@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR1L3_HUMAN: (2016-01-12 )
MGMSNLTRLSEFILLGLSSRSEDQRPLFALFLIIYLVTLMGNLLIILAIHSDPRLQNPMYFFLSILSFADICYTTVIVPKMLVNFLSEKKTISYAECLAQMYFFLVFGNIDSYLLAAMAINRCVAICNPFHYVTVMNRRCCVLLLAFPITFSYFHSLLHVLLVNRLTFCTSNVIHHFFCDVNPVLKLSCSSTFVNEIVAMTEGLASVMAPFVCIIISYLRILIAVLKIPSAAGKHKAFSTCSSHLTVVILFYGSISYVYLQPLSSYTVKDRIATINYTVLTSVLNPFIYSLRNKDMKRGLQKLINKIKSQMSRFSTKTNKICGP
Atome Classification :
(20 SA)
.........10........---------------20.....----------------...30........40........50........60........70......-..80........90..--......100...----....110.......120.......130.......140.......150.......160.......170.......180--...-.-...----..-------190-----.........200.......210.......220..----.....230----.--------------------..--------.....240.......250------.........260....---.-..270.......280.......290.......300..--.....310.-------......320..-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MG
M
S
N
L
T
R
L
S
E
F
I
L
LGLSS---------------RSEDQ
R
P
----------------
L
F
A
L
F
L
I
I
Y
L
V
T
L
MG
N
L
L
I
I
L
A
IHSDPRLQ
N
P
M
Y
F
F
L
S
I
L
S
F
A
D
I
C
Y
T
T
V
I
-
V
P
K
M
L
V
N
F
L
SEKKT
I
S
--
Y
A
E
C
L
A
Q
M
Y
F
F
L
----VFGN
I
D
S
Y
L
L
A
A
M
A
I
N
R
C
V
A
I
CNP
F
H
Y
V
T
VMNR
R
C
C
V
L
L
L
A
F
P
I
T
F
S
Y
F
H
S
L
L
H
V
L
L
V
N
R
L
T
F
C
T
S
N
V
I
H
H
F
FCD----VN
P
-
V
-
L
K
L----SC-------
S
-------
S
T
F
V
N
E
I
V
A
M
T
E
G
L
A
S
V
M
A
P
F
V
C
I
I
I
S
Y
L
R
I
L
I
A
----
V
L
KIPS-A----A--------------------GK--------H
K
A
F
S
T
C
SS
H
L
T
V
V
I
L
--------
F
YG
S
I
S
Y
V
Y
L
QPLSSY---
T
-
V
KD
R
I
A
T
I
N
Y
T
V
L
T
S
V
L
N
P
F
I
Y
S
LR
N
K
D
M
K
R
G
L
Q
K
L
I
--
N
K
I
K
S
Q
M
S
R
-------FSTKTNKICGP-
16
PsiBlast_PDB
87.43
24%
-150
- C2 -
3ZPQ
11
ADRB1_MELGA
A:
[17-299]
------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
----
E
D
P
Q
A
-
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q-----------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
---
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
---
W
-
L
F
V
A
F
N
W
L
G
Y
A
--
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--
A
---------------------------
15
PsiBlast_PDB
87.34
24%
-153
- C2 -
4AMJ
12
ADRB1_MELGA
A:
[17-299]
------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
----
E
D
P
Q
A
-
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q-----------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
---
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
---
W
-
L
F
V
A
F
N
W
L
G
Y
A
--
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--
A
---------------------------
6
PsiBlast_PDB
87.28
24%
-151
- C2 -
2YCW
7
ADRB1_MELGA
A:
[17-297]
------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
----
E
D
P
Q
A
-
L
K
C
Y
Q
D
P
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
-
A
----
S
--------------------
K
R
KR
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
---
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
---
W
-
L
F
V
A
F
N
W
L
G
Y
A
--
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--
A
F
--------------------------
11
PsiBlast_PDB
86.43
24%
-151
- C2 -
2Y01
12
ADRB1_MELGA
A:
[17-299]
------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
----
E
D
P
Q
A
-
L
K
C
Y
Q
D
P
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q-----------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
---
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
---
W
-
L
F
V
A
F
N
W
L
G
Y
A
--
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--
A
---------------------------
10
PsiBlast_PDB
86.43
24%
-154
- C2 -
2Y00
13
ADRB1_MELGA
A:
[17-299]
------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
----
E
D
P
Q
A
-
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q-----------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
---
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
---
W
-
L
F
V
A
F
N
W
L
G
Y
A
--
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--
A
---------------------------
14
PsiBlast_PDB
86.21
24%
-155
- C2 -
2Y04
13
ADRB1_MELGA
A:
[17-299]
------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
----
E
D
P
Q
A
-
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
EQ-----------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
---
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
---
W
-
L
F
V
A
F
N
W
L
G
Y
A
--
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--
A
---------------------------
8
PsiBlast_PDB
85.73
24%
-152
- C2 -
2YCZ
2
ADRB1_MELGA
A:
[17-297]
------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
----
E
D
P
Q
A
-
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
-
A
----
S
--------------------
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
---
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
---
W
-
L
F
V
A
F
N
W
L
G
Y
A
--
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--
A
F
--------------------------
13
PsiBlast_PDB
85.47
24%
-154
- C2 -
2Y03
9
ADRB1_MELGA
A:
[17-299]
------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
----
E
D
P
Q
A
-
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
---------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
---
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
---
W
-
L
F
V
A
F
N
W
L
G
Y
A
--
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--
A
---------------------------
36
HHSearch
85.43
16%
-144
- C2 -
2Z73
5
OPSD_TODPA
A:
[31-334]
-----------------------------------
D
A
V
Y
Y
S
----------------
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
--
F
A
A
C
K
V
Y
G
F
I
G
G
----
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
----
E
G
V
L
C
N
C
S
----
F
D
Y
-
I
-
S
-----------------------
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
----
V
S
N
H
E
K
-
E
----
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
--------
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
--------
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
LEW
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
--
P
W
V
L
T
C
C
Q
F
-------
D
D
K
E
T
E
D
D
K
D
A
-
12
PsiBlast_PDB
85.23
24%
-154
- C2 -
2Y02
13
ADRB1_MELGA
A:
[17-299]
------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
----
E
D
P
Q
A
-
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q-----------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
