@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O52E4_HUMAN: (2016-01-12 )
MPSINDTHFYPPFFLLLGIPGLDTLHIWISFPFCIVYLIAIVGNMTILFVIKTEHSLHQPMFYFLAMLSMIDLGLSTSTIPKMLGIFWFNLQEISFGGCLLQMFFIHMFTGMETVLLVVMAYDRFVAICNPLQYTMILTNKTISILASVVVGRNLVLVTPFVFLILRLPFCGHNIVPHTYCEHRGLAGLACAPIKINIIYGLMVISYIIVDVILIASSYVLILRAVFRLPSQDVRLKAFNTCGSHVCVMLCFYTPAFFSFMTHRFGQNIPHYIHILLANLYVVVPPALNPVIYGVRTKQIREQIVKIFVQKE
Atome Classification :
(20 SA)
.........10----------.........20........30........40........50........60........70..-----......-80........90......------..100.......110.......120.......130.......140........150.......160.......-----170..-.....180.......190--..----------..-....200.......-.210.......220-......---------.230----------.------------------------------------------------------------------------------------------------------------------------------------------------------------------...---....240--......----.---------250--.......260......--.--------270-----........280.......290.......300.......310-----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPSINDTHFY-----------
P
P
F
F
L
L
LGIPGL
D
T
L
H
I
W
I
S
F
P
F
C
I
V
Y
L
I
A
I
VGN
M
T
I
L
F
V
I
KTEHSLH
Q
P
M
F
Y
F
L
A
M
L
S
M
I
DL-----GLST
S
T
-
I
P
K
M
L
G
I
F
W
F
N
L
Q
EISF
G
------
G
C
L
L
Q
M
F
F
I
H
M
FT
G
M
E
T
V
L
L
V
V
M
A
Y
D
R
F
V
A
I
CNP
L
Q
Y
T
M
I
LTN-
K
T
I
S
I
L
A
S
V
V
VGR
N
L
V
L
V
T
P
F
V
F
L
I
L
RLP-----FCGHN-IVP
H
T
Y
C
EHRGLAGLAC---A
P
----------
I
K
-
I
N
I
I
Y
-
G
L
M
V
I
S
Y
I
-
I
V
D
V
I
L
I
A
S
S
Y
V
L
I
-
L
R
A
V
F
R---------LPS-----------Q------------------------------------------------------------------------------------------------------------------------------------------------------------------D
V
R
---
L
K
A
F
N
TC--
G
S
H
V
C
V
----
M
---------
L
C
F--Y
T
P
A
F
F
S
F
M
T
H
R
FGQN--
I
--------
P
H
------
Y
I
H
I
L
L
AN
L
Y
V
VVPPAL
N
P
V
IYGV
R
T
K
Q
I
R
E
Q
I
V
K
I
F
VQKE-----------------
6
PsiBlast_PDB
88.22
23%
-174
- C5 -
3VG9
8
?
A:
[16-302]
----------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
A
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
FCAA
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
G
Q
--------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
----------
V
P
-
M
N
Y
M
V
-
Y
F
N
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
-----------
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
--
K
S
L
A
I
I
----
V
G
L
F
A
-----
L
C
W
--
L
P
L
H
I
I
N
C
F
T
F
-
F
C
P
D
--
C
--------
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
----
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
-----------------
7
PsiBlast_PDB
87.88
23%
-172
- C5 -
3VGA
1
AA2AR_HUMAN
A:
[16-302]
----------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
A
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
FCAA
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
G
Q
--------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
----------
V
P
-
M
N
Y
M
V
-
Y
F
N
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
-----------
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
--
K
S
L
A
I
I
----
V
G
L
F
A
-----
L
C
W
--
L
P
L
H
I
I
N
C
F
T
F
-
F
C
P
D
--
C
--------
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
----
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
-----------------
5
PsiBlast_PDB
87.16
23%
-175
- C5 -
3UZC
1
AA2AR_HUMAN
A:
[16-302]
----------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
G
Q
P
---------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
----------
V
P
-
M
N
Y
M
V
-
Y
F
N
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
-----------
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
--
K
S
A
A
I
I
A
G
L
F
A
---------
L
C
W
--
L
P
L
H
I
I
N
C
F
T
F
-
F
C
P
D
--
C
--------
S
H
AP
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
----
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------
2
PsiBlast_PDB
87.12
23%
-174
- C5 -
3REY
1
AA2AR_HUMAN
A:
[16-302]
----------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
G
Q
P
---------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
----------
V
P
-
M
N
Y
M
V
-
Y
F
N
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
-----------
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
--
K
S
A
A
I
I
A
G
L
F
A
---------
L
C
W
--
L
P
L
H
I
I
N
C
F
T
F
-
F
C
P
D
--
C
--------
S
H
AP
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
----
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------
4
PsiBlast_PDB
86.95
23%
-177
- C5 -
3UZA
1
AA2AR_HUMAN
A:
[16-302]
----------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
G
Q
P
---------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
----------
V
P
-
M
N
Y
M
V
-
Y
F
N
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
-----------
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
--
K
S
A
A
I
I
A
G
L
F
A
---------
L
C
W
--
L
P
L
H
I
I
N
C
F
T
F
-
F
C
P
D
--
C
--------
S
H
AP
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
----
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------
3
PsiBlast_PDB
86.50
23%
-176
- C5 -
3RFM
1
AA2AR_HUMAN
A:
[16-302]
