@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR6B2_HUMAN: (2016-01-13 )
MSGENVTKVSTFILVGLPTAPGLQYLLFLLFLLTYLFVLVENLAIILIVWSSTSLHRPMYYFLSSMSFLEIWYVSDITPKMLEGFLLQQKRISFVGCMTQLYFFSSLVCTECVLLASMAYDRYVAICHPLRYHVLVTPGLCLQLVGFSFVSGFTISMIKVCFISSVTFCGSNVLNHFFCDISPILKLACTDFSTAELVDFILAFIILVFPLLATILSYWHITLAVLRIPSATGCWRAFSTCASHLTVVTVFYTALLFMYVRPQAIDSQSSNKLISAVYTVVTPIINPLIYCLRNKEFKDALKKALGLGQTSH
Atome Classification :
(20 SA)
-----------------....--------------..-...10......-----.--------.---20.....----------...-------30....-----..-..40----------.........50.....-..--.60......-----.--.70......-..---80.....-..---------.90......----..100..-.....110..-----.....120.......130.-----------------..---....140.......---------150....-.-..160-...------------.----------...170.......180--....------.....--------190------..-----.......200.......210..--.....220--.....-----..---------.-------.-----230----------.--------------------...---....240....--------------.-------...-----.250....-------...260------...-------.------------.---.---..--270-...------.....------.280-.-......290....-...300....-...310-----------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------MSGE--------------N
V
-
T
K
V
S
T
F
I
L
V
GL-----P--------T---AP
G
L
Q
Y
L
----------
L
F
L
-------
L
F
L
L
T
Y
-----
L
F
-
V
L
V
-----------EN
L
A
I
I
L
I
V
WSSTSLH-
R
P
--
M
Y
Y
F
L
S
SM
S
-----
F
--
L
E
I
W
Y
VSDI-
T
P
---
K
M
L
E
G
F
L
-
L
Q
---------
Q
K
R
I
S
F
V
G
C
----
M
T
Q
L
Y
F
F
-
S
S
L
V
C
T
E
C
V
L
-----
L
A
S
M
A
YD
R
Y
V
A
ICH
P
L
R
Y
H
-----------------
V
L
---VT
P
G
L
C
L
Q
L
V
G
F
S
F
---------VS
G
F
T
I
S
-
M
-
I
K
V
C
F
-IS
S
------------
V
----------
T
F
C
G
S
N
V
L
N
H
F
F
C
D
----
I
S
P
I
------
L
K
L
AC--------T--------DF-----
S
T
A
E
L
V
D
F
I
L
A
F
I
I
L
V
F
P
L
L
A
T
--
I
L
S
Y
W
H
----
I
T
L
A
V
-----
L
R---------I-------P-----SA-----------T--------------------
G
C
W
---
R
A
F
S
T
--
C
A
S
H
--------------
L
-------
T
V
V
-----
T
V
F
Y
T
A
L
L
-------
F
M
YV-R------PQA-------I------------D---S---QS--S---
N
K
L
------
I
S
A
V
Y
------
T
V
V
T
-
P
-
I
I
N
P
L
I
Y
C
LRN
K
E
-
F
K
D
A
L
K
K
A
LG-LGQTSH-----------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
87.77
18%
-142
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----------------
M
N
G
T
E
G
PNF---------
Y
V
-
P
F
S
N
K
T
G
V
V
R
S
-----
P
--------
F
---
E
A
P
Q
Y
Y
L
AE
P
W
Q
F
S
M
--
L
A
A
-------
Y
M
F
L
L
I
-----
M
L
-
G
F
P
-----------
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
-
T
P
--
L
N
Y
I
L
L
N
L
A
-----
V
--
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
T
S
L
-
H
G
---------
Y
F
V
F
G
P
T
G
C
----
N
L
E
G
F
F
A
-
T
L
G
G
E
I
A
L
W
S
-----
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
----------------------------------
N
F
R
F
---------
G
E
N
H
A
I
M
-
G
-
V
A
F
T
W
-
V
M
A
------------
L
----------
A
C
A
-
A
P
P
L
V
G
W
S
R
Y
----
I
P
E
G
------
M
Q
C
S
C
--------
G
I
DYYTPHE
E
T
-----
N
N
E
S
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
V
I
--
F
F
C
Y
G
Q
----
L
V
F
T
V
-----
K
E
---------
A
AASATTQ
K
-----
A
E
-----------
K
--------------------
E
V
T
---
R
M
V
I
I
--
M
V
I
A
--------------
F
-------
L
I
C
-----
W
L
P
Y
A
G
V
A
-------
F
Y
I
F
-
T
------
H
Q
G
-------
S
------------
D
---
F
---
G
P
--
I
---
F
M
T
------
I
P
A
F
F
------
A
K
T
S
-
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
-
F
R
N
C
M
V
T
T
L
C
-
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
86.59
21%
-153
- C3 -
2YDO
3
?
