@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2V1_HUMAN: (2016-01-13 )
MGRWVNQSYTDGFFLLGIFSHSQTDLVLFSAVMVVFTVALCGNVLLIFLIYLDAGLHTPMYFFLSQLSLMDLMLVCNIVPKMAANFLSGRKSISFVGCGIQIGFFVSLVGSEGLLLGLMAYDRYVAVSHPLHYPILMNQRVCLQITGSSWAFGIIDGVIQMVAAMGLPYCGSRSVDHFFCEVQALLKLACADTSLFDTLLFACCVFMLLLPFSIIMASYACILGAVLRIRSAQAWKKALATCSSHLTAVTLFYGAAMFMYLRPRRYRAPSHDKVASIFYTVLTPMLNPLIYSLRNGEVMGALRKGLDRCRIGSQH
Atome Classification :
(20 SA)
----------------------------------------------------------.....-----------....10----.........20.....-------...30........-40....---....50........60........70.......-.80--.........90........100.......110...-....120.......130----....-----....140.......150....-------------...160.......170.....-----------..180------........190.-------........200--------....-.....---------------210.......220....-----------..------------.-------230--------------------.--------......240......----.250-------.......260..--.------.---.---.-.-270.--.--.....-.280.......---------..290.....-..300....--...310...---------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------MGRWV-----------NQSYT-----D
G
F
F
L
L
G
I
FSHSQ
T
D
L
-------
V
L
F
S
A
V
M
V
V
F
T
V
A
-
L
C
G
N
V
L
---
L
I
F
L
I
Y
L
DAGLH
T
P
M
Y
F
F
L
S
Q
L
S
L
M
D
L
M
L
V
C
N
I
-
V
P
---
K
M
A
A
N
F
LSGR
K
S
I
S
F
V
G
C
G
I
Q
I
G
F
F
V
S
LVGSE
G
L
L
-
L
G
L
M
AYD
R
Y
V
AVSHPL-----HY
P
I
-----LMN
Q
R
V
C
L
Q
I
TGSS
W
A
F
G
I
I
D
-------------
G
V
I
Q
M
V
A
A
MGLPYCGSR
S
V
D
H
-----------
F
F
C
E
-------
V
Q
A
L
L
K
L
AC--A-------D
T
S
L
F
D
T
L
L
----------
F
A
C
C
-
V
F
M
L
L
---------------
L
P
F
S
I
I
M
A
S
Y
A
C
I
L
G
A
V
-----------
L
R
------------
I
-------
R
S
A
--------------------
Q
--------
A
W
K
K
A
L
A
T
C
S
S
H
L
T
A
----
V
T
L
F
-------
Y
G
A
A
M
F
M
YLRPR--R------Y---R---A-P-
S
-
H
D
--
K
--
V
A
S
I
F
-
Y
T
--
V
L
T
P
M
L
N
---------
P
L
I
Y
SLRN
G
E
-
V
M
G
A
L
R
K
G
L
--
D
RCRIGSQH---------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
91.49
21%
-154
- C4 -
2YDO
3
?
A:
[8-301]
-----------------------------------------------------------------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
-
I
L
G
N
V
L
---
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
T
A
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-----
R
Y
N
G
-----
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
-------------
G
L
T
P
M
---
L
G
W
N
N
C
G
Q
P
K
E
G
K
-----------
A
H
S
Q
-------
G
C
G
E
G
Q
V
A
C
-------------
L
F
E
D
V
V
P
M
N
Y
M
V
YF
N
F
F
A
C
-----
V
L
---------------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
Q
L
K
Q
M
E
S---------------------------------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
----
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
------
S
---
H
---
A
-
P
-
L
-
W
L
--
M
--
Y
L
A
I
V
-
L
S
--
H
T
N
S
V
V
N
---------
P
F
I
Y
A
Y
R
I
R
E
-
F
R
Q
T
F
R
K
I
I
--
R
S
H
V
L
R
Q
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
89.92
21%
-155
- C4 -
3VGA
1
AA2AR_HUMAN
A:
[8-301]
-----------------------------------------------------------------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
-
I
L
G
N
V
L
---
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
T
Q
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-----
R
Y
N
G
-----
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
-------------
G
L
T
P
M
---
L
G
W
N
N
C
G
Q
------------------
S
Q
-------
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
YFNF------
F
A
C
-----
V
L
---------------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
Q
L
K
Q
M
E
S
Q
PLPG
E
-------
R
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
----
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
------
S
---
H
---
A
-
P
-
L
-
W
L
--
M
--
Y
L
A
I
V
-
L
S
--
H
T
N
S
V
V
N
---------
P
F
I
Y
A
Y
R
I
R
E
-
F
R
Q
T
F
R
K
I
I
--
R
S
H
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
89.84
21%
-156
- C4 -
3VG9
8
?
