@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O52N4_HUMAN: (2016-01-12 )
MLTLNKTDLIPASFILNGVPGLEDTQLWISFPFCSMYVVAMVGNCGLLYLIHYEDALHKPMYYFLAMLSFTDLVMCSSTIPKALCIFWFHLKDIGFDECLVQMFFTHTFTGMESGVLMLMALDRYVAICYPLRYSTILTNPVIAKVGTATFLRGVLLIIPFTFLTKLLPYCRGNILPHTYCDHMSVAKLSCGNVKVNAIYGLMVALLIWGFDILCITNSYTMILRAVVSLSSADARQKAFNTCTAHICAIVFSYTPAFFSFFSHRFGEHIIPPSCHIIVANIYLLLPPTMNPIVYGVKTKQIRDCVIRILSGSKDTKSYSM
Atome Classification :
(20 SA)
----------..-.......10........20---------.........30..------......40..---......50........60........70........-80......------..90..--......100..---------.....110.......120.......130------........140--------------.......----------.150.......160.......------170..------.....180.......190-------.......200.......---------------------------210------.........220...-..----------..230.-----------------------------------------------------------------------------------------------------------------------------------------------------------------......240......-----.250.-------....-..-260.......270-----.--.----.......--280..-.....290.......300--..--......310-----------.........320---------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------ML-TLNKTDLI
P
A
S
F
I
LNGVP----------GLED
T
Q
L
W
I
SF
P
F
------
C
S
M
Y
V
V
A
M
VG---NC
G
L
L
Y
L
I
HYE
D
A
L
H
K
P
M
Y
Y
F
L
A
M
L
S
F
T
D
L
V
M
CSST-I
P
K
A
L
C
I
F
------
W
F
H
L
K
D--I
G
F
D
E
C
L
V
Q
M
F
---------
F
T
H
T
FT
G
M
E
S
G
V
L
M
L
M
A
L
D
R
Y
V
A
I
CYP-------LR
Y
S
T
ILTN
P
---------------
V
I
A
KV
G
T
----------
A
T
F
L
R
G
V
L
L
I
I
P
F
T
F
L
T
K
L
L
P
------
Y
C
RGN------ILPHTYCDHM
S
V
A
KLSCG-------
N
V
K
V
N
A
I
Y
G
L
M
V
A
L
L
I
W---------------------------G--------
F
D
I
L
C
IT
N
S
Y
T
M
I
L
R
-
A
V
----------
V
SLSS
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
R
Q
K
A
F
N
T
C
T
A
H
I
C
-----
A
I
V
F
S-------Y
T
P
A
-
F
F
-
S
F
F
S
H
R
FGEHI-------I--P----PS
C
H
I
I
V
--
A
N
I
Y
L
-LLPPTM
N
P
I
V
YGV
K
T
K
Q
---
I
R
--
D
C
V
I
R
I
L-------------SGSKDTKSYSM----------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
93.28
20%
-134
- C2 -
3PQR
11
OPSD_BOVIN
A:
[15-326]
---------------
N
K
T
G
V
V
R
S
P
F
------------------
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
------
L
H
G
Y
F
V
--
F
G
P
T
G
C
N
L
E
G
F
---------
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-------
M
S
N
F
R
F
G
E
N
H
---------------
A
I
M
G
V
A
F
----------
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
EGM---
Q
C
S
C
G
------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
-------
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
---------------------------
G
--------
Q
L
V
F
T
V
K
-------
E
-
A
A
----------
A
Q
Q
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
-----
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
-
A
F
-
Y
I
F
T
H
Q
-
G
S
D
F
-------
G
--
P
------
I
F
M
T
I
--
P
A
F
F
A
-
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
---
F
R
--
N
C
M
V
T
T
L
-------------
C
C
G
K
N
----------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
92.88
20%
-132
- C2 -
4J4Q
10
GNAT1_BOVIN (first)
A:
[15-326]
---------------
N
K
T
G
V
V
R
S
P
F
------------------
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
------
L
H
G
Y
F
V
--
F
G
P
T
G
C
N
L
E
G
F
---------
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-------
M
S
N
F
R
F
G
E
N
H
---------------
A
I
M
G
V
A
F
----------
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
EGM---
Q
C
S
C
G
------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
-------
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
---------------------------
G
--------
Q
L
V
F
T
V
K
-------
E
-
A
A
----------
A
Q
Q
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
-----
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