----------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
G
Q
P
---------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
----------
V
P
-
M
N
Y
M
V
-
Y
F
N
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
-----------
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
--
K
S
A
A
I
I
A
G
L
F
A
---------
L
C
W
--
L
P
L
H
I
I
N
C
F
T
F
-
F
C
P
D
--
C
--------
S
H
AP
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
----
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------
1
PsiBlast_PDB
85.83
23%
-174
- C5 -
3PWH
1
?
A:
[16-302]
----------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
G
Q
P
---------
G
C
G
E
G
Q
V
A
C
LFE
D
V
----------
V
P
-
M
N
Y
M
V
-
Y
F
N
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
-----------
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
--
K
S
A
A
I
I
A
G
L
F
A
---------
L
C
W
--
L
P
L
H
I
I
N
C
F
T
F
-
F
C
P
D
--
C
--------
S
H
AP
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
----
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------
25
HHSearch
85.70
17%
-159
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[41-477]
-------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
-----
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
------
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
-
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
-----
T
H
-----
Q
E
A
I
N
C
Y
A
E
----
E
T
C
---
C
D
----------
F
F
-
T
N
Q
A
Y
-
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-
F
Q
E
A
K
R
---------
Q
L
N
-----------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC-
L
K
E
---
H
K
A
L
K
T
L
--
G
I
I
M
G
T
----
F
---------
T
L
C
--
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
--
L
--------
I
R
------
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
26
HHSearch
82.99
18%
-169
- C5 -
3EML
13
ENLYS_BPT4
A:
[22-468]
-------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
--
G
F
C
A
A
C
H
------
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
-
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
-----
Q
--------
S
Q
G
C
G
E
G
Q
V
---
A
C
---
L
F
----------
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
L
A
A
R
R
---------
Q
L
N
-----------
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
Q
K
E
---
V
H
A
A
K
S
L
--
A
I
I
V
G
L
----
F
---------
A
L
C
--
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
CS
H
--------
A
P
------
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
-----------------
17
PsiBlast_PDB
81.94
23%
-153
- C5 -
1F88
7
OPSD_BOVIN
A:
[55-318]
------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
-----------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
-------------------------
V
I
Y
---
M
F
V
V
H
F
-
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-
V
F
T
V
K
E
---------
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
T
T
Q
K
A
--
E
K
E
V
T
R
----
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
--
G
--------
P
--------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
-----------------
24
HHSearch
81.66
17%
-154
- C5 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
---------------------------------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
-----
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
M
S
K
W
S
L
G
R
P
------
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
R
T
K
-
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
-
W
N
H
--------------
R
R
E
D
K
C
E
T
D
F
Y
-----------------------
D
V
T
W
F
-
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
-
Y
K
A
V
R
Q
---------
H
C
N
-----------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM-
N
R
E
---
R
K
A
A
K
Q
L
--
G
F
I
M
A
A
----
F
---------
I
L
C
--
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
--
C
--------
C
N
------
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
-------------------
41
Fugue
80.60
19%
-150
- C5 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
VPFSNKTGVVR
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
-----
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-------------
V
G
W
S
R
-
Y
I
P
E
------
G
M
-
Q
C
S
C
---
G
I
DYYTPHEETN
N
E
-
S
F
V
I
Y
-
M
F
V
V
H
F
I
I
-
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
---------
S
A
T
-----------
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
---
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
----
L
---------
I
C
W
--
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
--------
F
G
------
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
NPSTTVSKTETS
Q
V
A
P
A
18
PsiBlast_PDB
79.00
23%
-161
- C5 -
3DQB
4
GNAT1_BOVIN (first)
A:
[55-318]
------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
-----------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
EGMQC
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
-------------------------
V
I
Y
---
M
F
V
V
H
F
-
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-
V
F
T
V
K
E
---------
A
A
A
-----------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
E
---
S
A
T
T
Q
K
A
--
E
K
E
V
T
R
----
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