A:
[18-301]
---------------------------------------------------------------------------------------------------------
V
L
-
A
I
L
-----------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
-
N
V
--
T
N
Y
F
V
V
S
A
A
-----
A
--
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
-
A
A
---------
C
H
G
C
L
F
I
A
C
----
F
V
L
V
L
T
A
-
S
S
I
F
S
----------
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
-----------------
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------
V
L
S
F
A
I
G
-
L
-
T
P
M
L
G
-
W
N
N
------------
C
GQPK
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
----
V
V
P
M
------
N
Y
M
V
Y
--------
F
--------
N
F
----------------
F
A
C
V
L
V
P
L
L
L
M
--
L
G
V
Y
L
R
----
I
F
L
A
A
-----
R
R
Q
L
K
Q
M
E
S------------------------------------------------------------
T
--
L
Q
K
E
--------------
V
H
A
A
K
S
L
A
I
I
V
-----
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
------
P
D
C
-------
S
------------
H
---
A
---
P
L
--
W
---
L
M
Y
------
L
A
I
V
L
------
S
H
T
N
-
S
-
V
V
N
P
F
I
Y
A
Y
R
I
R
E
-
F
R
Q
T
F
R
K
I
I
R
-
S
H
V
L
R
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
85.77
21%
-153
- C3 -
2YDV
6
?
A:
[18-301]
---------------------------------------------------------------------------------------------------------
V
L
-
A
I
L
-----------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
-
N
V
--
T
N
Y
F
V
V
S
A
A
-----
A
--
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
-
A
A
---------
C
H
G
C
L
F
I
A
C
----
F
V
L
V
L
T
A
-
S
S
I
F
S
----------
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
-----------------
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------
V
L
S
F
A
I
G
-
L
-
T
P
M
L
G
-
W
N
N
------------
C
GQPK
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
----
V
V
P
M
------
N
Y
M
V
Y
--------
F
--------
N
F
----------------
F
A
C
V
L
V
P
L
L
L
M
--
L
G
V
Y
L
R
----
I
F
L
A
A
-----
R
R
Q
L
K
Q
M
ESQ----------------------------------------------------------
S
T
--
L
Q
K
E
--------------
V
H
A
A
K
S
L
A
I
I
V
-----
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
------
P
D
C
-------
S
------------
H
---
A
---
P
L
--
W
---
L
M
Y
------
L
A
I
V
L
------
S
H
T
N
-
S
-
V
V
N
P
F
I
Y
A
Y
R
I
R
E
-
F
R
Q
T
F
R
K
I
I
R
-
S
H
V
L
R
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
85.48
21%
-151
- C3 -
4UG2
3
?
A:
[18-301]
---------------------------------------------------------------------------------------------------------
V
L
-
A
I
L
-----------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
-
N
V
--
T
N
Y
F
V
V
S
A
A
-----
A
--
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
-
A
A
---------
C
H
G
C
L
F
I
A
C
----
F
V
L
V
L
T
A
-
S
S
I
F
S
----------
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
-----------------
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------
V
L
S
F
A
I
G
-
L
-
T
P
M
L
G
-
W
N
N
------------
C
GQPK
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
----
V
V
P
M
------
N
Y
M
V
Y
--------
F
--------
N
F
----------------
F
A
C
V
L
V
P
L
L
L
M
--
L
G
V
Y
L
R
----
I
F
L
A
A
-----
R
R
Q
L--------------------------------------------------------------
A
R
S
T
--
L
Q
K
E
--------------
V
H
A
A
K
S
L
A
I
I
V
-----
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
------
P
D
C
-------
S
------------
H
---
A
---
P
L
--
W
---
L
M
Y
------
L
A
I
V
L
------
S
H
T
N
-
S
-
V
V
N
P
F
I
Y
A
Y
R
I
R
E
-
F
R
Q
T
F
R
K
I
I
R
-
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.03
22%
-153
- C3 -
3VG9
8
?
