@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O5H15_HUMAN: (2016-01-12 )
MEEENATLLTEFVLTGFLYQPQWKIPLFLAFLVIYLITIMGNLGLIAVIWKDPHLHIPMYLLLGNLAFVDAWISSTVTPKMLNNFLAKSKMISLSECKIQFFSIAIGVTTECFLLATMAYDRYVAICKPLLYPAIMTNGLCIRLLILSYIAGILHALIHEGFLFRLTFCNSNIVHHIYCDTIPLSKISCTDSSINFLMVFIFSGSIQVFSIVTILISYTFVLFTVLEKKSDKGVRKAFSTCGAHLFSVCLYYGPLLLMYVGPASPQADGQNMVEPLFYTVIIPLLNPIIYSLRNKQVIVSFIKMLKRNVKVSY
Atome Classification :
(20 SA)
------------.........10...----.....20-------..----.......30.-......-.40........50----.........60..--......70...---------...-..80........90...--------..--...100.......110.......120.......130..--...-------.-------------.140.......150--........160.......170.......--180...-....------------190..-...-..--200.......210.......220...-----------....230---------.--------------------........240---.......----------.250....-------...260..------..---.----..--270-........280.......290.......300......---------------.310.-------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MEEE
N
A
T
L
L
T
E
F
V
L
----
T
G
FLYQ--------PQ----WK
I
P
L
F
L
A
F
L
-
V
I
Y
L
I
T
-
I
MGNL
G
L
I
A
V
I
W-----KDPHLH
I
P
M
Y
L
L
L--G
N
L
A
F
V
D
A
W
I
S---------STV-
T
P
K
M
L
N
N
F
L
A
KSK
M
I
SL--------SE--
C
K
I
Q
F
F
S
I
A
IGVT
T
E
C
F
L
L
A
T
M
A
Y
D
R
Y
V
A
I
C
K
P
L
L
Y
P
A
--
I
MT-------N-------------
G
L
C
I
R
L
L
I
L
S
Y
I
A
---
G
I
L
H
A
L
I
HE
G
F
L
F
R
L
T
FCNSN
I
V
H
H
I
Y
C--DTIPLS-
K
I
SC------------TDSS
I
-
N
F
L
-
M
V
--
F
I
FSGSI
Q
V
F
S
I
V
T
I
L
I
S
Y
T
F
V
L
F
T
V
-----------
L
E
KKS-----------
D
--------------------
K
G
V
R
K
A
F
S
T
C
----
G
A
H
L
F
S
V
----------
C
L
Y
YG
P
L
L
-------
L
M
Y
VGPAS------PQ---A----DG--
Q
N
--
M
V
E
P
L
F
Y
T
V
I
I
P
L
L
N
P
I
I
Y
S
LRN
K
Q
V
I
V
S
F
I
K
M
L
K
R
N---------------VKVSY-------------
38
HHSearch
88.07
17%
-136
- C6 -
2Z73
5
OPSD_TODPA
A:
[34-333]
---------------------------------------------------
Y
Y
S
L
G
I
F
I
G
-
I
C
G
I
I
G
-
C
G
G
N
G
I
V
I
Y
L
F
T
-----
K
T
K
S
L
Q
T
P
A
N
M
F
I
--
I
N
L
A
F
S
D
F
T
F
S
---------
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
--------
A
A
--
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
--
K
M
S
-------
H
-------------
R
R
A
F
I
M
I
I
F
V
W
L
W
---
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
---
T
-
L
E
G
V
L
C
N
C
--
S
F
D
Y
I
S
------------------
R
D
S
T
-
T
R
S
-
N
I
--
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
-----------
S
N
H
E
K
-----------
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
----
I
V
I
V
S
Q
F
----------
L
L
S
W
S
P
Y
A
-------
V
V
A
L
L
A
Q
F
------
G
P
LEW
V
----
T
P
--
Y
A
--
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
---------------
L
T
C
C
Q
-------------
45
Fugue
86.47
19%
-116
- C6 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
----
P
Q
Y
Y
L
A
--------
E
P
----
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