-
A
F
-
Y
I
F
T
H
Q
-
G
S
D
F
-------
G
--
P
------
I
F
M
T
I
--
P
A
F
F
A
-
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
---
F
R
--
N
C
M
V
T
T
L
-------------
C
C
G
K
N
----------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
92.46
20%
-134
- C2 -
3DQB
8
GNAT1_BOVIN (first)
A:
[15-326]
---------------
N
K
T
G
V
V
R
S
P
F
------------------
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
------
L
H
G
Y
F
V
--
F
G
P
T
G
C
N
L
E
G
F
---------
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-------
M
S
N
F
R
F
G
E
N
H
---------------
A
I
M
G
V
A
F
----------
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
EGM---
Q
C
S
C
G
------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
-------
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
---------------------------
G
--------
Q
L
V
F
T
V
K
-------
E
-
A
A
----------
A
Q
Q
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
-----
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
-
A
F
-
Y
I
F
T
H
Q
-
G
S
D
F
-------
G
--
P
------
I
F
M
T
I
--
P
A
F
F
A
-
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
---
F
R
--
N
C
M
V
T
T
L
-------------
C
C
G
K
N
----------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
91.56
20%
-136
- C2 -
3C9L
14
OPSD_BOVIN
A:
[15-326]
---------------
N
K
T
G
V
V
R
S
P
F
------------------
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
------
L
H
G
Y
F
V
--
F
G
P
T
G
C
N
L
E
G
F
---------
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-------
M
S
N
F
R
F
G
E
N
H
---------------
A
I
M
G
V
A
F
----------
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GM---
Q
C
S
C
G
------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
-------
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
---------------------------
G
--------
Q
L
V
F
T
V
K
-------
E
-
A
A
----------
A
Q
Q
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
-----
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
-
A
F
-
Y
I
F
T
H
Q
-
G
S
D
F
-------
G
--
P
------
I
F
M
T
I
--
P
A
F
F
A
-
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
---
F
R
--
N
C
M
V
T
T
L
-------------
C
C
G
K
N
D
D
E
-------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
91.15
20%
-128
- C2 -
3CAP
8
OPSD_BOVIN
A:
[15-326]
---------------
N
K
T
G
V
V
R
S
P
F
------------------
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
------
L
H
G
Y
F
V
--
F
G
P
T
G
C
N
L
E
G
F
---------
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-------
M
S
N
F
R
F
G
E
N
H
---------------
A
I
M
G
V
A
F
----------
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
EGM---
Q
C
S
C
G
------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
-------
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
---------------------------
G
--------
Q
L
V
F
T
V
K
-------
E
-
A
A
----------
A
Q
Q
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
-----
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
-
A
F
-
Y
I
F
T
H
Q
-
G
S
D
F
-------
G
--
P
------
I
F
M
T
I
--
P
A
F
F
A
-
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
---
F
R
--
N
C
M
V
T
T
L
-------------
C
C
G
K
N
----------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
90.96
20%
-132
- C2 -
3PXO
6
OPSD_BOVIN
A:
[15-326]
---------------
N
K
T
G
V
V
R
S
P
F
------------------
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
------
L
H
G
Y
F
V
--
F
G
P
T
G
C
N
L
E
G
F
---------
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-------
M
S
N
F
R
F
G
E
N
H
---------------
A
I
M
G
V
A
F
----------
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
EGM---
Q
C
S
C
G
------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
-------
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