A:
[18-301]
---------------------------------------------------------------------------------------------------------
V
L
-
A
I
L
-----------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
-
N
V
--
T
N
Y
F
V
V
S
L
A
-----
A
--
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
-
A
A
---------
C
H
G
C
L
F
I
A
C
FV
L
V
L
T
Q
S
S
I
F
-
S
--------------
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
-----------------
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------
V
L
S
F
A
I
G
-
L
-
T
P
M
L
G
-
W
N
N
------------
C
GQS-------
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
----
V
V
P
M
------
N
Y
M
V
Y
--------
F
--------
N
F
----------------
F
A
C
V
L
V
P
L
L
L
M
--
L
G
V
Y
L
R
----
I
F
L
A
A
-----
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------
P
-----
G
E
--------------------------------------
R
A
R
S
T
--
L
Q
K
E
--------------
V
H
A
A
K
S
L
A
I
I
V
-----
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
------
P
D
C
-------
S
------------
H
---
A
---
P
L
--
W
---
L
M
Y
------
L
A
I
V
L
------
S
H
T
N
-
S
-
V
V
N
P
F
I
Y
A
Y
R
I
R
E
-
F
R
Q
T
F
R
K
I
I
R
-
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.81
22%
-151
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[18-301]
---------------------------------------------------------------------------------------------------------
V
L
-
A
I
L
-----------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
-
N
V
--
T
N
Y
F
V
V
S
L
A
-----
A
--
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
-
A
A
---------
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
-
S
--------------
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
-----------------
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------
V
L
S
F
A
I
G
-
L
-
T
P
M
L
G
-
W
N
N
------------
C
GQS-------
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
----
V
V
P
M
------
N
Y
M
V
Y
--------
F
--------
N
F
----------------
F
A
C
V
L
V
P
L
L
L
M
--
L
G
V
Y
L
R
----
I
F
L
A
A
-----
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------
P
-----
G
E
--------------------------------------
R
A
R
S
T
--
L
Q
K
E
--------------
V
H
A
A
K
S
L
A
I
I
V
-----
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
------
P
D
C
-------
S
------------
H
---
A
---
P
L
--
W
---
L
M
Y
------
L
A
I
V
L
------
S
H
T
N
-
S
-
V
V
N
P
F
I
Y
A
Y
R
I
R
E
-
F
R
Q
T
F
R
K
I
I
R
-
S
H
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
83.55
21%
-146
- C3 -
4UHR
1
AA2AR_HUMAN
A:
[18-301]
---------------------------------------------------------------------------------------------------------
V
L
-
A
I
L
-----------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
-
N
V
--
T
N
Y
F
V
V
S
A
A
-----
A
--
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
-
A
A
---------
C
H
G
C
L
F
I
A
C
----
F
V
L
V
L
T
A
-
S
S
I
F
S
----------
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
-----------------
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------
V
L
S
F
A
I
G
-
L
-
T
P
M
L
G
-
W
N
N
------------
C
GQPKEGKA---
G
C
G
E
G
Q
V
A
C
L
F
E
D
----
V
V
P
M
------
N
Y
M
V
Y
--------
F
--------
N
F
----------------
F
A
C
V
L
V
P
L
L
L
M
--
L
G
V
Y
L
R
----
I
F
L
A
A
-----
R
R
Q
L
K
Q
M
E
S
QP
L
-------
P
-----
G
E
--------------------------------------
R
A
R
S
T
--
L
Q
K
E
--------------
V
H
A
A
K
S
L
A
I
I
V
-----
