@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O2AP1_HUMAN: (2016-01-11 )
MKNKTVLTEFILLGLTDVPELQVAVFTFLFLAYLLSILGNLTILILTLLDSHLQTPMYFFLRNFSFLEISFTNIFIPRVLISITTGNKSISFAGCFTQYFFAMFLGATEFYLLAAMSYDRYVAICKPLHYTTIMSSRICIQLIFCSWLGGLMAIIPTITLMSQQDFCASNRLNHYFCDYEPLLELSCSDTSLIEKVVFLVASVTLVVTLVLVILSYAFIIKTILKLPSAQQRTKAFSTCSSHMIVISLSYGSCMFMYINPSAKEGDTFNKGVALLITSVAPLLNPFIYTLRNQQVKQPFKDMVKKLLNL
Atome Classification :
(20 SA)
.........10......---------------.----------------.20........30........40........50........60........70....-....80........90........100.......110.......120.......130.......140.......150.......160.---......170.......180-.....-------.-------.190.......200.......210.......220-.....---------....230------------------.----..----......240.......250..--------.....260---...---.-------....270-....---.....280.......290.......300.......---------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKN
K
T
V
L
T
E
F
I
L
LGLTD---------------V----------------
P
E
L
Q
V
A
V
F
T
F
L
F
L
A
Y
L
L
S
I
LG
N
L
T
I
L
I
L
T
L
L
D
S
H
L
Q
T
P
M
Y
F
F
L
RNF
S
F
L
E
I
S
FT
N
I
F
-
I
P
R
V
L
I
S
I
TTGNK
S
I
S
F
A
G
C
F
T
Q
Y
F
F
A
M
F
L
G
A
T
E
F
Y
L
L
A
AMSYD
R
Y
V
A
I
CKP
L
H
Y
T
T
I
MSS
R
I
C
I
Q
L
I
F
C
S
W
L
G
G
L
M
A
I
I
P
T
I
TLMSQ---Q
D
F
C
A
SNRLNHYFCDY
E
P
L
-
L
E
LSC-------S-------
D
T
S
L
I
E
K
V
V
F
L
V
A
S
V
T
L
V
V
T
L
V
L
V
I
L
S
Y
A
F
I
I
---
K
T
I
L
K---------LPS
A
Q
--------------------
Q
----
R
T
----
K
A
F
STCSS
H
M
I
V
I
S
LSYG
S
C
M
--------
F
M
Y
INPS----AKE---G-------DTFNK---
G
V
A
L
---
L
I
T
S
V
A
P
L
L
N
P
F
I
Y
T
L
R
N
Q
Q
V
K
Q
P
F
K
D
M
V
K
K
L
LNL---------------------
8
PsiBlast_PDB
90.87
22%
-138
- C6 -
2YDO
3
?
A:
[18-305]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
A
I
S
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---
V
L
S
F
A
I
G
L
T
P
M
L
G
---
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
-
G
Q
V
A
C
LF-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S-------------------------------------T
L
Q
-
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
----
C
S
H
---
A
-------
P
L
W
L
M
---
Y
L
A
I
---
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
9
PsiBlast_PDB
89.99
22%
-142
- C6 -
2YDV
6
?
A:
[18-305]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
A
I
S
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---
V
L
S
F
A
I
G
L
T
P
M
L
G
---
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
-
G
Q
V
A
C
LF-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
ESQ-----------------------------------
S
T
L
Q
-
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
----
C
S
H
---
A
-------
P
L
W
L
M
---
Y
L
A
I
---
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
10
PsiBlast_PDB
89.53
22%
-137
- C6 -
4UG2
3
?
A:
[18-305]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
A
I
S
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---
V
L
S
F
A
I
G
L
T
P
M
L
G
---
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
-
G
Q
V
A
C
LF-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
-----------------------------------
A
----
R
S
T
L
Q
-
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
----
C
S
H
---
A
-------
P
L
W
L
M
---
Y
L
A
I
---
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
11
PsiBlast_PDB
89.30
22%
-140
- C6 -
4UHR
1
AA2AR_HUMAN
A:
[18-305]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
A
I
S
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---
V
L
S
F
A
I
G
L
T
P
M
L
G
---
W
N
N
C
G
Q
P
K
E
G
K
A
---
G
C
G
E
-
G
Q
V
A
C
LF-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
QP---
L
P
G
E
R
--------------------
A
----
R
S
T
L
Q
-
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
----
C
-
H
---
A
-------
P
L
W
L
M
---
Y
L
A
I
---
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
6
PsiBlast_PDB
89.16
22%
-152
- C6 -
3VG9
8
?