---------------------------
G
--------
Q
L
V
F
T
V
K
-------
E
-
A
A
----------
A
Q
Q
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
-----
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
-
A
F
-
Y
I
F
T
H
Q
-
G
S
D
F
-------
G
--
P
------
I
F
M
T
I
--
P
A
F
F
A
-
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
---
F
R
--
N
C
M
V
T
T
L
-------------
C
C
G
K
N
----------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
90.74
20%
-108
- C2 -
3OAX
18
OPSD_BOVIN
A:
[18-327]
---------------
N
K
T
G
V
V
R
S
P
F
------------------
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
------
L
H
G
Y
F
V
--
F
G
P
T
G
C
N
L
E
G
F
---------
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-------
M
S
N
F
R
F
G
E
N
H
---------------
A
I
M
G
V
A
F
----------
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GM---
Q
C
S
C
G
------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
-------
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
---------------------------
G
--------
Q
L
V
F
T
V
K
-------
E
-
A
A
----------
A
Q
Q
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
-----
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
-
A
F
-
Y
I
F
T
H
Q
-
G
S
D
F
-------
G
--
P
------
I
F
M
T
I
--
P
A
F
F
A
-
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
---
F
R
--
N
C
M
V
T
T
L
-------------
C
C
G
K
N
P
L
G
D
D
E
----------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
89.97
20%
-133
- C2 -
4PXF
9
OPSD_BOVIN
A:
[15-326]
---------------
N
K
T
G
V
V
R
S
P
F
------------------
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
------
L
H
G
Y
F
V
--
F
G
P
T
G
C
N
L
E
G
F
---------
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-------
M
S
N
F
R
F
G
E
N
H
---------------
A
I
M
G
V
A
F
----------
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
EGM---
Q
C
S
C
G
------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
-------
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
---------------------------
G
--------
Q
L
V
F
T
V
K
-------
E
-
A
A
----------
A
Q
Q
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
-----
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
-
A
F
-
Y
I
F
T
H
Q
-
G
S
D
F
-------
G
--
P
------
I
F
M
T
I
--
P
A
F
F
A
-
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
---
F
R
--
N
C
M
V
T
T
L
-------------
C
C
G
K
N
----------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
89.91
17%
-142
* C2 *
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
-----------------------------------------------
M
P
L
V
V
V
L
------
S
T
I
C
L
V
T
V
G
L
---
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
------
L
M
S
K
W
S
--
L
G
R
P
L
C
L
F
W
L
S
---------
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
-------
L
R
Y
L
K
Y
R
T
K
T
---------------
R
A
S
A
T
I
L
----------
G
A
W
F
L
S
F
L
W
V
I
P
I
L
-
G
W
N
H
--------------------
R
R
E
D
K
C
E
T
D
F
Y
D
----------------
V
T
W
F
K
V
M
T
A
I
I
N
F
---------------------------
Y
--------
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
-
A
V
----------
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
-----
A
F
I
L
C
-------
W
I
P
Y
-
F
I
-
F
F
M
V
I
A
F
C
K
N
C
----------
C
----
N
E
H
L
H
M
F
--
T
I
W
L
G
-
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
---
F
K
--
K
T
F
K
R
I
L
-------------
H
I
-------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
89.38
20%
-131
- C2 -
1F88
8
OPSD_BOVIN
A:
[15-326]
---------------
N
K
T
G
V
V
R
S
P
F
------------------
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
------
L
H
G
Y
F
V
--
F
G
P
T
G
C
N
L
E
G
F
---------
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-------
M
S
N
F
R
F
G
E
N
H
---------------
A
I
M
G
V
A
F
----------
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GM---