-
F
P
I
N
F
L
T
L
Y
V
T
V
-----
Q
H
K
K
L
R
T
P
L
N
Y
I
L
--
L
N
L
A
V
A
D
L
F
M
V
---------
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
--------
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
--------------------------------------
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
--
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTPHEETN
N
E
S
F
V
-
I
Y
M
-
F
V
--
V
H
F
-----
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
KEAAAQQQESA
T
T
Q
K
A
-----------
E
--------------------
K
E
V
T
R
M
V
I
I
M
----
V
I
A
F
L
I
C
----------
W
L
P
Y
A
G
V
A
-------
F
Y
I
F
T
H
Q
G
------
S
D
---
F
----
G
P
--
I
F
--
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
KNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
VAPA---------
34
HHSearch
83.69
17%
-141
- C6 -
2KS9
1
NK1R_HUMAN
A:
[35-324]
------------------------------------------------------
W
A
A
A
Y
T
-
V
I
V
V
T
S
-
V
V
G
N
V
V
V
M
W
I
I
L
-----
A
H
K
R
M
R
T
V
T
N
Y
F
L
--
V
N
L
A
F
A
E
A
S
M
A
---------
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
--------
F
Y
--
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
----
S
-------
A
-------------
T
A
T
K
V
V
I
C
V
I
W
V
L
---
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
----
E
-
T
M
P
S
R
V
V
C
--
M
I
E
W
P
E
-
H
P
N
---------------
K
I
Y
-
E
K
V
-
Y
H
--
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
-----------
W
A
S
E
I
PGDSSDRYH
E
Q
V
--------------------
S
A
K
R
K
V
V
K
M
M
----
I
V
V
V
C
T
F
----------
A
I
C
W
L
P
F
H
-------
I
F
F
L
L
P
Y
I
------
N
P
---
D
LYL-
K
K
F-
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
---------------
P
F
I
S
A
-------------
44
Fugue
83.53
16%
-125
- C6 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
----
P
Q
Y
Y
L
A
--------
E
P
----
W
Q
F
S
M
L
A
A
Y
M
-
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
-----
Q
H
K
K
L
R
T
P
L
N
Y
I
L
--
L
N
L
A
V
A
D
L
F
M
V
---------
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
--------
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
---
F
G
-------
E
-------------
N
H
A
I
M
G
V
A
F
T
W
V
M
---
A
L
A
C
A
A
P
P
L
V
G
W
S
R
--
Y
I
P
E
G
M
Q
C
S
C
G
I
--
D
Y
Y
T
P
H
-
E
E
T
N
------------
N
E
S
F
V
-
I
Y
M
-
F
V
VH
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
S
A
-----------
T
T
Q
K
A
-----------
E
--------------------
K
E
V
T
R
M
V
I
I
M
----
V
I
A
F
L
I
C
----------
W
L
P
Y
A
G
V
A
-------
F
Y
I
F
T
H
Q
G
------
S
D
---
F
----
G
P
--
I
F
--
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
---------------
K
N
P
S
T
TVSKTETS
Q
V
A
P
A
35
HHSearch
79.38
17%
-133
- C6 -
1U19
14
OPSD_BOVIN
A:
[42-326]
-----------------------------------------------------
M
L
A
A
Y
M
F
-
L
L
I
M
L
G
-
F
P
I
N
F
L
T
L
Y
V
T
V
-----
Q
H
K
K
L
R
T
P
L
N
Y
I
L
--
L
N
L
A
V
A
D
L
F
M
V
---------