A:
[8-301]
-----------------------------------------------------------------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
-
I
L
G
N
V
L
---
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
T
Q
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-----
R
Y
N
G
-----
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
-------------
G
L
T
P
M
---
L
G
W
N
N
C
G
Q
------------------
S
Q
-------
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
YFNF------
F
A
C
-----
V
L
---------------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
Q
L
K
Q
M
E
S
Q
PLPG
E
-------
R
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
----
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
------
S
---
H
---
A
-
P
-
L
-
W
L
--
M
--
Y
L
A
I
V
-
L
S
--
H
T
N
S
V
V
N
---------
P
F
I
Y
A
Y
R
I
R
E
-
F
R
Q
T
F
R
K
I
I
--
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
89.11
21%
-153
- C4 -
2YDV
6
?
A:
[8-301]
-----------------------------------------------------------------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
-
I
L
G
N
V
L
---
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
T
A
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-----
R
Y
N
G
-----
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
-------------
G
L
T
P
M
---
L
G
W
N
N
C
G
Q
P
K
E
G
K
-----------
A
H
S
Q
-------
G
C
G
E
G
Q
V
A
C
-------------
L
F
E
D
V
V
P
M
N
Y
M
V
YF
N
F
F
A
C
-----
V
L
---------------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
Q
L
K
Q
M
ESQ-----------------------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
----
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
------
S
---
H
---
A
-
P
-
L
-
W
L
--
M
--
Y
L
A
I
V
-
L
S
--
H
T
N
S
V
V
N
---------
P
F
I
Y
A
Y
R
I
R
E
-
F
R
Q
T
F
R
K
I
I
--
R
S
H
V
L
R
Q
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
86.46
21%
-159
- C4 -
3REY
1
AA2AR_HUMAN
A:
[8-301]
-----------------------------------------------------------------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
-
I
L
G
N
V
L
---
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
A
Q
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-----
R
Y
N
G
-----
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
-------------
G
L
T
P
M
---
L
G
W
N
N
C
G
Q
P
--------------------------
G
C
G
E
G
Q
V
A
C
-------------
L
F
E
D
V
V
P
M
N
Y
M
V
YFNF
F
A
C
-----
V
L
---------------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----------
R
R
Q
L
K
Q
M
E
S
QPLPG
E
-------
R
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
----
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
------
S
---
H
---
A
-
P
-
L
-
W
L
--
M
--
Y
L
A
I
V
-
L
A
--
H
T
N
S
V
V
N
---------
P
F
I
Y
A
Y
R
I
R
E
-
F
R
Q
T
F
R
K
I
I
--
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
86.30
21%
-155
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[8-301]
-----------------------------------------------------------------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
-
I
L
G
N
V
L
---
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
A
Q
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-----
R
Y
N
G
-----
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
-------------
G
L
T
P
M
---
L
G
W
N
N
C
G
Q
P
--------------------------
G
C
G
E
G
Q
V
A
C
-------------
L
F
E
D
V
V
P
M
N
Y
M
V
YFNF
F
A
C
-----
V
L
---------------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----------
R
R
Q
L
K
Q
M
E
S
QPLPG
E
-------
R
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
----
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
------
S
---
H
---
A
-
P
-
L
-
W
L
--
M
--
Y
L
A
I
V
-
L
A
--
H
T
N
S
V
V
N
---------
P
F
I
Y
A
Y
R
I
R
E
-
F
R
Q
T
F
R
K
I
I
--