Q
C
S
C
G
------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
-------
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
---------------------------
G
--------
Q
L
V
F
T
V
K
-------
E
-
A
A
----------
A
----
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
-----
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
-
A
F
-
Y
I
F
T
H
Q
-
G
S
D
F
-------
G
--
P
------
I
F
M
T
I
--
P
A
F
F
A
-
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
---
F
R
--
N
C
M
V
T
T
L
-------------
C
C
G
K
N
P
S
T
T
V
S
----------------------------------------------------------------------------------------------------------------------------------
42
Fugue
87.66
17%
-122
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFY
V
P
-
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L---------
A
E
P
W
Q
F
S
M
L
A
A
Y
M
------
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
------
L
H
G
Y
F
V
--
F
G
P
T
G
C
N
L
E
G
F
---------
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-------
M
S
N
F
R
F
G
E
N
H
---------------
A
I
M
G
V
A
F
----------
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
------
E
--
G
-------------------
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
---------------------------
I
--------
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-
T
V
----------
K
E
A
A
A
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
-----
I
M
V
I
A
-------
F
L
I
C
-
W
L
-
P
Y
A
G
V
A
F
Y
I
F
T
-------
H
--
Q
GSDF
G
P
I
F
M
T
I
--
P
A
F
F
A
-
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
---
F
R
--
N
C
M
V
T
T
L
-------------
C
C
G
K
N
P
S
T
T
V
S
KTETS
Q
V
A
P
A------------------------------------------------------------------------------------------------------------------------
43
Fugue
84.87
18%
-103
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
SPFEAPQYYL
A
E
P
W
Q
F
S
M
L
A
A
Y
M
------
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
------
L
H
G
Y
F
V
--
F
G
P
T
G
C
N
L
E
G
F
---------
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-------
M
S
N
F
R
F
G
E
N
H
---------------
A
I
M
G
V
A
F
----------
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
------
E
--
G
-------------------
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
---------------------------
I
--------
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-
T
V
----------
K
E
A
A
A
Q
QQES-------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
-----
I
M
V
I
A
-------
F
L
I
C
-
W
L
-
P
Y
A
G
V
A
F
Y
I
F
T
-------
H
--
Q
GSDF
G
P
I
F
M
T
I
--
P
A
F
F
A
-
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
---
F
R
--
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
APA-------------------------------------------------------------------------------------------------------------------------------
50
Fugue
84.67
18%
-120
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
--------------
S
F
K
C
A
L
T
K
T
G
F
--------------------
Q
F
Y
Y
L
P
A
V
Y
------
I
L
V
F
I
I
G
F
L
G
---
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
-
L
P
-
A
L
I
F
Y
------
Y
F
N
K
T
D
WI
F
G
D
A
M
C
K
L
Q
R
F
---------
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-------
K
S
L
G
R
L
K
K
K
N
---------------
A
I
C
-
I
S
V
----------
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
R
KNKTI
T
C
Y
D
T
TSDEY
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
-------
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNP
G
--------
T
D
F
K
D
I
V
C
P
L
C
G
V
G
K
-
D
Q
----------
F
E
E
V
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
-----
V
F
A
V
S
-------
Y
I
P
F
H
V
M
-
K
T
M
N
L
R
A
R
L
D
F
-------
Q
--
T
----
P
A
M
C
A
F
N
--
D
R
V
Y
A
-
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
---------
N
P
I
L
Y
F
L