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
--------
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
---
F
G
-------
E
-------------
N
H
A
I
M
G
V
A
F
T
W
V
M
---
A
L
A
C
A
A
P
P
L
V
G
W
S
R
--
Y
-
I
-
P
E
G
M
Q
C
S
C
--
G
I
D
Y
Y
T
-
P
---------------
H
E
E
T
N
-
N
E
S
-
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-----------
K
E
A
A
A
-----------
Q
QQESA
T
T
Q
------------
K
A
E
K
E
V
T
R
M
V
----
I
I
M
V
I
A
F
----------
L
I
C
W
L
P
Y
A
-------
G
V
A
F
Y
I
F
T
H
-----
Q
G
SD-
F
----
G
P
--
I
F
--
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
---------------
K
N
P
L
G
-------------
32
HHSearch
71.84
17%
-127
- C6 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
--------------------------------------------------
N
K
Y
V
V
I
I
A
Y
A
-
L
V
F
L
L
S
-
L
L
G
N
S
L
V
M
L
V
I
L
-----
Y
S
R
V
G
R
S
V
T
D
V
Y
L
--
L
N
L
A
L
A
D
L
L
F
A
---------
L
-
T
-
L
P
I
W
A
A
S
K
V
-
N
G
W
I
F
G
T
--------
F
L
--
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
---
Q
K
-------
R
-------------
H
L
V
K
F
V
C
L
G
C
W
G
L
---
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
--
Y
-
H
P
-
N
N
S
S
P
V
C
--
Y
E
V
L
G
N
-
D
----------------
T
A
K
W
-
R
M
V
-
L
R
--
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
-----------
F
K
A
H
------------
M
--------------------
G
Q
K
H
R
A
M
R
V
I
----
F
A
V
V
L
I
F
----------
L
L
C
W
L
P
Y
N
-------
L
V
L
L
A
D
T
L
M
RTQVI
Q
E
---
S
C
E
R
R
N
N
I
G
R
A
--
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
---------------
G
-----------------
28
HHSearch
65.60
20%
-138
- C6 -
2RH1
6
ADRB2_HUMAN (first)
A:
[41-235]
----------------------------------------------------
V
G
M
G
I
V
M
S
-
L
I
V
L
A
I
-
V
F
G
N
V
L
V
I
T
A
I
A
-----
K
F
E
R
L
Q
T
V
T
N
Y
F
I
--
T
S
L
A
C
A
D
L
V
M
G
---------
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
--------
F
W
--
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
--
L
L
T
-------
K
-------------
N
K
A
R
V
I
I
L
M
V
W
I
V
---
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
-
A
---
T
H
Q
E
A
I
N
C
--
Y
A
E
-----
E
T
C
------------
C
D
F
F
T
-
N
Q
A
-
Y
A
--
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
-----------
K
R
Q
L
N
-----------
I
--------------------
F
E
M
L
R
I
D
E
G
L
----
R
L
K
I
Y
K
D
----------
T
E
G
Y
Y
T
I
G
-------
I
G
H
L
L
T
K
S
------
P
S
---
L
----
N
A
--
A
K
--
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
---------------
N
A
K
L
K
-------------
49
Fugue
64.53
11%
-139
- C4 -
3FEH
3
ADAP1_HUMAN
A:
[13-375]
--------N
L
Y
F
Q
G
K
E
R
R
R
A
V
L
E
L
L
Q
----
R
P
G
N
A
R
CADCGAPD
P
D
----
W
A
S
Y
T
L
G
V
F
I
-
C
L
S
C
S
G
-
I
H
R
N
I
P
Q
V
S
K
V
K
S
VRL
D
A
W
E
E
A
Q
V
E
F
M
A
S
H
--
G
N
D
A
A
R
A
R
F
E
S
KVPSF
Y
Y
R
P
T
P
S
-
D
C
Q
L
L
R
E
Q
W
I
R
A
K
Y
E
R
Q
--------
E
F
--
I
Y
P
E
K
Q
E
P
Y
S
A
G
Y
R
E
G
F
L
W
K
R
G
R
D
N
G
Q
F
L
S
R
K
F
V
L
T
E
R
EG
A