A:
[18-304]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
---
L
S
F
A
I
G
L
T
P
M
L
G
---
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
-
G
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P---
L
P
G
E
R
--------------------
A
----
R
S
T
L
Q
-
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
----
C
S
H
---
A
-------
P
L
W
L
M
---
Y
L
A
I
---
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
7
PsiBlast_PDB
88.38
22%
-143
- C6 -
3VGA
1
AA2AR_HUMAN
A:
[18-304]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
---
L
S
F
A
I
G
L
T
P
M
L
G
---
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
-
G
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P---
L
P
G
E
R
--------------------
A
----
R
S
T
L
Q
-
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
----
C
S
H
---
A
-------
P
L
W
L
M
---
Y
L
A
I
---
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
----------------------
3
PsiBlast_PDB
86.86
21%
-141
- C6 -
3RFM
1
AA2AR_HUMAN
A:
[18-305]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---
V
L
S
F
A
I
G
L
T
P
M
L
G
---
W
N
N
C
G
Q
P
--------
G
C
G
E
-
G
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
---
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
--------------------
A
----
R
S
T
L
Q
-
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
----
C
S
H
---
A
-------
P
L
W
L
M
---
Y
L
A
I
---
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
53
Fugue
86.32
19%
-121
- C6 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
GVVRSPFEAPQYYLA
E
----------------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
------------------
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
K
E
---------
A
A
A
Q
Q
--------------------
Q
ESA
T
T
Q
----
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
--------
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
---
G
-------
S
D
F
G
P
---
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
LGDDEA
S
T
T
V
S
K
TETSQVAPA
52
Fugue
85.79
19%
-120
- C6 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
---------------
T
GVVRSPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
------------------
Y
I
P
E
G
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
K
E
---------
A
A
A
S
A
--------------------
T
----
T
Q
----
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
--------
L
P
Y
A
G
V
A
----
F
Y
I
---
F
T
H
QGSDF
G
P
I
F
M
---
T
I
P
A
---
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
STTVSKTETS
Q
V
A
P
A------
46
HHSearch
85.49
16%
-128
- C6 -
2Z73
5
OPSD_TODPA
A:
[32-332]
--------------------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
---
Y
T
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
-
S
-------------------
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
---
M
S
V
S
N
---------
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
----
E
M
----
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
--------
V
V
A
L
L
A
Q
----
F
G
P
LEW
V
-------
T
P
Y
A
A
---
Q
L
P
V
---
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
---------------------
4
PsiBlast_PDB
85.35
21%
-143
- C6 -
3UZA
1
AA2AR_HUMAN
A:
[18-305]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---
V
L
S
F
A
I
G
L
T
P
M
L
G
---
W
N
N
C
G
Q
P
--------
G
C
G
E
-
G
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
---
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
--------------------
A
----
R
S
T
L
Q
-
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
----
C
S
H
---
A
-------
P
L
W
L
M
---
Y
L
A
I
---
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
17
PsiBlast_PDB
85.25
19%
-129
- C6 -
3DQB
4
GNAT1_BOVIN (first)
A:
[43-315]
----------------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
-----------
T
P
-------
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
K
E
---------
A
A
A
Q
Q
--------------------
Q
----
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
--------
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
---
G
-------
S
D
F
G
P
I
F
M
T
I
P
A
---
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
16
PsiBlast_PDB
84.97
19%
-123
- C6 -
1F88
7
OPSD_BOVIN
A:
[43-315]
----------------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
-----------
T
P
-------
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
K
E
---------
A
A
A
----------------------------
S
ATTQ
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
--------
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
---
G
-------
S
D
F
G
P
IFM
T
I
P
A
---
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
---------------------
2
PsiBlast_PDB
84.97
21%
-142
- C6 -
3REY
1
AA2AR_HUMAN
A:
[18-305]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---
V
L
S
F
A
I
G
L
T
P
M
L
G
---
W
N
N
C
G
Q
P
--------
G
C
G
E
-
G
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
---
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
--------------------
A
----
R
S
T
L
Q
-
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
----
C
S
H
---
A
-------
P
L
W
L
M
---
Y
L
A
I
---
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
18
PsiBlast_PDB
84.88
19%
-128
- C6 -
3PQR
9
OPSD_BOVIN
A:
[43-315]
----------------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
-----------
T
P
-------
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
K
E
---------
A
A
A
Q
Q
--------------------
Q
----
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
--------
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
---
G
-------
S
D
F
G
P
I
F
M
T
I
P
A
---
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
15
PsiBlast_PDB
84.76
19%
-123
- C6 -
3C9L
13
OPSD_BOVIN
A:
[43-315]
----------------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
-----------
T
P
-------
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
K
E
---------
A
A
A
Q
Q
--------------------
Q
----
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
--------
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
---
G
-------
S
D
F
G
P
IFM
T
I
P
A
---
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
---------------------
1
PsiBlast_PDB
84.54
21%
-144
- C6 -
3PWH
1
?
A:
[18-305]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---
V
L
S
F
A
I
G
L
T
P
M
L
G
---
W
N
N
C
G
Q
P
--------
G
C
G
E
-
G
Q
V
A
C
LF-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
---
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
--------------------
A
----
R
S
T
L
Q
-
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
----
C
S
H
---
A
-------
P
L
W
L
M
---
Y
L
A
I
---
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
5
PsiBlast_PDB
84.35
21%
-143
- C6 -
3UZC
1
AA2AR_HUMAN
A:
[18-305]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---
V
L
S
F
A
I
G
L
T
P
M
L
G
---
W
N
N
C
G
Q
P
--------
G
C
G
E
-
G
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
---
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
--------------------
A
----
R
S
T
L
Q
-
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
----
C
S
H
---
A
-------
P
L
W
L
M
---
Y
L
A
I
---
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
19
PsiBlast_PDB
84.15
19%
-129
- C6 -
3PXO
4
OPSD_BOVIN
A:
[43-315]
----------------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
-----------
T
P
-------
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
K
E
---------
A
A
A
Q
Q
--------------------
Q
----
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
--------
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
---
G
-------
S
D
F
G
P
I
F
M
T
I
P
A
---
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
20
PsiBlast_PDB
83.66
19%
-128
- C6 -
4J4Q
8
GNAT1_BOVIN (first)
A:
[43-315]
----------------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
-----------
T
P
-------
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
K
E
---------
A
A
A
Q
Q
--------------------
Q
----
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
--------
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
---
G
-------
S
D
F
G
P
I
F
M
T
I
P
A
---
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------