-------------
A
G
D
T
F
R
R
R
-------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
84.25
17%
-138
- C2 -
2KS9
1
NK1R_HUMAN
A:
[34-325]
------------------------------------------------
L
W
A
A
A
Y
------
T
V
I
V
V
T
S
V
V
G
---
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
------
V
H
N
E
W
Y
--
Y
G
L
F
Y
C
K
F
H
N
F
---------
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
-------
L
Q
P
R
L
--
S
A
T
---------------
A
T
K
V
V
I
C
----------
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
-------
T
----------
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
----------
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
---------------------------
F
--------
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
-
T
L
----------
W
A
S
E
I
P
GDSSDRYH
E
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
-----
T
F
A
I
C
-------
W
L
P
F
-
H
I
-
F
F
L
L
P
Y
I
N
P
D
L
-------
Y
L-
K
KF--
I
Q
Q
V
Y
L
A
--
I
M
W
L
A
-
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
---
F
R
--
L
G
F
K
H
A
F
-------------
R
C
C
P
F
I
S
A
G
D
Y
----------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
84.08
17%
-134
- C2 -
2Z73
5
OPSD_TODPA
A:
[32-334]
--------------------------------------------
A
V
Y
Y
S
L
G
I
F
I
------
G
I
C
G
I
I
G
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
------
F
L
K
K
W
I
--
F
G
F
A
A
C
K
V
Y
G
F
---------
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
-------
M
A
A
S
K
K
M
S
H
R
---------------
R
A
F
I
M
I
I
----------
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
------
L
----------
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
------------
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
---------------------------
F
--------
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
-
S
V
----------
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
---------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
-----
Q
F
L
L
S
-------
W
S
P
Y
-
A
V
-
V
A
L
L
A
Q
F
G
P
L
E
-------
W
--
V
----
T
P
Y
A
A
Q
L
--
P
V
M
F
A
-
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
---
F
R
--
E
A
I
S
Q
T
F
-------------
P
W
V
L
T
C
C
Q
F
D
D
----------------------------------------------------------------------------------------------------------------------------------
44
Fugue
75.90
18%
-147
* C3 *
4Q9T
-
?
A:
[12-446]
-------TKI
L
T
-
E
T
E
K
Y
S
V
T
K
L
S
T
D
L
S
F
L
P
F
E
--------
G
L
V
D
T
A
L
----------------
Q
K
A
L
V
N
---
D
L
D
H
I
Y
I
W
N
Y
N
S
I
Q
K
D
T
P
I
C
K
I
S
L
H
S
S
P
P
I
C
L
F
T
S
S
-
I
-
N
G
I
C
I
I
N
KKNS
Q
F
L
Y
F
E
D
--
I
S
T
I
N
N
L
A
H
V
L
D
LKLKDNEN
I
T
S
T
I
N
C
E
P
S
G
I
I
I
A
T
S
L
G
R
V
L
F
I
T
I
K
DSTGK
P
K
L
E
L
K
Q
Q
L
I
K
P
QNSFFFRNLDSSKEI
I
S
L
K
K
G
P
I
V
G
KG
E
R
L
L
Y
I
T
T
R
G
G
S
L
Q
I
W
Q
L
S
I
N
S
K
S
F
K
------
R
L
E
I
N
------
I
Y
E
H
V
L
D
S
L
Q
D
L
Y
P
F
A
H
G
-------
T
L
A
F
L
D
S
H
P
I
Y
S
D
T
S
S
A
---------------------------
H
--------
L
T
L
A
S
I
S
N
G
N
E
I
Y
Y
L
M
I
T
----------
V
I
L
D
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
N
S
F
Q
I
F
S
I
Y
K
L
N
T
Y
-----
F
T
K
S
T
-------
V
D
L
N
-
H
K
P
Q
L
F
I
P
N
A
L
D
S
I
-------
V
--
S
----
P
T
L
S
V
Y
V
L
F
N
N
A
V
V
M
T
Q
I
S
S
K
L
D
S
S
F
P
L
R
R
K
W
E
D
I
I
R
F
-
N
K
D
V
E
I
I
-------------
G
S
G
Y
S
T
D
S
I
Y
V
I
C
KDM
G
V
L
K
I
A
S
H---------------------------------------------------------------------------------------------------------------------
35
HHSearch
74.70
16%
-138
- C2 -
3V2Y
1
ENLYS_BPT4
A:
[61-495]
--------------------------------------------
N
S
I
K
L
T
S
V
V
F
------
I
L
I
C
C
F
I
I
L
E
---
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
------
A
-
T
T
Y
K
--
L
T
P
A
Q
W
F
L
R
E
G
---------
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
---------------
