@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O52B6_HUMAN: (2016-01-12 )
MAQVRALHKIMALFSANSIGAMNNSDTRIAGCFLTGIPGLEQLHIWLSIPFCIMYITALEGNGILICVILSQAILHEPMYIFLSMLASADVLLSTTTMPKALANLWLGYSLISFDGCLTQMFFIHFLFIHSAVLLAMAFDRYVAICSPLRYVTILTSKVIGKIVTAALSHSFIIMFPSIFLLEHLHYCQINIIAHTFCEHMGIAHLSCSDISINVWYGLAAALLSTGLDIMLITVSYIHILQAVFRLLSQDARSKALSTCGSHICVILLFYVPALFSVFAYRFGGRSVPCYVHILLASLYVVIPPMLNPVIYGVRTKPILEGAKQMFSNLAKGSK
Atome Classification :
(20 SA)
.........10........20........30......-..40.....---...50........60........70........80........90......-..100.----------......110....-...120.------......130..--......140.......150.......160.......170.......180........190.......200.......210.......220.......230.......240.......-----------------------------------------------------------------------------------------------------------------------------------------------------------------250.-----.------------.....260.......270.......280.......290.......300.......310.......320.......330...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
Q
V
R
A
L
H
K
I
M
A
L
F
SANSIGAMNNSD
T
R
I
A
G
C
F
LTGI-P
G
L
E
Q
L
H
I
W
---
L
SI
P
F
C
I
M
Y
I
T
ALEGN
G
I
L
I
C
V
I
L
S
Q
A
I
LH
E
P
M
Y
I
F
L
S
M
L
ASA
D
V
L
L
STTT-
M
P
K
A
L
A
----------
N
L
W
L
G
Y
S
L
I
S
F
D
G
-
C
L
T
Q
M
F
F
------
I
H
F
L
F
I
H
-
S
A
V
--
L
L
A
M
A
F
D
R
Y
V
A
I
CSP
L
R
Y
V
T
I
L
T
S
K
V
I
G
K
I
V
T
A
A
LSH
S
F
I
I
M
F
P
S
I
F
L
-
L
E
H
L
H
Y
C
Q
I
N
I
I
A
H
T
F
C
E
HMG
I
A
H
LSCS
D
I
S
I
N
V
W
Y
G
L
A
A
A
L
L
STGL
D
I
M
L
I
T
V
S
Y
I
H
I
L
Q
A
V
F
R
L
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
A
R
-----
S
------------
K
A
L
S
T
C
G
S
H
I
C
V
I
L
L
F
Y
V
P
A
L
F
S
V
F
A
Y
R
FGGRSV
P
C
Y
V
H
I
L
L
A
S
L
Y
V
VIPPM
L
N
P
V
IYGVR
T
K
P
I
L
E
G
A
K
Q
M
F
S
N
L
AKGSK
7
PsiBlast_PDB
89.15
20%
-169
- C3 -
2YCW
7
ADRB1_MELGA
A:
[8-299]
-----------------------------------------
Q
Q
W
E
A
G
---
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----------------
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-----
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
----
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
D
R
-----
A
SKRKR
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
-
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
------
9
PsiBlast_PDB
87.41
20%
-170
- C3 -
2YCZ
2
ADRB1_MELGA
A:
[9-299]
------------------------------------------
Q
W
E
A
G
---
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----------------
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-----
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
----
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
D
R
-----
A
SK
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
-
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
------
19
PsiBlast_PDB
86.87
20%
-175
- C3 -
3ZPR
11
ADRB1_MELGA
A:
[8-299]
-----------------------------------------
Q
Q
W
E
A
G
---
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----------------
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-----
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
----
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
L
M
R
E
H
------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
-
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
--------
35
HHSearch
86.81
19%
-154
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[39-477]
-------------------------------------------
W
V
V
G
---
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
----------
H
I
L
M
K
M
W
T
F
G
N
F
W
-
C
E
F
W
T
S
I
------
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
-----
Q
E
A
I
N
C
Y
A
E
E
----
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKF
C
L
K
E
-----
H
------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
-
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------
8
PsiBlast_PDB
86.34
20%
-172
- C3 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
------------------------------------------
Q
W
E
A
G
---
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----------------
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-----
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
----
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
D
R
-----
A
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
-
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
-----------
18
PsiBlast_PDB
86.19
20%
-172
- C3 -
3ZPQ
11
ADRB1_MELGA
A:
[8-300]
-----------------------------------------
Q
Q
W
E
A
G
---
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----------------
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-----
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
----
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
---
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
-
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------
32
HHSearch
85.96
19%
-159
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
---------------------------------------------
V
F
---
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
----------
Y
T
V
I
G
Y
W
P
L
G
P
V
V
-
C
D
L
W
L
A
L
------
D
Y
V
V
S
N
A
S
V
M
N
--
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
-
W
Q
F
I
V
G
V
R
--
T
V
E
D
G
E
C
Y
I
Q
F
F
---------
S
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP
P
S
R
E
-----
K
------------
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
-
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-------
36
HHSearch
85.95
19%
-154
* C3 *
2Z73
5
OPSD_TODPA
A:
[30-334]
----------------------------------------
P
D
A
V
Y
Y
S
---
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
----------
S
C
F
L
K
K
W
I
F
G
F
A
A
-
C
K
V
Y
G
F
I
------
G
G
I
F
G
F
M
S
I
M
T
--
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
-
W
G
A
Y
T
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
-----
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
---------------------------------------------------------------------------------------------------------------------------------------------
A
N
A
E
-----
M
------------
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