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
------
P
D
C
--------------------
H
---
A
---
P
L
--
W
---
L
M
Y
------
L
A
I
V
L
------
S
H
T
N
-
S
-
V
V
N
P
F
I
Y
A
Y
R
I
R
E
-
F
R
Q
T
F
R
K
I
I
R
-
S
H
V
L
R
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
80.46
18%
-126
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-----------------
M
N
G
T
E
G
PNFYVPFSNKTG
V
V
-
R
S
P
F
E
A
P
Q
Y
Y
L
-----
A
--------
E
---
P
W
Q
F
S
M
L
----------
A
A
Y
-------
M
F
L
L
-
I
-----
M
L
-
G
F
P
-----------
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
-
T
P
--
L
N
Y
I
L
L
N
L
A
-----
V
--
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
T
S
L
-
H
G
---------
Y
F
V
F
G
P
T
G
C
----
N
L
E
G
F
F
A
-
T
L
G
G
E
I
A
L
W
S
-----
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
----------------------------------
N
F
R
F
---------
G
E
N
H
A
I
M
-
G
-
V
A
F
T
W
-
V
M
A
------------
L
----------
A
C
A
A
P
P
L
V
G
--
W
S
R
----
Y
I
P
E
G-----
M
Q
C
S
C
G
I
DYYTPH
E
--------
E
T
-----
N
N
E
S
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
V
I
--
F
F
C
Y
G
Q
----
L
V
F
T
V
-----
K
E
---------
A
-------
A
AQQQE
S
A
-----------
T
--------------------
T
Q
K
---
A
E
K
E
V
--
T
R
M
V
--------------
I
-------
I
M
V
-----
I
A
F
L
I
C
W
L
-------
P
Y
A
G
-
V
------
A
F
Y
-------
I
------------
F
---
T
---
H
Q
--
G
---
S
D
F
GPIFM
T
I
P
A
F
F
------
A
K
T
S
-
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
-
F
R
N
C
M
V
T
T
L
C
-
C
G
K
N
P
L
GDDEA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
78.71
14%
-156
- C3 -
2Z73
5
OPSD_TODPA
A:
[33-332]
----------------------------------------------------------------------
V
Y
Y
S
----------
L
G
I
-------
F
I
G
I
C
G
-----
I
I
-
G
C
G
-----------
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
-
T
P
--
A
N
M
F
I
I
N
L
A
-----
F
--
S
D
F
T
F
S
L
V
N
G
F
P
---
L
M
T
I
S
C
F
-
L
K
---------
K
W
I
F
G
F
A
A
C
----
K
V
Y
G
F
I
G
-
G
I
F
G
F
M
S
I
M
T
-----
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
-----------------
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
---------
L
W
S
V
L
W
A
-
I
-
G
P
I
F
G
-
W
G
A
------------
Y
----------
T
L
----
E
G
V
L
C
N
C
S
----
F
D
Y
I
------
S
---------------------
R
D
-----
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
--
F
F
C
Y
F
N
----
I
V
M
S
V
-----
S
N
---------
H
-------
E
-----
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
---
R
L
A
K
I
--
S
I
V
I
--------------
V
-------
S
Q
F
-----
L
L
S
W
S
P
Y
A
-------
V
V
A
L
-
L
------
A
Q
F
-------
G
------------
P
LEW
V
---
T
P
--
Y
---
A
A
Q
------
L
P
V
M
F
------
A
K
A
S
-
A
-
I
H
N
P
M
I
Y
S
V
S
H
P
K
-
F
R
E
A
I
S
Q
T
F
P
-
W
V
L
T
C
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
76.28
15%
-150
- C3 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
-------------------------------------------------------------------------
L
----------
W
A
A
-------
A
Y
T
V
I
V
-----
V
T
-
S
V
V
-----------
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
-
T
V
--
T
N
Y
F
L
V
N
L
A
-----
F
--
A
E
A
S
M
A
A
F
N
-
T
V
---
V
N
F
T
Y
A
V
-
H
N
---------
E
W
Y
Y
G
L
F
Y
C
----
K
F
H
N
F
F
P
-
I
A
A
V
F
A
S
I
Y
S
-----
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
-----------------
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
---------
V
L
A
L
L
L
A
-
F
-
P
Q
G
Y
Y
-
S
T
T
-----------------------
E
T
----
M
P
S
R
V
V
C
M
----
