	59%	-109	- C1 -	3NIZ		?	A:[20-309]	MEKYQKLEKVGEGTYGVVYKAKD-S--QGRIVALKRIR------GIPSTAIREISLLKELHHPNIVSLIDVI--H-----S------E-----R------CLTLVFEFMEKDLKKVLD-E---N----K-TGLQDSQIKIYLYQLLRGVAHCHQHRILHRDLKPQNLLI----NSD-GALKLADFGLARAFGIPVR---HEVVTLWYRAPDVLMGSKKYSTSVDIWSIGCIFAEMIT-----------GKPLFPGVT-------D----DDQLPKIFSILGTPNPREWPQVQEL--P---LW-KQRT--FQ--VFE-KKPWSS-I----I-PGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDLDP-
13	PsiBlast_PDB	80.36	59%	-106	- C1 -	3PXQ		CDK2_HUMAN	A:[9-300]	MENFQKVEKIGEGTYGVVYKARNKL--TGEVVALKKIR----TEGVPSTAIREISLLKELNHPNIVKLLDVI--H-----T------E-----N------KLYLVFEFLHQDLKKFMDAS---A----L-TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLI----NTE-GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT----------R-RALFPGDS-------E----IDQLFRIFRTLGTPDEVVWPGVTSM--P---DY-KP----SF--PKWARQDFSK-V----V-PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP
18	PsiBlast_PDB	79.93	59%	-105	- C1 -	3PY1		CDK2_HUMAN	A:[9-300]	MENFQKVEKIGEGTYGVVYKARNKL--TGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVI--H-----T------E-----N------KLYLVFEFLHQDLKKFMDAS---A----L-TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLI----NTE-GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT----------R-RALFPGDS-------E----IDQLFRIFRTLGTPDEVVWPGVTSM--P---DY-KP----SF--PKWARQDFSK-V----V-PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP
41	HHSearch	71.10	41%	-101	- C1 -	3N9X		?	A:[26-370]	-DNYIIKHLIGRGSYGYVYLAYDKN--TEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLYDLI--I-----P------DDLLKFD------ELYIVLEIADSDLKKLFK-T--------P-IFLTEEHIKTILYNLLLGENFIHESGIIHRDLKPANCLL----NQD-CSVKVCDFGLARTI---------HVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLFPGSSCFPHEKSN----RDQLNIIFNIIGTPTEDDLKNINKP--EVI-KYIKL----FP--HRK-PINLKQ-K----Y-PSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVRK-
56	HHSearch	70.55	39%	-108	- C1 -	2B9H		FUS3_YEAST	A:[11-314]	-SDFQLKSLLGEGAYGVVCSATHKP--TGEIVAIKKIEPFD-KPLFALRTLREIKILKHFKHENIITIFNIQ--RPDSFEN------F-----N------EVYIIQELMQTDLHRVIS-T----------QMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLI----NSN-CDLKVCDFGLARIID------VEFVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-----------RRPIFPGRD-------Y----RHQLLLIFGIIGTPHSDNDLRCIES--PRAREYIKS----LP--MYPA-APLEK-M----F-PRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHD-
57	HHSearch	69.65	36%	-115	- C1 -	1J1B		GSK3B_HUMAN	A:[55-344]	--SYTDTKVIGNGSFGVVYQAKLCD--SGELVAIKKVLQDKRF------KNRELQIMRKLDHCNIVRLRYFF--Y-----SSGEKKDE-----V------YLNLVLDYVPETVYRVAR-HYSRA----K-QTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL----DPDTAVLKLCDFGSAKQLVRGEP-NVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-----------GQPIFPGDS-------G----VDQLVEIIKVLGTPTREQIREMN----P---NY-TEFK--FP--QIKA-HPWTK-V----FRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELR--
36	HHSearch	69.32	46%	-98	- C1 -	1UA2		CDK7_HUMAN	A:[13-299]	----EKLDFLGEGQFATVYKARDKN--TNQIVAIKKI---------NRTALREIKLLQELSHPNIIGLLDAF--G-----H------K-----S------NISLVFDFMETDLEVIIK-D---N----S-LVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLL----DEN-GVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-----------RVPFLPGDS-------D----LDQLTRIFETLGTPTEEQWPDMCSL--P---DY-VT----FK--SFPG-IPLHH-I----F-SAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRP--
50	HHSearch	67.07	41%	-107	- C1 -	4BGQ		CDKL5_HUMAN	A:[11-301]	MNKFEILGVVGEGAYGVVLKCRHKE--THEIVAIKKFK-------VKETTLRELKMLRTLKQENIVELKEAF--R-----R------R-----G------KLYLVFEYVEKNMLELLE-E---M----P-NGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLI----SHN-DVLKLCDFGFARNLSE----------TRWYRSPELLLG-APYGKSVDMWSVGCILGELSD-----------GQPLFPGES-------E----IDQLFTIQKVLGPLPSEQMKLFYSN--P---RF-HGLR--FP--AVNHPQSLERRY----L-GILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ---
53	HHSearch	66.49	42%	-113	- C1 -	4F6U		CDK8_HUMAN	A:[27-341]	-------CKVGRGTYGHVYKAKRKDGKDDKDYALKQIE----GTGISMSACREIALLRELKHPNVISLQKVFLSH-----A------D-----R------KVWLLFDYAEHDLWHIIK-F---HRASK--VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPER-GRVKIADMGF--------------VVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-----------SEPIFHCRQ-------ENPYHHDQLDRIFNVMGFPADKDWEDIKKM--P---EH-STLMKDFRRNTYT-NCSLIK-YMEKHK-VKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDP--
52	HHSearch	62.22	37%	-106	- C1 -	2FST		MK14_HUMAN	X:[29-320]	-ERYQNLSPVG----GSVCAAFDTK--TGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVF--T-----P------A-----RSLEEFNDVYLVTHLMGADLN----------------QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV----NED-CELKILD------------------ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-----------GRTLFPGTD-------H----IDQLKLILRLVGTPGAELLKKISSESAR---NYIQS----LT--QMP-KMNFAN-V----F-IGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHD-
37	HHSearch	35.67	60%	20	- C1 -	4EK4		CDK2_HUMAN	A:[4-293]	MENFQKVEKIGEGTYGVVYKARNKL--TGEVVALKKI---------PSTAIREISLLKELNHPNIVKLLDVI--H-----T------E-----N------KLYLVFEFLHQDLKKFMD-A---S----ALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLI----NTE-GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-----------RRALFPGDS-------E----IDQLFRIFRTLGTPDEVVWPGVTSM--P---DY-KPS---FP--KWA-RQDFSK-V----V-PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP