@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : 5HT4R_HUMAN: (2016-01-08 )
MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80.-.......90........100.......110.......120.......130---.......140.......150.......160.......170.......180....--..--.--190........200........210.......220.......230------------------------------------------------------------------------------------------------------------..----------------------------.-----------------------.---------------------------.---------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------.----------------------------------------------------------------.---------------------------------------------------------------------240------------------.-.-----------.--------------.-------------.....250.--------------------------......260.......270.......280.....--..290.......--300.......310.......320.......330.......340.......350.......360.......370.......380......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDKLDANVSSEEGF
G
S
V
E
K
V
V
L
L
T
F
L
S
T
V
I
L
M
A
I
L
G
N
L
L
V
M
V
A
V
C
W
D
R
Q
L
R
K
IKT
N
Y
F
I
V
S
L
A
F
A
D
L
L
V
S
V
L
VMP
F
G
A
I
E
L
V
-
Q
D
I
W
I
Y
G
E
V
F
C
L
V
R
T
S
L
D
V
L
L
T
T
A
S
I
F
H
L
C
C
I
S
L
D
R
Y
Y
A
I
CC
Q
P
L
V
YRNK---MT
P
L
R
I
A
L
M
LGG
C
W
V
I
P
T
F
I
S
F
L
P
I
M
QGWNNI
G
I
I
D
L
I
E
K
RKFNQNSN
S
T
Y
C
V
F
--
M
V--N--K
P
-
Y
A
I
T
C
S
V
V
A
-
F
Y
I
P
F
L
L
M
V
L
A
Y
Y
R
I
Y
V
T
A
K
E
H
A
H
Q
I
Q
M
L
Q
R-------------------------------------------------------------------------------------------------------------AG----------------------------A-----------------------S---------------------------S---------------------------------------------------------------------------------------E-------------------------------------------------------------------------------------------S----------------------------------------------------------------R---------------------------------------------------------------------P--------------------Q-S-----------A--------------D-------------QH
S
T
H
R
M
R
T
--------------------------
E
T
K
A
A
K
T
L
C
I
I
M
G
C
F
C
L
C
W
A
P
F
F
V
T
N
I
V
D
P
F
IDY--TV
P
G
Q
V
W
T
A
F
L
W
--
L
G
Y
I
NSG
L
N
P
F
L
Y
A
F
L
N
K
S
F
R
R
A
F
L
I
I
L
C
CDDERYRRPSILGQTVPC
S
T
T
TING
S
T
H
V
L
R
D
A
V
E
CGGQWESQCHPPATS
P
L
VAAQPSDT
85
HHSearch
95.75
37%
-145
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
-
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
-
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
-
N
C
----
Y
A
E
E
T
C
C
D
F
--
F
T
--
N
--
Q
A
-
Y
A
I
A
S
S
I
V
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
-------------------------------------------------------------------------------------------------------------
D
E
----------------------------
G
-----------------------
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
---------------------------------------------------------------------------------------
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
----------------------------------------------------------------
K
S
R
W
------------------------------------------------------------------
Y
--------------------
N
-
Q
-----------
T
P
N
R
A
K
R
V
I
T
T
F
R
TG
T
-------------
W
D
A
Y
K
F
C
L
K
--------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
--
L
I
R
K
E
V
Y
I
L
L
N
W
--
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------------------------------------
75
Fugue
95.60
37%
-153
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
-
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
-
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
-----
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
--
F
T
--
N
--
Q
A
-
Y
A
I
A
S
S
I
V
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
----------------------------
L
-----------------------
Q
---------------------------
Q
---------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------
R
----------------------------------------------------------------
W
---------------------------------------------------------------------
D
--------------------
E
-
A
-----------
A
--------------
V
-------------
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
--
L
I
R
K
E
V
Y
I
L
L
N
W
--
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------------------------------------
90
HHSearch
92.69
37%
-154
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
-
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
-
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
-
G
F
N
T
T
G
--------------
D
P
T
V
C
S
I
--
S
---
N
--
P
D
-
F
V
I
Y
S
S
V
V
S
-
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
-------------------------------------------------------------------------------------------------------------
R
I
----------------------------
D
E
GLRL
K
I
Y
K
D
-------------
T
---------------------------
E
---------------------------------------------------------------------------------------
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT-------------------------------------------------------
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
-------------------------------------------------------------
A
K
S
R
W
Y
---------------
N
-
Q
-----------
T
P
N
R
-----------
A
K
R
V
I
T
T
F
R
T
GT--
W
D
A
Y
G
V
P
L
R
--------------------------
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C-
H
V
S
P
E
L
Y
S
A
T
T
W
--
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-----------------------------------------------------------
84
HHSearch
91.93
30%
-148
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[21-457]
----------------
F
E
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
-
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
-
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
-
F
W
Q
F
I
V
G
V
R
---------
T
V
E
D
G
E
C
Y
I
--
Q
F
FS
N
--
A
A
-
V
T
F
G
T
A
I
A
A
-
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
-------------------------------------------------------------------------------------------------------------
D
E
----------------------------
G
LRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTK
S
PS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
---
D
---------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------
A
----------------------------------------------------------------
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
----------------
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
-----------
T
P
N
R
A
K
R
V
I
T
T
F
R
TG
T
-------------
W
D
A
Y
P
P
P
S
R
--------------------------
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
--
C
I
P
N
T
V
W
T
I
G
Y
W
--
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
------------------------------------------------------------
88
HHSearch
90.52
32%
-149
- C4 -
3EML
13
ENLYS_BPT4
A:
[21-471]
------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
-
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
---
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
-
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
--
E
D
--
V
VP
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
-------------------------------------------------------------------------------------------------------------
D
E
----------------------------
G
-----------------------
L
RL
K
I
Y
K
D
TEGYYTIGIGHLLT------
K
SPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
-------------------------------------------------------------------------------------------
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
-----------------------------------------------
T
---------------------------------------------------------------------
P
--------------------
N
-
R
A
K
R
V
I
T
T
F
R
TG
T
--------------
W
-------------
D
A
Y
R
S
T
L
Q
K
--------------------------
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
CS
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
------------------------------------------------------
86
HHSearch
90.28
33%
-158
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
-------------------
M
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
-
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
-
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
-
P
I
L
-
G
W
N
H
---------------
R
R
E
D
K
C
E
T
--
D
F
--
Y
DV
T
W
-
F
K
V
M
T
A
I
I
N
-
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
-------------------------------------------------------------------------------------------------------------
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
-----------------------
A
---------------------------
A
K
S
E
L
D
K
A
I
-------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------
R
----------------------------------------------------------------
N
TNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
---
Q
-
T
-----------
P
--------------
N
R
A
K
R
V
I
T
T
F
R
TGT
W
D
A
Y
L
H
M
N
R
--------------------------
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
--
C
C
N
E
H
L
H
M
F
T
I
W
--
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
-----------------------------------------------------------
23
PsiBlast_CBE
88.29
40%
-154
- C4 -
3ZPR
12
ADRB1_MELGA
B:
[17-299]
------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
-----
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
--
V
T
--
N
--
R
A
-
Y
A
I
A
S
S
I
I
S
-
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
I
R
K
I
D
R
-------------------------------------------------------------------------------------------------------------
A
S
----------------------------
K
-----------------------
R
---------------------------
K
---------------------------------------------------------------------------------------
T
-------------------------------------------------------------------------------------------
S
----------------------------------------------------------------
R
---------------------------------------------------------------------
V
--------------------
M
-
L
-----------
M
--------------
R
-------------
E
H
-----------------------------------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
--
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
-------------------------------------------------------------
4
PsiBlast_PDB
88.21
40%
-163
- C4 -
2Y03
9
ADRB1_MELGA
A:
[17-300]
------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
-----
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
--
V
T
--
N
--
R
A
-
Y
A
I
A
S
S
I
I
S
-
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----------------------------------------------------------------
R
---------------------------------------------------------------------
V
--------------------
M
-
L
-----------
M
--------------
R
-------------
E
H
-----------------------------------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
--
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------------------------------
7
PsiBlast_PDB
88.20
40%
-159
- C4 -
3ZPQ
11
ADRB1_MELGA
A:
[17-300]
------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
-----
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
--
V
T
--
N
--
R
A
-
Y
A
I
A
S
S
I
I
S
-
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----------------------------------------------------------------
R
---------------------------------------------------------------------
V
--------------------
M
-
L
-----------
M
--------------
R
-------------
E
H
-----------------------------------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
--
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------------------------------
1
PsiBlast_PDB
88.14
40%
-159
- C4 -
2Y00
13
ADRB1_MELGA
A:
[17-300]
------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
-----
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
--
V
T
--
N
--
R
A
-
Y
A
I
A
S
S
I
I
S
-
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----------------------------------------------------------------
R
---------------------------------------------------------------------
V
--------------------
M
-
L
-----------
M
--------------
R
-------------
E
H