I
E
W
P
------
E
H
-----------
P
--------
N
K
-----
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
--
G
Y
A
Y
T
V
----
V
G
I
T
L
-----
W
A
---------
S
-------
E
-----
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
R
---
K
V
V
K
M
--
M
I
V
V
--------------
V
-------
C
T
F
-----
A
I
C
W
L
P
F
H
-------
I
F
F
L
-
L
------
P
Y
I
-------
N
------------
P
---
D
LYL
K
K
--
F
I
Q
Q
V
Y
L
------
A
I
M
W
L
------
A
M
S
S
-
T
-
M
Y
N
P
I
I
Y
C
C
L
N
D
R
-
F
R
L
G
F
K
H
A
F
R
-
C
C
P
F
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
74.16
15%
-135
* C3 *
1U19
14
OPSD_BOVIN
A:
[41-327]
------------------------------------------------------------------------
S
M
----------
L
A
A
-------
Y
M
F
L
L
I
-----
M
L
-
G
F
P
-----------
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
-
T
P
--
L
N
Y
I
L
L
N
L
A
-----
V
--
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
T
S
L
-
H
G
---------
Y
F
V
F
G
P
T
G
C
----
N
L
E
G
F
F
A
-
T
L
G
G
E
I
A
L
W
S
-----
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-----------------
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
---------
V
M
A
L
A
C
A
-
A
-
P
P
L
V
G
-
W
S
R
------------
Y
----------
I
P
----
E
G
M
Q
C
S
C
G
----
I
D
Y
Y
------
T
P
-----------
H
--------
E
E
-----
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
--
F
F
C
Y
G
Q
----
L
V
F
T
V
-----
K
E
---------
A
-------
A
-----
A
Q
-----------
Q
QESA
T
T
Q
K
------------
A
E
K
---
E
V
T
R
M
--
V
I
I
M
--------------
V
-------
I
A
F
-----
L
I
C
W
L
P
Y
A
-------
G
V
A
F
-
Y
------
I
F
T
-------
H
------------
Q
GSD
F
---
G
P
--
I
---
F
M
T
------
I
P
A
F
F
------
A
K
T
S
-
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
-
F
R
N
C
M
V
T
T
L
C
-
C
G
K
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
72.13
14%
-136
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-------------------------------------------------------------------
D
E
V
W
V
V
G
----------
M
G
I
-------
V
M
S
L
I
V
-----
L
A
-
I
V
F
-----------
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
-
T
V
--
T
N
Y
F
I
T
S
L
A
-----
C
--
A
D
L
V
M
G
L
A
V
-
V
P
---
F
G
A
A
H
I
L
-
M
K
---------
M
W
T
F
G
N
F
W
C
----
E
F
W
T
S
I
D
-
V
L
C
V
T
A
S
I
E
T
-----
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
-----------------
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
---------
I
V
S
G
L
T
S
-
F
-
L
P
I
Q
M
------------------------------
H
W
Y
R
A
T
H
Q
E
A
I
----
N
C
Y
A
------
E
E
T
C
C
-----------------
D
F
-----
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
--
V
F
V
Y
S
R
----
V
F
Q
E
A
-----
K
R
Q
--------
L
-------
N
-----
I
F
-----------
E
--------------------
M
L
R
---
I
D
E
G
L
--
R
L
K
I
--------------
Y
-------
K
D
T
-----
E
G
Y
Y
T
I
G
I
-------
G
H
L
L
-
T
------
K
S
P
-------
S
------------
L
---
N
---
A
A
--
K
---
S
E
L
------
D
K
A
I
G
------
R
N
T
N
G
V
-
I
T
K
D
E
A
E
K
L
F
N
Q
D
-
V
D
A
A
V
R
G
I
L
R
-
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
32
HHSearch
66.51
22%
-161
- C3 -
3EML
8
ENLYS_BPT4
A:
[22-222]
------------------------------------------------------------------------
S
V
----------
Y
I
T
-------
V
E
L
A
I
A
-----
V
L
-
A
I
L
-----------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
-
N
V
--
T
N
Y
F
V
V
S
L
A
-----
A
--
A
D
I
A
V
G
V
L
A
-
I
P
---
F
A
I
T
I
S
T
------------
G
F
C
A
A
C
H
G
C
----
L
F
I
A
C
F
V
-
L
V
L
T
Q
S
S