L
K
Y
F
N
RNDA
K
-------------
E
P
K
A
V
M
K
I
E
H
L
N
A
---
T
F
Q
P
A
K
I
G
H
P
H
G
L
Q
V
T
Y
L
K
D
N
S
T
R
N
I
F
I
--
Y
H
E
D
G
K
-
E
I
V
D
------------
W
F
N
A
L
-
R
A
A
-
R
F
--
H
Y
L
Q
V
A
F
P
G
A
S
D
A
D
L
V
P
K
L
S
R
N
Y
L
K
E
-----------
G
Y
M
E
K
-----------
T
--------------------
G
F
R
K
R
W
F
T
M
D
----
D
R
R
L
M
Y
F
KDPLDAFAR
G
E
V
F
I
G
S
K
E
-------
S
G
Y
T
V
L
H
G
------
F
P
---
P
----
S
T
--
Q
G
--
H
H
W
P
H
G
I
T
I
V
T
P
D
-
R
K
F
L
F
A
C
E
T
E
S
D
Q
R
E
W
V
A
A
F
Q
K
A
---------------
V
D
R
P
M
-------------
2
PsiBlast_PDB
63.44
25%
-141
- C6 -
4IAR
1
C562_ECOLX
A:
[9-149]
--------------------------------
Y
I
Y
Q
--------
D
S
IS
L
P
W
K
V
L
L
V
M
L
L
A
-
L
I
T
L
A
T
-
T
L
S
N
A
F
V
I
A
T
V
Y
-----
R
T
R
K
L
H
T
P
A
N
Y
L
I
--
A
S
L
A
V
T
D
L
L
V
S
---------
I
L
V
-
M
P
--
I
S
T
M
Y
T
V
T
G
R
W
T
L
--------
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
W
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
A
V
E
Y
S
A
--
K
R
T
-------
P
-------------
K
R
A
A
V
M
I
A
L
V
W
V
F
---
S
I
S
I
S
L
P
P
F
F
W
R
Q
A
S
E
C
V
V
N
T
D
H
I
L
Y
T
V
--
Y
S
T
V
G
A
-
F
Y
F
P
------------
T
L
L
L
I
-
A
L
Y
-
G
R
--
I
Y
V
E
A
R
S
R
I
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
-----------
E
K
A
D
N
-----------
A
--------------------
A
Q
V
K
D
A
L
T
K
M
----
R
A
A
A
L
D
A
----------
Q
K
A
T
P
P
K
L
-------
E
D
K
S
P
D
S
P
------
E
M
---
K
----
D
F
--
R
H
--
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
---------------
Y
I
Q
K
Y
-------------
47
Fugue
61.87
12%
-155
- C1 -
4L8T
-
A:
[64-447]
----EYLG
M
L
Q
Y
K
R
E
D
E
A
K
L
I
Q
N
L
I
L
DLKP
R
G
V
V
V
N
--------
M
I
----
P
G
L
P
A
H
I
L
F
M
-
C
V
R
Y
A
D
-
S
L
N
D
A
N
M
L
K
S
L
M
-----
N
S
T
I
N
G
I
K
Q
V
V
K
E
H
L
E
D
F
E
M
L
S
F
W
L
S
---------
N
T
C
---
H
F
L
N
C
L
K
Q
Y
S
G
E
E
E
F
MKHNS
P
Q
Q
N
K
--
N
C
L
N
N
F
D
L
-
S
E
Y
R
Q
I
L
S
D
V
A
I
R
I
Y
H
Q
F
I
I
I
M
E
K
N
I
Q
P
I
--
I
V
P
-------
G
M
LEYESLQGYT
M
T
S
V
L
Q
Q
L
S
Y
F
Y
T
T
M
C
Q
N
G
L
D
P
E
L
V
R
Q
A
V
K
Q
L
F
F
L
I
G
A
V
T
L
N
S
L
F
L
RK
D
M
C
S
C
R
-
K
G
M
Q
------------
I
R
C
N
I
-
S
Y
L
-
E
E
--
W
L
K
D
K
N
L
Q
N
S
L
A
K
E
T
L
E
P
L
S
Q
A
A
W
L
L
Q
----------
V
K
K
T
T
-----------
D
--------------------
S
D
A
K
E
I
Y
E
R
C
TSLS
A
V
Q
I
I
K
I
----------
L
N
S
Y
T
P
I
D
DF
E
K
R
V
T
P
S
F
V
R
K
V
Q
------
A
L
---
L
----
N
S
--
R
E
--
D
S
S
Q
L
M
L
D
T
--
K
Y
L
F
Q
V
T
F
P
F
T
P
S
P
H
A
L
E
M
I
Q
-
I
P
S
S
---------------
F
K
L
G
F
LNRL---------
26
HHSearch
60.91
16%
-141
- C6 -
3UON
2
ACM2_HUMAN (first)
A:
[24-215]
----------------------------------------------------
V
F
I
V
L
V
A
G
-
S
L
S
L
V
T
-
I
I
G
N
I
L
V
M
V
S
I
K
-----
V
N
R
H
L
Q
T
V
N
N
Y
F
L
--
F
S
L
A
C
A
D
L
I
I
G
---------
V
F
S
-
M
N
L
Y
T
L
Y
T
V
I
G
Y
W
P
L
G
P
--------
V
V
--
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
--
K
R
T
-------
T
-------------
K
M
A
G
M