--
G
--------
P
--------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
-----------------
16
PsiBlast_PDB
78.99
23%
-155
- C5 -
3C9L
12
OPSD_BOVIN
A:
[55-318]
------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
-----------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
-------------------------
V
I
Y
---
M
F
V
V
H
F
-
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-
V
F
T
V
K
E
---------
A
A
A
-----------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
E
---
S
A
T
T
Q
K
A
--
E
K
E
V
T
R
----
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
--
G
--------
P
--------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
-----------------
30
HHSearch
78.43
15%
-155
- C5 -
2KS9
1
NK1R_HUMAN
A:
[34-323]
--------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
-----
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
------
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
-
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
T
-----------
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
------
N
----------
K
I
-
Y
E
K
V
Y
-
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
-
G
I
T
L
W
A
---------
S
E
I
PGDSSDRYH
E
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
---
R
K
V
V
K
M
M
--
I
V
V
V
C
T
----
F
---------
A
I
C
--
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
D
--
L
YL------
K
K
FI----
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
-----------------
19
PsiBlast_PDB
78.07
23%
-160
- C5 -
3PQR
8
OPSD_BOVIN
A:
[55-318]
------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
FG
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
-----------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
EGMQC
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
-------------------------
V
I
Y
---
M
F
V
V
H
F
-
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-
V
F
T
V
K
E
---------
A
A
A
-----------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
E
---
S
A
T
T
Q
K
A
--
E
K
E
V
T
R
----
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
--
G
--------
P
--------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
-----------------
20
PsiBlast_PDB
77.50
23%
-158
- C5 -
3PXO
4
OPSD_BOVIN
A:
[55-318]
------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
-----------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
EGMQC
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
-------------------------
V
I
Y
---
M
F
V
V
H
F
-
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-
V
F
T
V
K
E
---------
A
A
A
-----------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
E
---
S
A
T
T
Q
K
A
--
E
K
E
V
T
R
----
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
--
G
--------
P
--------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
-----------------
15
PsiBlast_PDB
77.48
23%
-159
- C5 -
3CAP
4
OPSD_BOVIN
A:
[55-318]
------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
-----------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
EGMQC
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
-------------------------
V
I
Y
---
M
F
V
V
H
F
-
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-
V
F
T
V
K
E
---------
A
A
A
-----------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
E
---
S
A
T
T
Q
K
A
--
E
K
E
V
T
R
----
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
--
G
--------
P
--------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
-----------------
35
HHSearch
77.01
17%
-157
* C5 *
2Z73
5
OPSD_TODPA
A:
[33-332]
-----------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
-----
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
------
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
-
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
-----
L
-----
E
G
V
L
C
N
C
S
F
D
Y
I
S
--------
R
----------
D
S
-
T
T
R
S
N
-
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
-
V
M
S
V
S
N
---------
H
E
K
-----------
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
----------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
---
M
R
L
A
K
I
S
--
I
V
I
V
S
Q
----
F
---------
L
L
S
--
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E-
W
--------
V
T
------
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
-----------------
31
HHSearch
76.15
16%
-155
- C5 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
------------------------------------
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
-----
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
-
V
N
G
W
I
F
G
T
F
------
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
-
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
H
-----
P
-----
N
N
S
S
P
V
C
Y
E
V
L
G
N
D
-------
T
----------
A
K
-
W
R
M
V
L
-
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
-
L
R
T
L
F
K
---------
A
H
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
---
H
R
A
M
R
V
I
--
F
A
V
V
L
I
----
F
---------
L
L
C
--
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
R
T
--
Q
VIQE
S
C
E
R
R
N
N
I
----
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
-----------------