@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00089_UROK_H: (2014-08-24 )
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
Atome Classification :
(48 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300...---....310.......320.......330.......340.......350--........360.......370.......380..-.....390.....--..400.......410.......420.......430
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
A
L
L
A
R
L
L
L
C
V
L
VVSDSKGS
N
E
L
H
QVPSNCDCLNG
G
T
CVSNKYFSNIHWCNC
P
K
K
FGGQHCEIDKSK
T
C
YEGNG
H
F
YRGKASTDTMGRPCLPWN
S
A
T
V
L
Q
Q
T
Y
H
A
H
RSD
A
L
Q
LGLGKHNYCRNPDNRRR
P
W
C
Y
V
QVG
L
K
P
L
V
Q
E
C
M
V
HDCADGKKPSS
P
P
E
E
L
K
F
Q
CGQKTLRP
R
F
K
I
IG
G
E
F
T
TIENQ
P
W
F
A
A
I
Y
R
RHRGG
S
V
T
Y
V
CGGSLIS
P
C
W
V
I
S
A
T
H
C
F
IDYPKKE
D
Y
I
V
Y
LGRSRLNSNTQG
E
M
K
F
E
V
E
N
L
I
L
HKDYSADTLAHHN
D
I
A
L
L
K
I
RSKEGRCAQPSR
T
I
Q
T
I
CLPSMYN---DPQFGTS
C
E
I
T
GFGKENSTDYL
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
ECQQPHYY---G
S
E
V
T
T
K
M
L
CAADPQWKTDSCQGDSGG
P
L
V
C
S
L-QG
R
M
T
L
T
G
I
V
SWG--RGCALKDKP
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
HTKEENGLAL
56
PsiBlast_CBE
94.43
99%
-121
- C2 -
1W12
1
?
U:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
2
PsiBlast_PDB
94.25
99%
-119
- C2 -
1SC8
1
?
U:
[16-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
59
PsiBlast_CBE
94.22
99%
-121
- C2 -
1W0Z
1
?
U:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
76
HHSearch
94.15
100%
-122
- C2 -
3MHW
1
?
U:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
-
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
11
PsiBlast_PDB
93.92
99%
-118
- C2 -
2R2W
1
?
U:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
40
PsiBlast_CBE
93.91
99%
-119
- C2 -
3QN7
2
UROK_HUMAN
A:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
--------
55
PsiBlast_CBE
93.90
99%
-119
- C2 -
1W13
1
?
U:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
7
PsiBlast_PDB
93.90
99%
-119
- C2 -
1EJN
1
UROK_HUMAN
A:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
3
PsiBlast_PDB
93.87
99%
-122
- C2 -
1VJ9
1
?
U:
[16-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
20
PsiBlast_PDB
93.82
99%
-123
- C2 -
1GJA
4
?
B:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
--------
54
PsiBlast_CBE
93.74
99%
-119
- C2 -
1W14
1
?
U:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
4
PsiBlast_PDB
93.73
99%
-119
- C2 -
1VJA
1
?
U:
[16-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
58
PsiBlast_CBE
93.71
99%
-120
- C2 -
1W10
1
?
U:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
9
PsiBlast_PDB
93.69
99%
-121
- C2 -
1F5L
1
UROK_HUMAN
A:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
--------
57
PsiBlast_CBE
93.68
99%
-120
- C2 -
1W11
1
?
U:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
41
PsiBlast_CBE
93.63
99%
-119
- C2 -
3OY6
1
UROK_HUMAN
U:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
33
PsiBlast_CBE
93.63
99%
-126
- C2 -
1C5Z
2
?
B:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
--------
10
PsiBlast_PDB
93.37
99%
-119
- C2 -
1F92
1
?
A:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
44
PsiBlast_CBE
93.36
99%
-117
- C2 -
3M61
1
?
U:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
52
PsiBlast_CBE
93.32
98%
-120
- C2 -
2O8U
4
?
A:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
-----
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
--
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
A
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
--------
26
PsiBlast_CBE
93.28
100%
-121
- C2 -
3IG6
3
?
D:
[1-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
---
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
-------
8
PsiBlast_PDB
93.22
99%
-120
- C2 -
1F5K
1
?
U:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
5
PsiBlast_PDB
93.17
100%
-121
- C2 -
3IG6
3
?
B:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
--------
47
PsiBlast_CBE
93.15
99%
-120
- C2 -
3KGP
1
?
A:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
----
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
--
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
--------
37
PsiBlast_CBE
92.86
98%
-122
- C2 -
1O5C
4
?
B:
[1-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
A
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
-------
31
PsiBlast_CBE
92.85
99%
-121
- C2 -
1GJB
4
?
B:
[1-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
-------
34
PsiBlast_CBE
92.73
99%
-122
- C2 -
1C5Y
2
?
B:
[1-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
E
-----
51
PsiBlast_CBE
92.66
98%
-119
- C2 -
2O8W
2
UROK_HUMAN
A:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
A
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
--------
32
PsiBlast_CBE
92.53
99%
-123
- C2 -
1GJ9
4
?
B:
[1-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
-------
61
PsiBlast_CBE
92.38
99%
-120
- C2 -
3MWI
1
?
U:
[1-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
-------
36
PsiBlast_CBE
92.31
99%
-121
- C2 -
1C5W
2
?
B:
[1-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
E
-----
29
PsiBlast_CBE
92.31
99%
-121
- C2 -
1GJD
4
?
B:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
--------
35
PsiBlast_CBE
92.18
99%
-122
- C2 -
1C5X
2
?
B:
[1-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
E
-----
45
PsiBlast_CBE
92.14
99%
-122
- C2 -
3KID
1
?
U:
[1-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
-----
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
---
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
-------
19
PsiBlast_PDB
92.13
99%
-120
- C2 -
1GJ8
4
?
B:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
--------
49
PsiBlast_CBE
92.06
99%
-119
- C2 -
2NWN
1
UROK_HUMAN
A:
[1-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
----
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
--
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
-------
38
PsiBlast_CBE
92.06
98%
-122
- C2 -
1O5B
5
?
B:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
A
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
--------
39
PsiBlast_CBE
91.90
98%
-120
- C2 -
1O5A
3
?
B:
[1-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
A
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
-------
46
PsiBlast_CBE
91.81
99%
-118
- C2 -
3KHV
2
UROK_HUMAN
A:
[1-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
----
S
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
---
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
-------
18
PsiBlast_PDB
91.81
99%
-122
- C2 -
1GJ7
4
?
B:
[1-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
-------
27
PsiBlast_CBE
91.64
99%
-118
- C2 -
1LMW
3
?
D:
[1-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
E
-----
30
PsiBlast_CBE
91.23
99%
-120
- C2 -
1GJC
4
?
B:
[1-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
-------
28
PsiBlast_CBE
90.86
99%
-120
- C2 -
1O3P
4
?
B:
[1-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
-------
6
PsiBlast_PDB
90.50
99%
-114
- C2 -
1LMW
2
?
B:
[1-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
-
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
E
-----
89
HHSearch
71.71
37%
-109
* C2 *
2OQ5
1
TM11E_HUMAN
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
E
V
E
E
G
E
W
P
W
Q
A
S
L
Q
W
D
G
-----
S
H
R
C
G
A
T
L
I
N
A
T
W
L
V
S
A
A
H
C
F
T
T
Y
K
N
P
A
R
W
T
A
S
F
G
V
T
I
----
K
P
S
K
M
K
R
G
L
R
R
I
I
V
H
E
K
Y
K
H
P
S
--
H
D
Y
D
I
S
L
A
E
L
S
S
P
----
V
P
Y
T
N
A
V
H
R
V
C
L
P
D
A
S
Y
---
E
F
Q
P
G
D
V
M
F
V
T
G
F
G
A
L
K
N
D
G
-
Y
S
Q
N
H
L
R
Q
A
Q
V
T
L
I
D
A
T
T
C
N
E
P
Q
A
Y
---
N
D
A
I
T
P
R
M
L
C
A
G
S
L
E
G
K
T
D
A
C
Q
G
D
S
G
G
P
L
V
S
S
D
A
R
D
I
W
Y
L
A
G
I
V
S
W
G
--
D
E
C
A
K
P
N
K
P
G
V
Y
T
R
V
T
A
L
R
D
W
I
T
S
K
T
G
-------
87
HHSearch
67.39
33%
-101
- C2 -
3BG8
1
A:
[1-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
--
T
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
S
E
I
K
E
D
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
T
D
S
Q
R
P
I
S
L
P
S
K
G
E
---
R
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
R
D
-
K
I
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
-
Y
R
---
G
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
-
N
E
V
W
H
L
V
G
I
T
S
W
G
--
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
------
99
HHSearch
67.17
35%
-106
- C2 -
1BRU
1
CEL2A_PIG
P:
[1-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
R
P
N
S
W
P
W
Q
V
S
L
Q
Y
D
S
S
-
G
Q
W
R
H
T
C
G
G
T
L
V
D
Q
S
W
V
L
T
A
A
H
C
I
S
S
---
S
R
T
Y
R
V
V
L
G
R
H
S
L
S
T
N
E
P
G
S
L
A
V
K
V
S
K
L
V
V
H
Q
D
W
N
S
N
Q
L
S
N
G
N
D
I
A
L
L
K
L
A
S
P
----
V
S
L
T
D
K
I
Q
L
G
C
L
P
A
A
G
T
---
I
L
P
N
N
Y
V
C
Y
V
T
G
W
G
R
L
Q
T
N
G
-
A
S
P
D
I
L
Q
Q
G
Q
L
L
V
V
D
Y
A
T
C
S
K
P
G
W
W
---
G
S
T
V
K
T
N
M
I
C
A
G
G
D
-
G
I
I
S
S
C
N
G
D
S
G
G
P
L
N
C
Q
G
A
N
G
Q
W
Q
V
H
G
I
V
S
F
G
SS
L
G
C
N
Y
Y
H
K
P
S
V
F
T
R
V
S
N
Y
I
D
W
I
N
S
V
I
A
N
------
97
HHSearch
66.19
31%
-93
- C2 -
4JZE
4
?
H:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
K
V
C
P
K
G
E
C
P
W
Q
V
L
L
L
V
N
-----
G
A
Q
L
C
G
G
T
L
I
N
T
I
W
V
V
S
A
A
H
C
F
D
K
I
K
N
W
R
N
L
I
A
V
L
G
E
H
D
L
S
E
H
D
G
D
E
Q
S
R
R
V
A
Q
V
I
I
P
S
T
Y
V
P
G
T
--
T
N
H
D
I
A
L
L
R
L
H
Q
P
V
----
V
L
T
D
H
V
V
P
L
C
L
P
E
R
T
F
SER
T
L
A
F
V
R
F
S
L
V
S
G
W
G
Q
L
L
D
R
G
-
A
T
A
L
E
L
M
V
L
N
V
P
R
L
M
T
Q
D
C
L
Q
Q
S
R
K
VGD
S
P
N
I
T
E
Y
M
F
C
A
G
Y
S
D
G
S
K
D
S
C
K
G
D
S
G
G
P
H
A
T
H
Y
-
R
G
T
W
Y
L
T
G
I
V
S
W
G
--
Q
G
C
A
T
V
G
H
F
G
V
Y
T
R
V
S
Q
Y
I
E
W
L
Q
K
L
M
R
S
E
P
R
P
--