N
N
F
---------------
R
L
F
L
L
I
S
----------
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
G
W
N
C
I
-------------------
S
A
L
S
S
C
S
T
V
L
P
L
---------------
Y
H
K
H
Y
I
L
F
-
C
T
T
V
F
---------------------------
T
--------
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
-
L
V
----------
R
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
S
S
E
N
V
A
L
L
K
T
V
I
I
V
L
S
-----
V
F
I
A
C
-------
W
A
P
L
-
F
I
-
L
L
L
L
D
V
G
C
K
V
K
T------
C
--
D
----
I
L
F
R
A
E
Y
--
F
L
V
L
A
-
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
---
M
R
--
R
A
F
I
R
I
M
-------------
G
R
P
L
-----------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
73.09
15%
-120
- C2 -
1U19
14
OPSD_BOVIN
A:
[41-329]
-----------------------------------------------
S
M
L
A
A
Y
M
------
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
------
L
H
G
Y
F
V
--
F
G
P
T
G
C
N
L
E
G
F
---------
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-------
M
S
N
F
R
-
F
G
E
N
---------------
H
A
I
M
G
V
A
----------
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
------
P
----------
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
----------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
---------------------------
I
--------
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-
T
V
----------
K
E
A
A
A
Q
QQESA
T
T
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
-----
A
F
L
I
C
-------
W
L
P
Y
-
A
G
-
V
A
F
Y
I
F
T
H
Q
G
S
-------
D
--
F
----
G
P
I
F
M
T
I
--
P
A
F
F
A
-
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
---
F
R
--
N
C
M
V
T
T
L
-------------
C
C
G
K
N
P
L
G
D
D
E
----------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
72.54
15%
-129
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
--------------------------------------------
L
N
K
Y
V
V
I
I
A
Y
------
A
L
V
F
L
L
S
L
L
G
---
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
-------
V
N
G
W
I
--
F
G
T
F
L
C
K
V
V
S
L
---------
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
-------
T
R
T
L
T
-
Q
K
R
H
---------------
L
V
K
F
V
C
L
----------
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
H
------
P
----------
N
N
S
S
P
V
C
Y
E
V
L
G
N
D
T
-----------
A
K
W
R
M
V
L
R
I
L
P
H
T
F
G
F
---------------------------
I
--------
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
-
T
L
----------
F
K
A
H
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
-----
I
F
L
L
C
-------
W
L
P
Y
-
N
L
-
V
L
L
A
D
T
L
M
R
T
Q
VIQE
S
C
E
R
R
N
N
----
I
G
R
A
L
D
A
--
T
E
I
L
G
-
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
---
F
R
--
H
G
F
L
K
I
L
-------------
A
M
H
G
-----------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
71.56
13%
-132
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
---------------------
P
C
F
R
E
E
N
A
--------------
N
F
N
K
I
F
L
P
T
I
Y
------
S
I
I
F
L
T
G
I
V
G
---
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
-
T
-
L
P
F
W
A
V
D
A
------
V
A
N
W
Y
F
---
G
N
F
L
C
K
A
V
H
V
---------
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
-------
T
N
S
Q
R
P
R
K
L
L
---------------
A
E
K
V
V
Y
V
----------
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
S
E
A
DD
R
Y
-
I
C
D
R
F
------
Y
P
N
D
L
W
V
V
V
F
Q
F
Q
H
I
M
V
G
-------
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
---------------------------
K
LSHSGSN
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
-
K
D
TEG
Y
Y
T
I
GIG
H
L
L
T
K
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
RNTNG
V
I
T
K
D
-------
E
A
E
K
-
L
F
-
N
Q
D
V
D
A
A
V
R
G
I
-------
L
--
R
N---
A
K
L
K
P
V
Y
--
D
S
L
D
A
-
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
---
V
A
G
F
T
N
S
L
R
M
L
-------------
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