13
PsiBlast_PDB
85.81
20%
-171
- C3 -
2Y01
12
ADRB1_MELGA
A:
[8-300]
-----------------------------------------
Q
Q
W
E
A
G
---
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----------------
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-----
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
----
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
---
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
-
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------
12
PsiBlast_PDB
85.38
20%
-176
- C3 -
2Y00
13
ADRB1_MELGA
A:
[8-300]
-----------------------------------------
Q
Q
W
E
A
G
---
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----------------
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-----
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
----
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
---
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
-
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------
17
PsiBlast_PDB
85.16
20%
-172
- C3 -
4AMJ
12
ADRB1_MELGA
A:
[8-300]
-----------------------------------------
Q
Q
W
E
A
G
---
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----------------
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-----
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
----
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
---
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
-
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------
15
PsiBlast_PDB
85.14
20%
-176
- C3 -
2Y03
9
ADRB1_MELGA
A:
[8-300]
-----------------------------------------
Q
Q
W
E
A
G
---
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----------------
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-----
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
----
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
---
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
-
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------
2
PsiBlast_PDB
85.10
21%
-165
- C3 -
4QKX
2
ADRB2_HUMAN
A:
[135-447]
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
A
A
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
L
T
KTWTFG
N
F
W
C
E
F
-
W
T
S
I
D
V
L
C
V
T
A
S
I
----------------
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
----
W
I
V
S
G
L
T
S
F
L
-
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
FAL
K
E
H
------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
-
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------
14
PsiBlast_PDB
84.92
20%
-173
- C3 -
2Y02
13
ADRB1_MELGA
A:
[8-300]
-----------------------------------------
Q
Q
W
E
A
G
---
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----------------
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-----
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
----
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
---
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
-
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------
5
PsiBlast_PDB
84.62
21%
-166
- C3 -
4LDO
3
ENLYS_BPT4
A:
[135-447]
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
A
A
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
KTWTFG
N
F
W
C
E
F
-
W
T
S
I
D
V
L
C
V
T
A
S
I
----------------
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
----
W
I
V
S
G
L
T
S
F
L
-
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
FAL
K
E
H
------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
-
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------
10
PsiBlast_PDB
84.52
20%
-170
- C3 -
2YCY
6
ADRB1_MELGA
A:
[10-299]
-------------------------------------------
W
E
A
G
---
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----------------
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-----
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
----
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-----
A
SKR
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
-
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
------
34
HHSearch
84.37
18%
-152
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
----------------------------------------------
P
---
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
----------
Y
L
L
M
S
K
W
S
L
G
R
P
L
-
C
L
F
W
L
S
M
------
D
Y
V
A
S
T
A
S
I
F
S
--
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
--
W
N
H
--------
R
R
E
D
K
C
E
T
D
F
Y
D
---------
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH
M
N
R
E
-----
R
------------
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
C
-
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
------
6
PsiBlast_PDB
84.34
20%
-172
- C3 -
2VT4
8
ADRB1_MELGA
A:
[10-298]
-------------------------------------------
W
E
A
G
---
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----------------
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-----
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
----
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
----------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
-
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------
4
PsiBlast_PDB
83.87
21%
-167
- C3 -
4LDL
3
ADRB2_HUMAN (first)
A:
[135-447]
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
A
A
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
KTWTFG
N
F
W
C
E
F
-
W
T
S
I
D
V
L
C
V
T
A
S
I
----------------
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
----
W
I
V
S
G
L
T
S
F
L
-
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
FA
L
K
E
H
------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
-
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------
16
PsiBlast_PDB
83.45
20%
-172
- C3 -
2Y04
13
ADRB1_MELGA
A:
[8-300]
-----------------------------------------
Q
Q
W
E
A
G
---
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----------------
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-----
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
----
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
---
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
-
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------