M
I
A
A
A
W
V
L
---
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
--
V
G
V
R
T
V
E
D
G
E
C
--
Y
I
Q
F
F
----------------------
S
-
N
A
A
-
V
T
--
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
-----------
K
S
R
I
N
-----------
I
--------------------
F
E
M
L
R
I
D
E
G
L
----
R
L
K
I
Y
K
D
----------
T
E
G
Y
Y
T
I
G
-------
I
G
H
L
L
T
K
S
------
P
S
---
L
----
N
A
--
A
K
--
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
---------------
N
A
K
L
K
-------------
27
HHSearch
60.27
16%
-135
- C6 -
3RZE
2
ENLYS_BPT4 (first)
A:
[11-200]
------------------------------------------------------
L
V
V
V
L
S
-
T
I
C
L
V
T
-
V
G
L
N
L
L
V
L
Y
A
V
R
-----
S
E
R
K
L
H
T
V
G
N
L
Y
I
--
V
S
L
S
V
A
D
L
I
V
G
---------
A
V
V
-
M
P
M
N
I
L
Y
L
L
M
S
K
W
S
L
G
R
--------
P
L
--
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
--
Y
R
T
-------
K
-------------
T
R
A
S
A
T
I
L
G
A
W
F
L
---
S
F
L
W
V
I
P
I
L
G
W
N
-
H
--------
R
R
E
D
K
C
--
E
T
D
F
Y
D
-----------------------
V
T
W
-
F
K
--
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
-----------
R
Q
H
C
N
-----------
I
--------------------
F
E
M
L
R
I
D
E
G
L
----
R
L
K
I
Y
K
D
----------
T
E
G
Y
Y
T
I
G
-------
I
G
H
L
L
T
K
S
------
P
S
---
L
----
N
A
--
A
K
--
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
---------------
N
A
K
L
K
-------------
1
PsiBlast_PDB
59.95
25%
-139
- C6 -
4IAQ
1
5HT1B_HUMAN (first)
A:
[9-149]
--------------------------------
Y
I
Y
Q
--------
D
S
IS
L
P
W
K
V
L
L
V
M
L
L
A
-
L
I
T
L
A
T
-
T
L
S
N
A
F
V
I
A
T
V
Y
-----
R
T
R
K
L
H
T
P
A
N
Y
L
I
--
A
S
L
A
V
T
D
L
L
V
S
---------
I
L
V
-
M
P
--
I
S
T
M
Y
T
V
T
G
R
W
T
L
--------
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
W
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
A
V
E
Y
S
A
--
K
R
T
-------
P
-------------
K
R
A
A
V
M
I
A
L
V
W
V
F
---
S
I
S
I
S
L
P
P
F
F
W
R
Q
A
S
E
C
V
V
N
T
D
H
I
L
Y
T
V
--
Y
S
T
V
G
A
-
F
Y
F
P
------------
T
L
L
L
I
-
A
L
Y
-
G
R
--
I
Y
V
E
A
R
S
R
I
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
-----------
N
A
A
Q
V
-----------
K
--------------------
D
A
L
T
K
M
R
A
A
A
----
L
D
A
Q
K
A
T
----------
P
D
S
P
E
M
K
D
-------
F
R
H
G
F
D
I
L
------
V
G
---
Q
----
I
D
--
D
A
--
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
L
M
A
A
R
E
---------------
R
K
A
T
K
-------------
11
PsiBlast_PDB
58.75
25%
-119
- C6 -
4AMI
1
ADRB1_MELGA
A:
[5-126]
---------------------------------
L
L
S
--------
Q
Q
----
W
E
A
G
M
S
L
L
M
A
-
L
V
V
L
L
I
-
V
A
G
N
V
L
V
I
A
A
I
G
-----
S
T
Q
R
L
Q
T
L
T
N
L
F
I
--
T
S
L
A
C
A
D
L
V
V
G
---------
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
--------
F
L
--
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
--
L
M
T
-------
R
-------------
A
R
A
K
V
I
I
C
T
V
W
A
I
---
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
--
G
C
C
D
F
V