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
86.12
18%
-140
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
----------------------------------------------------------
M
N
G
T
E
-----------
G
P
N
F
Y
VPFSN
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
AE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
-
F
P
I
N
F
L
---
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
-
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-----
S
N
--------------
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-------------
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
---
W
S
R
-----------
Y
I
P
E
----------
G
M
Q
C
S
C
--
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
----------
I
Y
M
F
-
V
V
H
F
I
---------------
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-----------
K
E
------------
A
AASATTQ
K
A
E
--------------------
K
--------
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
----
C
W
L
P
-------
Y
A
G
V
A
F
Y
I
F
T
H
Q
--
G
------
S
---
D
---
F
-
G
-
P
-
I
F
--
M
--
T
I
P
A
F
-
F
A
--
K
T
S
A
V
Y
N
---------
P
V
I
Y
I
M
M
N
K
Q
-
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
86.01
21%
-159
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[8-301]
-----------------------------------------------------------------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
-
I
L
G
N
V
L
---
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
A
Q
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-----
R
Y
N
G
-----
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
-------------
G
L
T
P
M
---
L
G
W
N
N
C
G
Q
P
--------------------------
G
C
G
E
G
Q
V
A
C
-------------
L
F
E
D
V
V
P
M
N
Y
M
V
YFNF
F
A
C
-----
V
L
---------------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----------
R
R
Q
L
K
Q
M
E
S
QPLPG
E
-------
R
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
----
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
------
S
---
H
---
A
-
P
-
L
-
W
L
--
M
--
Y
L
A
I
V
-
L
A
--
H
T
N
S
V
V
N
---------
P
F
I
Y
A
Y
R
I
R
E
-
F
R
Q
T
F
R
K
I
I
--
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
85.98
21%
-155
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[8-301]
-----------------------------------------------------------------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
-
I
L
G
N
V
L
---
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
A
Q
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-----
R
Y
N
G
-----
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
-------------
G
L
T
P
M
---
L
G
W
N
N
C
G
Q
P
--------------------------
G
C
G
E
G
Q
V
A
C
-------------
L
F
E
D
V
V
P
M
N
Y
M
V
YFNF
F
A
C
-----
V
L
---------------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----------
R
R
Q
L
K
Q
M
E
S
QPLPG
E
-------
R
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
----
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
------
S
---
H
---
A
-
P
-
L
-
W
L
--
M
--
Y
L
A
I
V
-
L
A
--
H
T
N
S
V
V
N
---------
P
F
I
Y
A
Y
R
I
R
E
-
F
R
Q
T
F
R
K
I
I
--
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
85.70
21%
-159
- C4 -
3PWH
1
?
A:
[8-301]
-----------------------------------------------------------------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
-
I
L
G
N
V
L
---
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
A
Q
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-----
R
Y
N
G
-----
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
-------------
G
L
T
P
M
---
L
G
W
N
N
C
G
Q
P
--------------------------
G
C
G
E
G
Q
V
A
C
-------------
L
F
E
D
V
V
P
M
N
Y
M
V
YFNF
F
A
C
-----
V
L
---------------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----------
R
R
Q
L
K
Q
M
E
S
QPLPG
E
-------
R
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
----
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
------
S
---
H
---
A
-
P
-
L
-
W
L
--
M
--
Y
L
A
I
V
-
L
A
--
H
T
N
S
V
V
N
---------
P
F
I
Y
A
Y
R
I
R
E
-
F
R
Q
T
F
R
K
I
I
--
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
81.53
18%
-119
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----------------------------------------------------MN
G
T
E
G
P
N
F
Y
V
-----------
P
F
S
N
K
-----
T
G
V
-
V
R
S
P
F
E
A
P
Q
Y
Y
L
AE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
-
F
P
I
N
F
L
---
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
-
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-----
S
N
--------------
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-------------
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
---
W
S
R
-----------
Y
I
P
E
----------
G
M
Q
C
S
C
--
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
----------
I
Y
M
F
-
V
V
H
F
I
---------------
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
KEAAAQQQESA
T
T
------------
Q
-------
K
A
E
--------------------
K
--------
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
----
C
W
L
P
-------
Y
A
G
V
A
F
Y
I
F
T
H
Q
--
G
------
S
---
D
---
F
-
G
-
P
-
I
F
--
M
--
T
I
P
A
F
-
F
A
--
K
T
S
A
V
Y
N
---------
P
V
I
Y
I
M
M
N
K
Q
-
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA-----------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
80.24
14%
-146
- C4 -
2Z73
5
OPSD_TODPA
A:
[33-333]
-------------------------------------------------------------------------------------------------
V
Y
Y
-------
S
L
G
I
F
I
G
I
C
G
I
I
G
-
C
G
G
N
G
I
---
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
---
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
-
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
-----
A
A
S
K
-----
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
-------------
A
I
G
P
I
F
G
--
W
-
G
A
Y
T
-
L
E
G
V
L
-----------
C
N
C
S
-------
F
D
Y
I
S
--------------
R
D
S
T
T
R
S
N
I
----------
L
C
M
F
-
I
L
G
F
F
---------------
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
-----------
S
N
------------
H
-------
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
--------
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
----
F
L
L
S
-------
W
S
P
Y
A
V
V
A
L
L
A
Q
--
F
------
G
---
P
LEW
V
-
T
-
P
-
Y
A
--
A
--
Q
L
P
V
M
-
F
A
--
K
A
S
A
I
H
N
---------
P
M
I
Y
S
V
S
H
P
K
-
F
R
E
A
I
S
Q
T
F
--
P
W
V
L
T
C
C
Q
F
---------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
77.33
15%
-137
- C4 -
2KS9
1
NK1R_HUMAN
A:
[36-326]
-------------------------------------------------------------------------------------------------------------
A
A
A
Y
T
V
I
V
V
T
S
-
V
V
G
N
V
V
---
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
---
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
-
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
-----
Q
P
R
L
-------
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
-------------
A
F
P
Q
G
Y
--
Y
S
-
T
T
-
E
-
T
M
P
S
R
-----------
V
V
C
M
-------
I
E
W
P
E
H
P
------------
N
K
I
Y
E
K
V
Y
H
----------
I
C
V
T
-
V
L
I
Y
F
---------------
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
-----------
W
A
------------
S
-------
E
I
P
GDSSDRYH
E
Q
V
---------
S
--------
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
----
F
A
I
C
-------
W
L
P
F
H
I
F
F
L
L
P
Y
--
I
------
N
PD-
L
---
Y
L
K
-
K
F
I
Q
Q
V
Y
--
L
A
I
M
W
-
L
A
--
M
S
S
T
M
Y
N
---------
P
I
I
Y
C
C
L
N
D
R
-
F
R
L
G
F
K
H
A
F
--
R
C
C
P
F
I
S
A
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
72.86
21%
-136
- C1 -
4UOX
9
PAT_ECOLI
A:
[7-459]
SAS
A
L
A
C
S
A
H
A
L
N
L
I
E
KRTLD
H
E
E
M
K
A
L
N
R
E
V
I