-----------------------------------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
--
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------------------------------
11
PsiBlast_PDB
87.98
40%
-149
- C4 -
2YCW
7
ADRB1_MELGA
A:
[17-299]
------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
-----
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
--
V
T
--
N
--
R
A
-
Y
A
I
A
S
S
I
I
S
-
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
I
R
K
I
D
R
-------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
S
---------------------------
K
---------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------
K
----------------------------------------------------------------
R
---------------------------------------------------------------------
V
--------------------
M
-
L
-----------
M
--------------
R
-------------
E
H
-----------------------------------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
--
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-----------------------------------------------------------
36
PsiBlast_CBE
87.87
40%
-162
- C4 -
2VT4
9
ADRB1_MELGA
B:
[17-299]
------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
-----
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
--
V
T
--
N
--
R
A
-
Y
A
I
A
S
S
I
I
S
-
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
-----------------------------------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
--
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-----------------------------------------------------------
21
PsiBlast_CBE
87.79
40%
-153
- C4 -
4AMJ
11
ADRB1_MELGA
B:
[17-300]
------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
-----
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
--
V
T
--
N
--
R
A
-
Y
A
I
A
S
S
I
I
S
-
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
I
R
K
I
D
R
-------------------------------------------------------------------------------------------------------------
A
S
----------------------------
K
-----------------------
R
---------------------------
K
---------------------------------------------------------------------------------------
T
-------------------------------------------------------------------------------------------
S
----------------------------------------------------------------
R
---------------------------------------------------------------------
V
--------------------
M
-
L
-----------
M
--------------
R
-------------
E
H
-----------------------------------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
--
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------------------------------
33
PsiBlast_CBE
87.77
40%
-152
- C4 -
2YCW
6
ADRB1_MELGA
B:
[17-299]
------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
-----
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
--
V
T
--
N
--
R
A
-
Y
A
I
A
S
S
I
I
S
-
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
I
R
K
I
D
R
-------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
S
---------------------------
K
---------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------
K
----------------------------------------------------------------
R
---------------------------------------------------------------------
V
--------------------
M
-
L
-----------
M
--------------
R
-------------
E
H
-----------------------------------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
--
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-----------------------------------------------------------
8
PsiBlast_PDB
87.74
40%
-161
- C4 -
3ZPR
11
ADRB1_MELGA
A:
[17-299]
------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
-----
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
--
V
T
--
N
--
R
A
-
Y
A
I
A
S
S
I
I
S
-
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
L
-----------
M
--------------
R
-------------
E
H
-----------------------------------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
--
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
-------------------------------------------------------------
26
PsiBlast_CBE
87.70
40%
-153
- C4 -
2Y03
8
ADRB1_MELGA
B:
[17-300]
------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
-----
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
--
V
T
--
N
--
R
A
-
Y
A
I
A
S
S
I
I
S
-
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
I
R
K
I
D
R
-------------------------------------------------------------------------------------------------------------
A
S
----------------------------
K
-----------------------
R
---------------------------
K
---------------------------------------------------------------------------------------
T
-------------------------------------------------------------------------------------------
S
----------------------------------------------------------------
R
---------------------------------------------------------------------
V
--------------------
M
-
L
-----------
M
--------------
R
-------------
E
H
-----------------------------------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
--
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------------------------------
24
PsiBlast_CBE
87.70
40%
-153
- C4 -
3ZPQ
13
ADRB1_MELGA
B:
[17-300]
------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
-----
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
--
V
T
--
N
--
R
A
-
Y
A
I
A
S
S
I
I
S
-
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
I
R
K
I
D
R
-------------------------------------------------------------------------------------------------------------
A
S
----------------------------
K
-----------------------
R
---------------------------
K
---------------------------------------------------------------------------------------
T
-------------------------------------------------------------------------------------------
S
----------------------------------------------------------------
R
---------------------------------------------------------------------
V
--------------------
M
-
L
-----------
M
--------------
R
-------------
E