-
T
N
R
A
------------
Y
A
I
A
S
-
S
I
I
-
S
F
--
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
L
M
R
E
H
-----------
K
A
L
K
T
-----------
L
--------------------
G
I
I
M
G
V
F
T
L
C
----
W
L
P
F
F
L
V
----------
N
I
V
N
V
F
N
R
-------
D
L
V
P
D
W
L
F
------
V
A
---
F
----
N
W
--
L
G
--
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------
12
PsiBlast_PDB
58.59
25%
-122
- C6 -
4AMJ
3
ADRB1_MELGA
A:
[5-126]
---------------------------------
L
L
S
--------
Q
Q
----
W
E
A
G
M
S
L
L
M
A
-
L
V
V
L
L
I
-
V
A
G
N
V
L
V
I
A
A
I
G
-----
S
T
Q
R
L
Q
T
L
T
N
L
F
I
--
T
S
L
A
C
A
D
L
V
V
G
---------
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
--------
F
L
--
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
--
L
M
T
-------
R
-------------
A
R
A
K
V
I
I
C
T
V
W
A
I
---
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
--
G
C
C
D
F
V
-
T
N
R
A
------------
Y
A
I
A
S
-
S
I
I
-
S
F
--
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
S
R
V
M
L
-----------
M
R
E
H
K
-----------
A
--------------------
L
K
T
L
G
I
I
M
G
V
----
F
T
L
C
W
L
P
----------
F
F
L
V
N
I
V
N
-------
V
F
N
R
D
L
V
P
------
D
W
---
L
----
F
V
--
A
F
--
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------------------------
30
HHSearch
58.48
16%
-154
- C6 -
3EML
8
ENLYS_BPT4
A:
[22-221]
----------------------------------------------------
S
V
Y
I
T
V
E
L
-
A
I
A
V
L
A
-
I
L
G
N
V
L
V
C
W
A
V
W
-----
L
N
S
N
L
Q
N
V
T
N
Y
F
V
--
V
S
L
A
A
A
D
I
A
V
G
---------
V
L
A
-
I
P
F
A
I
T
I
S
T
--
G
F
C
A
A
C
--------
H
G
--
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
--
L
V
T
-------
G
-------------
T
R
A
K
G
I
I
A
I
C
W
V
L
---
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
--
G
E
G
Q
----
V
A
C
------------
L
F
E
D
V
V
P
M
N
Y
M
V
--
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
Q
L
N
-----------
I
--------------------
F
E
M
L
R
I
D
E
G
L
----
R
L
K
I
Y
K
D
----------
T
E
G
Y
Y
T
I
G
-------
I
G
H
L
L
T
K
S
------
P
S
---
L
----
N
A
--
A
K
--
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
---------------
N
A
K
L
K
-------------
10
PsiBlast_PDB
58.36
25%
-123
- C6 -
2Y04
5
ADRB1_MELGA
A:
[5-126]
---------------------------------
L
L
S
--------
Q
Q
----
W
E
A
G
M
S
L
L
M
A
-
L
V
V
L
L
I
-
V
A
G
N
V
L
V
I
A
A
I
G
-----
S
T
Q
R
L
Q
T
L
T
N
L
F
I
--
T
S
L
A
C
A
D
L
V
V
G
---------
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
--------
F
L
--
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
--
L
M
T
-------
R
-------------
A
R
A
K
V
I
I
C
T
V
W
A
I
---
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
--
G
C
C
D
F
V
-
T
N
R
A
------------
Y
A
I
A
S
-
S
I
I
-
S
F
--
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
S
R
V
M
L
-----------
M
R
E
H
K
-----------
A
--------------------
L
K
T
L
G
I
I
M
G
V
----
F
T
L
C
W
L
P
----------
F
F
L
V
N
I
V