E
Y
F
K
E
HVN
P
G
F
L
E
Y
R
K
S
V
TAGGDYG
A
V
E
W
Q
AGSLN
T
L
V
D
TQ
G
Q
E
F
I
-----
D
C
L
G
G
F
G
I
F
N
V
G
H
R
N
P
-------
V
V
V
S
A
V
Q
N
Q
L
A
K
Q
P
L
H
S
Q
E
L
LD
P
L
R
A
M
L
A
K
T
L
A
A
L
T
P
G
K
L
K
Y
S
F
F
C
N
-
S
G
T
E
S
V
E
A
-
A
L
---
K
L
A
K
A
Y
Q
S
P
R
G
K
F
T
F
I
A
T
S
---
G
A
F
H
---
G
K
S
L
G
A
-
L
S
A
T
A
K
S
T
F
R
K
P
F
M
P
L
LPG
F
R
H
V
P
F
GN
I
E
A
M
R
T
A
L
N
E
C
K
K
T
G
D
D
V
A
A
V
I
L
E
PIQGEGGVILPPP
G
Y
L
T
A
V
R
K
L
C
D
E
F
G
A
L
M
I
L
D
E
VQTGMGRTGKM
F
A
C
E
HENVQPD
I
L
C
L
A
K
A
L
G
--
G
-------
G
V
M
P
I
G
A
T
I
----------
A
T
E
E
-
V
F
S
V
L
FDNPFL
H
T
T
T
FGGN
P
L
A
C
A
A
A
L
A
T
I
N
V
L
L
E
Q
N
-----------
L
P
------------
A
-------
Q
A
E
--------------------
Q
--------
K
G
D
M
L
L
D
G
F
R
Q
L
A
R
E
Y
PDL
V
Q
E
A
-------
R
G
K
G
M
L
M
A
I
E
F
V
--
D
----------
N
---
E
-
I
-
G
-
Y
N
--
F
--
A
S
E
M
F
-
R
Q
R
V
L
V
A
G
T
L
N
NA
K
T
I
R
IEP
P
L
T
L
T
I
E
Q
C
E
L
V
I
K
A
A
R
K
A
L
--
A
A
M
R
V
S
V
E
E
A--------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
71.92
15%
-123
- C4 -
1U19
14
OPSD_BOVIN
A:
[43-328]
------------------------------------------------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
-
F
P
I
N
F
L
---
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
-
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-----
S
N
F
R
------
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
-------------
A
A
P
P
L
V
G
-
W
--
S
R
Y
I
-
P
E
G
M
Q
-----------
C
S
C
G
-------
I
D
Y
Y
T
P
-----
H
-------
E
E
T
N
N
E
S
F
V
----------
I
Y
M
F
-
V
V
H
F
I
---------------
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-----------
K
E
------------
A
-------
A
A
Q
--------------------
Q
QESA
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
----
F
L
I
C
-------
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
------
G
S--
D
---
F
-
G
-
P
-
I
F
--
M
--
T
I
P
A
F
-
F
A
--
K
T
S
A
V
Y
N
---------
P
V
I
Y
I
M
M
N
K
Q
-
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
L
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
71.25
17%
-126
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
-------------------------------------------------------------------------------------------------
N
K
Y
-------
V
V
I
I
A
Y
A
L
V
F
L
L
S
-
L
L
G
N
S
L
---
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
---
I
W
A
A
S
K
-
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
-
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
-----
R
T
L
T
------
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
-------------
S
L
P
F
F
L
F
--
R
-
Q
A
Y
H
-
P
N
N
S
S
-----------
P
V
C
Y
-------
E
V
L
G
N
D
-------------
T
A
K
W
R
M
V
L
R
----------
I
L
P
H
-
T
F
G
F
I
---------------
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
-----------
F
K
------------
A
-------
H
-
M
--------------------
G
--------
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
----
F
L
L
C
-------
W
L
P
Y
N
L
V
L
L
A
D
T
--
L
M
RTQVI
Q
E
S
C
E
---
R
-
R
N
N
-
I
G
--
R
A
L
D
A
T
E
I
-
L
G
--
F
L
H
S
C
L
N
---------
P
I
I
Y
A
F
I
G
Q
N
-
F
R
H
G
F
L
K
I
L
--
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
69.68
14%
-121
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
----------------------------------------------------------------------------------------------
D
E
V
W
V
V
-------
G
M
G
I
V
M
S
L
I
V
L
A
I
-
V
F
G
N
V
L
---
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
---
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
-
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-----
K
Y
Q
S
-----
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
-------------
S
F
L
P
I
Q
M
-------
H
W
Y
R
A
T
H
-----------
Q
E
A
I
-------
N
C
Y
A
E
E
T
C
C
--
D
-------
F
F
T
N
Q
A
Y
A
I
----------