H
-----------------------------------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
--
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------------------------------
28
PsiBlast_CBE
87.57
40%
-155
- C4 -
2Y01
12
ADRB1_MELGA
B:
[17-300]
------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
-----
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
--
V
T
--
N
--
R
A
-
Y
A
I
A
S
S
I
I
S
-
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
I
R
K
I
D
R
-------------------------------------------------------------------------------------------------------------
A
S
----------------------------
K
-----------------------
R
---------------------------
K
---------------------------------------------------------------------------------------
T
-------------------------------------------------------------------------------------------
S
----------------------------------------------------------------
R
---------------------------------------------------------------------
V
--------------------
M
-
L
-----------
M
--------------
R
-------------
E
H
-----------------------------------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
--
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------------------------------
2
PsiBlast_PDB
87.53
40%
-161
- C4 -
2Y01
12
ADRB1_MELGA
A:
[17-300]
------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
-----
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
--
V
T
--
N
--
R
A
-
Y
A
I
A
S
S
I
I
S
-
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----------------------------------------------------------------
R
---------------------------------------------------------------------
V
--------------------
M
-
L
-----------
M
--------------
R
-------------
E
H
-----------------------------------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
--
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------------------------------
13
PsiBlast_PDB
87.41
40%
-156
- C4 -
2YCZ
2
ADRB1_MELGA
A:
[17-299]
------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
-----
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
--
V
T
--
N
--
R
A
-
Y
A
I
A
S
S
I
I
S
-
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
I
R
K
I
D
R
-------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
S
---------------------------
K
---------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------
K
----------------------------------------------------------------
R
---------------------------------------------------------------------
V
--------------------
M
-
L
-----------
M
--------------
R
-------------
E
H
-----------------------------------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
--
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-----------------------------------------------------------
9
PsiBlast_PDB
87.28
39%
-148
- C4 -
4BVN
11
ADRB1_MELGA
A:
[17-300]
------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
-----
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
--
V
T
--
N
--
R
A
-
Y
A
I
A
S
S
I
I
S
-
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
I
R
-----------------------------------------------------------------------------------------------------------------------------------------------
K
-----------------------
R
---------------------------
K
---------------------------------------------------------------------------------------
T
-------------------------------------------------------------------------------------------
S
----------------------------------------------------------------
R
---------------------------------------------------------------------
V
--------------------
M
-
L
-----------
M
--------------
R
-------------
E
H
-----------------------------------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
K
W
L
F
V
A
F
N
W
--
L
G
Y
A
N
S
A
M
N
P
I
I
L
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------------------------------
14
PsiBlast_PDB
86.96
40%
-152
- C4 -
2YCY
6
ADRB1_MELGA
A:
[17-299]
------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
-----
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
--
V
T
--
N
--
R
A
-
Y
A
I
A
S
S
I
I
S
-
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
I
R
--
D
R
-------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
S
---------------------------
K
---------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------
K
----------------------------------------------------------------
R
---------------------------------------------------------------------
V
--------------------
M
-
L
-----------
M
--------------
R
-------------
E
H
-----------------------------------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
--
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-----------------------------------------------------------
10
PsiBlast_PDB
86.91
40%
-161
- C4 -
2VT4
8
ADRB1_MELGA
A:
[17-298]
------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
-----
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
--
V
T
--
N
--
R
A
-
Y
A
I
A
S
S
I
I
S
-
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
-----------------------------------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
--
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------------------------------
54
PsiBlast_CBE
83.73
32%
-164
- C4 -
3VG9
8
?
A:
[8-309]
--------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
-
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
--
I
-
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
-
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
ED
V
V
--
P
--
M
N
-
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------
S
----------------------------------------------------------------
Q
---------------------------------------------------------------------
P
--------------------
L
-
P
-----------
G
--------------
E
-------------
R
-
A
R
S
T
L
Q
K
--------------------------
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
-------------------------------------------------------