---
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
---
W
-
L
F
V
A
F
N
W
L
G
Y
A
--
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--
A
---------------------------
7
PsiBlast_PDB
84.68
24%
-151
- C2 -
2YCX
3
ADRB1_MELGA
A:
[17-294]
------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
----
E
D
P
Q
A
-
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
-
A
----
S
--------------------
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
---
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
---
W
-
L
F
V
A
F
N
W
L
G
Y
A
--
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
---------------------------------
9
PsiBlast_PDB
84.53
24%
-149
- C2 -
2YCY
6
ADRB1_MELGA
A:
[17-297]
------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
----
E
D
P
Q
A
-
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
--
D
R
-
A
----
S
--------------------
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
---
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
---
W
-
L
F
V
A
F
N
W
L
G
Y
A
--
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--
A
F
--------------------------
43
Fugue
84.26
18%
-118
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
---------------
T
G
V
V
R
S
P
FEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
--
P
T
G
C
N
L
E
G
F
F
A
T
----
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
----------------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
----
Y
I
P
-
E
G
M
Q
C
----
S
C
-------
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
E
A
A
A
-
S
----
A
--------------------
T
T
--------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
---
G
-
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
S
T
T
-------
V
S
K
T
E
T
S
Q
V
A
P
A
5
PsiBlast_PDB
83.34
24%
-151
- C2 -
2VT4
8
ADRB1_MELGA
A:
[17-297]
------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
----
E
D
P
Q
A
-
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
---------------------------------
E
-------
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
---
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
---
W
-
L
F
V
A
F
N
W
L
G
Y
A
--
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--
A
---------------------------
1
PsiBlast_PDB
80.71
23%
-146
- C2 -
4GBR
1
ADRB2_HUMAN
A:
[14-286]
---------------------------------------------------------------
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
----
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
------------
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
-
Y
-
A
E
E
----
T
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
----
A
K
R
Q
L
Q
-
K
----
I
--------------------
D
K
FC
L
K
E
---
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
---
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
---
E
-
V
Y
I
L
L
N
W
I
G
Y
--
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
CL----------------------------
17
PsiBlast_PDB
80.03
24%
-138
- C2 -
4QKX
2
ADRB2_HUMAN
A:
[191-461]
---------------------------------------------------------------
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
----
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
------------
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
-
Y
-
A
E
E
----
T
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
---
K
F
A
----
L
--------------------
K
E
--------
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
---
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
---
E
-
V
Y
I
L
L
N
W
I
G
Y
--
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
--
C
L
--------------------------
2
PsiBlast_PDB
79.39
24%
-135
- C2 -
4LDE
3
A:
[191-461]
---------------------------------------------------------------
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
----
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
------------
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
-
Y
-
A
E
E
----
T
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
---
K
F
A
----
L
--------------------
K
E
--------
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
---
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
---
E
-
V
Y
I
L
L
N
W
I
G
Y
--
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
--
C
L
--------------------------
4
PsiBlast_PDB
79.28
24%
-136
- C2 -
4LDO
3
A:
[191-461]
---------------------------------------------------------------
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
----
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
------------
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
-
Y
-
A
E
E
----
T
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
---
K
F
A
----
L
--------------------
K
E
--------
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
---
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
---
E
-
V
Y
I
L
L
N
W
I
G
Y
--
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
--
C
L
--------------------------
3
PsiBlast_PDB
79.24
24%
-137
- C2 -
4LDL
3
ADRB2_HUMAN
A:
[191-461]
---------------------------------------------------------------
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
----
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
------------
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
-
Y
-
A
E
E
----
T
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
---
K
F
A
----
L
--------------------
K
E
--------
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
---
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
---
E
-
V
Y
I
L
L
N
W
I
G
Y
--
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
--
C
L
--------------------------
44
Fugue
72.84
16%
-114
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
--
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
GVVRSPFEAPQYYLA
E
P
W
Q
F
S
M
----------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
--
P
T
G
C
N
L
E
G
F
F
A
T
----
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
----------------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
----
Y
I
P
-
E
G
M
Q
C
----
S
C
G
I
DYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
E
A
A
A
-
Q
QQES
A
--------------------
T
T
--------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
---
G
-
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
L
G
D
DEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-