A
S
S
I
-
V
S
F
Y
V
---------------
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
-----------
R
Q
------------
L
-------
N
I
F
--------------------
E
--------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
----
T
E
G
Y
-------
Y
T
I
G
I
G
H
L
L
T
K
S
--
P
------
S
---
L
---
N
-
A
-
A
-
K
S
--
E
--
L
D
K
A
I
G
R
N
--
T
N
G
V
I
T
K
---------
D
E
A
E
K
L
F
N
Q
D
-
V
D
A
A
V
R
G
I
L
--
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
2
PsiBlast_PDB
68.06
22%
-148
- C4 -
4DKL
11
ENLYS_BPT4 (first)
A:
[16-212]
-------------------------------------------------------------------------------------------------
T
A
I
-------
T
I
M
A
L
Y
S
I
V
C
V
V
G
-
L
F
G
N
F
L
---
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
A
L
A
T
S
T
-
L
P
---
F
Q
S
V
N
Y
L
M
G
T
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
-
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
-----
K
A
L
D
-----
F
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
----------------------
S
A
I
G
L
P
V
M
F
M
A
T
T
K
Y
-----------
R
Q
G
S
-------
I
D
C
T
L
T
F
S
---
H
-------
P
T
W
Y
W
E
N
L
L
----------
K
I
C
V
F
I
F
A
F
I
---------------
M
P
V
L
I
I
T
V
C
Y
G
L
M
---
I
-----------
L
R
------------
L
-------
K
S
V
--------------------
R
--------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
----
I
Y
K
N
-------
T
E
G
Y
Y
T
I
G
I
G
H
L
--
L
------
T
---
K
---
S
-
P
-
S
-
L
N
--
A
--
A
K
S
E
L
-
D
K
--
A
I
G
R
N
T
N
---------
G
V
I
T
K
D
E
A
E
K
-
L
F
N
Q
D
V
D
A
A
--
V
R
G
I
L
R
N
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
67.24
20%
-145
- C4 -
2RH1
6
ADRB2_HUMAN (first)
A:
[39-235]
-------------------------------------------------------------------------------------------------
W
V
V
-------
G
M
G
I
V
M
S
L
I
V
L
A
I
-
V
F
G
N
V
L
---
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
---
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
-
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-----
K
Y
Q
S
-----
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
-------------
S
F
L
P
I
Q
M
H
W
Y
--
R
-
A
-
T
H
Q
E
A
-----------
I
N
C
Y
-------
A
E
----
E
T
C
--
C
-------
D
F
F
T
N
Q
A
Y
A
----------
I
A
S
S
-
I
V
S
F
Y
---------------
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
-----------
K
R
------------
Q
-------
L
N
I
--------------------
F
--------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
----
D
T
E
G
-------
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
------
P
---
S
---
L
-
N
-
A
-
A
K
--
S
--
E
L
D
K
A
-
I
G
--
R
N
T
N
G
V
I
---------
T
K
D
E
A
E
K
L
F
N
-
Q
D
V
D
A
A
V
R
G
--
I
L
R
N
A
K
L
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
65.93
24%
-139
- C4 -
5C1M
5
?
A:
[19-212]
-------------------------------------------------------------------------------------------------
T
I
M
-------
A
L
Y
S
I
V
C
V
V
---
G
-
L
F
G
N
F
L
---
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
A
L
A
T
S
T
-
L
P
---
F
Q
S
V
N
Y
L
M
G
T
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
-
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
-----
K
A
L
D
-----
F
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
----------------------
S
A
I
G
L
P
V
M
F
M
A
T
T
K
Y
-----------
R
Q
G
S
-------
I
D
C
T
L
T
F
S
---
H
-------
P
T
W
Y
W
E
N
L
L
----------
K
I
C
V
F
I
F
A
F
I
---------------
M
P
V
L
I
I
T
V
C
Y
G
L
M
---
I
-----------
L
R
------------
L
-------
K
S
V
--------------------
R
--------
M
L
S
G
S
K
E
K
D
R
N
L
R
R
I
----
T
R
M
V
-------
L
V
V
V
A
V
F
I
V
C
W
T
--
P
------
I
---
H
---
I
-
Y
-
V
-
I
I
--
K
--
A
L
I
T
I
-
P
E
--
T
T
F
Q
T
V
S
---------
W
H
F
C
I
A
L
G
Y
T
-
N
S
C
L
N
P
V
L
Y
--
A
F
L
D
E
N
F
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------