I
F
S
-----
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
-----------------
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------
V
L
S
F
A
I
G
-
L
-
T
P
M
L
G
-
W
N
N
------------
C
----------
G
Q
-------
S
Q
G
C
G
----
E
G
Q
---------
V
A
C
--------
L
--------
F
E
DV---
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
--
L
G
V
Y
L
R
----
I
F
L
A
A
-----
R
R
---------
Q
-------
L
-----
N
I
-----------
F
--------------------
E
M
L
---
R
I
D
E
G
--
L
R
L
K
--------------
I
-------
Y
K
D
-----
T
E
G
Y
Y
T
I
G
-------
I
G
H
L
-
L
------
T
K
S
-------
P
------------
S
---
L
---
N
A
--
A
---
K
S
E
------
L
D
K
A
I
------
G
R
N
T
-
N
-
G
V
I
T
K
D
E
A
E
K
L
F
N
-
Q
D
V
D
A
A
V
R
G
I
-
L
R
N
A
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
65.06
13%
-137
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[36-323]
--------------------------------------------------------------------
T
L
N
K
Y
V
----------
V
I
I
-------
A
Y
A
L
V
F
-----
L
L
-
S
L
L
-----------
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
-
S
V
--
T
D
V
Y
L
L
N
L
A
-----
L
--
A
D
L
L
F
A
L
-
T
-
L
P
---
I
W
A
A
S
K
V
--
N
---------
G
W
I
F
G
T
F
L
C
----
K
V
V
S
L
L
K
-
E
V
N
F
Y
S
G
I
L
L
-----
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
-----------------
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
---------
G
L
S
M
N
L
S
-
L
-
P
F
F
L
F
-
R
Q
A
------------
Y
----------
H
P
----
N
N
S
S
P
V
C
Y
----
E
V
L
G
------
N
------------
D
--------
T
A
-----
K
W
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
--
L
F
C
Y
G
F
----
T
L
R
T
L
-----
F
K
---------
A
-------
H
-----
M
------------
G
--------------------
Q
K
H
---
R
A
M
R
V
--
I
F
A
V
--------------
V
-------
L
I
F
-----
L
L
C
W
L
P
Y
N
-------
L
V
L
L
-
A
------
D
T
L
-------
M
RTQVIQE-----
S
C
E
R
R
---
N
N
I
G
R
---
A
L
D
------
A
T
E
I
L
------
G
F
L
H
-
S
-
C
L
N
P
I
I
Y
A
F
I
G
Q
N
-
F
R
H
G
F
L
K
I
L
A
-
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
63.46
17%
-149
- C3 -
2RH1
6
ADRB2_HUMAN (first)
A:
[41-236]
------------------------------------------------------------------------
V
G
----------
M
G
I
-------
V
M
S
L
I
V
-----
L
A
-
I
V
F
-----------
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
-
T
V
--
T
N
Y
F
I
T
S
L
A
-----
C
--
A
D
L
V
M
G
L
A
V
-
V
P
---
F
G
A
A
H
I
L
-
M
K
---------
M
W
T
F
G
N
F
W
C
----
E
F
W
T
S
I
D
-
V
L
C
V
T
A
S
I
E
T
-----
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
-----------------
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
---------
I
V
S
G
L
T
S
-
F
-
L
P
I
Q
M
H
W
Y
R
------------
A
----------
T
H
Q
-----
E
A
I
N
C
Y
----
A
E
E
----------
T
C
--------
C
--------
D
F
-----
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
--
V
F
V
Y
S
R
----
V
F
Q
E
A
-----
K
R
---------
Q
-------
L
-----
N
I
-----------
F
--------------------
E
M
L
---
R
I
D
E
G
--
L
R
L
K
--------------
I
-------
Y
K
D
-----
T
E
G
Y
Y
T
I
G
-------
I
G
H
L
-
L
------
T
K
S
-------
P
------------
S
---
L
---
N
A
--
A
---
K
S
E
------
L
D
K
A
I
------
G
R
N
T
-
N
-
G
V
I
T
K
D
E
A
E
K
L
F
N
-
Q
D
V
D
A
A
V
R
G
I
-
L
R
N
A
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
61.13
17%
-163
- C1 -
4XR7
-
PAN3_YEAST
B:
[1-456]
MH
S
L
L
Q
YRSADQLFIPN
N
I
R
E
--------------
D
L
-
T
K
K
N
L
S
I
L
Q
V
F
-----
P
SSGKVIPS
I
---
V
Q
D
Y
F
N
L
----------
V
P
L
NFNNKT
T
L
F
K
V
F
S
NYDGK
A