N
-------
V
F
N
R
D
L
V
P
------
D
W
---
L
----
F
V
--
A
F
--
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------------------------
9
PsiBlast_PDB
58.25
25%
-123
- C6 -
2Y03
3
ADRB1_MELGA
A:
[5-126]
---------------------------------
L
L
S
--------
Q
Q
----
W
E
A
G
M
S
L
L
M
A
-
L
V
V
L
L
I
-
V
A
G
N
V
L
V
I
A
A
I
G
-----
S
T
Q
R
L
Q
T
L
T
N
L
F
I
--
T
S
L
A
C
A
D
L
V
V
G
---------
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
--------
F
L
--
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
--
L
M
T
-------
R
-------------
A
R
A
K
V
I
I
C
T
V
W
A
I
---
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
--
G
C
C
D
F
V
-
T
N
R
A
------------
Y
A
I
A
S
-
S
I
I
-
S
F
--
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
S
R
V
-----------
M
L
M
R
E
-----------
H
--------------------
K
A
L
K
T
L
G
I
I
M
----
G
V
F
T
L
C
W
----------
L
P
F
F
L
V
N
I
-------
V
N
V
F
N
R
D
L
------
V
P
---
D
----
W
L
--
F
V
--
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------
4
PsiBlast_PDB
58.19
25%
-124
- C6 -
4BVN
8
ADRB1_MELGA
A:
[6-126]
----------------------------------
L
S
--------
Q
Q
----
W
E
A
G
M
S
L
L
M
A
-
L
V
V
L
L
I
-
V
A
G
N
V
L
V
I
A
A
I
G
-----
S
T
Q
R
L
Q
T
L
T
N
L
F
I
--
T
S
L
A
C
A
D
L
V
V
G
---------
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
--------
F
L
--
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
--
L
M
T
-------
R
-------------
A
R
A
K
V
I
I
C
T
V
W
A
I
---
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
--
G
C
C
D
F
V
-
T
N
R
A
------------
Y
A
I
A
S
-
S
I
I
-
S
F
--
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
R
K
-----------
T
S
R
V
M
-----------
L
--------------------
M
R
E
H
K
A
L
K
T
L
----
G
I
I
M
G
V
F
----------
T
L
C
W
L
P
F
F
-------
L
V
N
I
V
N
V
F
------
N
R
---
D
----
L
V
--
P
K
--
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
L
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------------------
14
PsiBlast_PDB
58.17
25%
-121
- C6 -
3ZPR
5
ADRB1_MELGA
A:
[5-126]
---------------------------------
L
L
S
--------
Q
Q
----
W
E
A
G
M
S
L
L
M
A
-
L
V
V
L
L
I
-
V
A
G
N
V
L
V
I
A
A
I
G
-----
S
T
Q
R
L
Q
T
L
T
N
L
F
I
--
T
S
L
A
C
A
D
L
V
V
G
---------
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
--------
F
L
--
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
--
L
M
T
-------
R
-------------
A
R
A
K
V
I
I
C
T
V
W
A
I
---
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
--
G
C
C
D
F
V
-
T
N
R
A
------------
Y
A
I
A
S
-
S
I
I
-
S
F
--
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
M
L
M
R
E
-----------
H
K
A
L
K
-----------
T
--------------------
L
G
I
I
M
G
V
F
T
L
----
C
W
L
P
F
F
L
----------
V
N
I
V
N
V
F
N
-------
R
D
L
V
P
D
W
L
------
F
V
---
A
----
F
N
--
W
L
--
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
--------------------------------------------