Y
-
V
L
K
R
LPNIDKSMNP
N
K
I
S
K
I
Y
Q
I
W
S
K
I
N
C
T
-
N
L
I
K
F
R
D
I
F
Q
T
T
K
-----
F
G
D
L
S
I
C
L
V
F
D
Y
-
Y
P
---
N
S
L
S
L
Y
D
-
Y
H
FVNFPKFPI
T
N
N
Y
L
W
I
Y
L
----
V
Q
L
T
N
V
I
-
N
S
I
H
S
Q
N
L
S
I
-----
G
N
T
L
N
W
R
K
V
L
I
T
G
D
P
G
R
I
K
L
S
HCNF
M
D
L
L
F
N
DDTDT
V
V
---
S
S
T
I
E
G
Q
Q
Q
L
D
Y
K
Y
---------
L
G
E
L
L
F
N
-
L
-
S
I
N
I
E
-
N
S
N
NN
T
A
P
K
E
Y
R
LEE
I
----------
T
P
Q
S
I
D
D
M
R
Q
I
D
D
K
----
F
K
D
V
------
L
K
Y
L
I
--------
S
--------
D
N
G
DSKK
S
I
H
D
L
T
S
H
F
Y
D
K
M
F
M
V
L
E
S
S
Q
T
--
Y
T
E
Y
M
E
----
S
V
L
S
R
E
LE
N
G
R
L
---------
F
-------
R
-----
L
V
-----------
N
--------------------
K
L
N
---
C
I
F
G
R
--
I
E
S
R
--------------
I
-------
D
I
N
WSESG
T
K
F
P
I
I
L
F
-------
Y
D
Y
V
-
F
------
H
Q
V
D
S
N
G
K
P
I
M
------------
D
---
L
---
T
H
--
V
---
L
R
C
------
L
N
K
L
D
A
GIQ
E
K
L
M
L
V
-
T
-
P
D
E
L
N
C
I
I
I
S
Y
K
E
-
L
K
D
L
I
E
S
T
F
--
R
S
I
T
Q
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
58.93
18%
-153
- C3 -
3UON
2
ACM2_HUMAN (first)
A:
[24-215]
------------------------------------------------------------------------
V
F
----------
I
V
L
-------
V
A
G
S
L
S
-----
L
V
-
T
I
I
-----------
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
-
T
V
--
N
N
Y
F
L
F
S
L
A
-----
C
--
A
D
L
I
I
G
V
F
S
-
M
N
---
L
Y
T
L
Y
T
V
-
I
G
---------
Y
W
P
L
G
P
V
V
C
----
D
L
W
L
A
L
D
-
Y
V
V
S
N
A
S
V
M
N
-----
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
-----------------
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
---------
V
L
S
F
I
L
W
-
A
-
P
A
I
L
F
-
W
Q
F
------------
I
----------
V
G
V
R
--
T
V
E
D
G
E
C
Y
----
I
Q
F
F
------------------------------------
S
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
--
T
V
L
Y
W
H
----
I
S
R
A
S
-----
K
S
---------
R
-------
I
-----
N
I
-----------
F
--------------------
E
M
L
---
R
I
D
E
G
--
L
R
L
K
--------------
I
-------
Y
K
D
-----
T
E
G
Y
Y
T
I
G
-------
I
G
H
L
-
L
------
T
K
S
-------
P
------------
S
---
L
---
N
A
--
A
---
K
S
E
------
L
D
K
A
I
------
G
R
N
T
-
N
-
G
V
I
T
K
D
E
A
E
K
L
F
N
-
Q
D
V
D
A
A
V
R
G
I
-
L
R
N
A
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
58.74
18%
-144
- C3 -
3RZE
2
ENLYS_BPT4 (first)
A:
[9-201]
------------------------------------------------------------------------
M
P
----------
L
V
V
-------
V
L
S
T
I
C
-----
L
V
-
T
V
G
-----------
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
-
T
V
--
G
N
L
Y
I
V
S
L
S
-----
V
--
A
D
L
I
V
G
A
V
V
-
M
P
---
M
N
I
L
Y
L
L
-
M
S
---------
K
W
S
L
G
R
P
L
C
----
L
F
W
L
S
M
D
-
Y
V
A
S
T
A
S
I
F
S
-----
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
-----------------
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
---------
F
L
S
F
L
W
V
-
I
-
P
I
L
-
G
-
W
N
H
------------------------------
R
R
E
D
K
C
E
----
T
D
F
Y
----------------------------
D
--------
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
--
L
W
F
Y
A
K
----
I
Y
K
A
V
-----
R
Q
---------
H
-------
C
-----
N
I
-----------
F
--------------------
E
M
L
---
R
I
D
E
G
--
L
R
L
K
--------------
I
-------
Y
K
D
-----
T
E
G
Y
Y
T
I
G
-------
I
G
H
L
-
L
------
T
K
S
-------
P
------------
S
---
L
---
N
A
--
A
---
K
S
E
------
L
D
K
A
I
------
G
R
N
T
-
N
-
G
V
I
T
K
D
E
A
E
K
L
F
N
-
Q
D
V
D
A
A
V
R
G
I
-
L
R
N
A
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
58.03
15%
-178
- C2 -
4QT9
2
?
A:
[19-432]
-----------------
L
S
D
D
--------------
A
L
M
D
T
V
Q
R
R
T
F
L
Y
F
W
EGAE
P
--------
N
SGL
A
P
E
R
Y
H
V
DGVYPQNDAN
V
V
T
-------
S
G
G
S
G
F
-----
G
I
M
A
I
L
-----------
A
G
I
D
R
G
Y
V
T
R
E
E
G
L
A
R
M
E
R
--
I
V
S
F
L
E
K
A
D
RFHGA
Y
--
P
H
W
W
Y
G
D
T
-----------
G
K
V
-
K
P
---------
F
G
Q
K
D
N
G
G
D
----
L
V
E
T
A
F
L
M
Q
G
L
L
A
V
H
Q
Y
Y
A
NGN
D
K
E
K
A
I
A
Q
R
I
D
R
L
W
R
E
V
D
W
D
-----------------
W
Y
---
R
K
G
G
Q
N
V
L
Y
W
H
W
S
P
TYGWEMD
F
P
I
H
G
Y
N
E
C
M
I
M
Y
I
L
A
A
-
A
S
P
------------
T
----------
H
G
V
P
A
A
V
Y
H
D
G
W
A
Q
NGAI
V
S
P
H
K
V
EGIE
L
H
L
R
Y
--------
Q
--------
G
T
-----
E
A
G
P
L
F
W
A
Q
Y
S
F
L
G
L
D
P
V
G
L
K
D
EY
C
P
S
Y
F
H
E
M
R
N
L
T
L
V
N
-----
R
A
---------
Y
-------
C
-----
I
R
-----------
N
PKHYKGFGP-----------
D
C
W
G
L
T
A
S
Y
S
V
DG
Y
A
A
H
SPNEQDDKGVISPT
A
-------
A
L
S
-----
S
I
V
Y
T
P
E
Y
-------
S
L
Q
V
M
R
H
L
Y
N
M
G
D
K
V
-------
F
GPFGFYDAFSET
D
---
N
---
W
Y
--
P
---
Q
R
Y
------
L
A
I
D
Q
------
G
P
I
A
-
V
M
I
E
N
Y
R
T
G
L
L
W
K
L
F
M
S
H
P
D
V
Q
A
G
L
T
K
L
G
F
N
T
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
55.12
15%
-150
- C3 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-226]
------------------------------------------------------------------------------------
Y
A
L
-------
S
Y
C
A
L
I
-----
L
A
-
I
V
F
-----------
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
-
T
T
--
T
N
Y
L
V
V
S
L
A
-----
V
--
A
D
L
L
V
A
T
L
V
-
M
P
---
W
V
V
Y
L
E
V
T
G
G
---------
V
W
N
F
S
R
I
C
C
----
D
V
F
V
T
L
D
-
V
M
M
C
T
A
S
I
W
N
-----
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
-----------------
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
---------
V
L
A
F
A
V
S
-
C
-
P
L
L
F
G
-
F
N
T
------------
T
-----------------
G
D
P
T
V
C
S
----
I
S
N
-------------------------------------
P
--
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
--
V
L
V
Y
A
R
----
I
Y
V
V
L
-----
K
Q
---------
R
-------
R
-----
R
K
-----------
N
--------------------
I
F
E
---
M
L
R
I
D
--
E
G
L
R
--------------
L
-------
K
I
Y
-----
K
D
T
E
G
Y
Y
T
-------
I
G
I
G
-
H
------
L
L
T
-------
K
------------
S
---
P
---
S
L
--
N
---
A
A
K
------
S
E
L
D
K
------
A
I
G
R
-
N
-
T
N
G
V
I
T
K
D
E
A
E
K
L
-
F
N
Q
D
V
D
A
A
V
R
-
G
I
L
R
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------